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Entry version 186 (02 Jun 2021)
Sequence version 2 (02 Jun 2021)
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Protein

Caspase recruitment domain-containing protein 8

Gene

CARD8

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Inflammasome sensor, which mediates inflammasome activation in response to various pathogen-associated signals, leading to subsequent pyroptosis of CD4+ T-cells and macrophages (PubMed:11821383, PubMed:11408476, PubMed:15030775, PubMed:32840892, PubMed:32051255, PubMed:33542150).

Inflammasomes are supramolecular complexes that assemble in the cytosol in response to pathogens and other damage-associated signals and play critical roles in innate immunity and inflammation (PubMed:11821383, PubMed:11408476, PubMed:15030775).

Acts as a recognition receptor (PRR): recognizes specific pathogens and other damage-associated signals, such as HIV-1 protease activity or Val-boroPro inhibitor, and mediates CARD8 inflammasome activation (PubMed:32840892, PubMed:33542150).

In response to pathogen-associated signals, the N-terminal part of CARD8 is degraded by the proteasome, releasing the cleaved C-terminal part of the protein (Caspase recruitment domain-containing protein 8, C-terminus), which polymerizes to initiate the formation of the inflammasome complex: the CARD8 inflammasome directly recruits pro-caspase-1 (proCASP1) independently of PYCARD/ASC and promotes caspase-1 (CASP1) activation, which subsequently cleaves and activates inflammatory cytokines IL1B and IL18 and gasdermin-D (GSDMD), leading to pyroptosis (PubMed:33053349, PubMed:32840892, PubMed:32051255, PubMed:33542150).

Ability to sense HIV-1 protease activity leads to the clearance of latent HIV-1 in patient CD4+ T-cells after viral reactivation; in contrast, HIV-1 can evade CARD8-sensing when its protease remains inactive in infected cells prior to viral budding (PubMed:33542150).

Also acts as a negative regulator of the NLRP3 inflammasome (PubMed:24517500).

May also act as an inhibitor of NF-kappa-B activation (PubMed:11551959, PubMed:12067710).

10 Publications

Constitutes the precusor of the CARD8 inflammasome, which mediates autoproteolytic processing within the FIIND domain to generate the N-terminal and C-terminal parts, which are associated non-covalently in absence of pathogens and other damage-associated signals.

1 Publication

Regulatory part that prevents formation of the CARD8 inflammasome: in absence of pathogens and other damage-associated signals, interacts with the C-terminal part of CARD8 (Caspase recruitment domain-containing protein 8, C-terminus), preventing activation of the CARD8 inflammasome (PubMed:33542150).

In response to pathogen-associated signals, this part is ubiquitinated by the N-end rule pathway and degraded by the proteasome, releasing the cleaved C-terminal part of the protein, which polymerizes and forms the CARD8 inflammasome (Probable) (PubMed:32558991).

1 Publication1 Publication1 Publication

Constitutes the active part of the CARD8 inflammasome (PubMed:32840892).

In absence of pathogens and other damage-associated signals, interacts with the N-terminal part of CARD8 (Caspase recruitment domain-containing protein 8, N-terminus), preventing activation of the CARD8 inflammasome (PubMed:33542150).

In response to pathogen-associated signals, the N-terminal part of CARD8 is degraded by the proteasome, releasing this form, which polymerizes to form the CARD8 inflammasome complex: the CARD8 inflammasome complex then directly recruits pro-caspase-1 (proCASP1) and promotes caspase-1 (CASP1) activation, leading to gasdermin-D (GSDMD) cleavage and subsequent pyroptosis (PubMed:32840892, PubMed:33542150).

2 Publications

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes regulatory mechanisms for enzymes, transporters or microbial transcription factors, and reports the components which regulate (by activation or inhibition) the reaction.<p><a href='/help/activity_regulation' target='_top'>More...</a></p>Activity regulationi

CARD8 inflammasome is activated by HIV-1 protease activity: HIV-1 protease cleaves CARD8, promoting ubiquitination and degradation of the N-terminal part, releasing the cleaved C-terminal part of the protein (Caspase recruitment domain-containing protein 8, C-terminus), which polymerizes and forms the CARD8 inflammasome (PubMed:33542150). CARD8 inflammasome is inhibited by DPP8 and DPP9 via an unknown mechanism (PubMed:29967349, PubMed:31525884, PubMed:32796818). CARD8 inflammasome is activated by Val-boroPro (Talabostat, PT-100), an inhibitor of dipeptidyl peptidases DPP8 and DPP9 (PubMed:29967349, PubMed:31525884, PubMed:32796818, PubMed:33053349, PubMed:32840892). Val-boroPro relieves inhibition of DPP8 and/or DPP9 by inducing the proteasome-mediated destruction of the N-terminal part of CARD8, releasing its C-terminal part from autoinhibition (PubMed:29967349, PubMed:31525884, PubMed:32796818).6 Publications

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection describes interesting single amino acid sites on the sequence that are not defined in any other subsection. This subsection can be displayed in different sections ('Function', 'PTM / Processing', 'Pathology and Biotech') according to its content.<p><a href='/help/site' target='_top'>More...</a></p>Sitei59 – 60(Microbial infection) Cleavage; by HIV-1 protease1 Publication2

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionHydrolase, Protease
Biological processHost-virus interaction, Immunity, Inflammatory response, Innate immunity, Necrosis

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...
PathwayCommonsi
Q9Y2G2

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-111458, Formation of apoptosome
R-HSA-9627069, Regulation of the apoptosome activity

SIGNOR Signaling Network Open Resource

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SIGNORi
Q9Y2G2

Protein family/group databases

MEROPS protease database

More...
MEROPSi
S79.001

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Caspase recruitment domain-containing protein 8Curated (EC:3.4.-.-1 Publication)
Alternative name(s):
CARD-inhibitor of NF-kappa-B-activating ligand1 Publication
Short name:
CARDINAL1 Publication
Tumor up-regulated CARD-containing antagonist of CASP91 Publication
Short name:
TUCAN1 Publication
Cleaved into the following 2 chains:
Caspase recruitment domain-containing protein 8, C-terminusCurated
Short name:
CARD8-CT1 Publication
Caspase recruitment domain-containing protein 8, N-terminusCurated
Short name:
CARD8-NT1 Publication
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:CARD81 PublicationImported
Synonyms:DACAR1 Publication, KIAA09551 Publication, NDPP11 Publication
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 19

Organism-specific databases

Human Gene Nomenclature Database

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HGNCi
HGNC:17057, CARD8

Online Mendelian Inheritance in Man (OMIM)

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MIMi
609051, gene

neXtProt; the human protein knowledge platform

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neXtProti
NX_Q9Y2G2

Eukaryotic Pathogen, Vector and Host Database Resources

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VEuPathDBi
HostDB:ENSG00000105483.16

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Cytoplasm, Inflammasome, Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the 'Pathology and Biotech' section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Inflammatory bowel disease 30 (IBD30)5 Publications
The disease may be caused by variants affecting the gene represented in this entry. A number of groups have studied the possible association between variant rs2043211 and inflammatory bowel disease (PubMed:17030188, PubMed:19319132, PubMed:23506543, PubMed:26462578). According to some studies involving a limited number of patients, this variant is associated with inflammatory bowel disease (PubMed:17030188, PubMed:19319132, PubMed:23506543). Such association is however not confirmed in studies involving a large number of patients (PubMed:26462578). Discrepancies between studies may be caused by the variable consequences of this polymorphism in the different isoforms (PubMed:29408806). Whereas rs2043211 introduces a stop codon after 'Cys-10' (Cys10Ter) in isoform 1, and therefore the likely formation of a downstream transcriptional start site for this isoform, it causes Ile-102 variation in isoform 5, due to the upstream start site (PubMed:29408806). Moreover, most patients bearing this polymorphism continue to express the slightly smaller but fully functional isoform 7, as a result of transcription downstream of the rs2043211 polymorphism (PubMed:29408806).5 Publications
Disease descriptionA chronic, relapsing inflammation of the gastrointestinal tract with a complex etiology and a multifactorial inheritance pattern. It is subdivided into Crohn disease and ulcerative colitis phenotypes. Crohn disease may affect any part of the gastrointestinal tract from the mouth to the anus, but most frequently it involves the terminal ileum and colon. Bowel inflammation is transmural and discontinuous; it may contain granulomas or be associated with intestinal or perianal fistulas. In contrast, in ulcerative colitis, the inflammation is continuous and limited to rectal and colonic mucosal layers; fistulas and granulomas are not observed. Both diseases include extraintestinal inflammation of the skin, eyes, or joints.
Related information in OMIM
Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_08456044V → I in IBD30; unknown pathological significance. 1 Publication1
Natural variantiVAR_084561102F → I in IBD30. 4 PublicationsCorresponds to variant dbSNP:rs2043211Ensembl.1
Isoform 1 (identifier: Q9Y2G2-1)
Natural variantiVAR_08456210 – 431Missing in IBD30. 4 PublicationsCorresponds to variant dbSNP:rs2043211Add BLAST422

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology%5Fand%5Fbiotech%5Fsection">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi51L → A: Does not affect cleavage by HIV-1 protease. 1 Publication1
Mutagenesisi52Q → A: Does not affect cleavage by HIV-1 protease. 1 Publication1
Mutagenesisi53Y → A: Does not affect cleavage by HIV-1 protease. 1 Publication1
Mutagenesisi54T → A: Does not affect cleavage by HIV-1 protease. 1 Publication1
Mutagenesisi55K → A: Does not affect cleavage by HIV-1 protease. 1 Publication1
Mutagenesisi56T → A: Does not affect cleavage by HIV-1 protease. 1 Publication1
Mutagenesisi57G → A: Does not affect cleavage by HIV-1 protease. 1 Publication1
Mutagenesisi58I → A: Does not affect cleavage by HIV-1 protease. 1 Publication1
Mutagenesisi59F → A: Abolished cleavage by HIV-1 protease, leading to prevent formation of the CARD8 inflammasome and subsequent pyroptosis. 1 Publication1
Mutagenesisi60F → A: Abolished cleavage by HIV-1 protease, leading to prevent formation of the CARD8 inflammasome and subsequent pyroptosis. 1 Publication1
Mutagenesisi157K → R: Does not affect sensitivity to Val-boroPro. 1 Publication1
Mutagenesisi240E → A: No effect on autocatalytic cleavage. 1 Publication1
Mutagenesisi242E → A: No effect on autocatalytic cleavage. 1 Publication1
Mutagenesisi252H → A: Severe loss of autocatalytic cleavage. 1 Publication1
Mutagenesisi270H → A: Severe loss of autocatalytic cleavage. 1 Publication1
Mutagenesisi279E → A: Partial loss of autocatalytic cleavage. 1 Publication1
Mutagenesisi280H → A: No effect on autocatalytic cleavage. 1 Publication1
Mutagenesisi295S → A: Partial loss of autocatalytic cleavage. 1 Publication1
Mutagenesisi295S → Q: No effect on autocatalytic cleavage. 1 Publication1
Mutagenesisi296F → H: Severe loss of autocatalytic cleavage. 1 Publication1
Mutagenesisi297S → A: Complete loss of autocatalytic cleavage. Abolished ability to form the CARD8 inflammasome and trigger pyroptosis. Abolished sensitivity to Val-boroPro. Does not affect interaction with DPP9. 5 Publications1
Mutagenesisi333H → A: No effect on autocatalytic cleavage. 1 Publication1
Mutagenesisi459R → E: Abolished formation of inflammasome filaments. Abolished ability to induce pyroptosis. 1 Publication1
Mutagenesisi464R → E: Abolished formation of inflammasome filaments. Abolished ability to induce pyroptosis. 1 Publication1
Mutagenesisi472L → R: Inhibits homodimer formation. 1 Publication1
Mutagenesisi485E → R: Abolished formation of inflammasome filaments. Abolished ability to induce pyroptosis. 1 Publication1
Mutagenesisi490E → R: Abolished formation of inflammasome filaments. 1 Publication1
Mutagenesisi495R → E: Abolished formation of inflammasome filaments. Abolished ability to induce pyroptosis. 1 Publication1
Mutagenesisi511D → K: Abolished formation of inflammasome filaments. Reduced ability to induce pyroptosis. 1 Publication1
Mutagenesisi527Y → A: Abolished formation of inflammasome filaments. Abolished ability to induce pyroptosis. 1 Publication1
Isoform 1 (identifier: Q9Y2G2-1)
Mutagenesisi152Q → QA: Increased autocalalytic cleavage. 1 Publication1

Keywords - Diseasei

Disease variant

Organism-specific databases

DisGeNET

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DisGeNETi
22900
MIMi619079, phenotype

Open Targets

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OpenTargetsi
ENSG00000105483

The Pharmacogenetics and Pharmacogenomics Knowledge Base

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PharmGKBi
PA134916154

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q9Y2G2, Tbio

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
CARD8

Domain mapping of disease mutations (DMDM)

More...
DMDMi
14424229

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001440801 – 537Caspase recruitment domain-containing protein 8Add BLAST537
ChainiPRO_00004528471 – 296Caspase recruitment domain-containing protein 8, N-terminusAdd BLAST296
ChainiPRO_0000452848297 – 537Caspase recruitment domain-containing protein 8, C-terminusAdd BLAST241

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Undergoes autocatalytic processing within the FIIND domain to generate the N-terminal and C-terminal parts, which are associated non-covalently in absence of pathogens and other damage-associated signals.2 Publications
Ubiquitinated by the N-end rule pathway in response to pathogens and other damage-associated signals, leading to its degradation by the proteasome and subsequent release of the cleaved C-terminal part of the protein (Caspase recruitment domain-containing protein 8, C-terminus), which polymerizes and forms the CARD8 inflammasome.1 Publication1 Publication
(Microbial infection) Proteolytic cleavage by HIV-1 protease in the disordered region and within the ZU5 region of the FIIND domain promotes ubiquitination of the N-terminal part by the N-end rule pathway and degradation by the proteasome, releasing the cleaved C-terminal part of the protein (Caspase recruitment domain-containing protein 8, C-terminus), which polymerizes and forms the CARD8 inflammasome.1 Publication
Undergoes less autocatalytic processing within the FIIND domain compared to isoform 5.1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei296 – 297Cleavage; by autolysisPROSITE-ProRule annotation3 Publications2

Keywords - PTMi

Ubl conjugation

Proteomic databases

Encyclopedia of Proteome Dynamics

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EPDi
Q9Y2G2

MassIVE - Mass Spectrometry Interactive Virtual Environment

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MassIVEi
Q9Y2G2

PaxDb, a database of protein abundance averages across all three domains of life

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PaxDbi
Q9Y2G2

PeptideAtlas

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PeptideAtlasi
Q9Y2G2

PRoteomics IDEntifications database

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PRIDEi
Q9Y2G2

ProteomicsDB: a multi-organism proteome resource

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ProteomicsDBi
19923
33792
85761 [Q9Y2G2-1]
85762 [Q9Y2G2-2]
85763 [Q9Y2G2-3]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q9Y2G2

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

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PhosphoSitePlusi
Q9Y2G2

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

High expression in lung, ovary, testis and placenta (PubMed:11551959). Lower expression in heart, kidney and liver (PubMed:11551959). Also expressed in spleen, lymph node and bone marrow (PubMed:11821383).2 Publications

Gene expression databases

Bgee dataBase for Gene Expression Evolution

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Bgeei
ENSG00000105483, Expressed in spleen and 217 other tissues

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
Q9Y2G2, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
Q9Y2G2, HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
ENSG00000105483, Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with DPP8; leading to inhibit activation of the inflammasome via an unknown mechanism (PubMed:31525884).

Interacts with DPP9; leading to inhibit activation of the inflammasome via an unknown mechanism (PubMed:31525884).

Interacts with NLRP3 (PubMed:24517500).

Interacts with IKBKG/NEMO (PubMed:11551959).

Interacts with DRAL (PubMed:12067710). Binds to caspase-1 (CASP1), CARD16/pseudo-ICE and CARD18/ICEBERG (PubMed:11821383).

Interacts with NLRP2 (via NACHT domain) (PubMed:15030775).

6 Publications

Interacts with the C-terminal part of CARD8 (Caspase recruitment domain-containing protein 8, C-terminus) in absence of pathogens and other damage-associated signals.

1 Publication

Interacts with the N-terminal part of CARD8 (Caspase recruitment domain-containing protein 8, N-terminus) in absence of pathogens and other damage-associated signals (PubMed:33542150). Homomultimer; forms the CARD8 inflammasome polymeric complex, a filament composed of homopolymers of this form in response to pathogens and other damage-associated signals (PubMed:33420028, PubMed:33420033). The CARD8 inflammasome polymeric complex directly recruits pro-caspase-1 (proCASP1) independently of PYCARD/ASC (PubMed:32051255).

Interacts (via CARD domain) with CASP1 (via CARD domain); leading to CASP1 activation (PubMed:33542150, PubMed:33420033).

4 Publications

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

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BioGRIDi
116564, 47 interactors

CORUM comprehensive resource of mammalian protein complexes

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CORUMi
Q9Y2G2

Protein interaction database and analysis system

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IntActi
Q9Y2G2, 37 interactors

Molecular INTeraction database

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MINTi
Q9Y2G2

STRING: functional protein association networks

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STRINGi
9606.ENSP00000375767

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

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RNActi
Q9Y2G2, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1537
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
Q9Y2G2

Database of comparative protein structure models

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ModBasei
Search...

Protein Data Bank in Europe - Knowledge Base

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PDBe-KBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini161 – 446FIINDPROSITE-ProRule annotationAdd BLAST286
Domaini446 – 536CARDPROSITE-ProRule annotationAdd BLAST91

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni161 – 296ZU51 PublicationAdd BLAST136
Regioni297 – 446UPA1 PublicationAdd BLAST150

<p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The disordered region is required for activation of the CARD8 inflammasome.1 Publication
The C-terminal part of CARD8 oligomerizes to form the core of the CARD8 inflammasome filament: in the filament, the CARD domains form a central helical filaments that are promoted by oligomerized, but flexibly linked, UPA regions surrounding the filaments (PubMed:33420028, PubMed:33420033). The UPA region reduces the threshold needed for filament formation and signaling (PubMed:33420028, PubMed:33420033). Directly recruits and polymerizes with the CARD domain of caspase-1 (CASP1) through the favorable side of the growing filament seed (PubMed:33420033).2 Publications

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG3573, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00830000128447

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_037186_1_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q9Y2G2

Identification of Orthologs from Complete Genome Data

More...
OMAi
MEPLNFG

Database of Orthologous Groups

More...
OrthoDBi
559093at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q9Y2G2

TreeFam database of animal gene trees

More...
TreeFami
TF352798

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR001315, CARD
IPR011029, DEATH-like_dom_sf
IPR025307, FIIND_dom

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00619, CARD, 1 hit
PF13553, FIIND, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF47986, SSF47986, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50209, CARD, 1 hit
PS51830, FIIND, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (7+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 7 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 7 described isoforms and 9 potential isoforms that are computationally mapped.Show allAlign All

Isoform 5 (identifier: Q9Y2G2-5) [UniParc]FASTAAdd to basket
Also known as: T601 Publication, a

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MEKKECPEKS SSSEEELPRR DSGSSRNIDA SKLIRLQGSR KLLVDNSIRE
60 70 80 90 100
LQYTKTGIFF QAEACVTNDT VYRELPCVSE TLCDISHFFQ EDDETEAEPL
110 120 130 140 150
LFRAVPECQL SGGDIPSVSE EQESSEGQDS GDICSEENQI VSSYASKVCF
160 170 180 190 200
EIEEDYKNRQ FLGPEGNVDV ELIDKSTNRY SVWFPTAGWY LWSATGLGFL
210 220 230 240 250
VRDEVTVTIA FGSWSQHLAL DLQHHEQWLV GGPLFDVTAE PEEAVAEIHL
260 270 280 290 300
PHFISLQAGE VDVSWFLVAH FKNEGMVLEH PARVEPFYAV LESPSFSLMG
310 320 330 340 350
ILLRIASGTR LSIPITSNTL IYYHPHPEDI KFHLYLVPSD ALLTKAIDDE
360 370 380 390 400
EDRFHGVRLQ TSPPMEPLNF GSSYIVSNSA NLKVMPKELK LSYRSPGEIQ
410 420 430 440 450
HFSKFYAGQM KEPIQLEITE KRHGTLVWDT EVKPVDLQLV AASAPPPFSG
460 470 480 490 500
AAFVKENHRQ LQARMGDLKG VLDDLQDNEV LTENEKELVE QEKTRQSKNE
510 520 530
ALLSMVEKKG DLALDVLFRS ISERDPYLVS YLRQQNL
Length:537
Mass (Da):60,652
Last modified:June 2, 2021 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i55775D025C5461BE
GO
Isoform 1 (identifier: Q9Y2G2-1) [UniParc]FASTAAdd to basket
Also known as: Long, T481 Publication

The sequence of this isoform differs from the canonical sequence as follows:
     1-130: MEKKECPEKS...EQESSEGQDS → MMRQRQSHYCSVLFLSVNYLGGTFP
     258-258: Missing.

Show »
Length:431
Mass (Da):48,933
Checksum:iCB54D130807732E6
GO
Isoform 2 (identifier: Q9Y2G2-2) [UniParc]FASTAAdd to basket
Also known as: Short

The sequence of this isoform differs from the canonical sequence as follows:
     1-130: MEKKECPEKS...EQESSEGQDS → MMRQRQSHYCSVLFLSVNYLGGTFP
     258-258: Missing.
     388-392: ELKLS → WISSL
     393-537: Missing.

Show »
Length:286
Mass (Da):32,369
Checksum:iE6344DB98904F814
GO
Isoform 3 (identifier: Q9Y2G2-3) [UniParc]FASTAAdd to basket
Also known as: c

The sequence of this isoform differs from the canonical sequence as follows:
     388-392: ELKLS → WISSL
     393-537: Missing.

Show »
Length:392
Mass (Da):44,088
Checksum:i69F2C3DF325C3043
GO
Isoform 4 (identifier: Q9Y2G2-4) [UniParc]FASTAAdd to basket
Also known as: T541 Publication, b

The sequence of this isoform differs from the canonical sequence as follows:
     21-70: Missing.

Show »
Length:487
Mass (Da):55,109
Checksum:iBE398DFC6F431003
GO
Isoform 6 (identifier: Q9Y2G2-6) [UniParc]FASTAAdd to basket
Also known as: d

The sequence of this isoform differs from the canonical sequence as follows:
     71-537: Missing.

Show »
Length:70
Mass (Da):7,923
Checksum:i125AD8AC575A1FCA
GO
Isoform 7 (identifier: Q9Y2G2-7) [UniParc]FASTAAdd to basket
Also known as: T471 Publication

The sequence of this isoform differs from the canonical sequence as follows:
     1-116: MEKKECPEKS...ECQLSGGDIP → MGIPTS

Show »
Length:427
Mass (Da):48,152
Checksum:i848C0869370CB599
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 9 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E5RGG3E5RGG3_HUMAN
Caspase recruitment domain-containi...
CARD8
39Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E5RHJ3E5RHJ3_HUMAN
Caspase recruitment domain-containi...
CARD8
132Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E5RHZ3E5RHZ3_HUMAN
Caspase recruitment domain-containi...
CARD8
146Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E5RFI5E5RFI5_HUMAN
Caspase recruitment domain-containi...
CARD8
132Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0YB90H0YB90_HUMAN
Caspase recruitment domain-containi...
CARD8
70Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E5RIN1E5RIN1_HUMAN
Caspase recruitment domain-containi...
CARD8
138Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E5RGC9E5RGC9_HUMAN
Caspase recruitment domain-containi...
CARD8
82Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E5RJG3E5RJG3_HUMAN
Caspase recruitment domain-containi...
CARD8
43Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0YBW7H0YBW7_HUMAN
Caspase recruitment domain-containi...
CARD8
24Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence BAA76799 differs from that shown. Reason: Erroneous initiation. Extended N-terminus.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti84D → G in ABW96891 (PubMed:18212821).Curated1
Sequence conflicti107E → D in ABW96891 (PubMed:18212821).Curated1
Sequence conflicti165E → G in AAL02427 (PubMed:11551959).Curated1
Sequence conflicti253F → S in AAH56891 (PubMed:15489334).Curated1
Sequence conflicti325P → R in BAH12488 (PubMed:14702039).Curated1
Sequence conflicti432V → M in AAL02427 (PubMed:11551959).Curated1
Sequence conflicti523E → G in ABW96891 (PubMed:18212821).Curated1
Sequence conflicti523E → G in ABW96893 (PubMed:18212821).Curated1
Sequence conflicti528L → P in AAL02427 (PubMed:11551959).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_08456044V → I in IBD30; unknown pathological significance. 1 Publication1
Natural variantiVAR_084561102F → I in IBD30. 4 PublicationsCorresponds to variant dbSNP:rs2043211Ensembl.1
Natural variantiVAR_048606173I → V1 PublicationCorresponds to variant dbSNP:rs11881179Ensembl.1
Natural variantiVAR_061079204E → A1 PublicationCorresponds to variant dbSNP:rs59878320Ensembl.1
Isoform 1 (identifier: Q9Y2G2-1)
Natural variantiVAR_08456210 – 431Missing in IBD30. 4 PublicationsCorresponds to variant dbSNP:rs2043211Add BLAST422

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0610681 – 130MEKKE…EGQDS → MMRQRQSHYCSVLFLSVNYL GGTFP in isoform 1 and isoform 2. Add BLAST130
Alternative sequenceiVSP_0610691 – 116MEKKE…GGDIP → MGIPTS in isoform 7. Add BLAST116
Alternative sequenceiVSP_06107021 – 70Missing in isoform 4. Add BLAST50
Alternative sequenceiVSP_06107171 – 537Missing in isoform 6. Add BLAST467
Alternative sequenceiVSP_061072258Missing in isoform 1 and isoform 2. 1
Alternative sequenceiVSP_061073388 – 392ELKLS → WISSL in isoform 3 and isoform 2. 5
Alternative sequenceiVSP_061074393 – 537Missing in isoform 3 and isoform 2. Add BLAST145

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AB023172 mRNA Translation: BAA76799.2 Different initiation.
AF322184 mRNA Translation: AAG50014.1
AF331519 mRNA Translation: AAK01126.1
AY026322 mRNA Translation: AAK08982.1
AF405558 mRNA Translation: AAL02427.1
EU118120 mRNA Translation: ABW96891.1
EU118122 mRNA Translation: ABW96893.1
AF511652 mRNA Translation: AAM46959.1
AK297045 mRNA Translation: BAH12482.1
AK297069 mRNA Translation: BAH12488.1
AC008392 Genomic DNA No translation available.
AC011466 Genomic DNA No translation available.
CH471177 Genomic DNA Translation: EAW52321.1
CH471177 Genomic DNA Translation: EAW52323.1
BC056891 mRNA Translation: AAH56891.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS12712.2 [Q9Y2G2-4]
CCDS54288.1 [Q9Y2G2-3]
CCDS54289.1 [Q9Y2G2-5]

NCBI Reference Sequences

More...
RefSeqi
NP_001171829.1, NM_001184900.1 [Q9Y2G2-5]
NP_001171830.1, NM_001184901.1 [Q9Y2G2-4]
NP_001171831.1, NM_001184902.1 [Q9Y2G2-3]
NP_001171832.1, NM_001184903.1 [Q9Y2G2-3]
NP_055774.2, NM_014959.3 [Q9Y2G2-4]
XP_006723154.1, XM_006723091.3 [Q9Y2G2-5]
XP_006723155.1, XM_006723092.3 [Q9Y2G2-5]
XP_006723156.1, XM_006723093.3 [Q9Y2G2-5]
XP_006723158.1, XM_006723095.3
XP_006723159.1, XM_006723096.3 [Q9Y2G2-4]
XP_006723160.1, XM_006723097.3 [Q9Y2G2-4]
XP_006723167.1, XM_006723104.3 [Q9Y2G2-1]
XP_006723169.1, XM_006723106.3 [Q9Y2G2-3]
XP_006723172.1, XM_006723109.3 [Q9Y2G2-2]
XP_011524943.1, XM_011526641.2 [Q9Y2G2-5]
XP_011524944.1, XM_011526642.2
XP_011524945.1, XM_011526643.2 [Q9Y2G2-5]
XP_011524946.1, XM_011526644.2 [Q9Y2G2-5]
XP_011524952.1, XM_011526650.2 [Q9Y2G2-3]
XP_016881972.1, XM_017026483.1 [Q9Y2G2-4]
XP_016881979.1, XM_017026490.1
XP_016881987.1, XM_017026498.1 [Q9Y2G2-2]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000391898; ENSP00000375767; ENSG00000105483 [Q9Y2G2-5]
ENST00000447740; ENSP00000391248; ENSG00000105483 [Q9Y2G2-4]
ENST00000519940; ENSP00000428883; ENSG00000105483 [Q9Y2G2-5]
ENST00000520015; ENSP00000430747; ENSG00000105483 [Q9Y2G2-3]
ENST00000520153; ENSP00000428736; ENSG00000105483 [Q9Y2G2-4]
ENST00000520753; ENSP00000429839; ENSG00000105483 [Q9Y2G2-3]
ENST00000521613; ENSP00000427858; ENSG00000105483 [Q9Y2G2-4]
ENST00000651546; ENSP00000499211; ENSG00000105483 [Q9Y2G2-5]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
22900

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:22900

UCSC genome browser

More...
UCSCi
uc002pih.5, human [Q9Y2G2-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross%5Freferences%5Fsection">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB023172 mRNA Translation: BAA76799.2 Different initiation.
AF322184 mRNA Translation: AAG50014.1
AF331519 mRNA Translation: AAK01126.1
AY026322 mRNA Translation: AAK08982.1
AF405558 mRNA Translation: AAL02427.1
EU118120 mRNA Translation: ABW96891.1
EU118122 mRNA Translation: ABW96893.1
AF511652 mRNA Translation: AAM46959.1
AK297045 mRNA Translation: BAH12482.1
AK297069 mRNA Translation: BAH12488.1
AC008392 Genomic DNA No translation available.
AC011466 Genomic DNA No translation available.
CH471177 Genomic DNA Translation: EAW52321.1
CH471177 Genomic DNA Translation: EAW52323.1
BC056891 mRNA Translation: AAH56891.1
CCDSiCCDS12712.2 [Q9Y2G2-4]
CCDS54288.1 [Q9Y2G2-3]
CCDS54289.1 [Q9Y2G2-5]
RefSeqiNP_001171829.1, NM_001184900.1 [Q9Y2G2-5]
NP_001171830.1, NM_001184901.1 [Q9Y2G2-4]
NP_001171831.1, NM_001184902.1 [Q9Y2G2-3]
NP_001171832.1, NM_001184903.1 [Q9Y2G2-3]
NP_055774.2, NM_014959.3 [Q9Y2G2-4]
XP_006723154.1, XM_006723091.3 [Q9Y2G2-5]
XP_006723155.1, XM_006723092.3 [Q9Y2G2-5]
XP_006723156.1, XM_006723093.3 [Q9Y2G2-5]
XP_006723158.1, XM_006723095.3
XP_006723159.1, XM_006723096.3 [Q9Y2G2-4]
XP_006723160.1, XM_006723097.3 [Q9Y2G2-4]
XP_006723167.1, XM_006723104.3 [Q9Y2G2-1]
XP_006723169.1, XM_006723106.3 [Q9Y2G2-3]
XP_006723172.1, XM_006723109.3 [Q9Y2G2-2]
XP_011524943.1, XM_011526641.2 [Q9Y2G2-5]
XP_011524944.1, XM_011526642.2
XP_011524945.1, XM_011526643.2 [Q9Y2G2-5]
XP_011524946.1, XM_011526644.2 [Q9Y2G2-5]
XP_011524952.1, XM_011526650.2 [Q9Y2G2-3]
XP_016881972.1, XM_017026483.1 [Q9Y2G2-4]
XP_016881979.1, XM_017026490.1
XP_016881987.1, XM_017026498.1 [Q9Y2G2-2]

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...
PDBei

Protein Data Bank RCSB

More...
RCSB PDBi

Protein Data Bank Japan

More...
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4IKMX-ray2.46A451-537[»]
6K9Felectron microscopy3.70A/B/C/D/E/F/G/H/I/J/K/L451-537[»]
6XKJelectron microscopy3.54A/B/C/D/E/F/G/H/I/J/K/L/M/N/O/P451-537[»]
SMRiQ9Y2G2
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi116564, 47 interactors
CORUMiQ9Y2G2
IntActiQ9Y2G2, 37 interactors
MINTiQ9Y2G2
STRINGi9606.ENSP00000375767

Protein family/group databases

MEROPSiS79.001

PTM databases

iPTMnetiQ9Y2G2
PhosphoSitePlusiQ9Y2G2

Genetic variation databases

BioMutaiCARD8
DMDMi14424229

Proteomic databases

EPDiQ9Y2G2
MassIVEiQ9Y2G2
PaxDbiQ9Y2G2
PeptideAtlasiQ9Y2G2
PRIDEiQ9Y2G2
ProteomicsDBi19923
33792
85761 [Q9Y2G2-1]
85762 [Q9Y2G2-2]
85763 [Q9Y2G2-3]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...
Antibodypediai
18287, 307 antibodies

The DNASU plasmid repository

More...
DNASUi
22900

Genome annotation databases

EnsembliENST00000391898; ENSP00000375767; ENSG00000105483 [Q9Y2G2-5]
ENST00000447740; ENSP00000391248; ENSG00000105483 [Q9Y2G2-4]
ENST00000519940; ENSP00000428883; ENSG00000105483 [Q9Y2G2-5]
ENST00000520015; ENSP00000430747; ENSG00000105483 [Q9Y2G2-3]
ENST00000520153; ENSP00000428736; ENSG00000105483 [Q9Y2G2-4]
ENST00000520753; ENSP00000429839; ENSG00000105483 [Q9Y2G2-3]
ENST00000521613; ENSP00000427858; ENSG00000105483 [Q9Y2G2-4]
ENST00000651546; ENSP00000499211; ENSG00000105483 [Q9Y2G2-5]
GeneIDi22900
KEGGihsa:22900
UCSCiuc002pih.5, human [Q9Y2G2-1]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
22900
DisGeNETi22900

GeneCards: human genes, protein and diseases

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GeneCardsi
CARD8
HGNCiHGNC:17057, CARD8
HPAiENSG00000105483, Low tissue specificity
MIMi609051, gene
619079, phenotype
neXtProtiNX_Q9Y2G2
OpenTargetsiENSG00000105483
PharmGKBiPA134916154
VEuPathDBiHostDB:ENSG00000105483.16

Human Unidentified Gene-Encoded large proteins database

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HUGEi
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GenAtlas: human gene database

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GenAtlasi
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Phylogenomic databases

eggNOGiKOG3573, Eukaryota
GeneTreeiENSGT00830000128447
HOGENOMiCLU_037186_1_0_1
InParanoidiQ9Y2G2
OMAiMEPLNFG
OrthoDBi559093at2759
PhylomeDBiQ9Y2G2
TreeFamiTF352798

Enzyme and pathway databases

PathwayCommonsiQ9Y2G2
ReactomeiR-HSA-111458, Formation of apoptosome
R-HSA-9627069, Regulation of the apoptosome activity
SIGNORiQ9Y2G2

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

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BioGRID-ORCSi
22900, 10 hits in 999 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
CARD8, human

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
CARD8

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
22900
PharosiQ9Y2G2, Tbio

Protein Ontology

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PROi
PR:Q9Y2G2
RNActiQ9Y2G2, protein

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
Search...

Gene expression databases

BgeeiENSG00000105483, Expressed in spleen and 217 other tissues
ExpressionAtlasiQ9Y2G2, baseline and differential
GenevisibleiQ9Y2G2, HS

Family and domain databases

InterProiView protein in InterPro
IPR001315, CARD
IPR011029, DEATH-like_dom_sf
IPR025307, FIIND_dom
PfamiView protein in Pfam
PF00619, CARD, 1 hit
PF13553, FIIND, 1 hit
SUPFAMiSSF47986, SSF47986, 1 hit
PROSITEiView protein in PROSITE
PS50209, CARD, 1 hit
PS51830, FIIND, 1 hit

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiCARD8_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9Y2G2
Secondary accession number(s): B5KVR6
, B5KVR8, B7Z496, B7Z4A2, E5RFV9, E9PEM7, G3XAM9, Q6PGP8, Q96P82
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 20, 2001
Last sequence update: June 2, 2021
Last modified: June 2, 2021
This is version 186 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. Human entries with genetic variants
    List of human entries with genetic variants
  3. Human variants curated from literature reports
    Index of human variants curated from literature reports
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
UniProt is an ELIXIR core data resource
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