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Entry version 136 (29 Sep 2021)
Sequence version 2 (26 Feb 2008)
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Protein

TBC1 domain family member 30

Gene

TBC1D30

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

GTPase-activating protein (GAP) with broad specificity. Acts as a GAP for RAB3A. Also exhibits significant GAP activity toward RAB22A, RAB27A, and RAB35 in vitro.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...
PathwayCommonsi
Q9Y2I9

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
TBC1 domain family member 30
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:TBC1D30
Synonyms:KIAA0984
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 12

Organism-specific databases

Human Gene Nomenclature Database

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HGNCi
HGNC:29164, TBC1D30

Online Mendelian Inheritance in Man (OMIM)

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MIMi
615077, gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q9Y2I9

Eukaryotic Pathogen, Vector and Host Database Resources

More...
VEuPathDBi
HostDB:ENSG00000111490

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Cell membrane, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi303R → K: Loss of GAP activity. 1 Publication1

Organism-specific databases

DisGeNET

More...
DisGeNETi
23329

Open Targets

More...
OpenTargetsi
ENSG00000111490

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA162405327

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q9Y2I9, Tbio

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
TBC1D30

Domain mapping of disease mutations (DMDM)

More...
DMDMi
172046608

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003206521 – 924TBC1 domain family member 30Add BLAST924

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei800PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q9Y2I9

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q9Y2I9

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
Q9Y2I9

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q9Y2I9

PeptideAtlas

More...
PeptideAtlasi
Q9Y2I9

PRoteomics IDEntifications database

More...
PRIDEi
Q9Y2I9

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
85806 [Q9Y2I9-1]
85807 [Q9Y2I9-2]
85808 [Q9Y2I9-3]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q9Y2I9

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q9Y2I9

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000111490, Expressed in neocortex and 190 other tissues

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
Q9Y2I9, baseline and differential

Organism-specific databases

Human Protein Atlas

More...
HPAi
ENSG00000111490, Tissue enhanced (pancreas)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

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BioGRIDi
116917, 20 interactors

Protein interaction database and analysis system

More...
IntActi
Q9Y2I9, 12 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000440207

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q9Y2I9, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini249 – 457Rab-GAP TBCPROSITE-ProRule annotationAdd BLAST209

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 76DisorderedSequence analysisAdd BLAST76
Regioni94 – 134DisorderedSequence analysisAdd BLAST41
Regioni541 – 564DisorderedSequence analysisAdd BLAST24
Regioni776 – 806DisorderedSequence analysisAdd BLAST31
Regioni838 – 924DisorderedSequence analysisAdd BLAST87

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi47 – 61Basic and acidic residuesSequence analysisAdd BLAST15
Compositional biasi99 – 118Basic and acidic residuesSequence analysisAdd BLAST20
Compositional biasi780 – 798Polar residuesSequence analysisAdd BLAST19
Compositional biasi856 – 873Polar residuesSequence analysisAdd BLAST18
Compositional biasi901 – 924Polar residuesSequence analysisAdd BLAST24

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
KOG2058, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000159226

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q9Y2I9

Identification of Orthologs from Complete Genome Data

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OMAi
KSHLGCG

Database of Orthologous Groups

More...
OrthoDBi
1162786at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q9Y2I9

TreeFam database of animal gene trees

More...
TreeFami
TF321898

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR000195, Rab-GTPase-TBC_dom
IPR035969, Rab-GTPase_TBC_sf
IPR032738, Tbc1d30_C

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF15733, DUF4682, 1 hit
PF00566, RabGAP-TBC, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00164, TBC, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF47923, SSF47923, 2 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50086, TBC_RABGAP, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 3 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 4 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q9Y2I9-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MDVLPTGGGR PGLRTELEFR GGGGEARLES QEEETIPAAP PAPRLRGAAE
60 70 80 90 100
RPRRSRDTWD GDEDTEPGEA CGGRTSRTAS LVSGLLNELY SCTEEEEAAG
110 120 130 140 150
GGRGAEGRRR RRDSLDSSTE ASGSDVVLGG RSGAGDSRVL QELQERPSQR
160 170 180 190 200
HQMLYLRQKD ANELKTILRE LKYRIGIQSA KLLRHLKQKD RLLHKVQRNC
210 220 230 240 250
DIVTACLQAV SQKRRVDTKL KFTLEPSLGQ NGFQQWYDAL KAVARLSTGI
260 270 280 290 300
PKEWRRKVWL TLADHYLHSI AIDWDKTMRF TFNERSNPDD DSMGIQIVKD
310 320 330 340 350
LHRTGCSSYC GQEAEQDRVV LKRVLLAYAR WNKTVGYCQG FNILAALILE
360 370 380 390 400
VMEGNEGDAL KIMIYLIDKV LPESYFVNNL RALSVDMAVF RDLLRMKLPE
410 420 430 440 450
LSQHLDTLQR TANKESGGGY EPPLTNVFTM QWFLTLFATC LPNQTVLKIW
460 470 480 490 500
DSVFFEGSEI ILRVSLAIWA KLGEQIECCE TADEFYSTMG RLTQEMLEND
510 520 530 540 550
LLQSHELMQT VYSMAPFPFP QLAELREKYT YNITPFPATV KPTSVSGRHS
560 570 580 590 600
KARDSDEEND PDDEDAVVNA VGCLGPFSGF LAPELQKYQK QIKEPNEEQS
610 620 630 640 650
LRSNNIAELS PGAINSCRSE YHAAFNSMMM ERMTTDINAL KRQYSRIKKK
660 670 680 690 700
QQQQVHQVYI RADKGPVTSI LPSQVNSSPV INHLLLGKKM KMTNRAAKNA
710 720 730 740 750
VIHIPGHTGG KISPVPYEDL KTKLNSPWRT HIRVHKKNMP RTKSHPGCGD
760 770 780 790 800
TVGLIDEQNE ASKTNGLGAA EAFPSGCTAT AGREGSSPEG STRRTIEGQS
810 820 830 840 850
PEPVFGDADV DVSAVQAKLG ALELNQRDAA AETELRVHPP CQRHCPEPPS
860 870 880 890 900
APEENKATSK APQGSNSKTP IFSPFPSVKP LRKSATARNL GLYGPTERTP
910 920
TVHFPQMSRS FSKPGGGNSG TKKR
Length:924
Mass (Da):102,743
Last modified:February 26, 2008 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i36C626CD533F58A7
GO
Isoform 2 (identifier: Q9Y2I9-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-215: MDVLPTGGGR...CLQAVSQKRR → MRQDKLTGSL...PRLLCTLEPG

Show »
Length:761
Mass (Da):84,683
Checksum:i6663AC4CA89BB110
GO
Isoform 3 (identifier: Q9Y2I9-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-215: MDVLPTGGGR...CLQAVSQKRR → MRQDKLTGSL...PRLLCTLEPG
     792-924: TRRTIEGQSP...GGGNSGTKKR → SSYKSLQMI

Show »
Length:637
Mass (Da):71,466
Checksum:iFE8ABEF2D3FD36F8
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
F8VZ81F8VZ81_HUMAN
TBC1 domain family member 30
TBC1D30
647Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F5H7L7F5H7L7_HUMAN
TBC1 domain family member 30
TBC1D30
91Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F5H0E8F5H0E8_HUMAN
TBC1 domain family member 30
TBC1D30
123Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A6I8PRH3A0A6I8PRH3_HUMAN
TBC1 domain family member 30
TBC1D30
21Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence BAA76828 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti770A → S in BAG51513 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_039261296Q → H. Corresponds to variant dbSNP:rs11615287Ensembl.1
Natural variantiVAR_052544596N → D. Corresponds to variant dbSNP:rs2290527Ensembl.1
Natural variantiVAR_039262752V → I1 PublicationCorresponds to variant dbSNP:rs939875Ensembl.1
Natural variantiVAR_059857759N → D. Corresponds to variant dbSNP:rs2290527Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0424271 – 215MDVLP…SQKRR → MRQDKLTGSLRRGGRCLKRQ GGGVGTILSNVLKKRSCISR TAPRLLCTLEPG in isoform 2 and isoform 3. 2 PublicationsAdd BLAST215
Alternative sequenceiVSP_042428792 – 924TRRTI…GTKKR → SSYKSLQMI in isoform 3. 1 PublicationAdd BLAST133

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AB449914 mRNA Translation: BAH16657.1
AK055404 mRNA Translation: BAG51513.1
AC025262 Genomic DNA No translation available.
AC078815 Genomic DNA No translation available.
AB023201 mRNA Translation: BAA76828.1 Different initiation.

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS53813.1 [Q9Y2I9-2]

NCBI Reference Sequences

More...
RefSeqi
NP_001317115.1, NM_001330186.1
NP_001317116.1, NM_001330187.1
NP_001317117.1, NM_001330188.1
NP_056094.1, NM_015279.1 [Q9Y2I9-2]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000539867; ENSP00000440207; ENSG00000111490 [Q9Y2I9-2]
ENST00000542120; ENSP00000440640; ENSG00000111490 [Q9Y2I9-1]

Database of genes from NCBI RefSeq genomes

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GeneIDi
23329

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:23329

UCSC genome browser

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UCSCi
uc010sst.3, human [Q9Y2I9-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB449914 mRNA Translation: BAH16657.1
AK055404 mRNA Translation: BAG51513.1
AC025262 Genomic DNA No translation available.
AC078815 Genomic DNA No translation available.
AB023201 mRNA Translation: BAA76828.1 Different initiation.
CCDSiCCDS53813.1 [Q9Y2I9-2]
RefSeqiNP_001317115.1, NM_001330186.1
NP_001317116.1, NM_001330187.1
NP_001317117.1, NM_001330188.1
NP_056094.1, NM_015279.1 [Q9Y2I9-2]

3D structure databases

Database of comparative protein structure models

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ModBasei
Search...

SWISS-MODEL Interactive Workspace

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SWISS-MODEL-Workspacei
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Protein-protein interaction databases

BioGRIDi116917, 20 interactors
IntActiQ9Y2I9, 12 interactors
STRINGi9606.ENSP00000440207

PTM databases

iPTMnetiQ9Y2I9
PhosphoSitePlusiQ9Y2I9

Genetic variation databases

BioMutaiTBC1D30
DMDMi172046608

Proteomic databases

EPDiQ9Y2I9
jPOSTiQ9Y2I9
MassIVEiQ9Y2I9
PaxDbiQ9Y2I9
PeptideAtlasiQ9Y2I9
PRIDEiQ9Y2I9
ProteomicsDBi85806 [Q9Y2I9-1]
85807 [Q9Y2I9-2]
85808 [Q9Y2I9-3]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

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Antibodypediai
51838, 14 antibodies

The DNASU plasmid repository

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DNASUi
23329

Genome annotation databases

EnsembliENST00000539867; ENSP00000440207; ENSG00000111490 [Q9Y2I9-2]
ENST00000542120; ENSP00000440640; ENSG00000111490 [Q9Y2I9-1]
GeneIDi23329
KEGGihsa:23329
UCSCiuc010sst.3, human [Q9Y2I9-1]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
23329
DisGeNETi23329

GeneCards: human genes, protein and diseases

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GeneCardsi
TBC1D30
HGNCiHGNC:29164, TBC1D30
HPAiENSG00000111490, Tissue enhanced (pancreas)
MIMi615077, gene
neXtProtiNX_Q9Y2I9
OpenTargetsiENSG00000111490
PharmGKBiPA162405327
VEuPathDBiHostDB:ENSG00000111490

Human Unidentified Gene-Encoded large proteins database

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HUGEi
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GenAtlas: human gene database

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GenAtlasi
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Phylogenomic databases

eggNOGiKOG2058, Eukaryota
GeneTreeiENSGT00940000159226
InParanoidiQ9Y2I9
OMAiKSHLGCG
OrthoDBi1162786at2759
PhylomeDBiQ9Y2I9
TreeFamiTF321898

Enzyme and pathway databases

PathwayCommonsiQ9Y2I9

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

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BioGRID-ORCSi
23329, 4 hits in 1008 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
TBC1D30, human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
23329
PharosiQ9Y2I9, Tbio

Protein Ontology

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PROi
PR:Q9Y2I9
RNActiQ9Y2I9, protein

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
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Gene expression databases

BgeeiENSG00000111490, Expressed in neocortex and 190 other tissues
ExpressionAtlasiQ9Y2I9, baseline and differential

Family and domain databases

InterProiView protein in InterPro
IPR000195, Rab-GTPase-TBC_dom
IPR035969, Rab-GTPase_TBC_sf
IPR032738, Tbc1d30_C
PfamiView protein in Pfam
PF15733, DUF4682, 1 hit
PF00566, RabGAP-TBC, 1 hit
SMARTiView protein in SMART
SM00164, TBC, 1 hit
SUPFAMiSSF47923, SSF47923, 2 hits
PROSITEiView protein in PROSITE
PS50086, TBC_RABGAP, 1 hit

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiTBC30_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9Y2I9
Secondary accession number(s): B3KP01
, B9A6M9, E7EMW4, F5GYJ9
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 26, 2008
Last sequence update: February 26, 2008
Last modified: September 29, 2021
This is version 136 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
  2. Human entries with genetic variants
    List of human entries with genetic variants
  3. Human variants curated from literature reports
    Index of human variants curated from literature reports
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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