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UniProtKB - Q9Y2H6 (FND3A_HUMAN)

Entry version 166 (18 Sep 2019)
Sequence version 4 (28 Jul 2009)
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Protein

Fibronectin type-III domain-containing protein 3A

Gene

FNDC3A

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Mediates spermatid-Sertoli adhesion during spermatogenesis.By similarity

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Fibronectin type-III domain-containing protein 3A
Alternative name(s):
Human gene expressed in odontoblasts
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:FNDC3A
Synonyms:FNDC3, HUGO, KIAA0970
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 13

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:20296 FNDC3A

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		615794 gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_Q9Y2H6

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei1177 – 1197HelicalSequence analysisAdd BLAST21

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Golgi apparatus, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...DisGeNETi		22862

Open Targets

More...OpenTargetsi		ENSG00000102531

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA128394588

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		Q9Y2H6

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		FNDC3A

Domain mapping of disease mutations (DMDM)

More...DMDMi		254763442

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000873211 – 1198Fibronectin type-III domain-containing protein 3AAdd BLAST1198

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei203PhosphoserineCombined sources1
Modified residuei207PhosphoserineBy similarity1
Modified residuei213PhosphoserineCombined sources1
Modified residuei384N6-acetyllysineCombined sources1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		Q9Y2H6

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		Q9Y2H6

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		Q9Y2H6

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q9Y2H6

PeptideAtlas

More...PeptideAtlasi		Q9Y2H6

PRoteomics IDEntifications database

More...PRIDEi		Q9Y2H6

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		85785 [Q9Y2H6-1]
85786 [Q9Y2H6-2]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q9Y2H6

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q9Y2H6

SwissPalm database of S-palmitoylation events

More...SwissPalmi		Q9Y2H6

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed in the odontoblast and nerves in the dental pulp. Also expressed in trachea and to a lesser extent in the brain, liver, lung and kidney.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000102531 Expressed in 236 organ(s), highest expression level in chorionic villus

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		Q9Y2H6 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q9Y2H6 HS

Organism-specific databases

Human Protein Atlas

More...HPAi		HPA008927
HPA012825

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...BioGridi		116530, 48 interactors

Protein interaction database and analysis system

More...IntActi		Q9Y2H6, 47 interactors

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000441831

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

11198
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q9Y2H6

Database of comparative protein structure models

More...ModBasei		Search...

Protein Data Bank in Europe - Knowledge Base

More...PDBe-KBi		Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...EvolutionaryTracei		Q9Y2H6

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini268 – 369Fibronectin type-III 1PROSITE-ProRule annotationAdd BLAST102
Domaini373 – 465Fibronectin type-III 2PROSITE-ProRule annotationAdd BLAST93
Domaini469 – 562Fibronectin type-III 3PROSITE-ProRule annotationAdd BLAST94
Domaini566 – 660Fibronectin type-III 4PROSITE-ProRule annotationAdd BLAST95
Domaini664 – 757Fibronectin type-III 5PROSITE-ProRule annotationAdd BLAST94
Domaini761 – 851Fibronectin type-III 6PROSITE-ProRule annotationAdd BLAST91
Domaini861 – 950Fibronectin type-III 7PROSITE-ProRule annotationAdd BLAST90
Domaini951 – 1045Fibronectin type-III 8PROSITE-ProRule annotationAdd BLAST95
Domaini1046 – 1151Fibronectin type-III 9PROSITE-ProRule annotationAdd BLAST106

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi68 – 133Pro-richAdd BLAST66

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the FNDC3 family.Curated

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		ENOG410IE8R Eukaryota
ENOG410XNUW LUCA

Ensembl GeneTree

More...GeneTreei		ENSGT00940000159319

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q9Y2H6

Identification of Orthologs from Complete Genome Data

More...OMAi		AYFVAQD

Database of Orthologous Groups

More...OrthoDBi		633003at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q9Y2H6

TreeFam database of animal gene trees

More...TreeFami		TF316401

Family and domain databases

Conserved Domains Database

More...CDDi		cd00063 FN3, 9 hits

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		2.60.40.10, 9 hits

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR003961 FN3_dom
IPR036116 FN3_sf
IPR013783 Ig-like_fold

Pfam protein domain database

More...Pfami		View protein in Pfam
PF00041 fn3, 7 hits

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00060 FN3, 9 hits

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF49265 SSF49265, 6 hits

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS50853 FN3, 9 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative promoter usage. AlignAdd to basket

This entry has 2 described isoforms and 3 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q9Y2H6-1) [UniParc]FASTAAdd to basket
Also known as: HUGO1

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MAEHPPLLDT TQILSSDISL LSAPIVSADG TQQVILVQVN PGEAFTIRRE 
        60         70         80         90        100
DGQFQCITGP AQVPMMSPNG SVPPIYVPPG YAPQVIEDNG VRRVVVVPQA 
       110        120        130        140        150
PEFHPGSHTV LHRSPHPPLP GFIPVPTMMP PPPRHMYSPV TGAGDMTTQY 
       160        170        180        190        200
MPQYQSSQVY GDVDAHSTHG RSNFRDERSS KTYERLQKKL KDRQGTQKDK 
       210        220        230        240        250
MSSPPSSPQK CPSPINEHNG LIKGQIAGGI NTGSAKIKSG KGKGGTQVDT 
       260        270        280        290        300
EIEEKDEETK AFEALLSNIV KPVASDIQAR TVVLTWSPPS SLINGETDES 
       310        320        330        340        350
SVPELYGYEV LISSTGKDGK YKSVYVGEET NITLNDLKPA MDYHAKVQAE 
       360        370        380        390        400
YNSIKGTPSE AEIFTTLSCE PDIPNPPRIA NRTKNSLTLQ WKAPSDNGSK 
       410        420        430        440        450
IQNFVLEWDE GKGNGEFCQC YMGSQKQFKI TKLSPAMGCK FRLSARNDYG 
       460        470        480        490        500
TSGFSEEVLY YTSGCAPSMP ASPVLTKAGI TWLSLQWSKP SGTPSDEGIS 
       510        520        530        540        550
YILEMEEETS GYGFKPKYDG EDLAYTVKNL RRSTKYKFKV IAYNSEGKSN 
       560        570        580        590        600
PSEVVEFTTC PDKPGIPVKP SVKGKIHSHS FKITWDPPKD NGGATINKYV 
       610        620        630        640        650
VEMAEGSNGN KWEMIYSGAT REHLCDRLNP GCFYRLRVYC ISDGGQSAVS 
       660        670        680        690        700
ESLLVQTPAV PPGPCLPPRL QGRPKAKEIQ LRWGPPLVDG GSPISCYSVE 
       710        720        730        740        750
MSPIEKDEPR EVYQGSEVEC TVSSLLPGKT YSFRLRAANK MGFGPFSEKC 
       760        770        780        790        800
DITTAPGPPD QCKPPQVTCR SATCAQVNWE VPLSNGTDVT EYRLEWGGVE 
       810        820        830        840        850
GSMQICYCGP GLSYEIKGLS PATTYYCRVQ ALSVVGAGPF SEVVACVTPP 
       860        870        880        890        900
SVPGIVTCLQ EISDDEIENP HYSPSTCLAI SWEKPCDHGS EILAYSIDFG 
       910        920        930        940        950
DKQSLTVGKV TSYIINNLQP DTTYRIRIQA LNSLGAGPFS HMIKLKTKPL 
       960        970        980        990       1000
PPDPPRLECV AFSHQNLKLK WGEGTPKTLS TDSIQYHLQM EDKNGRFVSL 
      1010       1020       1030       1040       1050
YRGPCHTYKV QRLNESTSYK FCIQACNEAG EGPLSQEYIF TTPKSVPAAL 
      1060       1070       1080       1090       1100
KAPKIEKVND HICEITWECL QPMKGDPVIY SLQVMLGKDS EFKQIYKGPD 
      1110       1120       1130       1140       1150
SSFRYSSLQL NCEYRFRVCA IRQCQDSLGH QDLVGPYSTT VLFISQRTEP 
      1160       1170       1180       1190 
PASTNRDTVE STRTRRALSD EQCAAVILVL FAFFSILIAF IIQYFVIK
Length:1,198
Mass (Da):131,852
Last modified:July 28, 2009 - v4
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i2809E41E89BDD095
GO
Isoform 2 (identifier: Q9Y2H6-2) [UniParc]FASTAAdd to basket
Also known as: HUGO2

The sequence of this isoform differs from the canonical sequence as follows:
     1-56: Missing.
     57-58: IT → MS

Show »
Length:1,142
Mass (Da):125,822
Checksum:i2136F2F51012A73F
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
G5E9X3G5E9X3_HUMAN
Fibronectin type III domain contain...
FNDC3A hCG_1811703
684Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A087X1M6A0A087X1M6_HUMAN
Fibronectin type-III domain-contain...
FNDC3A
326Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H7C507H7C507_HUMAN
Fibronectin type-III domain-contain...
FNDC3A
139Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence BAA76814 differs from that shown. Reason: Erroneous initiation.Curated
The sequence BAD18784 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti53Q → R in CAI45989 (PubMed:17974005).Curated1
Sequence conflicti350E → G in CAE45852 (PubMed:17974005).Curated1
Sequence conflicti501Y → H in CAE45852 (PubMed:17974005).Curated1
Sequence conflicti839P → R in AAH60816 (PubMed:15489334).Curated1
Sequence conflicti839P → R in AAH70072 (PubMed:15489334).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_059655107S → G. Corresponds to variant dbSNP:rs34539036Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0377231 – 56Missing in isoform 2. 4 PublicationsAdd BLAST56
Alternative sequenceiVSP_03772457 – 58IT → MS in isoform 2. 4 Publications2

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AJ749706 mRNA Translation: CAG44602.1
AJ749707 mRNA Translation: CAG44603.1
AB023187 mRNA Translation: BAA76814.2 Different initiation.
AK172814 mRNA Translation: BAD18784.1 Different initiation.
AK302415 mRNA Translation: BAG63723.1
BX640739 mRNA Translation: CAE45852.1
BX648141 mRNA Translation: CAI45989.1
AL161421 Genomic DNA No translation available.
AL359184 Genomic DNA No translation available.
AL137000 Genomic DNA No translation available.
CH471075 Genomic DNA Translation: EAX08804.1
CH471075 Genomic DNA Translation: EAX08806.1
BC060816 mRNA Translation: AAH60816.1
BC070072 mRNA Translation: AAH70072.1
BC132812 mRNA Translation: AAI32813.1
BC136617 mRNA Translation: AAI36618.1
BC144301 mRNA Translation: AAI44302.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS41886.1 [Q9Y2H6-1]
CCDS9413.2 [Q9Y2H6-2]

NCBI Reference Sequences

More...RefSeqi		NP_001073141.1, NM_001079673.1 [Q9Y2H6-1]
NP_001265367.1, NM_001278438.1 [Q9Y2H6-1]
NP_055738.3, NM_014923.4 [Q9Y2H6-2]
XP_011533299.1, XM_011534997.2
XP_016875929.1, XM_017020440.1 [Q9Y2H6-1]
XP_016875930.1, XM_017020441.1
XP_016875931.1, XM_017020442.1

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000398316; ENSP00000381362; ENSG00000102531 [Q9Y2H6-2]
ENST00000492622; ENSP00000417257; ENSG00000102531 [Q9Y2H6-1]
ENST00000541916; ENSP00000441831; ENSG00000102531 [Q9Y2H6-1]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		22862

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:22862

UCSC genome browser

More...UCSCi		uc001vcm.3 human [Q9Y2H6-1]

Keywords - Coding sequence diversityi

Alternative promoter usage, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ749706 mRNA Translation: CAG44602.1
AJ749707 mRNA Translation: CAG44603.1
AB023187 mRNA Translation: BAA76814.2 Different initiation.
AK172814 mRNA Translation: BAD18784.1 Different initiation.
AK302415 mRNA Translation: BAG63723.1
BX640739 mRNA Translation: CAE45852.1
BX648141 mRNA Translation: CAI45989.1
AL161421 Genomic DNA No translation available.
AL359184 Genomic DNA No translation available.
AL137000 Genomic DNA No translation available.
CH471075 Genomic DNA Translation: EAX08804.1
CH471075 Genomic DNA Translation: EAX08806.1
BC060816 mRNA Translation: AAH60816.1
BC070072 mRNA Translation: AAH70072.1
BC132812 mRNA Translation: AAI32813.1
BC136617 mRNA Translation: AAI36618.1
BC144301 mRNA Translation: AAI44302.1
CCDSiCCDS41886.1 [Q9Y2H6-1]
CCDS9413.2 [Q9Y2H6-2]
RefSeqiNP_001073141.1, NM_001079673.1 [Q9Y2H6-1]
NP_001265367.1, NM_001278438.1 [Q9Y2H6-1]
NP_055738.3, NM_014923.4 [Q9Y2H6-2]
XP_011533299.1, XM_011534997.2
XP_016875929.1, XM_017020440.1 [Q9Y2H6-1]
XP_016875930.1, XM_017020441.1
XP_016875931.1, XM_017020442.1

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...PDBei

Protein Data Bank RCSB

More...RCSB PDBi

Protein Data Bank Japan

More...PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1WK0NMR-A256-379[»]
1X3DNMR-A361-465[»]
1X4XNMR-A759-851[»]
1X5XNMR-A467-562[»]
2CRMNMR-A554-660[»]
2CRZNMR-A661-757[»]
SMRiQ9Y2H6
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGridi116530, 48 interactors
IntActiQ9Y2H6, 47 interactors
STRINGi9606.ENSP00000441831

PTM databases

iPTMnetiQ9Y2H6
PhosphoSitePlusiQ9Y2H6
SwissPalmiQ9Y2H6

Polymorphism and mutation databases

BioMutaiFNDC3A
DMDMi254763442

Proteomic databases

EPDiQ9Y2H6
jPOSTiQ9Y2H6
MassIVEiQ9Y2H6
PaxDbiQ9Y2H6
PeptideAtlasiQ9Y2H6
PRIDEiQ9Y2H6
ProteomicsDBi85785 [Q9Y2H6-1]
85786 [Q9Y2H6-2]

Genome annotation databases

EnsembliENST00000398316; ENSP00000381362; ENSG00000102531 [Q9Y2H6-2]
ENST00000492622; ENSP00000417257; ENSG00000102531 [Q9Y2H6-1]
ENST00000541916; ENSP00000441831; ENSG00000102531 [Q9Y2H6-1]
GeneIDi22862
KEGGihsa:22862
UCSCiuc001vcm.3 human [Q9Y2H6-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		22862
DisGeNETi22862

GeneCards: human genes, protein and diseases

More...GeneCardsi		FNDC3A
HGNCiHGNC:20296 FNDC3A
HPAiHPA008927
HPA012825
MIMi615794 gene
neXtProtiNX_Q9Y2H6
OpenTargetsiENSG00000102531
PharmGKBiPA128394588

Human Unidentified Gene-Encoded large proteins database

More...HUGEi		Search...

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiENOG410IE8R Eukaryota
ENOG410XNUW LUCA
GeneTreeiENSGT00940000159319
InParanoidiQ9Y2H6
OMAiAYFVAQD
OrthoDBi633003at2759
PhylomeDBiQ9Y2H6
TreeFamiTF316401

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		FNDC3A human
EvolutionaryTraceiQ9Y2H6

The Gene Wiki collection of pages on human genes and proteins

More...GeneWikii		FNDC3A

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		22862
PharosiQ9Y2H6

Protein Ontology

More...PROi		PR:Q9Y2H6

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000102531 Expressed in 236 organ(s), highest expression level in chorionic villus
ExpressionAtlasiQ9Y2H6 baseline and differential
GenevisibleiQ9Y2H6 HS

Family and domain databases

CDDicd00063 FN3, 9 hits
Gene3Di2.60.40.10, 9 hits
InterProiView protein in InterPro
IPR003961 FN3_dom
IPR036116 FN3_sf
IPR013783 Ig-like_fold
PfamiView protein in Pfam
PF00041 fn3, 7 hits
SMARTiView protein in SMART
SM00060 FN3, 9 hits
SUPFAMiSSF49265 SSF49265, 6 hits
PROSITEiView protein in PROSITE
PS50853 FN3, 9 hits

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiFND3A_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9Y2H6
Secondary accession number(s): B4DYG1
, Q5HYC9, Q5JVF8, Q5JVF9, Q6EVH3, Q6EVH4, Q6N020, Q6P9D5, Q6ZME4, Q9H1W1
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 19, 2004
Last sequence update: July 28, 2009
Last modified: September 18, 2019
This is version 166 of the entry and version 4 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Human chromosome 13
    Human chromosome 13: entries, gene names and cross-references to MIM
  6. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
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