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Protein

Afadin- and alpha-actinin-binding protein

Gene

SSX2IP

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Belongs to an adhesion system, which plays a role in the organization of homotypic, interneuronal and heterotypic cell-cell adherens junctions (AJs). May connect the nectin-afadin and E-cadherin-catenin system through alpha-actinin and may be involved in organization of the actin cytoskeleton at AJs through afadin and alpha-actinin (By similarity). Involved in cell movement: localizes at the leading edge of moving cells in response to PDGF and is required for the formation of the leading edge and the promotion of cell movement, possibly via activation of Rac signaling (By similarity). Acts as a centrosome maturation factor, probably by maintaining the integrity of the pericentriolar material and proper microtubule nucleation at mitotic spindle poles. The function seems to implicate at least in part WRAP73; the SSX2IP:WRAP73 complex is proposed to act as regulator of spindle anchoring at the mitotic centrosome (PubMed:23816619, PubMed:26545777). Involved in ciliogenesis (PubMed:24356449). It is required for targeted recruitment of the BBSome, CEP290, RAB8, and SSTR3 to the cilia (PubMed:24356449).By similarity1 Publication2 Publications

Miscellaneous

Acts as an acute myeloid leukemia-associated antigen and may be used as a potential immunotherapy target for leukemia (PubMed:17686061, PubMed:19179477).2 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processCell adhesion, Cilium biogenesis/degradation

Protein family/group databases

MoonDB Database of extreme multifunctional and moonlighting proteins

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MoonDBi
Q9Y2D8 Predicted

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Afadin- and alpha-actinin-binding protein
Short name:
ADIP
Alternative name(s):
Afadin DIL domain-interacting protein
SSX2-interacting protein
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:SSX2IP
Synonyms:KIAA0923
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 1

Organism-specific databases

Eukaryotic Pathogen Database Resources

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EuPathDBi
HostDB:ENSG00000117155.16

Human Gene Nomenclature Database

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HGNCi
HGNC:16509 SSX2IP

Online Mendelian Inheritance in Man (OMIM)

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MIMi
608690 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q9Y2D8

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell junction, Cell projection, Cytoplasm, Cytoskeleton, Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Open Targets

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OpenTargetsi
ENSG00000117155

The Pharmacogenetics and Pharmacogenomics Knowledge Base

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PharmGKBi
PA38155

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

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BioMutai
SSX2IP

Domain mapping of disease mutations (DMDM)

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DMDMi
54035738

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000644551 – 614Afadin- and alpha-actinin-binding proteinAdd BLAST614

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei290PhosphoserineCombined sources1
Modified residuei293PhosphoserineCombined sources1
Modified residuei312PhosphoserineCombined sources1
Modified residuei536PhosphoserineCombined sources1
Modified residuei540PhosphoserineCombined sources1
Modified residuei542PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q9Y2D8

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q9Y2D8

PeptideAtlas

More...
PeptideAtlasi
Q9Y2D8

PRoteomics IDEntifications database

More...
PRIDEi
Q9Y2D8

ProteomicsDB human proteome resource

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ProteomicsDBi
85743
85744 [Q9Y2D8-2]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q9Y2D8

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q9Y2D8

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Widely expressed, with the highest expression in brain, intermediate expression in kidney, testis, spinal cord, liver, heart, lung, skeletal muscle, ovary, fetal liver and fetal brain, and little to no expression in pancreas and spleen. All specific brain regions showed intermediate to high expression, with highest expression in amygdala. Also expressed in fetal tissues, mainly in liver and brain.

<p>This subsection of the ‘Expression’ section provides information on the expression of the gene product at various stages of a cell, tissue or organism development. By default, the information is derived from experiments at the mRNA level, unless specified ‘at the protein level’.<p><a href='/help/developmental_stage' target='_top'>More...</a></p>Developmental stagei

Expressed in interphase and M phase cells. Down-regulated by the miRNA miR338-3p.2 Publications

Gene expression databases

Bgee dataBase for Gene Expression Evolution

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Bgeei
ENSG00000117155 Expressed in 202 organ(s), highest expression level in testis

CleanEx database of gene expression profiles

More...
CleanExi
HS_SSX2IP

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q9Y2D8 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q9Y2D8 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA027306
HPA075946

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with afadin and alpha-actinin (By similarity). Interacts with VAV2 (By similarity). Interacts with SSX2 and SSX3. Does not interact with SSX1 and SSX4 (PubMed:12007189). Interacts with PCM1 (By similarity). Interacts with WRAP73 (PubMed:26545777).By similarity2 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

WithEntry#Exp.IntActNotes
A8K9323EBI-2212028,EBI-10174671
ABLIM3O949293EBI-2212028,EBI-351267
AENQ8WTP83EBI-2212028,EBI-8637627
AP1M1Q9BXS53EBI-2212028,EBI-541426
BEX2Q9BXY83EBI-2212028,EBI-745073
BYSLQ138955EBI-2212028,EBI-358049
C11orf54Q9H0W93EBI-2212028,EBI-740204
CARD9Q9H2573EBI-2212028,EBI-751319
CCDC198Q9NVL83EBI-2212028,EBI-10238351
CCHCR1Q8TD31-33EBI-2212028,EBI-10175300
CCNHP519464EBI-2212028,EBI-741406
CDC23Q9UJX23EBI-2212028,EBI-396137
CDCA7LQ96GN53EBI-2212028,EBI-5278764
CEP55Q53EZ45EBI-2212028,EBI-747776
CHCHD3Q9NX633EBI-2212028,EBI-743375
DAXXQ9UER73EBI-2212028,EBI-77321
DRG1Q9Y2953EBI-2212028,EBI-719554
EHHADHQ084263EBI-2212028,EBI-2339219
EIF4A2Q142403EBI-2212028,EBI-73473
EIF4A2Q14240-23EBI-2212028,EBI-10232522
FAM124BQ9H5Z63EBI-2212028,EBI-741626
FAM161AQ3B8203EBI-2212028,EBI-719941
FAM214AQ32MH53EBI-2212028,EBI-2866142
FANCLQ9NW383EBI-2212028,EBI-2339898
FBF1Q8TES7-63EBI-2212028,EBI-10244131
FNDC11Q9BVV23EBI-2212028,EBI-744935
FRMD6Q96NE93EBI-2212028,EBI-741729
GEMP550403EBI-2212028,EBI-744104
GOLGA8GQ08AF83EBI-2212028,EBI-10181260
INO80BQ9C0863EBI-2212028,EBI-715611
KAT5Q929933EBI-2212028,EBI-399080
KLHL42Q9P2K63EBI-2212028,EBI-739890
KRT15P190123EBI-2212028,EBI-739566
KRT31Q153233EBI-2212028,EBI-948001
KRT40Q6A1623EBI-2212028,EBI-10171697
KRTAP10-7P604093EBI-2212028,EBI-10172290
LATS1Q6PJG33EBI-2212028,EBI-10253976
LMO2P257913EBI-2212028,EBI-739696
MFAP1P550813EBI-2212028,EBI-1048159
MORN4Q8NDC45EBI-2212028,EBI-10269566
MOSP005403EBI-2212028,EBI-1757866
MRPL53Q96EL33EBI-2212028,EBI-2513715
NAA10P412273EBI-2212028,EBI-747693
NOL12Q9UGY13EBI-2212028,EBI-716098
PCM1Q1515410EBI-2212028,EBI-741421
PHC2Q8IXK03EBI-2212028,EBI-713786
PIMREGQ9BSJ63EBI-2212028,EBI-2568609
PKN1Q165123EBI-2212028,EBI-602382
POLLQ9UGP5-23EBI-2212028,EBI-10320765
PRKAA1Q131313EBI-2212028,EBI-1181405
PRPF31Q8WWY36EBI-2212028,EBI-1567797
PSMA1P257863EBI-2212028,EBI-359352
RYDENQ9NUL53EBI-2212028,EBI-10313866
SCNM1Q9BWG63EBI-2212028,EBI-748391
SSX2BQ163858EBI-2212028,EBI-2210673
SSX3Q999093EBI-2212028,EBI-10295431
SYT17Q9BSW73EBI-2212028,EBI-745392
taxP034103EBI-2212028,EBI-9676218From Human T-cell leukemia virus 2.
TBPQ32MN63EBI-2212028,EBI-10239991
TEAD4D3DUQ63EBI-2212028,EBI-10176734
TFIP11Q9UBB93EBI-2212028,EBI-1105213
TOP3BO959853EBI-2212028,EBI-373403
TP53BP2Q13625-33EBI-2212028,EBI-10175039
TRIM37O949724EBI-2212028,EBI-741602
TRIM42Q8IWZ53EBI-2212028,EBI-5235829
TRIM54Q9BYV23EBI-2212028,EBI-2130429
TSTD2Q5T7W73EBI-2212028,EBI-8994397
TTC23Q5W5X93EBI-2212028,EBI-6447954
WDR5P619643EBI-2212028,EBI-540834
WRAP73Q9P2S59EBI-2212028,EBI-1054904
Wrap73Q9JM983EBI-2212028,EBI-11694665From Mus musculus.
XIAPP981703EBI-2212028,EBI-517127
ZBTB24O431673EBI-2212028,EBI-744471
ZGPATQ8N5A54EBI-2212028,EBI-3439227
ZGPATQ8N5A5-23EBI-2212028,EBI-10183064
ZMAT2Q96NC03EBI-2212028,EBI-2682299
ZNF124Q159733EBI-2212028,EBI-2555767
ZNF250P15622-35EBI-2212028,EBI-10177272
ZNF3P170363EBI-2212028,EBI-1640965
ZNF417Q8TAU33EBI-2212028,EBI-740727
ZNF587Q96SQ53EBI-2212028,EBI-6427977
ZNF688A0A0S2Z5X43EBI-2212028,EBI-16429014
ZNF792Q3KQV33EBI-2212028,EBI-10240849
ZRSR2Q156963EBI-2212028,EBI-6657923
ZSCAN12O433093EBI-2212028,EBI-1210440

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

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BioGridi
125567, 248 interactors

Protein interaction database and analysis system

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IntActi
Q9Y2D8, 314 interactors

Molecular INTeraction database

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MINTi
Q9Y2D8

STRING: functional protein association networks

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STRINGi
9606.ENSP00000340279

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
Q9Y2D8

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q9Y2D8

Database of comparative protein structure models

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ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and domains’ section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili131 – 227Sequence analysisAdd BLAST97
Coiled coili266 – 293Sequence analysisAdd BLAST28
Coiled coili374 – 460Sequence analysisAdd BLAST87

<p>This subsection of the ‘Family and domains’ section provides general information on the biological role of a domain. The term ‘domain’ is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

Both the N-terminal (up to position 79) and the C-terminal (from position 304) sequences are required for interaction with SSX2.

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the ADIP family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410IED3 Eukaryota
ENOG410XWZ9 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00390000007688

The HOVERGEN Database of Homologous Vertebrate Genes

More...
HOVERGENi
HBG050460

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
Q9Y2D8

KEGG Orthology (KO)

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KOi
K06085

Identification of Orthologs from Complete Genome Data

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OMAi
LQNCYAK

Database of Orthologous Groups

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OrthoDBi
EOG091G0HRZ

Database for complete collections of gene phylogenies

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PhylomeDBi
Q9Y2D8

TreeFam database of animal gene trees

More...
TreeFami
TF332889

Family and domain databases

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR021622 Afadin/alpha-actinin-bd

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF11559 ADIP, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 3 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 3 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q9Y2D8-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MGDWMTVTDP GLSSESKTIS QYTSETKMSP SSLYSQQVLC SSIPLSKNVH
60 70 80 90 100
SFFSAFCTED NIEQSISYLD QELTTFGFPS LYEESKGKET KRELNIVAVL
110 120 130 140 150
NCMNELLVLQ RKNLLAQENV ETQNLKLGSD MDHLQSCYSK LKEQLETSRR
160 170 180 190 200
EMIGLQERDR QLQCKNRNLH QLLKNEKDEV QKLQNIIASR ATQYNHDMKR
210 220 230 240 250
KEREYNKLKE RLHQLVMNKK DKKIAMDILN YVGRADGKRG SWRTGKTEAR
260 270 280 290 300
NEDEMYKILL NDYEYRQKQI LMENAELKKV LQQMKKEMIS LLSPQKKKPR
310 320 330 340 350
ERVDDSTGTV ISDVEEDAGE LSRESMWDLS CETVREQLTN SIRKQWRILK
360 370 380 390 400
SHVEKLDNQV SKVHLEGFND EDVISRQDHE QETEKLELEI QQCKEMIKTQ
410 420 430 440 450
QQLLQQQLAT AYDDDTTSLL RDCYLLEEKE RLKEEWSLFK EQKKNFERER
460 470 480 490 500
RSFTEAAIRL GLERKAFEEE RASWLKQQFL NMTTFDHQNS ENVKLFSAFS
510 520 530 540 550
GSSDWDNLIV HSRQPQKKPH SVSNGSPVCM SKLTKSLPAS PSTSDFCQTR
560 570 580 590 600
SCISEHSSIN VLNITAEEIK PNQVGGECTN QKWSVASRPG SQEGCYSGCS
610
LSYTNSHVEK DDLP
Length:614
Mass (Da):71,236
Last modified:October 11, 2004 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i427903EF86A6FE31
GO
Isoform 2 (identifier: Q9Y2D8-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     557-560: SSIN → RAKN
     561-614: Missing.

Note: No experimental confirmation available.
Show »
Length:560
Mass (Da):65,494
Checksum:i6801860E2CDEFDF5
GO
Isoform 3 (identifier: Q9Y2D8-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-27: Missing.

Note: No experimental confirmation available.
Show »
Length:587
Mass (Da):68,274
Checksum:i2E42AE655DD8EF27
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
S4R403S4R403_HUMAN
Afadin- and alpha-actinin-binding p...
SSX2IP
504Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
C9JIX7C9JIX7_HUMAN
Afadin- and alpha-actinin-binding p...
SSX2IP
180Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
S4R2Y6S4R2Y6_HUMAN
Afadin- and alpha-actinin-binding p...
SSX2IP
87Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence BAA76767 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti232V → A in AAQ72373 (Ref. 2) Curated1
Sequence conflicti405Missing in AAH64389 (PubMed:15489334).Curated1
Sequence conflicti576G → V in AAQ72373 (Ref. 2) Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_056726578C → R2 PublicationsCorresponds to variant dbSNP:rs1057746Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting. The information stored in this subsection is used to automatically construct alternative protein sequence(s) for display.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0463681 – 27Missing in isoform 3. 1 PublicationAdd BLAST27
Alternative sequenceiVSP_011724557 – 560SSIN → RAKN in isoform 2. 1 Publication4
Alternative sequenceiVSP_011725561 – 614Missing in isoform 2. 1 PublicationAdd BLAST54

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
AY367055 mRNA Translation: AAQ72373.1
AB023140 mRNA Translation: BAA76767.2 Different initiation.
AK292475 mRNA Translation: BAF85164.1
AK294057 mRNA Translation: BAG57404.1
AL133046 mRNA Translation: CAB61373.1
AC114482 Genomic DNA No translation available.
CH471097 Genomic DNA Translation: EAW73224.1
CH471097 Genomic DNA Translation: EAW73226.1
CH471097 Genomic DNA Translation: EAW73227.1
CH471097 Genomic DNA Translation: EAW73228.1
BC033637 mRNA Translation: AAH33637.1
BC064389 mRNA Translation: AAH64389.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS53337.1 [Q9Y2D8-3]
CCDS699.1 [Q9Y2D8-1]

Protein sequence database of the Protein Information Resource

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PIRi
T42649

NCBI Reference Sequences

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RefSeqi
NP_001159765.1, NM_001166293.1 [Q9Y2D8-1]
NP_001159766.1, NM_001166294.1 [Q9Y2D8-3]
NP_001159767.1, NM_001166295.1 [Q9Y2D8-3]
NP_001159889.1, NM_001166417.1 [Q9Y2D8-1]
NP_054740.3, NM_014021.3 [Q9Y2D8-1]
XP_005270484.1, XM_005270427.1 [Q9Y2D8-1]
XP_005270485.1, XM_005270428.1 [Q9Y2D8-1]
XP_006710394.1, XM_006710331.1 [Q9Y2D8-3]
XP_011538912.1, XM_011540610.1
XP_016855723.1, XM_017000234.1 [Q9Y2D8-1]

UniGene gene-oriented nucleotide sequence clusters

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UniGenei
Hs.22587

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENST00000342203; ENSP00000340279; ENSG00000117155 [Q9Y2D8-1]
ENST00000437941; ENSP00000412781; ENSG00000117155 [Q9Y2D8-3]
ENST00000481102; ENSP00000432261; ENSG00000117155 [Q9Y2D8-2]
ENST00000605755; ENSP00000474480; ENSG00000117155 [Q9Y2D8-3]

Database of genes from NCBI RefSeq genomes

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GeneIDi
117178

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:117178

UCSC genome browser

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UCSCi
uc001dkj.4 human [Q9Y2D8-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross_references_section">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY367055 mRNA Translation: AAQ72373.1
AB023140 mRNA Translation: BAA76767.2 Different initiation.
AK292475 mRNA Translation: BAF85164.1
AK294057 mRNA Translation: BAG57404.1
AL133046 mRNA Translation: CAB61373.1
AC114482 Genomic DNA No translation available.
CH471097 Genomic DNA Translation: EAW73224.1
CH471097 Genomic DNA Translation: EAW73226.1
CH471097 Genomic DNA Translation: EAW73227.1
CH471097 Genomic DNA Translation: EAW73228.1
BC033637 mRNA Translation: AAH33637.1
BC064389 mRNA Translation: AAH64389.1
CCDSiCCDS53337.1 [Q9Y2D8-3]
CCDS699.1 [Q9Y2D8-1]
PIRiT42649
RefSeqiNP_001159765.1, NM_001166293.1 [Q9Y2D8-1]
NP_001159766.1, NM_001166294.1 [Q9Y2D8-3]
NP_001159767.1, NM_001166295.1 [Q9Y2D8-3]
NP_001159889.1, NM_001166417.1 [Q9Y2D8-1]
NP_054740.3, NM_014021.3 [Q9Y2D8-1]
XP_005270484.1, XM_005270427.1 [Q9Y2D8-1]
XP_005270485.1, XM_005270428.1 [Q9Y2D8-1]
XP_006710394.1, XM_006710331.1 [Q9Y2D8-3]
XP_011538912.1, XM_011540610.1
XP_016855723.1, XM_017000234.1 [Q9Y2D8-1]
UniGeneiHs.22587

3D structure databases

ProteinModelPortaliQ9Y2D8
SMRiQ9Y2D8
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi125567, 248 interactors
IntActiQ9Y2D8, 314 interactors
MINTiQ9Y2D8
STRINGi9606.ENSP00000340279

Protein family/group databases

MoonDBiQ9Y2D8 Predicted

PTM databases

iPTMnetiQ9Y2D8
PhosphoSitePlusiQ9Y2D8

Polymorphism and mutation databases

BioMutaiSSX2IP
DMDMi54035738

Proteomic databases

EPDiQ9Y2D8
PaxDbiQ9Y2D8
PeptideAtlasiQ9Y2D8
PRIDEiQ9Y2D8
ProteomicsDBi85743
85744 [Q9Y2D8-2]

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
117178
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000342203; ENSP00000340279; ENSG00000117155 [Q9Y2D8-1]
ENST00000437941; ENSP00000412781; ENSG00000117155 [Q9Y2D8-3]
ENST00000481102; ENSP00000432261; ENSG00000117155 [Q9Y2D8-2]
ENST00000605755; ENSP00000474480; ENSG00000117155 [Q9Y2D8-3]
GeneIDi117178
KEGGihsa:117178
UCSCiuc001dkj.4 human [Q9Y2D8-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
117178
EuPathDBiHostDB:ENSG00000117155.16

GeneCards: human genes, protein and diseases

More...
GeneCardsi
SSX2IP
HGNCiHGNC:16509 SSX2IP
HPAiHPA027306
HPA075946
MIMi608690 gene
neXtProtiNX_Q9Y2D8
OpenTargetsiENSG00000117155
PharmGKBiPA38155

Human Unidentified Gene-Encoded large proteins database

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HUGEi
Search...

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiENOG410IED3 Eukaryota
ENOG410XWZ9 LUCA
GeneTreeiENSGT00390000007688
HOVERGENiHBG050460
InParanoidiQ9Y2D8
KOiK06085
OMAiLQNCYAK
OrthoDBiEOG091G0HRZ
PhylomeDBiQ9Y2D8
TreeFamiTF332889

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
SSX2IP human

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
SSX2IP

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
117178

Protein Ontology

More...
PROi
PR:Q9Y2D8

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000117155 Expressed in 202 organ(s), highest expression level in testis
CleanExiHS_SSX2IP
ExpressionAtlasiQ9Y2D8 baseline and differential
GenevisibleiQ9Y2D8 HS

Family and domain databases

InterProiView protein in InterPro
IPR021622 Afadin/alpha-actinin-bd
PfamiView protein in Pfam
PF11559 ADIP, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiADIP_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9Y2D8
Secondary accession number(s): A8K8W0
, B4DFE3, D3DT13, J3KR02, Q6P2P8, Q6ULS1, Q7L168, Q9UIX0
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 11, 2004
Last sequence update: October 11, 2004
Last modified: December 5, 2018
This is version 155 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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