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Entry version 121 (08 May 2019)
Sequence version 5 (18 May 2010)
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Protein

Little elongation complex subunit 1

Gene

ICE1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Component of the little elongation complex (LEC), a complex required to regulate small nuclear RNA (snRNA) gene transcription by RNA polymerase II and III (PubMed:22195968, PubMed:23932780). Specifically acts as a scaffold protein that promotes the LEC complex formation and recruitment and RNA polymerase II occupancy at snRNA genes in subnuclear bodies (PubMed:23932780).2 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processTranscription, Transcription regulation

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-6807505 RNA polymerase II transcribes snRNA genes

SIGNOR Signaling Network Open Resource

More...
SIGNORi
Q9Y2F5

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Little elongation complex subunit 1
Alternative name(s):
Interactor of little elongator complex ELL subunit 1
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:ICE1
Synonyms:KIAA0947
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 5

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:29154 ICE1

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
617958 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q9Y2F5

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
23379

Open Targets

More...
OpenTargetsi
ENSG00000164151

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA162411094

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
ICE1

Domain mapping of disease mutations (DMDM)

More...
DMDMi
296439500

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002957241 – 2266Little elongation complex subunit 1Add BLAST2266

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei255PhosphoserineCombined sources1
Modified residuei533PhosphoserineCombined sources1
Modified residuei558PhosphoserineCombined sources1
Modified residuei589PhosphoserineCombined sources1
Modified residuei707PhosphoserineBy similarity1
Modified residuei832PhosphothreonineCombined sources1
Modified residuei925PhosphoserineCombined sources1
Modified residuei958PhosphoserineCombined sources1
Modified residuei1218N6-acetyllysineCombined sources1
Modified residuei1588PhosphoserineCombined sources1
Modified residuei1617PhosphoserineBy similarity1
Modified residuei1642PhosphothreonineCombined sources1
Modified residuei1692PhosphoserineCombined sources1
Modified residuei1697PhosphoserineCombined sources1
Modified residuei1699PhosphoserineCombined sources1
Modified residuei1701PhosphoserineCombined sources1
Modified residuei1712PhosphoserineCombined sources1
Modified residuei1838PhosphoserineCombined sources1
Modified residuei1854PhosphoserineCombined sources1
Modified residuei1903PhosphoserineCombined sources1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

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EPDi
Q9Y2F5

jPOST - Japan Proteome Standard Repository/Database

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jPOSTi
Q9Y2F5

MaxQB - The MaxQuant DataBase

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MaxQBi
Q9Y2F5

PaxDb, a database of protein abundance averages across all three domains of life

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PaxDbi
Q9Y2F5

PeptideAtlas

More...
PeptideAtlasi
Q9Y2F5

PRoteomics IDEntifications database

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PRIDEi
Q9Y2F5

ProteomicsDB human proteome resource

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ProteomicsDBi
85753

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

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iPTMneti
Q9Y2F5

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q9Y2F5

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

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Bgeei
ENSG00000164151 Expressed in 239 organ(s), highest expression level in female gonad

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
Q9Y2F5 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
Q9Y2F5 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA054452
HPA061934

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Component of the little elongation complex (LEC), at least composed of ELL (ELL, ELL2 or ELL3), ZC3H8, ICE1 and ICE2.

Interacts (via N-terminus domain) with ELL.

Interacts (via C-terminus domain) with ICE2 and ZC3H8.

2 Publications

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

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BioGridi
116955, 23 interactors

Protein interaction database and analysis system

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IntActi
Q9Y2F5, 19 interactors

Molecular INTeraction database

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MINTi
Q9Y2F5

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000296564

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
Q9Y2F5

Database of comparative protein structure models

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ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and domains’ section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili23 – 186Sequence analysisAdd BLAST164

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi340 – 367Pro-richAdd BLAST28
Compositional biasi1630 – 1733Pro-richAdd BLAST104

<p>This subsection of the ‘Family and domains’ section provides general information on the biological role of a domain. The term ‘domain’ is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The N-termimus domain is necessary and sufficient for its targeting to subnuclear cajal and histone locus bodies.1 Publication

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the ICE1 family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410IE47 Eukaryota
ENOG4111F6B LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00950000183199

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000168419

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
Q9Y2F5

Identification of Orthologs from Complete Genome Data

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OMAi
GQISPLC

Database of Orthologous Groups

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OrthoDBi
265329at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q9Y2F5

TreeFam database of animal gene trees

More...
TreeFami
TF330760

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

Q9Y2F5-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MMPGETHSAA PGTAADLSRC QGCASLQQNL NEYVEALITL KQKIINTDNL
60 70 80 90 100
LTEYQKKCDE LQFARRENSN LHHQVEEMLQ KISPLQKCQE ELGSLKAELE
110 120 130 140 150
EKKSSLKLYQ DTHQEYARVK EECLKSDAQK KKLEAKVKKL QEAAVKQTQD
160 170 180 190 200
FKQLRNEKKI LEKEFKKTQE RLDEFSKQKN EKELRHIGTQ ISSDSYGSID
210 220 230 240 250
KRKVKLLLKE LWLCVNTTHR LPGEGSRCVP EKPAKAITSS RVPGEDGTLP
260 270 280 290 300
PTQGSPLRTS NVQTCLTKLS MEIKEDFLCQ NVEKQSSSGT NCSSDHVFNE
310 320 330 340 350
NGNLEVLVQS HRDGGSTEFV DHDHFFDEDL QAAIDFFKLP PPLLSPVPSP
360 370 380 390 400
PPMSSPHPGS LPSSFAPETY FGEYTDSSDN DSVQLRNSAE CVSEDDTTES
410 420 430 440 450
QNYFGSLRKN KGSGTWEEKP KSHEAIQALN TWEVNKVTTS GLETFTATLR
460 470 480 490 500
ESSATHSLVG EKHWTTASRS MSDRKRDILH ETKTQMEVRE MDKSVQTEKT
510 520 530 540 550
IHKLTRGLCI ERLSASPAQE KEAAPGKSEL CSSPLGKRPL NELMESEGKT
560 570 580 590 600
VLSKMMGSPK SEFTKWTRIN EITSEPDRIT VSGHFHRLSR ELEKEKEDTQ
610 620 630 640 650
GFTLGESPES EDDDSGDGMD VAGLDIETSF SSSSTLVALS VGSNPQSSSG
660 670 680 690 700
LDCGNDTDIT TKVFSTEPHH SEHKLQTKTL NTLHLQSEPP ECSIGGNNLE
710 720 730 740 750
NSLCALSPEL GASNFNDQKS SGIEYTKVVK GLTKIHSLPR SVFMKATKDG
760 770 780 790 800
QCESQDPRIE LTLNKPDFTS LIGSQAALIK SGLGFVKSTS WHHSDLLRKG
810 820 830 840 850
GEESLRAKSE HEQKTSHQLQ KAMPFLQNRG PTPKPDLLRE NNNPVEFKTT
860 870 880 890 900
ASVLPNQVSV ITKQTRPEKV QSAKLEHLRP HRVEPTLVTE NSGNKTGMST
910 920 930 940 950
VAKCDGERDD TTQNITEVAA VKSISPEVSA SRRKLDFNSP GGSSPVENSD
960 970 980 990 1000
CSTNSRLSFS PENILIQNQD IVREAAVQGD GQKQRQPQAT DLDSSGTHGS
1010 1020 1030 1040 1050
EMLPATEVTV SGGFSVEETS CGDTGRSGGE ALAVANDSTS TPQNANGLWK
1060 1070 1080 1090 1100
LKSTTPGGAL PECFGTTDTT FSSAFCRKHG ETQDTSQSSL PGTLHCYTGI
1110 1120 1130 1140 1150
REGGDDTEVE SEAFSCSEGS EQQDAPDDSQ KNLGDTDAAV AEVRPSLEVG
1160 1170 1180 1190 1200
YLTSALQDFN ISTFSELDRL STSEVVMFLE SCQLGDYSSG DSVSECSSKG
1210 1220 1230 1240 1250
TLSKEMNKEL KASEIGEKYR KQPCEEETLG TCEEWIESEE DDYSLKNTSQ
1260 1270 1280 1290 1300
LTQCSLETLS EVLTKIRQEL QTNSEDCNGK DTGSLLLLNV NNNMTTENLK
1310 1320 1330 1340 1350
EKSPFRETTG SSSHASEPTP QAAALDTEGS SPISGMPQNE NPQSRPEARS
1360 1370 1380 1390 1400
DAGRQTDGGE EDLPEPVEPS ALCSDSVMEP SIEQSSNCEA ETTFQCQIAT
1410 1420 1430 1440 1450
VTSEVINVLI NKDQNLVIEK GDNWTIISGV AVLPHVDQVT LCDIPGDIPI
1460 1470 1480 1490 1500
SQDQGELEAG CIPVTSAEKS PEASHTGPAF QEAPCGNNLS CPQEDVSSSG
1510 1520 1530 1540 1550
QSTNFDKSRL RNRPVKPSIW ISSQIYDQNF ETQIVASDHT YYNSKLEPSG
1560 1570 1580 1590 1600
KNKNRSKISN KDQSNKPVKT SASSRVETHQ SEVAQSFSGE KANTKTQRSQ
1610 1620 1630 1640 1650
TQTILANADT STPTDCSPDT LSKIRQEVGP PLPPLLAPLI ATPPRTSQPL
1660 1670 1680 1690 1700
SPLISSSSPS SPASPVGQVS PFRETPVPPA MSPWPEDPRR ASPPDPSPSP
1710 1720 1730 1740 1750
SAASASERVV PSPLQFCAAT PKHALPVPGR LPPCASGHAA VGGPQENSVK
1760 1770 1780 1790 1800
ILDTMYPELS ARARTLNILK GNIQLTRGPP ADCKNLPGPA SAMIGFKTIT
1810 1820 1830 1840 1850
SAATAFVKTG SSSGGDCNQD KSRDLGTQQD SSGKRTLSTS TLRSAKRLRL
1860 1870 1880 1890 1900
DTGSPEPETR GVTAEGIHKN LPGNLPPAEV ATTNEERSCS SPAVSAVSQL
1910 1920 1930 1940 1950
PLSPKETVES HDKAIANALK KIAEFSFDLL PVIRSHVYVG NISKKPVMRD
1960 1970 1980 1990 2000
QEKEVVYEFS TTKKHLAECL LHSILSELKI QKISMDHNYI HALCRVYVGI
2010 2020 2030 2040 2050
CRQLGDLERA RLFCYSLLKE DFPESEKLTL FIANMWHDIF LSQSVINKAM
2060 2070 2080 2090 2100
QLVARQRAKG EVLNCLRAFL NWEKNAPVDV GFMVSKLLLT IQLCPKTEFQ
2110 2120 2130 2140 2150
PSEKFGEDLS DNTWEYIFAI DLLCCHQKWI WTHDNIISKE LWPVMDKWIK
2160 2170 2180 2190 2200
YRKGHANIAY TPDIIIASIL RLIGRLGQLG LKEGFPSAVK NISSVIGMFI
2210 2220 2230 2240 2250
QHAHDEDIPW GIQLAAVYAL CDLSPSNPAE ISKILEAWRR EASKSVPSAI
2260
VSCLEEVSAL STEELG
Length:2,266
Mass (Da):247,891
Last modified:May 18, 2010 - v5
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i69EC121F4543B92D
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A096LPH9A0A096LPH9_HUMAN
Little elongation complex subunit 1
ICE1
145Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence BAA76791 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated
The sequence BAC86755 differs from that shown. Aberrant splicing.Curated
The sequence CAB70661 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence CAB70661 differs from that shown. Reason: Erroneous termination at position 2051. Translated as Gln.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti465T → S in BAC86755 (PubMed:14702039).Curated1
Sequence conflicti757P → G in CAD97966 (PubMed:17974005).Curated1
Sequence conflicti821K → R in CAH18279 (PubMed:17974005).Curated1
Sequence conflicti1112E → V in CAH18279 (PubMed:17974005).Curated1
Sequence conflicti1186D → G in CAD97966 (PubMed:17974005).Curated1
Sequence conflicti1756Y → F in CAD97966 (PubMed:17974005).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_033341391C → S2 PublicationsCorresponds to variant dbSNP:rs2619844Ensembl.1
Natural variantiVAR_033342596K → E. Corresponds to variant dbSNP:rs10475299Ensembl.1
Natural variantiVAR_033343901V → I3 PublicationsCorresponds to variant dbSNP:rs2578500Ensembl.1
Natural variantiVAR_0333441054T → A. Corresponds to variant dbSNP:rs3806873Ensembl.1
Natural variantiVAR_0333451058G → D. Corresponds to variant dbSNP:rs3806874Ensembl.1
Natural variantiVAR_0333461597Q → P. Corresponds to variant dbSNP:rs10065646Ensembl.1
Natural variantiVAR_0559431618P → L. Corresponds to variant dbSNP:rs3747731Ensembl.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
AB023164 mRNA Translation: BAA76791.3 Different initiation.
AC010253 Genomic DNA No translation available.
AC012607 Genomic DNA No translation available.
AK126937 mRNA Translation: BAC86755.1 Sequence problems.
AL137260 mRNA Translation: CAB70661.1 Sequence problems.
BX538020 mRNA Translation: CAD97966.1
CR749441 mRNA Translation: CAH18279.1
BC004902 mRNA Translation: AAH04902.2

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS47187.1

Protein sequence database of the Protein Information Resource

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PIRi
T46331

NCBI Reference Sequences

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RefSeqi
NP_056140.1, NM_015325.2

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENST00000296564; ENSP00000296564; ENSG00000164151

Database of genes from NCBI RefSeq genomes

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GeneIDi
23379

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:23379

UCSC genome browser

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UCSCi
uc003jdm.6 human

Keywords - Coding sequence diversityi

Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB023164 mRNA Translation: BAA76791.3 Different initiation.
AC010253 Genomic DNA No translation available.
AC012607 Genomic DNA No translation available.
AK126937 mRNA Translation: BAC86755.1 Sequence problems.
AL137260 mRNA Translation: CAB70661.1 Sequence problems.
BX538020 mRNA Translation: CAD97966.1
CR749441 mRNA Translation: CAH18279.1
BC004902 mRNA Translation: AAH04902.2
CCDSiCCDS47187.1
PIRiT46331
RefSeqiNP_056140.1, NM_015325.2

3D structure databases

SMRiQ9Y2F5
ModBaseiSearch...

Protein-protein interaction databases

BioGridi116955, 23 interactors
IntActiQ9Y2F5, 19 interactors
MINTiQ9Y2F5
STRINGi9606.ENSP00000296564

PTM databases

iPTMnetiQ9Y2F5
PhosphoSitePlusiQ9Y2F5

Polymorphism and mutation databases

BioMutaiICE1
DMDMi296439500

Proteomic databases

EPDiQ9Y2F5
jPOSTiQ9Y2F5
MaxQBiQ9Y2F5
PaxDbiQ9Y2F5
PeptideAtlasiQ9Y2F5
PRIDEiQ9Y2F5
ProteomicsDBi85753

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000296564; ENSP00000296564; ENSG00000164151
GeneIDi23379
KEGGihsa:23379
UCSCiuc003jdm.6 human

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
23379
DisGeNETi23379

GeneCards: human genes, protein and diseases

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GeneCardsi
ICE1
HGNCiHGNC:29154 ICE1
HPAiHPA054452
HPA061934
MIMi617958 gene
neXtProtiNX_Q9Y2F5
OpenTargetsiENSG00000164151
PharmGKBiPA162411094

Human Unidentified Gene-Encoded large proteins database

More...
HUGEi
Search...

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiENOG410IE47 Eukaryota
ENOG4111F6B LUCA
GeneTreeiENSGT00950000183199
HOGENOMiHOG000168419
InParanoidiQ9Y2F5
OMAiGQISPLC
OrthoDBi265329at2759
PhylomeDBiQ9Y2F5
TreeFamiTF330760

Enzyme and pathway databases

ReactomeiR-HSA-6807505 RNA polymerase II transcribes snRNA genes
SIGNORiQ9Y2F5

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
ICE1 human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
23379

Protein Ontology

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PROi
PR:Q9Y2F5

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
Search...

Gene expression databases

BgeeiENSG00000164151 Expressed in 239 organ(s), highest expression level in female gonad
ExpressionAtlasiQ9Y2F5 baseline and differential
GenevisibleiQ9Y2F5 HS

Family and domain databases

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiICE1_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9Y2F5
Secondary accession number(s): Q68DE1
, Q6ZT40, Q7L587, Q7Z3A9, Q9NTH9
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 24, 2007
Last sequence update: May 18, 2010
Last modified: May 8, 2019
This is version 121 of the entry and version 5 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 5
    Human chromosome 5: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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