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Entry version 162 (08 May 2019)
Sequence version 4 (18 May 2010)
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Protein

Epididymis-specific alpha-mannosidase

Gene

MAN2B2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

  • Hydrolysis of terminal, non-reducing alpha-D-mannose residues in alpha-D-mannosides. EC:3.2.1.24

<p>This subsection of the ‘Function’ section provides information relevant to cofactors. A cofactor is any non-protein substance required for a protein to be catalytically active. Some cofactors are inorganic, such as the metal atoms zinc, iron, and copper in various oxidation states. Others, such as most vitamins, are organic.<p><a href='/help/cofactor' target='_top'>More...</a></p>Cofactori

Zn2+By similarityNote: Binds 1 zinc ion per subunit.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Function’ section indicates at which position the protein binds a given metal ion. The nature of the metal is indicated in the ‘Description’ field.<p><a href='/help/metal' target='_top'>More...</a></p>Metal bindingi36ZincBy similarity1
Metal bindingi38ZincBy similarity1
<p>This subsection of the ‘Function’ section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei151NucleophileBy similarity1
Metal bindingi151ZincBy similarity1
Metal bindingi420ZincBy similarity1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • alpha-mannosidase activity Source: GO_Central
  • carbohydrate binding Source: InterPro
  • metal ion binding Source: UniProtKB-KW

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionGlycosidase, Hydrolase
LigandMetal-binding, Zinc

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-8853383 Lysosomal oligosaccharide catabolism

Protein family/group databases

Carbohydrate-Active enZymes

More...
CAZyi
GH38 Glycoside Hydrolase Family 38

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Epididymis-specific alpha-mannosidase (EC:3.2.1.24)
Alternative name(s):
Mannosidase alpha class 2B member 2
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:MAN2B2
Synonyms:KIAA0935
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 4

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:29623 MAN2B2

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q9Y2E5

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Open Targets

More...
OpenTargetsi
ENSG00000013288

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA128394625

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...
ChEMBLi
CHEMBL2682

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
MAN2B2

Domain mapping of disease mutations (DMDM)

More...
DMDMi
296439484

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 23Sequence analysisAdd BLAST23
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000001207724 – 1009Epididymis-specific alpha-mannosidaseAdd BLAST986

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi226N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi249N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi294N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi336N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi516N-linked (GlcNAc...) asparagine1 Publication1
Glycosylationi608N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi670N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi675N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi748N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi808N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi812N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi890N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q9Y2E5

jPOST - Japan Proteome Standard Repository/Database

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jPOSTi
Q9Y2E5

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q9Y2E5

PeptideAtlas

More...
PeptideAtlasi
Q9Y2E5

PRoteomics IDEntifications database

More...
PRIDEi
Q9Y2E5

ProteomicsDB human proteome resource

More...
ProteomicsDBi
85747
85748 [Q9Y2E5-2]

PTM databases

GlyConnect protein glycosylation platform

More...
GlyConnecti
1216

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q9Y2E5

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q9Y2E5

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000013288 Expressed in 229 organ(s), highest expression level in tendon

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
Q9Y2E5 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
Q9Y2E5 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA037005

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
116912, 9 interactors

Protein interaction database and analysis system

More...
IntActi
Q9Y2E5, 9 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000285599

Chemistry databases

BindingDB database of measured binding affinities

More...
BindingDBi
Q9Y2E5

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the glycosyl hydrolase 38 family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1959 Eukaryota
ENOG410XQMZ LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00950000182799

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000113450

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q9Y2E5

KEGG Orthology (KO)

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KOi
K12312

Identification of Orthologs from Complete Genome Data

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OMAi
VARNYYP

Database of Orthologous Groups

More...
OrthoDBi
201312at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q9Y2E5

TreeFam database of animal gene trees

More...
TreeFami
TF332447

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.20.1270.50, 2 hits
2.60.40.1180, 1 hit
3.20.110.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR011013 Gal_mutarotase_sf_dom
IPR041147 GH38_C
IPR011330 Glyco_hydro/deAcase_b/a-brl
IPR011682 Glyco_hydro_38_C
IPR015341 Glyco_hydro_38_cen
IPR037094 Glyco_hydro_38_cen_sf
IPR000602 Glyco_hydro_38_N
IPR027291 Glyco_hydro_38_N_sf
IPR028995 Glyco_hydro_57/38_cen_sf
IPR013780 Glyco_hydro_b

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF09261 Alpha-mann_mid, 1 hit
PF17677 Glyco_hydro38C2, 1 hit
PF07748 Glyco_hydro_38C, 1 hit
PF01074 Glyco_hydro_38N, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00872 Alpha-mann_mid, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF74650 SSF74650, 1 hit
SSF88688 SSF88688, 1 hit
SSF88713 SSF88713, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q9Y2E5-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MGQLCWLPLL APLLLLRPPG VQSAGPIRAF VVPHSHMDVG WVYTVQESMR
60 70 80 90 100
AYAANVYTSV VEELARGQQR RFIAVEQEFF RLWWDGVASD QQKYQVRQLL
110 120 130 140 150
EEGRLEFVIG GQVMHDEAVT HLDDQILQLT EGHGFLYETF GIRPQFSWHV
160 170 180 190 200
DPFGASATTP TLFALAGFNA HLGSRIDYDL KAAMQEARGL QFVWRGSPSL
210 220 230 240 250
SERQEIFTHI MDQYSYCTPS HIPFSNRSGF YWNGVAVFPK PPQDGVYPNM
260 270 280 290 300
SEPVTPANIN LYAEALVANV KQRAAWFRTP HVLWPWGCDK QFFNASVQFA
310 320 330 340 350
NMDPLLDHIN SHAAELGVSV QYATLGDYFR ALHALNVTWR VRDHHDFLPY
360 370 380 390 400
STEPFQAWTG FYTSRSSLKG LARRASALLY AGESMFTRYL WPAPRGHLDP
410 420 430 440 450
TWALQQLQQL RWAVSEVQHH DAITGTESPK VRDMYATHLA SGMLGMRKLM
460 470 480 490 500
ASIVLDELQP QAPMAASSDA GPAGHFASVY NPLAWTVTTI VTLTVGFPGV
510 520 530 540 550
RVTDEAGHPV PSQIQNSTET PSAYDLLILT TIPGLSYRHY NIRPTAGAQE
560 570 580 590 600
GTQEPAATVA STLQFGRRLR RRTSHAGRYL VPVANDCYIV LLDQDTNLMH
610 620 630 640 650
SIWERQSNRT VRVTQEFLEY HVNGDVKQGP ISDNYLFTPG KAAVPAWEAV
660 670 680 690 700
EMEIVAGQLV TEIRQYFYRN MTAQNYTYAI RSRLTHVPQG HDGELLCHRI
710 720 730 740 750
EQEYQAGPLE LNREAVLRTS TNLNSQQVIY SDNNGYQMQR RPYVSYVNNS
760 770 780 790 800
IARNYYPMVQ SAFMEDGKSR LVLLSERAHG ISSQGNGQVE VMLHRRLWNN
810 820 830 840 850
FDWDLGYNLT LNDTSVVHPV LWLLLGSWSL TTALRQRSAL ALQHRPVVLF
860 870 880 890 900
GDLAGTAPKL PGPQQQEAVT LPPNLHLQIL SIPGWRYSSN HTEHSQNLRK
910 920 930 940 950
GHRGEAQADL RRVLLRLYHL YEVGEDPVLS QPVTVNLEAV LQALGSVVAV
960 970 980 990 1000
EERSLTGTWD LSMLHRWSWR TGPGRHRGDT TSPSRPPGGP IITVHPKEIR

TFFIHFQQQ
Length:1,009
Mass (Da):113,979
Last modified:May 18, 2010 - v4
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i21BB879400E0F387
GO
Isoform 2 (identifier: Q9Y2E5-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     939-1009: AVLQALGSVV...RTFFIHFQQQ → VNFPTPIQTISQGSKP

Note: No experimental confirmation available.
Show »
Length:954
Mass (Da):107,704
Checksum:i9EF3191B5AA34B4F
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E9PCD7E9PCD7_HUMAN
Alpha-mannosidase
MAN2B2
958Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0YA68H0YA68_HUMAN
Alpha-mannosidase
MAN2B2
953Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti79F → S in CAD89971 (PubMed:17974005).Curated1
Sequence conflicti938E → Q in CAD89971 (PubMed:17974005).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_025328243Q → P2 PublicationsCorresponds to variant dbSNP:rs2301796Ensembl.1
Natural variantiVAR_025329320V → M1 PublicationCorresponds to variant dbSNP:rs2301795Ensembl.1
Natural variantiVAR_055840365R → C. Corresponds to variant dbSNP:rs6858328Ensembl.1
Natural variantiVAR_025330446M → V2 PublicationsCorresponds to variant dbSNP:rs2301790Ensembl.1
Natural variantiVAR_025331541N → S2 PublicationsCorresponds to variant dbSNP:rs2301788Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_013816939 – 1009AVLQA…HFQQQ → VNFPTPIQTISQGSKP in isoform 2. 1 PublicationAdd BLAST71

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AL833071 mRNA Translation: CAD89971.1
AC004480 Genomic DNA No translation available.
BC033307 mRNA Translation: AAH33307.1
AB023152 mRNA Translation: BAA76779.2

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS33951.1 [Q9Y2E5-1]

NCBI Reference Sequences

More...
RefSeqi
NP_001278967.1, NM_001292038.1
NP_056089.1, NM_015274.2 [Q9Y2E5-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000285599; ENSP00000285599; ENSG00000013288 [Q9Y2E5-1]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
23324

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:23324

UCSC genome browser

More...
UCSCi
uc003gjf.2 human [Q9Y2E5-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL833071 mRNA Translation: CAD89971.1
AC004480 Genomic DNA No translation available.
BC033307 mRNA Translation: AAH33307.1
AB023152 mRNA Translation: BAA76779.2
CCDSiCCDS33951.1 [Q9Y2E5-1]
RefSeqiNP_001278967.1, NM_001292038.1
NP_056089.1, NM_015274.2 [Q9Y2E5-1]

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

BioGridi116912, 9 interactors
IntActiQ9Y2E5, 9 interactors
STRINGi9606.ENSP00000285599

Chemistry databases

BindingDBiQ9Y2E5
ChEMBLiCHEMBL2682

Protein family/group databases

CAZyiGH38 Glycoside Hydrolase Family 38

PTM databases

GlyConnecti1216
iPTMnetiQ9Y2E5
PhosphoSitePlusiQ9Y2E5

Polymorphism and mutation databases

BioMutaiMAN2B2
DMDMi296439484

Proteomic databases

EPDiQ9Y2E5
jPOSTiQ9Y2E5
PaxDbiQ9Y2E5
PeptideAtlasiQ9Y2E5
PRIDEiQ9Y2E5
ProteomicsDBi85747
85748 [Q9Y2E5-2]

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000285599; ENSP00000285599; ENSG00000013288 [Q9Y2E5-1]
GeneIDi23324
KEGGihsa:23324
UCSCiuc003gjf.2 human [Q9Y2E5-1]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
23324

GeneCards: human genes, protein and diseases

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GeneCardsi
MAN2B2

H-Invitational Database, human transcriptome db

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H-InvDBi
HIX0200620
HGNCiHGNC:29623 MAN2B2
HPAiHPA037005
neXtProtiNX_Q9Y2E5
OpenTargetsiENSG00000013288
PharmGKBiPA128394625

Human Unidentified Gene-Encoded large proteins database

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HUGEi
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GenAtlas: human gene database

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GenAtlasi
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Phylogenomic databases

eggNOGiKOG1959 Eukaryota
ENOG410XQMZ LUCA
GeneTreeiENSGT00950000182799
HOGENOMiHOG000113450
InParanoidiQ9Y2E5
KOiK12312
OMAiVARNYYP
OrthoDBi201312at2759
PhylomeDBiQ9Y2E5
TreeFamiTF332447

Enzyme and pathway databases

ReactomeiR-HSA-8853383 Lysosomal oligosaccharide catabolism

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
MAN2B2 human

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
MAN2B2

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
23324

Protein Ontology

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PROi
PR:Q9Y2E5

Gene expression databases

BgeeiENSG00000013288 Expressed in 229 organ(s), highest expression level in tendon
ExpressionAtlasiQ9Y2E5 baseline and differential
GenevisibleiQ9Y2E5 HS

Family and domain databases

Gene3Di1.20.1270.50, 2 hits
2.60.40.1180, 1 hit
3.20.110.10, 1 hit
InterProiView protein in InterPro
IPR011013 Gal_mutarotase_sf_dom
IPR041147 GH38_C
IPR011330 Glyco_hydro/deAcase_b/a-brl
IPR011682 Glyco_hydro_38_C
IPR015341 Glyco_hydro_38_cen
IPR037094 Glyco_hydro_38_cen_sf
IPR000602 Glyco_hydro_38_N
IPR027291 Glyco_hydro_38_N_sf
IPR028995 Glyco_hydro_57/38_cen_sf
IPR013780 Glyco_hydro_b
PfamiView protein in Pfam
PF09261 Alpha-mann_mid, 1 hit
PF17677 Glyco_hydro38C2, 1 hit
PF07748 Glyco_hydro_38C, 1 hit
PF01074 Glyco_hydro_38N, 1 hit
SMARTiView protein in SMART
SM00872 Alpha-mann_mid, 1 hit
SUPFAMiSSF74650 SSF74650, 1 hit
SSF88688 SSF88688, 1 hit
SSF88713 SSF88713, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiMA2B2_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9Y2E5
Secondary accession number(s): Q66MP2, Q86T67
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 16, 2001
Last sequence update: May 18, 2010
Last modified: May 8, 2019
This is version 162 of the entry and version 4 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 4
    Human chromosome 4: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. Glycosyl hydrolases
    Classification of glycosyl hydrolase families and list of entries
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