UniProtKB - Q9Y2H6 (FND3A_HUMAN)
Protein
Fibronectin type-III domain-containing protein 3A
Gene
FNDC3A
Organism
Homo sapiens (Human)
Status
Functioni
Mediates spermatid-Sertoli adhesion during spermatogenesis.By similarity
GO - Molecular functioni
- RNA binding Source: UniProtKB
GO - Biological processi
- cell-cell adhesion Source: Ensembl
- fertilization Source: Ensembl
- Sertoli cell development Source: Ensembl
- spermatid development Source: Ensembl
Enzyme and pathway databases
PathwayCommonsi | Q9Y2H6 |
Names & Taxonomyi
Protein namesi | Recommended name: Fibronectin type-III domain-containing protein 3AAlternative name(s): Human gene expressed in odontoblasts |
Gene namesi | Name:FNDC3A Synonyms:FNDC3, HUGO, KIAA0970 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:20296, FNDC3A |
MIMi | 615794, gene |
neXtProti | NX_Q9Y2H6 |
VEuPathDBi | HostDB:ENSG00000102531.16 |
Subcellular locationi
Golgi apparatus
- Golgi apparatus membrane Curated; Single-pass membrane protein Curated
Cytosol
- cytosol Source: Ensembl
Golgi apparatus
- Golgi apparatus Source: UniProtKB
- Golgi membrane Source: UniProtKB-SubCell
Other locations
- acrosomal vesicle Source: Ensembl
- integral component of membrane Source: UniProtKB-KW
- membrane Source: UniProtKB
- vesicle membrane Source: Ensembl
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Transmembranei | 1177 – 1197 | HelicalSequence analysisAdd BLAST | 21 |
Keywords - Cellular componenti
Golgi apparatus, MembranePathology & Biotechi
Organism-specific databases
DisGeNETi | 22862 |
OpenTargetsi | ENSG00000102531 |
PharmGKBi | PA128394588 |
Miscellaneous databases
Pharosi | Q9Y2H6, Tbio |
Genetic variation databases
BioMutai | FNDC3A |
DMDMi | 254763442 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000087321 | 1 – 1198 | Fibronectin type-III domain-containing protein 3AAdd BLAST | 1198 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 203 | PhosphoserineCombined sources | 1 | |
Modified residuei | 207 | PhosphoserineBy similarity | 1 | |
Modified residuei | 213 | PhosphoserineCombined sources | 1 | |
Modified residuei | 384 | N6-acetyllysineCombined sources | 1 |
Keywords - PTMi
Acetylation, PhosphoproteinProteomic databases
EPDi | Q9Y2H6 |
jPOSTi | Q9Y2H6 |
MassIVEi | Q9Y2H6 |
PaxDbi | Q9Y2H6 |
PeptideAtlasi | Q9Y2H6 |
PRIDEi | Q9Y2H6 |
ProteomicsDBi | 85785 [Q9Y2H6-1] 85786 [Q9Y2H6-2] |
PTM databases
iPTMneti | Q9Y2H6 |
PhosphoSitePlusi | Q9Y2H6 |
SwissPalmi | Q9Y2H6 |
Expressioni
Tissue specificityi
Expressed in the odontoblast and nerves in the dental pulp. Also expressed in trachea and to a lesser extent in the brain, liver, lung and kidney.1 Publication
Gene expression databases
Bgeei | ENSG00000102531, Expressed in chorionic villus and 247 other tissues |
ExpressionAtlasi | Q9Y2H6, baseline and differential |
Genevisiblei | Q9Y2H6, HS |
Organism-specific databases
HPAi | ENSG00000102531, Low tissue specificity |
Interactioni
Protein-protein interaction databases
BioGRIDi | 116530, 67 interactors |
IntActi | Q9Y2H6, 48 interactors |
STRINGi | 9606.ENSP00000441831 |
Miscellaneous databases
RNActi | Q9Y2H6, protein |
Structurei
Secondary structure
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details3D structure databases
BMRBi | Q9Y2H6 |
SMRi | Q9Y2H6 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | Q9Y2H6 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 268 – 369 | Fibronectin type-III 1PROSITE-ProRule annotationAdd BLAST | 102 | |
Domaini | 373 – 465 | Fibronectin type-III 2PROSITE-ProRule annotationAdd BLAST | 93 | |
Domaini | 469 – 562 | Fibronectin type-III 3PROSITE-ProRule annotationAdd BLAST | 94 | |
Domaini | 566 – 660 | Fibronectin type-III 4PROSITE-ProRule annotationAdd BLAST | 95 | |
Domaini | 664 – 757 | Fibronectin type-III 5PROSITE-ProRule annotationAdd BLAST | 94 | |
Domaini | 761 – 851 | Fibronectin type-III 6PROSITE-ProRule annotationAdd BLAST | 91 | |
Domaini | 861 – 950 | Fibronectin type-III 7PROSITE-ProRule annotationAdd BLAST | 90 | |
Domaini | 951 – 1045 | Fibronectin type-III 8PROSITE-ProRule annotationAdd BLAST | 95 | |
Domaini | 1046 – 1151 | Fibronectin type-III 9PROSITE-ProRule annotationAdd BLAST | 106 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 68 – 133 | Pro-richAdd BLAST | 66 |
Sequence similaritiesi
Belongs to the FNDC3 family.Curated
Keywords - Domaini
Repeat, Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | ENOG502QRT8, Eukaryota |
GeneTreei | ENSGT00940000159319 |
HOGENOMi | CLU_004152_0_0_1 |
InParanoidi | Q9Y2H6 |
OMAi | AYFVAQD |
PhylomeDBi | Q9Y2H6 |
TreeFami | TF316401 |
Family and domain databases
CDDi | cd00063, FN3, 9 hits |
Gene3Di | 2.60.40.10, 9 hits |
InterProi | View protein in InterPro IPR003961, FN3_dom IPR036116, FN3_sf IPR013783, Ig-like_fold |
Pfami | View protein in Pfam PF00041, fn3, 7 hits |
SMARTi | View protein in SMART SM00060, FN3, 9 hits |
SUPFAMi | SSF49265, SSF49265, 6 hits |
PROSITEi | View protein in PROSITE PS50853, FN3, 9 hits |
s (2+)i Sequence
Sequence statusi: Complete.
This entry describes 2 produced by isoformsialternative promoter usage. AlignAdd to basketThis entry has 2 described isoforms and 3 potential isoforms that are computationally mapped.Show allAlign All
Isoform 1 (identifier: Q9Y2H6-1) [UniParc]FASTAAdd to basket
Also known as: HUGO1
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MAEHPPLLDT TQILSSDISL LSAPIVSADG TQQVILVQVN PGEAFTIRRE
60 70 80 90 100
DGQFQCITGP AQVPMMSPNG SVPPIYVPPG YAPQVIEDNG VRRVVVVPQA
110 120 130 140 150
PEFHPGSHTV LHRSPHPPLP GFIPVPTMMP PPPRHMYSPV TGAGDMTTQY
160 170 180 190 200
MPQYQSSQVY GDVDAHSTHG RSNFRDERSS KTYERLQKKL KDRQGTQKDK
210 220 230 240 250
MSSPPSSPQK CPSPINEHNG LIKGQIAGGI NTGSAKIKSG KGKGGTQVDT
260 270 280 290 300
EIEEKDEETK AFEALLSNIV KPVASDIQAR TVVLTWSPPS SLINGETDES
310 320 330 340 350
SVPELYGYEV LISSTGKDGK YKSVYVGEET NITLNDLKPA MDYHAKVQAE
360 370 380 390 400
YNSIKGTPSE AEIFTTLSCE PDIPNPPRIA NRTKNSLTLQ WKAPSDNGSK
410 420 430 440 450
IQNFVLEWDE GKGNGEFCQC YMGSQKQFKI TKLSPAMGCK FRLSARNDYG
460 470 480 490 500
TSGFSEEVLY YTSGCAPSMP ASPVLTKAGI TWLSLQWSKP SGTPSDEGIS
510 520 530 540 550
YILEMEEETS GYGFKPKYDG EDLAYTVKNL RRSTKYKFKV IAYNSEGKSN
560 570 580 590 600
PSEVVEFTTC PDKPGIPVKP SVKGKIHSHS FKITWDPPKD NGGATINKYV
610 620 630 640 650
VEMAEGSNGN KWEMIYSGAT REHLCDRLNP GCFYRLRVYC ISDGGQSAVS
660 670 680 690 700
ESLLVQTPAV PPGPCLPPRL QGRPKAKEIQ LRWGPPLVDG GSPISCYSVE
710 720 730 740 750
MSPIEKDEPR EVYQGSEVEC TVSSLLPGKT YSFRLRAANK MGFGPFSEKC
760 770 780 790 800
DITTAPGPPD QCKPPQVTCR SATCAQVNWE VPLSNGTDVT EYRLEWGGVE
810 820 830 840 850
GSMQICYCGP GLSYEIKGLS PATTYYCRVQ ALSVVGAGPF SEVVACVTPP
860 870 880 890 900
SVPGIVTCLQ EISDDEIENP HYSPSTCLAI SWEKPCDHGS EILAYSIDFG
910 920 930 940 950
DKQSLTVGKV TSYIINNLQP DTTYRIRIQA LNSLGAGPFS HMIKLKTKPL
960 970 980 990 1000
PPDPPRLECV AFSHQNLKLK WGEGTPKTLS TDSIQYHLQM EDKNGRFVSL
1010 1020 1030 1040 1050
YRGPCHTYKV QRLNESTSYK FCIQACNEAG EGPLSQEYIF TTPKSVPAAL
1060 1070 1080 1090 1100
KAPKIEKVND HICEITWECL QPMKGDPVIY SLQVMLGKDS EFKQIYKGPD
1110 1120 1130 1140 1150
SSFRYSSLQL NCEYRFRVCA IRQCQDSLGH QDLVGPYSTT VLFISQRTEP
1160 1170 1180 1190
PASTNRDTVE STRTRRALSD EQCAAVILVL FAFFSILIAF IIQYFVIK
Computationally mapped potential isoform sequencesi
There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketG5E9X3 | G5E9X3_HUMAN | Fibronectin type III domain contain... | FNDC3A hCG_1811703 | 684 | Annotation score: | ||
A0A087X1M6 | A0A087X1M6_HUMAN | Fibronectin type-III domain-contain... | FNDC3A | 326 | Annotation score: | ||
H7C507 | H7C507_HUMAN | Fibronectin type-III domain-contain... | FNDC3A | 139 | Annotation score: |
Sequence cautioni
The sequence BAA76814 differs from that shown. Reason: Erroneous initiation.Curated
The sequence BAD18784 differs from that shown. Reason: Erroneous initiation.Curated
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 53 | Q → R in CAI45989 (PubMed:17974005).Curated | 1 | |
Sequence conflicti | 350 | E → G in CAE45852 (PubMed:17974005).Curated | 1 | |
Sequence conflicti | 501 | Y → H in CAE45852 (PubMed:17974005).Curated | 1 | |
Sequence conflicti | 839 | P → R in AAH60816 (PubMed:15489334).Curated | 1 | |
Sequence conflicti | 839 | P → R in AAH70072 (PubMed:15489334).Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_059655 | 107 | S → G. Corresponds to variant dbSNP:rs34539036EnsemblClinVar. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_037723 | 1 – 56 | Missing in isoform 2. 4 PublicationsAdd BLAST | 56 | |
Alternative sequenceiVSP_037724 | 57 – 58 | IT → MS in isoform 2. 4 Publications | 2 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AJ749706 mRNA Translation: CAG44602.1 AJ749707 mRNA Translation: CAG44603.1 AB023187 mRNA Translation: BAA76814.2 Different initiation. AK172814 mRNA Translation: BAD18784.1 Different initiation. AK302415 mRNA Translation: BAG63723.1 BX640739 mRNA Translation: CAE45852.1 BX648141 mRNA Translation: CAI45989.1 AL161421 Genomic DNA No translation available. AL359184 Genomic DNA No translation available. AL137000 Genomic DNA No translation available. CH471075 Genomic DNA Translation: EAX08804.1 CH471075 Genomic DNA Translation: EAX08806.1 BC060816 mRNA Translation: AAH60816.1 BC070072 mRNA Translation: AAH70072.1 BC132812 mRNA Translation: AAI32813.1 BC136617 mRNA Translation: AAI36618.1 BC144301 mRNA Translation: AAI44302.1 |
CCDSi | CCDS41886.1 [Q9Y2H6-1] CCDS9413.2 [Q9Y2H6-2] |
RefSeqi | NP_001073141.1, NM_001079673.1 [Q9Y2H6-1] NP_001265367.1, NM_001278438.1 [Q9Y2H6-1] NP_055738.3, NM_014923.4 [Q9Y2H6-2] XP_011533299.1, XM_011534997.2 XP_016875929.1, XM_017020440.1 [Q9Y2H6-1] XP_016875930.1, XM_017020441.1 XP_016875931.1, XM_017020442.1 |
Genome annotation databases
Ensembli | ENST00000398316; ENSP00000381362; ENSG00000102531 [Q9Y2H6-2] ENST00000492622; ENSP00000417257; ENSG00000102531 [Q9Y2H6-1] ENST00000541916; ENSP00000441831; ENSG00000102531 [Q9Y2H6-1] |
GeneIDi | 22862 |
KEGGi | hsa:22862 |
UCSCi | uc001vcm.3, human [Q9Y2H6-1] |
Keywords - Coding sequence diversityi
Alternative promoter usageSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AJ749706 mRNA Translation: CAG44602.1 AJ749707 mRNA Translation: CAG44603.1 AB023187 mRNA Translation: BAA76814.2 Different initiation. AK172814 mRNA Translation: BAD18784.1 Different initiation. AK302415 mRNA Translation: BAG63723.1 BX640739 mRNA Translation: CAE45852.1 BX648141 mRNA Translation: CAI45989.1 AL161421 Genomic DNA No translation available. AL359184 Genomic DNA No translation available. AL137000 Genomic DNA No translation available. CH471075 Genomic DNA Translation: EAX08804.1 CH471075 Genomic DNA Translation: EAX08806.1 BC060816 mRNA Translation: AAH60816.1 BC070072 mRNA Translation: AAH70072.1 BC132812 mRNA Translation: AAI32813.1 BC136617 mRNA Translation: AAI36618.1 BC144301 mRNA Translation: AAI44302.1 |
CCDSi | CCDS41886.1 [Q9Y2H6-1] CCDS9413.2 [Q9Y2H6-2] |
RefSeqi | NP_001073141.1, NM_001079673.1 [Q9Y2H6-1] NP_001265367.1, NM_001278438.1 [Q9Y2H6-1] NP_055738.3, NM_014923.4 [Q9Y2H6-2] XP_011533299.1, XM_011534997.2 XP_016875929.1, XM_017020440.1 [Q9Y2H6-1] XP_016875930.1, XM_017020441.1 XP_016875931.1, XM_017020442.1 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
1WK0 | NMR | - | A | 256-379 | [»] | |
1X3D | NMR | - | A | 361-465 | [»] | |
1X4X | NMR | - | A | 759-851 | [»] | |
1X5X | NMR | - | A | 467-562 | [»] | |
2CRM | NMR | - | A | 554-660 | [»] | |
2CRZ | NMR | - | A | 661-757 | [»] | |
BMRBi | Q9Y2H6 | |||||
SMRi | Q9Y2H6 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 116530, 67 interactors |
IntActi | Q9Y2H6, 48 interactors |
STRINGi | 9606.ENSP00000441831 |
PTM databases
iPTMneti | Q9Y2H6 |
PhosphoSitePlusi | Q9Y2H6 |
SwissPalmi | Q9Y2H6 |
Genetic variation databases
BioMutai | FNDC3A |
DMDMi | 254763442 |
Proteomic databases
EPDi | Q9Y2H6 |
jPOSTi | Q9Y2H6 |
MassIVEi | Q9Y2H6 |
PaxDbi | Q9Y2H6 |
PeptideAtlasi | Q9Y2H6 |
PRIDEi | Q9Y2H6 |
ProteomicsDBi | 85785 [Q9Y2H6-1] 85786 [Q9Y2H6-2] |
Protocols and materials databases
Antibodypediai | 2293, 119 antibodies |
Genome annotation databases
Ensembli | ENST00000398316; ENSP00000381362; ENSG00000102531 [Q9Y2H6-2] ENST00000492622; ENSP00000417257; ENSG00000102531 [Q9Y2H6-1] ENST00000541916; ENSP00000441831; ENSG00000102531 [Q9Y2H6-1] |
GeneIDi | 22862 |
KEGGi | hsa:22862 |
UCSCi | uc001vcm.3, human [Q9Y2H6-1] |
Organism-specific databases
CTDi | 22862 |
DisGeNETi | 22862 |
GeneCardsi | FNDC3A |
HGNCi | HGNC:20296, FNDC3A |
HPAi | ENSG00000102531, Low tissue specificity |
MIMi | 615794, gene |
neXtProti | NX_Q9Y2H6 |
OpenTargetsi | ENSG00000102531 |
PharmGKBi | PA128394588 |
VEuPathDBi | HostDB:ENSG00000102531.16 |
HUGEi | Search... |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | ENOG502QRT8, Eukaryota |
GeneTreei | ENSGT00940000159319 |
HOGENOMi | CLU_004152_0_0_1 |
InParanoidi | Q9Y2H6 |
OMAi | AYFVAQD |
PhylomeDBi | Q9Y2H6 |
TreeFami | TF316401 |
Enzyme and pathway databases
PathwayCommonsi | Q9Y2H6 |
Miscellaneous databases
BioGRID-ORCSi | 22862, 6 hits in 874 CRISPR screens |
ChiTaRSi | FNDC3A, human |
EvolutionaryTracei | Q9Y2H6 |
GeneWikii | FNDC3A |
GenomeRNAii | 22862 |
Pharosi | Q9Y2H6, Tbio |
PROi | PR:Q9Y2H6 |
RNActi | Q9Y2H6, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000102531, Expressed in chorionic villus and 247 other tissues |
ExpressionAtlasi | Q9Y2H6, baseline and differential |
Genevisiblei | Q9Y2H6, HS |
Family and domain databases
CDDi | cd00063, FN3, 9 hits |
Gene3Di | 2.60.40.10, 9 hits |
InterProi | View protein in InterPro IPR003961, FN3_dom IPR036116, FN3_sf IPR013783, Ig-like_fold |
Pfami | View protein in Pfam PF00041, fn3, 7 hits |
SMARTi | View protein in SMART SM00060, FN3, 9 hits |
SUPFAMi | SSF49265, SSF49265, 6 hits |
PROSITEi | View protein in PROSITE PS50853, FN3, 9 hits |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | FND3A_HUMAN | |
Accessioni | Q9Y2H6Primary (citable) accession number: Q9Y2H6 Secondary accession number(s): B4DYG1 Q9H1W1 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | July 19, 2004 |
Last sequence update: | July 28, 2009 | |
Last modified: | February 10, 2021 | |
This is version 174 of the entry and version 4 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- Human chromosome 13
Human chromosome 13: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families