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Protein

A-kinase anchor protein 2

Gene

AKAP2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Binds to regulatory subunit (RII) of protein kinase A. May be involved in establishing polarity in signaling systems or in integrating PKA-RII isoforms with downstream effectors to capture, amplify and focus diffuse, trans-cellular signals carried by cAMP (By similarity).By similarity

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
A-kinase anchor protein 2
Short name:
AKAP-2
Alternative name(s):
AKAP-KL
Protein kinase A-anchoring protein 2
Short name:
PRKA2
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:AKAP2
Synonyms:KIAA0920, PRKA2
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 9

Organism-specific databases

Eukaryotic Pathogen Database Resources

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EuPathDBi
HostDB:ENSG00000241978.9

Human Gene Nomenclature Database

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HGNCi
HGNC:372 AKAP2

Online Mendelian Inheritance in Man (OMIM)

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MIMi
604582 gene

neXtProt; the human protein knowledge platform

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neXtProti
NX_Q9Y2D5

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

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DisGeNETi
11217
445815

Open Targets

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OpenTargetsi
ENSG00000157654
ENSG00000241978

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA162398639

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

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BioMutai
AKAP2

Domain mapping of disease mutations (DMDM)

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DMDMi
254763433

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000645241 – 859A-kinase anchor protein 2Add BLAST859

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei91PhosphoserineCombined sources1
Modified residuei121PhosphoserineCombined sources1
Modified residuei152PhosphoserineCombined sources1
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section describes <strong>covalent linkages</strong> of various types formed <strong>between two proteins (interchain cross-links)</strong> or <strong>between two parts of the same protein (intrachain cross-links)</strong>, except the disulfide bonds that are annotated in the <a href="http://www.uniprot.org/manual/disulfid">'Disulfide bond'</a> subsection.<p><a href='/help/crosslnk' target='_top'>More...</a></p>Cross-linki174Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO1); alternateCombined sources
Cross-linki174Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternateCombined sources
Modified residuei336PhosphoserineBy similarity1
Modified residuei393PhosphoserineCombined sources1
Modified residuei461PhosphoserineCombined sources1
Modified residuei465PhosphoserineBy similarity1
Modified residuei517PhosphoserineCombined sources1
Modified residuei526PhosphothreonineCombined sources1
Modified residuei631PhosphoserineCombined sources1
Modified residuei720PhosphoserineCombined sources1
Modified residuei748PhosphoserineCombined sources1
Modified residuei778PhosphoserineCombined sources1
Modified residuei785PhosphoserineCombined sources1

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - PTMi

Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

Encyclopedia of Proteome Dynamics

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EPDi
Q9Y2D5

PaxDb, a database of protein abundance averages across all three domains of life

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PaxDbi
Q9Y2D5

PeptideAtlas

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PeptideAtlasi
Q9Y2D5

PRoteomics IDEntifications database

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PRIDEi
Q9Y2D5

ProteomicsDB human proteome resource

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ProteomicsDBi
85738
85739 [Q9Y2D5-4]
85740 [Q9Y2D5-5]
85741 [Q9Y2D5-6]
85742 [Q9Y2D5-7]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

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iPTMneti
Q9Y2D5

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

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PhosphoSitePlusi
Q9Y2D5

SwissPalm database of S-palmitoylation events

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SwissPalmi
Q9Y2D5

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

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Bgeei
ENSG00000241978 Expressed in 95 organ(s), highest expression level in adipose tissue

CleanEx database of gene expression profiles

More...
CleanExi
HS_AKAP2

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
Q9Y2D5 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
Q9Y2D5 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA058905

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

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BioGridi
116386, 40 interactors
138657, 7 interactors

Protein interaction database and analysis system

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IntActi
Q9Y2D5, 37 interactors

STRING: functional protein association networks

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STRINGi
9606.ENSP00000451476

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

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ProteinModelPortali
Q9Y2D5

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
Q9Y2D5

Database of comparative protein structure models

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ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni566 – 579PKA-RII subunit binding domainAdd BLAST14

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and domains’ section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili213 – 290Sequence analysisAdd BLAST78
Coiled coili710 – 748Sequence analysisAdd BLAST39

<p>This subsection of the ‘Family and domains’ section provides general information on the biological role of a domain. The term ‘domain’ is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The RII-alpha binding site, predicted to form an amphipathic helix, could participate in protein-protein interactions with a complementary surface on the R-subunit dimer.

Keywords - Domaini

Coiled coil

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
ENOG410IG9A Eukaryota
ENOG410ZMFZ LUCA

Ensembl GeneTree

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GeneTreei
ENSGT00930000151059

The HOVERGEN Database of Homologous Vertebrate Genes

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HOVERGENi
HBG050477

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
Q9Y2D5

KEGG Orthology (KO)

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KOi
K16519

Identification of Orthologs from Complete Genome Data

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OMAi
PPDHKNM

Database of Orthologous Groups

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OrthoDBi
EOG091G012B

Database for complete collections of gene phylogenies

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PhylomeDBi
Q9Y2D5

TreeFam database of animal gene trees

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TreeFami
TF105402

Family and domain databases

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR029304 AKAP2_C

Pfam protein domain database

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Pfami
View protein in Pfam
PF15304 AKAP2_C, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (5+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 5 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 5 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q9Y2D5-3) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MEIEVSVAEC KSVPGITSTP HPMDHPSAFY SPPHNGLLTD HHESLDNDVA
60 70 80 90 100
REIRYLDEVL EANCCDSAVD GTYNGTSSPE PGAVVLVGGL SPPVHEATQP
110 120 130 140 150
EPTERTASRQ APPHIELSNS SPDPMAEAER TNGHSPSQPR DALGDSLQVP
160 170 180 190 200
VSPSSTTSSR CSSRDGEFTL TTLKKEAKFE LRAFHEDKKP SKLFEDDEHE
210 220 230 240 250
KEQYCIRKVR PSEEMLELEK ERRELIRSQA VKKNPGIAAK WWNPPQEKTI
260 270 280 290 300
EEQLDEEHLE SHKKYKERKE RRAQQEQLLL QKQLQQQQQQ PPSQLCTAPA
310 320 330 340 350
SSHERASMID KAKEDIVTEQ IDFSAARKQF QLMENSRQAV AKGQSTPRLF
360 370 380 390 400
SIKPFYRPLG SVNSDKPLTN PRPPSVGGPP EDSGASAAKG QKSPGALETP
410 420 430 440 450
SAAGSQGNTA SQGKEGPYSE PSKRGPLSKL WAEDGEFTSA RAVLTVVKDD
460 470 480 490 500
DHGILDQFSR SVNVSLTQEE LDSGLDELSV RSQDTTVLET LSNDFSMDNI
510 520 530 540 550
SDSGASNETT NALQENSLAD FSLPQTPQTD NPSEGRGEGV SKSFSDHGFY
560 570 580 590 600
SPSSTLGDSP LVDDPLEYQA GLLVQNAIQQ AIAEQVDKAV SKTSRDGAEQ
610 620 630 640 650
QGPEATVEEA EAAAFGSEKP QSMFEPPQVS SPVQEKRDVL PKILPAEDRA
660 670 680 690 700
LRERGPPQPL PAVQPSGPIN MEETRPEGSY FSKYSEAAEL RSTASLLATQ
710 720 730 740 750
ESDVMVGPFK LRSRKQRTLS MIEEEIRAAQ EREEELKRQR QVLQSTQSPR
760 770 780 790 800
TKNAPSLPSR TCYKTAPGKI EKVKPPPSPT TEGPSLQPDL APEEAAGTQR
810 820 830 840 850
PKNLMQTLME DYETHKSKRR ERMDDSSVLE ATRVNRRKSA LALRWEAGIY

ANQEEEDNE
Length:859
Mass (Da):94,661
Last modified:July 28, 2009 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i6DCE563596DFBA4B
GO
Isoform 3 (identifier: Q9Y2D5-4) [UniParc]FASTAAdd to basket
Also known as: PALM2-AKAP2

The sequence of this isoform differs from the canonical sequence as follows:
     1-1: M → MAEAELHKER...SSLSPDHKNM
     827-827: S → SYTSKLLSCKVTSE

Note: Based on a naturally occurring readthrough transcript which produces a PALM2-AKAP2 fusion protein.
Show »
Length:1,103
Mass (Da):122,071
Checksum:iB501182135112FE5
GO
Isoform 2 (identifier: Q9Y2D5-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-1: M → MRWPQPGAAA...SSLSPDHKNM

Show »
Length:948
Mass (Da):104,107
Checksum:i9DBF30D86F05F61F
GO
Isoform 4 (identifier: Q9Y2D5-6) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-1: M → MAEAELHKER...SSLSPDHKNM

Note: Based on a naturally occurring readthrough transcript which produces a PALM2-AKAP2 fusion protein.
Show »
Length:1,090
Mass (Da):120,630
Checksum:i51F5C843CC9C1A4C
GO
Isoform 5 (identifier: Q9Y2D5-7) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-1: M → MRWPQPGAAA...SSLSPDHKNM
     827-827: S → SYTSKLLSCKVTSE

Show »
Length:961
Mass (Da):105,548
Checksum:iD2BF4A482F710D91
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
C9JVY5C9JVY5_HUMAN
A-kinase anchor protein 2
AKAP2
778Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F8WF36F8WF36_HUMAN
A-kinase anchor protein 2
AKAP2
54Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence BAA76764 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti282K → Q in BAG51862 (PubMed:14702039).Curated1
Sequence conflicti282K → Q in BAG62154 (PubMed:14702039).Curated1
Sequence conflicti282K → Q in AAI46864 (PubMed:15489334).Curated1
Sequence conflicti282K → Q in AAI71800 (PubMed:15489334).Curated1
Sequence conflicti647E → G in CAB53707 (PubMed:17974005).Curated1
Sequence conflicti651L → P in BAG51862 (PubMed:14702039).Curated1
Sequence conflicti719L → S in BAG51862 (PubMed:14702039).Curated1
Isoform 2 (identifier: Q9Y2D5-5)
Sequence conflicti20P → L in AAI46864 (PubMed:15489334).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_024248561L → S2 PublicationsCorresponds to variant dbSNP:rs914358Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting. The information stored in this subsection is used to automatically construct alternative protein sequence(s) for display.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0377701M → MRWPQPGAAARLPPESPGPP ESPGPPEREAAAARRWTGAE PQDCAPGSGRPEKPPQLSED DIWLKSEGDNYSATLLEPAA SSLSPDHKNM in isoform 2 and isoform 5. 2 Publications1
Alternative sequenceiVSP_0377691M → MAEAELHKERLQAIAEKRKR QTEIEGKRQQLDEQILLLQH SKSKVLREKWLLQGIPAGTA EEEEARRRQSEEDEFRVKQL EDNIQRLEQEIQTLESEESQ ISAKEQIILEKLKETEKSFK DFQKGFSSTDGDAVNYISSQ LPDLPILCSRTAEPSPGQDG TSRAAGVGWENVLLKEGESA SNATETSGPDMTIKKPPQLS EDDIWLKSEGDNYSATLLEP AASSLSPDHKNM in isoform 3 and isoform 4. 3 Publications1
Alternative sequenceiVSP_037771827S → SYTSKLLSCKVTSE in isoform 3 and isoform 5. 3 Publications1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
AJ303079 mRNA Translation: CAC38839.1
AB023137 mRNA Translation: BAA76764.2 Different initiation.
AK057098 mRNA Translation: BAG51862.1
AK300427 mRNA Translation: BAG62154.1
AL158823 Genomic DNA No translation available.
AL158829 Genomic DNA No translation available.
AL353598 Genomic DNA No translation available.
AL353806 Genomic DNA No translation available.
AL627225 Genomic DNA No translation available.
CH471105 Genomic DNA Translation: EAW59057.1
BC140818 mRNA Translation: AAI40819.1
BC146863 mRNA Translation: AAI46864.1
BC171800 mRNA Translation: AAI71800.1
AL110268 mRNA Translation: CAB53707.1

The Consensus CDS (CCDS) project

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CCDSi
CCDS43861.1 [Q9Y2D5-5]
CCDS48003.1 [Q9Y2D5-3]
CCDS56581.1 [Q9Y2D5-7]

Protein sequence database of the Protein Information Resource

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PIRi
T14787

NCBI Reference Sequences

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RefSeqi
NP_001004065.2, NM_001004065.4 [Q9Y2D5-5]
NP_001130034.1, NM_001136562.2 [Q9Y2D5-3]
NP_001185585.1, NM_001198656.1 [Q9Y2D5-7]
NP_009134.1, NM_007203.4 [Q9Y2D5-4]
NP_671492.1, NM_147150.2 [Q9Y2D5-6]

UniGene gene-oriented nucleotide sequence clusters

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UniGenei
Hs.591908

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000259318; ENSP00000259318; ENSG00000241978 [Q9Y2D5-3]
ENST00000374525; ENSP00000363649; ENSG00000241978 [Q9Y2D5-5]
ENST00000434623; ENSP00000404782; ENSG00000241978 [Q9Y2D5-7]

Database of genes from NCBI RefSeq genomes

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GeneIDi
11217
445815

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:11217
hsa:445815

UCSC genome browser

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UCSCi
uc004bem.4 human [Q9Y2D5-3]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ303079 mRNA Translation: CAC38839.1
AB023137 mRNA Translation: BAA76764.2 Different initiation.
AK057098 mRNA Translation: BAG51862.1
AK300427 mRNA Translation: BAG62154.1
AL158823 Genomic DNA No translation available.
AL158829 Genomic DNA No translation available.
AL353598 Genomic DNA No translation available.
AL353806 Genomic DNA No translation available.
AL627225 Genomic DNA No translation available.
CH471105 Genomic DNA Translation: EAW59057.1
BC140818 mRNA Translation: AAI40819.1
BC146863 mRNA Translation: AAI46864.1
BC171800 mRNA Translation: AAI71800.1
AL110268 mRNA Translation: CAB53707.1
CCDSiCCDS43861.1 [Q9Y2D5-5]
CCDS48003.1 [Q9Y2D5-3]
CCDS56581.1 [Q9Y2D5-7]
PIRiT14787
RefSeqiNP_001004065.2, NM_001004065.4 [Q9Y2D5-5]
NP_001130034.1, NM_001136562.2 [Q9Y2D5-3]
NP_001185585.1, NM_001198656.1 [Q9Y2D5-7]
NP_009134.1, NM_007203.4 [Q9Y2D5-4]
NP_671492.1, NM_147150.2 [Q9Y2D5-6]
UniGeneiHs.591908

3D structure databases

ProteinModelPortaliQ9Y2D5
SMRiQ9Y2D5
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi116386, 40 interactors
138657, 7 interactors
IntActiQ9Y2D5, 37 interactors
STRINGi9606.ENSP00000451476

PTM databases

iPTMnetiQ9Y2D5
PhosphoSitePlusiQ9Y2D5
SwissPalmiQ9Y2D5

Polymorphism and mutation databases

BioMutaiAKAP2
DMDMi254763433

Proteomic databases

EPDiQ9Y2D5
PaxDbiQ9Y2D5
PeptideAtlasiQ9Y2D5
PRIDEiQ9Y2D5
ProteomicsDBi85738
85739 [Q9Y2D5-4]
85740 [Q9Y2D5-5]
85741 [Q9Y2D5-6]
85742 [Q9Y2D5-7]

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000259318; ENSP00000259318; ENSG00000241978 [Q9Y2D5-3]
ENST00000374525; ENSP00000363649; ENSG00000241978 [Q9Y2D5-5]
ENST00000434623; ENSP00000404782; ENSG00000241978 [Q9Y2D5-7]
GeneIDi11217
445815
KEGGihsa:11217
hsa:445815
UCSCiuc004bem.4 human [Q9Y2D5-3]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
11217
445815
DisGeNETi11217
445815
EuPathDBiHostDB:ENSG00000241978.9

GeneCards: human genes, protein and diseases

More...
GeneCardsi
AKAP2
HGNCiHGNC:372 AKAP2
HPAiHPA058905
MIMi604582 gene
neXtProtiNX_Q9Y2D5
OpenTargetsiENSG00000157654
ENSG00000241978
PharmGKBiPA162398639

Human Unidentified Gene-Encoded large proteins database

More...
HUGEi
Search...

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiENOG410IG9A Eukaryota
ENOG410ZMFZ LUCA
GeneTreeiENSGT00930000151059
HOVERGENiHBG050477
InParanoidiQ9Y2D5
KOiK16519
OMAiPPDHKNM
OrthoDBiEOG091G012B
PhylomeDBiQ9Y2D5
TreeFamiTF105402

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
AKAP2 human

The Gene Wiki collection of pages on human genes and proteins

More...
GeneWikii
AKAP2

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000241978 Expressed in 95 organ(s), highest expression level in adipose tissue
CleanExiHS_AKAP2
ExpressionAtlasiQ9Y2D5 baseline and differential
GenevisibleiQ9Y2D5 HS

Family and domain databases

InterProiView protein in InterPro
IPR029304 AKAP2_C
PfamiView protein in Pfam
PF15304 AKAP2_C, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiAKAP2_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9Y2D5
Secondary accession number(s): B1ALX9
, B2RTU4, B3KQ00, B4DTZ2, B7ZW07, B9EJB5, Q9UG26
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 21, 2001
Last sequence update: July 28, 2009
Last modified: December 5, 2018
This is version 156 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 9
    Human chromosome 9: entries, gene names and cross-references to MIM
  2. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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