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UniProtKB - Q9Y2G8 (DJC16_HUMAN)

Protein

DnaJ homolog subfamily C member 16

Gene

DNAJC16

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

GO - Biological processi

View the complete GO annotation on QuickGO ...

Names & Taxonomyi

Protein namesi
Recommended name:
DnaJ homolog subfamily C member 16
Gene namesi
Name:DNAJC16
Synonyms:KIAA0962
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

EuPathDBiHostDB:ENSG00000116138.12
HGNCiHGNC:29157 DNAJC16
neXtProtiNX_Q9Y2G8

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini26 – 535CytoplasmicSequence analysisAdd BLAST510
Transmembranei536 – 556Helical; Anchor for type IV membrane proteinSequence analysisAdd BLAST21
Topological domaini557 – 782ExtracellularSequence analysisAdd BLAST226

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000116138
PharmGKBiPA142671964

Polymorphism and mutation databases

DMDMi108936027

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 25Sequence analysisAdd BLAST25
ChainiPRO_000023668326 – 782DnaJ homolog subfamily C member 16Add BLAST757

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi631N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

EPDiQ9Y2G8
PaxDbiQ9Y2G8
PeptideAtlasiQ9Y2G8
PRIDEiQ9Y2G8
ProteomicsDBi85773
85774 [Q9Y2G8-2]

PTM databases

iPTMnetiQ9Y2G8
PhosphoSitePlusiQ9Y2G8

Expressioni

Gene expression databases

BgeeiENSG00000116138 Expressed in 225 organ(s), highest expression level in oviduct epithelium
CleanExiHS_DNAJC16
ExpressionAtlasiQ9Y2G8 baseline and differential
GenevisibleiQ9Y2G8 HS

Organism-specific databases

HPAiHPA043643

Interactioni

Protein-protein interaction databases

BioGridi116926, 23 interactors
IntActiQ9Y2G8, 19 interactors
MINTiQ9Y2G8
STRINGi9606.ENSP00000365007

Structurei

3D structure databases

ProteinModelPortaliQ9Y2G8
SMRiQ9Y2G8
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini29 – 93JPROSITE-ProRule annotationAdd BLAST65
Domaini119 – 247ThioredoxinPROSITE-ProRule annotationAdd BLAST129

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi102 – 107Poly-Gln6
Compositional biasi718 – 721Poly-Glu4

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0715 Eukaryota
COG0484 LUCA
GeneTreeiENSGT00930000150920
HOGENOMiHOG000231877
HOVERGENiHBG055742
InParanoidiQ9Y2G8
KOiK09536
OMAiKQVIDDF
OrthoDBiEOG091G06I0
PhylomeDBiQ9Y2G8
TreeFamiTF312804

Family and domain databases

CDDicd06257 DnaJ, 1 hit
Gene3Di1.10.287.110, 1 hit
InterProiView protein in InterPro
IPR001623 DnaJ_domain
IPR018253 DnaJ_domain_CS
IPR036869 J_dom_sf
IPR036249 Thioredoxin-like_sf
IPR013766 Thioredoxin_domain
PfamiView protein in Pfam
PF00226 DnaJ, 1 hit
PF00085 Thioredoxin, 1 hit
PRINTSiPR00625 JDOMAIN
SMARTiView protein in SMART
SM00271 DnaJ, 1 hit
SUPFAMiSSF46565 SSF46565, 1 hit
SSF52833 SSF52833, 1 hit
PROSITEiView protein in PROSITE
PS00636 DNAJ_1, 1 hit
PS50076 DNAJ_2, 1 hit
PS51352 THIOREDOXIN_2, 1 hit

Sequences (2+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 3 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q9Y2G8-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MEVRKLSISW QFLIVLVLIL QILSALDFDP YRVLGVSRTA SQADIKKAYK 
        60         70         80         90        100
KLAREWHPDK NKDPGAEDKF IQISKAYEIL SNEEKRSNYD QYGDAGENQG 
       110        120        130        140        150
YQKQQQQREY RFRHFHENFY FDESFFHFPF NSERRDSIDE KYLLHFSHYV 
       160        170        180        190        200
NEVVPDSFKK PYLIKITSDW CFSCIHIEPV WKEVIQELEE LGVGIGVVHA 
       210        220        230        240        250
GYERRLAHHL GAHSTPSILG IINGKISFFH NAVVRENLRQ FVESLLPGNL 
       260        270        280        290        300
VEKVTNKNYV RFLSGWQQEN KPHVLLFDQT PIVPLLYKLT AFAYKDYLSF 
       310        320        330        340        350
GYVYVGLRGT EEMTRRYNIN IYAPTLLVFK EHINRPADVI QARGMKKQII 
       360        370        380        390        400
DDFITRNKYL LAARLTSQKL FHELCPVKRS HRQRKYCVVL LTAETTKLSK 
       410        420        430        440        450
PFEAFLSFAL ANTQDTVRFV HVYSNRQQEF ADTLLPDSEA FQGKSAVSIL 
       460        470        480        490        500
ERRNTAGRVV YKTLEDPWIG SESDKFILLG YLDQLRKDPA LLSSEAVLPD 
       510        520        530        540        550
LTDELAPVFL LRWFYSASDY ISDCWDSIFH NNWREMMPLL SLIFSALFIL 
       560        570        580        590        600
FGTVIVQAFS DSNDERESSP PEKEEAQEKT GKTEPSFTKE NSSKIPKKGF 
       610        620        630        640        650
VEVTELTDVT YTSNLVRLRP GHMNVVLILS NSTKTSLLQK FALEVYTFTG 
       660        670        680        690        700
SSCLHFSFLS LDKHREWLEY LLEFAQDAAP IPNQYDKHFM ERDYTGYVLA 
       710        720        730        740        750
LNGHKKYFCL FKPQKTVEEE EAIGSCSDVD SSLYLGESRG KPSCGLGSRP 
       760        770        780 
IKGKLSKLSL WMERLLEGSL QRFYIPSWPE LD
Length:782
Mass (Da):90,591
Last modified:May 30, 2006 - v3
Checksum:i42D564BBC6EED981
GO
Isoform 2 (identifier: Q9Y2G8-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-312: Missing.

Show »
Length:470
Mass (Da):53,987
Checksum:i10348C2E083AB384
GO

Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q5TDH4Q5TDH4_HUMAN
DnaJ homolog subfamily C member 16
DNAJC16
655Annotation score:
Q5TDG9Q5TDG9_HUMAN
DnaJ (Hsp40) homolog, subfamily C, ...
DNAJC16 hCG_25372
595Annotation score:
H0YCM8H0YCM8_HUMAN
DnaJ homolog subfamily C member 16
DNAJC16
97Annotation score:

Sequence cautioni

The sequence BAA76806 differs from that shown. Reason: Erroneous initiation.Curated

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0185831 – 312Missing in isoform 2. 1 PublicationAdd BLAST312

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB023179 mRNA Translation: BAA76806.2 Different initiation.
CR749259 mRNA Translation: CAH18115.1
CR749567 mRNA Translation: CAH18363.1
AL512883 Genomic DNA No translation available.
AL121992 Genomic DNA No translation available.
BC031991 mRNA Translation: AAH31991.1
BC047363 mRNA Translation: AAH47363.1
CCDSiCCDS30606.1 [Q9Y2G8-1]
CCDS72710.1 [Q9Y2G8-2]
RefSeqiNP_001274740.1, NM_001287811.1 [Q9Y2G8-2]
NP_056106.1, NM_015291.3 [Q9Y2G8-1]
UniGeneiHs.655410

Genome annotation databases

EnsembliENST00000375847; ENSP00000365007; ENSG00000116138 [Q9Y2G8-1]
ENST00000616884; ENSP00000480224; ENSG00000116138 [Q9Y2G8-2]
GeneIDi23341
KEGGihsa:23341
UCSCiuc001aws.4 human [Q9Y2G8-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB023179 mRNA Translation: BAA76806.2 Different initiation.
CR749259 mRNA Translation: CAH18115.1
CR749567 mRNA Translation: CAH18363.1
AL512883 Genomic DNA No translation available.
AL121992 Genomic DNA No translation available.
BC031991 mRNA Translation: AAH31991.1
BC047363 mRNA Translation: AAH47363.1
CCDSiCCDS30606.1 [Q9Y2G8-1]
CCDS72710.1 [Q9Y2G8-2]
RefSeqiNP_001274740.1, NM_001287811.1 [Q9Y2G8-2]
NP_056106.1, NM_015291.3 [Q9Y2G8-1]
UniGeneiHs.655410

3D structure databases

ProteinModelPortaliQ9Y2G8
SMRiQ9Y2G8
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi116926, 23 interactors
IntActiQ9Y2G8, 19 interactors
MINTiQ9Y2G8
STRINGi9606.ENSP00000365007

PTM databases

iPTMnetiQ9Y2G8
PhosphoSitePlusiQ9Y2G8

Polymorphism and mutation databases

DMDMi108936027

Proteomic databases

EPDiQ9Y2G8
PaxDbiQ9Y2G8
PeptideAtlasiQ9Y2G8
PRIDEiQ9Y2G8
ProteomicsDBi85773
85774 [Q9Y2G8-2]

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000375847; ENSP00000365007; ENSG00000116138 [Q9Y2G8-1]
ENST00000616884; ENSP00000480224; ENSG00000116138 [Q9Y2G8-2]
GeneIDi23341
KEGGihsa:23341
UCSCiuc001aws.4 human [Q9Y2G8-1]

Organism-specific databases

CTDi23341
EuPathDBiHostDB:ENSG00000116138.12
GeneCardsiDNAJC16
HGNCiHGNC:29157 DNAJC16
HPAiHPA043643
neXtProtiNX_Q9Y2G8
OpenTargetsiENSG00000116138
PharmGKBiPA142671964
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0715 Eukaryota
COG0484 LUCA
GeneTreeiENSGT00930000150920
HOGENOMiHOG000231877
HOVERGENiHBG055742
InParanoidiQ9Y2G8
KOiK09536
OMAiKQVIDDF
OrthoDBiEOG091G06I0
PhylomeDBiQ9Y2G8
TreeFamiTF312804

Miscellaneous databases

ChiTaRSiDNAJC16 human
GenomeRNAii23341
PROiPR:Q9Y2G8

Gene expression databases

BgeeiENSG00000116138 Expressed in 225 organ(s), highest expression level in oviduct epithelium
CleanExiHS_DNAJC16
ExpressionAtlasiQ9Y2G8 baseline and differential
GenevisibleiQ9Y2G8 HS

Family and domain databases

CDDicd06257 DnaJ, 1 hit
Gene3Di1.10.287.110, 1 hit
InterProiView protein in InterPro
IPR001623 DnaJ_domain
IPR018253 DnaJ_domain_CS
IPR036869 J_dom_sf
IPR036249 Thioredoxin-like_sf
IPR013766 Thioredoxin_domain
PfamiView protein in Pfam
PF00226 DnaJ, 1 hit
PF00085 Thioredoxin, 1 hit
PRINTSiPR00625 JDOMAIN
SMARTiView protein in SMART
SM00271 DnaJ, 1 hit
SUPFAMiSSF46565 SSF46565, 1 hit
SSF52833 SSF52833, 1 hit
PROSITEiView protein in PROSITE
PS00636 DNAJ_1, 1 hit
PS50076 DNAJ_2, 1 hit
PS51352 THIOREDOXIN_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiDJC16_HUMAN
AccessioniPrimary (citable) accession number: Q9Y2G8
Secondary accession number(s): Q68D57, Q86X32, Q8N5P4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 30, 2006
Last sequence update: May 30, 2006
Last modified: November 7, 2018
This is version 130 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
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