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Entry version 146 (23 Feb 2022)
Sequence version 3 (29 Apr 2008)
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Protein

Phosphatidylinositide phosphatase SAC2

Gene

INPP5F

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Inositol 4-phosphatase which mainly acts on phosphatidylinositol 4-phosphate. May be functionally linked to OCRL, which converts phosphatidylinositol 4,5-bisphosphate to phosphatidylinositol, for a sequential dephosphorylation of phosphatidylinositol 4,5-bisphosphate at the 5 and 4 position of inositol, thus playing an important role in the endocytic recycling (PubMed:25869669).

Regulator of TF:TFRC and integrins recycling pathway, is also involved in cell migration mechanisms (PubMed:25869669).

Modulates AKT/GSK3B pathway by decreasing AKT and GSK3B phosphorylation (PubMed:17322895).

Negatively regulates STAT3 signaling pathway through inhibition of STAT3 phosphorylation and translocation to the nucleus (PubMed:25476455).

Functionally important modulator of cardiac myocyte size and of the cardiac response to stress (By similarity).

May play a role as negative regulator of axon regeneration after central nervous system injuries (By similarity).

By similarity3 Publications

Caution

INPP5F has been initially described as an inositol polyphosphate 5-phosphatase.1 Publication

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the 'Function' section describes biophysical and chemical properties, such as maximal absorption, kinetic parameters, pH dependence, redox potentials and temperature dependence.<p><a href='/help/biophysicochemical_properties' target='_top'>More...</a></p>Kineticsi

  1. KM=14.3 µM for PtdIns(4,5)P2 (at pH 6.0)1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionHydrolase

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...
PathwayCommonsi
Q9Y2H2

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-1660516, Synthesis of PIPs at the early endosome membrane

SABIO-RK: Biochemical Reaction Kinetics Database

More...
SABIO-RKi
Q9Y2H2

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...
SignaLinki
Q9Y2H2

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Phosphatidylinositide phosphatase SAC2Curated (EC:3.1.3.252 Publications)
Alternative name(s):
Inositol polyphosphate 5-phosphatase FImported
Sac domain-containing inositol phosphatase 2
Sac domain-containing phosphoinositide 4-phosphatase 22 Publications
Short name:
hSAC2
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:INPP5FImported
Synonyms:KIAA0966, SAC2
ORF Names:MSTP007, MSTP047
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 10

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:17054, INPP5F

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
609389, gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q9Y2H2

Eukaryotic Pathogen, Vector and Host Database Resources

More...
VEuPathDBi
HostDB:ENSG00000198825

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Coated pit, Endosome, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology%5Fand%5Fbiotech%5Fsection">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi458C → S: Loss of inositol 4-phosphatase activity. Alters TFRC distribution and delays TF recycling. 1 Publication1

Organism-specific databases

DisGeNET

More...
DisGeNETi
22876

Open Targets

More...
OpenTargetsi
ENSG00000198825

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA134927878

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q9Y2H2, Tbio

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
INPP5F

Domain mapping of disease mutations (DMDM)

More...
DMDMi
187611527

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003316211 – 1132Phosphatidylinositide phosphatase SAC2Add BLAST1132

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei827PhosphoserineBy similarity1
Modified residuei830PhosphoserineBy similarity1
Modified residuei878PhosphoserineBy similarity1
Modified residuei881PhosphoserineBy similarity1
Modified residuei907PhosphoserineCombined sources1
Modified residuei910PhosphoserineBy similarity1
Modified residuei1103PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q9Y2H2

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q9Y2H2

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
Q9Y2H2

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q9Y2H2

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q9Y2H2

PeptideAtlas

More...
PeptideAtlasi
Q9Y2H2

PRoteomics IDEntifications database

More...
PRIDEi
Q9Y2H2

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
65795
85781 [Q9Y2H2-1]
85782 [Q9Y2H2-2]
85783 [Q9Y2H2-3]

PTM databases

DEPOD human dephosphorylation database

More...
DEPODi
INPP5F

GlyGen: Computational and Informatics Resources for Glycoscience

More...
GlyGeni
Q9Y2H2, 2 sites, 1 O-linked glycan (1 site)

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q9Y2H2

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q9Y2H2

SwissPalm database of S-palmitoylation events

More...
SwissPalmi
Q9Y2H2

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Ubiquitous (PubMed:11274189). Highly expressed in brain (PubMed:26203138).2 Publications

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000198825, Expressed in pons and 239 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q9Y2H2, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q9Y2H2, HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
ENSG00000198825, Tissue enhanced (brain)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Homodimer (PubMed:25869669).

Interacts with OCRL and RAB5A (PubMed:25869668).

Interacts with INPP5B and INPP4A (PubMed:25869668).

Interacts with STAT3; the interaction is independent of STAT3 'TYR-705' phosphorylation status (PubMed:25476455).

By similarity3 Publications

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
116543, 20 interactors

The Eukaryotic Linear Motif resource for Functional Sites in Proteins

More...
ELMi
Q9Y2H2

Protein interaction database and analysis system

More...
IntActi
Q9Y2H2, 2 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000354519

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q9Y2H2, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

11132
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q9Y2H2

Database of comparative protein structure models

More...
ModBasei
Search...

Protein Data Bank in Europe - Knowledge Base

More...
PDBe-KBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini167 – 518SACPROSITE-ProRule annotationAdd BLAST352
Domaini593 – 760hSac2PROSITE-ProRule annotationAdd BLAST168

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni846 – 875DisorderedSequence analysisAdd BLAST30
Regioni923 – 942DisorderedSequence analysisAdd BLAST20
Regioni974 – 1017DisorderedSequence analysisAdd BLAST44

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi847 – 875Basic and acidic residuesSequence analysisAdd BLAST29

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1890, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000155996

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_008079_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q9Y2H2

Identification of Orthologs from Complete Genome Data

More...
OMAi
DNCCLEL

Database of Orthologous Groups

More...
OrthoDBi
359616at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q9Y2H2

TreeFam database of animal gene trees

More...
TreeFami
TF313543

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR034753, hSac2
IPR022158, Inositol_phosphatase
IPR002013, SAC_dom

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF12456, hSac2, 1 hit
PF02383, Syja_N, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51791, HSAC2, 1 hit
PS50275, SAC, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (4+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 4 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 4 described isoforms and 16 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q9Y2H2-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <p><strong>What is the canonical sequence?</strong><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MELFQAKDHY ILQQGERALW CSRRDGGLQL RPATDLLLAW NPICLGLVEG
60 70 80 90 100
VIGKIQLHSD LPWWLILIRQ KALVGKLPGD HEVCKVTKIA VLSLSEMEPQ
110 120 130 140 150
DLELELCKKH HFGINKPEKI IPSPDDSKFL LKTFTHIKSN VSAPNKKKVK
160 170 180 190 200
ESKEKEKLER RLLEELLKMF MDSESFYYSL TYDLTNSVQR QSTGERDGRP
210 220 230 240 250
LWQKVDDRFF WNKYMIQDLT EIGTPDVDFW IIPMIQGFVQ IEELVVNYTE
260 270 280 290 300
SSDDEKSSPE TPPQESTCVD DIHPRFLVAL ISRRSRHRAG MRYKRRGVDK
310 320 330 340 350
NGNVANYVET EQLIHVHNHT LSFVQTRGSV PVFWSQVGYR YNPRPRLDRS
360 370 380 390 400
EKETVAYFCA HFEEQLNIYK KQVIINLVDQ AGREKIIGDA YLKQVLLFNN
410 420 430 440 450
SHLTYVSFDF HEHCRGMKFE NVQTLTDAIY DIILDMKWCW VDEAGVICKQ
460 470 480 490 500
EGIFRVNCMD CLDRTNVVQA AIARVVMEQQ LKKLGVMPPE QPLPVKCNRI
510 520 530 540 550
YQIMWANNGD SISRQYAGTA ALKGDFTRTG ERKLAGVMKD GVNSANRYYL
560 570 580 590 600
NRFKDAYRQA VIDLMQGIPV TEDLYSIFTK EKEHEALHKE NQRSHQELIS
610 620 630 640 650
QLLQSYMKLL LPDDEKFHGG WALIDCDPSL IDATHRDVDV LLLLSNSAYY
660 670 680 690 700
VAYYDDEVDK VNQYQRLSLE NLEKIEIGPE PTLFGKPKFS CMRLHYRYKE
710 720 730 740 750
ASGYFHTLRA VMRNPEEDGK DTLQCIAEML QITKQAMGSD LPIIEKKLER
760 770 780 790 800
KSSKPHEDII GIRSQNQGSL AQGKNFLMSK FSSLNQKVKQ TKSNVNIGNL
810 820 830 840 850
RKLGNFTKPE MKVNFLKPNL KVNLWKSDSS LETMENTGVM DKVQAESDGD
860 870 880 890 900
MSSDNDSYHS DEFLTNSKSD EDRQLANSLE SVGPIDYVLP SCGIIASAPR
910 920 930 940 950
LGSRSQSLSS TDSSVHAPSE ITVAHGSGLG KGQESPLKKS PSAGDVHILT
960 970 980 990 1000
GFAKPMDIYC HRFVQDAQNK VTHLSETRSV SQQASQERNQ MTNQVSNETQ
1010 1020 1030 1040 1050
SESTEQTPSR PSQLDVSLSA TGPQFLSVEP AHSVASQKTP TSASSMLELE
1060 1070 1080 1090 1100
TGLHVTPSPS ESSSSRAVSP FAKIRSSMVQ VASITQAGLT HGINFAVSKV
1110 1120 1130
QKSPPEPEII NQVQQNELKK MFIQCQTRII QI
Length:1,132
Mass (Da):128,407
Last modified:April 29, 2008 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i853719FC0AD455CD
GO
Isoform 2 (identifier: Q9Y2H2-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     373-375: VII → QQK
     376-1132: Missing.

Show »
Length:375
Mass (Da):43,817
Checksum:iE9A76393F10C6CC3
GO
Isoform 3 (identifier: Q9Y2H2-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     206-219: DDRFFWNKYMIQDL → PLTARRAGFALGKK
     220-1132: Missing.

Show »
Length:219
Mass (Da):25,174
Checksum:i8AAA498682414245
GO
Isoform 4 (identifier: Q9Y2H2-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-19: MELFQAKDHYILQQGERAL → MCHDVIFMAWLKQQFSECT
     20-629: Missing.

Show »
Length:522
Mass (Da):57,800
Checksum:i8A15030B00C8E9A1
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 16 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A3B3ITL0A0A3B3ITL0_HUMAN
Phosphatidylinositide phosphatase S...
INPP5F
1,036Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A3B3IRJ9A0A3B3IRJ9_HUMAN
Phosphatidylinositide phosphatase S...
INPP5F
1,070Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0J9YY79A0A0J9YY79_HUMAN
Phosphatidylinositide phosphatase S...
INPP5F
183Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0J9YYL5A0A0J9YYL5_HUMAN
Phosphatidylinositide phosphatase S...
INPP5F
82Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A3B3ITR9A0A3B3ITR9_HUMAN
Phosphatidylinositide phosphatase S...
INPP5F
646Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A3B3ISI3A0A3B3ISI3_HUMAN
Phosphatidylinositide phosphatase S...
INPP5F
747Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A3B3ISJ5A0A3B3ISJ5_HUMAN
Phosphatidylinositide phosphatase S...
INPP5F
460Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A3B3ISK0A0A3B3ISK0_HUMAN
Phosphatidylinositide phosphatase S...
INPP5F
120Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0J9YVW6A0A0J9YVW6_HUMAN
Phosphatidylinositide phosphatase S...
INPP5F
57Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0J9YWP2A0A0J9YWP2_HUMAN
Phosphatidylinositide phosphatase S...
INPP5F
105Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
There are more potential isoformsShow all

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence BAA76810 differs from that shown. Reason: Erroneous initiation. Extended N-terminus.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti386I → V in AAI11494 (PubMed:15489334).Curated1
Sequence conflicti654Y → N in BAG52363 (PubMed:14702039).Curated1
Sequence conflicti1008P → L in BAG52363 (PubMed:14702039).Curated1
Sequence conflicti1019S → P in BAG52363 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_042907453I → V. Corresponds to variant dbSNP:rs3736822Ensembl.1
Natural variantiVAR_042908997N → D2 PublicationsCorresponds to variant dbSNP:rs3188055Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0463661 – 19MELFQ…GERAL → MCHDVIFMAWLKQQFSECT in isoform 4. 1 PublicationAdd BLAST19
Alternative sequenceiVSP_04636720 – 629Missing in isoform 4. 1 PublicationAdd BLAST610
Alternative sequenceiVSP_033266206 – 219DDRFF…MIQDL → PLTARRAGFALGKK in isoform 3. 1 PublicationAdd BLAST14
Alternative sequenceiVSP_033267220 – 1132Missing in isoform 3. 1 PublicationAdd BLAST913
Alternative sequenceiVSP_033268373 – 375VII → QQK in isoform 2. 1 Publication3
Alternative sequenceiVSP_033269376 – 1132Missing in isoform 2. 1 PublicationAdd BLAST757

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AB023183 mRNA Translation: BAA76810.2 Different initiation.
AK091448 mRNA Translation: BAG52363.1
AC027672 Genomic DNA No translation available.
AL133461 Genomic DNA No translation available.
AL158014 Genomic DNA No translation available.
CH471066 Genomic DNA Translation: EAW49379.1
CH471066 Genomic DNA Translation: EAW49380.1
CH471066 Genomic DNA Translation: EAW49381.1
BC052367 mRNA Translation: AAH52367.1
BC067820 mRNA Translation: AAH67820.1
BC082755 mRNA Translation: AAH82755.1
BC111493 mRNA Translation: AAI11494.1
AL137528 mRNA Translation: CAB70792.1
AF113227 mRNA Translation: AAG39298.1
AF109361 mRNA Translation: AAQ13509.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS58098.1 [Q9Y2H2-4]
CCDS7616.1 [Q9Y2H2-1]
CCDS81513.1 [Q9Y2H2-3]

Protein sequence database of the Protein Information Resource

More...
PIRi
T46372

NCBI Reference Sequences

More...
RefSeqi
NP_001230123.1, NM_001243194.1 [Q9Y2H2-4]
NP_001230124.1, NM_001243195.1 [Q9Y2H2-3]
NP_055752.1, NM_014937.3 [Q9Y2H2-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000369081; ENSP00000489864; ENSG00000198825 [Q9Y2H2-3]
ENST00000650409; ENSP00000496955; ENSG00000198825 [Q9Y2H2-4]
ENST00000650623; ENSP00000497527; ENSG00000198825

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
22876

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:22876

Matched Annotation from NCBI and EMBL-EBI (MANE) - Phase one

More...
MANE-Selecti
ENST00000650623.2; ENSP00000497527.1; NM_014937.4; NP_055752.1

UCSC genome browser

More...
UCSCi
uc001leo.4, human [Q9Y2H2-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB023183 mRNA Translation: BAA76810.2 Different initiation.
AK091448 mRNA Translation: BAG52363.1
AC027672 Genomic DNA No translation available.
AL133461 Genomic DNA No translation available.
AL158014 Genomic DNA No translation available.
CH471066 Genomic DNA Translation: EAW49379.1
CH471066 Genomic DNA Translation: EAW49380.1
CH471066 Genomic DNA Translation: EAW49381.1
BC052367 mRNA Translation: AAH52367.1
BC067820 mRNA Translation: AAH67820.1
BC082755 mRNA Translation: AAH82755.1
BC111493 mRNA Translation: AAI11494.1
AL137528 mRNA Translation: CAB70792.1
AF113227 mRNA Translation: AAG39298.1
AF109361 mRNA Translation: AAQ13509.1
CCDSiCCDS58098.1 [Q9Y2H2-4]
CCDS7616.1 [Q9Y2H2-1]
CCDS81513.1 [Q9Y2H2-3]
PIRiT46372
RefSeqiNP_001230123.1, NM_001243194.1 [Q9Y2H2-4]
NP_001230124.1, NM_001243195.1 [Q9Y2H2-3]
NP_055752.1, NM_014937.3 [Q9Y2H2-1]

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...
PDBei

Protein Data Bank RCSB

More...
RCSB PDBi

Protein Data Bank Japan

More...
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4XUUX-ray2.62A/B/C/D593-760[»]
SMRiQ9Y2H2
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi116543, 20 interactors
ELMiQ9Y2H2
IntActiQ9Y2H2, 2 interactors
STRINGi9606.ENSP00000354519

PTM databases

DEPODiINPP5F
GlyGeniQ9Y2H2, 2 sites, 1 O-linked glycan (1 site)
iPTMnetiQ9Y2H2
PhosphoSitePlusiQ9Y2H2
SwissPalmiQ9Y2H2

Genetic variation databases

BioMutaiINPP5F
DMDMi187611527

Proteomic databases

EPDiQ9Y2H2
jPOSTiQ9Y2H2
MassIVEiQ9Y2H2
MaxQBiQ9Y2H2
PaxDbiQ9Y2H2
PeptideAtlasiQ9Y2H2
PRIDEiQ9Y2H2
ProteomicsDBi65795
85781 [Q9Y2H2-1]
85782 [Q9Y2H2-2]
85783 [Q9Y2H2-3]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...
Antibodypediai
32161, 97 antibodies from 18 providers

The DNASU plasmid repository

More...
DNASUi
22876

Genome annotation databases

EnsembliENST00000369081; ENSP00000489864; ENSG00000198825 [Q9Y2H2-3]
ENST00000650409; ENSP00000496955; ENSG00000198825 [Q9Y2H2-4]
ENST00000650623; ENSP00000497527; ENSG00000198825
GeneIDi22876
KEGGihsa:22876
MANE-SelectiENST00000650623.2; ENSP00000497527.1; NM_014937.4; NP_055752.1
UCSCiuc001leo.4, human [Q9Y2H2-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
22876
DisGeNETi22876

GeneCards: human genes, protein and diseases

More...
GeneCardsi
INPP5F
HGNCiHGNC:17054, INPP5F
HPAiENSG00000198825, Tissue enhanced (brain)
MIMi609389, gene
neXtProtiNX_Q9Y2H2
OpenTargetsiENSG00000198825
PharmGKBiPA134927878
VEuPathDBiHostDB:ENSG00000198825

Human Unidentified Gene-Encoded large proteins database

More...
HUGEi
Search...

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG1890, Eukaryota
GeneTreeiENSGT00940000155996
HOGENOMiCLU_008079_0_0_1
InParanoidiQ9Y2H2
OMAiDNCCLEL
OrthoDBi359616at2759
PhylomeDBiQ9Y2H2
TreeFamiTF313543

Enzyme and pathway databases

PathwayCommonsiQ9Y2H2
ReactomeiR-HSA-1660516, Synthesis of PIPs at the early endosome membrane
SABIO-RKiQ9Y2H2
SignaLinkiQ9Y2H2

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...
BioGRID-ORCSi
22876, 12 hits in 1040 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
INPP5F, human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
22876
PharosiQ9Y2H2, Tbio

Protein Ontology

More...
PROi
PR:Q9Y2H2
RNActiQ9Y2H2, protein

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000198825, Expressed in pons and 239 other tissues
ExpressionAtlasiQ9Y2H2, baseline and differential
GenevisibleiQ9Y2H2, HS

Family and domain databases

InterProiView protein in InterPro
IPR034753, hSac2
IPR022158, Inositol_phosphatase
IPR002013, SAC_dom
PfamiView protein in Pfam
PF12456, hSac2, 1 hit
PF02383, Syja_N, 1 hit
PROSITEiView protein in PROSITE
PS51791, HSAC2, 1 hit
PS50275, SAC, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiSAC2_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9Y2H2
Secondary accession number(s): B3KRF1
, D3DRD1, Q2T9J4, Q5W135, Q5W136, Q6NVY2, Q86U97, Q9H3D9, Q9NT51
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 29, 2008
Last sequence update: April 29, 2008
Last modified: February 23, 2022
This is version 146 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Reference proteome

Documents

  1. Human chromosome 10
    Human chromosome 10: entries, gene names and cross-references to MIM
  2. Human entries with genetic variants
    List of human entries with genetic variants
  3. Human variants curated from literature reports
    Index of human variants curated from literature reports
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
UniProt is an ELIXIR core data resource
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