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Entry version 145 (12 Aug 2020)
Sequence version 2 (20 Mar 2007)
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Protein

E3 ubiquitin-protein ligase DTX4

Gene

DTX4

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Regulator of Notch signaling, a signaling pathway involved in cell-cell communications that regulates a broad spectrum of cell-fate determinations (By similarity). Functions as a ubiquitin ligase protein in vivo, mediating 'Lys48'-linked polyubiquitination and promoting degradation of TBK1, targeting to TBK1 requires interaction with NLRP4.By similarity1 Publication

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

  • S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.By similarity EC:2.3.2.27

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section describes the metabolic pathway(s) associated with a protein.<p><a href='/help/pathway' target='_top'>More...</a></p>Pathwayi: protein ubiquitination

This protein is involved in the pathway protein ubiquitination, which is part of Protein modification.
View all proteins of this organism that are known to be involved in the pathway protein ubiquitination and in Protein modification.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section specifies the position(s) and type(s) of zinc fingers within the protein.<p><a href='/help/zn_fing' target='_top'>More...</a></p>Zinc fingeri409 – 468RING-type; atypicalPROSITE-ProRule annotationAdd BLAST60

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionTransferase
Biological processNotch signaling pathway, Ubl conjugation pathway
LigandMetal-binding, Zinc

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...
PathwayCommonsi
Q9Y2E6

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-1606341, IRF3 mediated activation of type 1 IFN
R-HSA-2122948, Activated NOTCH1 Transmits Signal to the Nucleus
R-HSA-3134975, Regulation of innate immune responses to cytosolic DNA
R-HSA-3270619, IRF3-mediated induction of type I IFN

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...
SignaLinki
Q9Y2E6

SIGNOR Signaling Network Open Resource

More...
SIGNORi
Q9Y2E6

UniPathway: a resource for the exploration and annotation of metabolic pathways

More...
UniPathwayi
UPA00143

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
E3 ubiquitin-protein ligase DTX4 (EC:2.3.2.27By similarity)
Alternative name(s):
Protein deltex-4
Short name:
Deltex4
RING finger protein 155
RING-type E3 ubiquitin transferase DTX4Curated
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:DTX4
Synonyms:KIAA0937, RNF155
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 11

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000110042.7

Human Gene Nomenclature Database

More...
HGNCi
HGNC:29151, DTX4

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
616110, gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q9Y2E6

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
23220

Open Targets

More...
OpenTargetsi
ENSG00000110042

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA134930720

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q9Y2E6, Tbio

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
DTX4

Domain mapping of disease mutations (DMDM)

More...
DMDMi
134034097

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002805551 – 619E3 ubiquitin-protein ligase DTX4Add BLAST619

Proteomic databases

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
Q9Y2E6

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q9Y2E6

PeptideAtlas

More...
PeptideAtlasi
Q9Y2E6

PRoteomics IDEntifications database

More...
PRIDEi
Q9Y2E6

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
85749 [Q9Y2E6-1]
85750 [Q9Y2E6-2]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q9Y2E6

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q9Y2E6

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000110042, Expressed in nasal cavity epithelium and 227 other tissues

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q9Y2E6, HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
ENSG00000110042, Tissue enhanced (brain)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with NLRP4.

1 Publication

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
116827, 9 interactors

Protein interaction database and analysis system

More...
IntActi
Q9Y2E6, 2 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000227451

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q9Y2E6, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q9Y2E6

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini1 – 78WWE 1PROSITE-ProRule annotationAdd BLAST78
Domaini79 – 155WWE 2PROSITE-ProRule annotationAdd BLAST77

<p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The WWE domains are thought to mediate some protein-protein interaction, and are frequently found in ubiquitin ligases.By similarity

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the Deltex family.Curated

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri409 – 468RING-type; atypicalPROSITE-ProRule annotationAdd BLAST60

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG502QQ9M, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000157122

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_030422_4_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q9Y2E6

KEGG Orthology (KO)

More...
KOi
K06058

Identification of Orthologs from Complete Genome Data

More...
OMAi
DFATMGQ

Database of Orthologous Groups

More...
OrthoDBi
600021at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q9Y2E6

TreeFam database of animal gene trees

More...
TreeFami
TF325526

Family and domain databases

Conserved Domains Database

More...
CDDi
cd09633, Deltex_C, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
3.30.390.130, 1 hit
3.30.40.10, 1 hit
3.30.720.50, 2 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR039396, Deltex_C
IPR039399, Deltex_C_sf
IPR039398, Deltex_fam
IPR004170, WWE-dom
IPR018123, WWE-dom_subgr
IPR037197, WWE_dom_sf
IPR018957, Znf_C3HC4_RING-type
IPR001841, Znf_RING
IPR013083, Znf_RING/FYVE/PHD

The PANTHER Classification System

More...
PANTHERi
PTHR12622, PTHR12622, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF18102, DTC, 1 hit
PF02825, WWE, 2 hits
PF00097, zf-C3HC4, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00184, RING, 1 hit
SM00678, WWE, 2 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF117839, SSF117839, 2 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50918, WWE, 2 hits
PS50089, ZF_RING_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
Isoform 1 (identifier: Q9Y2E6-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MLLASAVVVW EWLNEHGRWR PYSPAVSHHI EAVVRAGPRA GGSVVLGQVD
60 70 80 90 100
SRLAPYIIDL QSMNQFRQDT GTLRPVRRNY YDPSSAPGKG VVWEWENDNG
110 120 130 140 150
SWTPYDMEVG ITIQHAYEKQ HPWIDLTSIG FSYVIDFNTM GQINRQTQRQ
160 170 180 190 200
RRVRRRLDLI YPMVTGTLPK AQSWPVSPGP ATSPPMSPCS CPQCVLVMSV
210 220 230 240 250
KAAVVNGSTG PLQLPVTRKN MPPPGVVKLP PLPGSGAKPL DSTGTIRGPL
260 270 280 290 300
KTAPSQVIRR QASSMPTGTT MGSPASPPGP NSKTGRVALA TLNRTNLQRL
310 320 330 340 350
AIAQSRVLIA SGVPTVPVKN LNGSSPVNPA LAGITGILMS AAGLPVCLTR
360 370 380 390 400
PPKLVLHPPP VSKSEIKSIP GVSNTSRKTT KKQAKKGKTP EEVLKKYLQK
410 420 430 440 450
VRHPPDEDCT ICMERLTAPS GYKGPQPTVK PDLVGKLSRC GHVYHIYCLV
460 470 480 490 500
AMYNNGNKDG SLQCPTCKTI YGVKTGTQPP GKMEYHLIPH SLPGHPDCKT
510 520 530 540 550
IRIIYSIPPG IQGPEHPNPG KSFSARGFPR HCYLPDSEKG RKVLKLLLVA
560 570 580 590 600
WDRRLIFAIG TSSTTGESDT VIWNEVHHKT EFGSNLTGHG YPDANYLDNV
610
LAELAAQGIS EDSTAQEKD
Length:619
Mass (Da):67,258
Last modified:March 20, 2007 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i5C851845B42630BD
GO
Isoform 2 (identifier: Q9Y2E6-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-106: Missing.

Show »
Length:513
Mass (Da):55,284
Checksum:iCBC72BC1D20CDD5C
GO

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence BAA76781 differs from that shown. Reason: Erroneous initiation. Extended N-terminus.Curated

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0237841 – 106Missing in isoform 2. 1 PublicationAdd BLAST106

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AB023154 mRNA Translation: BAA76781.1 Different initiation.
BC119011 mRNA Translation: AAI19012.1
BC122861 mRNA Translation: AAI22862.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS44612.1 [Q9Y2E6-1]
CCDS76408.1 [Q9Y2E6-2]

NCBI Reference Sequences

More...
RefSeqi
NP_001287656.1, NM_001300727.1 [Q9Y2E6-2]
NP_055992.1, NM_015177.1 [Q9Y2E6-1]
XP_006718546.1, XM_006718483.3 [Q9Y2E6-2]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000227451; ENSP00000227451; ENSG00000110042 [Q9Y2E6-1]
ENST00000532982; ENSP00000434055; ENSG00000110042 [Q9Y2E6-2]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
23220

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:23220

UCSC genome browser

More...
UCSCi
uc001nnr.3, human [Q9Y2E6-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB023154 mRNA Translation: BAA76781.1 Different initiation.
BC119011 mRNA Translation: AAI19012.1
BC122861 mRNA Translation: AAI22862.1
CCDSiCCDS44612.1 [Q9Y2E6-1]
CCDS76408.1 [Q9Y2E6-2]
RefSeqiNP_001287656.1, NM_001300727.1 [Q9Y2E6-2]
NP_055992.1, NM_015177.1 [Q9Y2E6-1]
XP_006718546.1, XM_006718483.3 [Q9Y2E6-2]

3D structure databases

SMRiQ9Y2E6
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi116827, 9 interactors
IntActiQ9Y2E6, 2 interactors
STRINGi9606.ENSP00000227451

PTM databases

iPTMnetiQ9Y2E6
PhosphoSitePlusiQ9Y2E6

Polymorphism and mutation databases

BioMutaiDTX4
DMDMi134034097

Proteomic databases

MassIVEiQ9Y2E6
PaxDbiQ9Y2E6
PeptideAtlasiQ9Y2E6
PRIDEiQ9Y2E6
ProteomicsDBi85749 [Q9Y2E6-1]
85750 [Q9Y2E6-2]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...
Antibodypediai
52744, 126 antibodies

Genome annotation databases

EnsembliENST00000227451; ENSP00000227451; ENSG00000110042 [Q9Y2E6-1]
ENST00000532982; ENSP00000434055; ENSG00000110042 [Q9Y2E6-2]
GeneIDi23220
KEGGihsa:23220
UCSCiuc001nnr.3, human [Q9Y2E6-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
23220
DisGeNETi23220
EuPathDBiHostDB:ENSG00000110042.7

GeneCards: human genes, protein and diseases

More...
GeneCardsi
DTX4
HGNCiHGNC:29151, DTX4
HPAiENSG00000110042, Tissue enhanced (brain)
MIMi616110, gene
neXtProtiNX_Q9Y2E6
OpenTargetsiENSG00000110042
PharmGKBiPA134930720

Human Unidentified Gene-Encoded large proteins database

More...
HUGEi
Search...

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiENOG502QQ9M, Eukaryota
GeneTreeiENSGT00940000157122
HOGENOMiCLU_030422_4_0_1
InParanoidiQ9Y2E6
KOiK06058
OMAiDFATMGQ
OrthoDBi600021at2759
PhylomeDBiQ9Y2E6
TreeFamiTF325526

Enzyme and pathway databases

UniPathwayiUPA00143
PathwayCommonsiQ9Y2E6
ReactomeiR-HSA-1606341, IRF3 mediated activation of type 1 IFN
R-HSA-2122948, Activated NOTCH1 Transmits Signal to the Nucleus
R-HSA-3134975, Regulation of innate immune responses to cytosolic DNA
R-HSA-3270619, IRF3-mediated induction of type I IFN
SignaLinkiQ9Y2E6
SIGNORiQ9Y2E6

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

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BioGRID-ORCSi
23220, 7 hits in 873 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
DTX4, human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
23220
PharosiQ9Y2E6, Tbio

Protein Ontology

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PROi
PR:Q9Y2E6
RNActiQ9Y2E6, protein

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
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Gene expression databases

BgeeiENSG00000110042, Expressed in nasal cavity epithelium and 227 other tissues
GenevisibleiQ9Y2E6, HS

Family and domain databases

CDDicd09633, Deltex_C, 1 hit
Gene3Di3.30.390.130, 1 hit
3.30.40.10, 1 hit
3.30.720.50, 2 hits
InterProiView protein in InterPro
IPR039396, Deltex_C
IPR039399, Deltex_C_sf
IPR039398, Deltex_fam
IPR004170, WWE-dom
IPR018123, WWE-dom_subgr
IPR037197, WWE_dom_sf
IPR018957, Znf_C3HC4_RING-type
IPR001841, Znf_RING
IPR013083, Znf_RING/FYVE/PHD
PANTHERiPTHR12622, PTHR12622, 1 hit
PfamiView protein in Pfam
PF18102, DTC, 1 hit
PF02825, WWE, 2 hits
PF00097, zf-C3HC4, 1 hit
SMARTiView protein in SMART
SM00184, RING, 1 hit
SM00678, WWE, 2 hits
SUPFAMiSSF117839, SSF117839, 2 hits
PROSITEiView protein in PROSITE
PS50918, WWE, 2 hits
PS50089, ZF_RING_2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiDTX4_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9Y2E6
Secondary accession number(s): Q0VF38
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 20, 2007
Last sequence update: March 20, 2007
Last modified: August 12, 2020
This is version 145 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  4. SIMILARITY comments
    Index of protein domains and families
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