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UniProtKB - Q9Y2H2 (SAC2_HUMAN)

Entry version 140 (12 Aug 2020)
Sequence version 3 (29 Apr 2008)
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Protein

Phosphatidylinositide phosphatase SAC2

Gene

INPP5F

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Inositol 4-phosphatase which mainly acts on phosphatidylinositol 4-phosphate. May be functionally linked to OCRL, which converts phosphatidylinositol 4,5-bisphosphate to phosphatidylinositol, for a sequential dephosphorylation of phosphatidylinositol 4,5-bisphosphate at the 5 and 4 position of inositol, thus playing an important role in the endocytic recycling (PubMed:25869669). Regulator of TF:TFRC and integrins recycling pathway, is also involved in cell migration mechanisms (PubMed:25869669). Modulates AKT/GSK3B pathway by decreasing AKT and GSK3B phosphorylation (PubMed:17322895). Negatively regulates STAT3 signaling pathway through inhibition of STAT3 phosphorylation and translocation to the nucleus (PubMed:25476455). Functionally important modulator of cardiac myocyte size and of the cardiac response to stress (By similarity). May play a role as negative regulator of axon regeneration after central nervous system injuries (By similarity).By similarity3 Publications

Caution

INPP5F has been initially described as an inositol polyphosphate 5-phosphatase.1 Publication

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the 'Function' section describes biophysical and chemical properties, such as maximal absorption, kinetic parameters, pH dependence, redox potentials and temperature dependence.<p><a href='/help/biophysicochemical_properties' target='_top'>More...</a></p>Kineticsi

  1. KM=14.3 µM for PtdIns(4,5)P2 (at pH 6.0)1 Publication

    <p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

    Complete GO annotation on QuickGO ...

    GO - Biological processi

    Complete GO annotation on QuickGO ...

    <p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

    Molecular functionHydrolase

    Enzyme and pathway databases

    BioCyc Collection of Pathway/Genome Databases

    More...    BioCyci    		MetaCyc:HS12255-MONOMER

    Pathway Commons web resource for biological pathway data

    More...    PathwayCommonsi    		Q9Y2H2

    Reactome - a knowledgebase of biological pathways and processes

    More...    Reactomei    		R-HSA-1660516, Synthesis of PIPs at the early endosome membrane

    SABIO-RK: Biochemical Reaction Kinetics Database

    More...    SABIO-RKi    		Q9Y2H2

    <p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

    <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
    Recommended name:
    Phosphatidylinositide phosphatase SAC2Curated (EC:3.1.3.252 Publications)
    Alternative name(s):
    Inositol polyphosphate 5-phosphatase FImported
    Sac domain-containing inositol phosphatase 2
    Sac domain-containing phosphoinositide 4-phosphatase 22 Publications
    Short name:
    hSAC2
    <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
    Name:INPP5FImported
    Synonyms:KIAA0966, SAC2
    ORF Names:MSTP007, MSTP047
    <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
    <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
    <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
    <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
    • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 10

    Organism-specific databases

    Eukaryotic Pathogen Database Resources

    More...    EuPathDBi    		HostDB:ENSG00000198825.11

    Human Gene Nomenclature Database

    More...    HGNCi    		HGNC:17054, INPP5F

    Online Mendelian Inheritance in Man (OMIM)

    More...    MIMi    		609389, gene

    neXtProt; the human protein knowledge platform

    More...    neXtProti    		NX_Q9Y2H2

    <p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

    Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

    Keywords - Cellular componenti

    Coated pit, Endosome, Membrane

    <p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

    Mutagenesis

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the <a href="http://www.uniprot.org/manual/pathology%5Fand%5Fbiotech%5Fsection">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi458C → S: Loss of inositol 4-phosphatase activity. Alters TFRC distribution and delays TF recycling. 1 Publication1

    Organism-specific databases

    DisGeNET

    More...    DisGeNETi    		22876

    Open Targets

    More...    OpenTargetsi    		ENSG00000198825

    The Pharmacogenetics and Pharmacogenomics Knowledge Base

    More...    PharmGKBi    		PA134927878

    Miscellaneous databases

    Pharos NIH Druggable Genome Knowledgebase

    More...    Pharosi    		Q9Y2H2, Tbio

    Polymorphism and mutation databases

    BioMuta curated single-nucleotide variation and disease association database

    More...    BioMutai    		INPP5F

    Domain mapping of disease mutations (DMDM)

    More...    DMDMi    		187611527

    <p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

    Molecule processing

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003316211 – 1132Phosphatidylinositide phosphatase SAC2Add BLAST1132

    Amino acid modifications

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei827PhosphoserineBy similarity1
    Modified residuei830PhosphoserineBy similarity1
    Modified residuei878PhosphoserineBy similarity1
    Modified residuei881PhosphoserineBy similarity1
    Modified residuei907PhosphoserineCombined sources1
    Modified residuei910PhosphoserineBy similarity1
    Modified residuei1103PhosphoserineCombined sources1

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    Encyclopedia of Proteome Dynamics

    More...    EPDi    		Q9Y2H2

    jPOST - Japan Proteome Standard Repository/Database

    More...    jPOSTi    		Q9Y2H2

    MassIVE - Mass Spectrometry Interactive Virtual Environment

    More...    MassIVEi    		Q9Y2H2

    PaxDb, a database of protein abundance averages across all three domains of life

    More...    PaxDbi    		Q9Y2H2

    PeptideAtlas

    More...    PeptideAtlasi    		Q9Y2H2

    PRoteomics IDEntifications database

    More...    PRIDEi    		Q9Y2H2

    ProteomicsDB: a multi-organism proteome resource

    More...    ProteomicsDBi    		65795
    85781 [Q9Y2H2-1]
    85782 [Q9Y2H2-2]
    85783 [Q9Y2H2-3]

    PTM databases

    DEPOD human dephosphorylation database

    More...    DEPODi    		INPP5F

    GlyGen: Computational and Informatics Resources for Glycoscience

    More...    GlyGeni    		Q9Y2H2, 1 site

    iPTMnet integrated resource for PTMs in systems biology context

    More...    iPTMneti    		Q9Y2H2

    Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

    More...    PhosphoSitePlusi    		Q9Y2H2

    SwissPalm database of S-palmitoylation events

    More...    SwissPalmi    		Q9Y2H2

    <p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

    <p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

    Ubiquitous (PubMed:11274189). Highly expressed in brain (PubMed:26203138).2 Publications

    Gene expression databases

    Bgee dataBase for Gene Expression Evolution

    More...    Bgeei    		ENSG00000198825, Expressed in pons and 238 other tissues

    ExpressionAtlas, Differential and Baseline Expression

    More...    ExpressionAtlasi    		Q9Y2H2, baseline and differential

    Genevisible search portal to normalized and curated expression data from Genevestigator

    More...    Genevisiblei    		Q9Y2H2, HS

    Organism-specific databases

    Human Protein Atlas

    More...    HPAi    		ENSG00000198825, Tissue enhanced (brain)

    <p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

    <p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

    Homodimer (PubMed:25869669).

    Interacts with OCRL and RAB5A (PubMed:25869668).

    Interacts with INPP5B and INPP4A (PubMed:25869668).

    Interacts with STAT3; the interaction is independent of STAT3 'TYR-705' phosphorylation status (PubMed:25476455).

    By similarity3 Publications

    GO - Molecular functioni

    Complete GO annotation on QuickGO ...

    Protein-protein interaction databases

    The Biological General Repository for Interaction Datasets (BioGRID)

    More...    BioGRIDi    		116543, 2 interactors

    The Eukaryotic Linear Motif resource for Functional Sites in Proteins

    More...    ELMi    		Q9Y2H2

    Protein interaction database and analysis system

    More...    IntActi    		Q9Y2H2, 1 interactor

    STRING: functional protein association networks

    More...    STRINGi    		9606.ENSP00000354519

    Miscellaneous databases

    RNAct, Protein-RNA interaction predictions for model organisms.

    More...    RNActi    		Q9Y2H2, protein

    <p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

    Secondary structure

    11132
    Legend: HelixTurnBeta strandPDB Structure known for this area
    Show more details

    3D structure databases

    SWISS-MODEL Repository - a database of annotated 3D protein structure models

    More...    SMRi    		Q9Y2H2

    Database of comparative protein structure models

    More...    ModBasei    		Search...

    Protein Data Bank in Europe - Knowledge Base

    More...    PDBe-KBi    		Search...

    <p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini167 – 518SACPROSITE-ProRule annotationAdd BLAST352
    Domaini593 – 760hSac2PROSITE-ProRule annotationAdd BLAST168

    Phylogenomic databases

    evolutionary genealogy of genes: Non-supervised Orthologous Groups

    More...    eggNOGi    		KOG1890, Eukaryota

    Ensembl GeneTree

    More...    GeneTreei    		ENSGT00940000155996

    The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

    More...    HOGENOMi    		CLU_008079_0_0_1

    InParanoid: Eukaryotic Ortholog Groups

    More...    InParanoidi    		Q9Y2H2

    KEGG Orthology (KO)

    More...    KOi    		K21798

    Identification of Orthologs from Complete Genome Data

    More...    OMAi    		DNCCLEL

    Database of Orthologous Groups

    More...    OrthoDBi    		359616at2759

    Database for complete collections of gene phylogenies

    More...    PhylomeDBi    		Q9Y2H2

    TreeFam database of animal gene trees

    More...    TreeFami    		TF313543

    Family and domain databases

    Integrated resource of protein families, domains and functional sites

    More...    InterProi    		View protein in InterPro
    IPR034753, hSac2
    IPR022158, Inositol_phosphatase
    IPR002013, SAC_dom

    Pfam protein domain database

    More...    Pfami    		View protein in Pfam
    PF12456, hSac2, 1 hit
    PF02383, Syja_N, 1 hit

    PROSITE; a protein domain and family database

    More...    PROSITEi    		View protein in PROSITE
    PS51791, HSAC2, 1 hit
    PS50275, SAC, 1 hit

    <p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (4+)i

    <p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

    This entry describes 4 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

    This entry has 4 described isoforms and 16 potential isoforms that are computationally mapped.Show allAlign All

    Isoform 1 (identifier: Q9Y2H2-1) [UniParc]FASTAAdd to basket

    This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide
            10         20         30         40         50
    MELFQAKDHY ILQQGERALW CSRRDGGLQL RPATDLLLAW NPICLGLVEG 
            60         70         80         90        100
    VIGKIQLHSD LPWWLILIRQ KALVGKLPGD HEVCKVTKIA VLSLSEMEPQ 
           110        120        130        140        150
    DLELELCKKH HFGINKPEKI IPSPDDSKFL LKTFTHIKSN VSAPNKKKVK 
           160        170        180        190        200
    ESKEKEKLER RLLEELLKMF MDSESFYYSL TYDLTNSVQR QSTGERDGRP 
           210        220        230        240        250
    LWQKVDDRFF WNKYMIQDLT EIGTPDVDFW IIPMIQGFVQ IEELVVNYTE 
           260        270        280        290        300
    SSDDEKSSPE TPPQESTCVD DIHPRFLVAL ISRRSRHRAG MRYKRRGVDK 
           310        320        330        340        350
    NGNVANYVET EQLIHVHNHT LSFVQTRGSV PVFWSQVGYR YNPRPRLDRS 
           360        370        380        390        400
    EKETVAYFCA HFEEQLNIYK KQVIINLVDQ AGREKIIGDA YLKQVLLFNN 
           410        420        430        440        450
    SHLTYVSFDF HEHCRGMKFE NVQTLTDAIY DIILDMKWCW VDEAGVICKQ 
           460        470        480        490        500
    EGIFRVNCMD CLDRTNVVQA AIARVVMEQQ LKKLGVMPPE QPLPVKCNRI 
           510        520        530        540        550
    YQIMWANNGD SISRQYAGTA ALKGDFTRTG ERKLAGVMKD GVNSANRYYL 
           560        570        580        590        600
    NRFKDAYRQA VIDLMQGIPV TEDLYSIFTK EKEHEALHKE NQRSHQELIS 
           610        620        630        640        650
    QLLQSYMKLL LPDDEKFHGG WALIDCDPSL IDATHRDVDV LLLLSNSAYY 
           660        670        680        690        700
    VAYYDDEVDK VNQYQRLSLE NLEKIEIGPE PTLFGKPKFS CMRLHYRYKE 
           710        720        730        740        750
    ASGYFHTLRA VMRNPEEDGK DTLQCIAEML QITKQAMGSD LPIIEKKLER 
           760        770        780        790        800
    KSSKPHEDII GIRSQNQGSL AQGKNFLMSK FSSLNQKVKQ TKSNVNIGNL 
           810        820        830        840        850
    RKLGNFTKPE MKVNFLKPNL KVNLWKSDSS LETMENTGVM DKVQAESDGD 
           860        870        880        890        900
    MSSDNDSYHS DEFLTNSKSD EDRQLANSLE SVGPIDYVLP SCGIIASAPR 
           910        920        930        940        950
    LGSRSQSLSS TDSSVHAPSE ITVAHGSGLG KGQESPLKKS PSAGDVHILT 
           960        970        980        990       1000
    GFAKPMDIYC HRFVQDAQNK VTHLSETRSV SQQASQERNQ MTNQVSNETQ 
          1010       1020       1030       1040       1050
    SESTEQTPSR PSQLDVSLSA TGPQFLSVEP AHSVASQKTP TSASSMLELE 
          1060       1070       1080       1090       1100
    TGLHVTPSPS ESSSSRAVSP FAKIRSSMVQ VASITQAGLT HGINFAVSKV 
          1110       1120       1130 
    QKSPPEPEII NQVQQNELKK MFIQCQTRII QI
    Length:1,132
    Mass (Da):128,407
    Last modified:April 29, 2008 - v3
    <p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i853719FC0AD455CD
    GO
    Isoform 2 (identifier: Q9Y2H2-2) [UniParc]FASTAAdd to basket

    The sequence of this isoform differs from the canonical sequence as follows:
         373-375: VII → QQK
         376-1132: Missing.

    Show »
    Length:375
    Mass (Da):43,817
    Checksum:iE9A76393F10C6CC3
    GO
    Isoform 3 (identifier: Q9Y2H2-3) [UniParc]FASTAAdd to basket

    The sequence of this isoform differs from the canonical sequence as follows:
         206-219: DDRFFWNKYMIQDL → PLTARRAGFALGKK
         220-1132: Missing.

    Show »
    Length:219
    Mass (Da):25,174
    Checksum:i8AAA498682414245
    GO
    Isoform 4 (identifier: Q9Y2H2-4) [UniParc]FASTAAdd to basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-19: MELFQAKDHYILQQGERAL → MCHDVIFMAWLKQQFSECT
         20-629: Missing.

    Show »
    Length:522
    Mass (Da):57,800
    Checksum:i8A15030B00C8E9A1
    GO

    <p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

    There are 16 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
    EntryEntry nameProtein names
    		Gene namesLengthAnnotation
    A0A3B3ITL0A0A3B3ITL0_HUMAN
    Phosphatidylinositide phosphatase S...
    INPP5F
    		1,036Annotation score:

    Annotation score:1 out of 5

    <p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
    A0A3B3IRJ9A0A3B3IRJ9_HUMAN
    Phosphatidylinositide phosphatase S...
    INPP5F
    		1,070Annotation score:

    Annotation score:1 out of 5

    <p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
    A0A0J9YYL5A0A0J9YYL5_HUMAN
    Phosphatidylinositide phosphatase S...
    INPP5F
    		82Annotation score:

    Annotation score:1 out of 5

    <p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
    A0A3B3ISI3A0A3B3ISI3_HUMAN
    Phosphatidylinositide phosphatase S...
    INPP5F
    		747Annotation score:

    Annotation score:1 out of 5

    <p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
    A0A3B3ITR9A0A3B3ITR9_HUMAN
    Phosphatidylinositide phosphatase S...
    INPP5F
    		646Annotation score:

    Annotation score:1 out of 5

    <p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
    A0A3B3ISJ5A0A3B3ISJ5_HUMAN
    Phosphatidylinositide phosphatase S...
    INPP5F
    		460Annotation score:

    Annotation score:1 out of 5

    <p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
    A0A3B3ISK0A0A3B3ISK0_HUMAN
    Phosphatidylinositide phosphatase S...
    INPP5F
    		120Annotation score:

    Annotation score:1 out of 5

    <p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
    A0A0J9YY79A0A0J9YY79_HUMAN
    Phosphatidylinositide phosphatase S...
    INPP5F
    		183Annotation score:

    Annotation score:1 out of 5

    <p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
    A0A0J9YVW6A0A0J9YVW6_HUMAN
    Phosphatidylinositide phosphatase S...
    INPP5F
    		57Annotation score:

    Annotation score:1 out of 5

    <p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
    A0A0J9YWP2A0A0J9YWP2_HUMAN
    Phosphatidylinositide phosphatase S...
    INPP5F
    		105Annotation score:

    Annotation score:1 out of 5

    <p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
    There are more potential isoformsShow all

    <p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

    The sequence BAA76810 differs from that shown. Reason: Erroneous initiation. Extended N-terminus.Curated

    Experimental Info

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti386I → V in AAI11494 (PubMed:15489334).Curated1
    Sequence conflicti654Y → N in BAG52363 (PubMed:14702039).Curated1
    Sequence conflicti1008P → L in BAG52363 (PubMed:14702039).Curated1
    Sequence conflicti1019S → P in BAG52363 (PubMed:14702039).Curated1

    Natural variant

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_042907453I → V. Corresponds to variant dbSNP:rs3736822Ensembl.1
    Natural variantiVAR_042908997N → D2 PublicationsCorresponds to variant dbSNP:rs3188055Ensembl.1

    Alternative sequence

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0463661 – 19MELFQ…GERAL → MCHDVIFMAWLKQQFSECT in isoform 4. 1 PublicationAdd BLAST19
    Alternative sequenceiVSP_04636720 – 629Missing in isoform 4. 1 PublicationAdd BLAST610
    Alternative sequenceiVSP_033266206 – 219DDRFF…MIQDL → PLTARRAGFALGKK in isoform 3. 1 PublicationAdd BLAST14
    Alternative sequenceiVSP_033267220 – 1132Missing in isoform 3. 1 PublicationAdd BLAST913
    Alternative sequenceiVSP_033268373 – 375VII → QQK in isoform 2. 1 Publication3
    Alternative sequenceiVSP_033269376 – 1132Missing in isoform 2. 1 PublicationAdd BLAST757

    Sequence databases

    Select the link destinations:

    EMBL nucleotide sequence database

    More...    EMBLi

    GenBank nucleotide sequence database

    More...    GenBanki

    DNA Data Bank of Japan; a nucleotide sequence database

    More...    DDBJi
    Links Updated
    		AB023183 mRNA Translation: BAA76810.2 Different initiation.
    AK091448 mRNA Translation: BAG52363.1
    AC027672 Genomic DNA No translation available.
    AL133461 Genomic DNA No translation available.
    AL158014 Genomic DNA No translation available.
    CH471066 Genomic DNA Translation: EAW49379.1
    CH471066 Genomic DNA Translation: EAW49380.1
    CH471066 Genomic DNA Translation: EAW49381.1
    BC052367 mRNA Translation: AAH52367.1
    BC067820 mRNA Translation: AAH67820.1
    BC082755 mRNA Translation: AAH82755.1
    BC111493 mRNA Translation: AAI11494.1
    AL137528 mRNA Translation: CAB70792.1
    AF113227 mRNA Translation: AAG39298.1
    AF109361 mRNA Translation: AAQ13509.1

    The Consensus CDS (CCDS) project

    More...    CCDSi    		CCDS58098.1 [Q9Y2H2-4]
    CCDS7616.1 [Q9Y2H2-1]
    CCDS81513.1 [Q9Y2H2-3]

    Protein sequence database of the Protein Information Resource

    More...    PIRi    		T46372

    NCBI Reference Sequences

    More...    RefSeqi    		NP_001230123.1, NM_001243194.1 [Q9Y2H2-4]
    NP_001230124.1, NM_001243195.1 [Q9Y2H2-3]
    NP_055752.1, NM_014937.3 [Q9Y2H2-1]

    Genome annotation databases

    Ensembl eukaryotic genome annotation project

    More...    Ensembli    		ENST00000369081; ENSP00000489864; ENSG00000198825 [Q9Y2H2-3]
    ENST00000650409; ENSP00000496955; ENSG00000198825 [Q9Y2H2-4]
    ENST00000650623; ENSP00000497527; ENSG00000198825 [Q9Y2H2-1]

    Database of genes from NCBI RefSeq genomes

    More...    GeneIDi    		22876

    KEGG: Kyoto Encyclopedia of Genes and Genomes

    More...    KEGGi    		hsa:22876

    UCSC genome browser

    More...    UCSCi    		uc001leo.4, human [Q9Y2H2-1]

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    <p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

    <p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBLi
    GenBanki
    DDBJi
    Links Updated
    		AB023183 mRNA Translation: BAA76810.2 Different initiation.
    AK091448 mRNA Translation: BAG52363.1
    AC027672 Genomic DNA No translation available.
    AL133461 Genomic DNA No translation available.
    AL158014 Genomic DNA No translation available.
    CH471066 Genomic DNA Translation: EAW49379.1
    CH471066 Genomic DNA Translation: EAW49380.1
    CH471066 Genomic DNA Translation: EAW49381.1
    BC052367 mRNA Translation: AAH52367.1
    BC067820 mRNA Translation: AAH67820.1
    BC082755 mRNA Translation: AAH82755.1
    BC111493 mRNA Translation: AAI11494.1
    AL137528 mRNA Translation: CAB70792.1
    AF113227 mRNA Translation: AAG39298.1
    AF109361 mRNA Translation: AAQ13509.1
    CCDSiCCDS58098.1 [Q9Y2H2-4]
    CCDS7616.1 [Q9Y2H2-1]
    CCDS81513.1 [Q9Y2H2-3]
    PIRiT46372
    RefSeqiNP_001230123.1, NM_001243194.1 [Q9Y2H2-4]
    NP_001230124.1, NM_001243195.1 [Q9Y2H2-3]
    NP_055752.1, NM_014937.3 [Q9Y2H2-1]

    3D structure databases

    Select the link destinations:

    Protein Data Bank Europe

    More...    PDBei

    Protein Data Bank RCSB

    More...    RCSB PDBi

    Protein Data Bank Japan

    More...    PDBji
    Links Updated
    		PDB entryMethodResolution (Å)ChainPositionsPDBsum
    4XUUX-ray2.62A/B/C/D593-760[»]
    SMRiQ9Y2H2
    ModBaseiSearch...
    PDBe-KBiSearch...

    Protein-protein interaction databases

    BioGRIDi116543, 2 interactors
    ELMiQ9Y2H2
    IntActiQ9Y2H2, 1 interactor
    STRINGi9606.ENSP00000354519

    PTM databases

    DEPODiINPP5F
    GlyGeniQ9Y2H2, 1 site
    iPTMnetiQ9Y2H2
    PhosphoSitePlusiQ9Y2H2
    SwissPalmiQ9Y2H2

    Polymorphism and mutation databases

    BioMutaiINPP5F
    DMDMi187611527

    Proteomic databases

    EPDiQ9Y2H2
    jPOSTiQ9Y2H2
    MassIVEiQ9Y2H2
    PaxDbiQ9Y2H2
    PeptideAtlasiQ9Y2H2
    PRIDEiQ9Y2H2
    ProteomicsDBi65795
    85781 [Q9Y2H2-1]
    85782 [Q9Y2H2-2]
    85783 [Q9Y2H2-3]

    Protocols and materials databases

    Antibodypedia a portal for validated antibodies

    More...    Antibodypediai    		32161, 88 antibodies

    Genome annotation databases

    EnsembliENST00000369081; ENSP00000489864; ENSG00000198825 [Q9Y2H2-3]
    ENST00000650409; ENSP00000496955; ENSG00000198825 [Q9Y2H2-4]
    ENST00000650623; ENSP00000497527; ENSG00000198825 [Q9Y2H2-1]
    GeneIDi22876
    KEGGihsa:22876
    UCSCiuc001leo.4, human [Q9Y2H2-1]

    Organism-specific databases

    Comparative Toxicogenomics Database

    More...    CTDi    		22876
    DisGeNETi22876
    EuPathDBiHostDB:ENSG00000198825.11

    GeneCards: human genes, protein and diseases

    More...    GeneCardsi    		INPP5F
    HGNCiHGNC:17054, INPP5F
    HPAiENSG00000198825, Tissue enhanced (brain)
    MIMi609389, gene
    neXtProtiNX_Q9Y2H2
    OpenTargetsiENSG00000198825
    PharmGKBiPA134927878

    Human Unidentified Gene-Encoded large proteins database

    More...    HUGEi    		Search...

    GenAtlas: human gene database

    More...    GenAtlasi    		Search...

    Phylogenomic databases

    eggNOGiKOG1890, Eukaryota
    GeneTreeiENSGT00940000155996
    HOGENOMiCLU_008079_0_0_1
    InParanoidiQ9Y2H2
    KOiK21798
    OMAiDNCCLEL
    OrthoDBi359616at2759
    PhylomeDBiQ9Y2H2
    TreeFamiTF313543

    Enzyme and pathway databases

    BioCyciMetaCyc:HS12255-MONOMER
    PathwayCommonsiQ9Y2H2
    ReactomeiR-HSA-1660516, Synthesis of PIPs at the early endosome membrane
    SABIO-RKiQ9Y2H2

    Miscellaneous databases

    BioGRID ORCS database of CRISPR phenotype screens

    More...    BioGRID-ORCSi    		22876, 10 hits in 867 CRISPR screens

    ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

    More...    ChiTaRSi    		INPP5F, human

    Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

    More...    GenomeRNAii    		22876
    PharosiQ9Y2H2, Tbio

    Protein Ontology

    More...    PROi    		PR:Q9Y2H2
    RNActiQ9Y2H2, protein

    The Stanford Online Universal Resource for Clones and ESTs

    More...    SOURCEi    		Search...

    Gene expression databases

    BgeeiENSG00000198825, Expressed in pons and 238 other tissues
    ExpressionAtlasiQ9Y2H2, baseline and differential
    GenevisibleiQ9Y2H2, HS

    Family and domain databases

    InterProiView protein in InterPro
    IPR034753, hSac2
    IPR022158, Inositol_phosphatase
    IPR002013, SAC_dom
    PfamiView protein in Pfam
    PF12456, hSac2, 1 hit
    PF02383, Syja_N, 1 hit
    PROSITEiView protein in PROSITE
    PS51791, HSAC2, 1 hit
    PS50275, SAC, 1 hit

    ProtoNet; Automatic hierarchical classification of proteins

    More...    ProtoNeti    		Search...

    MobiDB: a database of protein disorder and mobility annotations

    More...    MobiDBi    		Search...

    <p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

    <p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiSAC2_HUMAN
    <p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9Y2H2
    Secondary accession number(s): B3KRF1
    , D3DRD1, Q2T9J4, Q5W135, Q5W136, Q6NVY2, Q86U97, Q9H3D9, Q9NT51
    <p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 29, 2008
    Last sequence update: April 29, 2008
    Last modified: August 12, 2020
    This is version 140 of the entry and version 3 of the sequence. See complete history.
    <p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    <p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

    Keywords - Technical termi

    3D-structure, Reference proteome

    Documents

    1. Human chromosome 10
      Human chromosome 10: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    UniProt is an ELIXIR core data resource
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