UniProtKB - Q9Y2I1 (NISCH_HUMAN)
Nischarin
NISCH
Functioni
Acts either as the functional imidazoline-1 receptor (I1R) candidate or as a membrane-associated mediator of the I1R signaling. Binds numerous imidazoline ligands that induces initiation of cell-signaling cascades triggering to cell survival, growth and migration. Its activation by the agonist rilmenidine induces an increase in phosphorylation of mitogen-activated protein kinases MAPK1 and MAPK3 in rostral ventrolateral medulla (RVLM) neurons that exhibited rilmenidine-evoked hypotension (By similarity).
Blocking its activation with efaroxan abolished rilmenidine-induced mitogen-activated protein kinase phosphorylation in RVLM neurons (By similarity).
Acts as a modulator of Rac-regulated signal transduction pathways (By similarity).
Suppresses Rac1-stimulated cell migration by interacting with PAK1 and inhibiting its kinase activity (By similarity).
Also blocks Pak-independent Rac signaling by interacting with RAC1 and inhibiting Rac1-stimulated NF-kB response element and cyclin D1 promoter activation (By similarity).
Inhibits also LIMK1 kinase activity by reducing LIMK1 'Tyr-508' phosphorylation (By similarity).
Inhibits Rac-induced cell migration and invasion in breast and colon epithelial cells (By similarity).
Inhibits lamellipodia formation, when overexpressed (By similarity).
Plays a role in protection against apoptosis. Involved in association with IRS4 in the enhancement of insulin activation of MAPK1 and MAPK3. When overexpressed, induces a redistribution of cell surface ITGA5 integrin to intracellular endosomal structures.
By similarity5 PublicationsGO - Molecular functioni
- identical protein binding Source: IntAct
- integrin binding Source: Ensembl
- phosphatidylinositol binding Source: InterPro
- protein kinase binding Source: GO_Central
GO - Biological processi
- actin cytoskeleton organization Source: Ensembl
- apoptotic process Source: UniProtKB-KW
- negative regulation of cell migration Source: Ensembl
- Rac protein signal transduction Source: Ensembl
Keywordsi
Molecular function | Receptor |
Biological process | Apoptosis |
Enzyme and pathway databases
PathwayCommonsi | Q9Y2I1 |
Reactomei | R-HSA-9013149, RAC1 GTPase cycle R-HSA-9696264, RND3 GTPase cycle R-HSA-9696270, RND2 GTPase cycle |
SignaLinki | Q9Y2I1 |
Names & Taxonomyi
Protein namesi | Recommended name: NischarinAlternative name(s): Imidazoline receptor 1 Short name: I-1 Short name: IR1 Imidazoline receptor antisera-selected protein Short name: hIRAS Imidazoline-1 receptor Short name: I1R Imidazoline-1 receptor candidate protein Short name: I-1 receptor candidate protein Short name: I1R candidate protein |
Gene namesi | Name:NISCH Synonyms:IRAS, KIAA0975 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:18006, NISCH |
MIMi | 615507, gene |
neXtProti | NX_Q9Y2I1 |
VEuPathDBi | HostDB:ENSG00000010322 |
Subcellular locationi
Plasma membrane
Endosome
Cytoplasm and Cytosol
Note: Enriched in the early/sorting and recycling endosomes. Colocalized in early/sorting endosomes with EEA1 and SNX2 and in recycling endosomes with transferrin receptor. Detected in the perinuclear region partially associated with punctate structures (By similarity). Colocalizes with PAK1 in cytoplasm, vesicular structures in the perinuclear area and membrane ruffles (By similarity). Colocalizes with RAC1 in the cytoplasm and vesicles structures (By similarity). Colocalized with MAPK1 and MAPK3 in RVLM neurons (By similarity).By similarity
Cytoskeleton
- microtubule cytoskeleton Source: HPA
Cytosol
- cytosol Source: BHF-UCL
Endosome
- early endosome Source: UniProtKB-SubCell
- recycling endosome Source: UniProtKB-SubCell
Extracellular region or secreted
- intercellular bridge Source: HPA
Nucleus
- nucleoplasm Source: HPA
Plasma Membrane
- plasma membrane Source: BHF-UCL
Other locations
- cytoplasm Source: GO_Central
- intracellular membrane-bounded organelle Source: HPA
- membrane Source: UniProtKB
Keywords - Cellular componenti
Cell membrane, Cytoplasm, Endosome, MembranePathology & Biotechi
Mutagenesis
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Mutagenesisi | 49 | R → A: Inhibits targeting to endosomes. 1 Publication | 1 | |
Mutagenesisi | 50 | Y → A: Inhibits targeting to endosomes. 1 Publication | 1 |
Organism-specific databases
DisGeNETi | 11188 |
OpenTargetsi | ENSG00000010322 |
PharmGKBi | PA31635 |
Miscellaneous databases
Pharosi | Q9Y2I1, Tclin |
Chemistry databases
ChEMBLi | CHEMBL3923 |
DrugBanki | DB08838, Agmatine DB09242, Moxonidine DB00697, Tizanidine |
DrugCentrali | Q9Y2I1 |
Genetic variation databases
BioMutai | NISCH |
DMDMi | 296439287 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Initiator methioninei | RemovedCombined sources | |||
ChainiPRO_0000348265 | 2 – 1504 | NischarinAdd BLAST | 1503 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 2 | N-acetylalanineCombined sources | 1 | |
Modified residuei | 541 | PhosphoserineBy similarity | 1 | |
Modified residuei | 543 | PhosphoserineBy similarity | 1 | |
Modified residuei | 546 | PhosphoserineBy similarity | 1 | |
Modified residuei | 1022 | PhosphoserineCombined sources | 1 | |
Modified residuei | 1282 | PhosphothreonineBy similarity | 1 | |
Modified residuei | 1284 | PhosphoserineCombined sources | 1 |
Keywords - PTMi
Acetylation, PhosphoproteinProteomic databases
EPDi | Q9Y2I1 |
jPOSTi | Q9Y2I1 |
MassIVEi | Q9Y2I1 |
MaxQBi | Q9Y2I1 |
PaxDbi | Q9Y2I1 |
PeptideAtlasi | Q9Y2I1 |
PRIDEi | Q9Y2I1 |
ProteomicsDBi | 85789 [Q9Y2I1-1] 85790 [Q9Y2I1-2] 85791 [Q9Y2I1-3] 85792 [Q9Y2I1-4] |
PTM databases
iPTMneti | Q9Y2I1 |
PhosphoSitePlusi | Q9Y2I1 |
Expressioni
Tissue specificityi
Gene expression databases
Bgeei | ENSG00000010322, Expressed in right hemisphere of cerebellum and 241 other tissues |
ExpressionAtlasi | Q9Y2I1, baseline and differential |
Genevisiblei | Q9Y2I1, HS |
Organism-specific databases
HPAi | ENSG00000010322, Low tissue specificity |
Interactioni
Subunit structurei
Homooligomer.
Interacts with GRB2.
Interacts with PIK3R1; probably associates with the PI3-kinase complex.
Interacts with IRS4.
Found in a complex with ITGA5 and PAK1.
Found in a complex with LIMK1 and PAK1.
Interacts with ITGA5 (via cytoplasmic domain); this interaction is direct.
Interacts with PAK1 (via kinase domain); this interaction is direct and is increased upon activation of PAK1 (By similarity).
Interacts with LIMK1 (via PDZ and kinase domain); this interaction is direct (By similarity).
Interacts with LIMK2; this interaction depends on LIMK2 activity (By similarity).
Interacts with RAC1 (activated state) (By similarity).
Interacts with STK11; this interaction may increase STK11 activity.
By similarity3 PublicationsBinary interactionsi
Q9Y2I1
GO - Molecular functioni
- identical protein binding Source: IntAct
- integrin binding Source: Ensembl
- protein kinase binding Source: GO_Central
Protein-protein interaction databases
BioGRIDi | 116358, 107 interactors |
IntActi | Q9Y2I1, 40 interactors |
MINTi | Q9Y2I1 |
STRINGi | 9606.ENSP00000339958 |
Chemistry databases
BindingDBi | Q9Y2I1 |
Miscellaneous databases
RNActi | Q9Y2I1, protein |
Structurei
Secondary structure
3D structure databases
SMRi | Q9Y2I1 |
ModBasei | Search... |
PDBe-KBi | Search... |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 11 – 121 | PXPROSITE-ProRule annotationAdd BLAST | 111 | |
Repeati | 288 – 309 | LRR 1Add BLAST | 22 | |
Repeati | 311 – 332 | LRR 2Add BLAST | 22 | |
Repeati | 333 – 354 | LRR 3Add BLAST | 22 | |
Repeati | 356 – 377 | LRR 4Add BLAST | 22 | |
Repeati | 378 – 399 | LRR 5Add BLAST | 22 | |
Repeati | 403 – 424 | LRR 6Add BLAST | 22 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 2 – 133 | Necessary for binding to phosphoinositide-3-P; not sufficient for targeting to endosomesAdd BLAST | 132 | |
Regioni | 120 – 695 | Necessary for homooligomerization and targeting to endosomesAdd BLAST | 576 | |
Regioni | 245 – 869 | Interaction with PAK1By similarityAdd BLAST | 625 | |
Regioni | 463 – 501 | DisorderedSequence analysisAdd BLAST | 39 | |
Regioni | 524 – 547 | DisorderedSequence analysisAdd BLAST | 24 | |
Regioni | 554 – 573 | DisorderedSequence analysisAdd BLAST | 20 | |
Regioni | 628 – 687 | DisorderedSequence analysisAdd BLAST | 60 | |
Regioni | 660 – 869 | Interaction with LIMKBy similarityAdd BLAST | 210 | |
Regioni | 709 – 807 | Interaction with ITGA5By similarityAdd BLAST | 99 | |
Regioni | 1016 – 1104 | DisorderedSequence analysisAdd BLAST | 89 |
Coiled coil
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Coiled coili | 634 – 695 | Sequence analysisAdd BLAST | 62 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 463 – 477 | Basic and acidic residuesSequence analysisAdd BLAST | 15 | |
Compositional biasi | 483 – 501 | Polar residuesSequence analysisAdd BLAST | 19 | |
Compositional biasi | 633 – 651 | Acidic residuesSequence analysisAdd BLAST | 19 | |
Compositional biasi | 661 – 687 | Acidic residuesSequence analysisAdd BLAST | 27 |
Domaini
Keywords - Domaini
Coiled coil, Leucine-rich repeat, RepeatPhylogenomic databases
eggNOGi | KOG1259, Eukaryota |
GeneTreei | ENSGT00940000156494 |
HOGENOMi | CLU_252294_0_0_1 |
InParanoidi | Q9Y2I1 |
OMAi | PIDKDFY |
OrthoDBi | 320361at2759 |
PhylomeDBi | Q9Y2I1 |
TreeFami | TF320547 |
Family and domain databases
CDDi | cd06875, PX_IRAS, 1 hit |
Gene3Di | 3.30.1520.10, 1 hit 3.80.10.10, 2 hits |
InterProi | View protein in InterPro IPR001611, Leu-rich_rpt IPR032675, LRR_dom_sf IPR037904, Nischarin_PX IPR001683, PX_dom IPR036871, PX_dom_sf |
Pfami | View protein in Pfam PF00787, PX, 1 hit |
SMARTi | View protein in SMART SM00312, PX, 1 hit |
SUPFAMi | SSF64268, SSF64268, 1 hit |
PROSITEi | View protein in PROSITE PS51450, LRR, 6 hits PS50195, PX, 1 hit |
s (4+)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry describes 4 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 4 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MATARTFGPE REAEPAKEAR VVGSELVDTY TVYIIQVTDG SHEWTVKHRY
60 70 80 90 100
SDFHDLHEKL VAERKIDKNL LPPKKIIGKN SRSLVEKREK DLEVYLQKLL
110 120 130 140 150
AAFPGVTPRV LAHFLHFHFY EINGITAALA EELFEKGEQL LGAGEVFAIG
160 170 180 190 200
PLQLYAVTEQ LQQGKPTCAS GDAKTDLGHI LDFTCRLKYL KVSGTEGPFG
210 220 230 240 250
TSNIQEQLLP FDLSIFKSLH QVEISHCDAK HIRGLVASKP TLATLSVRFS
260 270 280 290 300
ATSMKEVLVP EASEFDEWEP EGTTLEGPVT AVIPTWQALT TLDLSHNSVS
310 320 330 340 350
EIDESVKLIP KIEFLDLSHN GLLVVDNLQH LYNLVHLDLS YNKLSSLEGL
360 370 380 390 400
HTKLGNIKTL NLAGNLLESL SGLHKLYSLV NLDLRDNRIE QMEEVRSIGS
410 420 430 440 450
LPCLEHVSLL NNPLSIIPDY RTKVLAQFGE RASEVCLDDT VTTEKELDTV
460 470 480 490 500
EVLKAIQKAK EVKSKLSNPE KKGGEDSRLS AAPCIRPSSS PPTVAPASAS
510 520 530 540 550
LPQPILSNQG IMFVQEEALA SSLSSTDSLT PEHQPIAQGC SDSLESIPAG
560 570 580 590 600
QAASDDLRDV PGAVGGASPE HAEPEVQVVP GSGQIIFLPF TCIGYTATNQ
610 620 630 640 650
DFIQRLSTLI RQAIERQLPA WIEAANQREE GQGEQGEEED EEEEEEEDVA
660 670 680 690 700
ENRYFEMGPP DVEEEEGGGQ GEEEEEEEED EEAEEERLAL EWALGADEDF
710 720 730 740 750
LLEHIRILKV LWCFLIHVQG SIRQFAACLV LTDFGIAVFE IPHQESRGSS
760 770 780 790 800
QHILSSLRFV FCFPHGDLTE FGFLMPELCL VLKVRHSENT LFIISDAANL
810 820 830 840 850
HEFHADLRSC FAPQHMAMLC SPILYGSHTS LQEFLRQLLT FYKVAGGCQE
860 870 880 890 900
RSQGCFPVYL VYSDKRMVQT AAGDYSGNIE WASCTLCSAV RRSCCAPSEA
910 920 930 940 950
VKSAAIPYWL LLTPQHLNVI KADFNPMPNR GTHNCRNRNS FKLSRVPLST
960 970 980 990 1000
VLLDPTRSCT QPRGAFADGH VLELLVGYRF VTAIFVLPHE KFHFLRVYNQ
1010 1020 1030 1040 1050
LRASLQDLKT VVIAKTPGTG GSPQGSFADG QPAERRASND QRPQEVPAEA
1060 1070 1080 1090 1100
LAPAPAEVPA PAPAAASASG PAKTPAPAEA STSALVPEET PVEAPAPPPA
1110 1120 1130 1140 1150
EAPAQYPSEH LIQATSEENQ IPSHLPACPS LRHVASLRGS AIIELFHSSI
1160 1170 1180 1190 1200
AEVENEELRH LMWSSVVFYQ TPGLEVTACV LLSTKAVYFV LHDGLRRYFS
1210 1220 1230 1240 1250
EPLQDFWHQK NTDYNNSPFH ISQCFVLKLS DLQSVNVGLF DQHFRLTGST
1260 1270 1280 1290 1300
PMQVVTCLTR DSYLTHCFLQ HLMVVLSSLE RTPSPEPVDK DFYSEFGNKT
1310 1320 1330 1340 1350
TGKMENYELI HSSRVKFTYP SEEEIGDLTF TVAQKMAEPE KAPALSILLY
1360 1370 1380 1390 1400
VQAFQVGMPP PGCCRGPLRP KTLLLTSSEI FLLDEDCVHY PLPEFAKEPP
1410 1420 1430 1440 1450
QRDRYRLDDG RRVRDLDRVL MGYQTYPQAL TLVFDDVQGH DLMGSVTLDH
1460 1470 1480 1490 1500
FGEVPGGPAR ASQGREVQWQ VFVPSAESRE KLISLLARQW EALCGRELPV
ELTG
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketC9J715 | C9J715_HUMAN | Nischarin | NISCH | 583 | Annotation score: |
Sequence cautioni
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 927 | M → I in AAH56900 (PubMed:15489334).Curated | 1 | |
Sequence conflicti | 1023 | P → A in BAA76819 (PubMed:10231032).Curated | 1 | |
Sequence conflicti | 1123 | S → P in AAH38102 (PubMed:15489334).Curated | 1 | |
Sequence conflicti | 1382 | L → F in AAH54494 (PubMed:15489334).Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_046130 | 299 | V → I6 PublicationsCorresponds to variant dbSNP:rs9856575Ensembl. | 1 | |
Natural variantiVAR_046131 | 1056 | A → V7 PublicationsCorresponds to variant dbSNP:rs887515Ensembl. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_035131 | 1 – 511 | Missing in isoform 2. 1 PublicationAdd BLAST | 511 | |
Alternative sequenceiVSP_035132 | 511 – 583 | IMFVQ…VPGSG → NRVCTLLLVEPHSPAWAPWL GWGWGRGASTCFQQGTQGGG QCLLQAGPRGGTHGRGAWPD ASCCLLGEDSQLL in isoform 3. 1 PublicationAdd BLAST | 73 | |
Alternative sequenceiVSP_035133 | 512 – 515 | MFVQ → LGDE in isoform 4. 1 Publication | 4 | |
Alternative sequenceiVSP_035134 | 516 – 1504 | Missing in isoform 4. 1 PublicationAdd BLAST | 989 | |
Alternative sequenceiVSP_035135 | 584 – 1504 | Missing in isoform 3. 1 PublicationAdd BLAST | 921 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF082516 mRNA Translation: AAC33104.1 AB023192 mRNA Translation: BAA76819.1 Different initiation. AK291398 mRNA Translation: BAF84087.1 AL117432 mRNA Translation: CAB55920.1 AC006208 Genomic DNA No translation available. CH471055 Genomic DNA Translation: EAW65229.1 BC038102 mRNA Translation: AAH38102.1 BC054494 mRNA Translation: AAH54494.1 BC056900 mRNA Translation: AAH56900.1 AF058290 mRNA Translation: AAC33321.1 |
CCDSi | CCDS33767.1 [Q9Y2I1-1] CCDS63651.1 [Q9Y2I1-4] CCDS63652.1 [Q9Y2I1-3] |
PIRi | T17230 |
RefSeqi | NP_001263222.1, NM_001276293.1 NP_001263223.1, NM_001276294.1 [Q9Y2I1-4] NP_009115.2, NM_007184.3 [Q9Y2I1-1] |
Genome annotation databases
Ensembli | ENST00000345716; ENSP00000339958; ENSG00000010322 ENST00000420808; ENSP00000392484; ENSG00000010322 [Q9Y2I1-4] ENST00000479054; ENSP00000418232; ENSG00000010322 |
GeneIDi | 11188 |
KEGGi | hsa:11188 |
MANE-Selecti | ENST00000345716.9; ENSP00000339958.4; NM_007184.4; NP_009115.3 |
UCSCi | uc003ded.5, human [Q9Y2I1-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF082516 mRNA Translation: AAC33104.1 AB023192 mRNA Translation: BAA76819.1 Different initiation. AK291398 mRNA Translation: BAF84087.1 AL117432 mRNA Translation: CAB55920.1 AC006208 Genomic DNA No translation available. CH471055 Genomic DNA Translation: EAW65229.1 BC038102 mRNA Translation: AAH38102.1 BC054494 mRNA Translation: AAH54494.1 BC056900 mRNA Translation: AAH56900.1 AF058290 mRNA Translation: AAC33321.1 |
CCDSi | CCDS33767.1 [Q9Y2I1-1] CCDS63651.1 [Q9Y2I1-4] CCDS63652.1 [Q9Y2I1-3] |
PIRi | T17230 |
RefSeqi | NP_001263222.1, NM_001276293.1 NP_001263223.1, NM_001276294.1 [Q9Y2I1-4] NP_009115.2, NM_007184.3 [Q9Y2I1-1] |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
3P0C | X-ray | 2.27 | A/B | 18-124 | [»] | |
SMRi | Q9Y2I1 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 116358, 107 interactors |
IntActi | Q9Y2I1, 40 interactors |
MINTi | Q9Y2I1 |
STRINGi | 9606.ENSP00000339958 |
Chemistry databases
BindingDBi | Q9Y2I1 |
ChEMBLi | CHEMBL3923 |
DrugBanki | DB08838, Agmatine DB09242, Moxonidine DB00697, Tizanidine |
DrugCentrali | Q9Y2I1 |
PTM databases
iPTMneti | Q9Y2I1 |
PhosphoSitePlusi | Q9Y2I1 |
Genetic variation databases
BioMutai | NISCH |
DMDMi | 296439287 |
Proteomic databases
EPDi | Q9Y2I1 |
jPOSTi | Q9Y2I1 |
MassIVEi | Q9Y2I1 |
MaxQBi | Q9Y2I1 |
PaxDbi | Q9Y2I1 |
PeptideAtlasi | Q9Y2I1 |
PRIDEi | Q9Y2I1 |
ProteomicsDBi | 85789 [Q9Y2I1-1] 85790 [Q9Y2I1-2] 85791 [Q9Y2I1-3] 85792 [Q9Y2I1-4] |
Protocols and materials databases
Antibodypediai | 14512, 107 antibodies from 25 providers |
DNASUi | 11188 |
Genome annotation databases
Ensembli | ENST00000345716; ENSP00000339958; ENSG00000010322 ENST00000420808; ENSP00000392484; ENSG00000010322 [Q9Y2I1-4] ENST00000479054; ENSP00000418232; ENSG00000010322 |
GeneIDi | 11188 |
KEGGi | hsa:11188 |
MANE-Selecti | ENST00000345716.9; ENSP00000339958.4; NM_007184.4; NP_009115.3 |
UCSCi | uc003ded.5, human [Q9Y2I1-1] |
Organism-specific databases
CTDi | 11188 |
DisGeNETi | 11188 |
GeneCardsi | NISCH |
HGNCi | HGNC:18006, NISCH |
HPAi | ENSG00000010322, Low tissue specificity |
MIMi | 615507, gene |
neXtProti | NX_Q9Y2I1 |
OpenTargetsi | ENSG00000010322 |
PharmGKBi | PA31635 |
VEuPathDBi | HostDB:ENSG00000010322 |
HUGEi | Search... |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG1259, Eukaryota |
GeneTreei | ENSGT00940000156494 |
HOGENOMi | CLU_252294_0_0_1 |
InParanoidi | Q9Y2I1 |
OMAi | PIDKDFY |
OrthoDBi | 320361at2759 |
PhylomeDBi | Q9Y2I1 |
TreeFami | TF320547 |
Enzyme and pathway databases
PathwayCommonsi | Q9Y2I1 |
Reactomei | R-HSA-9013149, RAC1 GTPase cycle R-HSA-9696264, RND3 GTPase cycle R-HSA-9696270, RND2 GTPase cycle |
SignaLinki | Q9Y2I1 |
Miscellaneous databases
BioGRID-ORCSi | 11188, 59 hits in 1054 CRISPR screens |
ChiTaRSi | NISCH, human |
GeneWikii | NISCH |
GenomeRNAii | 11188 |
Pharosi | Q9Y2I1, Tclin |
PROi | PR:Q9Y2I1 |
RNActi | Q9Y2I1, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000010322, Expressed in right hemisphere of cerebellum and 241 other tissues |
ExpressionAtlasi | Q9Y2I1, baseline and differential |
Genevisiblei | Q9Y2I1, HS |
Family and domain databases
CDDi | cd06875, PX_IRAS, 1 hit |
Gene3Di | 3.30.1520.10, 1 hit 3.80.10.10, 2 hits |
InterProi | View protein in InterPro IPR001611, Leu-rich_rpt IPR032675, LRR_dom_sf IPR037904, Nischarin_PX IPR001683, PX_dom IPR036871, PX_dom_sf |
Pfami | View protein in Pfam PF00787, PX, 1 hit |
SMARTi | View protein in SMART SM00312, PX, 1 hit |
SUPFAMi | SSF64268, SSF64268, 1 hit |
PROSITEi | View protein in PROSITE PS51450, LRR, 6 hits PS50195, PX, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | NISCH_HUMAN | |
Accessioni | Q9Y2I1Primary (citable) accession number: Q9Y2I1 Secondary accession number(s): C9J245 Q9UFW3 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | September 2, 2008 |
Last sequence update: | May 18, 2010 | |
Last modified: | February 23, 2022 | |
This is version 156 of the entry and version 3 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- UniProtKB entry view manual
User manual for the UniProtKB entry view - Human chromosome 3
Human chromosome 3: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references