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UniProtKB - Q9Y2G7 (ZFP30_HUMAN)

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Protein

Zinc finger protein 30 homolog

Gene

ZFP30

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May be involved in transcriptional regulation.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri158 – 180C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri186 – 208C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri214 – 236C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri242 – 264C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri270 – 292C2H2-type 5; degeneratePROSITE-ProRule annotationAdd BLAST23
Zinc fingeri298 – 320C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri326 – 348C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri354 – 376C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri382 – 404C2H2-type 9PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri410 – 432C2H2-type 10PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri438 – 460C2H2-type 11PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri466 – 488C2H2-type 12PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri494 – 516C2H2-type 13PROSITE-ProRule annotationAdd BLAST23

GO - Molecular functioni

View the complete GO annotation on QuickGO ...

GO - Biological processi

View the complete GO annotation on QuickGO ...

Keywordsi

Molecular functionDNA-binding
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

Enzyme and pathway databases

ReactomeiR-HSA-212436 Generic Transcription Pathway

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein 30 homolog
Short name:
Zfp-30
Alternative name(s):
Zinc finger protein 745
Gene namesi
Name:ZFP30
Synonyms:KIAA0961, ZNF745
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

EuPathDBiHostDB:ENSG00000120784.15
HGNCiHGNC:29555 ZFP30
MIMi617317 gene
neXtProtiNX_Q9Y2G7

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi22835
OpenTargetsiENSG00000120784
PharmGKBiPA143485675

Polymorphism and mutation databases

BioMutaiZFP30
DMDMi6686181

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000472911 – 519Zinc finger protein 30 homologAdd BLAST519

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei75Asymmetric dimethylarginineBy similarity1
Cross-linki110Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki141Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources

Keywords - PTMi

Isopeptide bond, Methylation, Ubl conjugation

Proteomic databases

EPDiQ9Y2G7
MaxQBiQ9Y2G7
PaxDbiQ9Y2G7
PeptideAtlasiQ9Y2G7
PRIDEiQ9Y2G7
ProteomicsDBi85772

PTM databases

iPTMnetiQ9Y2G7
PhosphoSitePlusiQ9Y2G7

Expressioni

Gene expression databases

BgeeiENSG00000120784
CleanExiHS_ZFP30
ExpressionAtlasiQ9Y2G7 baseline and differential
GenevisibleiQ9Y2G7 HS

Organism-specific databases

HPAiHPA030606

Interactioni

Protein-protein interaction databases

IntActiQ9Y2G7, 3 interactors
STRINGi9606.ENSP00000343581

Structurei

3D structure databases

ProteinModelPortaliQ9Y2G7
SMRiQ9Y2G7
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini6 – 78KRABPROSITE-ProRule annotationAdd BLAST73

Sequence similaritiesi

Belongs to the krueppel C2H2-type zinc-finger protein family.Curated

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri158 – 180C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri186 – 208C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri214 – 236C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri242 – 264C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri270 – 292C2H2-type 5; degeneratePROSITE-ProRule annotationAdd BLAST23
Zinc fingeri298 – 320C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri326 – 348C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri354 – 376C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri382 – 404C2H2-type 9PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri410 – 432C2H2-type 10PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri438 – 460C2H2-type 11PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri466 – 488C2H2-type 12PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri494 – 516C2H2-type 13PROSITE-ProRule annotationAdd BLAST23

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721 Eukaryota
COG5048 LUCA
GeneTreeiENSGT00840000129704
HOGENOMiHOG000234617
HOVERGENiHBG018163
InParanoidiQ9Y2G7
KOiK09228
OMAiYQRIHNR
OrthoDBiEOG091G02KC
PhylomeDBiQ9Y2G7
TreeFamiTF341817

Family and domain databases

CDDicd07765 KRAB_A-box, 1 hit
InterProiView protein in InterPro
IPR001909 KRAB
IPR036051 KRAB_dom_sf
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type
PfamiView protein in Pfam
PF01352 KRAB, 1 hit
SMARTiView protein in SMART
SM00349 KRAB, 1 hit
SM00355 ZnF_C2H2, 13 hits
SUPFAMiSSF109640 SSF109640, 1 hit
SSF57667 SSF57667, 7 hits
PROSITEiView protein in PROSITE
PS50805 KRAB, 1 hit
PS00028 ZINC_FINGER_C2H2_1, 12 hits
PS50157 ZINC_FINGER_C2H2_2, 13 hits

Sequencei

Sequence statusi: Complete.

Q9Y2G7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MARDLVMFRD VAVDFSQEEW ECLNSYQRNL YRDVILENYS NLVSLAGCSI 
        60         70         80         90        100
SKPDVITLLE QGKEPWMVVR DEKRRWTLDL ESRYDTKKLF QGKDIYEMNL 
       110        120        130        140        150
SQWKVMERIK SCGLEEQESP HEVCFRQVTK TTSEKMPTYR KLTSLPLYQK 
       160        170        180        190        200
SHNREKPYEC GECGKAFRVR QQLTFHQRIH TGEKPYECKE CGKAFRQCAH 
       210        220        230        240        250
LSRHQRIHTS DKLYECKKCG KIFTCGSDLR VHQRIHIGEK PYECKECGKA 
       260        270        280        290        300
FRVRGQLNLH QRIHTGEKPY ECKECGKAFR QYAHLTRHQR LNIAEKCYEC 
       310        320        330        340        350
KECGQAFLCS TGLRLHHKLH TGEKPYECKE CGKAFRVRQQ LTLHQRIHTG 
       360        370        380        390        400
EKPYDCKECG KTFSRGYHLT LHQRIHTGEK PYECKECQKF FRRYSELISH 
       410        420        430        440        450
QGIHIGEKPY ECKECGKAFR LFSQLTQHQS IHFGEKPFKC KECEKTFRLL 
       460        470        480        490        500
SQLTQHQSIH TGEKPYDCKE CGKAFRLHSS LIQHQRIHSG EKPYKCKECK 
       510 
KAFRQHSHLT YHQRIHNVT
Length:519
Mass (Da):61,558
Last modified:November 1, 1999 - v1
Checksum:iA0903F75E3B1C320
GO

Sequence cautioni

The sequence BAA76805 differs from that shown. Reason: Erroneous initiation.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB023178 mRNA Translation: BAA76805.2 Different initiation.
BC041087 mRNA Translation: AAH41087.1
CCDSiCCDS33005.1
RefSeqiNP_001307595.1, NM_001320666.1
NP_001307596.1, NM_001320667.1
NP_001307597.1, NM_001320668.1
NP_001307598.1, NM_001320669.1
NP_055713.1, NM_014898.2
UniGeneiHs.668737
Hs.716719
Hs.722657

Genome annotation databases

EnsembliENST00000351218; ENSP00000343581; ENSG00000120784
ENST00000514101; ENSP00000422930; ENSG00000120784
GeneIDi22835
KEGGihsa:22835
UCSCiuc002ogx.2 human

Similar proteinsi

Entry informationi

Entry nameiZFP30_HUMAN
AccessioniPrimary (citable) accession number: Q9Y2G7
Secondary accession number(s): Q58EY8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: November 1, 1999
Last modified: June 20, 2018
This is version 156 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

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