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Protein

Zinc finger protein 652

Gene

ZNF652

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Functions as a transcriptional repressor.1 Publication

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri245 – 268C2H2-type 1PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri272 – 294C2H2-type 2; degeneratePROSITE-ProRule annotationAdd BLAST23
Zinc fingeri299 – 322C2H2-type 3PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri329 – 351C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri357 – 379C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri385 – 407C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri413 – 435C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri441 – 463C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri469 – 492C2H2-type 9; degeneratePROSITE-ProRule annotationAdd BLAST24

GO - Molecular functioni

GO - Biological processi

  • cellular response to DNA damage stimulus Source: GO_Central

Keywordsi

Molecular functionDNA-binding, Repressor
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

Enzyme and pathway databases

SIGNORiQ9Y2D9

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein 652
Gene namesi
Name:ZNF652
Synonyms:KIAA0924
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 17

Organism-specific databases

EuPathDBiHostDB:ENSG00000198740.8
HGNCiHGNC:29147 ZNF652
MIMi613907 gene
neXtProtiNX_Q9Y2D9

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi22834
OpenTargetsiENSG00000198740
PharmGKBiPA134896615

Polymorphism and mutation databases

BioMutaiZNF652
DMDMi134035373

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002804281 – 606Zinc finger protein 652Add BLAST606

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei57PhosphoserineCombined sources1
Modified residuei100PhosphoserineBy similarity1
Modified residuei103PhosphothreonineBy similarity1
Modified residuei197PhosphoserineCombined sources1
Modified residuei204PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ9Y2D9
MaxQBiQ9Y2D9
PaxDbiQ9Y2D9
PeptideAtlasiQ9Y2D9
PRIDEiQ9Y2D9
ProteomicsDBi85745

PTM databases

iPTMnetiQ9Y2D9
PhosphoSitePlusiQ9Y2D9

Expressioni

Tissue specificityi

Widely expressed with higher expression in breast, prostate, vulva and pancreas.1 Publication

Gene expression databases

BgeeiENSG00000198740 Expressed in 226 organ(s), highest expression level in globus pallidus
CleanExiHS_ZNF652
ExpressionAtlasiQ9Y2D9 baseline and differential
GenevisibleiQ9Y2D9 HS

Organism-specific databases

HPAiHPA044408

Interactioni

Subunit structurei

Interacts with CBFA2T3.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
CBFA2T3O750812EBI-1190229,EBI-1190217

Protein-protein interaction databases

IntActiQ9Y2D9, 4 interactors
STRINGi9606.ENSP00000354686

Structurei

3D structure databases

ProteinModelPortaliQ9Y2D9
SMRiQ9Y2D9
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni498 – 606Mediates interaction with CBFA2T31 PublicationAdd BLAST109

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi74 – 183Glu-richAdd BLAST110
Compositional biasi497 – 574Pro-richAdd BLAST78

Sequence similaritiesi

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri245 – 268C2H2-type 1PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri272 – 294C2H2-type 2; degeneratePROSITE-ProRule annotationAdd BLAST23
Zinc fingeri299 – 322C2H2-type 3PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri329 – 351C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri357 – 379C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri385 – 407C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri413 – 435C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri441 – 463C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri469 – 492C2H2-type 9; degeneratePROSITE-ProRule annotationAdd BLAST24

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721 Eukaryota
COG5048 LUCA
GeneTreeiENSGT00440000037877
HOGENOMiHOG000231037
HOVERGENiHBG064823
InParanoidiQ9Y2D9
OMAiGQSEDSF
OrthoDBiEOG091G055W
PhylomeDBiQ9Y2D9
TreeFamiTF332655

Family and domain databases

InterProiView protein in InterPro
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type
PfamiView protein in Pfam
PF00096 zf-C2H2, 5 hits
SMARTiView protein in SMART
SM00355 ZnF_C2H2, 9 hits
SUPFAMiSSF57667 SSF57667, 5 hits
PROSITEiView protein in PROSITE
PS00028 ZINC_FINGER_C2H2_1, 7 hits
PS50157 ZINC_FINGER_C2H2_2, 9 hits

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

Q9Y2D9-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSHTASSCQE LVENCAVHVA GMAQEDSRRG QVPSSFYHGA NQELDLSTKV
60 70 80 90 100
YKRESGSPYS VLVDTKMSKP HLHETEEQPY FRETRAVSDV HAVKEDRENS
110 120 130 140 150
DDTEEEEEEV SYKREQIIVE VNLNNQTLNV SKGEKGVSSQ SKETPVLKTS
160 170 180 190 200
SEEEEEESEE EATDDSNDYG ENEKQKKKEK IVEKVSVTQR RTRRAASVAA
210 220 230 240 250
ATTSPTPRTT RGRRKSVEPP KRKKRATKEP KAPVQKAKCE EKETLTCEKC
260 270 280 290 300
PRVFNTRWYL EKHMNVTHRR MQICDKCGKK FVLESELSLH QQTDCEKNIQ
310 320 330 340 350
CVSCNKSFKK LWSLHEHIKI VHGYAEKKFS CEICEKKFYT MAHVRKHMVA
360 370 380 390 400
HTKDMPFTCE TCGKSFKRSM SLKVHSLQHS GEKPFRCENC DERFQYKYQL
410 420 430 440 450
RSHMSIHIGH KQFMCQWCGK DFNMKQYFDE HMKTHTGEKP FICEICGKSF
460 470 480 490 500
TSRPNMKRHR RTHTGEKPYP CDVCGQRFRF SNMLKAHKEK CFRVTSPVNV
510 520 530 540 550
PPAVQIPLTT SPATPVPSVV NTATTPTPPI NMNPVSTLPP RPIPHPFSHL
560 570 580 590 600
HIHPHPHHPH HLPIPPVPHL PPPPALFKSE PLNHRGQSED NFLRHLAEKN

SSAQHH
Length:606
Mass (Da):69,744
Last modified:March 20, 2007 - v3
Checksum:iC066D10E179985CC
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
D6RF85D6RF85_HUMAN
Zinc finger protein 652, isoform CR...
ZNF652 hCG_27356
426Annotation score:

Sequence cautioni

The sequence BAA76768 differs from that shown. Reason: Erroneous initiation.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB023141 mRNA Translation: BAA76768.2 Different initiation.
CR933680 mRNA Translation: CAI45974.1
CH471109 Genomic DNA Translation: EAW94682.1
BC139779 mRNA Translation: AAI39780.1
BC152440 mRNA Translation: AAI52441.1
CCDSiCCDS32677.1
RefSeqiNP_001138837.1, NM_001145365.1
NP_055712.1, NM_014897.2
UniGeneiHs.463375
Hs.712948

Genome annotation databases

EnsembliENST00000362063; ENSP00000354686; ENSG00000198740
ENST00000430262; ENSP00000416305; ENSG00000198740
GeneIDi22834
KEGGihsa:22834
UCSCiuc002iov.5 human

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB023141 mRNA Translation: BAA76768.2 Different initiation.
CR933680 mRNA Translation: CAI45974.1
CH471109 Genomic DNA Translation: EAW94682.1
BC139779 mRNA Translation: AAI39780.1
BC152440 mRNA Translation: AAI52441.1
CCDSiCCDS32677.1
RefSeqiNP_001138837.1, NM_001145365.1
NP_055712.1, NM_014897.2
UniGeneiHs.463375
Hs.712948

3D structure databases

ProteinModelPortaliQ9Y2D9
SMRiQ9Y2D9
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ9Y2D9, 4 interactors
STRINGi9606.ENSP00000354686

PTM databases

iPTMnetiQ9Y2D9
PhosphoSitePlusiQ9Y2D9

Polymorphism and mutation databases

BioMutaiZNF652
DMDMi134035373

Proteomic databases

EPDiQ9Y2D9
MaxQBiQ9Y2D9
PaxDbiQ9Y2D9
PeptideAtlasiQ9Y2D9
PRIDEiQ9Y2D9
ProteomicsDBi85745

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000362063; ENSP00000354686; ENSG00000198740
ENST00000430262; ENSP00000416305; ENSG00000198740
GeneIDi22834
KEGGihsa:22834
UCSCiuc002iov.5 human

Organism-specific databases

CTDi22834
DisGeNETi22834
EuPathDBiHostDB:ENSG00000198740.8
GeneCardsiZNF652
HGNCiHGNC:29147 ZNF652
HPAiHPA044408
MIMi613907 gene
neXtProtiNX_Q9Y2D9
OpenTargetsiENSG00000198740
PharmGKBiPA134896615
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1721 Eukaryota
COG5048 LUCA
GeneTreeiENSGT00440000037877
HOGENOMiHOG000231037
HOVERGENiHBG064823
InParanoidiQ9Y2D9
OMAiGQSEDSF
OrthoDBiEOG091G055W
PhylomeDBiQ9Y2D9
TreeFamiTF332655

Enzyme and pathway databases

SIGNORiQ9Y2D9

Miscellaneous databases

ChiTaRSiZNF652 human
GenomeRNAii22834
PROiPR:Q9Y2D9
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000198740 Expressed in 226 organ(s), highest expression level in globus pallidus
CleanExiHS_ZNF652
ExpressionAtlasiQ9Y2D9 baseline and differential
GenevisibleiQ9Y2D9 HS

Family and domain databases

InterProiView protein in InterPro
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type
PfamiView protein in Pfam
PF00096 zf-C2H2, 5 hits
SMARTiView protein in SMART
SM00355 ZnF_C2H2, 9 hits
SUPFAMiSSF57667 SSF57667, 5 hits
PROSITEiView protein in PROSITE
PS00028 ZINC_FINGER_C2H2_1, 7 hits
PS50157 ZINC_FINGER_C2H2_2, 9 hits
ProtoNetiSearch...

Entry informationi

Entry nameiZN652_HUMAN
AccessioniPrimary (citable) accession number: Q9Y2D9
Secondary accession number(s): A4QPD9, Q5H9Q0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 20, 2007
Last sequence update: March 20, 2007
Last modified: November 7, 2018
This is version 138 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
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Main funding by: National Institutes of Health

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