UniProtKB - Q9Y2H2 (SAC2_HUMAN)
Phosphatidylinositide phosphatase SAC2
INPP5F
Functioni
Inositol 4-phosphatase which mainly acts on phosphatidylinositol 4-phosphate. May be functionally linked to OCRL, which converts phosphatidylinositol 4,5-bisphosphate to phosphatidylinositol, for a sequential dephosphorylation of phosphatidylinositol 4,5-bisphosphate at the 5 and 4 position of inositol, thus playing an important role in the endocytic recycling (PubMed:25869669).
Regulator of TF:TFRC and integrins recycling pathway, is also involved in cell migration mechanisms (PubMed:25869669).
Modulates AKT/GSK3B pathway by decreasing AKT and GSK3B phosphorylation (PubMed:17322895).
Negatively regulates STAT3 signaling pathway through inhibition of STAT3 phosphorylation and translocation to the nucleus (PubMed:25476455).
Functionally important modulator of cardiac myocyte size and of the cardiac response to stress (By similarity).
May play a role as negative regulator of axon regeneration after central nervous system injuries (By similarity).
By similarity3 PublicationsCaution
Catalytic activityi
- EC:3.1.3.252 Publications
Kineticsi
- KM=14.3 µM for PtdIns(4,5)P2 (at pH 6.0)1 Publication
GO - Molecular functioni
- inositol monophosphate 1-phosphatase activity Source: UniProtKB-EC
- inositol monophosphate 3-phosphatase activity Source: UniProtKB-EC
- inositol monophosphate 4-phosphatase activity Source: UniProtKB-EC
- phosphatidylinositol-4-phosphate phosphatase activity Source: GO_Central
- phosphatidylinositol phosphate 4-phosphatase activity Source: ParkinsonsUK-UCL
- phosphatidylinositol phosphate 5-phosphatase activity Source: ParkinsonsUK-UCL
- protein homodimerization activity Source: UniProtKB
GO - Biological processi
- adult locomotory behavior Source: Ensembl
- cardiac muscle hypertrophy in response to stress Source: UniProtKB
- clathrin-dependent endocytosis Source: UniProtKB
- negative regulation of axon regeneration Source: BHF-UCL
- negative regulation of peptidyl-serine phosphorylation Source: Ensembl
- negative regulation of tyrosine phosphorylation of STAT protein Source: UniProtKB
- phosphatidylinositol biosynthetic process Source: Reactome
- phosphatidylinositol catabolic process Source: UniProtKB
- phosphatidylinositol dephosphorylation Source: ParkinsonsUK-UCL
- phosphatidylinositol-mediated signaling Source: UniProtKB
- positive regulation of receptor recycling Source: ParkinsonsUK-UCL
- regulation of cell motility Source: UniProtKB
- regulation of endocytic recycling Source: UniProtKB
- regulation of protein kinase B signaling Source: Ensembl
Keywordsi
Molecular function | Hydrolase |
Enzyme and pathway databases
PathwayCommonsi | Q9Y2H2 |
Reactomei | R-HSA-1660516, Synthesis of PIPs at the early endosome membrane |
SABIO-RKi | Q9Y2H2 |
SignaLinki | Q9Y2H2 |
Names & Taxonomyi
Protein namesi | Recommended name: Phosphatidylinositide phosphatase SAC2Curated (EC:3.1.3.252 Publications)Alternative name(s): Inositol polyphosphate 5-phosphatase FImported Sac domain-containing inositol phosphatase 2 Sac domain-containing phosphoinositide 4-phosphatase 22 Publications Short name: hSAC2 |
Gene namesi | ORF Names:MSTP007, MSTP047 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:17054, INPP5F |
MIMi | 609389, gene |
neXtProti | NX_Q9Y2H2 |
VEuPathDBi | HostDB:ENSG00000198825 |
Subcellular locationi
Endosome
- Early endosome 1 Publication
- Recycling endosome 1 Publication
Other locations
- clathrin-coated pit 1 Publication
Note: Also found on macropinosomes.By similarity
Endosome
- early endosome Source: UniProtKB
- early endosome membrane Source: Reactome
- recycling endosome Source: UniProtKB
Plasma Membrane
- clathrin-coated pit Source: UniProtKB-SubCell
Other locations
- axon Source: Ensembl
- clathrin-coated endocytic vesicle Source: UniProtKB
- dendrite Source: Ensembl
- intracellular membrane-bounded organelle Source: HPA
- neuronal cell body Source: Ensembl
Keywords - Cellular componenti
Coated pit, Endosome, MembranePathology & Biotechi
Mutagenesis
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Mutagenesisi | 458 | C → S: Loss of inositol 4-phosphatase activity. Alters TFRC distribution and delays TF recycling. 1 Publication | 1 |
Organism-specific databases
DisGeNETi | 22876 |
OpenTargetsi | ENSG00000198825 |
PharmGKBi | PA134927878 |
Miscellaneous databases
Pharosi | Q9Y2H2, Tbio |
Genetic variation databases
BioMutai | INPP5F |
DMDMi | 187611527 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000331621 | 1 – 1132 | Phosphatidylinositide phosphatase SAC2Add BLAST | 1132 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 827 | PhosphoserineBy similarity | 1 | |
Modified residuei | 830 | PhosphoserineBy similarity | 1 | |
Modified residuei | 878 | PhosphoserineBy similarity | 1 | |
Modified residuei | 881 | PhosphoserineBy similarity | 1 | |
Modified residuei | 907 | PhosphoserineCombined sources | 1 | |
Modified residuei | 910 | PhosphoserineBy similarity | 1 | |
Modified residuei | 1103 | PhosphoserineCombined sources | 1 |
Keywords - PTMi
PhosphoproteinProteomic databases
EPDi | Q9Y2H2 |
jPOSTi | Q9Y2H2 |
MassIVEi | Q9Y2H2 |
MaxQBi | Q9Y2H2 |
PaxDbi | Q9Y2H2 |
PeptideAtlasi | Q9Y2H2 |
PRIDEi | Q9Y2H2 |
ProteomicsDBi | 65795 85781 [Q9Y2H2-1] 85782 [Q9Y2H2-2] 85783 [Q9Y2H2-3] |
PTM databases
DEPODi | INPP5F |
GlyGeni | Q9Y2H2, 2 sites, 1 O-linked glycan (1 site) |
iPTMneti | Q9Y2H2 |
PhosphoSitePlusi | Q9Y2H2 |
SwissPalmi | Q9Y2H2 |
Expressioni
Tissue specificityi
Gene expression databases
Bgeei | ENSG00000198825, Expressed in pons and 239 other tissues |
ExpressionAtlasi | Q9Y2H2, baseline and differential |
Genevisiblei | Q9Y2H2, HS |
Organism-specific databases
HPAi | ENSG00000198825, Tissue enhanced (brain) |
Interactioni
Subunit structurei
GO - Molecular functioni
- protein homodimerization activity Source: UniProtKB
Protein-protein interaction databases
BioGRIDi | 116543, 20 interactors |
ELMi | Q9Y2H2 |
IntActi | Q9Y2H2, 2 interactors |
STRINGi | 9606.ENSP00000354519 |
Miscellaneous databases
RNActi | Q9Y2H2, protein |
Structurei
Secondary structure
3D structure databases
SMRi | Q9Y2H2 |
ModBasei | Search... |
PDBe-KBi | Search... |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 167 – 518 | SACPROSITE-ProRule annotationAdd BLAST | 352 | |
Domaini | 593 – 760 | hSac2PROSITE-ProRule annotationAdd BLAST | 168 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 846 – 875 | DisorderedSequence analysisAdd BLAST | 30 | |
Regioni | 923 – 942 | DisorderedSequence analysisAdd BLAST | 20 | |
Regioni | 974 – 1017 | DisorderedSequence analysisAdd BLAST | 44 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 847 – 875 | Basic and acidic residuesSequence analysisAdd BLAST | 29 |
Phylogenomic databases
eggNOGi | KOG1890, Eukaryota |
GeneTreei | ENSGT00940000155996 |
HOGENOMi | CLU_008079_0_0_1 |
InParanoidi | Q9Y2H2 |
OMAi | DNCCLEL |
OrthoDBi | 359616at2759 |
PhylomeDBi | Q9Y2H2 |
TreeFami | TF313543 |
Family and domain databases
InterProi | View protein in InterPro IPR034753, hSac2 IPR022158, Inositol_phosphatase IPR002013, SAC_dom |
Pfami | View protein in Pfam PF12456, hSac2, 1 hit PF02383, Syja_N, 1 hit |
PROSITEi | View protein in PROSITE PS51791, HSAC2, 1 hit PS50275, SAC, 1 hit |
s (4+)i Sequence
Sequence statusi: Complete.
This entry describes 4 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 4 described isoforms and 16 potential isoforms that are computationally mapped.Show allAlign All
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MELFQAKDHY ILQQGERALW CSRRDGGLQL RPATDLLLAW NPICLGLVEG
60 70 80 90 100
VIGKIQLHSD LPWWLILIRQ KALVGKLPGD HEVCKVTKIA VLSLSEMEPQ
110 120 130 140 150
DLELELCKKH HFGINKPEKI IPSPDDSKFL LKTFTHIKSN VSAPNKKKVK
160 170 180 190 200
ESKEKEKLER RLLEELLKMF MDSESFYYSL TYDLTNSVQR QSTGERDGRP
210 220 230 240 250
LWQKVDDRFF WNKYMIQDLT EIGTPDVDFW IIPMIQGFVQ IEELVVNYTE
260 270 280 290 300
SSDDEKSSPE TPPQESTCVD DIHPRFLVAL ISRRSRHRAG MRYKRRGVDK
310 320 330 340 350
NGNVANYVET EQLIHVHNHT LSFVQTRGSV PVFWSQVGYR YNPRPRLDRS
360 370 380 390 400
EKETVAYFCA HFEEQLNIYK KQVIINLVDQ AGREKIIGDA YLKQVLLFNN
410 420 430 440 450
SHLTYVSFDF HEHCRGMKFE NVQTLTDAIY DIILDMKWCW VDEAGVICKQ
460 470 480 490 500
EGIFRVNCMD CLDRTNVVQA AIARVVMEQQ LKKLGVMPPE QPLPVKCNRI
510 520 530 540 550
YQIMWANNGD SISRQYAGTA ALKGDFTRTG ERKLAGVMKD GVNSANRYYL
560 570 580 590 600
NRFKDAYRQA VIDLMQGIPV TEDLYSIFTK EKEHEALHKE NQRSHQELIS
610 620 630 640 650
QLLQSYMKLL LPDDEKFHGG WALIDCDPSL IDATHRDVDV LLLLSNSAYY
660 670 680 690 700
VAYYDDEVDK VNQYQRLSLE NLEKIEIGPE PTLFGKPKFS CMRLHYRYKE
710 720 730 740 750
ASGYFHTLRA VMRNPEEDGK DTLQCIAEML QITKQAMGSD LPIIEKKLER
760 770 780 790 800
KSSKPHEDII GIRSQNQGSL AQGKNFLMSK FSSLNQKVKQ TKSNVNIGNL
810 820 830 840 850
RKLGNFTKPE MKVNFLKPNL KVNLWKSDSS LETMENTGVM DKVQAESDGD
860 870 880 890 900
MSSDNDSYHS DEFLTNSKSD EDRQLANSLE SVGPIDYVLP SCGIIASAPR
910 920 930 940 950
LGSRSQSLSS TDSSVHAPSE ITVAHGSGLG KGQESPLKKS PSAGDVHILT
960 970 980 990 1000
GFAKPMDIYC HRFVQDAQNK VTHLSETRSV SQQASQERNQ MTNQVSNETQ
1010 1020 1030 1040 1050
SESTEQTPSR PSQLDVSLSA TGPQFLSVEP AHSVASQKTP TSASSMLELE
1060 1070 1080 1090 1100
TGLHVTPSPS ESSSSRAVSP FAKIRSSMVQ VASITQAGLT HGINFAVSKV
1110 1120 1130
QKSPPEPEII NQVQQNELKK MFIQCQTRII QI
Computationally mapped potential isoform sequencesi
There are 16 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketA0A3B3ITL0 | A0A3B3ITL0_HUMAN | Phosphatidylinositide phosphatase S... | INPP5F | 1,036 | Annotation score: | ||
A0A3B3IRJ9 | A0A3B3IRJ9_HUMAN | Phosphatidylinositide phosphatase S... | INPP5F | 1,070 | Annotation score: | ||
A0A0J9YY79 | A0A0J9YY79_HUMAN | Phosphatidylinositide phosphatase S... | INPP5F | 183 | Annotation score: | ||
A0A0J9YYL5 | A0A0J9YYL5_HUMAN | Phosphatidylinositide phosphatase S... | INPP5F | 82 | Annotation score: | ||
A0A3B3ITR9 | A0A3B3ITR9_HUMAN | Phosphatidylinositide phosphatase S... | INPP5F | 646 | Annotation score: | ||
A0A3B3ISI3 | A0A3B3ISI3_HUMAN | Phosphatidylinositide phosphatase S... | INPP5F | 747 | Annotation score: | ||
A0A3B3ISJ5 | A0A3B3ISJ5_HUMAN | Phosphatidylinositide phosphatase S... | INPP5F | 460 | Annotation score: | ||
A0A3B3ISK0 | A0A3B3ISK0_HUMAN | Phosphatidylinositide phosphatase S... | INPP5F | 120 | Annotation score: | ||
A0A0J9YVW6 | A0A0J9YVW6_HUMAN | Phosphatidylinositide phosphatase S... | INPP5F | 57 | Annotation score: | ||
A0A0J9YWP2 | A0A0J9YWP2_HUMAN | Phosphatidylinositide phosphatase S... | INPP5F | 105 | Annotation score: | ||
There are more potential isoformsShow all |
Sequence cautioni
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 386 | I → V in AAI11494 (PubMed:15489334).Curated | 1 | |
Sequence conflicti | 654 | Y → N in BAG52363 (PubMed:14702039).Curated | 1 | |
Sequence conflicti | 1008 | P → L in BAG52363 (PubMed:14702039).Curated | 1 | |
Sequence conflicti | 1019 | S → P in BAG52363 (PubMed:14702039).Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_042907 | 453 | I → V. Corresponds to variant dbSNP:rs3736822Ensembl. | 1 | |
Natural variantiVAR_042908 | 997 | N → D2 PublicationsCorresponds to variant dbSNP:rs3188055Ensembl. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_046366 | 1 – 19 | MELFQ…GERAL → MCHDVIFMAWLKQQFSECT in isoform 4. 1 PublicationAdd BLAST | 19 | |
Alternative sequenceiVSP_046367 | 20 – 629 | Missing in isoform 4. 1 PublicationAdd BLAST | 610 | |
Alternative sequenceiVSP_033266 | 206 – 219 | DDRFF…MIQDL → PLTARRAGFALGKK in isoform 3. 1 PublicationAdd BLAST | 14 | |
Alternative sequenceiVSP_033267 | 220 – 1132 | Missing in isoform 3. 1 PublicationAdd BLAST | 913 | |
Alternative sequenceiVSP_033268 | 373 – 375 | VII → QQK in isoform 2. 1 Publication | 3 | |
Alternative sequenceiVSP_033269 | 376 – 1132 | Missing in isoform 2. 1 PublicationAdd BLAST | 757 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AB023183 mRNA Translation: BAA76810.2 Different initiation. AK091448 mRNA Translation: BAG52363.1 AC027672 Genomic DNA No translation available. AL133461 Genomic DNA No translation available. AL158014 Genomic DNA No translation available. CH471066 Genomic DNA Translation: EAW49379.1 CH471066 Genomic DNA Translation: EAW49380.1 CH471066 Genomic DNA Translation: EAW49381.1 BC052367 mRNA Translation: AAH52367.1 BC067820 mRNA Translation: AAH67820.1 BC082755 mRNA Translation: AAH82755.1 BC111493 mRNA Translation: AAI11494.1 AL137528 mRNA Translation: CAB70792.1 AF113227 mRNA Translation: AAG39298.1 AF109361 mRNA Translation: AAQ13509.1 |
CCDSi | CCDS58098.1 [Q9Y2H2-4] CCDS7616.1 [Q9Y2H2-1] CCDS81513.1 [Q9Y2H2-3] |
PIRi | T46372 |
RefSeqi | NP_001230123.1, NM_001243194.1 [Q9Y2H2-4] NP_001230124.1, NM_001243195.1 [Q9Y2H2-3] NP_055752.1, NM_014937.3 [Q9Y2H2-1] |
Genome annotation databases
Ensembli | ENST00000369081; ENSP00000489864; ENSG00000198825 [Q9Y2H2-3] ENST00000650409; ENSP00000496955; ENSG00000198825 [Q9Y2H2-4] ENST00000650623; ENSP00000497527; ENSG00000198825 |
GeneIDi | 22876 |
KEGGi | hsa:22876 |
MANE-Selecti | ENST00000650623.2; ENSP00000497527.1; NM_014937.4; NP_055752.1 |
UCSCi | uc001leo.4, human [Q9Y2H2-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AB023183 mRNA Translation: BAA76810.2 Different initiation. AK091448 mRNA Translation: BAG52363.1 AC027672 Genomic DNA No translation available. AL133461 Genomic DNA No translation available. AL158014 Genomic DNA No translation available. CH471066 Genomic DNA Translation: EAW49379.1 CH471066 Genomic DNA Translation: EAW49380.1 CH471066 Genomic DNA Translation: EAW49381.1 BC052367 mRNA Translation: AAH52367.1 BC067820 mRNA Translation: AAH67820.1 BC082755 mRNA Translation: AAH82755.1 BC111493 mRNA Translation: AAI11494.1 AL137528 mRNA Translation: CAB70792.1 AF113227 mRNA Translation: AAG39298.1 AF109361 mRNA Translation: AAQ13509.1 |
CCDSi | CCDS58098.1 [Q9Y2H2-4] CCDS7616.1 [Q9Y2H2-1] CCDS81513.1 [Q9Y2H2-3] |
PIRi | T46372 |
RefSeqi | NP_001230123.1, NM_001243194.1 [Q9Y2H2-4] NP_001230124.1, NM_001243195.1 [Q9Y2H2-3] NP_055752.1, NM_014937.3 [Q9Y2H2-1] |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
4XUU | X-ray | 2.62 | A/B/C/D | 593-760 | [»] | |
SMRi | Q9Y2H2 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 116543, 20 interactors |
ELMi | Q9Y2H2 |
IntActi | Q9Y2H2, 2 interactors |
STRINGi | 9606.ENSP00000354519 |
PTM databases
DEPODi | INPP5F |
GlyGeni | Q9Y2H2, 2 sites, 1 O-linked glycan (1 site) |
iPTMneti | Q9Y2H2 |
PhosphoSitePlusi | Q9Y2H2 |
SwissPalmi | Q9Y2H2 |
Genetic variation databases
BioMutai | INPP5F |
DMDMi | 187611527 |
Proteomic databases
EPDi | Q9Y2H2 |
jPOSTi | Q9Y2H2 |
MassIVEi | Q9Y2H2 |
MaxQBi | Q9Y2H2 |
PaxDbi | Q9Y2H2 |
PeptideAtlasi | Q9Y2H2 |
PRIDEi | Q9Y2H2 |
ProteomicsDBi | 65795 85781 [Q9Y2H2-1] 85782 [Q9Y2H2-2] 85783 [Q9Y2H2-3] |
Protocols and materials databases
Antibodypediai | 32161, 97 antibodies from 18 providers |
DNASUi | 22876 |
Genome annotation databases
Ensembli | ENST00000369081; ENSP00000489864; ENSG00000198825 [Q9Y2H2-3] ENST00000650409; ENSP00000496955; ENSG00000198825 [Q9Y2H2-4] ENST00000650623; ENSP00000497527; ENSG00000198825 |
GeneIDi | 22876 |
KEGGi | hsa:22876 |
MANE-Selecti | ENST00000650623.2; ENSP00000497527.1; NM_014937.4; NP_055752.1 |
UCSCi | uc001leo.4, human [Q9Y2H2-1] |
Organism-specific databases
CTDi | 22876 |
DisGeNETi | 22876 |
GeneCardsi | INPP5F |
HGNCi | HGNC:17054, INPP5F |
HPAi | ENSG00000198825, Tissue enhanced (brain) |
MIMi | 609389, gene |
neXtProti | NX_Q9Y2H2 |
OpenTargetsi | ENSG00000198825 |
PharmGKBi | PA134927878 |
VEuPathDBi | HostDB:ENSG00000198825 |
HUGEi | Search... |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG1890, Eukaryota |
GeneTreei | ENSGT00940000155996 |
HOGENOMi | CLU_008079_0_0_1 |
InParanoidi | Q9Y2H2 |
OMAi | DNCCLEL |
OrthoDBi | 359616at2759 |
PhylomeDBi | Q9Y2H2 |
TreeFami | TF313543 |
Enzyme and pathway databases
PathwayCommonsi | Q9Y2H2 |
Reactomei | R-HSA-1660516, Synthesis of PIPs at the early endosome membrane |
SABIO-RKi | Q9Y2H2 |
SignaLinki | Q9Y2H2 |
Miscellaneous databases
BioGRID-ORCSi | 22876, 12 hits in 1040 CRISPR screens |
ChiTaRSi | INPP5F, human |
GenomeRNAii | 22876 |
Pharosi | Q9Y2H2, Tbio |
PROi | PR:Q9Y2H2 |
RNActi | Q9Y2H2, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000198825, Expressed in pons and 239 other tissues |
ExpressionAtlasi | Q9Y2H2, baseline and differential |
Genevisiblei | Q9Y2H2, HS |
Family and domain databases
InterProi | View protein in InterPro IPR034753, hSac2 IPR022158, Inositol_phosphatase IPR002013, SAC_dom |
Pfami | View protein in Pfam PF12456, hSac2, 1 hit PF02383, Syja_N, 1 hit |
PROSITEi | View protein in PROSITE PS51791, HSAC2, 1 hit PS50275, SAC, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | SAC2_HUMAN | |
Accessioni | Q9Y2H2Primary (citable) accession number: Q9Y2H2 Secondary accession number(s): B3KRF1 Q9NT51 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | April 29, 2008 |
Last sequence update: | April 29, 2008 | |
Last modified: | February 23, 2022 | |
This is version 146 of the entry and version 3 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- Human chromosome 10
Human chromosome 10: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references