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UniProtKB - Q9Y2C3 (B3GT5_HUMAN)
Protein
Beta-1,3-galactosyltransferase 5
Gene
B3GALT5
Organism
Homo sapiens (Human)
Status
Functioni
Catalyzes the transfer of Gal to GlcNAc-based acceptors with a preference for the core3 O-linked glycan GlcNAc(beta1,3)GalNAc structure. Can use glycolipid LC3Cer as an efficient acceptor.
2 PublicationsCatalytic activityi
- globoside Gb4Cer (d18:1(4E)) + UDP-α-D-galactose = globoside GalGb4Cer (d18:1(4E)) + H+ + UDP2 PublicationsThis reaction proceeds in the forward2 Publications direction.
: protein glycosylation Pathwayi
This protein is involved in the pathway protein glycosylation, which is part of Protein modification.View all proteins of this organism that are known to be involved in the pathway protein glycosylation and in Protein modification.
GO - Molecular functioni
- glycosyltransferase activity Source: GO_Central
- UDP-galactose:beta-N-acetylglucosamine beta-1,3-galactosyltransferase activity Source: GO_Central
- UDP-glycosyltransferase activity Source: GO_Central
GO - Biological processi
- lipid metabolic process Source: UniProtKB-KW
- oligosaccharide biosynthetic process Source: Reactome
- protein glycosylation Source: ProtInc
Keywordsi
Molecular function | Glycosyltransferase, Transferase |
Biological process | Lipid metabolism |
Enzyme and pathway databases
PathwayCommonsi | Q9Y2C3 |
Reactomei | R-HSA-9037629, Lewis blood group biosynthesis |
SignaLinki | Q9Y2C3 |
UniPathwayi | UPA00378 |
Protein family/group databases
CAZyi | GT31, Glycosyltransferase Family 31 |
Chemistry databases
SwissLipidsi | SLP:000000792 SLP:000000844 |
Names & Taxonomyi
Protein namesi | Recommended name: Beta-1,3-galactosyltransferase 5Curated (EC:2.4.1.-2 Publications)Short name: Beta-1,3-GalTase 5 Short name: Beta3Gal-T5 Short name: Beta3GalT5 Short name: b3Gal-T5 Alternative name(s): Beta-3-Gx-T5 UDP-Gal:beta-GlcNAc beta-1,3-galactosyltransferase 5 UDP-galactose:beta-N-acetylglucosamine beta-1,3-galactosyltransferase 5 |
Gene namesi | Name:B3GALT5Imported |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:920, B3GALT5 |
MIMi | 604066, gene |
neXtProti | NX_Q9Y2C3 |
VEuPathDBi | HostDB:ENSG00000183778 |
Subcellular locationi
Golgi apparatus
- Golgi apparatus membrane Curated; Single-pass type II membrane protein Curated
Endoplasmic reticulum
- endoplasmic reticulum Source: UniProtKB
Golgi apparatus
- Golgi apparatus Source: UniProtKB
- Golgi membrane Source: GO_Central
Other locations
- integral component of membrane Source: UniProtKB-KW
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 1 – 7 | CytoplasmicSequence analysis | 7 | |
Transmembranei | 8 – 28 | Helical; Signal-anchor for type II membrane proteinSequence analysisAdd BLAST | 21 | |
Topological domaini | 29 – 310 | LumenalSequence analysisAdd BLAST | 282 |
Keywords - Cellular componenti
Golgi apparatus, MembranePathology & Biotechi
Organism-specific databases
DisGeNETi | 10317 |
OpenTargetsi | ENSG00000183778 |
PharmGKBi | PA25213 |
Miscellaneous databases
Pharosi | Q9Y2C3, Tbio |
Chemistry databases
ChEMBLi | CHEMBL2321635 |
Genetic variation databases
BioMutai | B3GALT5 |
DMDMi | 13123995 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000219164 | 1 – 310 | Beta-1,3-galactosyltransferase 5Add BLAST | 310 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Glycosylationi | 130 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 174 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 231 | N-linked (GlcNAc...) asparagineSequence analysis | 1 |
Keywords - PTMi
GlycoproteinProteomic databases
EPDi | Q9Y2C3 |
jPOSTi | Q9Y2C3 |
MassIVEi | Q9Y2C3 |
PaxDbi | Q9Y2C3 |
PeptideAtlasi | Q9Y2C3 |
PRIDEi | Q9Y2C3 |
ProteomicsDBi | 85724 |
PTM databases
GlyGeni | Q9Y2C3, 3 sites |
iPTMneti | Q9Y2C3 |
PhosphoSitePlusi | Q9Y2C3 |
Expressioni
Tissue specificityi
Expressed in stomach, jejunum, colon, pancreas, small intestine, testis and gastrointestinal and pancreatic cancer cell lines. Hardly detected in lung, liver, adrenal gland and peripheral blood leukocytes.1 Publication
Gene expression databases
Bgeei | ENSG00000183778, Expressed in palpebral conjunctiva and 130 other tissues |
ExpressionAtlasi | Q9Y2C3, baseline and differential |
Genevisiblei | Q9Y2C3, HS |
Organism-specific databases
HPAi | ENSG00000183778, Tissue enriched (intestine) |
Interactioni
Binary interactionsi
Q9Y2C3
With | #Exp. | IntAct |
---|---|---|
CLEC2D - isoform 2 [Q9UHP7-3] | 3 | EBI-14141066,EBI-11749983 |
DEFB103B [P81534] | 3 | EBI-14141066,EBI-12074168 |
Protein-protein interaction databases
BioGRIDi | 115601, 25 interactors |
IntActi | Q9Y2C3, 2 interactors |
STRINGi | 9606.ENSP00000381699 |
Miscellaneous databases
RNActi | Q9Y2C3, protein |
Family & Domainsi
Sequence similaritiesi
Belongs to the glycosyltransferase 31 family.Curated
Keywords - Domaini
Signal-anchor, Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG2287, Eukaryota |
GeneTreei | ENSGT00940000160964 |
HOGENOMi | CLU_036849_2_4_1 |
InParanoidi | Q9Y2C3 |
OMAi | HSQQTFF |
OrthoDBi | 1037602at2759 |
PhylomeDBi | Q9Y2C3 |
TreeFami | TF318639 |
Family and domain databases
InterProi | View protein in InterPro IPR002659, Glyco_trans_31 |
PANTHERi | PTHR11214, PTHR11214, 1 hit |
Pfami | View protein in Pfam PF01762, Galactosyl_T, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All
Q9Y2C3-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MAFPKMRLMY ICLLVLGALC LYFSMYSLNP FKEQSFVYKK DGNFLKLPDT
60 70 80 90 100
DCRQTPPFLV LLVTSSHKQL AERMAIRQTW GKERMVKGKQ LKTFFLLGTT
110 120 130 140 150
SSAAETKEVD QESQRHGDII QKDFLDVYYN LTLKTMMGIE WVHRFCPQAA
160 170 180 190 200
FVMKTDSDMF INVDYLTELL LKKNRTTRFF TGFLKLNEFP IRQPFSKWFV
210 220 230 240 250
SKSEYPWDRY PPFCSGTGYV FSGDVASQVY NVSKSVPYIK LEDVFVGLCL
260 270 280 290 300
ERLNIRLEEL HSQPTFFPGG LRFSVCLFRR IVACHFIKPR TLLDYWQALE
310
NSRGEDCPPV
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketA0A0A0MS93 | A0A0A0MS93_HUMAN | Hexosyltransferase | B3GALT5 | 314 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 23 | F → Y in CAB91547 (Ref. 3) Curated | 1 | |
Sequence conflicti | 26 | Y → N in CAB91547 (Ref. 3) Curated | 1 | |
Sequence conflicti | 293 – 297 | LDYWQ → WTTGR in BAA94498 (Ref. 9) Curated | 5 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_049347 | 27 | S → R. Corresponds to variant dbSNP:rs12627708Ensembl. | 1 | |
Natural variantiVAR_020460 | 85 | M → T5 PublicationsCorresponds to variant dbSNP:rs3746887Ensembl. | 1 | |
Natural variantiVAR_033536 | 144 | R → H. Corresponds to variant dbSNP:rs734411Ensembl. | 1 |
Sequence databases
Genome annotation databases
Similar proteinsi
Cross-referencesi
Web resourcesi
Functional Glycomics Gateway - GTase Beta-1,3-galactosyltransferase 5 |
Sequence databases
3D structure databases
SMRi | Q9Y2C3 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 115601, 25 interactors |
IntActi | Q9Y2C3, 2 interactors |
STRINGi | 9606.ENSP00000381699 |
Chemistry databases
ChEMBLi | CHEMBL2321635 |
SwissLipidsi | SLP:000000792 SLP:000000844 |
Protein family/group databases
CAZyi | GT31, Glycosyltransferase Family 31 |
PTM databases
GlyGeni | Q9Y2C3, 3 sites |
iPTMneti | Q9Y2C3 |
PhosphoSitePlusi | Q9Y2C3 |
Genetic variation databases
BioMutai | B3GALT5 |
DMDMi | 13123995 |
Proteomic databases
EPDi | Q9Y2C3 |
jPOSTi | Q9Y2C3 |
MassIVEi | Q9Y2C3 |
PaxDbi | Q9Y2C3 |
PeptideAtlasi | Q9Y2C3 |
PRIDEi | Q9Y2C3 |
ProteomicsDBi | 85724 |
Protocols and materials databases
Antibodypediai | 23457, 108 antibodies from 24 providers |
DNASUi | 10317 |
Genome annotation databases
Organism-specific databases
CTDi | 10317 |
DisGeNETi | 10317 |
GeneCardsi | B3GALT5 |
HGNCi | HGNC:920, B3GALT5 |
HPAi | ENSG00000183778, Tissue enriched (intestine) |
MIMi | 604066, gene |
neXtProti | NX_Q9Y2C3 |
OpenTargetsi | ENSG00000183778 |
PharmGKBi | PA25213 |
VEuPathDBi | HostDB:ENSG00000183778 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG2287, Eukaryota |
GeneTreei | ENSGT00940000160964 |
HOGENOMi | CLU_036849_2_4_1 |
InParanoidi | Q9Y2C3 |
OMAi | HSQQTFF |
OrthoDBi | 1037602at2759 |
PhylomeDBi | Q9Y2C3 |
TreeFami | TF318639 |
Enzyme and pathway databases
UniPathwayi | UPA00378 |
PathwayCommonsi | Q9Y2C3 |
Reactomei | R-HSA-9037629, Lewis blood group biosynthesis |
SignaLinki | Q9Y2C3 |
Miscellaneous databases
BioGRID-ORCSi | 10317, 10 hits in 1034 CRISPR screens |
ChiTaRSi | B3GALT5, human |
GeneWikii | B3GALT5 |
GenomeRNAii | 10317 |
Pharosi | Q9Y2C3, Tbio |
PROi | PR:Q9Y2C3 |
RNActi | Q9Y2C3, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000183778, Expressed in palpebral conjunctiva and 130 other tissues |
ExpressionAtlasi | Q9Y2C3, baseline and differential |
Genevisiblei | Q9Y2C3, HS |
Family and domain databases
InterProi | View protein in InterPro IPR002659, Glyco_trans_31 |
PANTHERi | PTHR11214, PTHR11214, 1 hit |
Pfami | View protein in Pfam PF01762, Galactosyl_T, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | B3GT5_HUMAN | |
Accessioni | Q9Y2C3Primary (citable) accession number: Q9Y2C3 Secondary accession number(s): A8KA86 Q9P1X7 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | February 21, 2001 |
Last sequence update: | November 1, 1999 | |
Last modified: | February 23, 2022 | |
This is version 163 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human chromosome 21
Human chromosome 21: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PATHWAY comments
Index of metabolic and biosynthesis pathways - SIMILARITY comments
Index of protein domains and families