STK38L

Functionⁱ

Involved in the regulation of structural processes in differentiating and mature neuronal cells.By similarity2 Publications

Catalytic activityⁱ

ATP + a protein = ADP + a phosphoprotein.

Cofactorⁱ

Mg²⁺

Activity regulationⁱ

Activated by binding of S100B which releases autoinhibitory N-lobe interactions, enabling ATP to bind and the autophosphorylation of Ser-282. Thr-442 then undergoes calcium-dependent phosphorylation by STK24/MST3. Interactions between phosphorylated Thr-442 and the N-lobe promote additional structural changes that complete the activation of the kinase. Autoinhibition is also released by the binding of MOB1/MOBKL1A and MOB2/HCCA2 to the N-terminal of STK38L.3 Publications

Sites

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Binding siteⁱ	119	ATPPROSITE-ProRule annotation1 Publication		1
Active siteⁱ	213	Proton acceptorPROSITE-ProRule annotation		1

Regions

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Nucleotide bindingⁱ	96 – 104	ATPPROSITE-ProRule annotationBy similarity		9

GO - Molecular functionⁱ

actin binding Source: UniProtKB-KW
ATP binding
Source: UniProtKB
Inferred from direct assayⁱ
- 15067004
magnesium ion binding
Source: UniProtKB
Inferred from direct assayⁱ
- 15067004
protein serine/threonine kinase activity
Source: UniProtKB
Inferred from direct assayⁱ
- 15067004

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

intracellular signal transduction
Source: UniProtKB
Inferred from direct assayⁱ
- 15067004
peptidyl-serine phosphorylation Source: GO_Central
protein phosphorylation
Source: UniProtKB
Inferred from direct assayⁱ
- 15067004
regulation of cellular component organization Source: UniProtKB

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Actin-binding, Kinase, Serine/threonine-protein kinase, Transferase
Ligand	ATP-binding, Magnesium, Metal-binding, Nucleotide-binding

Enzyme and pathway databases

SignaLinkⁱ	Q9Y2H1
SIGNORⁱ	Q9Y2H1

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Serine/threonine-protein kinase 38-like (EC:2.7.11.1) Alternative name(s): NDR2 protein kinase Nuclear Dbf2-related kinase 2
Gene namesⁱ	Name:STK38LImported Synonyms:KIAA0965Imported, NDR21 Publication
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 12

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000211455.7
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:17848 STK38L
MIMⁱ	615836 gene
neXtProtⁱ	NX_Q9Y2H1

Keywords - Cellular componentⁱ

Cytoplasm, Cytoskeleton, Membrane

Pathology & Biotechⁱ

Mutagenesis

Feature key	Position(s)	DescriptionActions	Length
Mutagenesisⁱ	75	T → A: Decreased kinase activity. Reduced binding of S100B. 1 Publication	1
Mutagenesisⁱ	119	K → A: Loss of autophosphorylation and kinase activity. 1 Publication	1
Mutagenesisⁱ	282	S → A: Loss of autophosphorylation and kinase activity. 1 Publication	1
Mutagenesisⁱ	442	T → A: Decreased kinase activity. 1 Publication	1

Organism-specific databases

DisGeNET More...DisGeNETⁱ	23012
Open Targets More...OpenTargetsⁱ	ENSG00000211455
PharmGKBⁱ	PA38252

Chemistry databases

ChEMBLⁱ	CHEMBL4851

ChEMBLⁱ

CHEMBL4851

Polymorphism and mutation databases

BioMutaⁱ	STK38L
DMDMⁱ	56749668

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Initiator methionineⁱ		Removed1 Publication
ChainⁱPRO_0000086720	2 – 464	Serine/threonine-protein kinase 38-likeAdd BLAST		463

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Modified residueⁱ	2	N-acetylalanine1 Publication	1
Modified residueⁱ	75	Phosphothreonine1 Publication	1
Modified residueⁱ	282	Phosphoserine; by autocatalysis1 Publication	1
Modified residueⁱ	442	Phosphothreonine; by STK24/MST32 Publications	1

Keywords - PTMⁱ

Acetylation, Phosphoprotein

Proteomic databases

EPDⁱ	Q9Y2H1
PaxDbⁱ	Q9Y2H1
PeptideAtlas More...PeptideAtlasⁱ	Q9Y2H1
PRIDEⁱ	Q9Y2H1
ProteomicsDBⁱ	85780

PTM databases

iPTMnetⁱ	Q9Y2H1
PhosphoSitePlusⁱ	Q9Y2H1

Expressionⁱ

Tissue specificityⁱ

Ubiquitously expressed with highest levels observed in the thymus.1 Publication

Gene expression databases

Bgeeⁱ	ENSG00000211455 Expressed in 228 organ(s), highest expression level in thoracic aorta
CleanExⁱ	HS_STK38L
ExpressionAtlasⁱ	Q9Y2H1 baseline and differential
Genevisibleⁱ	Q9Y2H1 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA038623 HPA051324

HPAⁱ

HPA038623
HPA051324

Interactionⁱ

Subunit structureⁱ

Homodimeric S100B binds two molecules of STK38L. Interacts with MICAL1; leading to inhibit the protein kinase activity by antagonizing activation by MST1/STK4 (By similarity). Interacts with MOB1 and MOB2.By similarity2 Publications

Binary interactionsⁱ

With	Entry	#Exp.	IntAct
CDC37	Q16543	2	EBI-991501,EBI-295634
MOB1A	Q9H8S9	4	EBI-991501,EBI-748229
MOB2	Q70IA6	4	EBI-991501,EBI-2558739

GO - Molecular functionⁱ

actin binding Source: UniProtKB-KW

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGridⁱ	116654, 27 interactors
IntActⁱ	Q9Y2H1, 7 interactors
Molecular INTeraction database More...MINTⁱ	Q9Y2H1
STRINGⁱ	9606.ENSP00000373684

Chemistry databases

BindingDBⁱ

Q9Y2H1

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q9Y2H1
SMRⁱ	Q9Y2H1
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Domainⁱ	90 – 383	Protein kinasePROSITE-ProRule annotationAdd BLAST		294
Domainⁱ	384 – 453	AGC-kinase C-terminalAdd BLAST		70

Region

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Regionⁱ	63 – 88	S100B bindingBy similarityAdd BLAST		26

Sequence similaritiesⁱ

Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family.Curated

Phylogenomic databases

eggNOGⁱ	KOG0605 Eukaryota ENOG410XQC0 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00760000118994
HOGENOMⁱ	HOG000233033
HOVERGENⁱ	HBG104247
InParanoidⁱ	Q9Y2H1
KEGG Orthology (KO) More...KOⁱ	K08790
OMAⁱ	NAIHLTM
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G028J
PhylomeDBⁱ	Q9Y2H1
TreeFamⁱ	TF105337

Family and domain databases

InterProⁱ	View protein in InterPro IPR000961 AGC-kinase_C IPR011009 Kinase-like_dom_sf IPR017892 Pkinase_C IPR000719 Prot_kinase_dom IPR017441 Protein_kinase_ATP_BS IPR008271 Ser/Thr_kinase_AS
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00069 Pkinase, 1 hit PF00433 Pkinase_C, 1 hit
SMARTⁱ	View protein in SMART SM00133 S_TK_X, 1 hit SM00220 S_TKc, 1 hit
SUPFAMⁱ	SSF56112 SSF56112, 2 hits
PROSITEⁱ	View protein in PROSITE PS51285 AGC_KINASE_CTER, 1 hit PS00107 PROTEIN_KINASE_ATP, 1 hit PS50011 PROTEIN_KINASE_DOM, 1 hit PS00108 PROTEIN_KINASE_ST, 1 hit

Sequences (2+)ⁱ

Sequence statusⁱ: Complete.

Sequence processingⁱ: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsⁱ produced by alternative splicing. Align Add to basket

This entry has 2 described isoforms and 7 potential isoforms that are computationally mapped.Show all Align All

Isoform 1 (identifier: Q9Y2H1-1) [UniParc]FASTA Add to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAMTAGTTTT FPMSNHTRER VTVAKLTLEN FYSNLILQHE ERETRQKKLE 
        60         70         80         90        100
VAMEEEGLAD EEKKLRRSQH ARKETEFLRL KRTRLGLDDF ESLKVIGRGA 
       110        120        130        140        150
FGEVRLVQKK DTGHIYAMKI LRKSDMLEKE QVAHIRAERD ILVEADGAWV 
       160        170        180        190        200
VKMFYSFQDK RNLYLIMEFL PGGDMMTLLM KKDTLTEEET QFYISETVLA 
       210        220        230        240        250
IDAIHQLGFI HRDIKPDNLL LDAKGHVKLS DFGLCTGLKK AHRTEFYRNL 
       260        270        280        290        300
THNPPSDFSF QNMNSKRKAE TWKKNRRQLA YSTVGTPDYI APEVFMQTGY 
       310        320        330        340        350
NKLCDWWSLG VIMYEMLIGY PPFCSETPQE TYRKVMNWKE TLVFPPEVPI 
       360        370        380        390        400
SEKAKDLILR FCIDSENRIG NSGVEEIKGH PFFEGVDWEH IRERPAAIPI 
       410        420        430        440        450
EIKSIDDTSN FDDFPESDIL QPVPNTTEPD YKSKDWVFLN YTYKRFEGLT 
       460 
QRGSIPTYMK AGKL

Length:464

Mass (Da):54,003

Last modified:December 21, 2004 - v3

Checksum:ⁱ71347E80BC3ADCB3

GO

Isoform 2 (identifier: Q9Y2H1-2) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
1-52: Missing.
62-102: Missing.

« Hide

        10         20         30         40         50
MEEEGLADEE VRLVQKKDTG HIYAMKILRK SDMLEKEQVA HIRAERDILV 
        60         70         80         90        100
EADGAWVVKM FYSFQDKRNL YLIMEFLPGG DMMTLLMKKD TLTEEETQFY 
       110        120        130        140        150
ISETVLAIDA IHQLGFIHRD IKPDNLLLDA KGHVKLSDFG LCTGLKKAHR 
       160        170        180        190        200
TEFYRNLTHN PPSDFSFQNM NSKRKAETWK KNRRQLAYST VGTPDYIAPE 
       210        220        230        240        250
VFMQTGYNKL CDWWSLGVIM YEMLIGYPPF CSETPQETYR KVMNWKETLV 
       260        270        280        290        300
FPPEVPISEK AKDLILRFCI DSENRIGNSG VEEIKGHPFF EGVDWEHIRE 
       310        320        330        340        350
RPAAIPIEIK SIDDTSNFDD FPESDILQPV PNTTEPDYKS KDWVFLNYTY 
       360        370 
KRFEGLTQRG SIPTYMKAGK L

Note: No experimental confirmation available.

Show »

Length:371

Mass (Da):43,170

Checksum:ⁱA8E29D3ED6CE7959

GO

Computationally mapped potential isoform sequencesⁱ

There are 7 potential isoforms mapped to this entry.BLAST Align Show all Add to basket

Entry	Entry name	Protein names	Gene names	Length	Annotation

F5GY51	F5GY51_HUMAN	Serine/threonine-protein kinase 38-... Serine/threonine-protein kinase 38-like	STK38L	131	Annotation score:
F5H7Z3	F5H7Z3_HUMAN	Serine/threonine-protein kinase 38-... Serine/threonine-protein kinase 38-like	STK38L	94	Annotation score:
H0YGN4	H0YGN4_HUMAN	Serine/threonine-protein kinase 38-... Serine/threonine-protein kinase 38-like	STK38L	87	Annotation score:
I3L0D0	I3L0D0_HUMAN	Serine/threonine-protein kinase 38-... Serine/threonine-protein kinase 38-like	STK38L	89	Annotation score:
F5H277	F5H277_HUMAN	Serine/threonine-protein kinase 38-... Serine/threonine-protein kinase 38-like	STK38L	213	Annotation score:
F5H0V1	F5H0V1_HUMAN	Serine/threonine-protein kinase 38-... Serine/threonine-protein kinase 38-like	STK38L	64	Annotation score:
F5H5E6	F5H5E6_HUMAN	Serine/threonine-protein kinase 38-... Serine/threonine-protein kinase 38-like	STK38L	56	Annotation score:

Natural variant

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Natural variantⁱVAR_041199	99	G → A in a aLL TEL/AML1+ sample; somatic mutation. 1 Publication		1

Alternative sequence

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Alternative sequenceⁱVSP_056233	1 – 52	Missing in isoform 2. 1 PublicationAdd BLAST		52
Alternative sequenceⁱVSP_056234	62 – 102	Missing in isoform 2. 1 PublicationAdd BLAST		41

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AB023182 mRNA Translation: BAA76809.2 AK291055 mRNA Translation: BAF83744.1 AK304755 mRNA Translation: BAG65510.1 AC092827 Genomic DNA No translation available. AC092829 Genomic DNA No translation available. CH471094 Genomic DNA Translation: EAW96549.1 BC028603 mRNA Translation: AAH28603.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS31761.1 [Q9Y2H1-1]
NCBI Reference Sequences More...RefSeqⁱ	NP_055815.1, NM_015000.3 [Q9Y2H1-1] XP_006719121.1, XM_006719058.3 [Q9Y2H1-1] XP_011518915.1, XM_011520613.2 [Q9Y2H1-2] XP_016874525.1, XM_017019036.1
UniGeneⁱ	Hs.184523

Genome annotation databases

Ensemblⁱ	ENST00000389032; ENSP00000373684; ENSG00000211455 [Q9Y2H1-1]
GeneIDⁱ	23012
KEGGⁱ	hsa:23012
UCSC genome browser More...UCSCⁱ	uc001rhr.4 human [Q9Y2H1-1]

Keywords - Coding sequence diversityⁱ

Alternative splicing, Polymorphism

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
Q9Y2H1	Non-specific serine/threonine protein kinase		PANTR		464	UniRef100_Q9Y2H1
Non-specific serine/threonine protein kinase		PANPA		464
Non-specific serine/threonine protein kinase		GORGO		464
UPI0000E23248		HUMAN		412
UPI0004F0A729		PANPA		470
Q9Y2H1-2	STK38L isoform 7 (Fragment)		PANTR		214	UniRef100_Q9Y2H1-2
Serine/threonine-protein kinase 38-like (Fragment)		HUMAN		213
UPI000041BE92		HUMAN		423
UPI0005124FFE		PANTR		429

Protein	Similar proteins		Species	Score	Length	Source
Q9Y2H1	Serine/threonine-protein kinase 38-like		MOUSE		464	UniRef90_Q9Y2H1
Non-specific serine/threonine protein kinase		PANTR		464
Non-specific serine/threonine protein kinase		PANPA		464
Non-specific serine/threonine protein kinase		GORGO		464
Non-specific serine/threonine protein kinase		PIG		520
+306
Q9Y2H1-2	STK38L isoform 7 (Fragment)		PANTR		214	UniRef90_Q9Y2H1-2
Serine/threonine-protein kinase 38-like (Fragment)		HUMAN		213
Non-specific serine/threonine protein kinase		TAEGU		363
STK38L isoform 3 (Fragment)		PONAB		214
UPI000809AE6A		Cebus capucinus imitator		423
+8

Protein	Similar proteins		Species	Score	Length	Source
Q9Y2H1	Serine/threonine-protein kinase 38-like		MOUSE		464	UniRef50_Q9Y2H1
Non-specific serine/threonine protein kinase		PANTR		464
Non-specific serine/threonine protein kinase		PANPA		464
Non-specific serine/threonine protein kinase		GORGO		464
Non-specific serine/threonine protein kinase		PIG		520
+343
Q9Y2H1-2	STK38L isoform 7 (Fragment)		PANTR		214	UniRef50_Q9Y2H1-2
Serine/threonine-protein kinase 38-like (Fragment)		HUMAN		213
Non-specific serine/threonine protein kinase		TAEGU		363
STK38L isoform 3 (Fragment)		PONAB		214
Chromosome undetermined SCAF7253, whole genome shotgun sequence (Fragment)		TETNG		515
+11

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AB023182 mRNA Translation: BAA76809.2 AK291055 mRNA Translation: BAF83744.1 AK304755 mRNA Translation: BAG65510.1 AC092827 Genomic DNA No translation available. AC092829 Genomic DNA No translation available. CH471094 Genomic DNA Translation: EAW96549.1 BC028603 mRNA Translation: AAH28603.1
CCDSⁱ	CCDS31761.1 [Q9Y2H1-1]
RefSeqⁱ	NP_055815.1, NM_015000.3 [Q9Y2H1-1] XP_006719121.1, XM_006719058.3 [Q9Y2H1-1] XP_011518915.1, XM_011520613.2 [Q9Y2H1-2] XP_016874525.1, XM_017019036.1
UniGeneⁱ	Hs.184523

3D structure databases

Select the link destinations: Protein Data Bank Europe More...PDBeⁱ Protein Data Bank RCSB More...RCSB PDBⁱ Protein Data Bank Japan More...PDBjⁱ Links Updated	PDB entry	Method	Resolution (Å)	Chain	Positions	PDBsum
	5XQZ	X-ray	2.10	C/D	25-87	[»]
ProteinModelPortalⁱ	Q9Y2H1
SMRⁱ	Q9Y2H1
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	116654, 27 interactors
IntActⁱ	Q9Y2H1, 7 interactors
MINTⁱ	Q9Y2H1
STRINGⁱ	9606.ENSP00000373684

Chemistry databases

BindingDBⁱ	Q9Y2H1
ChEMBLⁱ	CHEMBL4851

PTM databases

iPTMnetⁱ	Q9Y2H1
PhosphoSitePlusⁱ	Q9Y2H1

Polymorphism and mutation databases

BioMutaⁱ	STK38L
DMDMⁱ	56749668

Proteomic databases

EPDⁱ	Q9Y2H1
PaxDbⁱ	Q9Y2H1
PeptideAtlasⁱ	Q9Y2H1
PRIDEⁱ	Q9Y2H1
ProteomicsDBⁱ	85780

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	23012
Structural Biology Knowledgebase	Search...

Genome annotation databases

Ensemblⁱ	ENST00000389032; ENSP00000373684; ENSG00000211455 [Q9Y2H1-1]
GeneIDⁱ	23012
KEGGⁱ	hsa:23012
UCSCⁱ	uc001rhr.4 human [Q9Y2H1-1]

Organism-specific databases

CTDⁱ	23012
DisGeNETⁱ	23012
EuPathDBⁱ	HostDB:ENSG00000211455.7
GeneCardsⁱ	STK38L
HGNCⁱ	HGNC:17848 STK38L
HPAⁱ	HPA038623 HPA051324
MIMⁱ	615836 gene
neXtProtⁱ	NX_Q9Y2H1
OpenTargetsⁱ	ENSG00000211455
PharmGKBⁱ	PA38252
HUGEⁱ	Search...
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG0605 Eukaryota ENOG410XQC0 LUCA
GeneTreeⁱ	ENSGT00760000118994
HOGENOMⁱ	HOG000233033
HOVERGENⁱ	HBG104247
InParanoidⁱ	Q9Y2H1
KOⁱ	K08790
OMAⁱ	NAIHLTM
OrthoDBⁱ	EOG091G028J
PhylomeDBⁱ	Q9Y2H1
TreeFamⁱ	TF105337

Enzyme and pathway databases

SignaLinkⁱ	Q9Y2H1
SIGNORⁱ	Q9Y2H1

Miscellaneous databases

ChiTaRSⁱ	STK38L human
GeneWikiⁱ	STK38L
GenomeRNAiⁱ	23012
Protein Ontology More...PROⁱ	PR:Q9Y2H1
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000211455 Expressed in 228 organ(s), highest expression level in thoracic aorta
CleanExⁱ	HS_STK38L
ExpressionAtlasⁱ	Q9Y2H1 baseline and differential
Genevisibleⁱ	Q9Y2H1 HS

Family and domain databases

InterProⁱ	View protein in InterPro IPR000961 AGC-kinase_C IPR011009 Kinase-like_dom_sf IPR017892 Pkinase_C IPR000719 Prot_kinase_dom IPR017441 Protein_kinase_ATP_BS IPR008271 Ser/Thr_kinase_AS
Pfamⁱ	View protein in Pfam PF00069 Pkinase, 1 hit PF00433 Pkinase_C, 1 hit
SMARTⁱ	View protein in SMART SM00133 S_TK_X, 1 hit SM00220 S_TKc, 1 hit
SUPFAMⁱ	SSF56112 SSF56112, 2 hits
PROSITEⁱ	View protein in PROSITE PS51285 AGC_KINASE_CTER, 1 hit PS00107 PROTEIN_KINASE_ATP, 1 hit PS50011 PROTEIN_KINASE_DOM, 1 hit PS00108 PROTEIN_KINASE_ST, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	ST38L_HUMAN
Accessionⁱ	Q9Y2H1Primary (citable) accession number: Q9Y2H1 Secondary accession number(s): A8K4U0, B4E3J8, Q8TBX7
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	December 21, 2004
	Last sequence update:	December 21, 2004
	Last modified:	October 10, 2018
	This is version 166 of the entry and version 3 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

PDB cross-references
Index of Protein Data Bank (PDB) cross-references
SIMILARITY comments
Index of protein domains and families
Human chromosome 12
Human chromosome 12: entries, gene names and cross-references to MIM
Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations
Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
Human and mouse protein kinases
Human and mouse protein kinases: classification and index

UniProtKB

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UniProtKB - Q9Y2H1 (ST38L_HUMAN)

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Serine/threonine-protein kinase 38-like

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Sites

Regions

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Cytoskeleton

Other locations

Cytoskeleton

Cytosol

Other locations

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Organism-specific databases

Chemistry databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

Chemistry databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Region

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

Family and domain databases

Natural variant

Alternative sequence

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

Chemistry databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ