Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

UniProtKB - Q9Y2E8 (SL9A8_HUMAN)

Entry version 165 (02 Dec 2020)
Sequence version 4 (28 Jul 2009)
Previous versions | rss
Add a publicationFeedback
Protein

Sodium/hydrogen exchanger 8

Gene

SLC9A8

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Involved in pH regulation to eliminate acids generated by active metabolism or to counter adverse environmental conditions. Major proton extruding system driven by the inward sodium ion chemical gradient. Plays an important role in signal transduction.1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processAntiport, Ion transport, Sodium transport, Transport
LigandSodium

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		Q9Y2E8

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-HSA-425986, Sodium/Proton exchangers

Protein family/group databases

Transport Classification Database

More...TCDBi		2.A.36.1.9, the monovalent cation:proton antiporter-1 (cpa1) family

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Sodium/hydrogen exchanger 8
Alternative name(s):
Na(+)/H(+) exchanger 8
Short name:
NHE-8
Solute carrier family 9 member 8
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:SLC9A8
Synonyms:KIAA0939, NHE8
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 20

Organism-specific databases

Eukaryotic Pathogen and Host Database Resources

More...EuPathDBi		HostDB:ENSG00000197818.11

Human Gene Nomenclature Database

More...HGNCi		HGNC:20728, SLC9A8

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		612730, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_Q9Y2E8

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei60 – 80HelicalSequence analysisAdd BLAST21
Transmembranei84 – 104HelicalSequence analysisAdd BLAST21
Transmembranei123 – 143HelicalSequence analysisAdd BLAST21
Transmembranei156 – 176HelicalSequence analysisAdd BLAST21
Transmembranei191 – 211HelicalSequence analysisAdd BLAST21
Transmembranei264 – 284HelicalSequence analysisAdd BLAST21
Transmembranei311 – 331HelicalSequence analysisAdd BLAST21
Transmembranei354 – 374HelicalSequence analysisAdd BLAST21
Transmembranei379 – 399HelicalSequence analysisAdd BLAST21
Transmembranei417 – 437HelicalSequence analysisAdd BLAST21
Transmembranei451 – 471HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Golgi apparatus, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...DisGeNETi		23315

Open Targets

More...OpenTargetsi		ENSG00000197818

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA134924114

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		Q9Y2E8, Tbio

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		SLC9A8

Domain mapping of disease mutations (DMDM)

More...DMDMi		254763448

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000523651 – 581Sodium/hydrogen exchanger 8Add BLAST581

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei510PhosphothreonineBy similarity1
Modified residuei571PhosphoserineCombined sources1
Modified residuei573PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		Q9Y2E8

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		Q9Y2E8

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		Q9Y2E8

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q9Y2E8

PeptideAtlas

More...PeptideAtlasi		Q9Y2E8

PRoteomics IDEntifications database

More...PRIDEi		Q9Y2E8

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		85751 [Q9Y2E8-1]
85752 [Q9Y2E8-2]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q9Y2E8

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q9Y2E8

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Ubiquitous. Strongly expressed in skeletal muscle and kidney.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000197818, Expressed in blood and 184 other tissues

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q9Y2E8, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000197818, Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		116906, 21 interactors

Protein interaction database and analysis system

More...IntActi		Q9Y2E8, 2 interactors

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000416418

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		Q9Y2E8, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q9Y2E8

Database of comparative protein structure models

More...ModBasei		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family. [View classification]Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG1965, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00940000157210

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_005912_11_0_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q9Y2E8

Identification of Orthologs from Complete Genome Data

More...OMAi		TSWRQFA

Database of Orthologous Groups

More...OrthoDBi		546232at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q9Y2E8

TreeFam database of animal gene trees

More...TreeFami		TF354313

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR006153, Cation/H_exchanger
IPR018422, Cation/H_exchanger_CPA1
IPR004709, NaH_exchanger

The PANTHER Classification System

More...PANTHERi		PTHR10110, PTHR10110, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF00999, Na_H_Exchanger, 1 hit

Protein Motif fingerprint database; a protein domain database

More...PRINTSi		PR01084, NAHEXCHNGR

TIGRFAMs; a protein family database

More...TIGRFAMsi		TIGR00840, b_cpa1, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
Isoform 1 (identifier: Q9Y2E8-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MGEKMAEEER FPNTTHEGFN VTLHTTLVVT TKLVLPTPGK PILPVQTGEQ 
        60         70         80         90        100
AQQEEQSSGM TIFFSLLVLA ICIILVHLLI RYRLHFLPES VAVVSLGILM 
       110        120        130        140        150
GAVIKIIEFK KLANWKEEEM FRPNMFFLLL LPPIIFESGY SLHKGNFFQN 
       160        170        180        190        200
IGSITLFAVF GTAISAFVVG GGIYFLGQAD VISKLNMTDS FAFGSLISAV 
       210        220        230        240        250
DPVATIAIFN ALHVDPVLNM LVFGESILND AVSIVLTNTA EGLTRKNMSD 
       260        270        280        290        300
VSGWQTFLQA LDYFLKMFFG SAALGTLTGL ISALVLKHID LRKTPSLEFG 
       310        320        330        340        350
MMIIFAYLPY GLAEGISLSG IMAILFSGIV MSHYTHHNLS PVTQILMQQT 
       360        370        380        390        400
LRTVAFLCET CVFAFLGLSI FSFPHKFEIS FVIWCIVLVL FGRAVNIFPL 
       410        420        430        440        450
SYLLNFFRDH KITPKMMFIM WFSGLRGAIP YALSLHLDLE PMEKRQLIGT 
       460        470        480        490        500
TTIVIVLFTI LLLGGSTMPL IRLMDIEDAK AHRRNKKDVN LSKTEKMGNT 
       510        520        530        540        550
VESEHLSELT EEEYEAHYIR RQDLKGFVWL DAKYLNPFFT RRLTQEDLHH 
       560        570        580 
GRIQMKTLTN KWYEEVRQGP SGSEDDEQEL L
Length:581
Mass (Da):65,422
Last modified:July 28, 2009 - v4
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i7508B62B74D584B1
GO
Isoform 2 (identifier: Q9Y2E8-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     178-178: Q → QGFFFVCVCVFVCFILQ

Show »
Length:597
Mass (Da):67,275
Checksum:iF82E64383B1E4192
GO

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence BAA76783 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti114N → D in BAC85475 (PubMed:14702039).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_037686178Q → QGFFFVCVCVFVCFILQ in isoform 2. 1 Publication1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AB023156 mRNA Translation: BAA76783.2 Different initiation.
AK131001 mRNA Translation: BAC85475.1 Different termination.
AK300318 mRNA Translation: BAG62070.1
CR749638 mRNA Translation: CAH18432.1
AL162615 Genomic DNA No translation available.
AL031685 Genomic DNA No translation available.
CH471077 Genomic DNA Translation: EAW75649.1
BC112213 mRNA Translation: AAI12214.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS13421.1 [Q9Y2E8-1]
CCDS58774.1 [Q9Y2E8-2]

NCBI Reference Sequences

More...RefSeqi		NP_001247420.1, NM_001260491.1 [Q9Y2E8-2]
NP_056081.1, NM_015266.2 [Q9Y2E8-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000361573; ENSP00000354966; ENSG00000197818 [Q9Y2E8-1]
ENST00000417961; ENSP00000416418; ENSG00000197818 [Q9Y2E8-2]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		23315

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:23315

UCSC genome browser

More...UCSCi		uc002xuv.3, human [Q9Y2E8-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB023156 mRNA Translation: BAA76783.2 Different initiation.
AK131001 mRNA Translation: BAC85475.1 Different termination.
AK300318 mRNA Translation: BAG62070.1
CR749638 mRNA Translation: CAH18432.1
AL162615 Genomic DNA No translation available.
AL031685 Genomic DNA No translation available.
CH471077 Genomic DNA Translation: EAW75649.1
BC112213 mRNA Translation: AAI12214.1
CCDSiCCDS13421.1 [Q9Y2E8-1]
CCDS58774.1 [Q9Y2E8-2]
RefSeqiNP_001247420.1, NM_001260491.1 [Q9Y2E8-2]
NP_056081.1, NM_015266.2 [Q9Y2E8-1]

3D structure databases

SMRiQ9Y2E8
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi116906, 21 interactors
IntActiQ9Y2E8, 2 interactors
STRINGi9606.ENSP00000416418

Protein family/group databases

TCDBi2.A.36.1.9, the monovalent cation:proton antiporter-1 (cpa1) family

PTM databases

iPTMnetiQ9Y2E8
PhosphoSitePlusiQ9Y2E8

Polymorphism and mutation databases

BioMutaiSLC9A8
DMDMi254763448

Proteomic databases

EPDiQ9Y2E8
jPOSTiQ9Y2E8
MassIVEiQ9Y2E8
PaxDbiQ9Y2E8
PeptideAtlasiQ9Y2E8
PRIDEiQ9Y2E8
ProteomicsDBi85751 [Q9Y2E8-1]
85752 [Q9Y2E8-2]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		28505, 155 antibodies

Genome annotation databases

EnsembliENST00000361573; ENSP00000354966; ENSG00000197818 [Q9Y2E8-1]
ENST00000417961; ENSP00000416418; ENSG00000197818 [Q9Y2E8-2]
GeneIDi23315
KEGGihsa:23315
UCSCiuc002xuv.3, human [Q9Y2E8-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		23315
DisGeNETi23315
EuPathDBiHostDB:ENSG00000197818.11

GeneCards: human genes, protein and diseases

More...GeneCardsi		SLC9A8
HGNCiHGNC:20728, SLC9A8
HPAiENSG00000197818, Low tissue specificity
MIMi612730, gene
neXtProtiNX_Q9Y2E8
OpenTargetsiENSG00000197818
PharmGKBiPA134924114

Human Unidentified Gene-Encoded large proteins database

More...HUGEi		Search...

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG1965, Eukaryota
GeneTreeiENSGT00940000157210
HOGENOMiCLU_005912_11_0_1
InParanoidiQ9Y2E8
OMAiTSWRQFA
OrthoDBi546232at2759
PhylomeDBiQ9Y2E8
TreeFamiTF354313

Enzyme and pathway databases

PathwayCommonsiQ9Y2E8
ReactomeiR-HSA-425986, Sodium/Proton exchangers

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		23315, 3 hits in 844 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		SLC9A8, human

The Gene Wiki collection of pages on human genes and proteins

More...GeneWikii		SLC9A8

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		23315
PharosiQ9Y2E8, Tbio

Protein Ontology

More...PROi		PR:Q9Y2E8
RNActiQ9Y2E8, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000197818, Expressed in blood and 184 other tissues
GenevisibleiQ9Y2E8, HS

Family and domain databases

InterProiView protein in InterPro
IPR006153, Cation/H_exchanger
IPR018422, Cation/H_exchanger_CPA1
IPR004709, NaH_exchanger
PANTHERiPTHR10110, PTHR10110, 1 hit
PfamiView protein in Pfam
PF00999, Na_H_Exchanger, 1 hit
PRINTSiPR01084, NAHEXCHNGR
TIGRFAMsiTIGR00840, b_cpa1, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiSL9A8_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9Y2E8
Secondary accession number(s): B4DTQ8
, Q2M1U9, Q68CZ8, Q9BX15, Q9Y507
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 1, 2004
Last sequence update: July 28, 2009
Last modified: December 2, 2020
This is version 165 of the entry and version 4 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families
  3. Human chromosome 20
    Human chromosome 20: entries, gene names and cross-references to MIM
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again