Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Protein strawberry notch homolog 2

Gene

SBNO2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Acts as a transcriptional coregulator, that can have both coactivator and corepressor functions. Inhibits the DCSTAMP-repressive activity of TAL1, hence enhancing the access of the transcription factor MITF to the DC-STAMP promoter in osteoclast. Plays a role in bone homeostasis; required as a positive regulator in TNFSF11//RANKL-mediated osteoclast fusion via a DCSTAMP-dependent pathway. May also be required in the regulation of osteoblast differentiation (By similarity). Involved in the transcriptional corepression of NF-kappaB in macrophages (PubMed:18025162). Plays a role as a regulator in the proinflammatory cascade (PubMed:18025162).By similarity1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionActivator, Repressor
Biological processDifferentiation, Osteogenesis, Transcription, Transcription regulation

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Protein strawberry notch homolog 2
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:SBNO2
Synonyms:KIAA0963
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 19

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000064932.15

Human Gene Nomenclature Database

More...
HGNCi
HGNC:29158 SBNO2

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
615729 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q9Y2G9

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
22904

Open Targets

More...
OpenTargetsi
ENSG00000064932

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA162402390

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
SBNO2

Domain mapping of disease mutations (DMDM)

More...
DMDMi
166233537

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003145601 – 1366Protein strawberry notch homolog 2Add BLAST1366

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q9Y2G9

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q9Y2G9

PeptideAtlas

More...
PeptideAtlasi
Q9Y2G9

PRoteomics IDEntifications database

More...
PRIDEi
Q9Y2G9

ProteomicsDB human proteome resource

More...
ProteomicsDBi
85775
85776 [Q9Y2G9-3]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q9Y2G9

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q9Y2G9

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Detected in macrophages. IL10 regulates expression in a STAT3-dependent way.1 Publication

<p>This subsection of the ‘Expression’ section reports the experimentally proven effects of inducers and repressors (usually chemical compounds or environmental factors) on the level of protein (or mRNA) expression (up-regulation, down-regulation, constitutive expression).<p><a href='/help/induction' target='_top'>More...</a></p>Inductioni

Up-regulated by interleukin IL6 and soluble interleukin receptor IL6R in astrocytes (PubMed:25903009).1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000064932 Expressed in 178 organ(s), highest expression level in adenohypophysis

CleanEx database of gene expression profiles

More...
CleanExi
HS_SBNO2

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q9Y2G9 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q9Y2G9 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA041867

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with TAL1; this interaction inhibits TAL1 occupancy of the DCSTAMP promoter, leading to the activation of the DCSTAMP promoter by the transcription factor MITF.By similarity

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
116568, 2 interactors

Protein interaction database and analysis system

More...
IntActi
Q9Y2G9, 2 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000354733

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
Q9Y2G9

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q9Y2G9

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi183 – 195Poly-GluAdd BLAST13
Compositional biasi1234 – 1294Pro-richAdd BLAST61

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the SBNO family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1513 Eukaryota
ENOG410XQ7Q LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000159946

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000043949

The HOVERGEN Database of Homologous Vertebrate Genes

More...
HOVERGENi
HBG108461

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q9Y2G9

Identification of Orthologs from Complete Genome Data

More...
OMAi
SKIGKHH

Database of Orthologous Groups

More...
OrthoDBi
EOG091G00L4

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q9Y2G9

TreeFam database of animal gene trees

More...
TreeFami
TF313526

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR027417 P-loop_NTPase
IPR030410 SBNO2
IPR026937 SBNO_Helicase_C_dom
IPR026741 SNO
IPR039187 SNO_AAA

The PANTHER Classification System

More...
PANTHERi
PTHR12706 PTHR12706, 1 hit
PTHR12706:SF5 PTHR12706:SF5, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF13872 AAA_34, 1 hit
PF13871 Helicase_C_4, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF52540 SSF52540, 2 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 3 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q9Y2G9-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MLAVGPAMDR DYPQHEPPPA GSLLYSPPPL QSAMLHCPYW NTFSLPPYPA
60 70 80 90 100
FSSDSRPFMS SASFLGSQPC PDTSYAPVAT ASSLPPKTCD FAQDSSYFED
110 120 130 140 150
FSNISIFSSS VDSLSDIVDT PDFLPADSLN QVSTIWDDNP APSTHDKLFQ
160 170 180 190 200
LSRPFAGFED FLPSHSTPLL VSYQEQSVQS QPEEEDEAEE EEAEELGHTE
210 220 230 240 250
TYADYVPSKS KIGKQHPDRV VETSTLSSVP PPDITYTLAL PSDSGALSAL
260 270 280 290 300
QLEAITYACQ QHEVLLPSGQ RAGFLIGDGA GVGKGRTVAG VILENHLRGR
310 320 330 340 350
KKALWFSVSN DLKYDAERDL RDIEATGIAV HALSKIKYGD TTTSEGVLFA
360 370 380 390 400
TYSALIGESQ AGGQHRTRLR QILDWCGEAF EGVIVFDECH KAKNAGSTKM
410 420 430 440 450
GKAVLDLQNK LPLARVVYAS ATGASEPRNM IYMSRLGIWG EGTPFRNFEE
460 470 480 490 500
FLHAIEKRGV GAMEIVAMDM KVSGMYIARQ LSFSGVTFRI EEIPLAPAFE
510 520 530 540 550
CVYNRAALLW AEALNVFQQA ADWIGLESRK SLWGQFWSAH QRFFKYLCIA
560 570 580 590 600
AKVRRLVELA REELARDKCV VIGLQSTGEA RTREVLGEND GHLNCFVSAA
610 620 630 640 650
EGVFLSLIQK HFPSTKRKRD RGAGSKRKRR PRGRGAKAPR LACETAGVIR
660 670 680 690 700
ISDDSSTESD PGLDSDFNSS PESLVDDDVV IVDAVGLPSD DRGPLCLLQR
710 720 730 740 750
DPHGPGVLER VERLKQDLLD KVRRLGRELP VNTLDELIDQ LGGPQRVAEM
760 770 780 790 800
TGRKGRVVSR PDGTVAFESR AEQGLSIDHV NLREKQRFMS GEKLVAIISE
810 820 830 840 850
ASSSGVSLQA DRRVQNQRRR VHMTLELPWS ADRAIQQFGR THRSNQVSAP
860 870 880 890 900
EYVFLISELA GERRFASIVA KRLESLGALT HGDRRATESR DLSKYNFENK
910 920 930 940 950
YGTRALHCVL TTILSQTENK VPVPQGYPGG VPTFFRDMKQ GLLSVGIGGR
960 970 980 990 1000
ESRNGCLDVE KDCSITKFLN RILGLEVHKQ NALFQYFSDT FDHLIEMDKR
1010 1020 1030 1040 1050
EGKYDMGILD LAPGIEEIYE ESQQVFLAPG HPQDGQVVFY KISVDRGLKW
1060 1070 1080 1090 1100
EDAFAKSLAL TGPYDGFYLS YKVRGNKPSC LLAEQNRGQF FTVYKPNIGR
1110 1120 1130 1140 1150
QSQLEALDSL RRKFHRVTAE EAKEPWESGY ALSLTHCSHS AWNRHCRLAQ
1160 1170 1180 1190 1200
EGKDCLQGLR LRHHYMLCGA LLRVWGRIAA VMADVSSSSY LQIVRLKTKD
1210 1220 1230 1240 1250
RKKQVGIKIP EGCVRRVLQE LRLMDADVKR RQAPALGCPA PPAPRPLALP
1260 1270 1280 1290 1300
CGPGEVLDLT YSPPAEAFPP PPHFSFPAPL SLDAGPGVVP LGTPDAQADP
1310 1320 1330 1340 1350
AALAHQGCDI NFKEVLEDML RSLHAGPPSE GALGEGAGAG GAAGGGPERQ
1360
SVIQFSPPFP GAQAPL
Length:1,366
Mass (Da):150,275
Last modified:January 15, 2008 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i6AE084F984DDEC2E
GO
Isoform 2 (identifier: Q9Y2G9-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-93: MLAVGPAMDR...LPPKTCDFAQ → MREPLPGSAS...LWLQFEALNK

Show »
Length:1,309
Mass (Da):144,166
Checksum:iB2614E372C074B98
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
K7ES28K7ES28_HUMAN
Protein strawberry notch homolog 2
SBNO2
1,356Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
K7ERL2K7ERL2_HUMAN
Protein strawberry notch homolog 2
SBNO2
111Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
K7ENA9K7ENA9_HUMAN
Protein strawberry notch homolog 2
SBNO2
128Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAC28919 differs from that shown. Reason: Erroneous gene model prediction.Curated
The sequence BAA76807 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated
The sequence BAB84928 differs from that shown. Reason: Frameshift at position 1236.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti545K → R in BAF85096 (PubMed:14702039).Curated1
Sequence conflicti670S → F in BAG54153 (PubMed:14702039).Curated1
Sequence conflicti694P → S in BAA76807 (PubMed:10231032).Curated1
Sequence conflicti694P → S in BAB84928 (Ref. 4) Curated1
Sequence conflicti724R → Q in BAB84928 (Ref. 4) Curated1
Sequence conflicti1343A → G in BAB84928 (Ref. 4) Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting. The information stored in this subsection is used to automatically construct alternative protein sequence(s) for display.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0412161 – 93MLAVG…CDFAQ → MREPLPGSASWGTPGPPSAG TMSQLQLWLQFEALNK in isoform 2. CuratedAdd BLAST93

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AB023180 mRNA Translation: BAA76807.2 Different initiation.
AK125139 mRNA Translation: BAG54153.1
AK292407 mRNA Translation: BAF85096.1
AC005390 Genomic DNA Translation: AAC28919.1 Sequence problems.
AK074102 mRNA Translation: BAB84928.1 Frameshift.
BC106021 mRNA Translation: AAI06022.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS45894.1 [Q9Y2G9-1]
CCDS45895.1 [Q9Y2G9-3]

Protein sequence database of the Protein Information Resource

More...
PIRi
T02748

NCBI Reference Sequences

More...
RefSeqi
NP_001093592.1, NM_001100122.1 [Q9Y2G9-3]
NP_055778.2, NM_014963.2 [Q9Y2G9-1]

UniGene gene-oriented nucleotide sequence clusters

More...
UniGenei
Hs.408708

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000361757; ENSP00000354733; ENSG00000064932 [Q9Y2G9-1]
ENST00000438103; ENSP00000400762; ENSG00000064932 [Q9Y2G9-3]
ENST00000612198; ENSP00000477651; ENSG00000278788 [Q9Y2G9-1]
ENST00000622719; ENSP00000482802; ENSG00000278788 [Q9Y2G9-3]
ENST00000631948; ENSP00000488808; ENSG00000278788 [Q9Y2G9-1]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
22904

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:22904

UCSC genome browser

More...
UCSCi
uc002lrj.5 human [Q9Y2G9-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB023180 mRNA Translation: BAA76807.2 Different initiation.
AK125139 mRNA Translation: BAG54153.1
AK292407 mRNA Translation: BAF85096.1
AC005390 Genomic DNA Translation: AAC28919.1 Sequence problems.
AK074102 mRNA Translation: BAB84928.1 Frameshift.
BC106021 mRNA Translation: AAI06022.1
CCDSiCCDS45894.1 [Q9Y2G9-1]
CCDS45895.1 [Q9Y2G9-3]
PIRiT02748
RefSeqiNP_001093592.1, NM_001100122.1 [Q9Y2G9-3]
NP_055778.2, NM_014963.2 [Q9Y2G9-1]
UniGeneiHs.408708

3D structure databases

ProteinModelPortaliQ9Y2G9
SMRiQ9Y2G9
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi116568, 2 interactors
IntActiQ9Y2G9, 2 interactors
STRINGi9606.ENSP00000354733

PTM databases

iPTMnetiQ9Y2G9
PhosphoSitePlusiQ9Y2G9

Polymorphism and mutation databases

BioMutaiSBNO2
DMDMi166233537

Proteomic databases

EPDiQ9Y2G9
PaxDbiQ9Y2G9
PeptideAtlasiQ9Y2G9
PRIDEiQ9Y2G9
ProteomicsDBi85775
85776 [Q9Y2G9-3]

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000361757; ENSP00000354733; ENSG00000064932 [Q9Y2G9-1]
ENST00000438103; ENSP00000400762; ENSG00000064932 [Q9Y2G9-3]
ENST00000612198; ENSP00000477651; ENSG00000278788 [Q9Y2G9-1]
ENST00000622719; ENSP00000482802; ENSG00000278788 [Q9Y2G9-3]
ENST00000631948; ENSP00000488808; ENSG00000278788 [Q9Y2G9-1]
GeneIDi22904
KEGGihsa:22904
UCSCiuc002lrj.5 human [Q9Y2G9-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
22904
DisGeNETi22904
EuPathDBiHostDB:ENSG00000064932.15

GeneCards: human genes, protein and diseases

More...
GeneCardsi
SBNO2

H-Invitational Database, human transcriptome db

More...
H-InvDBi
HIX0014572
HGNCiHGNC:29158 SBNO2
HPAiHPA041867
MIMi615729 gene
neXtProtiNX_Q9Y2G9
OpenTargetsiENSG00000064932
PharmGKBiPA162402390

Human Unidentified Gene-Encoded large proteins database

More...
HUGEi
Search...

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG1513 Eukaryota
ENOG410XQ7Q LUCA
GeneTreeiENSGT00940000159946
HOGENOMiHOG000043949
HOVERGENiHBG108461
InParanoidiQ9Y2G9
OMAiSKIGKHH
OrthoDBiEOG091G00L4
PhylomeDBiQ9Y2G9
TreeFamiTF313526

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
SBNO2 human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
22904

Protein Ontology

More...
PROi
PR:Q9Y2G9

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000064932 Expressed in 178 organ(s), highest expression level in adenohypophysis
CleanExiHS_SBNO2
ExpressionAtlasiQ9Y2G9 baseline and differential
GenevisibleiQ9Y2G9 HS

Family and domain databases

InterProiView protein in InterPro
IPR027417 P-loop_NTPase
IPR030410 SBNO2
IPR026937 SBNO_Helicase_C_dom
IPR026741 SNO
IPR039187 SNO_AAA
PANTHERiPTHR12706 PTHR12706, 1 hit
PTHR12706:SF5 PTHR12706:SF5, 1 hit
PfamiView protein in Pfam
PF13872 AAA_34, 1 hit
PF13871 Helicase_C_4, 1 hit
SUPFAMiSSF52540 SSF52540, 2 hits

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiSBNO2_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9Y2G9
Secondary accession number(s): A8K8P2
, B3KWJ1, O75257, Q3KQX0, Q8TEM0
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: January 15, 2008
Last modified: December 5, 2018
This is version 118 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again