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UniProtKB - Q9Y2G8 (DJC16_HUMAN)

Entry version 150 (25 May 2022)
Sequence version 3 (30 May 2006)
Previous versions | rss
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Protein

DnaJ homolog subfamily C member 16

Gene

DNAJC16

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		Q9Y2G8

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...SignaLinki		Q9Y2G8

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
DnaJ homolog subfamily C member 16
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:DNAJC16
Synonyms:KIAA0962
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 1

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:29157, DNAJC16

neXtProt; the human protein knowledge platform

More...neXtProti		NX_Q9Y2G8

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSG00000116138

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini26 – 535CytoplasmicSequence analysisAdd BLAST510
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei536 – 556Helical; Anchor for type IV membrane proteinSequence analysisAdd BLAST21
Topological domaini557 – 782ExtracellularSequence analysisAdd BLAST226

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...DisGeNETi		23341

Open Targets

More...OpenTargetsi		ENSG00000116138

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA142671964

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		Q9Y2G8, Tdark

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		DNAJC16

Domain mapping of disease mutations (DMDM)

More...DMDMi		108936027

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 25Sequence analysisAdd BLAST25
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000023668326 – 782DnaJ homolog subfamily C member 16Add BLAST757

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi631N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		Q9Y2G8

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		Q9Y2G8

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		Q9Y2G8

MaxQB - The MaxQuant DataBase

More...MaxQBi		Q9Y2G8

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q9Y2G8

PeptideAtlas

More...PeptideAtlasi		Q9Y2G8

PRoteomics IDEntifications database

More...PRIDEi		Q9Y2G8

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		85773 [Q9Y2G8-1]
85774 [Q9Y2G8-2]

PTM databases

GlyGen: Computational and Informatics Resources for Glycoscience

More...GlyGeni		Q9Y2G8, 1 site

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q9Y2G8

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q9Y2G8

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000116138, Expressed in oviduct epithelium and 238 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		Q9Y2G8, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q9Y2G8, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000116138, Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		116926, 247 interactors

Protein interaction database and analysis system

More...IntActi		Q9Y2G8, 25 interactors

Molecular INTeraction database

More...MINTi		Q9Y2G8

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000365007

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		Q9Y2G8, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

AlphaFold Protein Structure Database

More...AlphaFoldDBi		Q9Y2G8

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q9Y2G8

Database of comparative protein structure models

More...ModBasei		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini29 – 93JPROSITE-ProRule annotationAdd BLAST65
Domaini119 – 247ThioredoxinPROSITE-ProRule annotationAdd BLAST129

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni562 – 593DisorderedSequence analysisAdd BLAST32

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi565 – 585Basic and acidic residuesSequence analysisAdd BLAST21

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG0715, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00940000155851

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_020140_0_1_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q9Y2G8

Identification of Orthologs from Complete Genome Data

More...OMAi		QREYHFR

Database of Orthologous Groups

More...OrthoDBi		1253259at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q9Y2G8

TreeFam database of animal gene trees

More...TreeFami		TF312804

Family and domain databases

Conserved Domains Database

More...CDDi		cd06257, DnaJ, 1 hit
cd02963, TRX_DnaJ, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		1.10.287.110, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR001623, DnaJ_domain
IPR018253, DnaJ_domain_CS
IPR043361, DNAJC16_TRX
IPR036869, J_dom_sf
IPR036249, Thioredoxin-like_sf
IPR013766, Thioredoxin_domain

Pfam protein domain database

More...Pfami		View protein in Pfam
PF00226, DnaJ, 1 hit
PF00085, Thioredoxin, 1 hit

Protein Motif fingerprint database; a protein domain database

More...PRINTSi		PR00625, JDOMAIN

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00271, DnaJ, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF46565, SSF46565, 1 hit
SSF52833, SSF52833, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS00636, DNAJ_1, 1 hit
PS50076, DNAJ_2, 1 hit
PS51352, THIOREDOXIN_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 3 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q9Y2G8-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <p><strong>What is the canonical sequence?</strong><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MEVRKLSISW QFLIVLVLIL QILSALDFDP YRVLGVSRTA SQADIKKAYK 
        60         70         80         90        100
KLAREWHPDK NKDPGAEDKF IQISKAYEIL SNEEKRSNYD QYGDAGENQG 
       110        120        130        140        150
YQKQQQQREY RFRHFHENFY FDESFFHFPF NSERRDSIDE KYLLHFSHYV 
       160        170        180        190        200
NEVVPDSFKK PYLIKITSDW CFSCIHIEPV WKEVIQELEE LGVGIGVVHA 
       210        220        230        240        250
GYERRLAHHL GAHSTPSILG IINGKISFFH NAVVRENLRQ FVESLLPGNL 
       260        270        280        290        300
VEKVTNKNYV RFLSGWQQEN KPHVLLFDQT PIVPLLYKLT AFAYKDYLSF 
       310        320        330        340        350
GYVYVGLRGT EEMTRRYNIN IYAPTLLVFK EHINRPADVI QARGMKKQII 
       360        370        380        390        400
DDFITRNKYL LAARLTSQKL FHELCPVKRS HRQRKYCVVL LTAETTKLSK 
       410        420        430        440        450
PFEAFLSFAL ANTQDTVRFV HVYSNRQQEF ADTLLPDSEA FQGKSAVSIL 
       460        470        480        490        500
ERRNTAGRVV YKTLEDPWIG SESDKFILLG YLDQLRKDPA LLSSEAVLPD 
       510        520        530        540        550
LTDELAPVFL LRWFYSASDY ISDCWDSIFH NNWREMMPLL SLIFSALFIL 
       560        570        580        590        600
FGTVIVQAFS DSNDERESSP PEKEEAQEKT GKTEPSFTKE NSSKIPKKGF 
       610        620        630        640        650
VEVTELTDVT YTSNLVRLRP GHMNVVLILS NSTKTSLLQK FALEVYTFTG 
       660        670        680        690        700
SSCLHFSFLS LDKHREWLEY LLEFAQDAAP IPNQYDKHFM ERDYTGYVLA 
       710        720        730        740        750
LNGHKKYFCL FKPQKTVEEE EAIGSCSDVD SSLYLGESRG KPSCGLGSRP 
       760        770        780 
IKGKLSKLSL WMERLLEGSL QRFYIPSWPE LD
Length:782
Mass (Da):90,591
Last modified:May 30, 2006 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i42D564BBC6EED981
GO
Isoform 2 (identifier: Q9Y2G8-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-312: Missing.

Show »
Length:470
Mass (Da):53,987
Checksum:i10348C2E083AB384
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q5TDH4Q5TDH4_HUMAN
DnaJ homolog subfamily C member 16
DNAJC16
655Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
Q5TDG9Q5TDG9_HUMAN
DnaJ homolog subfamily C member 16
DNAJC16 hCG_25372
595Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0YCM8H0YCM8_HUMAN
DnaJ homolog subfamily C member 16
DNAJC16
97Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence BAA76806 differs from that shown. Reason: Erroneous initiation.Curated

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0185831 – 312Missing in isoform 2. 1 PublicationAdd BLAST312

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AB023179 mRNA Translation: BAA76806.2 Different initiation.
CR749259 mRNA Translation: CAH18115.1
CR749567 mRNA Translation: CAH18363.1
AL512883 Genomic DNA No translation available.
AL121992 Genomic DNA No translation available.
BC031991 mRNA Translation: AAH31991.1
BC047363 mRNA Translation: AAH47363.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS30606.1 [Q9Y2G8-1]
CCDS72710.1 [Q9Y2G8-2]

NCBI Reference Sequences

More...RefSeqi		NP_001274740.1, NM_001287811.1 [Q9Y2G8-2]
NP_056106.1, NM_015291.3 [Q9Y2G8-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000375847.8; ENSP00000365007.3; ENSG00000116138.13
ENST00000616884.4; ENSP00000480224.1; ENSG00000116138.13 [Q9Y2G8-2]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		23341

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:23341

Matched Annotation from NCBI and EMBL-EBI (MANE) - Phase one

More...MANE-Selecti		ENST00000375847.8; ENSP00000365007.3; NM_015291.4; NP_056106.1

UCSC genome browser

More...UCSCi		uc001aws.4, human [Q9Y2G8-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB023179 mRNA Translation: BAA76806.2 Different initiation.
CR749259 mRNA Translation: CAH18115.1
CR749567 mRNA Translation: CAH18363.1
AL512883 Genomic DNA No translation available.
AL121992 Genomic DNA No translation available.
BC031991 mRNA Translation: AAH31991.1
BC047363 mRNA Translation: AAH47363.1
CCDSiCCDS30606.1 [Q9Y2G8-1]
CCDS72710.1 [Q9Y2G8-2]
RefSeqiNP_001274740.1, NM_001287811.1 [Q9Y2G8-2]
NP_056106.1, NM_015291.3 [Q9Y2G8-1]

3D structure databases

AlphaFoldDBiQ9Y2G8
SMRiQ9Y2G8
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi116926, 247 interactors
IntActiQ9Y2G8, 25 interactors
MINTiQ9Y2G8
STRINGi9606.ENSP00000365007

PTM databases

GlyGeniQ9Y2G8, 1 site
iPTMnetiQ9Y2G8
PhosphoSitePlusiQ9Y2G8

Genetic variation databases

BioMutaiDNAJC16
DMDMi108936027

Proteomic databases

EPDiQ9Y2G8
jPOSTiQ9Y2G8
MassIVEiQ9Y2G8
MaxQBiQ9Y2G8
PaxDbiQ9Y2G8
PeptideAtlasiQ9Y2G8
PRIDEiQ9Y2G8
ProteomicsDBi85773 [Q9Y2G8-1]
85774 [Q9Y2G8-2]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		46653, 34 antibodies from 15 providers

The DNASU plasmid repository

More...DNASUi		23341

Genome annotation databases

EnsembliENST00000375847.8; ENSP00000365007.3; ENSG00000116138.13
ENST00000616884.4; ENSP00000480224.1; ENSG00000116138.13 [Q9Y2G8-2]
GeneIDi23341
KEGGihsa:23341
MANE-SelectiENST00000375847.8; ENSP00000365007.3; NM_015291.4; NP_056106.1
UCSCiuc001aws.4, human [Q9Y2G8-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		23341
DisGeNETi23341

GeneCards: human genes, protein and diseases

More...GeneCardsi		DNAJC16
HGNCiHGNC:29157, DNAJC16
HPAiENSG00000116138, Low tissue specificity
neXtProtiNX_Q9Y2G8
OpenTargetsiENSG00000116138
PharmGKBiPA142671964
VEuPathDBiHostDB:ENSG00000116138

Human Unidentified Gene-Encoded large proteins database

More...HUGEi		Search...

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG0715, Eukaryota
GeneTreeiENSGT00940000155851
HOGENOMiCLU_020140_0_1_1
InParanoidiQ9Y2G8
OMAiQREYHFR
OrthoDBi1253259at2759
PhylomeDBiQ9Y2G8
TreeFamiTF312804

Enzyme and pathway databases

PathwayCommonsiQ9Y2G8
SignaLinkiQ9Y2G8

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		23341, 18 hits in 1078 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		DNAJC16, human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		23341
PharosiQ9Y2G8, Tdark

Protein Ontology

More...PROi		PR:Q9Y2G8
RNActiQ9Y2G8, protein

Gene expression databases

BgeeiENSG00000116138, Expressed in oviduct epithelium and 238 other tissues
ExpressionAtlasiQ9Y2G8, baseline and differential
GenevisibleiQ9Y2G8, HS

Family and domain databases

CDDicd06257, DnaJ, 1 hit
cd02963, TRX_DnaJ, 1 hit
Gene3Di1.10.287.110, 1 hit
InterProiView protein in InterPro
IPR001623, DnaJ_domain
IPR018253, DnaJ_domain_CS
IPR043361, DNAJC16_TRX
IPR036869, J_dom_sf
IPR036249, Thioredoxin-like_sf
IPR013766, Thioredoxin_domain
PfamiView protein in Pfam
PF00226, DnaJ, 1 hit
PF00085, Thioredoxin, 1 hit
PRINTSiPR00625, JDOMAIN
SMARTiView protein in SMART
SM00271, DnaJ, 1 hit
SUPFAMiSSF46565, SSF46565, 1 hit
SSF52833, SSF52833, 1 hit
PROSITEiView protein in PROSITE
PS00636, DNAJ_1, 1 hit
PS50076, DNAJ_2, 1 hit
PS51352, THIOREDOXIN_2, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiDJC16_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9Y2G8
Secondary accession number(s): Q68D57, Q86X32, Q8N5P4
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 30, 2006
Last sequence update: May 30, 2006
Last modified: May 25, 2022
This is version 150 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
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