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Protein

Serine/threonine-protein kinase 38-like

Gene

STK38L

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Involved in the regulation of structural processes in differentiating and mature neuronal cells.By similarity2 Publications

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.

Cofactori

Enzyme regulationi

Activated by binding of S100B which releases autoinhibitory N-lobe interactions, enabling ATP to bind and the autophosphorylation of Ser-282. Thr-442 then undergoes calcium-dependent phosphorylation by STK24/MST3. Interactions between phosphorylated Thr-442 and the N-lobe promote additional structural changes that complete the activation of the kinase. Autoinhibition is also released by the binding of MOB1/MOBKL1A and MOB2/HCCA2 to the N-terminal of STK38L.3 Publications

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei119ATPPROSITE-ProRule annotation1 Publication1
Active sitei213Proton acceptorPROSITE-ProRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi96 – 104ATPPROSITE-ProRule annotationBy similarity9

GO - Molecular functioni

  • actin binding Source: UniProtKB-KW
  • ATP binding Source: UniProtKB
  • magnesium ion binding Source: UniProtKB
  • protein serine/threonine kinase activity Source: UniProtKB

GO - Biological processi

  • intracellular signal transduction Source: UniProtKB
  • peptidyl-serine phosphorylation Source: GO_Central
  • protein phosphorylation Source: UniProtKB
  • regulation of cellular component organization Source: UniProtKB

Keywordsi

Molecular functionActin-binding, Kinase, Serine/threonine-protein kinase, Transferase
LigandATP-binding, Magnesium, Metal-binding, Nucleotide-binding

Enzyme and pathway databases

SignaLinkiQ9Y2H1
SIGNORiQ9Y2H1

Names & Taxonomyi

Protein namesi
Recommended name:
Serine/threonine-protein kinase 38-like (EC:2.7.11.1)
Alternative name(s):
NDR2 protein kinase
Nuclear Dbf2-related kinase 2
Gene namesi
Name:STK38LImported
Synonyms:KIAA0965Imported, NDR21 Publication
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 12

Organism-specific databases

EuPathDBiHostDB:ENSG00000211455.7
HGNCiHGNC:17848 STK38L
MIMi615836 gene
neXtProtiNX_Q9Y2H1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton, Membrane

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi75T → A: Decreased kinase activity. Reduced binding of S100B. 1 Publication1
Mutagenesisi119K → A: Loss of autophosphorylation and kinase activity. 1 Publication1
Mutagenesisi282S → A: Loss of autophosphorylation and kinase activity. 1 Publication1
Mutagenesisi442T → A: Decreased kinase activity. 1 Publication1

Organism-specific databases

DisGeNETi23012
OpenTargetsiENSG00000211455
PharmGKBiPA38252

Chemistry databases

ChEMBLiCHEMBL4851
GuidetoPHARMACOLOGYi1518

Polymorphism and mutation databases

BioMutaiSTK38L
DMDMi56749668

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemoved1 Publication
ChainiPRO_00000867202 – 464Serine/threonine-protein kinase 38-likeAdd BLAST463

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanine1 Publication1
Modified residuei75Phosphothreonine1 Publication1
Modified residuei282Phosphoserine; by autocatalysis1 Publication1
Modified residuei442Phosphothreonine; by STK24/MST32 Publications1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiQ9Y2H1
PaxDbiQ9Y2H1
PeptideAtlasiQ9Y2H1
PRIDEiQ9Y2H1
ProteomicsDBi85780

PTM databases

iPTMnetiQ9Y2H1
PhosphoSitePlusiQ9Y2H1

Expressioni

Tissue specificityi

Ubiquitously expressed with highest levels observed in the thymus.1 Publication

Gene expression databases

BgeeiENSG00000211455
CleanExiHS_STK38L
ExpressionAtlasiQ9Y2H1 baseline and differential
GenevisibleiQ9Y2H1 HS

Organism-specific databases

HPAiHPA038623
HPA051324

Interactioni

Subunit structurei

Homodimeric S100B binds two molecules of STK38L. Interacts with MICAL1; leading to inhibit the protein kinase activity by antagonizing activation by MST1/STK4 (By similarity). Interacts with MOB1 and MOB2.By similarity2 Publications

Binary interactionsi

Show more details

GO - Molecular functioni

Protein-protein interaction databases

BioGridi116654, 27 interactors
IntActiQ9Y2H1, 9 interactors
MINTiQ9Y2H1
STRINGi9606.ENSP00000373684

Chemistry databases

BindingDBiQ9Y2H1

Structurei

3D structure databases

ProteinModelPortaliQ9Y2H1
SMRiQ9Y2H1
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini90 – 383Protein kinasePROSITE-ProRule annotationAdd BLAST294
Domaini384 – 453AGC-kinase C-terminalAdd BLAST70

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni63 – 88S100B bindingBy similarityAdd BLAST26

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG0605 Eukaryota
ENOG410XQC0 LUCA
GeneTreeiENSGT00760000118994
HOGENOMiHOG000233033
HOVERGENiHBG104247
InParanoidiQ9Y2H1
KOiK08790
OMAiNAIHLTM
OrthoDBiEOG091G028J
PhylomeDBiQ9Y2H1
TreeFamiTF105337

Family and domain databases

InterProiView protein in InterPro
IPR000961 AGC-kinase_C
IPR011009 Kinase-like_dom_sf
IPR017892 Pkinase_C
IPR000719 Prot_kinase_dom
IPR017441 Protein_kinase_ATP_BS
IPR008271 Ser/Thr_kinase_AS
PfamiView protein in Pfam
PF00069 Pkinase, 1 hit
PF00433 Pkinase_C, 1 hit
SMARTiView protein in SMART
SM00133 S_TK_X, 1 hit
SM00220 S_TKc, 1 hit
SUPFAMiSSF56112 SSF56112, 2 hits
PROSITEiView protein in PROSITE
PS51285 AGC_KINASE_CTER, 1 hit
PS00107 PROTEIN_KINASE_ATP, 1 hit
PS50011 PROTEIN_KINASE_DOM, 1 hit
PS00108 PROTEIN_KINASE_ST, 1 hit

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9Y2H1-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAMTAGTTTT FPMSNHTRER VTVAKLTLEN FYSNLILQHE ERETRQKKLE
60 70 80 90 100
VAMEEEGLAD EEKKLRRSQH ARKETEFLRL KRTRLGLDDF ESLKVIGRGA
110 120 130 140 150
FGEVRLVQKK DTGHIYAMKI LRKSDMLEKE QVAHIRAERD ILVEADGAWV
160 170 180 190 200
VKMFYSFQDK RNLYLIMEFL PGGDMMTLLM KKDTLTEEET QFYISETVLA
210 220 230 240 250
IDAIHQLGFI HRDIKPDNLL LDAKGHVKLS DFGLCTGLKK AHRTEFYRNL
260 270 280 290 300
THNPPSDFSF QNMNSKRKAE TWKKNRRQLA YSTVGTPDYI APEVFMQTGY
310 320 330 340 350
NKLCDWWSLG VIMYEMLIGY PPFCSETPQE TYRKVMNWKE TLVFPPEVPI
360 370 380 390 400
SEKAKDLILR FCIDSENRIG NSGVEEIKGH PFFEGVDWEH IRERPAAIPI
410 420 430 440 450
EIKSIDDTSN FDDFPESDIL QPVPNTTEPD YKSKDWVFLN YTYKRFEGLT
460
QRGSIPTYMK AGKL
Length:464
Mass (Da):54,003
Last modified:December 21, 2004 - v3
Checksum:i71347E80BC3ADCB3
GO
Isoform 2 (identifier: Q9Y2H1-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-52: Missing.
     62-102: Missing.

Note: No experimental confirmation available.
Show »
Length:371
Mass (Da):43,170
Checksum:iA8E29D3ED6CE7959
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_04119999G → A in a aLL TEL/AML1+ sample; somatic mutation. 1 Publication1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0562331 – 52Missing in isoform 2. 1 PublicationAdd BLAST52
Alternative sequenceiVSP_05623462 – 102Missing in isoform 2. 1 PublicationAdd BLAST41

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB023182 mRNA Translation: BAA76809.2
AK291055 mRNA Translation: BAF83744.1
AK304755 mRNA Translation: BAG65510.1
AC092827 Genomic DNA No translation available.
AC092829 Genomic DNA No translation available.
CH471094 Genomic DNA Translation: EAW96549.1
BC028603 mRNA Translation: AAH28603.1
CCDSiCCDS31761.1 [Q9Y2H1-1]
RefSeqiNP_055815.1, NM_015000.3 [Q9Y2H1-1]
XP_006719121.1, XM_006719058.3 [Q9Y2H1-1]
XP_011518915.1, XM_011520613.2 [Q9Y2H1-2]
XP_016874525.1, XM_017019036.1 [Q9Y2H1-1]
UniGeneiHs.184523

Genome annotation databases

EnsembliENST00000389032; ENSP00000373684; ENSG00000211455 [Q9Y2H1-1]
GeneIDi23012
KEGGihsa:23012
UCSCiuc001rhr.4 human [Q9Y2H1-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Entry informationi

Entry nameiST38L_HUMAN
AccessioniPrimary (citable) accession number: Q9Y2H1
Secondary accession number(s): A8K4U0, B4E3J8, Q8TBX7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 21, 2004
Last sequence update: December 21, 2004
Last modified: July 18, 2018
This is version 164 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Human and mouse protein kinases
    Human and mouse protein kinases: classification and index
  6. SIMILARITY comments
    Index of protein domains and families

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