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UniProtKB - Q9Y2C4 (EXOG_HUMAN)

Entry version 145 (02 Dec 2020)
Sequence version 2 (01 Jul 2008)
Previous versions | rss
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Protein

Nuclease EXOG, mitochondrial

Gene

EXOG

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Endo/exonuclease with nicking activity towards supercoiled DNA, a preference for single-stranded DNA and 5'-3' exonuclease activity.1 Publication

Miscellaneous

The active site contains 1 hydrated divalent metal cation that has only 1 direct interaction with the protein; all other interactions are via water molecules.By similarity

<p>This subsection of the 'Function' section provides information relevant to cofactors. A cofactor is any non-protein substance required for a protein to be catalytically active. Some cofactors are inorganic, such as the metal atoms zinc, iron, and copper in various oxidation states. Others, such as most vitamins, are organic.<p><a href='/help/cofactor' target='_top'>More...</a></p>Cofactori

a divalent metal cation1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei140Proton acceptor1
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section indicates at which position the protein binds a given metal ion. The nature of the metal is indicated in the 'Description' field.<p><a href='/help/metal' target='_top'>More...</a></p>Metal bindingi171Divalent metal cation; catalyticBy similarity1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionEndonuclease, Hydrolase, Nuclease
LigandMetal-binding

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		Q9Y2C4

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Nuclease EXOG, mitochondrial (EC:3.1.30.-)
Alternative name(s):
Endonuclease G-like 1
Short name:
Endo G-like 1
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:EXOG
Synonyms:ENDOGL1, ENDOGL2, ENGL
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 3

Organism-specific databases

Eukaryotic Pathogen and Host Database Resources

More...EuPathDBi		HostDB:ENSG00000157036.12

Human Gene Nomenclature Database

More...HGNCi		HGNC:3347, EXOG

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		604051, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_Q9Y2C4

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology%5Fand%5Fbiotech%5Fsection">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi137S → D: No effect on catalytic activity. 1 Publication1
Mutagenesisi140H → A: Abolishes catalytic activity. 1 Publication1

Organism-specific databases

DisGeNET

More...DisGeNETi		9941

Open Targets

More...OpenTargetsi		ENSG00000157036

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA27784

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		Q9Y2C4, Tbio

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		EXOG

Domain mapping of disease mutations (DMDM)

More...DMDMi		193806336

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a transit peptide.<p><a href='/help/transit' target='_top'>More...</a></p>Transit peptidei1 – 41MitochondrionSequence analysisAdd BLAST41
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000017866942 – 368Nuclease EXOG, mitochondrialAdd BLAST327

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		Q9Y2C4

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		Q9Y2C4

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		Q9Y2C4

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q9Y2C4

PeptideAtlas

More...PeptideAtlasi		Q9Y2C4

PRoteomics IDEntifications database

More...PRIDEi		Q9Y2C4

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		85725 [Q9Y2C4-1]
85726 [Q9Y2C4-2]
85727 [Q9Y2C4-3]
85728 [Q9Y2C4-4]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q9Y2C4

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q9Y2C4

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Ubiquitous.

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000157036, Expressed in buccal mucosa cell and 201 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		Q9Y2C4, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q9Y2C4, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000157036, Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Homodimer.

1 Publication

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		115267, 22 interactors

Protein interaction database and analysis system

More...IntActi		Q9Y2C4, 16 interactors

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000287675

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		Q9Y2C4, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1368
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q9Y2C4

Database of comparative protein structure models

More...ModBasei		Search...

Protein Data Bank in Europe - Knowledge Base

More...PDBe-KBi		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the DNA/RNA non-specific endonuclease family.Curated

Keywords - Domaini

Transit peptide

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG3721, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00940000160677

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_055174_3_0_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q9Y2C4

Identification of Orthologs from Complete Genome Data

More...OMAi		MEMYCRE

Database of Orthologous Groups

More...OrthoDBi		933605at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q9Y2C4

TreeFam database of animal gene trees

More...TreeFami		TF105386

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR001604, DNA/RNA_non-sp_Endonuclease
IPR041003, Exog_C
IPR020821, Extracellular_endonuc_su_A
IPR040255, Non-specific_endonuclease

The PANTHER Classification System

More...PANTHERi		PTHR13966, PTHR13966, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF01223, Endonuclease_NS, 1 hit
PF18026, Exog_C, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00892, Endonuclease_NS, 1 hit
SM00477, NUC, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (4+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 4 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 4 described isoforms and 8 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q9Y2C4-1) [UniParc]FASTAAdd to basket
Also known as: ENGL-a

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MAIKSIASRL RGSRRFLSGF VAGAVVGAAG AGLAALQFFR SQGAEGALTG 
        60         70         80         90        100
KQPDGSAEKA VLEQFGFPLT GTEARCYTNH ALSYDQAKRV PRWVLEHISK 
       110        120        130        140        150
SKIMGDADRK HCKFKPDPNI PPTFSAFNED YVGSGWSRGH MAPAGNNKFS 
       160        170        180        190        200
SKAMAETFYL SNIVPQDFDN NSGYWNRIEM YCRELTERFE DVWVVSGPLT 
       210        220        230        240        250
LPQTRGDGKK IVSYQVIGED NVAVPSHLYK VILARRSSVS TEPLALGAFV 
       260        270        280        290        300
VPNEAIGFQP QLTEFQVSLQ DLEKLSGLVF FPHLDRTSDI RNICSVDTCK 
       310        320        330        340        350
LLDFQEFTLY LSTRKIEGAR SVLRLEKIME NLKNAEIEPD DYFMSRYEKK 
       360 
LEELKAKEQS GTQIRKPS
Length:368
Mass (Da):41,085
Last modified:July 1, 2008 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i432E046A6F4ADF0E
GO
Isoform 2 (identifier: Q9Y2C4-2) [UniParc]FASTAAdd to basket
Also known as: ENDOGL2, ENGL-b

The sequence of this isoform differs from the canonical sequence as follows:
     1-140: Missing.
     231-289: VILARRSSVS...FFPHLDRTSD → DHAGCCVESP...RISGRIGCRV
     290-368: Missing.

Note: Probably inactive since it lacks the active site.Curated
Show »
Length:149
Mass (Da):16,571
Checksum:i119E20B841F28349
GO
Isoform 3 (identifier: Q9Y2C4-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-140: Missing.

Note: Probably inactive since it lacks the active site.Curated
Show »
Length:228
Mass (Da):26,017
Checksum:iD1490E95B8A8F5B3
GO
Isoform 4 (identifier: Q9Y2C4-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     55-104: Missing.

Show »
Length:318
Mass (Da):35,437
Checksum:i65D1A335CFAC7CA5
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 8 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H7C0W6H7C0W6_HUMAN
Nuclease EXOG, mitochondrial
EXOG
187Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F8WE28F8WE28_HUMAN
Nuclease EXOG, mitochondrial
EXOG
107Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F8WE38F8WE38_HUMAN
Nuclease EXOG, mitochondrial
EXOG
143Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F8WC11F8WC11_HUMAN
Nuclease EXOG, mitochondrial
EXOG
146Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F8WEP0F8WEP0_HUMAN
Nuclease EXOG, mitochondrial
EXOG
81Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H7C451H7C451_HUMAN
Nuclease EXOG, mitochondrial
EXOG
107Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F2Z2D3F2Z2D3_HUMAN
Nuclease EXOG, mitochondrial
EXOG
56Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0Y8P1H0Y8P1_HUMAN
Nuclease EXOG, mitochondrial
EXOG
15Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti309L → S in BAF82796 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_044320277G → V Abolishes catalytic activity. 2 PublicationsCorresponds to variant dbSNP:rs1141223Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0345061 – 140Missing in isoform 2 and isoform 3. 3 PublicationsAdd BLAST140
Alternative sequenceiVSP_04121455 – 104Missing in isoform 4. CuratedAdd BLAST50
Alternative sequenceiVSP_034507231 – 289VILAR…DRTSD → DHAGCCVESPLGTRTSEEAT ARIQERDDGGSDQRSGLVEL GIYFEGRANRISGRIGCRV in isoform 2. 1 PublicationAdd BLAST59
Alternative sequenceiVSP_034508290 – 368Missing in isoform 2. 1 PublicationAdd BLAST79

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AB020523 mRNA Translation: BAA76752.1
AB020735 mRNA Translation: BAA76753.1
AK289602 mRNA Translation: BAF82291.1
AK290107 mRNA Translation: BAF82796.1
AK301067 mRNA Translation: BAG62674.1
AK315814 mRNA Translation: BAF98705.1
CH471055 Genomic DNA Translation: EAW64538.1
BC104212 mRNA Translation: AAI04213.1
BC104213 mRNA Translation: AAI04214.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS2680.1 [Q9Y2C4-1]
CCDS46795.1 [Q9Y2C4-4]

NCBI Reference Sequences

More...RefSeqi		NP_001138936.1, NM_001145464.1 [Q9Y2C4-4]
NP_001305883.1, NM_001318954.1
NP_001305884.1, NM_001318955.1
NP_001305885.1, NM_001318956.1
NP_001305886.1, NM_001318957.1
NP_001305887.1, NM_001318958.1
NP_001305888.1, NM_001318959.1
NP_005098.2, NM_005107.3 [Q9Y2C4-1]
XP_005265690.1, XM_005265633.3
XP_006713507.1, XM_006713444.3
XP_016863073.1, XM_017007584.1 [Q9Y2C4-3]
XP_016863074.1, XM_017007585.1 [Q9Y2C4-3]
XP_016863075.1, XM_017007586.1 [Q9Y2C4-3]
XP_016863076.1, XM_017007587.1 [Q9Y2C4-3]
XP_016863077.1, XM_017007588.1 [Q9Y2C4-3]
XP_016863078.1, XM_017007589.1 [Q9Y2C4-3]
XP_016863079.1, XM_017007590.1 [Q9Y2C4-3]
XP_016863080.1, XM_017007591.1 [Q9Y2C4-3]
XP_016863081.1, XM_017007592.1 [Q9Y2C4-3]
XP_016863082.1, XM_017007593.1 [Q9Y2C4-3]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000287675; ENSP00000287675; ENSG00000157036 [Q9Y2C4-1]
ENST00000422077; ENSP00000404305; ENSG00000157036 [Q9Y2C4-4]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		9941

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:9941

UCSC genome browser

More...UCSCi		uc003cih.3, human [Q9Y2C4-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB020523 mRNA Translation: BAA76752.1
AB020735 mRNA Translation: BAA76753.1
AK289602 mRNA Translation: BAF82291.1
AK290107 mRNA Translation: BAF82796.1
AK301067 mRNA Translation: BAG62674.1
AK315814 mRNA Translation: BAF98705.1
CH471055 Genomic DNA Translation: EAW64538.1
BC104212 mRNA Translation: AAI04213.1
BC104213 mRNA Translation: AAI04214.1
CCDSiCCDS2680.1 [Q9Y2C4-1]
CCDS46795.1 [Q9Y2C4-4]
RefSeqiNP_001138936.1, NM_001145464.1 [Q9Y2C4-4]
NP_001305883.1, NM_001318954.1
NP_001305884.1, NM_001318955.1
NP_001305885.1, NM_001318956.1
NP_001305886.1, NM_001318957.1
NP_001305887.1, NM_001318958.1
NP_001305888.1, NM_001318959.1
NP_005098.2, NM_005107.3 [Q9Y2C4-1]
XP_005265690.1, XM_005265633.3
XP_006713507.1, XM_006713444.3
XP_016863073.1, XM_017007584.1 [Q9Y2C4-3]
XP_016863074.1, XM_017007585.1 [Q9Y2C4-3]
XP_016863075.1, XM_017007586.1 [Q9Y2C4-3]
XP_016863076.1, XM_017007587.1 [Q9Y2C4-3]
XP_016863077.1, XM_017007588.1 [Q9Y2C4-3]
XP_016863078.1, XM_017007589.1 [Q9Y2C4-3]
XP_016863079.1, XM_017007590.1 [Q9Y2C4-3]
XP_016863080.1, XM_017007591.1 [Q9Y2C4-3]
XP_016863081.1, XM_017007592.1 [Q9Y2C4-3]
XP_016863082.1, XM_017007593.1 [Q9Y2C4-3]

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...PDBei

Protein Data Bank RCSB

More...RCSB PDBi

Protein Data Bank Japan

More...PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4A1NX-ray2.80A42-368[»]
5T3VX-ray2.60A/B59-368[»]
5T40X-ray1.81A/B59-368[»]
5T4IX-ray2.39A/B59-368[»]
5T5CX-ray1.85A/B59-368[»]
5ZKIX-ray2.32A/B42-368[»]
5ZKJX-ray2.80A/B42-368[»]
6IIDX-ray2.99A/B/C/D42-368[»]
SMRiQ9Y2C4
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi115267, 22 interactors
IntActiQ9Y2C4, 16 interactors
STRINGi9606.ENSP00000287675

PTM databases

iPTMnetiQ9Y2C4
PhosphoSitePlusiQ9Y2C4

Polymorphism and mutation databases

BioMutaiEXOG
DMDMi193806336

Proteomic databases

EPDiQ9Y2C4
jPOSTiQ9Y2C4
MassIVEiQ9Y2C4
PaxDbiQ9Y2C4
PeptideAtlasiQ9Y2C4
PRIDEiQ9Y2C4
ProteomicsDBi85725 [Q9Y2C4-1]
85726 [Q9Y2C4-2]
85727 [Q9Y2C4-3]
85728 [Q9Y2C4-4]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		2527, 150 antibodies

Genome annotation databases

EnsembliENST00000287675; ENSP00000287675; ENSG00000157036 [Q9Y2C4-1]
ENST00000422077; ENSP00000404305; ENSG00000157036 [Q9Y2C4-4]
GeneIDi9941
KEGGihsa:9941
UCSCiuc003cih.3, human [Q9Y2C4-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		9941
DisGeNETi9941
EuPathDBiHostDB:ENSG00000157036.12

GeneCards: human genes, protein and diseases

More...GeneCardsi		EXOG
HGNCiHGNC:3347, EXOG
HPAiENSG00000157036, Low tissue specificity
MIMi604051, gene
neXtProtiNX_Q9Y2C4
OpenTargetsiENSG00000157036
PharmGKBiPA27784

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG3721, Eukaryota
GeneTreeiENSGT00940000160677
HOGENOMiCLU_055174_3_0_1
InParanoidiQ9Y2C4
OMAiMEMYCRE
OrthoDBi933605at2759
PhylomeDBiQ9Y2C4
TreeFamiTF105386

Enzyme and pathway databases

PathwayCommonsiQ9Y2C4

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		9941, 7 hits in 844 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		EXOG, human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		9941
PharosiQ9Y2C4, Tbio

Protein Ontology

More...PROi		PR:Q9Y2C4
RNActiQ9Y2C4, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000157036, Expressed in buccal mucosa cell and 201 other tissues
ExpressionAtlasiQ9Y2C4, baseline and differential
GenevisibleiQ9Y2C4, HS

Family and domain databases

InterProiView protein in InterPro
IPR001604, DNA/RNA_non-sp_Endonuclease
IPR041003, Exog_C
IPR020821, Extracellular_endonuc_su_A
IPR040255, Non-specific_endonuclease
PANTHERiPTHR13966, PTHR13966, 1 hit
PfamiView protein in Pfam
PF01223, Endonuclease_NS, 1 hit
PF18026, Exog_C, 1 hit
SMARTiView protein in SMART
SM00892, Endonuclease_NS, 1 hit
SM00477, NUC, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiEXOG_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9Y2C4
Secondary accession number(s): A8K242
, B4DVG2, Q3SXM9, Q9Y2C8
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 26, 2001
Last sequence update: July 1, 2008
Last modified: December 2, 2020
This is version 145 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Reference proteome

Documents

  1. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  2. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  5. SIMILARITY comments
    Index of protein domains and families
  6. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
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