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Protein

1-phosphatidylinositol 3-phosphate 5-kinase

Gene

PIKFYVE

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

The PI(3,5)P2 regulatory complex regulates both the synthesis and turnover of phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2). Catalyzes the phosphorylation of phosphatidylinositol 3-phosphate on the fifth hydroxyl of the myo-inositol ring, to form phosphatidylinositol 3,5-bisphosphate. Required for endocytic-vacuolar pathway and nuclear migration. Plays a role in the biogenesis of endosome carrier vesicles (ECV)/ multivesicular bodies (MVB) transport intermediates from early endosomes.1 Publication

Catalytic activityi

ATP + 1-phosphatidyl-1D-myo-inositol 3-phosphate = ADP + 1-phosphatidyl-1D-myo-inositol 3,5-bisphosphate.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri158 – 218FYVE-typePROSITE-ProRule annotationAdd BLAST61

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionKinase, Transferase
LigandATP-binding, Metal-binding, Nucleotide-binding, Zinc

Enzyme and pathway databases

BioCyciMetaCyc:HS03825-MONOMER
BRENDAi2.7.1.150 2681
2.7.1.68 2681
ReactomeiR-HSA-1660514 Synthesis of PIPs at the Golgi membrane
R-HSA-1660516 Synthesis of PIPs at the early endosome membrane
R-HSA-1660517 Synthesis of PIPs at the late endosome membrane
SIGNORiQ9Y2I7

Names & Taxonomyi

Protein namesi
Recommended name:
1-phosphatidylinositol 3-phosphate 5-kinase (EC:2.7.1.150)
Short name:
Phosphatidylinositol 3-phosphate 5-kinase
Alternative name(s):
FYVE finger-containing phosphoinositide kinase
PIKfyve
Phosphatidylinositol 3-phosphate 5-kinase type III
Short name:
PIPkin-III
Short name:
Type III PIP kinase
Gene namesi
Name:PIKFYVE
Synonyms:KIAA0981, PIP5K3
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 2

Organism-specific databases

EuPathDBiHostDB:ENSG00000115020.16
HGNCiHGNC:23785 PIKFYVE
MIMi609414 gene
neXtProtiNX_Q9Y2I7

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Endosome, Membrane

Pathology & Biotechi

Involvement in diseasei

Corneal dystrophy, fleck (CFD)1 Publication
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA form of stromal corneal dystrophy characterized by numerous small white flecks scattered in all levels of the stroma, with configurations varying from semicircular to wreath-like, curvilinear, or punctate. Although CFD may occasionally cause mild photophobia, patients are typically asymptomatic and have normal vision.
See also OMIM:121850
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_0253091103K → R in CFD. 1 PublicationCorresponds to variant dbSNP:rs121918336EnsemblClinVar.1

Keywords - Diseasei

Corneal dystrophy, Disease mutation

Organism-specific databases

DisGeNETi200576
MalaCardsiPIKFYVE
MIMi121850 phenotype
OpenTargetsiENSG00000115020
Orphaneti98970 Fleck corneal dystrophy
PharmGKBiPA165697116

Chemistry databases

ChEMBLiCHEMBL1938222
GuidetoPHARMACOLOGYi2857

Polymorphism and mutation databases

BioMutaiPIKFYVE
DMDMi300669693

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedCombined sources
ChainiPRO_00001854522 – 20981-phosphatidylinositol 3-phosphate 5-kinaseAdd BLAST2097

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineCombined sources1
Modified residuei48PhosphoserineCombined sources1
Modified residuei88PhosphoserineCombined sources1
Modified residuei299PhosphoserineCombined sources1
Modified residuei307PhosphoserineCombined sources1
Modified residuei312PhosphoserineBy similarity1
Modified residuei318Phosphoserine; by PKB/AKT1 or PKB/AKT21 Publication1
Modified residuei329PhosphoserineCombined sources1
Modified residuei475PhosphoserineBy similarity1
Modified residuei1544PhosphoserineCombined sources1
Modified residuei1549PhosphoserineCombined sources1
Modified residuei1754PhosphoserineCombined sources1

Post-translational modificationi

Phosphorylated in response to insulin at Ser-318 in a protein kinase B (PKB)-dependent manner.1 Publication

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiQ9Y2I7
PaxDbiQ9Y2I7
PeptideAtlasiQ9Y2I7
PRIDEiQ9Y2I7
ProteomicsDBi85801
85802 [Q9Y2I7-2]
85803 [Q9Y2I7-3]
85804 [Q9Y2I7-4]

PTM databases

iPTMnetiQ9Y2I7
PhosphoSitePlusiQ9Y2I7

Expressioni

Gene expression databases

BgeeiENSG00000115020 Expressed in 230 organ(s), highest expression level in secondary oocyte
CleanExiHS_PIP5K3
ExpressionAtlasiQ9Y2I7 baseline and differential
GenevisibleiQ9Y2I7 HS

Organism-specific databases

HPAiHPA042604

Interactioni

Subunit structurei

Component of the PI(3,5)P2 regulatory complex/PAS complex, at least composed of PIKFYVE, FIG4 and VAC14. VAC14 nucleates the assembly of the complex and serves as a scaffold.2 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
VAC14Q08AM64EBI-6138650,EBI-2107455

Protein-protein interaction databases

BioGridi128336, 15 interactors
CORUMiQ9Y2I7
IntActiQ9Y2I7, 6 interactors
MINTiQ9Y2I7
STRINGi9606.ENSP00000264380

Structurei

3D structure databases

ProteinModelPortaliQ9Y2I7
SMRiQ9Y2I7
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini365 – 440DEPPROSITE-ProRule annotationAdd BLAST76
Domaini1758 – 2084PIPKPROSITE-ProRule annotationAdd BLAST327

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni1842 – 2098CatalyticAdd BLAST257

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri158 – 218FYVE-typePROSITE-ProRule annotationAdd BLAST61

Keywords - Domaini

Zinc-finger

Phylogenomic databases

eggNOGiENOG410IMP3 Eukaryota
KOG0230 Eukaryota
COG0459 LUCA
COG5253 LUCA
GeneTreeiENSGT00840000129741
HOGENOMiHOG000059273
HOVERGENiHBG005775
InParanoidiQ9Y2I7
KOiK00921
OMAiWKKICHH
OrthoDBiEOG091G00JB
PhylomeDBiQ9Y2I7
TreeFamiTF321717

Family and domain databases

CDDicd04448 DEP_PIKfyve, 1 hit
Gene3Di1.10.10.10, 1 hit
3.30.40.10, 1 hit
3.30.800.10, 1 hit
3.50.7.10, 1 hit
InterProiView protein in InterPro
IPR002423 Cpn60/TCP-1
IPR000591 DEP_dom
IPR027409 GroEL-like_apical_dom_sf
IPR037378 PIKfyve_DEP
IPR002498 PInositol-4-P-5-kinase_core
IPR027484 PInositol-4-P-5-kinase_N
IPR027410 TCP-1-like_intermed_sf
IPR036388 WH-like_DNA-bd_sf
IPR036390 WH_DNA-bd_sf
IPR000306 Znf_FYVE
IPR017455 Znf_FYVE-rel
IPR011011 Znf_FYVE_PHD
IPR013083 Znf_RING/FYVE/PHD
PfamiView protein in Pfam
PF00118 Cpn60_TCP1, 1 hit
PF00610 DEP, 1 hit
PF01363 FYVE, 1 hit
PF01504 PIP5K, 2 hits
SMARTiView protein in SMART
SM00049 DEP, 1 hit
SM00064 FYVE, 1 hit
SM00330 PIPKc, 1 hit
SUPFAMiSSF46785 SSF46785, 1 hit
SSF52029 SSF52029, 1 hit
SSF54849 SSF54849, 2 hits
SSF57903 SSF57903, 1 hit
PROSITEiView protein in PROSITE
PS50186 DEP, 1 hit
PS51455 PIPK, 1 hit
PS50178 ZF_FYVE, 1 hit

Sequences (4+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 4 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 4 described isoforms and 3 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q9Y2I7-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MATDDKTSPT LDSANDLPRS PTSPSHLTHF KPLTPDQDEP PFKSAYSSFV
60 70 80 90 100
NLFRFNKERA EGGQGEQQPL SGSWTSPQLP SRTQSVRSPT PYKKQLNEEL
110 120 130 140 150
QRRSSALDTR RKAEPTFGGH DPRTAVQLRS LSTVLKRLKE IMEGKSQDSD
160 170 180 190 200
LKQYWMPDSQ CKECYDCSEK FTTFRRRHHC RLCGQIFCSR CCNQEIPGKF
210 220 230 240 250
MGYTGDLRAC TYCRKIALSY AHSTDSNSIG EDLNALSDSA CSVSVLDPSE
260 270 280 290 300
PRTPVGSRKA SRNIFLEDDL AWQSLIHPDS SNTPLSTRLV SVQEDAGKSP
310 320 330 340 350
ARNRSASITN LSLDRSGSPM VPSYETSVSP QANRTYVRTE TTEDERKILL
360 370 380 390 400
DSVQLKDLWK KICHHSSGME FQDHRYWLRT HPNCIVGKEL VNWLIRNGHI
410 420 430 440 450
ATRAQAIAIG QAMVDGRWLD CVSHHDQLFR DEYALYRPLQ STEFSETPSP
460 470 480 490 500
DSDSVNSVEG HSEPSWFKDI KFDDSDTEQI AEEGDDNLAN SASPSKRTSV
510 520 530 540 550
SSFQSTVDSD SAASISLNVE LDNVNFHIKK PSKYPHVPPH PADQKEYLIS
560 570 580 590 600
DTGGQQLSIS DAFIKESLFN RRVEEKSKEL PFTPLGWHHN NLELLREENG
610 620 630 640 650
EKQAMERLLS ANHNHMMALL QQLLHSDSLS SSWRDIIVSL VCQVVQTVRP
660 670 680 690 700
DVKNQDDDMD IRQFVHIKKI PGGKKFDSVV VNGFVCTKNI AHKKMSSCIK
710 720 730 740 750
NPKILLLKCS IEYLYREETK FTCIDPIVLQ EREFLKNYVQ RIVDVRPTLV
760 770 780 790 800
LVEKTVSRIA QDMLLEHGIT LVINVKSQVL ERISRMTQGD LVMSMDQLLT
810 820 830 840 850
KPHLGTCHKF YMQIFQLPNE QTKTLMFFEG CPQHLGCTIK LRGGSDYELA
860 870 880 890 900
RVKEILIFMI CVAYHSQLEI SFLMDEFAMP PTLMQNPSFH SLIEGRGHEG
910 920 930 940 950
AVQEQYGGGS IPWDPDIPPE SLPCDDSSLL ELRIVFEKGE QENKNLPQAV
960 970 980 990 1000
ASVKHQEHST TACPAGLPCA FFAPVPESLL PLPVDDQQDA LGSEQPETLQ
1010 1020 1030 1040 1050
QTVVLQDPKS QIRAFRDPLQ DDTGLYVTEE VTSSEDKRKT YSLAFKQELK
1060 1070 1080 1090 1100
DVILCISPVI TFREPFLLTE KGMRCSTRDY FAEQVYWSPL LNKEFKEMEN
1110 1120 1130 1140 1150
RRKKQLLRDL SGLQGMNGSI QAKSIQVLPS HELVSTRIAE HLGDSQSLGR
1160 1170 1180 1190 1200
MLADYRARGG RIQPKNSDPF AHSKDASSTS SGQSGSKNEG DEERGLILSD
1210 1220 1230 1240 1250
AVWSTKVDCL NPINHQRLCV LFSSSSAQSS NAPSACVSPW IVTMEFYGKN
1260 1270 1280 1290 1300
DLTLGIFLER YCFRPSYQCP SMFCDTPMVH HIRRFVHGQG CVQIILKELD
1310 1320 1330 1340 1350
SPVPGYQHTI LTYSWCRICK QVTPVVALSN ESWSMSFAKY LELRFYGHQY
1360 1370 1380 1390 1400
TRRANAEPCG HSIHHDYHQY FSYNQMVASF SYSPIRLLEV CVPLPKIFIK
1410 1420 1430 1440 1450
RQAPLKVSLL QDLKDFFQKV SQVYVAIDER LASLKTDTFS KTREEKMEDI
1460 1470 1480 1490 1500
FAQKEMEEGE FKNWIEKMQA RLMSSSVDTP QQLQSVFESL IAKKQSLCEV
1510 1520 1530 1540 1550
LQAWNNRLQD LFQQEKGRKR PSVPPSPGRL RQGEESKISA MDASPRNISP
1560 1570 1580 1590 1600
GLQNGEKEDR FLTTLSSQSS TSSTHLQLPT PPEVMSEQSV GGPPELDTAS
1610 1620 1630 1640 1650
SSEDVFDGHL LGSTDSQVKE KSTMKAIFAN LLPGNSYNPI PFPFDPDKHY
1660 1670 1680 1690 1700
LMYEHERVPI AVCEKEPSSI IAFALSCKEY RNALEELSKA TQWNSAEEGL
1710 1720 1730 1740 1750
PTNSTSDSRP KSSSPIRLPE MSGGQTNRTT ETEPQPTKKA SGMLSFFRGT
1760 1770 1780 1790 1800
AGKSPDLSSQ KRETLRGADS AYYQVGQTGK EGTENQGVEP QDEVDGGDTQ
1810 1820 1830 1840 1850
KKQLINPHVE LQFSDANAKF YCRLYYAGEF HKMREVILDS SEEDFIRSLS
1860 1870 1880 1890 1900
HSSPWQARGG KSGAAFYATE DDRFILKQMP RLEVQSFLDF APHYFNYITN
1910 1920 1930 1940 1950
AVQQKRPTAL AKILGVYRIG YKNSQNNTEK KLDLLVMENL FYGRKMAQVF
1960 1970 1980 1990 2000
DLKGSLRNRN VKTDTGKESC DVVLLDENLL KMVRDNPLYI RSHSKAVLRT
2010 2020 2030 2040 2050
SIHSDSHFLS SHLIIDYSLL VGRDDTSNEL VVGIIDYIRT FTWDKKLEMV
2060 2070 2080 2090
VKSTGILGGQ GKMPTVVSPE LYRTRFCEAM DKYFLMVPDH WTGLGLNC
Length:2,098
Mass (Da):237,136
Last modified:July 13, 2010 - v3
Checksum:i390C43530D3B1E81
GO
Isoform 2 (identifier: Q9Y2I7-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     108-204: Missing.
     546-548: EYL → GRR
     549-2098: Missing.

Note: No experimental confirmation available.
Show »
Length:451
Mass (Da):50,211
Checksum:iE5C7D123475EA30E
GO
Isoform 3 (identifier: Q9Y2I7-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     109-203: TRRKAEPTFG...QEIPGKFMGY → NSLQHPQEN
     546-548: EYL → GRR
     549-2098: Missing.

Note: No experimental confirmation available.
Show »
Length:462
Mass (Da):51,476
Checksum:i60E516304C47A038
GO
Isoform 4 (identifier: Q9Y2I7-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     546-548: EYL → GRR
     549-2098: Missing.

Note: No experimental confirmation available.
Show »
Length:548
Mass (Da):61,595
Checksum:i46091F5266458F67
GO

Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E9PDH4E9PDH4_HUMAN
1-phosphatidylinositol 3-phosphate ...
PIKFYVE
1,384Annotation score:
C9JL08C9JL08_HUMAN
1-phosphatidylinositol 3-phosphate ...
PIKFYVE
241Annotation score:
F8WEZ0F8WEZ0_HUMAN
1-phosphatidylinositol 3-phosphate ...
PIKFYVE
158Annotation score:

Sequence cautioni

The sequence BAC03674 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti1335M → I in BAC03674 (PubMed:14702039).Curated1
Sequence conflicti2019L → S in BAC03674 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_057097617M → V. Corresponds to variant dbSNP:rs16840913EnsemblClinVar.1
Natural variantiVAR_063406696S → N2 PublicationsCorresponds to variant dbSNP:rs10932258EnsemblClinVar.1
Natural variantiVAR_063407932L → S2 PublicationsCorresponds to variant dbSNP:rs2363468EnsemblClinVar.1
Natural variantiVAR_063408995Q → L2 PublicationsCorresponds to variant dbSNP:rs893254EnsemblClinVar.1
Natural variantiVAR_063409998T → S2 PublicationsCorresponds to variant dbSNP:rs893253EnsemblClinVar.1
Natural variantiVAR_0570981033S → A. Corresponds to variant dbSNP:rs999890EnsemblClinVar.1
Natural variantiVAR_0253091103K → R in CFD. 1 PublicationCorresponds to variant dbSNP:rs121918336EnsemblClinVar.1
Natural variantiVAR_0634101183Q → K3 PublicationsCorresponds to variant dbSNP:rs1529979EnsemblClinVar.1
Natural variantiVAR_0570991858R → Q. Corresponds to variant dbSNP:rs2289170EnsemblClinVar.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_040108108 – 204Missing in isoform 2. 1 PublicationAdd BLAST97
Alternative sequenceiVSP_040109109 – 203TRRKA…KFMGY → NSLQHPQEN in isoform 3. 1 PublicationAdd BLAST95
Alternative sequenceiVSP_040110546 – 548EYL → GRR in isoform 2, isoform 3 and isoform 4. 1 Publication3
Alternative sequenceiVSP_040111549 – 2098Missing in isoform 2, isoform 3 and isoform 4. 1 PublicationAdd BLAST1550

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY457063 mRNA Translation: AAR19397.1
AC012362 Genomic DNA Translation: AAY14870.1
AC016697 Genomic DNA Translation: AAX93222.1
CH471063 Genomic DNA Translation: EAW70444.1
CH471063 Genomic DNA Translation: EAW70445.1
BC032389 mRNA Translation: AAH32389.1
BC125052 mRNA Translation: AAI25053.1
BC125053 mRNA Translation: AAI25054.1
AK091482 mRNA Translation: BAC03674.1 Different initiation.
AB023198 mRNA Translation: BAA76825.1
CCDSiCCDS2382.1 [Q9Y2I7-1]
CCDS33368.1 [Q9Y2I7-2]
CCDS54431.1 [Q9Y2I7-4]
RefSeqiNP_001171471.1, NM_001178000.1 [Q9Y2I7-4]
NP_055855.2, NM_015040.3 [Q9Y2I7-1]
NP_689884.1, NM_152671.3 [Q9Y2I7-2]
UniGeneiHs.744997

Genome annotation databases

EnsembliENST00000264380; ENSP00000264380; ENSG00000115020 [Q9Y2I7-1]
ENST00000308862; ENSP00000308715; ENSG00000115020 [Q9Y2I7-3]
ENST00000392202; ENSP00000376038; ENSG00000115020 [Q9Y2I7-2]
ENST00000407449; ENSP00000384356; ENSG00000115020 [Q9Y2I7-4]
GeneIDi200576
KEGGihsa:200576
UCSCiuc002vcv.4 human [Q9Y2I7-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY457063 mRNA Translation: AAR19397.1
AC012362 Genomic DNA Translation: AAY14870.1
AC016697 Genomic DNA Translation: AAX93222.1
CH471063 Genomic DNA Translation: EAW70444.1
CH471063 Genomic DNA Translation: EAW70445.1
BC032389 mRNA Translation: AAH32389.1
BC125052 mRNA Translation: AAI25053.1
BC125053 mRNA Translation: AAI25054.1
AK091482 mRNA Translation: BAC03674.1 Different initiation.
AB023198 mRNA Translation: BAA76825.1
CCDSiCCDS2382.1 [Q9Y2I7-1]
CCDS33368.1 [Q9Y2I7-2]
CCDS54431.1 [Q9Y2I7-4]
RefSeqiNP_001171471.1, NM_001178000.1 [Q9Y2I7-4]
NP_055855.2, NM_015040.3 [Q9Y2I7-1]
NP_689884.1, NM_152671.3 [Q9Y2I7-2]
UniGeneiHs.744997

3D structure databases

ProteinModelPortaliQ9Y2I7
SMRiQ9Y2I7
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi128336, 15 interactors
CORUMiQ9Y2I7
IntActiQ9Y2I7, 6 interactors
MINTiQ9Y2I7
STRINGi9606.ENSP00000264380

Chemistry databases

ChEMBLiCHEMBL1938222
GuidetoPHARMACOLOGYi2857

PTM databases

iPTMnetiQ9Y2I7
PhosphoSitePlusiQ9Y2I7

Polymorphism and mutation databases

BioMutaiPIKFYVE
DMDMi300669693

Proteomic databases

EPDiQ9Y2I7
PaxDbiQ9Y2I7
PeptideAtlasiQ9Y2I7
PRIDEiQ9Y2I7
ProteomicsDBi85801
85802 [Q9Y2I7-2]
85803 [Q9Y2I7-3]
85804 [Q9Y2I7-4]

Protocols and materials databases

DNASUi200576
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000264380; ENSP00000264380; ENSG00000115020 [Q9Y2I7-1]
ENST00000308862; ENSP00000308715; ENSG00000115020 [Q9Y2I7-3]
ENST00000392202; ENSP00000376038; ENSG00000115020 [Q9Y2I7-2]
ENST00000407449; ENSP00000384356; ENSG00000115020 [Q9Y2I7-4]
GeneIDi200576
KEGGihsa:200576
UCSCiuc002vcv.4 human [Q9Y2I7-1]

Organism-specific databases

CTDi200576
DisGeNETi200576
EuPathDBiHostDB:ENSG00000115020.16
GeneCardsiPIKFYVE
HGNCiHGNC:23785 PIKFYVE
HPAiHPA042604
MalaCardsiPIKFYVE
MIMi121850 phenotype
609414 gene
neXtProtiNX_Q9Y2I7
OpenTargetsiENSG00000115020
Orphaneti98970 Fleck corneal dystrophy
PharmGKBiPA165697116
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IMP3 Eukaryota
KOG0230 Eukaryota
COG0459 LUCA
COG5253 LUCA
GeneTreeiENSGT00840000129741
HOGENOMiHOG000059273
HOVERGENiHBG005775
InParanoidiQ9Y2I7
KOiK00921
OMAiWKKICHH
OrthoDBiEOG091G00JB
PhylomeDBiQ9Y2I7
TreeFamiTF321717

Enzyme and pathway databases

BioCyciMetaCyc:HS03825-MONOMER
BRENDAi2.7.1.150 2681
2.7.1.68 2681
ReactomeiR-HSA-1660514 Synthesis of PIPs at the Golgi membrane
R-HSA-1660516 Synthesis of PIPs at the early endosome membrane
R-HSA-1660517 Synthesis of PIPs at the late endosome membrane
SIGNORiQ9Y2I7

Miscellaneous databases

ChiTaRSiPIKFYVE human
GeneWikiiPIKFYVE
GenomeRNAii200576
PROiPR:Q9Y2I7
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000115020 Expressed in 230 organ(s), highest expression level in secondary oocyte
CleanExiHS_PIP5K3
ExpressionAtlasiQ9Y2I7 baseline and differential
GenevisibleiQ9Y2I7 HS

Family and domain databases

CDDicd04448 DEP_PIKfyve, 1 hit
Gene3Di1.10.10.10, 1 hit
3.30.40.10, 1 hit
3.30.800.10, 1 hit
3.50.7.10, 1 hit
InterProiView protein in InterPro
IPR002423 Cpn60/TCP-1
IPR000591 DEP_dom
IPR027409 GroEL-like_apical_dom_sf
IPR037378 PIKfyve_DEP
IPR002498 PInositol-4-P-5-kinase_core
IPR027484 PInositol-4-P-5-kinase_N
IPR027410 TCP-1-like_intermed_sf
IPR036388 WH-like_DNA-bd_sf
IPR036390 WH_DNA-bd_sf
IPR000306 Znf_FYVE
IPR017455 Znf_FYVE-rel
IPR011011 Znf_FYVE_PHD
IPR013083 Znf_RING/FYVE/PHD
PfamiView protein in Pfam
PF00118 Cpn60_TCP1, 1 hit
PF00610 DEP, 1 hit
PF01363 FYVE, 1 hit
PF01504 PIP5K, 2 hits
SMARTiView protein in SMART
SM00049 DEP, 1 hit
SM00064 FYVE, 1 hit
SM00330 PIPKc, 1 hit
SUPFAMiSSF46785 SSF46785, 1 hit
SSF52029 SSF52029, 1 hit
SSF54849 SSF54849, 2 hits
SSF57903 SSF57903, 1 hit
PROSITEiView protein in PROSITE
PS50186 DEP, 1 hit
PS51455 PIPK, 1 hit
PS50178 ZF_FYVE, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiFYV1_HUMAN
AccessioniPrimary (citable) accession number: Q9Y2I7
Secondary accession number(s): Q08AR7
, Q08AR8, Q53ST3, Q53T36, Q8N5H0, Q8NB67
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: July 13, 2010
Last modified: October 10, 2018
This is version 182 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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