UniProtKB - Q9Y2H1 (ST38L_HUMAN)
Serine/threonine-protein kinase 38-like
STK38L
Functioni
Catalytic activityi
Cofactori
Activity regulationi
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Binding sitei | 119 | ATPPROSITE-ProRule annotation1 Publication | 1 | |
Active sitei | 213 | Proton acceptorPROSITE-ProRule annotation | 1 |
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Nucleotide bindingi | 96 – 104 | ATPPROSITE-ProRule annotationBy similarity | 9 |
GO - Molecular functioni
- actin binding Source: UniProtKB-KW
- ATP binding Source: UniProtKB
- magnesium ion binding Source: UniProtKB
- protein serine/threonine kinase activity Source: UniProtKB
GO - Biological processi
- intracellular signal transduction Source: UniProtKB
- peptidyl-serine phosphorylation Source: GO_Central
- protein phosphorylation Source: UniProtKB
- regulation of cellular component organization Source: UniProtKB
Keywordsi
Molecular function | Actin-binding, Kinase, Serine/threonine-protein kinase, Transferase |
Ligand | ATP-binding, Magnesium, Metal-binding, Nucleotide-binding |
Enzyme and pathway databases
PathwayCommonsi | Q9Y2H1 |
SignaLinki | Q9Y2H1 |
SIGNORi | Q9Y2H1 |
Names & Taxonomyi
Protein namesi | Recommended name: Serine/threonine-protein kinase 38-like (EC:2.7.11.1)Alternative name(s): NDR2 protein kinase Nuclear Dbf2-related kinase 2 |
Gene namesi | |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
EuPathDBi | HostDB:ENSG00000211455.7 |
HGNCi | HGNC:17848, STK38L |
MIMi | 615836, gene |
neXtProti | NX_Q9Y2H1 |
Subcellular locationi
Cytoskeleton
Other locations
Note: Associated with the actin cytoskeleton. Co-localizes with STK24/MST3 in the membrane.
Cytoskeleton
- actin cytoskeleton Source: UniProtKB
Cytosol
- cytosol Source: HPA
Other locations
Keywords - Cellular componenti
Cytoplasm, Cytoskeleton, MembranePathology & Biotechi
Mutagenesis
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Mutagenesisi | 75 | T → A: Decreased kinase activity. Reduced binding of S100B. 1 Publication | 1 | |
Mutagenesisi | 119 | K → A: Loss of autophosphorylation and kinase activity. 1 Publication | 1 | |
Mutagenesisi | 282 | S → A: Loss of autophosphorylation and kinase activity. 1 Publication | 1 | |
Mutagenesisi | 442 | T → A: Decreased kinase activity. 1 Publication | 1 |
Organism-specific databases
DisGeNETi | 23012 |
OpenTargetsi | ENSG00000211455 |
PharmGKBi | PA38252 |
Miscellaneous databases
Pharosi | Q9Y2H1, Tchem |
Chemistry databases
ChEMBLi | CHEMBL4851 |
DrugBanki | DB12010, Fostamatinib |
DrugCentrali | Q9Y2H1 |
Polymorphism and mutation databases
BioMutai | STK38L |
DMDMi | 56749668 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Initiator methioninei | Removed1 Publication | |||
ChainiPRO_0000086720 | 2 – 464 | Serine/threonine-protein kinase 38-likeAdd BLAST | 463 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 2 | N-acetylalanine1 Publication | 1 | |
Modified residuei | 75 | Phosphothreonine1 Publication | 1 | |
Modified residuei | 282 | Phosphoserine; by autocatalysis1 Publication | 1 | |
Modified residuei | 442 | Phosphothreonine; by STK24/MST32 Publications | 1 |
Keywords - PTMi
Acetylation, PhosphoproteinProteomic databases
EPDi | Q9Y2H1 |
jPOSTi | Q9Y2H1 |
MassIVEi | Q9Y2H1 |
PaxDbi | Q9Y2H1 |
PeptideAtlasi | Q9Y2H1 |
PRIDEi | Q9Y2H1 |
ProteomicsDBi | 5904 85780 [Q9Y2H1-1] |
PTM databases
iPTMneti | Q9Y2H1 |
PhosphoSitePlusi | Q9Y2H1 |
Expressioni
Tissue specificityi
Gene expression databases
Bgeei | ENSG00000211455, Expressed in thoracic aorta and 239 other tissues |
ExpressionAtlasi | Q9Y2H1, baseline and differential |
Genevisiblei | Q9Y2H1, HS |
Organism-specific databases
HPAi | ENSG00000211455, Low tissue specificity |
Interactioni
Subunit structurei
Homodimeric S100B binds two molecules of STK38L.
Interacts with MICAL1; leading to inhibit the protein kinase activity by antagonizing activation by MST1/STK4 (By similarity).
Interacts with MOB1 and MOB2.
By similarity2 PublicationsBinary interactionsi
Hide detailsQ9Y2H1
With | #Exp. | IntAct |
---|---|---|
CDC37 [Q16543] | 6 | EBI-991501,EBI-295634 |
MOB1A [Q9H8S9] | 5 | EBI-991501,EBI-748229 |
MOB2 [Q70IA6] | 10 | EBI-991501,EBI-2558739 |
GO - Molecular functioni
- actin binding Source: UniProtKB-KW
Protein-protein interaction databases
BioGRIDi | 116654, 34 interactors |
IntActi | Q9Y2H1, 100 interactors |
MINTi | Q9Y2H1 |
STRINGi | 9606.ENSP00000373684 |
Chemistry databases
BindingDBi | Q9Y2H1 |
Miscellaneous databases
RNActi | Q9Y2H1, protein |
Structurei
Secondary structure
3D structure databases
SMRi | Q9Y2H1 |
ModBasei | Search... |
PDBe-KBi | Search... |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 90 – 383 | Protein kinasePROSITE-ProRule annotationAdd BLAST | 294 | |
Domaini | 384 – 453 | AGC-kinase C-terminalPROSITE-ProRule annotationAdd BLAST | 70 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 63 – 88 | S100B bindingBy similarityAdd BLAST | 26 |
Sequence similaritiesi
Phylogenomic databases
eggNOGi | KOG0605, Eukaryota |
GeneTreei | ENSGT00940000153544 |
HOGENOMi | CLU_000288_67_2_1 |
InParanoidi | Q9Y2H1 |
OMAi | LRFCVDS |
OrthoDBi | 759391at2759 |
PhylomeDBi | Q9Y2H1 |
TreeFami | TF105337 |
Family and domain databases
InterProi | View protein in InterPro IPR000961, AGC-kinase_C IPR011009, Kinase-like_dom_sf IPR017892, Pkinase_C IPR000719, Prot_kinase_dom IPR017441, Protein_kinase_ATP_BS IPR008271, Ser/Thr_kinase_AS |
Pfami | View protein in Pfam PF00069, Pkinase, 1 hit PF00433, Pkinase_C, 1 hit |
SMARTi | View protein in SMART SM00133, S_TK_X, 1 hit SM00220, S_TKc, 1 hit |
SUPFAMi | SSF56112, SSF56112, 1 hit |
PROSITEi | View protein in PROSITE PS51285, AGC_KINASE_CTER, 1 hit PS00107, PROTEIN_KINASE_ATP, 1 hit PS50011, PROTEIN_KINASE_DOM, 1 hit PS00108, PROTEIN_KINASE_ST, 1 hit |
s (2+)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 2 described isoforms and 7 potential isoforms that are computationally mapped.Show allAlign All
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MAMTAGTTTT FPMSNHTRER VTVAKLTLEN FYSNLILQHE ERETRQKKLE
60 70 80 90 100
VAMEEEGLAD EEKKLRRSQH ARKETEFLRL KRTRLGLDDF ESLKVIGRGA
110 120 130 140 150
FGEVRLVQKK DTGHIYAMKI LRKSDMLEKE QVAHIRAERD ILVEADGAWV
160 170 180 190 200
VKMFYSFQDK RNLYLIMEFL PGGDMMTLLM KKDTLTEEET QFYISETVLA
210 220 230 240 250
IDAIHQLGFI HRDIKPDNLL LDAKGHVKLS DFGLCTGLKK AHRTEFYRNL
260 270 280 290 300
THNPPSDFSF QNMNSKRKAE TWKKNRRQLA YSTVGTPDYI APEVFMQTGY
310 320 330 340 350
NKLCDWWSLG VIMYEMLIGY PPFCSETPQE TYRKVMNWKE TLVFPPEVPI
360 370 380 390 400
SEKAKDLILR FCIDSENRIG NSGVEEIKGH PFFEGVDWEH IRERPAAIPI
410 420 430 440 450
EIKSIDDTSN FDDFPESDIL QPVPNTTEPD YKSKDWVFLN YTYKRFEGLT
460
QRGSIPTYMK AGKL
Computationally mapped potential isoform sequencesi
There are 7 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketF5GY51 | F5GY51_HUMAN | Serine/threonine-protein kinase 38-... | STK38L | 131 | Annotation score: | ||
F5H7Z3 | F5H7Z3_HUMAN | Serine/threonine-protein kinase 38-... | STK38L | 94 | Annotation score: | ||
F5H277 | F5H277_HUMAN | Serine/threonine-protein kinase 38-... | STK38L | 213 | Annotation score: | ||
H0YGN4 | H0YGN4_HUMAN | Serine/threonine-protein kinase 38-... | STK38L | 87 | Annotation score: | ||
I3L0D0 | I3L0D0_HUMAN | Serine/threonine-protein kinase 38-... | STK38L | 89 | Annotation score: | ||
F5H5E6 | F5H5E6_HUMAN | Serine/threonine-protein kinase 38-... | STK38L | 56 | Annotation score: | ||
F5H0V1 | F5H0V1_HUMAN | Serine/threonine-protein kinase 38-... | STK38L | 64 | Annotation score: |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_041199 | 99 | G → A in a aLL TEL/AML1+ sample; somatic mutation. 1 Publication | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_056233 | 1 – 52 | Missing in isoform 2. 1 PublicationAdd BLAST | 52 | |
Alternative sequenceiVSP_056234 | 62 – 102 | Missing in isoform 2. 1 PublicationAdd BLAST | 41 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AB023182 mRNA Translation: BAA76809.2 AK291055 mRNA Translation: BAF83744.1 AK304755 mRNA Translation: BAG65510.1 AC092827 Genomic DNA No translation available. AC092829 Genomic DNA No translation available. CH471094 Genomic DNA Translation: EAW96549.1 BC028603 mRNA Translation: AAH28603.1 |
CCDSi | CCDS31761.1 [Q9Y2H1-1] |
RefSeqi | NP_055815.1, NM_015000.3 [Q9Y2H1-1] XP_006719121.1, XM_006719058.3 [Q9Y2H1-1] XP_011518915.1, XM_011520613.2 [Q9Y2H1-2] XP_016874525.1, XM_017019036.1 |
Genome annotation databases
Ensembli | ENST00000389032; ENSP00000373684; ENSG00000211455 [Q9Y2H1-1] |
GeneIDi | 23012 |
KEGGi | hsa:23012 |
UCSCi | uc001rhr.4, human [Q9Y2H1-1] |
Keywords - Coding sequence diversityi
Alternative splicing, PolymorphismSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AB023182 mRNA Translation: BAA76809.2 AK291055 mRNA Translation: BAF83744.1 AK304755 mRNA Translation: BAG65510.1 AC092827 Genomic DNA No translation available. AC092829 Genomic DNA No translation available. CH471094 Genomic DNA Translation: EAW96549.1 BC028603 mRNA Translation: AAH28603.1 |
CCDSi | CCDS31761.1 [Q9Y2H1-1] |
RefSeqi | NP_055815.1, NM_015000.3 [Q9Y2H1-1] XP_006719121.1, XM_006719058.3 [Q9Y2H1-1] XP_011518915.1, XM_011520613.2 [Q9Y2H1-2] XP_016874525.1, XM_017019036.1 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
5XQZ | X-ray | 2.10 | C/D | 25-87 | [»] | |
SMRi | Q9Y2H1 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 116654, 34 interactors |
IntActi | Q9Y2H1, 100 interactors |
MINTi | Q9Y2H1 |
STRINGi | 9606.ENSP00000373684 |
Chemistry databases
BindingDBi | Q9Y2H1 |
ChEMBLi | CHEMBL4851 |
DrugBanki | DB12010, Fostamatinib |
DrugCentrali | Q9Y2H1 |
PTM databases
iPTMneti | Q9Y2H1 |
PhosphoSitePlusi | Q9Y2H1 |
Polymorphism and mutation databases
BioMutai | STK38L |
DMDMi | 56749668 |
Proteomic databases
EPDi | Q9Y2H1 |
jPOSTi | Q9Y2H1 |
MassIVEi | Q9Y2H1 |
PaxDbi | Q9Y2H1 |
PeptideAtlasi | Q9Y2H1 |
PRIDEi | Q9Y2H1 |
ProteomicsDBi | 5904 85780 [Q9Y2H1-1] |
Protocols and materials databases
Antibodypediai | 24379, 239 antibodies |
DNASUi | 23012 |
Genome annotation databases
Ensembli | ENST00000389032; ENSP00000373684; ENSG00000211455 [Q9Y2H1-1] |
GeneIDi | 23012 |
KEGGi | hsa:23012 |
UCSCi | uc001rhr.4, human [Q9Y2H1-1] |
Organism-specific databases
CTDi | 23012 |
DisGeNETi | 23012 |
EuPathDBi | HostDB:ENSG00000211455.7 |
GeneCardsi | STK38L |
HGNCi | HGNC:17848, STK38L |
HPAi | ENSG00000211455, Low tissue specificity |
MIMi | 615836, gene |
neXtProti | NX_Q9Y2H1 |
OpenTargetsi | ENSG00000211455 |
PharmGKBi | PA38252 |
HUGEi | Search... |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG0605, Eukaryota |
GeneTreei | ENSGT00940000153544 |
HOGENOMi | CLU_000288_67_2_1 |
InParanoidi | Q9Y2H1 |
OMAi | LRFCVDS |
OrthoDBi | 759391at2759 |
PhylomeDBi | Q9Y2H1 |
TreeFami | TF105337 |
Enzyme and pathway databases
PathwayCommonsi | Q9Y2H1 |
SignaLinki | Q9Y2H1 |
SIGNORi | Q9Y2H1 |
Miscellaneous databases
BioGRID-ORCSi | 23012, 2 hits in 874 CRISPR screens |
ChiTaRSi | STK38L, human |
GeneWikii | STK38L |
GenomeRNAii | 23012 |
Pharosi | Q9Y2H1, Tchem |
PROi | PR:Q9Y2H1 |
RNActi | Q9Y2H1, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000211455, Expressed in thoracic aorta and 239 other tissues |
ExpressionAtlasi | Q9Y2H1, baseline and differential |
Genevisiblei | Q9Y2H1, HS |
Family and domain databases
InterProi | View protein in InterPro IPR000961, AGC-kinase_C IPR011009, Kinase-like_dom_sf IPR017892, Pkinase_C IPR000719, Prot_kinase_dom IPR017441, Protein_kinase_ATP_BS IPR008271, Ser/Thr_kinase_AS |
Pfami | View protein in Pfam PF00069, Pkinase, 1 hit PF00433, Pkinase_C, 1 hit |
SMARTi | View protein in SMART SM00133, S_TK_X, 1 hit SM00220, S_TKc, 1 hit |
SUPFAMi | SSF56112, SSF56112, 1 hit |
PROSITEi | View protein in PROSITE PS51285, AGC_KINASE_CTER, 1 hit PS00107, PROTEIN_KINASE_ATP, 1 hit PS50011, PROTEIN_KINASE_DOM, 1 hit PS00108, PROTEIN_KINASE_ST, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | ST38L_HUMAN | |
Accessioni | Q9Y2H1Primary (citable) accession number: Q9Y2H1 Secondary accession number(s): A8K4U0, B4E3J8, Q8TBX7 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | December 21, 2004 |
Last sequence update: | December 21, 2004 | |
Last modified: | December 2, 2020 | |
This is version 181 of the entry and version 3 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Direct protein sequencing, Reference proteomeDocuments
- Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families - Human chromosome 12
Human chromosome 12: entries, gene names and cross-references to MIM - Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations - Human and mouse protein kinases
Human and mouse protein kinases: classification and index