UniProtKB - Q9Y2E8 (SL9A8_HUMAN)
Protein
Sodium/hydrogen exchanger 8
Gene
SLC9A8
Organism
Homo sapiens (Human)
Status
Functioni
Involved in pH regulation to eliminate acids generated by active metabolism or to counter adverse environmental conditions. Major proton extruding system driven by the inward sodium ion chemical gradient. Plays an important role in signal transduction.1 Publication
GO - Molecular functioni
- potassium:proton antiporter activity Source: GO_Central
- sodium:proton antiporter activity Source: GO_Central
GO - Biological processi
- ion transport Source: Reactome
- potassium ion transmembrane transport Source: GO_Central
- regulation of intracellular pH Source: GO_Central
Keywordsi
Biological process | Antiport, Ion transport, Sodium transport, Transport |
Ligand | Sodium |
Enzyme and pathway databases
PathwayCommonsi | Q9Y2E8 |
Reactomei | R-HSA-425986, Sodium/Proton exchangers |
Protein family/group databases
TCDBi | 2.A.36.1.9, the monovalent cation:proton antiporter-1 (cpa1) family |
Names & Taxonomyi
Protein namesi | Recommended name: Sodium/hydrogen exchanger 8Alternative name(s): Na(+)/H(+) exchanger 8 Short name: NHE-8 Solute carrier family 9 member 8 |
Gene namesi | Name:SLC9A8 Synonyms:KIAA0939, NHE8 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
EuPathDBi | HostDB:ENSG00000197818.11 |
HGNCi | HGNC:20728, SLC9A8 |
MIMi | 612730, gene |
neXtProti | NX_Q9Y2E8 |
Subcellular locationi
Golgi apparatus
- Golgi apparatus membrane 1 Publication; Multi-pass membrane protein 1 Publication
Golgi apparatus
- Golgi apparatus Source: GO_Central
- Golgi membrane Source: Reactome
Other locations
- integral component of membrane Source: UniProtKB-KW
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Transmembranei | 60 – 80 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 84 – 104 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 123 – 143 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 156 – 176 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 191 – 211 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 264 – 284 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 311 – 331 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 354 – 374 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 379 – 399 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 417 – 437 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 451 – 471 | HelicalSequence analysisAdd BLAST | 21 |
Keywords - Cellular componenti
Golgi apparatus, MembranePathology & Biotechi
Organism-specific databases
DisGeNETi | 23315 |
OpenTargetsi | ENSG00000197818 |
PharmGKBi | PA134924114 |
Miscellaneous databases
Pharosi | Q9Y2E8, Tbio |
Polymorphism and mutation databases
BioMutai | SLC9A8 |
DMDMi | 254763448 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000052365 | 1 – 581 | Sodium/hydrogen exchanger 8Add BLAST | 581 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 510 | PhosphothreonineBy similarity | 1 | |
Modified residuei | 571 | PhosphoserineCombined sources | 1 | |
Modified residuei | 573 | PhosphoserineCombined sources | 1 |
Keywords - PTMi
PhosphoproteinProteomic databases
EPDi | Q9Y2E8 |
jPOSTi | Q9Y2E8 |
MassIVEi | Q9Y2E8 |
PaxDbi | Q9Y2E8 |
PeptideAtlasi | Q9Y2E8 |
PRIDEi | Q9Y2E8 |
ProteomicsDBi | 85751 [Q9Y2E8-1] 85752 [Q9Y2E8-2] |
PTM databases
iPTMneti | Q9Y2E8 |
PhosphoSitePlusi | Q9Y2E8 |
Expressioni
Tissue specificityi
Ubiquitous. Strongly expressed in skeletal muscle and kidney.1 Publication
Gene expression databases
Bgeei | ENSG00000197818, Expressed in blood and 184 other tissues |
Genevisiblei | Q9Y2E8, HS |
Organism-specific databases
HPAi | ENSG00000197818, Low tissue specificity |
Interactioni
Binary interactionsi
Q9Y2E8
With | #Exp. | IntAct |
---|---|---|
MEOX2 [Q6FHY5] | 3 | EBI-1222746,EBI-16439278 |
Protein-protein interaction databases
BioGRIDi | 116906, 21 interactors |
IntActi | Q9Y2E8, 2 interactors |
STRINGi | 9606.ENSP00000416418 |
Miscellaneous databases
RNActi | Q9Y2E8, protein |
Family & Domainsi
Sequence similaritiesi
Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family. [View classification]Curated
Keywords - Domaini
Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG1965, Eukaryota |
GeneTreei | ENSGT00940000157210 |
HOGENOMi | CLU_005912_11_0_1 |
InParanoidi | Q9Y2E8 |
OMAi | TSWRQFA |
OrthoDBi | 546232at2759 |
PhylomeDBi | Q9Y2E8 |
TreeFami | TF354313 |
Family and domain databases
InterProi | View protein in InterPro IPR006153, Cation/H_exchanger IPR018422, Cation/H_exchanger_CPA1 IPR004709, NaH_exchanger |
PANTHERi | PTHR10110, PTHR10110, 1 hit |
Pfami | View protein in Pfam PF00999, Na_H_Exchanger, 1 hit |
PRINTSi | PR01084, NAHEXCHNGR |
TIGRFAMsi | TIGR00840, b_cpa1, 1 hit |
s (2)i Sequence
Sequence statusi: Complete.
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basketIsoform 1 (identifier: Q9Y2E8-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MGEKMAEEER FPNTTHEGFN VTLHTTLVVT TKLVLPTPGK PILPVQTGEQ
60 70 80 90 100
AQQEEQSSGM TIFFSLLVLA ICIILVHLLI RYRLHFLPES VAVVSLGILM
110 120 130 140 150
GAVIKIIEFK KLANWKEEEM FRPNMFFLLL LPPIIFESGY SLHKGNFFQN
160 170 180 190 200
IGSITLFAVF GTAISAFVVG GGIYFLGQAD VISKLNMTDS FAFGSLISAV
210 220 230 240 250
DPVATIAIFN ALHVDPVLNM LVFGESILND AVSIVLTNTA EGLTRKNMSD
260 270 280 290 300
VSGWQTFLQA LDYFLKMFFG SAALGTLTGL ISALVLKHID LRKTPSLEFG
310 320 330 340 350
MMIIFAYLPY GLAEGISLSG IMAILFSGIV MSHYTHHNLS PVTQILMQQT
360 370 380 390 400
LRTVAFLCET CVFAFLGLSI FSFPHKFEIS FVIWCIVLVL FGRAVNIFPL
410 420 430 440 450
SYLLNFFRDH KITPKMMFIM WFSGLRGAIP YALSLHLDLE PMEKRQLIGT
460 470 480 490 500
TTIVIVLFTI LLLGGSTMPL IRLMDIEDAK AHRRNKKDVN LSKTEKMGNT
510 520 530 540 550
VESEHLSELT EEEYEAHYIR RQDLKGFVWL DAKYLNPFFT RRLTQEDLHH
560 570 580
GRIQMKTLTN KWYEEVRQGP SGSEDDEQEL L
Sequence cautioni
The sequence BAA76783 differs from that shown. Reason: Erroneous initiation.Curated
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 114 | N → D in BAC85475 (PubMed:14702039).Curated | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_037686 | 178 | Q → QGFFFVCVCVFVCFILQ in isoform 2. 1 Publication | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AB023156 mRNA Translation: BAA76783.2 Different initiation. AK131001 mRNA Translation: BAC85475.1 Different termination. AK300318 mRNA Translation: BAG62070.1 CR749638 mRNA Translation: CAH18432.1 AL162615 Genomic DNA No translation available. AL031685 Genomic DNA No translation available. CH471077 Genomic DNA Translation: EAW75649.1 BC112213 mRNA Translation: AAI12214.1 |
CCDSi | CCDS13421.1 [Q9Y2E8-1] CCDS58774.1 [Q9Y2E8-2] |
RefSeqi | NP_001247420.1, NM_001260491.1 [Q9Y2E8-2] NP_056081.1, NM_015266.2 [Q9Y2E8-1] |
Genome annotation databases
Ensembli | ENST00000361573; ENSP00000354966; ENSG00000197818 [Q9Y2E8-1] ENST00000417961; ENSP00000416418; ENSG00000197818 [Q9Y2E8-2] |
GeneIDi | 23315 |
KEGGi | hsa:23315 |
UCSCi | uc002xuv.3, human [Q9Y2E8-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AB023156 mRNA Translation: BAA76783.2 Different initiation. AK131001 mRNA Translation: BAC85475.1 Different termination. AK300318 mRNA Translation: BAG62070.1 CR749638 mRNA Translation: CAH18432.1 AL162615 Genomic DNA No translation available. AL031685 Genomic DNA No translation available. CH471077 Genomic DNA Translation: EAW75649.1 BC112213 mRNA Translation: AAI12214.1 |
CCDSi | CCDS13421.1 [Q9Y2E8-1] CCDS58774.1 [Q9Y2E8-2] |
RefSeqi | NP_001247420.1, NM_001260491.1 [Q9Y2E8-2] NP_056081.1, NM_015266.2 [Q9Y2E8-1] |
3D structure databases
SMRi | Q9Y2E8 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 116906, 21 interactors |
IntActi | Q9Y2E8, 2 interactors |
STRINGi | 9606.ENSP00000416418 |
Protein family/group databases
TCDBi | 2.A.36.1.9, the monovalent cation:proton antiporter-1 (cpa1) family |
PTM databases
iPTMneti | Q9Y2E8 |
PhosphoSitePlusi | Q9Y2E8 |
Polymorphism and mutation databases
BioMutai | SLC9A8 |
DMDMi | 254763448 |
Proteomic databases
EPDi | Q9Y2E8 |
jPOSTi | Q9Y2E8 |
MassIVEi | Q9Y2E8 |
PaxDbi | Q9Y2E8 |
PeptideAtlasi | Q9Y2E8 |
PRIDEi | Q9Y2E8 |
ProteomicsDBi | 85751 [Q9Y2E8-1] 85752 [Q9Y2E8-2] |
Protocols and materials databases
Antibodypediai | 28505, 155 antibodies |
Genome annotation databases
Ensembli | ENST00000361573; ENSP00000354966; ENSG00000197818 [Q9Y2E8-1] ENST00000417961; ENSP00000416418; ENSG00000197818 [Q9Y2E8-2] |
GeneIDi | 23315 |
KEGGi | hsa:23315 |
UCSCi | uc002xuv.3, human [Q9Y2E8-1] |
Organism-specific databases
CTDi | 23315 |
DisGeNETi | 23315 |
EuPathDBi | HostDB:ENSG00000197818.11 |
GeneCardsi | SLC9A8 |
HGNCi | HGNC:20728, SLC9A8 |
HPAi | ENSG00000197818, Low tissue specificity |
MIMi | 612730, gene |
neXtProti | NX_Q9Y2E8 |
OpenTargetsi | ENSG00000197818 |
PharmGKBi | PA134924114 |
HUGEi | Search... |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG1965, Eukaryota |
GeneTreei | ENSGT00940000157210 |
HOGENOMi | CLU_005912_11_0_1 |
InParanoidi | Q9Y2E8 |
OMAi | TSWRQFA |
OrthoDBi | 546232at2759 |
PhylomeDBi | Q9Y2E8 |
TreeFami | TF354313 |
Enzyme and pathway databases
PathwayCommonsi | Q9Y2E8 |
Reactomei | R-HSA-425986, Sodium/Proton exchangers |
Miscellaneous databases
BioGRID-ORCSi | 23315, 3 hits in 844 CRISPR screens |
ChiTaRSi | SLC9A8, human |
GeneWikii | SLC9A8 |
GenomeRNAii | 23315 |
Pharosi | Q9Y2E8, Tbio |
PROi | PR:Q9Y2E8 |
RNActi | Q9Y2E8, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000197818, Expressed in blood and 184 other tissues |
Genevisiblei | Q9Y2E8, HS |
Family and domain databases
InterProi | View protein in InterPro IPR006153, Cation/H_exchanger IPR018422, Cation/H_exchanger_CPA1 IPR004709, NaH_exchanger |
PANTHERi | PTHR10110, PTHR10110, 1 hit |
Pfami | View protein in Pfam PF00999, Na_H_Exchanger, 1 hit |
PRINTSi | PR01084, NAHEXCHNGR |
TIGRFAMsi | TIGR00840, b_cpa1, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | SL9A8_HUMAN | |
Accessioni | Q9Y2E8Primary (citable) accession number: Q9Y2E8 Secondary accession number(s): B4DTQ8 Q9Y507 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | March 1, 2004 |
Last sequence update: | July 28, 2009 | |
Last modified: | December 2, 2020 | |
This is version 165 of the entry and version 4 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families - Human chromosome 20
Human chromosome 20: entries, gene names and cross-references to MIM