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Entry version 182 (07 Oct 2020)
Sequence version 1 (01 Nov 1999)
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Protein

Caspase recruitment domain-containing protein 8

Gene

CARD8

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Inhibits NF-kappa-B activation. May participate in a regulatory mechanism that coordinates cellular responses controlled by NF-kappa-B transcription factor. May be a component of the inflammasome, a protein complex which also includes PYCARD, NALP2 and CASP1 and whose function would be the activation of proinflammatory caspases.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processApoptosis

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...
PathwayCommonsi
Q9Y2G2

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-111458, Formation of apoptosome
R-HSA-9627069, Regulation of the apoptosome activity

SIGNOR Signaling Network Open Resource

More...
SIGNORi
Q9Y2G2

Protein family/group databases

MEROPS protease database

More...
MEROPSi
S79.001

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Caspase recruitment domain-containing protein 8
Alternative name(s):
Apoptotic protein NDPP1
CARD-inhibitor of NF-kappa-B-activating ligand
Short name:
CARDINAL
DACAR
Tumor up-regulated CARD-containing antagonist of CASP9
Short name:
TUCAN
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:CARD8
Synonyms:KIAA0955, NDPP1
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 19

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000105483.16

Human Gene Nomenclature Database

More...
HGNCi
HGNC:17057, CARD8

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
609051, gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q9Y2G2

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology%5Fand%5Fbiotech%5Fsection">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi135E → A: No effect on autocatalytic cleavage. 1 Publication1
Mutagenesisi137E → A: No effect on autocatalytic cleavage. 1 Publication1
Mutagenesisi147H → A: Severe loss of autocatalytic cleavage. 1 Publication1
Mutagenesisi164H → A: Severe loss of autocatalytic cleavage. 1 Publication1
Mutagenesisi173E → A: Partial loss of autocatalytic cleavage. 1 Publication1
Mutagenesisi174H → A: No effect on autocatalytic cleavage. 1 Publication1
Mutagenesisi189S → A: Partial loss of autocatalytic cleavage. 1 Publication1
Mutagenesisi189S → Q: No effect on autocatalytic cleavage. 1 Publication1
Mutagenesisi190F → H: Severe loss of autocatalytic cleavage. 1 Publication1
Mutagenesisi191S → A: Complete loss of autocatalytic cleavage. 1 Publication1
Mutagenesisi227H → A: No effect on autocatalytic cleavage. 1 Publication1
Mutagenesisi366L → R: Inhibits homodimer formation. 1 Publication1

Organism-specific databases

DisGeNET

More...
DisGeNETi
22900

Open Targets

More...
OpenTargetsi
ENSG00000105483

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA134916154

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q9Y2G2, Tbio

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
CARD8

Domain mapping of disease mutations (DMDM)

More...
DMDMi
14424229

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001440801 – 431Caspase recruitment domain-containing protein 8Add BLAST431

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection describes interesting single amino acid sites on the sequence that are not defined in any other subsection. This subsection can be displayed in different sections ('Function', 'PTM / Processing', 'Pathology and Biotech') according to its content.<p><a href='/help/site' target='_top'>More...</a></p>Sitei190 – 191Cleavage; by autolysisPROSITE-ProRule annotation1 Publication2

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q9Y2G2

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
Q9Y2G2

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q9Y2G2

PeptideAtlas

More...
PeptideAtlasi
Q9Y2G2

PRoteomics IDEntifications database

More...
PRIDEi
Q9Y2G2

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
19923
33792
85761 [Q9Y2G2-1]
85762 [Q9Y2G2-2]
85763 [Q9Y2G2-3]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q9Y2G2

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q9Y2G2

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

High expression in lung, ovary, testis and placenta. Lower expression in heart, kidney and liver. Also expressed in spleen, lymph node and bone marrow.

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000105483, Expressed in spleen and 217 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q9Y2G2, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q9Y2G2, HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
ENSG00000105483, Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

May form homodimers.

Interacts with NEMO and DRAL. Binds to caspase-1, CARD16/pseudo-ICE and CARD18/ICEBERG.

Interacts with FNBP3 (By similarity).

Interacts with NALP2 NACHT domain.

By similarity2 Publications

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
116564, 47 interactors

CORUM comprehensive resource of mammalian protein complexes

More...
CORUMi
Q9Y2G2

Protein interaction database and analysis system

More...
IntActi
Q9Y2G2, 37 interactors

Molecular INTeraction database

More...
MINTi
Q9Y2G2

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000375767

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q9Y2G2, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1431
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q9Y2G2

Database of comparative protein structure models

More...
ModBasei
Search...

Protein Data Bank in Europe - Knowledge Base

More...
PDBe-KBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini56 – 340FIINDPROSITE-ProRule annotationAdd BLAST285
Domaini340 – 430CARDPROSITE-ProRule annotationAdd BLAST91

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG3573, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00830000128447

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_037186_1_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q9Y2G2

KEGG Orthology (KO)

More...
KOi
K12801

Identification of Orthologs from Complete Genome Data

More...
OMAi
MEPLNFG

Database of Orthologous Groups

More...
OrthoDBi
559093at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q9Y2G2

TreeFam database of animal gene trees

More...
TreeFami
TF352798

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR001315, CARD
IPR011029, DEATH-like_dom_sf
IPR025307, FIIND_dom

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00619, CARD, 1 hit
PF13553, FIIND, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF47986, SSF47986, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50209, CARD, 1 hit
PS51830, FIIND, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (5+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 5 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 5 described isoforms and 10 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q9Y2G2-1) [UniParc]FASTAAdd to basket
Also known as: Long

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MMRQRQSHYC SVLFLSVNYL GGTFPGDICS EENQIVSSYA SKVCFEIEED
60 70 80 90 100
YKNRQFLGPE GNVDVELIDK STNRYSVWFP TAGWYLWSAT GLGFLVRDEV
110 120 130 140 150
TVTIAFGSWS QHLALDLQHH EQWLVGGPLF DVTAEPEEAV AEIHLPHFIS
160 170 180 190 200
LQGEVDVSWF LVAHFKNEGM VLEHPARVEP FYAVLESPSF SLMGILLRIA
210 220 230 240 250
SGTRLSIPIT SNTLIYYHPH PEDIKFHLYL VPSDALLTKA IDDEEDRFHG
260 270 280 290 300
VRLQTSPPME PLNFGSSYIV SNSANLKVMP KELKLSYRSP GEIQHFSKFY
310 320 330 340 350
AGQMKEPIQL EITEKRHGTL VWDTEVKPVD LQLVAASAPP PFSGAAFVKE
360 370 380 390 400
NHRQLQARMG DLKGVLDDLQ DNEVLTENEK ELVEQEKTRQ SKNEALLSMV
410 420 430
EKKGDLALDV LFRSISERDP YLVSYLRQQN L
Length:431
Mass (Da):48,933
Last modified:November 1, 1999 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iCB54D130807732E6
GO
Isoform 2 (identifier: Q9Y2G2-2) [UniParc]FASTAAdd to basket
Also known as: Short

The sequence of this isoform differs from the canonical sequence as follows:
     282-286: ELKLS → WISSL
     287-431: Missing.

Show »
Length:286
Mass (Da):32,369
Checksum:iE6344DB98904F814
GO
Isoform 3 (identifier: Q9Y2G2-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-25: MMRQRQSHYCSVLFLSVNYLGGTFP → MEKKECPEKS...EQESSEGQDS
     152-152: Q → QA
     282-286: ELKLS → WISSL
     287-431: Missing.

Show »
Length:392
Mass (Da):44,088
Checksum:i69F2C3DF325C3043
GO
Isoform 4 (identifier: Q9Y2G2-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-25: MMRQRQSHYCSVLFLSVNYLGGTFP → MEKKECPEKS...EQESSEGQDS
     152-152: Q → QA

Show »
Length:487
Mass (Da):55,109
Checksum:iBE398DFC6F431003
GO
Isoform 5 (identifier: Q9Y2G2-5) [UniParc]FASTAAdd to basket
Also known as: T60

The sequence of this isoform differs from the canonical sequence as follows:
     1-25: MMRQRQSHYCSVLFLSVNYLGGTFP → MEKKECPEKS...EQESSEGQDS
     152-152: Q → QA

Show »
Length:537
Mass (Da):60,652
Checksum:i55775D025C5461BE
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 10 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E5RFV9E5RFV9_HUMAN
Caspase recruitment domain-containi...
CARD8
70Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E5RGG3E5RGG3_HUMAN
Caspase recruitment domain-containi...
CARD8
39Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E5RHJ3E5RHJ3_HUMAN
Caspase recruitment domain-containi...
CARD8
132Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E5RHZ3E5RHZ3_HUMAN
Caspase recruitment domain-containi...
CARD8
146Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E5RFI5E5RFI5_HUMAN
Caspase recruitment domain-containi...
CARD8
132Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0YB90H0YB90_HUMAN
Caspase recruitment domain-containi...
CARD8
70Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E5RIN1E5RIN1_HUMAN
Caspase recruitment domain-containi...
CARD8
138Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E5RJG3E5RJG3_HUMAN
Caspase recruitment domain-containi...
CARD8
43Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0YBW7H0YBW7_HUMAN
Caspase recruitment domain-containi...
CARD8
24Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E5RGC9E5RGC9_HUMAN
Caspase recruitment domain-containi...
CARD8
82Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence BAA76799 differs from that shown. Reason: Erroneous initiation. Extended N-terminus.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti60E → G in AAL02427 (PubMed:11551959).Curated1
Sequence conflicti148F → S in AAH56891 (PubMed:15489334).Curated1
Sequence conflicti219P → R in BAH12488 (PubMed:14702039).Curated1
Sequence conflicti326V → M in AAL02427 (PubMed:11551959).Curated1
Sequence conflicti417E → G in ABW96891 (PubMed:18212821).Curated1
Sequence conflicti422L → P in AAL02427 (PubMed:11551959).Curated1
Isoform 5 (identifier: Q9Y2G2-5)
Sequence conflicti84D → G in ABW96891 (PubMed:18212821).Curated1
Sequence conflicti107E → D in ABW96891 (PubMed:18212821).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_04860668I → V1 PublicationCorresponds to variant dbSNP:rs11881179Ensembl.1
Natural variantiVAR_06107999E → A1 PublicationCorresponds to variant dbSNP:rs59878320Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0127701 – 25MMRQR…GGTFP → MEKKECPEKSSSSEEELPRR DSGSSRNIDASKLIRLQGSR KLLVDNSIRELQYTKTGIFF QAEACVTNDTVYRELPCVSE TLCDISHFFQEDDETEAEPL LFRAVPECQLSGGDIPSVSE EQESSEGQDS in isoform 3 and isoform 5. 3 PublicationsAdd BLAST25
Alternative sequenceiVSP_0452531 – 25MMRQR…GGTFP → MEKKECPEKSSSSEEELPRR VYRELPCVSETLCDISHFFQ EDDETEAEPLLFRAVPECQL SGGDIPSVSEEQESSEGQDS in isoform 4. 1 PublicationAdd BLAST25
Alternative sequenceiVSP_012771152Q → QA in isoform 3, isoform 4 and isoform 5. 3 Publications1
Alternative sequenceiVSP_000782282 – 286ELKLS → WISSL in isoform 2 and isoform 3. 3 Publications5
Alternative sequenceiVSP_000783287 – 431Missing in isoform 2 and isoform 3. 3 PublicationsAdd BLAST145

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AB023172 mRNA Translation: BAA76799.2 Different initiation.
AF322184 mRNA Translation: AAG50014.1
AF331519 mRNA Translation: AAK01126.1
AY026322 mRNA Translation: AAK08982.1
AF405558 mRNA Translation: AAL02427.1
EU118120 mRNA Translation: ABW96891.1
AF511652 mRNA Translation: AAM46959.1
AK297045 mRNA Translation: BAH12482.1
AK297069 mRNA Translation: BAH12488.1
AC008392 Genomic DNA No translation available.
AC011466 Genomic DNA No translation available.
CH471177 Genomic DNA Translation: EAW52321.1
CH471177 Genomic DNA Translation: EAW52323.1
BC056891 mRNA Translation: AAH56891.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS12712.2 [Q9Y2G2-4]
CCDS54288.1 [Q9Y2G2-3]
CCDS54289.1 [Q9Y2G2-5]

NCBI Reference Sequences

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RefSeqi
NP_001171829.1, NM_001184900.1 [Q9Y2G2-5]
NP_001171830.1, NM_001184901.1 [Q9Y2G2-4]
NP_001171831.1, NM_001184902.1 [Q9Y2G2-3]
NP_001171832.1, NM_001184903.1 [Q9Y2G2-3]
NP_055774.2, NM_014959.3 [Q9Y2G2-4]
XP_006723154.1, XM_006723091.3 [Q9Y2G2-5]
XP_006723155.1, XM_006723092.3 [Q9Y2G2-5]
XP_006723156.1, XM_006723093.3 [Q9Y2G2-5]
XP_006723158.1, XM_006723095.3
XP_006723159.1, XM_006723096.3 [Q9Y2G2-4]
XP_006723160.1, XM_006723097.3 [Q9Y2G2-4]
XP_006723167.1, XM_006723104.3 [Q9Y2G2-1]
XP_006723169.1, XM_006723106.3 [Q9Y2G2-3]
XP_006723172.1, XM_006723109.3 [Q9Y2G2-2]
XP_011524943.1, XM_011526641.2 [Q9Y2G2-5]
XP_011524944.1, XM_011526642.2
XP_011524945.1, XM_011526643.2 [Q9Y2G2-5]
XP_011524946.1, XM_011526644.2 [Q9Y2G2-5]
XP_011524952.1, XM_011526650.2 [Q9Y2G2-3]
XP_016881972.1, XM_017026483.1 [Q9Y2G2-4]
XP_016881979.1, XM_017026490.1
XP_016881987.1, XM_017026498.1 [Q9Y2G2-2]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000391898; ENSP00000375767; ENSG00000105483 [Q9Y2G2-5]
ENST00000447740; ENSP00000391248; ENSG00000105483 [Q9Y2G2-4]
ENST00000519940; ENSP00000428883; ENSG00000105483 [Q9Y2G2-5]
ENST00000520015; ENSP00000430747; ENSG00000105483 [Q9Y2G2-3]
ENST00000520153; ENSP00000428736; ENSG00000105483 [Q9Y2G2-4]
ENST00000520753; ENSP00000429839; ENSG00000105483 [Q9Y2G2-3]
ENST00000521613; ENSP00000427858; ENSG00000105483 [Q9Y2G2-4]
ENST00000651546; ENSP00000499211; ENSG00000105483 [Q9Y2G2-5]

Database of genes from NCBI RefSeq genomes

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GeneIDi
22900

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:22900

UCSC genome browser

More...
UCSCi
uc002pih.5, human [Q9Y2G2-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross%5Freferences%5Fsection">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB023172 mRNA Translation: BAA76799.2 Different initiation.
AF322184 mRNA Translation: AAG50014.1
AF331519 mRNA Translation: AAK01126.1
AY026322 mRNA Translation: AAK08982.1
AF405558 mRNA Translation: AAL02427.1
EU118120 mRNA Translation: ABW96891.1
AF511652 mRNA Translation: AAM46959.1
AK297045 mRNA Translation: BAH12482.1
AK297069 mRNA Translation: BAH12488.1
AC008392 Genomic DNA No translation available.
AC011466 Genomic DNA No translation available.
CH471177 Genomic DNA Translation: EAW52321.1
CH471177 Genomic DNA Translation: EAW52323.1
BC056891 mRNA Translation: AAH56891.1
CCDSiCCDS12712.2 [Q9Y2G2-4]
CCDS54288.1 [Q9Y2G2-3]
CCDS54289.1 [Q9Y2G2-5]
RefSeqiNP_001171829.1, NM_001184900.1 [Q9Y2G2-5]
NP_001171830.1, NM_001184901.1 [Q9Y2G2-4]
NP_001171831.1, NM_001184902.1 [Q9Y2G2-3]
NP_001171832.1, NM_001184903.1 [Q9Y2G2-3]
NP_055774.2, NM_014959.3 [Q9Y2G2-4]
XP_006723154.1, XM_006723091.3 [Q9Y2G2-5]
XP_006723155.1, XM_006723092.3 [Q9Y2G2-5]
XP_006723156.1, XM_006723093.3 [Q9Y2G2-5]
XP_006723158.1, XM_006723095.3
XP_006723159.1, XM_006723096.3 [Q9Y2G2-4]
XP_006723160.1, XM_006723097.3 [Q9Y2G2-4]
XP_006723167.1, XM_006723104.3 [Q9Y2G2-1]
XP_006723169.1, XM_006723106.3 [Q9Y2G2-3]
XP_006723172.1, XM_006723109.3 [Q9Y2G2-2]
XP_011524943.1, XM_011526641.2 [Q9Y2G2-5]
XP_011524944.1, XM_011526642.2
XP_011524945.1, XM_011526643.2 [Q9Y2G2-5]
XP_011524946.1, XM_011526644.2 [Q9Y2G2-5]
XP_011524952.1, XM_011526650.2 [Q9Y2G2-3]
XP_016881972.1, XM_017026483.1 [Q9Y2G2-4]
XP_016881979.1, XM_017026490.1
XP_016881987.1, XM_017026498.1 [Q9Y2G2-2]

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...
PDBei

Protein Data Bank RCSB

More...
RCSB PDBi

Protein Data Bank Japan

More...
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4IKMX-ray2.46A345-431[»]
SMRiQ9Y2G2
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi116564, 47 interactors
CORUMiQ9Y2G2
IntActiQ9Y2G2, 37 interactors
MINTiQ9Y2G2
STRINGi9606.ENSP00000375767

Protein family/group databases

MEROPSiS79.001

PTM databases

iPTMnetiQ9Y2G2
PhosphoSitePlusiQ9Y2G2

Polymorphism and mutation databases

BioMutaiCARD8
DMDMi14424229

Proteomic databases

EPDiQ9Y2G2
MassIVEiQ9Y2G2
PaxDbiQ9Y2G2
PeptideAtlasiQ9Y2G2
PRIDEiQ9Y2G2
ProteomicsDBi19923
33792
85761 [Q9Y2G2-1]
85762 [Q9Y2G2-2]
85763 [Q9Y2G2-3]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...
Antibodypediai
18287, 301 antibodies

Genome annotation databases

EnsembliENST00000391898; ENSP00000375767; ENSG00000105483 [Q9Y2G2-5]
ENST00000447740; ENSP00000391248; ENSG00000105483 [Q9Y2G2-4]
ENST00000519940; ENSP00000428883; ENSG00000105483 [Q9Y2G2-5]
ENST00000520015; ENSP00000430747; ENSG00000105483 [Q9Y2G2-3]
ENST00000520153; ENSP00000428736; ENSG00000105483 [Q9Y2G2-4]
ENST00000520753; ENSP00000429839; ENSG00000105483 [Q9Y2G2-3]
ENST00000521613; ENSP00000427858; ENSG00000105483 [Q9Y2G2-4]
ENST00000651546; ENSP00000499211; ENSG00000105483 [Q9Y2G2-5]
GeneIDi22900
KEGGihsa:22900
UCSCiuc002pih.5, human [Q9Y2G2-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
22900
DisGeNETi22900
EuPathDBiHostDB:ENSG00000105483.16

GeneCards: human genes, protein and diseases

More...
GeneCardsi
CARD8
HGNCiHGNC:17057, CARD8
HPAiENSG00000105483, Low tissue specificity
MIMi609051, gene
neXtProtiNX_Q9Y2G2
OpenTargetsiENSG00000105483
PharmGKBiPA134916154

Human Unidentified Gene-Encoded large proteins database

More...
HUGEi
Search...

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG3573, Eukaryota
GeneTreeiENSGT00830000128447
HOGENOMiCLU_037186_1_0_1
InParanoidiQ9Y2G2
KOiK12801
OMAiMEPLNFG
OrthoDBi559093at2759
PhylomeDBiQ9Y2G2
TreeFamiTF352798

Enzyme and pathway databases

PathwayCommonsiQ9Y2G2
ReactomeiR-HSA-111458, Formation of apoptosome
R-HSA-9627069, Regulation of the apoptosome activity
SIGNORiQ9Y2G2

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...
BioGRID-ORCSi
22900, 9 hits in 876 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
CARD8, human

The Gene Wiki collection of pages on human genes and proteins

More...
GeneWikii
CARD8

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
22900
PharosiQ9Y2G2, Tbio

Protein Ontology

More...
PROi
PR:Q9Y2G2
RNActiQ9Y2G2, protein

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000105483, Expressed in spleen and 217 other tissues
ExpressionAtlasiQ9Y2G2, baseline and differential
GenevisibleiQ9Y2G2, HS

Family and domain databases

InterProiView protein in InterPro
IPR001315, CARD
IPR011029, DEATH-like_dom_sf
IPR025307, FIIND_dom
PfamiView protein in Pfam
PF00619, CARD, 1 hit
PF13553, FIIND, 1 hit
SUPFAMiSSF47986, SSF47986, 1 hit
PROSITEiView protein in PROSITE
PS50209, CARD, 1 hit
PS51830, FIIND, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiCARD8_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9Y2G2
Secondary accession number(s): B5KVR6
, B7Z496, B7Z4A2, E9PEM7, G3XAM9, Q6PGP8, Q96P82
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 20, 2001
Last sequence update: November 1, 1999
Last modified: October 7, 2020
This is version 182 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  5. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
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