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Protein

Fibronectin type-III domain-containing protein 3A

Gene

FNDC3A

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Mediates spermatid-Sertoli adhesion during spermatogenesis.By similarity

GO - Molecular functioni

GO - Biological processi

Names & Taxonomyi

Protein namesi
Recommended name:
Fibronectin type-III domain-containing protein 3A
Alternative name(s):
Human gene expressed in odontoblasts
Gene namesi
Name:FNDC3A
Synonyms:FNDC3, HUGO, KIAA0970
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 13

Organism-specific databases

EuPathDBiHostDB:ENSG00000102531.16
HGNCiHGNC:20296 FNDC3A
MIMi615794 gene
neXtProtiNX_Q9Y2H6

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei1177 – 1197HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Golgi apparatus, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi22862
OpenTargetsiENSG00000102531
PharmGKBiPA128394588

Polymorphism and mutation databases

BioMutaiFNDC3A
DMDMi254763442

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000873211 – 1198Fibronectin type-III domain-containing protein 3AAdd BLAST1198

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei203PhosphoserineCombined sources1
Modified residuei207PhosphoserineBy similarity1
Modified residuei213PhosphoserineCombined sources1
Modified residuei384N6-acetyllysineCombined sources1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiQ9Y2H6
PaxDbiQ9Y2H6
PeptideAtlasiQ9Y2H6
PRIDEiQ9Y2H6
ProteomicsDBi85785
85786 [Q9Y2H6-2]

PTM databases

iPTMnetiQ9Y2H6
PhosphoSitePlusiQ9Y2H6
SwissPalmiQ9Y2H6

Expressioni

Tissue specificityi

Expressed in the odontoblast and nerves in the dental pulp. Also expressed in trachea and to a lesser extent in the brain, liver, lung and kidney.1 Publication

Gene expression databases

BgeeiENSG00000102531 Expressed in 236 organ(s), highest expression level in chorionic villus
CleanExiHS_FNDC3A
ExpressionAtlasiQ9Y2H6 baseline and differential
GenevisibleiQ9Y2H6 HS

Organism-specific databases

HPAiHPA008927
HPA012825

Interactioni

Protein-protein interaction databases

BioGridi116530, 44 interactors
IntActiQ9Y2H6, 29 interactors
STRINGi9606.ENSP00000417257

Structurei

Secondary structure

11198
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliQ9Y2H6
SMRiQ9Y2H6
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ9Y2H6

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini268 – 369Fibronectin type-III 1PROSITE-ProRule annotationAdd BLAST102
Domaini373 – 465Fibronectin type-III 2PROSITE-ProRule annotationAdd BLAST93
Domaini469 – 562Fibronectin type-III 3PROSITE-ProRule annotationAdd BLAST94
Domaini566 – 660Fibronectin type-III 4PROSITE-ProRule annotationAdd BLAST95
Domaini664 – 757Fibronectin type-III 5PROSITE-ProRule annotationAdd BLAST94
Domaini761 – 851Fibronectin type-III 6PROSITE-ProRule annotationAdd BLAST91
Domaini861 – 950Fibronectin type-III 7PROSITE-ProRule annotationAdd BLAST90
Domaini951 – 1045Fibronectin type-III 8PROSITE-ProRule annotationAdd BLAST95
Domaini1046 – 1151Fibronectin type-III 9PROSITE-ProRule annotationAdd BLAST106

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi68 – 133Pro-richAdd BLAST66

Sequence similaritiesi

Belongs to the FNDC3 family.Curated

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IE8R Eukaryota
ENOG410XNUW LUCA
GeneTreeiENSGT00860000133770
HOVERGENiHBG100680
InParanoidiQ9Y2H6
OMAiCQDPVGH
OrthoDBiEOG091G047U
PhylomeDBiQ9Y2H6
TreeFamiTF316401

Family and domain databases

CDDicd00063 FN3, 9 hits
Gene3Di2.60.40.10, 9 hits
InterProiView protein in InterPro
IPR003961 FN3_dom
IPR036116 FN3_sf
IPR013783 Ig-like_fold
PfamiView protein in Pfam
PF00041 fn3, 7 hits
SMARTiView protein in SMART
SM00060 FN3, 9 hits
SUPFAMiSSF49265 SSF49265, 6 hits
PROSITEiView protein in PROSITE
PS50853 FN3, 9 hits

Sequences (2+)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative promoter usage. AlignAdd to basket

This entry has 2 described isoforms and 3 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q9Y2H6-1) [UniParc]FASTAAdd to basket
Also known as: HUGO1

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MAEHPPLLDT TQILSSDISL LSAPIVSADG TQQVILVQVN PGEAFTIRRE
60 70 80 90 100
DGQFQCITGP AQVPMMSPNG SVPPIYVPPG YAPQVIEDNG VRRVVVVPQA
110 120 130 140 150
PEFHPGSHTV LHRSPHPPLP GFIPVPTMMP PPPRHMYSPV TGAGDMTTQY
160 170 180 190 200
MPQYQSSQVY GDVDAHSTHG RSNFRDERSS KTYERLQKKL KDRQGTQKDK
210 220 230 240 250
MSSPPSSPQK CPSPINEHNG LIKGQIAGGI NTGSAKIKSG KGKGGTQVDT
260 270 280 290 300
EIEEKDEETK AFEALLSNIV KPVASDIQAR TVVLTWSPPS SLINGETDES
310 320 330 340 350
SVPELYGYEV LISSTGKDGK YKSVYVGEET NITLNDLKPA MDYHAKVQAE
360 370 380 390 400
YNSIKGTPSE AEIFTTLSCE PDIPNPPRIA NRTKNSLTLQ WKAPSDNGSK
410 420 430 440 450
IQNFVLEWDE GKGNGEFCQC YMGSQKQFKI TKLSPAMGCK FRLSARNDYG
460 470 480 490 500
TSGFSEEVLY YTSGCAPSMP ASPVLTKAGI TWLSLQWSKP SGTPSDEGIS
510 520 530 540 550
YILEMEEETS GYGFKPKYDG EDLAYTVKNL RRSTKYKFKV IAYNSEGKSN
560 570 580 590 600
PSEVVEFTTC PDKPGIPVKP SVKGKIHSHS FKITWDPPKD NGGATINKYV
610 620 630 640 650
VEMAEGSNGN KWEMIYSGAT REHLCDRLNP GCFYRLRVYC ISDGGQSAVS
660 670 680 690 700
ESLLVQTPAV PPGPCLPPRL QGRPKAKEIQ LRWGPPLVDG GSPISCYSVE
710 720 730 740 750
MSPIEKDEPR EVYQGSEVEC TVSSLLPGKT YSFRLRAANK MGFGPFSEKC
760 770 780 790 800
DITTAPGPPD QCKPPQVTCR SATCAQVNWE VPLSNGTDVT EYRLEWGGVE
810 820 830 840 850
GSMQICYCGP GLSYEIKGLS PATTYYCRVQ ALSVVGAGPF SEVVACVTPP
860 870 880 890 900
SVPGIVTCLQ EISDDEIENP HYSPSTCLAI SWEKPCDHGS EILAYSIDFG
910 920 930 940 950
DKQSLTVGKV TSYIINNLQP DTTYRIRIQA LNSLGAGPFS HMIKLKTKPL
960 970 980 990 1000
PPDPPRLECV AFSHQNLKLK WGEGTPKTLS TDSIQYHLQM EDKNGRFVSL
1010 1020 1030 1040 1050
YRGPCHTYKV QRLNESTSYK FCIQACNEAG EGPLSQEYIF TTPKSVPAAL
1060 1070 1080 1090 1100
KAPKIEKVND HICEITWECL QPMKGDPVIY SLQVMLGKDS EFKQIYKGPD
1110 1120 1130 1140 1150
SSFRYSSLQL NCEYRFRVCA IRQCQDSLGH QDLVGPYSTT VLFISQRTEP
1160 1170 1180 1190
PASTNRDTVE STRTRRALSD EQCAAVILVL FAFFSILIAF IIQYFVIK
Length:1,198
Mass (Da):131,852
Last modified:July 28, 2009 - v4
Checksum:i2809E41E89BDD095
GO
Isoform 2 (identifier: Q9Y2H6-2) [UniParc]FASTAAdd to basket
Also known as: HUGO2

The sequence of this isoform differs from the canonical sequence as follows:
     1-56: Missing.
     57-58: IT → MS

Show »
Length:1,142
Mass (Da):125,822
Checksum:i2136F2F51012A73F
GO

Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
G5E9X3G5E9X3_HUMAN
Fibronectin type III domain contain...
FNDC3A hCG_1811703
684Annotation score:
H7C507H7C507_HUMAN
Fibronectin type-III domain-contain...
FNDC3A
139Annotation score:
A0A087X1M6A0A087X1M6_HUMAN
Fibronectin type-III domain-contain...
FNDC3A
326Annotation score:

Sequence cautioni

The sequence BAA76814 differs from that shown. Reason: Erroneous initiation.Curated
The sequence BAD18784 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti53Q → R in CAI45989 (PubMed:17974005).Curated1
Sequence conflicti350E → G in CAE45852 (PubMed:17974005).Curated1
Sequence conflicti501Y → H in CAE45852 (PubMed:17974005).Curated1
Sequence conflicti839P → R in AAH60816 (PubMed:15489334).Curated1
Sequence conflicti839P → R in AAH70072 (PubMed:15489334).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_059655107S → G. Corresponds to variant dbSNP:rs34539036Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0377231 – 56Missing in isoform 2. 4 PublicationsAdd BLAST56
Alternative sequenceiVSP_03772457 – 58IT → MS in isoform 2. 4 Publications2

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ749706 mRNA Translation: CAG44602.1
AJ749707 mRNA Translation: CAG44603.1
AB023187 mRNA Translation: BAA76814.2 Different initiation.
AK172814 mRNA Translation: BAD18784.1 Different initiation.
AK302415 mRNA Translation: BAG63723.1
BX640739 mRNA Translation: CAE45852.1
BX648141 mRNA Translation: CAI45989.1
AL161421 Genomic DNA No translation available.
AL359184 Genomic DNA No translation available.
AL137000 Genomic DNA No translation available.
CH471075 Genomic DNA Translation: EAX08804.1
CH471075 Genomic DNA Translation: EAX08806.1
BC060816 mRNA Translation: AAH60816.1
BC070072 mRNA Translation: AAH70072.1
BC132812 mRNA Translation: AAI32813.1
BC136617 mRNA Translation: AAI36618.1
BC144301 mRNA Translation: AAI44302.1
CCDSiCCDS41886.1 [Q9Y2H6-1]
CCDS9413.2 [Q9Y2H6-2]
RefSeqiNP_001073141.1, NM_001079673.1 [Q9Y2H6-1]
NP_001265367.1, NM_001278438.1 [Q9Y2H6-1]
NP_055738.3, NM_014923.4 [Q9Y2H6-2]
XP_011533299.1, XM_011534997.2
XP_016875929.1, XM_017020440.1 [Q9Y2H6-1]
XP_016875930.1, XM_017020441.1
XP_016875931.1, XM_017020442.1
UniGeneiHs.508010

Genome annotation databases

EnsembliENST00000398316; ENSP00000381362; ENSG00000102531 [Q9Y2H6-2]
ENST00000492622; ENSP00000417257; ENSG00000102531 [Q9Y2H6-1]
ENST00000541916; ENSP00000441831; ENSG00000102531 [Q9Y2H6-1]
GeneIDi22862
KEGGihsa:22862
UCSCiuc001vcm.3 human [Q9Y2H6-1]

Keywords - Coding sequence diversityi

Alternative promoter usage, Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ749706 mRNA Translation: CAG44602.1
AJ749707 mRNA Translation: CAG44603.1
AB023187 mRNA Translation: BAA76814.2 Different initiation.
AK172814 mRNA Translation: BAD18784.1 Different initiation.
AK302415 mRNA Translation: BAG63723.1
BX640739 mRNA Translation: CAE45852.1
BX648141 mRNA Translation: CAI45989.1
AL161421 Genomic DNA No translation available.
AL359184 Genomic DNA No translation available.
AL137000 Genomic DNA No translation available.
CH471075 Genomic DNA Translation: EAX08804.1
CH471075 Genomic DNA Translation: EAX08806.1
BC060816 mRNA Translation: AAH60816.1
BC070072 mRNA Translation: AAH70072.1
BC132812 mRNA Translation: AAI32813.1
BC136617 mRNA Translation: AAI36618.1
BC144301 mRNA Translation: AAI44302.1
CCDSiCCDS41886.1 [Q9Y2H6-1]
CCDS9413.2 [Q9Y2H6-2]
RefSeqiNP_001073141.1, NM_001079673.1 [Q9Y2H6-1]
NP_001265367.1, NM_001278438.1 [Q9Y2H6-1]
NP_055738.3, NM_014923.4 [Q9Y2H6-2]
XP_011533299.1, XM_011534997.2
XP_016875929.1, XM_017020440.1 [Q9Y2H6-1]
XP_016875930.1, XM_017020441.1
XP_016875931.1, XM_017020442.1
UniGeneiHs.508010

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1WK0NMR-A256-379[»]
1X3DNMR-A361-465[»]
1X4XNMR-A759-851[»]
1X5XNMR-A467-562[»]
2CRMNMR-A554-660[»]
2CRZNMR-A661-757[»]
ProteinModelPortaliQ9Y2H6
SMRiQ9Y2H6
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi116530, 44 interactors
IntActiQ9Y2H6, 29 interactors
STRINGi9606.ENSP00000417257

PTM databases

iPTMnetiQ9Y2H6
PhosphoSitePlusiQ9Y2H6
SwissPalmiQ9Y2H6

Polymorphism and mutation databases

BioMutaiFNDC3A
DMDMi254763442

Proteomic databases

EPDiQ9Y2H6
PaxDbiQ9Y2H6
PeptideAtlasiQ9Y2H6
PRIDEiQ9Y2H6
ProteomicsDBi85785
85786 [Q9Y2H6-2]

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000398316; ENSP00000381362; ENSG00000102531 [Q9Y2H6-2]
ENST00000492622; ENSP00000417257; ENSG00000102531 [Q9Y2H6-1]
ENST00000541916; ENSP00000441831; ENSG00000102531 [Q9Y2H6-1]
GeneIDi22862
KEGGihsa:22862
UCSCiuc001vcm.3 human [Q9Y2H6-1]

Organism-specific databases

CTDi22862
DisGeNETi22862
EuPathDBiHostDB:ENSG00000102531.16
GeneCardsiFNDC3A
H-InvDBiHIX0011312
HGNCiHGNC:20296 FNDC3A
HPAiHPA008927
HPA012825
MIMi615794 gene
neXtProtiNX_Q9Y2H6
OpenTargetsiENSG00000102531
PharmGKBiPA128394588
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IE8R Eukaryota
ENOG410XNUW LUCA
GeneTreeiENSGT00860000133770
HOVERGENiHBG100680
InParanoidiQ9Y2H6
OMAiCQDPVGH
OrthoDBiEOG091G047U
PhylomeDBiQ9Y2H6
TreeFamiTF316401

Miscellaneous databases

ChiTaRSiFNDC3A human
EvolutionaryTraceiQ9Y2H6
GeneWikiiFNDC3A
GenomeRNAii22862
PROiPR:Q9Y2H6
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000102531 Expressed in 236 organ(s), highest expression level in chorionic villus
CleanExiHS_FNDC3A
ExpressionAtlasiQ9Y2H6 baseline and differential
GenevisibleiQ9Y2H6 HS

Family and domain databases

CDDicd00063 FN3, 9 hits
Gene3Di2.60.40.10, 9 hits
InterProiView protein in InterPro
IPR003961 FN3_dom
IPR036116 FN3_sf
IPR013783 Ig-like_fold
PfamiView protein in Pfam
PF00041 fn3, 7 hits
SMARTiView protein in SMART
SM00060 FN3, 9 hits
SUPFAMiSSF49265 SSF49265, 6 hits
PROSITEiView protein in PROSITE
PS50853 FN3, 9 hits
ProtoNetiSearch...

Entry informationi

Entry nameiFND3A_HUMAN
AccessioniPrimary (citable) accession number: Q9Y2H6
Secondary accession number(s): B4DYG1
, Q5HYC9, Q5JVF8, Q5JVF9, Q6EVH3, Q6EVH4, Q6N020, Q6P9D5, Q6ZME4, Q9H1W1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 19, 2004
Last sequence update: July 28, 2009
Last modified: November 7, 2018
This is version 159 of the entry and version 4 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. Human chromosome 13
    Human chromosome 13: entries, gene names and cross-references to MIM
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Main funding by: National Institutes of Health

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