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Protein

Microtubule-associated serine/threonine-protein kinase 1

Gene

MAST1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Appears to link the dystrophin/utrophin network with microtubule filaments via the syntrophins. Phosphorylation of DMD or UTRN may modulate their affinities for associated proteins (By similarity).By similarity

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the ‘Function’ section provides information relevant to cofactors. A cofactor is any non-protein substance required for a protein to be catalytically active. Some cofactors are inorganic, such as the metal atoms zinc, iron, and copper in various oxidation states. Others, such as most vitamins, are organic.<p><a href='/help/cofactor' target='_top'>More...</a></p>Cofactori

Mg2+By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Function’ section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei403ATPPROSITE-ProRule annotationBy similarity1
<p>This subsection of the ‘Function’ section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei497Proton acceptorPROSITE-ProRule annotationBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Function’ section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi380 – 388ATPPROSITE-ProRule annotationBy similarity9

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionKinase, Serine/threonine-protein kinase, Transferase
LigandATP-binding, Magnesium, Metal-binding, Nucleotide-binding

Enzyme and pathway databases

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...
SignaLinki
Q9Y2H9

SIGNOR Signaling Network Open Resource

More...
SIGNORi
Q9Y2H9

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Microtubule-associated serine/threonine-protein kinase 1 (EC:2.7.11.1)
Alternative name(s):
Syntrophin-associated serine/threonine-protein kinase
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:MAST1Imported
Synonyms:KIAA0973Imported, SAST
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 19

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000105613.9

Human Gene Nomenclature Database

More...
HGNCi
HGNC:19034 MAST1

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
612256 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q9Y2H9

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell membrane, Cytoplasm, Cytoskeleton, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Open Targets

More...
OpenTargetsi
ENSG00000105613

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA134946727

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...
ChEMBLi
CHEMBL1163128

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
MAST1

Domain mapping of disease mutations (DMDM)

More...
DMDMi
60390226

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000863091 – 1570Microtubule-associated serine/threonine-protein kinase 1Add BLAST1570

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei90PhosphoserineBy similarity1
Modified residuei139PhosphoserineBy similarity1
Modified residuei167PhosphoserineBy similarity1
Modified residuei346PhosphoserineBy similarity1
Modified residuei351PhosphothreonineBy similarity1
Modified residuei687PhosphoserineBy similarity1
Modified residuei893PhosphoserineBy similarity1
Modified residuei952PhosphoserineBy similarity1
Modified residuei1413PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q9Y2H9

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q9Y2H9

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q9Y2H9

PeptideAtlas

More...
PeptideAtlasi
Q9Y2H9

PRoteomics IDEntifications database

More...
PRIDEi
Q9Y2H9

ProteomicsDB human proteome resource

More...
ProteomicsDBi
85788

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q9Y2H9

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q9Y2H9

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000105613 Expressed in 107 organ(s), highest expression level in cerebellar hemisphere

CleanEx database of gene expression profiles

More...
CleanExi
HS_MAST1

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q9Y2H9 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q9Y2H9 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA028181
HPA073106

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Part of a low affinity complex that associates with, but is distinct from, the postsynaptic density. Interacts with SNTB2 (By similarity).By similarity

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

WithEntry#Exp.IntActNotes
EGFRP005332EBI-3385920,EBI-297353

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
116632, 40 interactors

Protein interaction database and analysis system

More...
IntActi
Q9Y2H9, 36 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000251472

Chemistry databases

BindingDB database of measured binding affinities

More...
BindingDBi
Q9Y2H9

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

11570
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

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ProteinModelPortali
Q9Y2H9

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q9Y2H9

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...
EvolutionaryTracei
Q9Y2H9

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini374 – 647Protein kinasePROSITE-ProRule annotationAdd BLAST274
Domaini648 – 719AGC-kinase C-terminalAdd BLAST72
Domaini967 – 1055PDZPROSITE-ProRule annotationAdd BLAST89

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG0606 Eukaryota
ENOG410XPWX LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000157700

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000046662

The HOVERGEN Database of Homologous Vertebrate Genes

More...
HOVERGENi
HBG052414

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q9Y2H9

KEGG Orthology (KO)

More...
KOi
K08789

Identification of Orthologs from Complete Genome Data

More...
OMAi
RARHQQM

Database of Orthologous Groups

More...
OrthoDBi
EOG091G00IH

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q9Y2H9

TreeFam database of animal gene trees

More...
TreeFami
TF313149

Family and domain databases

Conserved Domains Database

More...
CDDi
cd05609 STKc_MAST, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.20.1480.20, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR000961 AGC-kinase_C
IPR011009 Kinase-like_dom_sf
IPR015022 MA_Ser/Thr_Kinase_dom
IPR037711 MAST
IPR028777 MAST1
IPR023142 MAST_pre-PK_dom_sf
IPR001478 PDZ
IPR036034 PDZ_sf
IPR000719 Prot_kinase_dom
IPR008271 Ser/Thr_kinase_AS

The PANTHER Classification System

More...
PANTHERi
PTHR24356:SF150 PTHR24356:SF150, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF08926 DUF1908, 1 hit
PF00069 Pkinase, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00228 PDZ, 1 hit
SM00220 S_TKc, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF140482 SSF140482, 1 hit
SSF50156 SSF50156, 1 hit
SSF56112 SSF56112, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51285 AGC_KINASE_CTER, 1 hit
PS50106 PDZ, 1 hit
PS50011 PROTEIN_KINASE_DOM, 1 hit
PS00108 PROTEIN_KINASE_ST, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show allAlign All

Q9Y2H9-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSDSLWTALS NFSMPSFPGG SMFRRTKSCR TSNRKSLILT STSPTLPRPH
60 70 80 90 100
SPLPGHLGSS PLDSPRNFSP NTPAHFSFAS SRRADGRRWS LASLPSSGYG
110 120 130 140 150
TNTPSSTVSS SCSSQERLHQ LPYQPTVDEL HFLSKHFGST ESITDEDGGR
160 170 180 190 200
RSPAVRPRSR SLSPGRSPSS YDNEIVMMNH VYKERFPKAT AQMEEKLRDF
210 220 230 240 250
TRAYEPDSVL PLADGVLSFI HHQIIELARD CLTKSRDGLI TTVYFYELQE
260 270 280 290 300
NLEKLLQDAY ERSESLEVAF VTQLVKKLLI IISRPARLLE CLEFNPEEFY
310 320 330 340 350
HLLEAAEGHA KEGHLVKTDI PRYIIRQLGL TRDPFPDVVH LEEQDSGGSN
360 370 380 390 400
TPEQDDLSEG RSSKAKKPPG ENDFDTIKLI SNGAYGAVYL VRHRDTRQRF
410 420 430 440 450
AMKKINKQNL ILRNQIQQAF VERDILTFAE NPFVVGMFCS FETRRHLCMV
460 470 480 490 500
MEYVEGGDCA TLLKNIGALP VEMARMYFAE TVLALEYLHN YGIVHRDLKP
510 520 530 540 550
DNLLITSMGH IKLTDFGLSK MGLMSLTTNL YEGHIEKDAR EFLDKQVCGT
560 570 580 590 600
PEYIAPEVIL RQGYGKPVDW WAMGIILYEF LVGCVPFFGD TPEELFGQVI
610 620 630 640 650
SDDILWPEGD EALPTEAQLL ISSLLQTNPL VRLGAGGAFE VKQHSFFRDL
660 670 680 690 700
DWTGLLRQKA EFIPHLESED DTSYFDTRSD RYHHVNSYDE DDTTEEEPVE
710 720 730 740 750
IRQFSSCSPR FSKVYSSMEQ LSQHEPKTPV AAAGSSKREP STKGPEEKVA
760 770 780 790 800
GKREGLGGLT LREKTWRGGS PEIKRFSASE ASFLEGEASP PLGARRRFSA
810 820 830 840 850
LLEPSRFSAP QEDEDEARLR RPPRPSSDPA GSLDARAPKE ETQGEGTSSA
860 870 880 890 900
GDSEATDRPR PGDLCPPSKD GDASGPRATN DLVLRRARHQ QMSGDVAVEK
910 920 930 940 950
RPSRTGGKVI KSASATALSV MIPAVDPHGS SPLASPMSPR SLSSNPSSRD
960 970 980 990 1000
SSPSRDYSPA VSGLRSPITI QRSGKKYGFT LRAIRVYMGD TDVYSVHHIV
1010 1020 1030 1040 1050
WHVEEGGPAQ EAGLCAGDLI THVNGEPVHG MVHPEVVELI LKSGNKVAVT
1060 1070 1080 1090 1100
TTPFENTSIR IGPARRSSYK AKMARRNKRP SAKEGQESKK RSSLFRKITK
1110 1120 1130 1140 1150
QSNLLHTSRS LSSLNRSLSS SDSLPGSPTH GLPARSPTHS YRSTPDSAYL
1160 1170 1180 1190 1200
GASSQSSSPA SSTPNSPASS ASHHIRPSTL HGLSPKLHRQ YRSARCKSAG
1210 1220 1230 1240 1250
NIPLSPLAHT PSPTQASPPP LPGHTVGSSH TTQSFPAKLH SSPPVVRPRP
1260 1270 1280 1290 1300
KSAEPPRSPL LKRVQSAEKL GASLSADKKG ALRKHSLEVG HPDFRKDFHG
1310 1320 1330 1340 1350
ELALHSLAES DGETPPVEGL GAPRQVAVRR LGRQESPLSL GADPLLPEGA
1360 1370 1380 1390 1400
SRPPVSSKEK ESPGGAEACT PPRATTPGGR TLERDVGCTR HQSVQTEDGT
1410 1420 1430 1440 1450
GGMARAVAKA ALSPVQEHET GRRSSSGEAG TPLVPIVVEP ARPGAKAVVP
1460 1470 1480 1490 1500
QPLGADSKGL QEPAPLAPSV PEAPRGRERW VLEVVEERTT LSGPRSKPAS
1510 1520 1530 1540 1550
PKLSPEPQTP SLAPAKCSAP SSAVTPVPPA SLLGSGTKPQ VGLTSRCPAE
1560 1570
AVPPAGLTKK GVSSPAPPGP
Length:1,570
Mass (Da):170,677
Last modified:March 1, 2005 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i189D24AE07B62A1E
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
K7EJZ9K7EJZ9_HUMAN
Microtubule-associated serine/threo...
MAST1
433Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
K7EME4K7EME4_HUMAN
Microtubule-associated serine/threo...
MAST1
475Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
K7EJI7K7EJI7_HUMAN
Microtubule-associated serine/threo...
MAST1
133Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAB51171 differs from that shown. Reason: Erroneous gene model prediction.Curated
The sequence AAH27985 differs from that shown. Reason: Erroneous initiation.Curated
The sequence BAA76817 differs from that shown. Reason: Erroneous initiation.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_040768269A → T in a metastatic melanoma sample; somatic mutation. 1 Publication1
Natural variantiVAR_0516441048A → S. Corresponds to variant dbSNP:rs35052801Ensembl.1
Natural variantiVAR_0407691240H → Y in an ovarian serous carcinoma sample; somatic mutation. 1 Publication1
Natural variantiVAR_0407701292P → S1 PublicationCorresponds to variant dbSNP:rs35071862Ensembl.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AB023190 mRNA Translation: BAA76817.1 Different initiation.
AC020934 Genomic DNA No translation available.
AD000092 Genomic DNA Translation: AAB51171.1 Sequence problems.
BC027985 mRNA Translation: AAH27985.2 Different initiation.

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS32921.1

Protein sequence database of the Protein Information Resource

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PIRi
T45070

NCBI Reference Sequences

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RefSeqi
NP_055790.1, NM_014975.2

UniGene gene-oriented nucleotide sequence clusters

More...
UniGenei
Hs.227489

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENST00000251472; ENSP00000251472; ENSG00000105613

Database of genes from NCBI RefSeq genomes

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GeneIDi
22983

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:22983

UCSC genome browser

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UCSCi
uc002mvm.4 human

Keywords - Coding sequence diversityi

Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB023190 mRNA Translation: BAA76817.1 Different initiation.
AC020934 Genomic DNA No translation available.
AD000092 Genomic DNA Translation: AAB51171.1 Sequence problems.
BC027985 mRNA Translation: AAH27985.2 Different initiation.
CCDSiCCDS32921.1
PIRiT45070
RefSeqiNP_055790.1, NM_014975.2
UniGeneiHs.227489

3D structure databases

Select the link destinations:

Protein Data Bank Europe

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PDBei

Protein Data Bank RCSB

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RCSB PDBi

Protein Data Bank Japan

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PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2M9XNMR-A187-287[»]
3PS4X-ray1.85A/B/C/D965-1057[»]
ProteinModelPortaliQ9Y2H9
SMRiQ9Y2H9
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi116632, 40 interactors
IntActiQ9Y2H9, 36 interactors
STRINGi9606.ENSP00000251472

Chemistry databases

BindingDBiQ9Y2H9
ChEMBLiCHEMBL1163128

PTM databases

iPTMnetiQ9Y2H9
PhosphoSitePlusiQ9Y2H9

Polymorphism and mutation databases

BioMutaiMAST1
DMDMi60390226

Proteomic databases

EPDiQ9Y2H9
MaxQBiQ9Y2H9
PaxDbiQ9Y2H9
PeptideAtlasiQ9Y2H9
PRIDEiQ9Y2H9
ProteomicsDBi85788

Protocols and materials databases

The DNASU plasmid repository

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DNASUi
22983
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000251472; ENSP00000251472; ENSG00000105613
GeneIDi22983
KEGGihsa:22983
UCSCiuc002mvm.4 human

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
22983
EuPathDBiHostDB:ENSG00000105613.9

GeneCards: human genes, protein and diseases

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GeneCardsi
MAST1
HGNCiHGNC:19034 MAST1
HPAiHPA028181
HPA073106
MIMi612256 gene
neXtProtiNX_Q9Y2H9
OpenTargetsiENSG00000105613
PharmGKBiPA134946727

Human Unidentified Gene-Encoded large proteins database

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HUGEi
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GenAtlas: human gene database

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GenAtlasi
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Phylogenomic databases

eggNOGiKOG0606 Eukaryota
ENOG410XPWX LUCA
GeneTreeiENSGT00940000157700
HOGENOMiHOG000046662
HOVERGENiHBG052414
InParanoidiQ9Y2H9
KOiK08789
OMAiRARHQQM
OrthoDBiEOG091G00IH
PhylomeDBiQ9Y2H9
TreeFamiTF313149

Enzyme and pathway databases

SignaLinkiQ9Y2H9
SIGNORiQ9Y2H9

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
MAST1 human
EvolutionaryTraceiQ9Y2H9

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
MAST1

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
22983

Protein Ontology

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PROi
PR:Q9Y2H9

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
Search...

Gene expression databases

BgeeiENSG00000105613 Expressed in 107 organ(s), highest expression level in cerebellar hemisphere
CleanExiHS_MAST1
ExpressionAtlasiQ9Y2H9 baseline and differential
GenevisibleiQ9Y2H9 HS

Family and domain databases

CDDicd05609 STKc_MAST, 1 hit
Gene3Di1.20.1480.20, 1 hit
InterProiView protein in InterPro
IPR000961 AGC-kinase_C
IPR011009 Kinase-like_dom_sf
IPR015022 MA_Ser/Thr_Kinase_dom
IPR037711 MAST
IPR028777 MAST1
IPR023142 MAST_pre-PK_dom_sf
IPR001478 PDZ
IPR036034 PDZ_sf
IPR000719 Prot_kinase_dom
IPR008271 Ser/Thr_kinase_AS
PANTHERiPTHR24356:SF150 PTHR24356:SF150, 1 hit
PfamiView protein in Pfam
PF08926 DUF1908, 1 hit
PF00069 Pkinase, 1 hit
SMARTiView protein in SMART
SM00228 PDZ, 1 hit
SM00220 S_TKc, 1 hit
SUPFAMiSSF140482 SSF140482, 1 hit
SSF50156 SSF50156, 1 hit
SSF56112 SSF56112, 1 hit
PROSITEiView protein in PROSITE
PS51285 AGC_KINASE_CTER, 1 hit
PS50106 PDZ, 1 hit
PS50011 PROTEIN_KINASE_DOM, 1 hit
PS00108 PROTEIN_KINASE_ST, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiMAST1_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9Y2H9
Secondary accession number(s): O00114, Q8N6X0
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 1, 2005
Last sequence update: March 1, 2005
Last modified: December 5, 2018
This is version 162 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families
  3. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  4. Human and mouse protein kinases
    Human and mouse protein kinases: classification and index
  5. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  6. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  7. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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