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Protein

WD repeat-containing protein 37

Gene

WDR37

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Enzyme and pathway databases

SignaLinkiQ9Y2I8

Names & Taxonomyi

Protein namesi
Recommended name:
WD repeat-containing protein 37
Gene namesi
Name:WDR37
Synonyms:KIAA0982
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 10

Organism-specific databases

EuPathDBiHostDB:ENSG00000047056.14
HGNCiHGNC:31406 WDR37
neXtProtiNX_Q9Y2I8

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Pathology & Biotechi

Organism-specific databases

DisGeNETi22884
OpenTargetsiENSG00000047056
PharmGKBiPA134922218

Polymorphism and mutation databases

BioMutaiWDR37
DMDMi90122397

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000513871 – 494WD repeat-containing protein 37Add BLAST494

Proteomic databases

EPDiQ9Y2I8
PaxDbiQ9Y2I8
PeptideAtlasiQ9Y2I8
PRIDEiQ9Y2I8
ProteomicsDBi85805

PTM databases

iPTMnetiQ9Y2I8
PhosphoSitePlusiQ9Y2I8
SwissPalmiQ9Y2I8

Expressioni

Gene expression databases

BgeeiENSG00000047056 Expressed in 215 organ(s), highest expression level in amniotic fluid
CleanExiHS_WDR37
ExpressionAtlasiQ9Y2I8 baseline and differential
GenevisibleiQ9Y2I8 HS

Organism-specific databases

HPAiHPA037376
HPA037565

Interactioni

Protein-protein interaction databases

BioGridi116551, 24 interactors
IntActiQ9Y2I8, 3 interactors
MINTiQ9Y2I8
STRINGi9606.ENSP00000263150

Structurei

3D structure databases

ProteinModelPortaliQ9Y2I8
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati154 – 194WD 1Add BLAST41
Repeati197 – 236WD 2Add BLAST40
Repeati279 – 318WD 3Add BLAST40
Repeati321 – 360WD 4Add BLAST40
Repeati365 – 403WD 5Add BLAST39
Repeati406 – 445WD 6Add BLAST40
Repeati452 – 493WD 7Add BLAST42

Keywords - Domaini

Repeat, WD repeat

Phylogenomic databases

eggNOGiKOG0300 Eukaryota
ENOG410XSES LUCA
GeneTreeiENSGT00930000150950
HOGENOMiHOG000013185
HOVERGENiHBG057072
InParanoidiQ9Y2I8
OMAiWDFREAI
OrthoDBiEOG091G06KJ
PhylomeDBiQ9Y2I8
TreeFamiTF105876

Family and domain databases

Gene3Di2.130.10.10, 2 hits
InterProiView protein in InterPro
IPR020472 G-protein_beta_WD-40_rep
IPR015943 WD40/YVTN_repeat-like_dom_sf
IPR001680 WD40_repeat
IPR019775 WD40_repeat_CS
IPR017986 WD40_repeat_dom
IPR036322 WD40_repeat_dom_sf
PfamiView protein in Pfam
PF00400 WD40, 4 hits
PRINTSiPR00320 GPROTEINBRPT
SMARTiView protein in SMART
SM00320 WD40, 6 hits
SUPFAMiSSF50978 SSF50978, 1 hit
PROSITEiView protein in PROSITE
PS00678 WD_REPEATS_1, 2 hits
PS50082 WD_REPEATS_2, 5 hits
PS50294 WD_REPEATS_REGION, 1 hit

Sequences (3+)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 3 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q9Y2I8-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MPTESASCST ARQTKQKRKS HSLSIRRTNS SEQERTGLPR DMLEGQDSKL
60 70 80 90 100
PSSVRSTLLE LFGQIEREFE NLYIENLELR REIDTLNERL AAEGQAIDGA
110 120 130 140 150
ELSKGQLKTK ASHSTSQLSQ KLKTTYKAST SKIVSSFKTT TSRAACQLVK
160 170 180 190 200
EYIGHRDGIW DVSVAKTQPV VLGTASADHT ALLWSIETGK CLVKYAGHVG
210 220 230 240 250
SVNSIKFHPS EQLALTASGD QTAHIWRYAV QLPTPQPVAD TSISGEDEVE
260 270 280 290 300
CSDKDEPDLD GDVSSDCPTI RVPLTSLKSH QGVVIASDWL VGGKQAVTAS
310 320 330 340 350
WDRTANLYDV ETSELVHSLT GHDQELTHCC THPTQRLVVT SSRDTTFRLW
360 370 380 390 400
DFRDPSIHSV NVFQGHTDTV TSAVFTVGDN VVSGSDDRTV KVWDLKNMRS
410 420 430 440 450
PIATIRTDSA INRINVCVGQ KIIALPHDNR QVRLFDMSGV RLARLPRSSR
460 470 480 490
QGHRRMVCCS AWSEDHPVCN LFTCGFDRQA IGWNINIPAL LQEK
Length:494
Mass (Da):54,665
Last modified:March 7, 2006 - v2
Checksum:i49D05A24DD230005
GO
Isoform 2 (identifier: Q9Y2I8-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     242-242: S → SQ

Note: No experimental confirmation available.
Show »
Length:495
Mass (Da):54,794
Checksum:i83408AD0846E3C7A
GO
Isoform 3 (identifier: Q9Y2I8-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     243-264: ISGEDEVECSDKDEPDLDGDVS → VSTFPYLRMCRMLMSANLRIHL
     265-494: Missing.

Note: No experimental confirmation available.
Show »
Length:264
Mass (Da):29,265
Checksum:i3193048FA2098A50
GO

Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
C9JGR9C9JGR9_HUMAN
WD repeat-containing protein 37
WDR37
209Annotation score:
E7EQ49E7EQ49_HUMAN
WD repeat-containing protein 37
WDR37
249Annotation score:
A0A087WTQ2A0A087WTQ2_HUMAN
WD repeat-containing protein 37
WDR37
263Annotation score:

Sequence cautioni

The sequence BAA76826 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti267C → S in BAA76826 (PubMed:10231032).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_07080511A → T1 PublicationCorresponds to variant dbSNP:rs17856557Ensembl.1
Natural variantiVAR_070806221Q → K1 PublicationCorresponds to variant dbSNP:rs17856556Ensembl.1
Natural variantiVAR_025432225I → V. Corresponds to variant dbSNP:rs2306407Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_054011242S → SQ in isoform 2. 1 Publication1
Alternative sequenceiVSP_054012243 – 264ISGED…DGDVS → VSTFPYLRMCRMLMSANLRI HL in isoform 3. 1 PublicationAdd BLAST22
Alternative sequenceiVSP_054013265 – 494Missing in isoform 3. 1 PublicationAdd BLAST230

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB023199 mRNA Translation: BAA76826.2 Different initiation.
AL136827 mRNA Translation: CAB66761.1
AK292591 mRNA Translation: BAF85280.1
AC022536 Genomic DNA No translation available.
AL607085 Genomic DNA No translation available.
CH471072 Genomic DNA Translation: EAW86514.1
CH471072 Genomic DNA Translation: EAW86516.1
BC018044 mRNA Translation: AAH18044.1
CCDSiCCDS7057.1 [Q9Y2I8-1]
PIRiT46442
RefSeqiNP_054742.2, NM_014023.3 [Q9Y2I8-1]
UniGeneiHs.188495

Genome annotation databases

EnsembliENST00000263150; ENSP00000263150; ENSG00000047056 [Q9Y2I8-1]
ENST00000358220; ENSP00000350954; ENSG00000047056 [Q9Y2I8-1]
GeneIDi22884
KEGGihsa:22884
UCSCiuc001igf.2 human [Q9Y2I8-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB023199 mRNA Translation: BAA76826.2 Different initiation.
AL136827 mRNA Translation: CAB66761.1
AK292591 mRNA Translation: BAF85280.1
AC022536 Genomic DNA No translation available.
AL607085 Genomic DNA No translation available.
CH471072 Genomic DNA Translation: EAW86514.1
CH471072 Genomic DNA Translation: EAW86516.1
BC018044 mRNA Translation: AAH18044.1
CCDSiCCDS7057.1 [Q9Y2I8-1]
PIRiT46442
RefSeqiNP_054742.2, NM_014023.3 [Q9Y2I8-1]
UniGeneiHs.188495

3D structure databases

ProteinModelPortaliQ9Y2I8
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi116551, 24 interactors
IntActiQ9Y2I8, 3 interactors
MINTiQ9Y2I8
STRINGi9606.ENSP00000263150

PTM databases

iPTMnetiQ9Y2I8
PhosphoSitePlusiQ9Y2I8
SwissPalmiQ9Y2I8

Polymorphism and mutation databases

BioMutaiWDR37
DMDMi90122397

Proteomic databases

EPDiQ9Y2I8
PaxDbiQ9Y2I8
PeptideAtlasiQ9Y2I8
PRIDEiQ9Y2I8
ProteomicsDBi85805

Protocols and materials databases

DNASUi22884
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000263150; ENSP00000263150; ENSG00000047056 [Q9Y2I8-1]
ENST00000358220; ENSP00000350954; ENSG00000047056 [Q9Y2I8-1]
GeneIDi22884
KEGGihsa:22884
UCSCiuc001igf.2 human [Q9Y2I8-1]

Organism-specific databases

CTDi22884
DisGeNETi22884
EuPathDBiHostDB:ENSG00000047056.14
GeneCardsiWDR37
H-InvDBiHIX0190517
HGNCiHGNC:31406 WDR37
HPAiHPA037376
HPA037565
neXtProtiNX_Q9Y2I8
OpenTargetsiENSG00000047056
PharmGKBiPA134922218
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0300 Eukaryota
ENOG410XSES LUCA
GeneTreeiENSGT00930000150950
HOGENOMiHOG000013185
HOVERGENiHBG057072
InParanoidiQ9Y2I8
OMAiWDFREAI
OrthoDBiEOG091G06KJ
PhylomeDBiQ9Y2I8
TreeFamiTF105876

Enzyme and pathway databases

SignaLinkiQ9Y2I8

Miscellaneous databases

ChiTaRSiWDR37 human
GeneWikiiWDR37
GenomeRNAii22884
PROiPR:Q9Y2I8

Gene expression databases

BgeeiENSG00000047056 Expressed in 215 organ(s), highest expression level in amniotic fluid
CleanExiHS_WDR37
ExpressionAtlasiQ9Y2I8 baseline and differential
GenevisibleiQ9Y2I8 HS

Family and domain databases

Gene3Di2.130.10.10, 2 hits
InterProiView protein in InterPro
IPR020472 G-protein_beta_WD-40_rep
IPR015943 WD40/YVTN_repeat-like_dom_sf
IPR001680 WD40_repeat
IPR019775 WD40_repeat_CS
IPR017986 WD40_repeat_dom
IPR036322 WD40_repeat_dom_sf
PfamiView protein in Pfam
PF00400 WD40, 4 hits
PRINTSiPR00320 GPROTEINBRPT
SMARTiView protein in SMART
SM00320 WD40, 6 hits
SUPFAMiSSF50978 SSF50978, 1 hit
PROSITEiView protein in PROSITE
PS00678 WD_REPEATS_1, 2 hits
PS50082 WD_REPEATS_2, 5 hits
PS50294 WD_REPEATS_REGION, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiWDR37_HUMAN
AccessioniPrimary (citable) accession number: Q9Y2I8
Secondary accession number(s): A8K976
, D3DRQ7, Q5SW03, Q8WVG2, Q9NTJ6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 20, 2001
Last sequence update: March 7, 2006
Last modified: November 7, 2018
This is version 154 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  2. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  3. Human chromosome 10
    Human chromosome 10: entries, gene names and cross-references to MIM
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