Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Entry version 141 (07 Oct 2020)
Sequence version 3 (05 Apr 2011)
Previous versions | rss
Help videoAdd a publicationFeedback
Protein

Exocyst complex component 6B

Gene

EXOC6B

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processExocytosis, Protein transport, Transport

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...
PathwayCommonsi
Q9Y2D4

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Exocyst complex component 6B
Alternative name(s):
Exocyst complex component Sec15B
SEC15-like protein 2
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:EXOC6B
Synonyms:KIAA0919, SEC15B, SEC15L2
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 2

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000144036.15

Human Gene Nomenclature Database

More...
HGNCi
HGNC:17085, EXOC6B

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
607880, gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q9Y2D4

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the 'Pathology and Biotech' section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Spondyloepimetaphyseal dysplasia with joint laxity, 3 (SEMDJL3)2 Publications
The disease may be caused by mutations affecting the gene represented in this entry.
Disease descriptionAn autosomal recessive bone disease characterized by multiple joint dislocations at birth, severe joint laxity, scoliosis, gracile metacarpals and metatarsals, delayed bone age and poorly ossified carpal and tarsal bones.
Related information in OMIM
Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_082175302 – 811Missing in SEMDJL3; unknown pathological significance. 1 PublicationAdd BLAST510

Keywords - Diseasei

Disease mutation, Dwarfism

Organism-specific databases

DisGeNET

More...
DisGeNETi
23233

MalaCards human disease database

More...
MalaCardsi
EXOC6B
MIMi618395, phenotype

Open Targets

More...
OpenTargetsi
ENSG00000144036

Orphanet; a database dedicated to information on rare diseases and orphan drugs

More...
Orphaneti
93359, Spondyloepimetaphyseal dysplasia with joint laxity

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA162385463

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q9Y2D4, Tdark

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
EXOC6B

Domain mapping of disease mutations (DMDM)

More...
DMDMi
327478583

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001189541 – 811Exocyst complex component 6BAdd BLAST811

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q9Y2D4

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q9Y2D4

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
Q9Y2D4

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q9Y2D4

PeptideAtlas

More...
PeptideAtlasi
Q9Y2D4

PRoteomics IDEntifications database

More...
PRIDEi
Q9Y2D4

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
85736 [Q9Y2D4-1]
85737 [Q9Y2D4-2]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q9Y2D4

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q9Y2D4

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000144036, Expressed in corpus callosum and 220 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q9Y2D4, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q9Y2D4, HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
ENSG00000144036, Tissue enhanced (heart)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

The exocyst complex is composed of SEC3, SEC5, SEC6, SEC8, SEC10, SEC15, EXO70 and EXO84.

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
116838, 23 interactors

ComplexPortal: manually curated resource of macromolecular complexes

More...
ComplexPortali
CPX-4944, Exocyst, EXOC6B variant

Protein interaction database and analysis system

More...
IntActi
Q9Y2D4, 16 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000272427

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q9Y2D4, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q9Y2D4

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili50 – 119Sequence analysisAdd BLAST70

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the SEC15 family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG2176, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00390000005739

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_009437_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q9Y2D4

KEGG Orthology (KO)

More...
KOi
K19985

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q9Y2D4

TreeFam database of animal gene trees

More...
TreeFami
TF315199

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.10.357.30, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR007225, EXOC6/Sec15
IPR042045, EXOC6/Sec15_C_dom1

The PANTHER Classification System

More...
PANTHERi
PTHR12702, PTHR12702, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF04091, Sec15, 1 hit

PIRSF; a whole-protein classification database

More...
PIRSFi
PIRSF025007, Sec15, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 3 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q9Y2D4-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MERGKMAEAE SLETAAEHER ILREIESTDT ACIGPTLRSV YDGEEHGRFM
60 70 80 90 100
EKLETRIRNH DREIEKMCNF HYQGFVDSIT ELLKVRGEAQ KLKNQVTDTN
110 120 130 140 150
RKLQHEGKEL VIAMEELKQC RLQQRNISAT VDKLMLCLPV LEMYSKLRDQ
160 170 180 190 200
MKTKRHYPAL KTLEHLEHTY LPQVSHYRFC KVMVDNIPKL REEIKDVSMS
210 220 230 240 250
DLKDFLESIR KHSDKIGETA MKQAQQQRNL DNIVLQQPRI GSKRKSKKDA
260 270 280 290 300
YIIFDTEIES TSPKSEQDSG ILDVEDEEDD EEVPGAQDLV DFSPVYRCLH
310 320 330 340 350
IYSVLGARET FENYYRKQRR KQARLVLQPP SNMHETLDGY RKYFNQIVGF
360 370 380 390 400
FVVEDHILHT TQGLVNRAYI DELWEMALSK TIAALRTHSS YCSDPNLVLD
410 420 430 440 450
LKNLIVLFAD TLQVYGFPVN QLFDMLLEIR DQYSETLLKK WAGIFRNILD
460 470 480 490 500
SDNYSPIPVT SEEMYKKVVG QFPFQDIELE KQPFPKKFPF SEFVPKVYNQ
510 520 530 540 550
IKEFIYACLK FSEDLHLSST EVDDMIRKST NLLLTRTLSN SLQNVIKRKN
560 570 580 590 600
IGLTELVQII INTTHLEKSC KYLEEFITNI TNVLPETVHT TKLYGTTTFK
610 620 630 640 650
DARHAAEEEI YTNLNQKIDQ FLQLADYDWM TGDLGNKASD YLVDLIAFLR
660 670 680 690 700
STFAVFTHLP GKVAQTACMS ACKHLATSLM QLLLEAEVRQ LTLGALQQFN
710 720 730 740 750
LDVRECEQFA RSGPVPGFQE DTLQLAFIDL RQLLDLFIQW DWSTYLADYG
760 770 780 790 800
QPNCKYLRVN PVTALTLLEK MKDTSRKNNM FAQFRKNERD KQKLIDTVAK
810
QLRGLISSHH S
Length:811
Mass (Da):94,201
Last modified:April 5, 2011 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iA666EC6A0B82D9A2
GO
Isoform 2 (identifier: Q9Y2D4-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     661-672: GKVAQTACMSAC → VSGSCSYFVLYI
     673-811: Missing.

Show »
Length:672
Mass (Da):78,234
Checksum:i887F48FFE59B94D1
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A0U1RRB6A0A0U1RRB6_HUMAN
Exocyst complex component
EXOC6B
815Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
J3QT38J3QT38_HUMAN
Exocyst complex component
EXOC6B
681Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F8W6R7F8W6R7_HUMAN
Exocyst complex component 6B
EXOC6B
40Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence BAA76763 differs from that shown. Reason: Erroneous initiation. Extended N-terminus.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_082175302 – 811Missing in SEMDJL3; unknown pathological significance. 1 PublicationAdd BLAST510

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_040838661 – 672GKVAQ…CMSAC → VSGSCSYFVLYI in isoform 2. 1 PublicationAdd BLAST12
Alternative sequenceiVSP_040839673 – 811Missing in isoform 2. 1 PublicationAdd BLAST139

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AB023136 mRNA Translation: BAA76763.1 Different initiation.
AC006461 Genomic DNA No translation available.
AC016770 Genomic DNA No translation available.
AC092630 Genomic DNA No translation available.
AC104309 Genomic DNA No translation available.
AC105051 Genomic DNA No translation available.
BC160001 mRNA No translation available.

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS46333.1 [Q9Y2D4-1]

NCBI Reference Sequences

More...
RefSeqi
NP_056004.1, NM_015189.2 [Q9Y2D4-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000272427; ENSP00000272427; ENSG00000144036 [Q9Y2D4-1]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
23233

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:23233

UCSC genome browser

More...
UCSCi
uc010fep.4, human [Q9Y2D4-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB023136 mRNA Translation: BAA76763.1 Different initiation.
AC006461 Genomic DNA No translation available.
AC016770 Genomic DNA No translation available.
AC092630 Genomic DNA No translation available.
AC104309 Genomic DNA No translation available.
AC105051 Genomic DNA No translation available.
BC160001 mRNA No translation available.
CCDSiCCDS46333.1 [Q9Y2D4-1]
RefSeqiNP_056004.1, NM_015189.2 [Q9Y2D4-1]

3D structure databases

SMRiQ9Y2D4
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi116838, 23 interactors
ComplexPortaliCPX-4944, Exocyst, EXOC6B variant
IntActiQ9Y2D4, 16 interactors
STRINGi9606.ENSP00000272427

PTM databases

iPTMnetiQ9Y2D4
PhosphoSitePlusiQ9Y2D4

Polymorphism and mutation databases

BioMutaiEXOC6B
DMDMi327478583

Proteomic databases

EPDiQ9Y2D4
jPOSTiQ9Y2D4
MassIVEiQ9Y2D4
PaxDbiQ9Y2D4
PeptideAtlasiQ9Y2D4
PRIDEiQ9Y2D4
ProteomicsDBi85736 [Q9Y2D4-1]
85737 [Q9Y2D4-2]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...
Antibodypediai
56922, 61 antibodies

The DNASU plasmid repository

More...
DNASUi
23233

Genome annotation databases

EnsembliENST00000272427; ENSP00000272427; ENSG00000144036 [Q9Y2D4-1]
GeneIDi23233
KEGGihsa:23233
UCSCiuc010fep.4, human [Q9Y2D4-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
23233
DisGeNETi23233
EuPathDBiHostDB:ENSG00000144036.15

GeneCards: human genes, protein and diseases

More...
GeneCardsi
EXOC6B
HGNCiHGNC:17085, EXOC6B
HPAiENSG00000144036, Tissue enhanced (heart)
MalaCardsiEXOC6B
MIMi607880, gene
618395, phenotype
neXtProtiNX_Q9Y2D4
OpenTargetsiENSG00000144036
Orphaneti93359, Spondyloepimetaphyseal dysplasia with joint laxity
PharmGKBiPA162385463

Human Unidentified Gene-Encoded large proteins database

More...
HUGEi
Search...

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG2176, Eukaryota
GeneTreeiENSGT00390000005739
HOGENOMiCLU_009437_0_0_1
InParanoidiQ9Y2D4
KOiK19985
PhylomeDBiQ9Y2D4
TreeFamiTF315199

Enzyme and pathway databases

PathwayCommonsiQ9Y2D4

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...
BioGRID-ORCSi
23233, 9 hits in 871 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
EXOC6B, human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
23233
PharosiQ9Y2D4, Tdark

Protein Ontology

More...
PROi
PR:Q9Y2D4
RNActiQ9Y2D4, protein

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000144036, Expressed in corpus callosum and 220 other tissues
ExpressionAtlasiQ9Y2D4, baseline and differential
GenevisibleiQ9Y2D4, HS

Family and domain databases

Gene3Di1.10.357.30, 1 hit
InterProiView protein in InterPro
IPR007225, EXOC6/Sec15
IPR042045, EXOC6/Sec15_C_dom1
PANTHERiPTHR12702, PTHR12702, 1 hit
PfamiView protein in Pfam
PF04091, Sec15, 1 hit
PIRSFiPIRSF025007, Sec15, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiEXC6B_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9Y2D4
Secondary accession number(s): B8ZZY3
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 25, 2002
Last sequence update: April 5, 2011
Last modified: October 7, 2020
This is version 141 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families
  3. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  4. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again