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UniProtKB - Q9Y2H0 (DLGP4_HUMAN)

Protein

Disks large-associated protein 4

Gene

DLGAP4

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May play a role in the molecular organization of synapses and neuronal cell signaling. Could be an adapter protein linking ion channel to the subsynaptic cytoskeleton. May induce enrichment of PSD-95/SAP90 at the plasma membrane.

GO - Biological processi

View the complete GO annotation on QuickGO ...

Enzyme and pathway databases

ReactomeiR-HSA-6794361 Neurexins and neuroligins

Names & Taxonomyi

Protein namesi
Recommended name:
Disks large-associated protein 4
Short name:
DAP-4
Alternative name(s):
PSD-95/SAP90-binding protein 4
SAP90/PSD-95-associated protein 4
Short name:
SAPAP-4
Gene namesi
Name:DLGAP4
Synonyms:DAP4, KIAA0964, SAPAP4
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
Proteomesi
  • UP000005640 Componenti: Chromosome 20

Organism-specific databases

EuPathDBiHostDB:ENSG00000080845.17
HGNCiHGNC:24476 DLGAP4
MIMi616191 gene
neXtProtiNX_Q9Y2H0

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi22839
OpenTargetsiENSG00000080845
PharmGKBiPA134891458

Polymorphism and mutation databases

BioMutaiDLGAP4
DMDMi205831580

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001742971 – 992Disks large-associated protein 4Add BLAST992

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei206PhosphoserineBy similarity1
Modified residuei207PhosphoserineBy similarity1
Modified residuei291Omega-N-methylarginineBy similarity1
Modified residuei378PhosphoserineBy similarity1
Modified residuei381PhosphoserineBy similarity1
Modified residuei388PhosphoserineBy similarity1
Modified residuei405PhosphoserineBy similarity1
Modified residuei415PhosphoserineBy similarity1
Modified residuei421PhosphoserineBy similarity1
Modified residuei580PhosphoserineBy similarity1
Modified residuei581PhosphoserineBy similarity1
Modified residuei609PhosphoserineBy similarity1
Modified residuei611PhosphoserineBy similarity1
Modified residuei665PhosphoserineCombined sources1
Modified residuei744PhosphoserineCombined sources1
Modified residuei915PhosphothreonineCombined sources1
Modified residuei973PhosphoserineCombined sources1

Keywords - PTMi

Methylation, Phosphoprotein

Proteomic databases

EPDiQ9Y2H0
MaxQBiQ9Y2H0
PaxDbiQ9Y2H0
PeptideAtlasiQ9Y2H0
PRIDEiQ9Y2H0
ProteomicsDBi85777
85778 [Q9Y2H0-1]
85779 [Q9Y2H0-3]

PTM databases

iPTMnetiQ9Y2H0
PhosphoSitePlusiQ9Y2H0
SwissPalmiQ9Y2H0

Expressioni

Gene expression databases

BgeeiENSG00000080845 Expressed in 214 organ(s), highest expression level in esophagogastric junction muscularis propria
CleanExiHS_DLGAP4
ExpressionAtlasiQ9Y2H0 baseline and differential
GenevisibleiQ9Y2H0 HS

Organism-specific databases

HPAiHPA054105
HPA056378

Interactioni

Subunit structurei

Interacts with DLG1 and DLG4/PSD-95.By similarity

Binary interactionsi

Protein-protein interaction databases

BioGridi116513, 19 interactors
IntActiQ9Y2H0, 36 interactors
MINTiQ9Y2H0
STRINGi9606.ENSP00000363023

Structurei

3D structure databases

ProteinModelPortaliQ9Y2H0
SMRiQ9Y2H0
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi267 – 274Poly-Pro8

Sequence similaritiesi

Belongs to the SAPAP family.Curated

Phylogenomic databases

eggNOGiKOG3971 Eukaryota
ENOG4111JKV LUCA
GeneTreeiENSGT00550000074473
HOVERGENiHBG018957
InParanoidiQ9Y2H0
OMAiYIKRGSW
OrthoDBiEOG091G0J9O
PhylomeDBiQ9Y2H0
TreeFamiTF321382

Family and domain databases

InterProiView protein in InterPro
IPR030527 DLGAP4
IPR005026 SAPAP
PANTHERiPTHR12353 PTHR12353, 1 hit
PTHR12353:SF19 PTHR12353:SF19, 1 hit
PfamiView protein in Pfam
PF03359 GKAP, 1 hit

Sequences (3+)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 4 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q9Y2H0-2) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MKGLGDSRPR HLSDSLDPPH EPLFAGTDRN PYLLSPTEAF AREARFPGQN 
        60         70         80         90        100
TLPGDGLFPL NNQLPPPSST FPRIHYNSHF EVPEESPFPS HAQATKINRL 
       110        120        130        140        150
PANLLDQFEK QLPIHRDGFS TLQFPRGEAK ARGESPGRIR HLVHSVQRLF 
       160        170        180        190        200
FTKAPSLEGT AGKVGGNGSK KGGMEDGKGR RAKSKERAKA GEPKRRSRSN 
       210        220        230        240        250
ISGWWSSDDN LDGEAGAFRS SGPASGLMTL GRQAERSQPR YFMHAYNTIS 
       260        270        280        290        300
GHMLKTTKNN TTELTAPPPP PAPPATCPSL GVGTDTNYVK RGSWSTLTLS 
       310        320        330        340        350
HAHEVCQKTS ATLDKSLLKS KSCHQGLAYH YLQVPGGGGE WSTTLLSPRE 
       360        370        380        390        400
TDAAAEGPIP CRRMRSGSYI KAMGDEDSDE SGGSPKPSPK TAARRQSYLR 
       410        420        430        440        450
ATQQSLGEQS NPRRSLDRLD SVDMLLPSKC PSWEEDYTPV SDSLNDSSCI 
       460        470        480        490        500
SQIFGQASLI PQLFGHEQQV REAELSDQYE AACESACSEA ESTAAETLDL 
       510        520        530        540        550
PLPSYFRSRS HSYLRAIQAG CSQEEDSVSL QSLSPPPSTG SLSNSRTLPS 
       560        570        580        590        600
SSCLVAYKKT PPPVPPRTTS KPFISVTVQS STESAQDTYL DSQDHKSEVT 
       610        620        630        640        650
SQSGLSNSSD SLDSSTRPPS VTRGGVAPAP EAPEPPPKHA ALKSEQGTLT 
       660        670        680        690        700
SSESHPEAAP KRKLSSIGIQ VDCIQPVPKE EPSPATKFQS IGVQVEDDWR 
       710        720        730        740        750
SSVPSHSMSS RRDTDSDTQD ANDSSCKSSE RSLPDCTPHP NSISIDAGPR 
       760        770        780        790        800
QAPKIAQIKR NLSYGDNSDP ALEASSLPPP DPWLETSSSS PAEPAQPGAC 
       810        820        830        840        850
RRDGYWFLKL LQAETERLEG WCCQMDKETK ENNLSEEVLG KVLSAVGSAQ 
       860        870        880        890        900
LLMSQKFQQF RGLCEQNLNP DANPRPTAQD LAGFWDLLQL SIEDISMKFD 
       910        920        930        940        950
ELYHLKANSW QLVETPEKRK EEKKPPPPVP KKPAKSKPAV SRDKASDASD 
       960        970        980        990 
KQRQEARKRL LAAKRAASVR QNSATESADS IEIYVPEAQT RL
Length:992
Mass (Da):108,012
Last modified:July 22, 2008 - v3
Checksum:iF0EBFBE0DE1AC814
GO
Isoform 2 (identifier: Q9Y2H0-1) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     671-700: VDCIQPVPKEEPSPATKFQSIGVQVEDDWR → ERTRRNGSHLSEDNGPKAIDVMAPSSE

Show »
Length:989
Mass (Da):107,567
Checksum:iB2FD9A2103E052EB
GO
Isoform 3 (identifier: Q9Y2H0-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-539: Missing.
     540-550: GSLSNSRTLPS → MALCLELLKQC

Show »
Length:453
Mass (Da):49,478
Checksum:i877C20CA747800EB
GO

Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A0B4J2C2A0A0B4J2C2_HUMAN
Discs, large (Drosophila) homolog-a...
DLGAP4 hCG_2020065
285Annotation score:
F8WF49F8WF49_HUMAN
Disks large-associated protein 4
DLGAP4
244Annotation score:
A0A087X246A0A087X246_HUMAN
Disks large-associated protein 4
DLGAP4
125Annotation score:
A0A087WWE6A0A087WWE6_HUMAN
Disks large-associated protein 4
DLGAP4
46Annotation score:

Sequence cautioni

The sequence BAA76808 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti229T → I in BAA76808 (PubMed:10231032).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_057716486A → T. Corresponds to variant dbSNP:rs6019652Ensembl.1
Natural variantiVAR_057717861R → Q. Corresponds to variant dbSNP:rs2275807Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0349101 – 539Missing in isoform 3. 1 PublicationAdd BLAST539
Alternative sequenceiVSP_034911540 – 550GSLSNSRTLPS → MALCLELLKQC in isoform 3. 1 PublicationAdd BLAST11
Alternative sequenceiVSP_006013671 – 700VDCIQ…EDDWR → ERTRRNGSHLSEDNGPKAID VMAPSSE in isoform 2. 1 PublicationAdd BLAST30

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB023181 mRNA Translation: BAA76808.2 Different initiation.
AL390374 Genomic DNA No translation available.
AL050318 Genomic DNA No translation available.
CH471077 Genomic DNA Translation: EAW76140.1
CH471077 Genomic DNA Translation: EAW76135.1
CH471077 Genomic DNA Translation: EAW76136.1
BC108706 mRNA Translation: AAI08707.1
BC153874 mRNA Translation: AAI53875.1
CCDSiCCDS13274.1 [Q9Y2H0-1]
CCDS13275.1 [Q9Y2H0-3]
RefSeqiNP_001035951.1, NM_001042486.3
NP_055717.2, NM_014902.5 [Q9Y2H0-1]
NP_892118.1, NM_183006.3 [Q9Y2H0-3]
XP_011526990.1, XM_011528688.2 [Q9Y2H0-2]
UniGeneiHs.249600

Genome annotation databases

EnsembliENST00000339266; ENSP00000341633; ENSG00000080845 [Q9Y2H0-2]
ENST00000340491; ENSP00000345700; ENSG00000080845 [Q9Y2H0-3]
ENST00000373907; ENSP00000363014; ENSG00000080845 [Q9Y2H0-2]
ENST00000373913; ENSP00000363023; ENSG00000080845 [Q9Y2H0-1]
ENST00000401952; ENSP00000384954; ENSG00000080845 [Q9Y2H0-1]
GeneIDi22839
KEGGihsa:22839
UCSCiuc002xff.4 human [Q9Y2H0-2]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB023181 mRNA Translation: BAA76808.2 Different initiation.
AL390374 Genomic DNA No translation available.
AL050318 Genomic DNA No translation available.
CH471077 Genomic DNA Translation: EAW76140.1
CH471077 Genomic DNA Translation: EAW76135.1
CH471077 Genomic DNA Translation: EAW76136.1
BC108706 mRNA Translation: AAI08707.1
BC153874 mRNA Translation: AAI53875.1
CCDSiCCDS13274.1 [Q9Y2H0-1]
CCDS13275.1 [Q9Y2H0-3]
RefSeqiNP_001035951.1, NM_001042486.3
NP_055717.2, NM_014902.5 [Q9Y2H0-1]
NP_892118.1, NM_183006.3 [Q9Y2H0-3]
XP_011526990.1, XM_011528688.2 [Q9Y2H0-2]
UniGeneiHs.249600

3D structure databases

ProteinModelPortaliQ9Y2H0
SMRiQ9Y2H0
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi116513, 19 interactors
IntActiQ9Y2H0, 36 interactors
MINTiQ9Y2H0
STRINGi9606.ENSP00000363023

PTM databases

iPTMnetiQ9Y2H0
PhosphoSitePlusiQ9Y2H0
SwissPalmiQ9Y2H0

Polymorphism and mutation databases

BioMutaiDLGAP4
DMDMi205831580

Proteomic databases

EPDiQ9Y2H0
MaxQBiQ9Y2H0
PaxDbiQ9Y2H0
PeptideAtlasiQ9Y2H0
PRIDEiQ9Y2H0
ProteomicsDBi85777
85778 [Q9Y2H0-1]
85779 [Q9Y2H0-3]

Protocols and materials databases

DNASUi22839
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000339266; ENSP00000341633; ENSG00000080845 [Q9Y2H0-2]
ENST00000340491; ENSP00000345700; ENSG00000080845 [Q9Y2H0-3]
ENST00000373907; ENSP00000363014; ENSG00000080845 [Q9Y2H0-2]
ENST00000373913; ENSP00000363023; ENSG00000080845 [Q9Y2H0-1]
ENST00000401952; ENSP00000384954; ENSG00000080845 [Q9Y2H0-1]
GeneIDi22839
KEGGihsa:22839
UCSCiuc002xff.4 human [Q9Y2H0-2]

Organism-specific databases

CTDi22839
DisGeNETi22839
EuPathDBiHostDB:ENSG00000080845.17
GeneCardsiDLGAP4
HGNCiHGNC:24476 DLGAP4
HPAiHPA054105
HPA056378
MIMi616191 gene
neXtProtiNX_Q9Y2H0
OpenTargetsiENSG00000080845
PharmGKBiPA134891458
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3971 Eukaryota
ENOG4111JKV LUCA
GeneTreeiENSGT00550000074473
HOVERGENiHBG018957
InParanoidiQ9Y2H0
OMAiYIKRGSW
OrthoDBiEOG091G0J9O
PhylomeDBiQ9Y2H0
TreeFamiTF321382

Enzyme and pathway databases

ReactomeiR-HSA-6794361 Neurexins and neuroligins

Miscellaneous databases

ChiTaRSiDLGAP4 human
GeneWikiiDLGAP4
GenomeRNAii22839
PROiPR:Q9Y2H0
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000080845 Expressed in 214 organ(s), highest expression level in esophagogastric junction muscularis propria
CleanExiHS_DLGAP4
ExpressionAtlasiQ9Y2H0 baseline and differential
GenevisibleiQ9Y2H0 HS

Family and domain databases

InterProiView protein in InterPro
IPR030527 DLGAP4
IPR005026 SAPAP
PANTHERiPTHR12353 PTHR12353, 1 hit
PTHR12353:SF19 PTHR12353:SF19, 1 hit
PfamiView protein in Pfam
PF03359 GKAP, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiDLGP4_HUMAN
AccessioniPrimary (citable) accession number: Q9Y2H0
Secondary accession number(s): E1P5T5
, Q5QPG4, Q5T2Y4, Q5T2Y5, Q9H137, Q9H138, Q9H1L7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 26, 2001
Last sequence update: July 22, 2008
Last modified: November 7, 2018
This is version 153 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Human chromosome 20
    Human chromosome 20: entries, gene names and cross-references to MIM
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Main funding by: National Institutes of Health

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