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Entry version 171 (11 Dec 2019)
Sequence version 3 (04 Jan 2005)
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Protein

Netrin-G1

Gene

NTNG1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Involved in controlling patterning and neuronal circuit formation at the laminar, cellular, subcellular and synaptic levels. Promotes neurite outgrowth of both axons and dendrites.1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • cell adhesion molecule binding Source: SynGO-UCL
  • cell-cell adhesion mediator activity Source: SynGO-UCL

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDevelopmental protein
Biological processDifferentiation, Neurogenesis

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-163125 Post-translational modification: synthesis of GPI-anchored proteins

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Netrin-G1
Alternative name(s):
Laminet-1
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:NTNG1
Synonyms:KIAA0976, LMNT1
ORF Names:UNQ571/PRO1133
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 1

Organism-specific databases

Eukaryotic Pathogen Database Resources

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EuPathDBi
HostDB:ENSG00000162631.18

Human Gene Nomenclature Database

More...
HGNCi
HGNC:23319 NTNG1

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
608818 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q9Y2I2

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell membrane, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
22854

MalaCards human disease database

More...
MalaCardsi
NTNG1

Open Targets

More...
OpenTargetsi
ENSG00000162631

Orphanet; a database dedicated to information on rare diseases and orphan drugs

More...
Orphaneti
3095 Atypical Rett syndrome

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA164742200

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q9Y2I2 Tbio

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
NTNG1

Domain mapping of disease mutations (DMDM)

More...
DMDMi
57015420

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 281 PublicationAdd BLAST28
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000001709129 – 510Netrin-G1Add BLAST482
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section describes a propeptide, which is a part of a protein that is cleaved during maturation or activation. Once cleaved, a propeptide generally has no independent biological function.<p><a href='/help/propep' target='_top'>More...</a></p>PropeptideiPRO_0000017092511 – 539Removed in mature formSequence analysisAdd BLAST29

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi33 ↔ 50By similarity
Disulfide bondi72 ↔ 92By similarity
Disulfide bondi80 ↔ 88
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi133N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi182 ↔ 206By similarity
Disulfide bondi297 ↔ 306By similarity
Disulfide bondi299 ↔ 315By similarity
Disulfide bondi317 ↔ 326By similarity
Glycosylationi320N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi329 ↔ 354By similarity
Disulfide bondi364 ↔ 373By similarity
Disulfide bondi366 ↔ 384By similarity
Disulfide bondi387 ↔ 396By similarity
Disulfide bondi399 ↔ 417By similarity
Glycosylationi406N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi420 ↔ 432By similarity
Disulfide bondi422 ↔ 438By similarity
Glycosylationi433N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi440 ↔ 449By similarity
Disulfide bondi452 ↔ 462By similarity
Disulfide bondi467 ↔ 480By similarity
Disulfide bondi474 ↔ 486By similarity
Disulfide bondi488 ↔ 497By similarity
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position(s) and the type of covalently attached lipid group(s).<p><a href='/help/lipid' target='_top'>More...</a></p>Lipidationi510GPI-anchor amidated serineSequence analysis1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

N-glycosylated.By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein, GPI-anchor, Lipoprotein

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

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jPOSTi
Q9Y2I2

MassIVE - Mass Spectrometry Interactive Virtual Environment

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MassIVEi
Q9Y2I2

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q9Y2I2

PeptideAtlas

More...
PeptideAtlasi
Q9Y2I2

PRoteomics IDEntifications database

More...
PRIDEi
Q9Y2I2

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
85793 [Q9Y2I2-3]
85794 [Q9Y2I2-1]
85795 [Q9Y2I2-2]
85796 [Q9Y2I2-4]
85797 [Q9Y2I2-5]
85798 [Q9Y2I2-6]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q9Y2I2

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q9Y2I2

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Highly expressed in the thalamus, with very low expression, if any, in other tissues.2 Publications

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000162631 Expressed in 129 organ(s), highest expression level in lateral nuclear group of thalamus

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q9Y2I2 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q9Y2I2 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA065954

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with NGL1.

2 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Show more details

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

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BioGridi
116525, 3 interactors

Protein interaction database and analysis system

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IntActi
Q9Y2I2, 5 interactors

Molecular INTeraction database

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MINTi
Q9Y2I2

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000359085

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q9Y2I2 protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1539
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q9Y2I2

Database of comparative protein structure models

More...
ModBasei
Search...

Protein Data Bank in Europe - Knowledge Base

More...
PDBe-KBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini46 – 296Laminin N-terminalPROSITE-ProRule annotationAdd BLAST251
Domaini297 – 356Laminin EGF-like 1PROSITE-ProRule annotationAdd BLAST60
Domaini364 – 419Laminin EGF-like 2PROSITE-ProRule annotationAdd BLAST56
Domaini420 – 469Laminin EGF-like 3PROSITE-ProRule annotationAdd BLAST50

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni80 – 91NGL discriminant loop IAdd BLAST12
Regioni208 – 214NGL discriminant loop II7
Regioni273 – 275NGL discriminant loop III3

<p>This subsection of the ‘Family and domains’ section provides general information on the biological role of a domain. The term ‘domain’ is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The laminin N-terminal domain mediates 1:1 binding to NGL ligand with sub-micromolar affinity. Three NGL-binding loops mediate discrimination for LRRC4C/NGL1 among other NGLs by binding specifically to its LRR repeats. This specificity drives the sorting of a mixed population of molecules into discrete cell surface subdomains.

Keywords - Domaini

Laminin EGF-like domain, Repeat, Signal

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1836 Eukaryota
KOG3512 Eukaryota
ENOG410XS7U LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000153601

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q9Y2I2

KEGG Orthology (KO)

More...
KOi
K07522

Identification of Orthologs from Complete Genome Data

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OMAi
CKEENKR

Database of Orthologous Groups

More...
OrthoDBi
117497at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q9Y2I2

TreeFam database of animal gene trees

More...
TreeFami
TF333945

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.60.120.1490, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR013032 EGF-like_CS
IPR000742 EGF-like_dom
IPR002049 Laminin_EGF
IPR008211 Laminin_N
IPR038684 Laminin_N_sf

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00053 Laminin_EGF, 3 hits
PF00055 Laminin_N, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00181 EGF, 2 hits
SM00180 EGF_Lam, 3 hits
SM00136 LamNT, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00022 EGF_1, 3 hits
PS50026 EGF_3, 1 hit
PS01248 EGF_LAM_1, 1 hit
PS50027 EGF_LAM_2, 3 hits
PS51117 LAMININ_NTER, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (6)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 6 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
Isoform 3 (identifier: Q9Y2I2-3) [UniParc]FASTAAdd to basket
Also known as: 1A

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MYLSRFLSIH ALWVTVSSVM QPYPLVWGHY DLCKTQIYTE EGKVWDYMAC
60 70 80 90 100
QPESTDMTKY LKVKLDPPDI TCGDPPETFC AMGNPYMCNN ECDASTPELA
110 120 130 140 150
HPPELMFDFE GRHPSTFWQS ATWKEYPKPL QVNITLSWSK TIELTDNIVI
160 170 180 190 200
TFESGRPDQM ILEKSLDYGR TWQPYQYYAT DCLDAFHMDP KSVKDLSQHT
210 220 230 240 250
VLEIICTEEY STGYTTNSKI IHFEIKDRFA FFAGPRLRNM ASLYGQLDTT
260 270 280 290 300
KKLRDFFTVT DLRIRLLRPA VGEIFVDELH LARYFYAISD IKVRGRCKCN
310 320 330 340 350
LHATVCVYDN SKLTCECEHN TTGPDCGKCK KNYQGRPWSP GSYLPIPKGT
360 370 380 390 400
ANTCIPSISS IGNCECFGHS NRCSYIDLLN TVICVSCKHN TRGQHCELCR
410 420 430 440 450
LGYFRNASAQ LDDENVCIEC YCNPLGSIHD RCNGSGFCEC KTGTTGPKCD
460 470 480 490 500
ECLPGNSWHY GCQPNVCDNE LLHCQNGGTC HNNVRCLCPA AYTGILCEKL
510 520 530
RCEEAGSCGS DSGQGAPPHG SPALLLLTTL LGTASPLVF
Note: Mostly expressed in adult brain.
Length:539
Mass (Da):60,541
Last modified:January 4, 2005 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iC51F872D7A2C60A6
GO
Isoform 2 (identifier: Q9Y2I2-2) [UniParc]FASTAAdd to basket
Also known as: 1F

The sequence of this isoform differs from the canonical sequence as follows:
     363-364: NC → SK
     365-539: Missing.

Show »
Length:364
Mass (Da):41,759
Checksum:iB23DAF4BEDE9271C
GO
Isoform 1 (identifier: Q9Y2I2-1) [UniParc]FASTAAdd to basket
Also known as: 1C

The sequence of this isoform differs from the canonical sequence as follows:
     363-463: Missing.
     464-464: P → T

Note: Hi expression in Expressed in brain and.Curated
Show »
Length:438
Mass (Da):49,340
Checksum:iBBBA6167FAC8DD71
GO
Isoform 4 (identifier: Q9Y2I2-4) [UniParc]FASTAAdd to basket
Also known as: 1D

The sequence of this isoform differs from the canonical sequence as follows:
     364-464: CECFGHSNRC...GNSWHYGCQP → PPKFNRIWPN...SVQVANHKRA

Note: Mostly expressed in kidney, also expressed in adult and fetal brain.Curated
Show »
Length:480
Mass (Da):53,946
Checksum:i9099C3CF4D3F7B86
GO
Isoform 5 (identifier: Q9Y2I2-5) [UniParc]FASTAAdd to basket
Also known as: 1E

The sequence of this isoform differs from the canonical sequence as follows:
     364-385: CECFGHSNRCSYIDLLNTVICV → PPKFNRIWPNISSLEVSNPKQA
     386-464: Missing.

Note: Some expression in fetal brain.Curated
Show »
Length:460
Mass (Da):51,858
Checksum:i8217255F4C8C4C65
GO
Isoform 6 (identifier: Q9Y2I2-6) [UniParc]FASTAAdd to basket
Also known as: 1G

The sequence of this isoform differs from the canonical sequence as follows:
     419-463: Missing.
     464-464: P → A

Show »
Length:494
Mass (Da):55,660
Checksum:iF6783893CC0FE0D8
GO

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence BAA76820 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti6F → S in AAQ88731 (PubMed:12975309).Curated1
Sequence conflicti231F → L in AAQ88731 (PubMed:12975309).Curated1
Sequence conflicti521S → T in AAQ88731 (PubMed:12975309).Curated1
Isoform 2 (identifier: Q9Y2I2-2)
Sequence conflicti364K → KQ in CAD98143 (PubMed:17974005).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_012574363 – 463Missing in isoform 1. 2 PublicationsAdd BLAST101
Alternative sequenceiVSP_010429363 – 364NC → SK in isoform 2. 2 Publications2
Alternative sequenceiVSP_012575364 – 464CECFG…YGCQP → PPKFNRIWPNISSLEVSNPK QVAPKLALSTVSSVQVANHK RA in isoform 4. CuratedAdd BLAST101
Alternative sequenceiVSP_012576364 – 385CECFG…TVICV → PPKFNRIWPNISSLEVSNPK QA in isoform 5. CuratedAdd BLAST22
Alternative sequenceiVSP_010430365 – 539Missing in isoform 2. 2 PublicationsAdd BLAST175
Alternative sequenceiVSP_012577386 – 464Missing in isoform 5. CuratedAdd BLAST79
Alternative sequenceiVSP_012578419 – 463Missing in isoform 6. CuratedAdd BLAST45
Alternative sequenceiVSP_012579464P → T in isoform 1. 2 Publications1
Alternative sequenceiVSP_012580464P → A in isoform 6. Curated1

Sequence databases

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EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
AB023193 mRNA Translation: BAA76820.2 Different initiation.
AY358365 mRNA Translation: AAQ88731.1
BX538348 mRNA Translation: CAD98143.1
AC114491 Genomic DNA No translation available.
AL513187 Genomic DNA No translation available.
AL590427 Genomic DNA No translation available.
BC030220 mRNA Translation: AAH30220.1

The Consensus CDS (CCDS) project

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CCDSi
CCDS30785.1 [Q9Y2I2-1]
CCDS44179.1 [Q9Y2I2-4]
CCDS44180.1 [Q9Y2I2-3]
CCDS81354.1 [Q9Y2I2-5]

NCBI Reference Sequences

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RefSeqi
NP_001106697.1, NM_001113226.2 [Q9Y2I2-3]
NP_001106699.1, NM_001113228.2 [Q9Y2I2-4]
NP_001317594.1, NM_001330665.1 [Q9Y2I2-5]
NP_055732.2, NM_014917.3 [Q9Y2I2-1]
XP_006710519.1, XM_006710456.3
XP_011539323.1, XM_011541021.1
XP_016856169.1, XM_017000680.1
XP_016856170.1, XM_017000681.1
XP_016856174.1, XM_017000685.1
XP_016856175.1, XM_017000686.1 [Q9Y2I2-2]

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENST00000370065; ENSP00000359082; ENSG00000162631 [Q9Y2I2-6]
ENST00000370066; ENSP00000359083; ENSG00000162631 [Q9Y2I2-4]
ENST00000370067; ENSP00000359084; ENSG00000162631 [Q9Y2I2-5]
ENST00000370068; ENSP00000359085; ENSG00000162631 [Q9Y2I2-3]
ENST00000370071; ENSP00000359088; ENSG00000162631 [Q9Y2I2-4]
ENST00000370073; ENSP00000359090; ENSG00000162631 [Q9Y2I2-3]
ENST00000370074; ENSP00000359091; ENSG00000162631 [Q9Y2I2-1]

Database of genes from NCBI RefSeq genomes

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GeneIDi
22854

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:22854

UCSC genome browser

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UCSCi
uc001dvc.4 human [Q9Y2I2-3]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB023193 mRNA Translation: BAA76820.2 Different initiation.
AY358365 mRNA Translation: AAQ88731.1
BX538348 mRNA Translation: CAD98143.1
AC114491 Genomic DNA No translation available.
AL513187 Genomic DNA No translation available.
AL590427 Genomic DNA No translation available.
BC030220 mRNA Translation: AAH30220.1
CCDSiCCDS30785.1 [Q9Y2I2-1]
CCDS44179.1 [Q9Y2I2-4]
CCDS44180.1 [Q9Y2I2-3]
CCDS81354.1 [Q9Y2I2-5]
RefSeqiNP_001106697.1, NM_001113226.2 [Q9Y2I2-3]
NP_001106699.1, NM_001113228.2 [Q9Y2I2-4]
NP_001317594.1, NM_001330665.1 [Q9Y2I2-5]
NP_055732.2, NM_014917.3 [Q9Y2I2-1]
XP_006710519.1, XM_006710456.3
XP_011539323.1, XM_011541021.1
XP_016856169.1, XM_017000680.1
XP_016856170.1, XM_017000681.1
XP_016856174.1, XM_017000685.1
XP_016856175.1, XM_017000686.1 [Q9Y2I2-2]

3D structure databases

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Protein Data Bank Europe

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PDBei

Protein Data Bank RCSB

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RCSB PDBi

Protein Data Bank Japan

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PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3ZYJX-ray3.25B/D1-520[»]
SMRiQ9Y2I2
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGridi116525, 3 interactors
IntActiQ9Y2I2, 5 interactors
MINTiQ9Y2I2
STRINGi9606.ENSP00000359085

PTM databases

iPTMnetiQ9Y2I2
PhosphoSitePlusiQ9Y2I2

Polymorphism and mutation databases

BioMutaiNTNG1
DMDMi57015420

Proteomic databases

jPOSTiQ9Y2I2
MassIVEiQ9Y2I2
PaxDbiQ9Y2I2
PeptideAtlasiQ9Y2I2
PRIDEiQ9Y2I2
ProteomicsDBi85793 [Q9Y2I2-3]
85794 [Q9Y2I2-1]
85795 [Q9Y2I2-2]
85796 [Q9Y2I2-4]
85797 [Q9Y2I2-5]
85798 [Q9Y2I2-6]

Protocols and materials databases

The DNASU plasmid repository

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DNASUi
22854

Genome annotation databases

EnsembliENST00000370065; ENSP00000359082; ENSG00000162631 [Q9Y2I2-6]
ENST00000370066; ENSP00000359083; ENSG00000162631 [Q9Y2I2-4]
ENST00000370067; ENSP00000359084; ENSG00000162631 [Q9Y2I2-5]
ENST00000370068; ENSP00000359085; ENSG00000162631 [Q9Y2I2-3]
ENST00000370071; ENSP00000359088; ENSG00000162631 [Q9Y2I2-4]
ENST00000370073; ENSP00000359090; ENSG00000162631 [Q9Y2I2-3]
ENST00000370074; ENSP00000359091; ENSG00000162631 [Q9Y2I2-1]
GeneIDi22854
KEGGihsa:22854
UCSCiuc001dvc.4 human [Q9Y2I2-3]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
22854
DisGeNETi22854
EuPathDBiHostDB:ENSG00000162631.18

GeneCards: human genes, protein and diseases

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GeneCardsi
NTNG1
HGNCiHGNC:23319 NTNG1
HPAiHPA065954
MalaCardsiNTNG1
MIMi608818 gene
neXtProtiNX_Q9Y2I2
OpenTargetsiENSG00000162631
Orphaneti3095 Atypical Rett syndrome
PharmGKBiPA164742200

Human Unidentified Gene-Encoded large proteins database

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HUGEi
Search...

GenAtlas: human gene database

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GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG1836 Eukaryota
KOG3512 Eukaryota
ENOG410XS7U LUCA
GeneTreeiENSGT00940000153601
InParanoidiQ9Y2I2
KOiK07522
OMAiCKEENKR
OrthoDBi117497at2759
PhylomeDBiQ9Y2I2
TreeFamiTF333945

Enzyme and pathway databases

ReactomeiR-HSA-163125 Post-translational modification: synthesis of GPI-anchored proteins

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
NTNG1 human

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
NTNG1

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
22854
PharosiQ9Y2I2 Tbio

Protein Ontology

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PROi
PR:Q9Y2I2
RNActiQ9Y2I2 protein

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
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Gene expression databases

BgeeiENSG00000162631 Expressed in 129 organ(s), highest expression level in lateral nuclear group of thalamus
ExpressionAtlasiQ9Y2I2 baseline and differential
GenevisibleiQ9Y2I2 HS

Family and domain databases

Gene3Di2.60.120.1490, 1 hit
InterProiView protein in InterPro
IPR013032 EGF-like_CS
IPR000742 EGF-like_dom
IPR002049 Laminin_EGF
IPR008211 Laminin_N
IPR038684 Laminin_N_sf
PfamiView protein in Pfam
PF00053 Laminin_EGF, 3 hits
PF00055 Laminin_N, 1 hit
SMARTiView protein in SMART
SM00181 EGF, 2 hits
SM00180 EGF_Lam, 3 hits
SM00136 LamNT, 1 hit
PROSITEiView protein in PROSITE
PS00022 EGF_1, 3 hits
PS50026 EGF_3, 1 hit
PS01248 EGF_LAM_1, 1 hit
PS50027 EGF_LAM_2, 3 hits
PS51117 LAMININ_NTER, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiNTNG1_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9Y2I2
Secondary accession number(s): Q5VU86
, Q5VU87, Q5VU89, Q5VU90, Q5VU91, Q7Z2Y3, Q8N633
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 19, 2003
Last sequence update: January 4, 2005
Last modified: December 11, 2019
This is version 171 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Direct protein sequencing, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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