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UniProtKB - Q9Y2I1 (NISCH_HUMAN)

Protein

Nischarin

Gene

NISCH

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Acts either as the functional imidazoline-1 receptor (I1R) candidate or as a membrane-associated mediator of the I1R signaling. Binds numerous imidazoline ligands that induces initiation of cell-signaling cascades triggering to cell survival, growth and migration. Its activation by the agonist rilmenidine induces an increase in phosphorylation of mitogen-activated protein kinases MAPK1 and MAPK3 in rostral ventrolateral medulla (RVLM) neurons that exhibited rilmenidine-evoked hypotension (By similarity). Blocking its activation with efaroxan abolished rilmenidine-induced mitogen-activated protein kinase phosphorylation in RVLM neurons (By similarity). Acts as a modulator of Rac-regulated signal transduction pathways (By similarity). Suppresses Rac1-stimulated cell migration by interacting with PAK1 and inhibiting its kinase activity (By similarity). Also blocks Pak-independent Rac signaling by interacting with RAC1 and inhibiting Rac1-stimulated NF-kB response element and cyclin D1 promoter activation (By similarity). Inhibits also LIMK1 kinase activity by reducing LIMK1 'Tyr-508' phosphorylation (By similarity). Inhibits Rac-induced cell migration and invasion in breast and colon epithelial cells (By similarity). Inhibits lamellipodia formation, when overexpressed (By similarity). Plays a role in protection against apoptosis. Involved in association with IRS4 in the enhancement of insulin activation of MAPK1 and MAPK3. When overexpressed, induces a redistribution of cell surface ITGA5 integrin to intracellular endosomal structures.By similarity5 Publications

GO - Molecular functioni

  • identical protein binding Source: IntAct
  • integrin binding Source: Ensembl
  • phosphatidylinositol binding Source: InterPro
View the complete GO annotation on QuickGO ...

GO - Biological processi

View the complete GO annotation on QuickGO ...

Keywordsi

Molecular functionReceptor
Biological processApoptosis

Enzyme and pathway databases

SignaLinkiQ9Y2I1

Names & Taxonomyi

Protein namesi
Recommended name:
Nischarin
Alternative name(s):
Imidazoline receptor 1
Short name:
I-1
Short name:
IR1
Imidazoline receptor antisera-selected protein
Short name:
hIRAS
Imidazoline-1 receptor
Short name:
I1R
Imidazoline-1 receptor candidate protein
Short name:
I-1 receptor candidate protein
Short name:
I1R candidate protein
Gene namesi
Name:NISCH
Synonyms:IRAS, KIAA0975
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
Proteomesi
  • UP000005640 Componenti: Chromosome 3

Organism-specific databases

EuPathDBiHostDB:ENSG00000010322.15
HGNCiHGNC:18006 NISCH
MIMi615507 gene
neXtProtiNX_Q9Y2I1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell membrane, Cytoplasm, Endosome, Membrane

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi49R → A: Inhibits targeting to endosomes. 1 Publication1
Mutagenesisi50Y → A: Inhibits targeting to endosomes. 1 Publication1

Organism-specific databases

DisGeNETi11188
OpenTargetsiENSG00000010322
PharmGKBiPA31635

Chemistry databases

ChEMBLiCHEMBL3923
DrugBankiDB08838 Agmatine
DB09242 Moxonidine
DB00697 Tizanidine

Polymorphism and mutation databases

BioMutaiNISCH
DMDMi296439287

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedCombined sources
ChainiPRO_00003482652 – 1504NischarinAdd BLAST1503

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineCombined sources1
Modified residuei541PhosphoserineBy similarity1
Modified residuei543PhosphoserineBy similarity1
Modified residuei546PhosphoserineBy similarity1
Modified residuei1022PhosphoserineCombined sources1
Modified residuei1282PhosphothreonineBy similarity1
Modified residuei1284PhosphoserineCombined sources1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiQ9Y2I1
PaxDbiQ9Y2I1
PeptideAtlasiQ9Y2I1
PRIDEiQ9Y2I1
ProteomicsDBi85789
85790 [Q9Y2I1-2]
85791 [Q9Y2I1-3]
85792 [Q9Y2I1-4]

PTM databases

iPTMnetiQ9Y2I1
PhosphoSitePlusiQ9Y2I1

Expressioni

Tissue specificityi

Isoform 1, isoform 3 and isoform 4 are expressed in brain. Isoform 1 is expressed in endocrine tissues.2 Publications

Gene expression databases

BgeeiENSG00000010322 Expressed in 228 organ(s), highest expression level in right hemisphere of cerebellum
CleanExiHS_NISCH
ExpressionAtlasiQ9Y2I1 baseline and differential
GenevisibleiQ9Y2I1 HS

Organism-specific databases

HPAiHPA023189

Interactioni

Subunit structurei

Homooligomer. Interacts with GRB2. Interacts with PIK3R1; probably associates with the PI3-kinase complex. Interacts with IRS4. Found in a complex with ITGA5 and PAK1. Found in a complex with LIMK1 and PAK1. Interacts with ITGA5 (via cytoplasmic domain); this interaction is direct. Interacts with PAK1 (via kinase domain); this interaction is direct and is increased upon activation of PAK1 (By similarity). Interacts with LIMK1 (via PDZ and kinase domain); this interaction is direct (By similarity). Interacts with LIMK2; this interaction depends on LIMK2 activity (By similarity). Interacts with RAC1 (activated state) (By similarity). Interacts with STK11; this interaction may increase STK11 activity.By similarity3 Publications

Binary interactionsi

GO - Molecular functioni

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGridi116358, 31 interactors
IntActiQ9Y2I1, 25 interactors
MINTiQ9Y2I1
STRINGi9606.ENSP00000339958

Chemistry databases

BindingDBiQ9Y2I1

Structurei

Secondary structure

11504
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliQ9Y2I1
SMRiQ9Y2I1
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini11 – 121PXPROSITE-ProRule annotationAdd BLAST111
Repeati288 – 309LRR 1Add BLAST22
Repeati311 – 332LRR 2Add BLAST22
Repeati333 – 354LRR 3Add BLAST22
Repeati356 – 377LRR 4Add BLAST22
Repeati378 – 399LRR 5Add BLAST22
Repeati403 – 424LRR 6Add BLAST22

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni2 – 133Necessary for binding to phosphoinositide-3-P; not sufficient for targeting to endosomesAdd BLAST132
Regioni120 – 695Necessary for homooligomerization and targeting to endosomesAdd BLAST576
Regioni245 – 869Interaction with PAK1By similarityAdd BLAST625
Regioni660 – 869Interaction with LIMKBy similarityAdd BLAST210
Regioni709 – 807Interaction with ITGA5By similarityAdd BLAST99

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili634 – 695Sequence analysisAdd BLAST62

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi629 – 691Glu-richAdd BLAST63
Compositional biasi1048 – 1104Ala/Pro-richAdd BLAST57

Domaini

Both the presence of the PX domain and the coiled coil region are necessary for its endosomal targeting.

Keywords - Domaini

Coiled coil, Leucine-rich repeat, Repeat

Phylogenomic databases

eggNOGiENOG410IEQP Eukaryota
ENOG410XQUS LUCA
GeneTreeiENSGT00530000063625
HOVERGENiHBG108189
InParanoidiQ9Y2I1
OMAiGKMENYE
OrthoDBiEOG091G0707
PhylomeDBiQ9Y2I1
TreeFamiTF320547

Family and domain databases

CDDicd06875 PX_IRAS, 1 hit
Gene3Di3.30.1520.10, 1 hit
3.80.10.10, 2 hits
InterProiView protein in InterPro
IPR001611 Leu-rich_rpt
IPR032675 LRR_dom_sf
IPR037904 Nischarin_PX
IPR001683 Phox
IPR036871 PX_dom_sf
PfamiView protein in Pfam
PF00787 PX, 1 hit
SMARTiView protein in SMART
SM00312 PX, 1 hit
SUPFAMiSSF64268 SSF64268, 1 hit
PROSITEiView protein in PROSITE
PS51450 LRR, 6 hits
PS50195 PX, 1 hit

Sequences (4+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 4 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 4 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform 1 (identifier: Q9Y2I1-1) [UniParc]FASTAAdd to basket
Also known as: IRAS-1, IRAS-M

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MATARTFGPE REAEPAKEAR VVGSELVDTY TVYIIQVTDG SHEWTVKHRY 
        60         70         80         90        100
SDFHDLHEKL VAERKIDKNL LPPKKIIGKN SRSLVEKREK DLEVYLQKLL 
       110        120        130        140        150
AAFPGVTPRV LAHFLHFHFY EINGITAALA EELFEKGEQL LGAGEVFAIG 
       160        170        180        190        200
PLQLYAVTEQ LQQGKPTCAS GDAKTDLGHI LDFTCRLKYL KVSGTEGPFG 
       210        220        230        240        250
TSNIQEQLLP FDLSIFKSLH QVEISHCDAK HIRGLVASKP TLATLSVRFS 
       260        270        280        290        300
ATSMKEVLVP EASEFDEWEP EGTTLEGPVT AVIPTWQALT TLDLSHNSVS 
       310        320        330        340        350
EIDESVKLIP KIEFLDLSHN GLLVVDNLQH LYNLVHLDLS YNKLSSLEGL 
       360        370        380        390        400
HTKLGNIKTL NLAGNLLESL SGLHKLYSLV NLDLRDNRIE QMEEVRSIGS 
       410        420        430        440        450
LPCLEHVSLL NNPLSIIPDY RTKVLAQFGE RASEVCLDDT VTTEKELDTV 
       460        470        480        490        500
EVLKAIQKAK EVKSKLSNPE KKGGEDSRLS AAPCIRPSSS PPTVAPASAS 
       510        520        530        540        550
LPQPILSNQG IMFVQEEALA SSLSSTDSLT PEHQPIAQGC SDSLESIPAG 
       560        570        580        590        600
QAASDDLRDV PGAVGGASPE HAEPEVQVVP GSGQIIFLPF TCIGYTATNQ 
       610        620        630        640        650
DFIQRLSTLI RQAIERQLPA WIEAANQREE GQGEQGEEED EEEEEEEDVA 
       660        670        680        690        700
ENRYFEMGPP DVEEEEGGGQ GEEEEEEEED EEAEEERLAL EWALGADEDF 
       710        720        730        740        750
LLEHIRILKV LWCFLIHVQG SIRQFAACLV LTDFGIAVFE IPHQESRGSS 
       760        770        780        790        800
QHILSSLRFV FCFPHGDLTE FGFLMPELCL VLKVRHSENT LFIISDAANL 
       810        820        830        840        850
HEFHADLRSC FAPQHMAMLC SPILYGSHTS LQEFLRQLLT FYKVAGGCQE 
       860        870        880        890        900
RSQGCFPVYL VYSDKRMVQT AAGDYSGNIE WASCTLCSAV RRSCCAPSEA 
       910        920        930        940        950
VKSAAIPYWL LLTPQHLNVI KADFNPMPNR GTHNCRNRNS FKLSRVPLST 
       960        970        980        990       1000
VLLDPTRSCT QPRGAFADGH VLELLVGYRF VTAIFVLPHE KFHFLRVYNQ 
      1010       1020       1030       1040       1050
LRASLQDLKT VVIAKTPGTG GSPQGSFADG QPAERRASND QRPQEVPAEA 
      1060       1070       1080       1090       1100
LAPAPAEVPA PAPAAASASG PAKTPAPAEA STSALVPEET PVEAPAPPPA 
      1110       1120       1130       1140       1150
EAPAQYPSEH LIQATSEENQ IPSHLPACPS LRHVASLRGS AIIELFHSSI 
      1160       1170       1180       1190       1200
AEVENEELRH LMWSSVVFYQ TPGLEVTACV LLSTKAVYFV LHDGLRRYFS 
      1210       1220       1230       1240       1250
EPLQDFWHQK NTDYNNSPFH ISQCFVLKLS DLQSVNVGLF DQHFRLTGST 
      1260       1270       1280       1290       1300
PMQVVTCLTR DSYLTHCFLQ HLMVVLSSLE RTPSPEPVDK DFYSEFGNKT 
      1310       1320       1330       1340       1350
TGKMENYELI HSSRVKFTYP SEEEIGDLTF TVAQKMAEPE KAPALSILLY 
      1360       1370       1380       1390       1400
VQAFQVGMPP PGCCRGPLRP KTLLLTSSEI FLLDEDCVHY PLPEFAKEPP 
      1410       1420       1430       1440       1450
QRDRYRLDDG RRVRDLDRVL MGYQTYPQAL TLVFDDVQGH DLMGSVTLDH 
      1460       1470       1480       1490       1500
FGEVPGGPAR ASQGREVQWQ VFVPSAESRE KLISLLARQW EALCGRELPV 

ELTG
Length:1,504
Mass (Da):166,629
Last modified:May 18, 2010 - v3
Checksum:i7761C7DA1FDC4E53
GO
Isoform 2 (identifier: Q9Y2I1-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-511: Missing.

Show »
Length:993
Mass (Da):110,194
Checksum:iE0415818937AA523
GO
Isoform 3 (identifier: Q9Y2I1-3) [UniParc]FASTAAdd to basket
Also known as: IRAS-L

The sequence of this isoform differs from the canonical sequence as follows:
     511-583: IMFVQEEALA...PEVQVVPGSG → NRVCTLLLVE...CLLGEDSQLL
     584-1504: Missing.

Show »
Length:583
Mass (Da):63,997
Checksum:i83CED19440961191
GO
Isoform 4 (identifier: Q9Y2I1-4) [UniParc]FASTAAdd to basket
Also known as: IRAS-S

The sequence of this isoform differs from the canonical sequence as follows:
     512-515: MFVQ → LGDE
     516-1504: Missing.

Show »
Length:515
Mass (Da):56,867
Checksum:iB623BE4D42BBA51C
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
C9J715C9J715_HUMAN
Nischarin
NISCH
583Annotation score:

Sequence cautioni

The sequence BAA76819 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti927M → I in AAH56900 (PubMed:15489334).Curated1
Sequence conflicti1023P → A in BAA76819 (PubMed:10231032).Curated1
Sequence conflicti1123S → P in AAH38102 (PubMed:15489334).Curated1
Sequence conflicti1382L → F in AAH54494 (PubMed:15489334).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_046130299V → I6 PublicationsCorresponds to variant dbSNP:rs9856575Ensembl.1
Natural variantiVAR_0461311056A → V7 PublicationsCorresponds to variant dbSNP:rs887515Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0351311 – 511Missing in isoform 2. 1 PublicationAdd BLAST511
Alternative sequenceiVSP_035132511 – 583IMFVQ…VPGSG → NRVCTLLLVEPHSPAWAPWL GWGWGRGASTCFQQGTQGGG QCLLQAGPRGGTHGRGAWPD ASCCLLGEDSQLL in isoform 3. 1 PublicationAdd BLAST73
Alternative sequenceiVSP_035133512 – 515MFVQ → LGDE in isoform 4. 1 Publication4
Alternative sequenceiVSP_035134516 – 1504Missing in isoform 4. 1 PublicationAdd BLAST989
Alternative sequenceiVSP_035135584 – 1504Missing in isoform 3. 1 PublicationAdd BLAST921

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF082516 mRNA Translation: AAC33104.1
AB023192 mRNA Translation: BAA76819.1 Different initiation.
AK291398 mRNA Translation: BAF84087.1
AL117432 mRNA Translation: CAB55920.1
AC006208 Genomic DNA No translation available.
CH471055 Genomic DNA Translation: EAW65229.1
BC038102 mRNA Translation: AAH38102.1
BC054494 mRNA Translation: AAH54494.1
BC056900 mRNA Translation: AAH56900.1
AF058290 mRNA Translation: AAC33321.1
CCDSiCCDS33767.1 [Q9Y2I1-1]
CCDS63651.1 [Q9Y2I1-4]
CCDS63652.1 [Q9Y2I1-3]
PIRiT17230
RefSeqiNP_001263222.1, NM_001276293.1
NP_001263223.1, NM_001276294.1
NP_009115.2, NM_007184.3
UniGeneiHs.435290

Genome annotation databases

EnsembliENST00000345716; ENSP00000339958; ENSG00000010322 [Q9Y2I1-1]
ENST00000420808; ENSP00000392484; ENSG00000010322 [Q9Y2I1-4]
ENST00000479054; ENSP00000418232; ENSG00000010322 [Q9Y2I1-1]
GeneIDi11188
KEGGihsa:11188
UCSCiuc003ded.5 human [Q9Y2I1-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF082516 mRNA Translation: AAC33104.1
AB023192 mRNA Translation: BAA76819.1 Different initiation.
AK291398 mRNA Translation: BAF84087.1
AL117432 mRNA Translation: CAB55920.1
AC006208 Genomic DNA No translation available.
CH471055 Genomic DNA Translation: EAW65229.1
BC038102 mRNA Translation: AAH38102.1
BC054494 mRNA Translation: AAH54494.1
BC056900 mRNA Translation: AAH56900.1
AF058290 mRNA Translation: AAC33321.1
CCDSiCCDS33767.1 [Q9Y2I1-1]
CCDS63651.1 [Q9Y2I1-4]
CCDS63652.1 [Q9Y2I1-3]
PIRiT17230
RefSeqiNP_001263222.1, NM_001276293.1
NP_001263223.1, NM_001276294.1
NP_009115.2, NM_007184.3
UniGeneiHs.435290

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3P0CX-ray2.27A/B18-124[»]
ProteinModelPortaliQ9Y2I1
SMRiQ9Y2I1
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi116358, 31 interactors
IntActiQ9Y2I1, 25 interactors
MINTiQ9Y2I1
STRINGi9606.ENSP00000339958

Chemistry databases

BindingDBiQ9Y2I1
ChEMBLiCHEMBL3923
DrugBankiDB08838 Agmatine
DB09242 Moxonidine
DB00697 Tizanidine

PTM databases

iPTMnetiQ9Y2I1
PhosphoSitePlusiQ9Y2I1

Polymorphism and mutation databases

BioMutaiNISCH
DMDMi296439287

Proteomic databases

EPDiQ9Y2I1
PaxDbiQ9Y2I1
PeptideAtlasiQ9Y2I1
PRIDEiQ9Y2I1
ProteomicsDBi85789
85790 [Q9Y2I1-2]
85791 [Q9Y2I1-3]
85792 [Q9Y2I1-4]

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000345716; ENSP00000339958; ENSG00000010322 [Q9Y2I1-1]
ENST00000420808; ENSP00000392484; ENSG00000010322 [Q9Y2I1-4]
ENST00000479054; ENSP00000418232; ENSG00000010322 [Q9Y2I1-1]
GeneIDi11188
KEGGihsa:11188
UCSCiuc003ded.5 human [Q9Y2I1-1]

Organism-specific databases

CTDi11188
DisGeNETi11188
EuPathDBiHostDB:ENSG00000010322.15
GeneCardsiNISCH
HGNCiHGNC:18006 NISCH
HPAiHPA023189
MIMi615507 gene
neXtProtiNX_Q9Y2I1
OpenTargetsiENSG00000010322
PharmGKBiPA31635
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IEQP Eukaryota
ENOG410XQUS LUCA
GeneTreeiENSGT00530000063625
HOVERGENiHBG108189
InParanoidiQ9Y2I1
OMAiGKMENYE
OrthoDBiEOG091G0707
PhylomeDBiQ9Y2I1
TreeFamiTF320547

Enzyme and pathway databases

SignaLinkiQ9Y2I1

Miscellaneous databases

ChiTaRSiNISCH human
GeneWikiiNISCH
GenomeRNAii11188
PROiPR:Q9Y2I1
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000010322 Expressed in 228 organ(s), highest expression level in right hemisphere of cerebellum
CleanExiHS_NISCH
ExpressionAtlasiQ9Y2I1 baseline and differential
GenevisibleiQ9Y2I1 HS

Family and domain databases

CDDicd06875 PX_IRAS, 1 hit
Gene3Di3.30.1520.10, 1 hit
3.80.10.10, 2 hits
InterProiView protein in InterPro
IPR001611 Leu-rich_rpt
IPR032675 LRR_dom_sf
IPR037904 Nischarin_PX
IPR001683 Phox
IPR036871 PX_dom_sf
PfamiView protein in Pfam
PF00787 PX, 1 hit
SMARTiView protein in SMART
SM00312 PX, 1 hit
SUPFAMiSSF64268 SSF64268, 1 hit
PROSITEiView protein in PROSITE
PS51450 LRR, 6 hits
PS50195 PX, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiNISCH_HUMAN
AccessioniPrimary (citable) accession number: Q9Y2I1
Secondary accession number(s): C9J245
, Q6PGP3, Q6PIB4, Q7L8M3, Q7Z2X6, Q9UES6, Q9UEU4, Q9UFW3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 2, 2008
Last sequence update: May 18, 2010
Last modified: September 12, 2018
This is version 135 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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