UniProtKB - Q9Y2H0 (DLGP4_HUMAN)
Protein
Disks large-associated protein 4
Gene
DLGAP4
Organism
Homo sapiens (Human)
Status
Functioni
May play a role in the molecular organization of synapses and neuronal cell signaling. Could be an adapter protein linking ion channel to the subsynaptic cytoskeleton. May induce enrichment of PSD-95/SAP90 at the plasma membrane.
GO - Molecular functioni
- molecular adaptor activity Source: GO_Central
GO - Biological processi
- regulation of postsynaptic neurotransmitter receptor activity Source: GO_Central
- signaling Source: InterPro
Enzyme and pathway databases
PathwayCommonsi | Q9Y2H0 |
Reactomei | R-HSA-6794361, Neurexins and neuroligins |
Names & Taxonomyi
Protein namesi | Recommended name: Disks large-associated protein 4Short name: DAP-4 Alternative name(s): PSD-95/SAP90-binding protein 4 SAP90/PSD-95-associated protein 4 Short name: SAPAP-4 |
Gene namesi | Name:DLGAP4 Synonyms:DAP4, KIAA0964, SAPAP4 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:24476, DLGAP4 |
MIMi | 616191, gene |
neXtProti | NX_Q9Y2H0 |
VEuPathDBi | HostDB:ENSG00000080845.17 |
Subcellular locationi
Other locations
- Membrane By similarity; Peripheral membrane protein By similarity
Plasma Membrane
- plasma membrane Source: Reactome
Other locations
- cholinergic synapse Source: Ensembl
- glutamatergic synapse Source: GO_Central
- neuromuscular junction Source: Ensembl
- postsynaptic specialization Source: GO_Central
Keywords - Cellular componenti
MembranePathology & Biotechi
Organism-specific databases
DisGeNETi | 22839 |
OpenTargetsi | ENSG00000080845 |
PharmGKBi | PA134891458 |
Miscellaneous databases
Pharosi | Q9Y2H0, Tbio |
Genetic variation databases
BioMutai | DLGAP4 |
DMDMi | 205831580 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000174297 | 1 – 992 | Disks large-associated protein 4Add BLAST | 992 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 206 | PhosphoserineBy similarity | 1 | |
Modified residuei | 207 | PhosphoserineBy similarity | 1 | |
Modified residuei | 291 | Omega-N-methylarginineBy similarity | 1 | |
Modified residuei | 378 | PhosphoserineBy similarity | 1 | |
Modified residuei | 381 | PhosphoserineBy similarity | 1 | |
Modified residuei | 388 | PhosphoserineBy similarity | 1 | |
Modified residuei | 405 | PhosphoserineBy similarity | 1 | |
Modified residuei | 415 | PhosphoserineBy similarity | 1 | |
Modified residuei | 421 | PhosphoserineBy similarity | 1 | |
Modified residuei | 580 | PhosphoserineBy similarity | 1 | |
Modified residuei | 581 | PhosphoserineBy similarity | 1 | |
Modified residuei | 609 | PhosphoserineBy similarity | 1 | |
Modified residuei | 611 | PhosphoserineBy similarity | 1 | |
Modified residuei | 665 | PhosphoserineCombined sources | 1 | |
Modified residuei | 744 | PhosphoserineCombined sources | 1 | |
Modified residuei | 915 | PhosphothreonineCombined sources | 1 | |
Modified residuei | 973 | PhosphoserineCombined sources | 1 |
Keywords - PTMi
Methylation, PhosphoproteinProteomic databases
EPDi | Q9Y2H0 |
jPOSTi | Q9Y2H0 |
MassIVEi | Q9Y2H0 |
MaxQBi | Q9Y2H0 |
PaxDbi | Q9Y2H0 |
PeptideAtlasi | Q9Y2H0 |
PRIDEi | Q9Y2H0 |
ProteomicsDBi | 85777 [Q9Y2H0-2] 85778 [Q9Y2H0-1] 85779 [Q9Y2H0-3] |
PTM databases
iPTMneti | Q9Y2H0 |
PhosphoSitePlusi | Q9Y2H0 |
SwissPalmi | Q9Y2H0 |
Expressioni
Gene expression databases
Bgeei | ENSG00000080845, Expressed in cortical plate and 226 other tissues |
ExpressionAtlasi | Q9Y2H0, baseline and differential |
Genevisiblei | Q9Y2H0, HS |
Organism-specific databases
HPAi | ENSG00000080845, Low tissue specificity |
Interactioni
Subunit structurei
Interacts with DLG1 and DLG4/PSD-95.
By similarityBinary interactionsi
Hide detailsQ9Y2H0
With | #Exp. | IntAct |
---|---|---|
BIN1 [O00499] | 4 | EBI-722139,EBI-719094 |
GRB2 [P62993] | 2 | EBI-722139,EBI-401755 |
NCK1 [P16333] | 5 | EBI-722139,EBI-389883 |
PIK3R1 [P27986] | 2 | EBI-722139,EBI-79464 |
Isoform 2 [Q9Y2H0-1]
Protein-protein interaction databases
BioGRIDi | 116513, 43 interactors |
IntActi | Q9Y2H0, 42 interactors |
MINTi | Q9Y2H0 |
STRINGi | 9606.ENSP00000363023 |
Miscellaneous databases
RNActi | Q9Y2H0, protein |
Family & Domainsi
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 267 – 274 | Poly-Pro | 8 |
Sequence similaritiesi
Belongs to the SAPAP family.Curated
Phylogenomic databases
eggNOGi | KOG3971, Eukaryota |
GeneTreei | ENSGT00940000155308 |
HOGENOMi | CLU_010880_0_0_1 |
InParanoidi | Q9Y2H0 |
OMAi | QFPRGEP |
OrthoDBi | 285447at2759 |
PhylomeDBi | Q9Y2H0 |
TreeFami | TF321382 |
Family and domain databases
InterProi | View protein in InterPro IPR030527, DLGAP4 IPR005026, SAPAP |
PANTHERi | PTHR12353, PTHR12353, 1 hit PTHR12353:SF19, PTHR12353:SF19, 1 hit |
Pfami | View protein in Pfam PF03359, GKAP, 1 hit |
s (3+)i Sequence
Sequence statusi: Complete.
This entry describes 3 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 3 described isoforms and 4 potential isoforms that are computationally mapped.Show allAlign All
Isoform 1 (identifier: Q9Y2H0-2) [UniParc]FASTAAdd to basket
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MKGLGDSRPR HLSDSLDPPH EPLFAGTDRN PYLLSPTEAF AREARFPGQN
60 70 80 90 100
TLPGDGLFPL NNQLPPPSST FPRIHYNSHF EVPEESPFPS HAQATKINRL
110 120 130 140 150
PANLLDQFEK QLPIHRDGFS TLQFPRGEAK ARGESPGRIR HLVHSVQRLF
160 170 180 190 200
FTKAPSLEGT AGKVGGNGSK KGGMEDGKGR RAKSKERAKA GEPKRRSRSN
210 220 230 240 250
ISGWWSSDDN LDGEAGAFRS SGPASGLMTL GRQAERSQPR YFMHAYNTIS
260 270 280 290 300
GHMLKTTKNN TTELTAPPPP PAPPATCPSL GVGTDTNYVK RGSWSTLTLS
310 320 330 340 350
HAHEVCQKTS ATLDKSLLKS KSCHQGLAYH YLQVPGGGGE WSTTLLSPRE
360 370 380 390 400
TDAAAEGPIP CRRMRSGSYI KAMGDEDSDE SGGSPKPSPK TAARRQSYLR
410 420 430 440 450
ATQQSLGEQS NPRRSLDRLD SVDMLLPSKC PSWEEDYTPV SDSLNDSSCI
460 470 480 490 500
SQIFGQASLI PQLFGHEQQV REAELSDQYE AACESACSEA ESTAAETLDL
510 520 530 540 550
PLPSYFRSRS HSYLRAIQAG CSQEEDSVSL QSLSPPPSTG SLSNSRTLPS
560 570 580 590 600
SSCLVAYKKT PPPVPPRTTS KPFISVTVQS STESAQDTYL DSQDHKSEVT
610 620 630 640 650
SQSGLSNSSD SLDSSTRPPS VTRGGVAPAP EAPEPPPKHA ALKSEQGTLT
660 670 680 690 700
SSESHPEAAP KRKLSSIGIQ VDCIQPVPKE EPSPATKFQS IGVQVEDDWR
710 720 730 740 750
SSVPSHSMSS RRDTDSDTQD ANDSSCKSSE RSLPDCTPHP NSISIDAGPR
760 770 780 790 800
QAPKIAQIKR NLSYGDNSDP ALEASSLPPP DPWLETSSSS PAEPAQPGAC
810 820 830 840 850
RRDGYWFLKL LQAETERLEG WCCQMDKETK ENNLSEEVLG KVLSAVGSAQ
860 870 880 890 900
LLMSQKFQQF RGLCEQNLNP DANPRPTAQD LAGFWDLLQL SIEDISMKFD
910 920 930 940 950
ELYHLKANSW QLVETPEKRK EEKKPPPPVP KKPAKSKPAV SRDKASDASD
960 970 980 990
KQRQEARKRL LAAKRAASVR QNSATESADS IEIYVPEAQT RL
Computationally mapped potential isoform sequencesi
There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketA0A0B4J2C2 | A0A0B4J2C2_HUMAN | Discs, large (Drosophila) homolog-a... | DLGAP4 hCG_2020065 | 285 | Annotation score: | ||
F8WF49 | F8WF49_HUMAN | Disks large-associated protein 4 | DLGAP4 | 244 | Annotation score: | ||
A0A087X246 | A0A087X246_HUMAN | Disks large-associated protein 4 | DLGAP4 | 125 | Annotation score: | ||
A0A087WWE6 | A0A087WWE6_HUMAN | Disks large-associated protein 4 | DLGAP4 | 46 | Annotation score: |
Sequence cautioni
The sequence BAA76808 differs from that shown. Reason: Erroneous initiation.Curated
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 229 | T → I in BAA76808 (PubMed:10231032).Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_057716 | 486 | A → T. Corresponds to variant dbSNP:rs6019652Ensembl. | 1 | |
Natural variantiVAR_057717 | 861 | R → Q. Corresponds to variant dbSNP:rs2275807Ensembl. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_034910 | 1 – 539 | Missing in isoform 3. 1 PublicationAdd BLAST | 539 | |
Alternative sequenceiVSP_034911 | 540 – 550 | GSLSNSRTLPS → MALCLELLKQC in isoform 3. 1 PublicationAdd BLAST | 11 | |
Alternative sequenceiVSP_006013 | 671 – 700 | VDCIQ…EDDWR → ERTRRNGSHLSEDNGPKAID VMAPSSE in isoform 2. 1 PublicationAdd BLAST | 30 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AB023181 mRNA Translation: BAA76808.2 Different initiation. AL390374 Genomic DNA No translation available. AL050318 Genomic DNA No translation available. CH471077 Genomic DNA Translation: EAW76140.1 CH471077 Genomic DNA Translation: EAW76135.1 CH471077 Genomic DNA Translation: EAW76136.1 BC108706 mRNA Translation: AAI08707.1 BC153874 mRNA Translation: AAI53875.1 |
CCDSi | CCDS13274.1 [Q9Y2H0-1] CCDS13275.1 [Q9Y2H0-3] |
RefSeqi | NP_001035951.1, NM_001042486.3 NP_055717.2, NM_014902.5 [Q9Y2H0-1] NP_892118.1, NM_183006.3 [Q9Y2H0-3] XP_011526990.1, XM_011528688.2 |
Genome annotation databases
Ensembli | ENST00000339266; ENSP00000341633; ENSG00000080845 [Q9Y2H0-2] ENST00000340491; ENSP00000345700; ENSG00000080845 [Q9Y2H0-3] ENST00000373907; ENSP00000363014; ENSG00000080845 [Q9Y2H0-2] ENST00000373913; ENSP00000363023; ENSG00000080845 [Q9Y2H0-1] ENST00000401952; ENSP00000384954; ENSG00000080845 [Q9Y2H0-1] |
GeneIDi | 22839 |
KEGGi | hsa:22839 |
UCSCi | uc002xff.4, human [Q9Y2H0-2] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AB023181 mRNA Translation: BAA76808.2 Different initiation. AL390374 Genomic DNA No translation available. AL050318 Genomic DNA No translation available. CH471077 Genomic DNA Translation: EAW76140.1 CH471077 Genomic DNA Translation: EAW76135.1 CH471077 Genomic DNA Translation: EAW76136.1 BC108706 mRNA Translation: AAI08707.1 BC153874 mRNA Translation: AAI53875.1 |
CCDSi | CCDS13274.1 [Q9Y2H0-1] CCDS13275.1 [Q9Y2H0-3] |
RefSeqi | NP_001035951.1, NM_001042486.3 NP_055717.2, NM_014902.5 [Q9Y2H0-1] NP_892118.1, NM_183006.3 [Q9Y2H0-3] XP_011526990.1, XM_011528688.2 |
3D structure databases
SMRi | Q9Y2H0 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 116513, 43 interactors |
IntActi | Q9Y2H0, 42 interactors |
MINTi | Q9Y2H0 |
STRINGi | 9606.ENSP00000363023 |
PTM databases
iPTMneti | Q9Y2H0 |
PhosphoSitePlusi | Q9Y2H0 |
SwissPalmi | Q9Y2H0 |
Genetic variation databases
BioMutai | DLGAP4 |
DMDMi | 205831580 |
Proteomic databases
EPDi | Q9Y2H0 |
jPOSTi | Q9Y2H0 |
MassIVEi | Q9Y2H0 |
MaxQBi | Q9Y2H0 |
PaxDbi | Q9Y2H0 |
PeptideAtlasi | Q9Y2H0 |
PRIDEi | Q9Y2H0 |
ProteomicsDBi | 85777 [Q9Y2H0-2] 85778 [Q9Y2H0-1] 85779 [Q9Y2H0-3] |
Protocols and materials databases
Antibodypediai | 26505, 121 antibodies |
DNASUi | 22839 |
Genome annotation databases
Ensembli | ENST00000339266; ENSP00000341633; ENSG00000080845 [Q9Y2H0-2] ENST00000340491; ENSP00000345700; ENSG00000080845 [Q9Y2H0-3] ENST00000373907; ENSP00000363014; ENSG00000080845 [Q9Y2H0-2] ENST00000373913; ENSP00000363023; ENSG00000080845 [Q9Y2H0-1] ENST00000401952; ENSP00000384954; ENSG00000080845 [Q9Y2H0-1] |
GeneIDi | 22839 |
KEGGi | hsa:22839 |
UCSCi | uc002xff.4, human [Q9Y2H0-2] |
Organism-specific databases
CTDi | 22839 |
DisGeNETi | 22839 |
GeneCardsi | DLGAP4 |
HGNCi | HGNC:24476, DLGAP4 |
HPAi | ENSG00000080845, Low tissue specificity |
MIMi | 616191, gene |
neXtProti | NX_Q9Y2H0 |
OpenTargetsi | ENSG00000080845 |
PharmGKBi | PA134891458 |
VEuPathDBi | HostDB:ENSG00000080845.17 |
HUGEi | Search... |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG3971, Eukaryota |
GeneTreei | ENSGT00940000155308 |
HOGENOMi | CLU_010880_0_0_1 |
InParanoidi | Q9Y2H0 |
OMAi | QFPRGEP |
OrthoDBi | 285447at2759 |
PhylomeDBi | Q9Y2H0 |
TreeFami | TF321382 |
Enzyme and pathway databases
PathwayCommonsi | Q9Y2H0 |
Reactomei | R-HSA-6794361, Neurexins and neuroligins |
Miscellaneous databases
BioGRID-ORCSi | 22839, 7 hits in 877 CRISPR screens |
ChiTaRSi | DLGAP4, human |
GeneWikii | DLGAP4 |
GenomeRNAii | 22839 |
Pharosi | Q9Y2H0, Tbio |
PROi | PR:Q9Y2H0 |
RNActi | Q9Y2H0, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000080845, Expressed in cortical plate and 226 other tissues |
ExpressionAtlasi | Q9Y2H0, baseline and differential |
Genevisiblei | Q9Y2H0, HS |
Family and domain databases
InterProi | View protein in InterPro IPR030527, DLGAP4 IPR005026, SAPAP |
PANTHERi | PTHR12353, PTHR12353, 1 hit PTHR12353:SF19, PTHR12353:SF19, 1 hit |
Pfami | View protein in Pfam PF03359, GKAP, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | DLGP4_HUMAN | |
Accessioni | Q9Y2H0Primary (citable) accession number: Q9Y2H0 Secondary accession number(s): E1P5T5 Q9H1L7 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | September 26, 2001 |
Last sequence update: | July 22, 2008 | |
Last modified: | February 10, 2021 | |
This is version 170 of the entry and version 3 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families - Human chromosome 20
Human chromosome 20: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants