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Entry version 166 (18 Sep 2019)
Sequence version 4 (28 Jul 2009)
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Protein

Fibronectin type-III domain-containing protein 3A

Gene

FNDC3A

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Mediates spermatid-Sertoli adhesion during spermatogenesis.By similarity

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Fibronectin type-III domain-containing protein 3A
Alternative name(s):
Human gene expressed in odontoblasts
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:FNDC3A
Synonyms:FNDC3, HUGO, KIAA0970
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 13

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:20296 FNDC3A

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
615794 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q9Y2H6

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei1177 – 1197HelicalSequence analysisAdd BLAST21

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Golgi apparatus, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
22862

Open Targets

More...
OpenTargetsi
ENSG00000102531

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA128394588

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q9Y2H6

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
FNDC3A

Domain mapping of disease mutations (DMDM)

More...
DMDMi
254763442

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000873211 – 1198Fibronectin type-III domain-containing protein 3AAdd BLAST1198

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei203PhosphoserineCombined sources1
Modified residuei207PhosphoserineBy similarity1
Modified residuei213PhosphoserineCombined sources1
Modified residuei384N6-acetyllysineCombined sources1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q9Y2H6

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q9Y2H6

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
Q9Y2H6

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q9Y2H6

PeptideAtlas

More...
PeptideAtlasi
Q9Y2H6

PRoteomics IDEntifications database

More...
PRIDEi
Q9Y2H6

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
85785 [Q9Y2H6-1]
85786 [Q9Y2H6-2]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q9Y2H6

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q9Y2H6

SwissPalm database of S-palmitoylation events

More...
SwissPalmi
Q9Y2H6

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed in the odontoblast and nerves in the dental pulp. Also expressed in trachea and to a lesser extent in the brain, liver, lung and kidney.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000102531 Expressed in 236 organ(s), highest expression level in chorionic villus

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q9Y2H6 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q9Y2H6 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA008927
HPA012825

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
116530, 48 interactors

Protein interaction database and analysis system

More...
IntActi
Q9Y2H6, 47 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000441831

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

11198
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q9Y2H6

Database of comparative protein structure models

More...
ModBasei
Search...

Protein Data Bank in Europe - Knowledge Base

More...
PDBe-KBi
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...
EvolutionaryTracei
Q9Y2H6

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini268 – 369Fibronectin type-III 1PROSITE-ProRule annotationAdd BLAST102
Domaini373 – 465Fibronectin type-III 2PROSITE-ProRule annotationAdd BLAST93
Domaini469 – 562Fibronectin type-III 3PROSITE-ProRule annotationAdd BLAST94
Domaini566 – 660Fibronectin type-III 4PROSITE-ProRule annotationAdd BLAST95
Domaini664 – 757Fibronectin type-III 5PROSITE-ProRule annotationAdd BLAST94
Domaini761 – 851Fibronectin type-III 6PROSITE-ProRule annotationAdd BLAST91
Domaini861 – 950Fibronectin type-III 7PROSITE-ProRule annotationAdd BLAST90
Domaini951 – 1045Fibronectin type-III 8PROSITE-ProRule annotationAdd BLAST95
Domaini1046 – 1151Fibronectin type-III 9PROSITE-ProRule annotationAdd BLAST106

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi68 – 133Pro-richAdd BLAST66

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the FNDC3 family.Curated

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410IE8R Eukaryota
ENOG410XNUW LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000159319

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q9Y2H6

Identification of Orthologs from Complete Genome Data

More...
OMAi
AYFVAQD

Database of Orthologous Groups

More...
OrthoDBi
633003at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q9Y2H6

TreeFam database of animal gene trees

More...
TreeFami
TF316401

Family and domain databases

Conserved Domains Database

More...
CDDi
cd00063 FN3, 9 hits

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.60.40.10, 9 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR003961 FN3_dom
IPR036116 FN3_sf
IPR013783 Ig-like_fold

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00041 fn3, 7 hits

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00060 FN3, 9 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF49265 SSF49265, 6 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50853 FN3, 9 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative promoter usage. AlignAdd to basket

This entry has 2 described isoforms and 3 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q9Y2H6-1) [UniParc]FASTAAdd to basket
Also known as: HUGO1

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MAEHPPLLDT TQILSSDISL LSAPIVSADG TQQVILVQVN PGEAFTIRRE
60 70 80 90 100
DGQFQCITGP AQVPMMSPNG SVPPIYVPPG YAPQVIEDNG VRRVVVVPQA
110 120 130 140 150
PEFHPGSHTV LHRSPHPPLP GFIPVPTMMP PPPRHMYSPV TGAGDMTTQY
160 170 180 190 200
MPQYQSSQVY GDVDAHSTHG RSNFRDERSS KTYERLQKKL KDRQGTQKDK
210 220 230 240 250
MSSPPSSPQK CPSPINEHNG LIKGQIAGGI NTGSAKIKSG KGKGGTQVDT
260 270 280 290 300
EIEEKDEETK AFEALLSNIV KPVASDIQAR TVVLTWSPPS SLINGETDES
310 320 330 340 350
SVPELYGYEV LISSTGKDGK YKSVYVGEET NITLNDLKPA MDYHAKVQAE
360 370 380 390 400
YNSIKGTPSE AEIFTTLSCE PDIPNPPRIA NRTKNSLTLQ WKAPSDNGSK
410 420 430 440 450
IQNFVLEWDE GKGNGEFCQC YMGSQKQFKI TKLSPAMGCK FRLSARNDYG
460 470 480 490 500
TSGFSEEVLY YTSGCAPSMP ASPVLTKAGI TWLSLQWSKP SGTPSDEGIS
510 520 530 540 550
YILEMEEETS GYGFKPKYDG EDLAYTVKNL RRSTKYKFKV IAYNSEGKSN
560 570 580 590 600
PSEVVEFTTC PDKPGIPVKP SVKGKIHSHS FKITWDPPKD NGGATINKYV
610 620 630 640 650
VEMAEGSNGN KWEMIYSGAT REHLCDRLNP GCFYRLRVYC ISDGGQSAVS
660 670 680 690 700
ESLLVQTPAV PPGPCLPPRL QGRPKAKEIQ LRWGPPLVDG GSPISCYSVE
710 720 730 740 750
MSPIEKDEPR EVYQGSEVEC TVSSLLPGKT YSFRLRAANK MGFGPFSEKC
760 770 780 790 800
DITTAPGPPD QCKPPQVTCR SATCAQVNWE VPLSNGTDVT EYRLEWGGVE
810 820 830 840 850
GSMQICYCGP GLSYEIKGLS PATTYYCRVQ ALSVVGAGPF SEVVACVTPP
860 870 880 890 900
SVPGIVTCLQ EISDDEIENP HYSPSTCLAI SWEKPCDHGS EILAYSIDFG
910 920 930 940 950
DKQSLTVGKV TSYIINNLQP DTTYRIRIQA LNSLGAGPFS HMIKLKTKPL
960 970 980 990 1000
PPDPPRLECV AFSHQNLKLK WGEGTPKTLS TDSIQYHLQM EDKNGRFVSL
1010 1020 1030 1040 1050
YRGPCHTYKV QRLNESTSYK FCIQACNEAG EGPLSQEYIF TTPKSVPAAL
1060 1070 1080 1090 1100
KAPKIEKVND HICEITWECL QPMKGDPVIY SLQVMLGKDS EFKQIYKGPD
1110 1120 1130 1140 1150
SSFRYSSLQL NCEYRFRVCA IRQCQDSLGH QDLVGPYSTT VLFISQRTEP
1160 1170 1180 1190
PASTNRDTVE STRTRRALSD EQCAAVILVL FAFFSILIAF IIQYFVIK
Length:1,198
Mass (Da):131,852
Last modified:July 28, 2009 - v4
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i2809E41E89BDD095
GO
Isoform 2 (identifier: Q9Y2H6-2) [UniParc]FASTAAdd to basket
Also known as: HUGO2

The sequence of this isoform differs from the canonical sequence as follows:
     1-56: Missing.
     57-58: IT → MS

Show »
Length:1,142
Mass (Da):125,822
Checksum:i2136F2F51012A73F
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
G5E9X3G5E9X3_HUMAN
Fibronectin type III domain contain...
FNDC3A hCG_1811703
684Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A087X1M6A0A087X1M6_HUMAN
Fibronectin type-III domain-contain...
FNDC3A
326Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H7C507H7C507_HUMAN
Fibronectin type-III domain-contain...
FNDC3A
139Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence BAA76814 differs from that shown. Reason: Erroneous initiation.Curated
The sequence BAD18784 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti53Q → R in CAI45989 (PubMed:17974005).Curated1
Sequence conflicti350E → G in CAE45852 (PubMed:17974005).Curated1
Sequence conflicti501Y → H in CAE45852 (PubMed:17974005).Curated1
Sequence conflicti839P → R in AAH60816 (PubMed:15489334).Curated1
Sequence conflicti839P → R in AAH70072 (PubMed:15489334).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_059655107S → G. Corresponds to variant dbSNP:rs34539036Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0377231 – 56Missing in isoform 2. 4 PublicationsAdd BLAST56
Alternative sequenceiVSP_03772457 – 58IT → MS in isoform 2. 4 Publications2

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AJ749706 mRNA Translation: CAG44602.1
AJ749707 mRNA Translation: CAG44603.1
AB023187 mRNA Translation: BAA76814.2 Different initiation.
AK172814 mRNA Translation: BAD18784.1 Different initiation.
AK302415 mRNA Translation: BAG63723.1
BX640739 mRNA Translation: CAE45852.1
BX648141 mRNA Translation: CAI45989.1
AL161421 Genomic DNA No translation available.
AL359184 Genomic DNA No translation available.
AL137000 Genomic DNA No translation available.
CH471075 Genomic DNA Translation: EAX08804.1
CH471075 Genomic DNA Translation: EAX08806.1
BC060816 mRNA Translation: AAH60816.1
BC070072 mRNA Translation: AAH70072.1
BC132812 mRNA Translation: AAI32813.1
BC136617 mRNA Translation: AAI36618.1
BC144301 mRNA Translation: AAI44302.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS41886.1 [Q9Y2H6-1]
CCDS9413.2 [Q9Y2H6-2]

NCBI Reference Sequences

More...
RefSeqi
NP_001073141.1, NM_001079673.1 [Q9Y2H6-1]
NP_001265367.1, NM_001278438.1 [Q9Y2H6-1]
NP_055738.3, NM_014923.4 [Q9Y2H6-2]
XP_011533299.1, XM_011534997.2
XP_016875929.1, XM_017020440.1 [Q9Y2H6-1]
XP_016875930.1, XM_017020441.1
XP_016875931.1, XM_017020442.1

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENST00000398316; ENSP00000381362; ENSG00000102531 [Q9Y2H6-2]
ENST00000492622; ENSP00000417257; ENSG00000102531 [Q9Y2H6-1]
ENST00000541916; ENSP00000441831; ENSG00000102531 [Q9Y2H6-1]

Database of genes from NCBI RefSeq genomes

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GeneIDi
22862

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:22862

UCSC genome browser

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UCSCi
uc001vcm.3 human [Q9Y2H6-1]

Keywords - Coding sequence diversityi

Alternative promoter usage, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ749706 mRNA Translation: CAG44602.1
AJ749707 mRNA Translation: CAG44603.1
AB023187 mRNA Translation: BAA76814.2 Different initiation.
AK172814 mRNA Translation: BAD18784.1 Different initiation.
AK302415 mRNA Translation: BAG63723.1
BX640739 mRNA Translation: CAE45852.1
BX648141 mRNA Translation: CAI45989.1
AL161421 Genomic DNA No translation available.
AL359184 Genomic DNA No translation available.
AL137000 Genomic DNA No translation available.
CH471075 Genomic DNA Translation: EAX08804.1
CH471075 Genomic DNA Translation: EAX08806.1
BC060816 mRNA Translation: AAH60816.1
BC070072 mRNA Translation: AAH70072.1
BC132812 mRNA Translation: AAI32813.1
BC136617 mRNA Translation: AAI36618.1
BC144301 mRNA Translation: AAI44302.1
CCDSiCCDS41886.1 [Q9Y2H6-1]
CCDS9413.2 [Q9Y2H6-2]
RefSeqiNP_001073141.1, NM_001079673.1 [Q9Y2H6-1]
NP_001265367.1, NM_001278438.1 [Q9Y2H6-1]
NP_055738.3, NM_014923.4 [Q9Y2H6-2]
XP_011533299.1, XM_011534997.2
XP_016875929.1, XM_017020440.1 [Q9Y2H6-1]
XP_016875930.1, XM_017020441.1
XP_016875931.1, XM_017020442.1

3D structure databases

Select the link destinations:

Protein Data Bank Europe

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PDBei

Protein Data Bank RCSB

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RCSB PDBi

Protein Data Bank Japan

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PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1WK0NMR-A256-379[»]
1X3DNMR-A361-465[»]
1X4XNMR-A759-851[»]
1X5XNMR-A467-562[»]
2CRMNMR-A554-660[»]
2CRZNMR-A661-757[»]
SMRiQ9Y2H6
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGridi116530, 48 interactors
IntActiQ9Y2H6, 47 interactors
STRINGi9606.ENSP00000441831

PTM databases

iPTMnetiQ9Y2H6
PhosphoSitePlusiQ9Y2H6
SwissPalmiQ9Y2H6

Polymorphism and mutation databases

BioMutaiFNDC3A
DMDMi254763442

Proteomic databases

EPDiQ9Y2H6
jPOSTiQ9Y2H6
MassIVEiQ9Y2H6
PaxDbiQ9Y2H6
PeptideAtlasiQ9Y2H6
PRIDEiQ9Y2H6
ProteomicsDBi85785 [Q9Y2H6-1]
85786 [Q9Y2H6-2]

Genome annotation databases

EnsembliENST00000398316; ENSP00000381362; ENSG00000102531 [Q9Y2H6-2]
ENST00000492622; ENSP00000417257; ENSG00000102531 [Q9Y2H6-1]
ENST00000541916; ENSP00000441831; ENSG00000102531 [Q9Y2H6-1]
GeneIDi22862
KEGGihsa:22862
UCSCiuc001vcm.3 human [Q9Y2H6-1]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
22862
DisGeNETi22862

GeneCards: human genes, protein and diseases

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GeneCardsi
FNDC3A
HGNCiHGNC:20296 FNDC3A
HPAiHPA008927
HPA012825
MIMi615794 gene
neXtProtiNX_Q9Y2H6
OpenTargetsiENSG00000102531
PharmGKBiPA128394588

Human Unidentified Gene-Encoded large proteins database

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HUGEi
Search...

GenAtlas: human gene database

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GenAtlasi
Search...

Phylogenomic databases

eggNOGiENOG410IE8R Eukaryota
ENOG410XNUW LUCA
GeneTreeiENSGT00940000159319
InParanoidiQ9Y2H6
OMAiAYFVAQD
OrthoDBi633003at2759
PhylomeDBiQ9Y2H6
TreeFamiTF316401

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
FNDC3A human
EvolutionaryTraceiQ9Y2H6

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
FNDC3A

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
22862
PharosiQ9Y2H6

Protein Ontology

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PROi
PR:Q9Y2H6

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
Search...

Gene expression databases

BgeeiENSG00000102531 Expressed in 236 organ(s), highest expression level in chorionic villus
ExpressionAtlasiQ9Y2H6 baseline and differential
GenevisibleiQ9Y2H6 HS

Family and domain databases

CDDicd00063 FN3, 9 hits
Gene3Di2.60.40.10, 9 hits
InterProiView protein in InterPro
IPR003961 FN3_dom
IPR036116 FN3_sf
IPR013783 Ig-like_fold
PfamiView protein in Pfam
PF00041 fn3, 7 hits
SMARTiView protein in SMART
SM00060 FN3, 9 hits
SUPFAMiSSF49265 SSF49265, 6 hits
PROSITEiView protein in PROSITE
PS50853 FN3, 9 hits

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiFND3A_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9Y2H6
Secondary accession number(s): B4DYG1
, Q5HYC9, Q5JVF8, Q5JVF9, Q6EVH3, Q6EVH4, Q6N020, Q6P9D5, Q6ZME4, Q9H1W1
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 19, 2004
Last sequence update: July 28, 2009
Last modified: September 18, 2019
This is version 166 of the entry and version 4 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Human chromosome 13
    Human chromosome 13: entries, gene names and cross-references to MIM
  6. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
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