Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Caspase recruitment domain-containing protein 8

Gene

CARD8

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Inhibits NF-kappa-B activation. May participate in a regulatory mechanism that coordinates cellular responses controlled by NF-kappa-B transcription factor. May be a component of the inflammasome, a protein complex which also includes PYCARD, NALP2 and CASP1 and whose function would be the activation of proinflammatory caspases.

GO - Molecular functioni

  • CARD domain binding Source: UniProtKB
  • cysteine-type endopeptidase activator activity involved in apoptotic process Source: HGNC
  • NACHT domain binding Source: HGNC
  • protein homodimerization activity Source: HGNC

GO - Biological processi

Keywordsi

Biological processApoptosis

Enzyme and pathway databases

SIGNORiQ9Y2G2

Protein family/group databases

MEROPSiS79.001

Names & Taxonomyi

Protein namesi
Recommended name:
Caspase recruitment domain-containing protein 8
Alternative name(s):
Apoptotic protein NDPP1
CARD-inhibitor of NF-kappa-B-activating ligand
Short name:
CARDINAL
DACAR
Tumor up-regulated CARD-containing antagonist of CASP9
Short name:
TUCAN
Gene namesi
Name:CARD8
Synonyms:KIAA0955, NDPP1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

EuPathDBiHostDB:ENSG00000105483.16
HGNCiHGNC:17057 CARD8
MIMi609051 gene
neXtProtiNX_Q9Y2G2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi135E → A: No effect on autocatalytic cleavage. 1 Publication1
Mutagenesisi137E → A: No effect on autocatalytic cleavage. 1 Publication1
Mutagenesisi147H → A: Severe loss of autocatalytic cleavage. 1 Publication1
Mutagenesisi164H → A: Severe loss of autocatalytic cleavage. 1 Publication1
Mutagenesisi173E → A: Partial loss of autocatalytic cleavage. 1 Publication1
Mutagenesisi174H → A: No effect on autocatalytic cleavage. 1 Publication1
Mutagenesisi189S → A: Partial loss of autocatalytic cleavage. 1 Publication1
Mutagenesisi189S → Q: No effect on autocatalytic cleavage. 1 Publication1
Mutagenesisi190F → H: Severe loss of autocatalytic cleavage. 1 Publication1
Mutagenesisi191S → A: Complete loss of autocatalytic cleavage. 1 Publication1
Mutagenesisi227H → A: No effect on autocatalytic cleavage. 1 Publication1
Mutagenesisi366L → R: Inhibits homodimer formation. 1 Publication1

Organism-specific databases

DisGeNETi22900
OpenTargetsiENSG00000105483
PharmGKBiPA134916154

Polymorphism and mutation databases

BioMutaiCARD8
DMDMi14424229

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001440801 – 431Caspase recruitment domain-containing protein 8Add BLAST431

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei190 – 191Cleavage; by autolysisPROSITE-ProRule annotation1 Publication2

Proteomic databases

EPDiQ9Y2G2
PaxDbiQ9Y2G2
PeptideAtlasiQ9Y2G2
PRIDEiQ9Y2G2
ProteomicsDBi85761
85762 [Q9Y2G2-2]
85763 [Q9Y2G2-3]

PTM databases

iPTMnetiQ9Y2G2
PhosphoSitePlusiQ9Y2G2

Expressioni

Tissue specificityi

High expression in lung, ovary, testis and placenta. Lower expression in heart, kidney and liver. Also expressed in spleen, lymph node and bone marrow.

Gene expression databases

BgeeiENSG00000105483 Expressed in 205 organ(s), highest expression level in spleen
CleanExiHS_CARD8
ExpressionAtlasiQ9Y2G2 baseline and differential
GenevisibleiQ9Y2G2 HS

Organism-specific databases

HPAiHPA042071
HPA043513

Interactioni

Subunit structurei

May form homodimers. Interacts with NEMO and DRAL. Binds to caspase-1, CARD16/pseudo-ICE and CARD18/ICEBERG. Interacts with FNBP3 (By similarity). Interacts with NALP2 NACHT domain.By similarity2 Publications

GO - Molecular functioni

Protein-protein interaction databases

BioGridi116564, 45 interactors
CORUMiQ9Y2G2
IntActiQ9Y2G2, 4 interactors
MINTiQ9Y2G2
STRINGi9606.ENSP00000375767

Structurei

Secondary structure

1431
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliQ9Y2G2
SMRiQ9Y2G2
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini56 – 340FIINDPROSITE-ProRule annotationAdd BLAST285
Domaini340 – 430CARDPROSITE-ProRule annotationAdd BLAST91

Phylogenomic databases

eggNOGiKOG3573 Eukaryota
ENOG410ZQIE LUCA
GeneTreeiENSGT00830000128447
HOGENOMiHOG000082406
HOVERGENiHBG050795
InParanoidiQ9Y2G2
KOiK12801
OMAiRDPYLMS
OrthoDBiEOG091G01QH
PhylomeDBiQ9Y2G2
TreeFamiTF352798

Family and domain databases

InterProiView protein in InterPro
IPR001315 CARD
IPR011029 DEATH-like_dom_sf
IPR025307 FIIND_dom
PfamiView protein in Pfam
PF00619 CARD, 1 hit
PF13553 FIIND, 1 hit
SUPFAMiSSF47986 SSF47986, 1 hit
PROSITEiView protein in PROSITE
PS50209 CARD, 1 hit
PS51830 FIIND, 1 hit

Sequences (5+)i

Sequence statusi: Complete.

This entry describes 5 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 5 described isoforms and 10 potential isoforms that are computationally mapped.iShow all

Isoform 1 (identifier: Q9Y2G2-1) [UniParc]FASTAAdd to basket
Also known as: Long

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MMRQRQSHYC SVLFLSVNYL GGTFPGDICS EENQIVSSYA SKVCFEIEED
60 70 80 90 100
YKNRQFLGPE GNVDVELIDK STNRYSVWFP TAGWYLWSAT GLGFLVRDEV
110 120 130 140 150
TVTIAFGSWS QHLALDLQHH EQWLVGGPLF DVTAEPEEAV AEIHLPHFIS
160 170 180 190 200
LQGEVDVSWF LVAHFKNEGM VLEHPARVEP FYAVLESPSF SLMGILLRIA
210 220 230 240 250
SGTRLSIPIT SNTLIYYHPH PEDIKFHLYL VPSDALLTKA IDDEEDRFHG
260 270 280 290 300
VRLQTSPPME PLNFGSSYIV SNSANLKVMP KELKLSYRSP GEIQHFSKFY
310 320 330 340 350
AGQMKEPIQL EITEKRHGTL VWDTEVKPVD LQLVAASAPP PFSGAAFVKE
360 370 380 390 400
NHRQLQARMG DLKGVLDDLQ DNEVLTENEK ELVEQEKTRQ SKNEALLSMV
410 420 430
EKKGDLALDV LFRSISERDP YLVSYLRQQN L
Length:431
Mass (Da):48,933
Last modified:November 1, 1999 - v1
Checksum:iCB54D130807732E6
GO
Isoform 2 (identifier: Q9Y2G2-2) [UniParc]FASTAAdd to basket
Also known as: Short

The sequence of this isoform differs from the canonical sequence as follows:
     282-286: ELKLS → WISSL
     287-431: Missing.

Show »
Length:286
Mass (Da):32,369
Checksum:iE6344DB98904F814
GO
Isoform 3 (identifier: Q9Y2G2-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-25: MMRQRQSHYCSVLFLSVNYLGGTFP → MEKKECPEKS...EQESSEGQDS
     152-152: Q → QA
     282-286: ELKLS → WISSL
     287-431: Missing.

Show »
Length:392
Mass (Da):44,088
Checksum:i69F2C3DF325C3043
GO
Isoform 4 (identifier: Q9Y2G2-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-25: MMRQRQSHYCSVLFLSVNYLGGTFP → MEKKECPEKS...EQESSEGQDS
     152-152: Q → QA

Note: No experimental confirmation available.
Show »
Length:487
Mass (Da):55,109
Checksum:iBE398DFC6F431003
GO
Isoform 5 (identifier: Q9Y2G2-5) [UniParc]FASTAAdd to basket
Also known as: T60

The sequence of this isoform differs from the canonical sequence as follows:
     1-25: MMRQRQSHYCSVLFLSVNYLGGTFP → MEKKECPEKS...EQESSEGQDS
     152-152: Q → QA

Show »
Length:537
Mass (Da):60,652
Checksum:i55775D025C5461BE
GO

Computationally mapped potential isoform sequencesi

There are 10 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E5RFV9E5RFV9_HUMAN
Caspase recruitment domain-containi...
CARD8
70Annotation score:
H0YB90H0YB90_HUMAN
Caspase recruitment domain-containi...
CARD8
70Annotation score:
E5RHZ3E5RHZ3_HUMAN
Caspase recruitment domain-containi...
CARD8
146Annotation score:
E5RFI5E5RFI5_HUMAN
Caspase recruitment domain-containi...
CARD8
132Annotation score:
E5RIN1E5RIN1_HUMAN
Caspase recruitment domain-containi...
CARD8
138Annotation score:
E5RGG3E5RGG3_HUMAN
Caspase recruitment domain-containi...
CARD8
39Annotation score:
E5RGC9E5RGC9_HUMAN
Caspase recruitment domain-containi...
CARD8
82Annotation score:
E5RJG3E5RJG3_HUMAN
Caspase recruitment domain-containi...
CARD8
43Annotation score:
E5RHJ3E5RHJ3_HUMAN
Caspase recruitment domain-containi...
CARD8
132Annotation score:
H0YBW7H0YBW7_HUMAN
Caspase recruitment domain-containi...
CARD8
24Annotation score:

Sequence cautioni

The sequence BAA76799 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti60E → G in AAL02427 (PubMed:11551959).Curated1
Sequence conflicti148F → S in AAH56891 (PubMed:15489334).Curated1
Sequence conflicti219P → R in BAH12488 (PubMed:14702039).Curated1
Sequence conflicti326V → M in AAL02427 (PubMed:11551959).Curated1
Sequence conflicti417E → G in ABW96891 (PubMed:18212821).Curated1
Sequence conflicti422L → P in AAL02427 (PubMed:11551959).Curated1
Isoform 5 (identifier: Q9Y2G2-5)
Sequence conflicti84D → G in ABW96891 (PubMed:18212821).Curated1
Sequence conflicti107E → D in ABW96891 (PubMed:18212821).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_04860668I → V1 PublicationCorresponds to variant dbSNP:rs11881179Ensembl.1
Natural variantiVAR_06107999E → A1 PublicationCorresponds to variant dbSNP:rs59878320Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0127701 – 25MMRQR…GGTFP → MEKKECPEKSSSSEEELPRR DSGSSRNIDASKLIRLQGSR KLLVDNSIRELQYTKTGIFF QAEACVTNDTVYRELPCVSE TLCDISHFFQEDDETEAEPL LFRAVPECQLSGGDIPSVSE EQESSEGQDS in isoform 3 and isoform 5. 3 PublicationsAdd BLAST25
Alternative sequenceiVSP_0452531 – 25MMRQR…GGTFP → MEKKECPEKSSSSEEELPRR VYRELPCVSETLCDISHFFQ EDDETEAEPLLFRAVPECQL SGGDIPSVSEEQESSEGQDS in isoform 4. 1 PublicationAdd BLAST25
Alternative sequenceiVSP_012771152Q → QA in isoform 3, isoform 4 and isoform 5. 3 Publications1
Alternative sequenceiVSP_000782282 – 286ELKLS → WISSL in isoform 2 and isoform 3. 3 Publications5
Alternative sequenceiVSP_000783287 – 431Missing in isoform 2 and isoform 3. 3 PublicationsAdd BLAST145

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB023172 mRNA Translation: BAA76799.2 Different initiation.
AF322184 mRNA Translation: AAG50014.1
AF331519 mRNA Translation: AAK01126.1
AY026322 mRNA Translation: AAK08982.1
AF405558 mRNA Translation: AAL02427.1
EU118120 mRNA Translation: ABW96891.1
AF511652 mRNA Translation: AAM46959.1
AK297045 mRNA Translation: BAH12482.1
AK297069 mRNA Translation: BAH12488.1
AC008392 Genomic DNA No translation available.
AC011466 Genomic DNA No translation available.
CH471177 Genomic DNA Translation: EAW52321.1
CH471177 Genomic DNA Translation: EAW52323.1
BC056891 mRNA Translation: AAH56891.1
CCDSiCCDS12712.2 [Q9Y2G2-4]
CCDS54288.1 [Q9Y2G2-3]
CCDS54289.1 [Q9Y2G2-5]
RefSeqiNP_001171829.1, NM_001184900.1 [Q9Y2G2-5]
NP_001171830.1, NM_001184901.1 [Q9Y2G2-4]
NP_001171831.1, NM_001184902.1 [Q9Y2G2-3]
NP_001171832.1, NM_001184903.1 [Q9Y2G2-3]
NP_055774.2, NM_014959.3 [Q9Y2G2-4]
XP_006723154.1, XM_006723091.3 [Q9Y2G2-5]
XP_006723155.1, XM_006723092.3 [Q9Y2G2-5]
XP_006723156.1, XM_006723093.3 [Q9Y2G2-5]
XP_006723158.1, XM_006723095.3
XP_006723159.1, XM_006723096.3 [Q9Y2G2-4]
XP_006723160.1, XM_006723097.3 [Q9Y2G2-4]
XP_006723167.1, XM_006723104.3 [Q9Y2G2-1]
XP_006723169.1, XM_006723106.3 [Q9Y2G2-3]
XP_006723172.1, XM_006723109.3 [Q9Y2G2-2]
XP_011524943.1, XM_011526641.2 [Q9Y2G2-5]
XP_011524944.1, XM_011526642.2
XP_011524945.1, XM_011526643.2 [Q9Y2G2-5]
XP_011524946.1, XM_011526644.2 [Q9Y2G2-5]
XP_011524952.1, XM_011526650.2 [Q9Y2G2-3]
XP_016881972.1, XM_017026483.1 [Q9Y2G2-4]
XP_016881979.1, XM_017026490.1 [Q9Y2G2-3]
XP_016881987.1, XM_017026498.1 [Q9Y2G2-2]
UniGeneiHs.446146
Hs.655940
Hs.68846

Genome annotation databases

EnsembliENST00000391898; ENSP00000375767; ENSG00000105483 [Q9Y2G2-5]
ENST00000447740; ENSP00000391248; ENSG00000105483 [Q9Y2G2-4]
ENST00000519940; ENSP00000428883; ENSG00000105483 [Q9Y2G2-5]
ENST00000520015; ENSP00000430747; ENSG00000105483 [Q9Y2G2-3]
ENST00000520153; ENSP00000428736; ENSG00000105483 [Q9Y2G2-4]
ENST00000520753; ENSP00000429839; ENSG00000105483 [Q9Y2G2-3]
ENST00000521613; ENSP00000427858; ENSG00000105483 [Q9Y2G2-4]
GeneIDi22900
KEGGihsa:22900
UCSCiuc002pih.5 human [Q9Y2G2-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Cross-referencesi

Web resourcesi

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB023172 mRNA Translation: BAA76799.2 Different initiation.
AF322184 mRNA Translation: AAG50014.1
AF331519 mRNA Translation: AAK01126.1
AY026322 mRNA Translation: AAK08982.1
AF405558 mRNA Translation: AAL02427.1
EU118120 mRNA Translation: ABW96891.1
AF511652 mRNA Translation: AAM46959.1
AK297045 mRNA Translation: BAH12482.1
AK297069 mRNA Translation: BAH12488.1
AC008392 Genomic DNA No translation available.
AC011466 Genomic DNA No translation available.
CH471177 Genomic DNA Translation: EAW52321.1
CH471177 Genomic DNA Translation: EAW52323.1
BC056891 mRNA Translation: AAH56891.1
CCDSiCCDS12712.2 [Q9Y2G2-4]
CCDS54288.1 [Q9Y2G2-3]
CCDS54289.1 [Q9Y2G2-5]
RefSeqiNP_001171829.1, NM_001184900.1 [Q9Y2G2-5]
NP_001171830.1, NM_001184901.1 [Q9Y2G2-4]
NP_001171831.1, NM_001184902.1 [Q9Y2G2-3]
NP_001171832.1, NM_001184903.1 [Q9Y2G2-3]
NP_055774.2, NM_014959.3 [Q9Y2G2-4]
XP_006723154.1, XM_006723091.3 [Q9Y2G2-5]
XP_006723155.1, XM_006723092.3 [Q9Y2G2-5]
XP_006723156.1, XM_006723093.3 [Q9Y2G2-5]
XP_006723158.1, XM_006723095.3
XP_006723159.1, XM_006723096.3 [Q9Y2G2-4]
XP_006723160.1, XM_006723097.3 [Q9Y2G2-4]
XP_006723167.1, XM_006723104.3 [Q9Y2G2-1]
XP_006723169.1, XM_006723106.3 [Q9Y2G2-3]
XP_006723172.1, XM_006723109.3 [Q9Y2G2-2]
XP_011524943.1, XM_011526641.2 [Q9Y2G2-5]
XP_011524944.1, XM_011526642.2
XP_011524945.1, XM_011526643.2 [Q9Y2G2-5]
XP_011524946.1, XM_011526644.2 [Q9Y2G2-5]
XP_011524952.1, XM_011526650.2 [Q9Y2G2-3]
XP_016881972.1, XM_017026483.1 [Q9Y2G2-4]
XP_016881979.1, XM_017026490.1 [Q9Y2G2-3]
XP_016881987.1, XM_017026498.1 [Q9Y2G2-2]
UniGeneiHs.446146
Hs.655940
Hs.68846

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4IKMX-ray2.46A345-431[»]
ProteinModelPortaliQ9Y2G2
SMRiQ9Y2G2
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi116564, 45 interactors
CORUMiQ9Y2G2
IntActiQ9Y2G2, 4 interactors
MINTiQ9Y2G2
STRINGi9606.ENSP00000375767

Protein family/group databases

MEROPSiS79.001

PTM databases

iPTMnetiQ9Y2G2
PhosphoSitePlusiQ9Y2G2

Polymorphism and mutation databases

BioMutaiCARD8
DMDMi14424229

Proteomic databases

EPDiQ9Y2G2
PaxDbiQ9Y2G2
PeptideAtlasiQ9Y2G2
PRIDEiQ9Y2G2
ProteomicsDBi85761
85762 [Q9Y2G2-2]
85763 [Q9Y2G2-3]

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000391898; ENSP00000375767; ENSG00000105483 [Q9Y2G2-5]
ENST00000447740; ENSP00000391248; ENSG00000105483 [Q9Y2G2-4]
ENST00000519940; ENSP00000428883; ENSG00000105483 [Q9Y2G2-5]
ENST00000520015; ENSP00000430747; ENSG00000105483 [Q9Y2G2-3]
ENST00000520153; ENSP00000428736; ENSG00000105483 [Q9Y2G2-4]
ENST00000520753; ENSP00000429839; ENSG00000105483 [Q9Y2G2-3]
ENST00000521613; ENSP00000427858; ENSG00000105483 [Q9Y2G2-4]
GeneIDi22900
KEGGihsa:22900
UCSCiuc002pih.5 human [Q9Y2G2-1]

Organism-specific databases

CTDi22900
DisGeNETi22900
EuPathDBiHostDB:ENSG00000105483.16
GeneCardsiCARD8
H-InvDBiHIX0020041
HGNCiHGNC:17057 CARD8
HPAiHPA042071
HPA043513
MIMi609051 gene
neXtProtiNX_Q9Y2G2
OpenTargetsiENSG00000105483
PharmGKBiPA134916154
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3573 Eukaryota
ENOG410ZQIE LUCA
GeneTreeiENSGT00830000128447
HOGENOMiHOG000082406
HOVERGENiHBG050795
InParanoidiQ9Y2G2
KOiK12801
OMAiRDPYLMS
OrthoDBiEOG091G01QH
PhylomeDBiQ9Y2G2
TreeFamiTF352798

Enzyme and pathway databases

SIGNORiQ9Y2G2

Miscellaneous databases

ChiTaRSiCARD8 human
GeneWikiiCARD8
GenomeRNAii22900
PROiPR:Q9Y2G2
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000105483 Expressed in 205 organ(s), highest expression level in spleen
CleanExiHS_CARD8
ExpressionAtlasiQ9Y2G2 baseline and differential
GenevisibleiQ9Y2G2 HS

Family and domain databases

InterProiView protein in InterPro
IPR001315 CARD
IPR011029 DEATH-like_dom_sf
IPR025307 FIIND_dom
PfamiView protein in Pfam
PF00619 CARD, 1 hit
PF13553 FIIND, 1 hit
SUPFAMiSSF47986 SSF47986, 1 hit
PROSITEiView protein in PROSITE
PS50209 CARD, 1 hit
PS51830 FIIND, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiCARD8_HUMAN
AccessioniPrimary (citable) accession number: Q9Y2G2
Secondary accession number(s): B5KVR6
, B7Z496, B7Z4A2, E9PEM7, G3XAM9, Q6PGP8, Q96P82
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 20, 2001
Last sequence update: November 1, 1999
Last modified: September 12, 2018
This is version 166 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again