B3GALT5

Functionⁱ

Catalyzes the transfer of Gal to GlcNAc-based acceptors with a preference for the core3 O-linked glycan GlcNAc(beta1,3)GalNAc structure. Can use glycolipid LC3Cer as an efficient acceptor.

Pathwayⁱ: protein glycosylation

This protein is involved in the pathway protein glycosylation, which is part of Protein modification.
View all proteins of this organism that are known to be involved in the pathway protein glycosylation and in Protein modification.

GO - Molecular functionⁱ

UDP-galactose:beta-N-acetylglucosamine beta-1,3-galactosyltransferase activity
Source: ProtInc
Traceable author statementⁱ
- 10212226

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

protein glycosylation
Source: ProtInc
Traceable author statementⁱ
- 10212226

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Glycosyltransferase, Transferase

Molecular function

Glycosyltransferase, Transferase

Enzyme and pathway databases

BioCycⁱ	MetaCyc:MONOMER-20081
UniPathwayⁱ	UPA00378

Protein family/group databases

Carbohydrate-Active enZymes More...CAZyⁱ	GT31 Glycosyltransferase Family 31

CAZyⁱ

GT31 Glycosyltransferase Family 31

Chemistry databases

SwissLipidsⁱ	SLP:000000792 SLP:000000844

SwissLipidsⁱ

SLP:000000792
SLP:000000844

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Beta-1,3-galactosyltransferase 5 (EC:2.4.1.-) Short name: Beta-1,3-GalTase 5 Short name: Beta3Gal-T5 Short name: Beta3GalT5 Short name: b3Gal-T5 Alternative name(s): Beta-3-Gx-T5 UDP-Gal:beta-GlcNAc beta-1,3-galactosyltransferase 5 UDP-galactose:beta-N-acetylglucosamine beta-1,3-galactosyltransferase 5
Gene namesⁱ	Name:B3GALT5
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 21

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000183778.17
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:920 B3GALT5
MIMⁱ	604066 gene
neXtProtⁱ	NX_Q9Y2C3

Topology

Feature key	Position(s)	DescriptionActions	Length
Topological domainⁱ	1 – 7	CytoplasmicSequence analysis	7
Transmembraneⁱ	8 – 28	Helical; Signal-anchor for type II membrane proteinSequence analysisAdd BLAST	21
Topological domainⁱ	29 – 310	LumenalSequence analysisAdd BLAST	282

Keywords - Cellular componentⁱ

Golgi apparatus, Membrane

Pathology & Biotechⁱ

Organism-specific databases

DisGeNET More...DisGeNETⁱ	10317
Open Targets More...OpenTargetsⁱ	ENSG00000183778
PharmGKBⁱ	PA25213

Chemistry databases

ChEMBLⁱ

CHEMBL2321635

Polymorphism and mutation databases

BioMutaⁱ	B3GALT5
DMDMⁱ	13123995

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000219164	1 – 310	Beta-1,3-galactosyltransferase 5Add BLAST		310

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Glycosylationⁱ	130	N-linked (GlcNAc...) asparagineSequence analysis	1
Glycosylationⁱ	174	N-linked (GlcNAc...) asparagineSequence analysis	1
Glycosylationⁱ	231	N-linked (GlcNAc...) asparagineSequence analysis	1

Keywords - PTMⁱ

Glycoprotein

Proteomic databases

PaxDbⁱ	Q9Y2C3
PeptideAtlas More...PeptideAtlasⁱ	Q9Y2C3
PRIDEⁱ	Q9Y2C3
ProteomicsDBⁱ	85724

PTM databases

iPTMnetⁱ	Q9Y2C3
PhosphoSitePlusⁱ	Q9Y2C3

Expressionⁱ

Tissue specificityⁱ

Expressed in stomach, jejunum, colon, pancreas, small intestine, testis and gastrointestinal and pancreatic cancer cell lines. Hardly detected in lung, liver, adrenal gland and peripheral blood leukocytes.

Gene expression databases

Bgeeⁱ	ENSG00000183778 Expressed in 112 organ(s), highest expression level in palpebral conjunctiva
CleanExⁱ	HS_B3GALT5
ExpressionAtlasⁱ	Q9Y2C3 baseline and differential
Genevisibleⁱ	Q9Y2C3 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA054092 HPA054684

HPAⁱ

HPA054092
HPA054684

Interactionⁱ

Protein-protein interaction databases

BioGridⁱ	115601, 21 interactors
IntActⁱ	Q9Y2C3, 2 interactors
STRINGⁱ	9606.ENSP00000343318

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q9Y2C3
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Sequence similaritiesⁱ

Belongs to the glycosyltransferase 31 family.Curated

Keywords - Domainⁱ

Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGⁱ	KOG2287 Eukaryota ENOG410ZZ1B LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00760000118879
HOVERGENⁱ	HBG094868
InParanoidⁱ	Q9Y2C3
KEGG Orthology (KO) More...KOⁱ	K03877
PhylomeDBⁱ	Q9Y2C3
TreeFamⁱ	TF318639

Family and domain databases

InterProⁱ	View protein in InterPro IPR002659 Glyco_trans_31
PANTHERⁱ	PTHR11214 PTHR11214, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF01762 Galactosyl_T, 1 hit

Sequence (1+)ⁱ

Sequence statusⁱ: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.ⁱShow all

Q9Y2C3-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MAFPKMRLMY ICLLVLGALC LYFSMYSLNP FKEQSFVYKK DGNFLKLPDT 
        60         70         80         90        100
DCRQTPPFLV LLVTSSHKQL AERMAIRQTW GKERMVKGKQ LKTFFLLGTT 
       110        120        130        140        150
SSAAETKEVD QESQRHGDII QKDFLDVYYN LTLKTMMGIE WVHRFCPQAA 
       160        170        180        190        200
FVMKTDSDMF INVDYLTELL LKKNRTTRFF TGFLKLNEFP IRQPFSKWFV 
       210        220        230        240        250
SKSEYPWDRY PPFCSGTGYV FSGDVASQVY NVSKSVPYIK LEDVFVGLCL 
       260        270        280        290        300
ERLNIRLEEL HSQPTFFPGG LRFSVCLFRR IVACHFIKPR TLLDYWQALE 
       310
NSRGEDCPPV

Length:310

Mass (Da):36,189

Last modified:November 1, 1999 - v1

Checksum:ⁱ4DD7A19E3E648AA9

GO

Computationally mapped potential isoform sequencesⁱ

There is 1 potential isoform mapped to this entry.BLAST Align Show all Add to basket

	Entry	Entry name		Protein names	Gene names	Length	Annotation
	A0A0A0MS93	A0A0A0MS93_HUMAN		Hexosyltransferase Hexosyltransferase, EC 2.4.1.-	B3GALT5	314	Annotation score:

Experimental Info

Feature key	Position(s)	DescriptionActions	Length
Sequence conflictⁱ	23	F → Y in CAB91547 (Ref. 3) Curated	1
Sequence conflictⁱ	26	Y → N in CAB91547 (Ref. 3) Curated	1
Sequence conflictⁱ	293 – 297	LDYWQ → WTTGR in BAA94498 (Ref. 9) Curated	5

Natural variant

Feature key	Position(s)	DescriptionActions	Length
Natural variantⁱVAR_049347	27	S → R. Corresponds to variant dbSNP:rs12627708Ensembl.	1
Natural variantⁱVAR_020460	85	M → T5 PublicationsCorresponds to variant dbSNP:rs3746887Ensembl.	1
Natural variantⁱVAR_033536	144	R → H. Corresponds to variant dbSNP:rs734411Ensembl.	1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AB020337 mRNA Translation: BAA77664.1 AF145784 Genomic DNA Translation: AAF07880.1 AJ006078 Genomic DNA Translation: CAB91547.1 AY372061 mRNA Translation: AAR08910.1 AK292951 mRNA Translation: BAF85640.1 AL163280 Genomic DNA Translation: CAB90446.1 CH471079 Genomic DNA Translation: EAX09629.1 CH471079 Genomic DNA Translation: EAX09630.1 CH471079 Genomic DNA Translation: EAX09631.1 CH471079 Genomic DNA Translation: EAX09632.1 BC104862 mRNA Translation: AAI04863.1 BC104864 mRNA Translation: AAI04865.1 AB041413 Genomic DNA Translation: BAA94498.1 AB041416 Genomic DNA Translation: BAA94501.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS13667.1
NCBI Reference Sequences More...RefSeqⁱ	NP_001265579.1, NM_001278650.1 NP_006048.1, NM_006057.2 NP_149360.1, NM_033170.2 NP_149361.1, NM_033171.2 NP_149362.2, NM_033172.2 XP_016883716.1, XM_017028227.1 XP_016883717.1, XM_017028228.1 XP_016883718.1, XM_017028229.1 XP_016883719.1, XM_017028230.1 XP_016883720.1, XM_017028231.1 XP_016883721.1, XM_017028232.1 XP_016883722.1, XM_017028233.1 XP_016883723.1, XM_017028234.1 XP_016883724.1, XM_017028235.1 XP_016883725.1, XM_017028236.1 XP_016883726.1, XM_017028237.1 XP_016883727.1, XM_017028238.1 XP_016883728.1, XM_017028239.1 XP_016883729.1, XM_017028240.1 XP_016883730.1, XM_017028241.1
UniGeneⁱ	Hs.733638

Genome annotation databases

Ensemblⁱ	ENST00000343118; ENSP00000343318; ENSG00000183778 ENST00000380618; ENSP00000369992; ENSG00000183778 ENST00000380620; ENSP00000369994; ENSG00000183778 ENST00000615480; ENSP00000480285; ENSG00000183778
GeneIDⁱ	10317
KEGGⁱ	hsa:10317
UCSC genome browser More...UCSCⁱ	uc002yyb.3 human

Keywords - Coding sequence diversityⁱ

Polymorphism

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
Q9Y2C3	Hexosyltransferase		HUMAN		314	UniRef100_Q9Y2C3

Protein	Similar proteins		Species	Score	Length	Source
Q9Y2C3	Beta-1,3-galactosyltransferase 5 (Fragment)		PANPA		301	UniRef90_Q9Y2C3
Beta-1,3-galactosyltransferase 5 (Fragment)		GORGO		298
Beta-1,3-galactosyltransferase 5 (Fragment)		PANTR		297
Hexosyltransferase		HUMAN		314
Hexosyltransferase		MACMU		315
+34

Protein	Similar proteins		Species	Score	Length	Source
Q9Y2C3	Beta-1,3-galactosyltransferase 5 (Fragment)		PANPA		301	UniRef50_Q9Y2C3
Beta-1,3-galactosyltransferase 5 (Fragment)		GORGO		298
Beta-1,3-galactosyltransferase 5 (Fragment)		PANTR		297
Beta-1,3-galactosyltransferase 5		MOUSE		308
Hexosyltransferase		HUMAN		314
+187

Cross-referencesⁱ

Web resourcesⁱ

Functional Glycomics Gateway - GTase

Beta-1,3-galactosyltransferase 5

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AB020337 mRNA Translation: BAA77664.1 AF145784 Genomic DNA Translation: AAF07880.1 AJ006078 Genomic DNA Translation: CAB91547.1 AY372061 mRNA Translation: AAR08910.1 AK292951 mRNA Translation: BAF85640.1 AL163280 Genomic DNA Translation: CAB90446.1 CH471079 Genomic DNA Translation: EAX09629.1 CH471079 Genomic DNA Translation: EAX09630.1 CH471079 Genomic DNA Translation: EAX09631.1 CH471079 Genomic DNA Translation: EAX09632.1 BC104862 mRNA Translation: AAI04863.1 BC104864 mRNA Translation: AAI04865.1 AB041413 Genomic DNA Translation: BAA94498.1 AB041416 Genomic DNA Translation: BAA94501.1
CCDSⁱ	CCDS13667.1
RefSeqⁱ	NP_001265579.1, NM_001278650.1 NP_006048.1, NM_006057.2 NP_149360.1, NM_033170.2 NP_149361.1, NM_033171.2 NP_149362.2, NM_033172.2 XP_016883716.1, XM_017028227.1 XP_016883717.1, XM_017028228.1 XP_016883718.1, XM_017028229.1 XP_016883719.1, XM_017028230.1 XP_016883720.1, XM_017028231.1 XP_016883721.1, XM_017028232.1 XP_016883722.1, XM_017028233.1 XP_016883723.1, XM_017028234.1 XP_016883724.1, XM_017028235.1 XP_016883725.1, XM_017028236.1 XP_016883726.1, XM_017028237.1 XP_016883727.1, XM_017028238.1 XP_016883728.1, XM_017028239.1 XP_016883729.1, XM_017028240.1 XP_016883730.1, XM_017028241.1
UniGeneⁱ	Hs.733638

3D structure databases

ProteinModelPortalⁱ	Q9Y2C3
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	115601, 21 interactors
IntActⁱ	Q9Y2C3, 2 interactors
STRINGⁱ	9606.ENSP00000343318

Chemistry databases

ChEMBLⁱ	CHEMBL2321635
SwissLipidsⁱ	SLP:000000792 SLP:000000844

Protein family/group databases

CAZyⁱ	GT31 Glycosyltransferase Family 31

CAZyⁱ

GT31 Glycosyltransferase Family 31

PTM databases

iPTMnetⁱ	Q9Y2C3
PhosphoSitePlusⁱ	Q9Y2C3

Polymorphism and mutation databases

BioMutaⁱ	B3GALT5
DMDMⁱ	13123995

Proteomic databases

PaxDbⁱ	Q9Y2C3
PeptideAtlasⁱ	Q9Y2C3
PRIDEⁱ	Q9Y2C3
ProteomicsDBⁱ	85724

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	10317
Structural Biology Knowledgebase	Search...

Genome annotation databases

Ensemblⁱ	ENST00000343118; ENSP00000343318; ENSG00000183778 ENST00000380618; ENSP00000369992; ENSG00000183778 ENST00000380620; ENSP00000369994; ENSG00000183778 ENST00000615480; ENSP00000480285; ENSG00000183778
GeneIDⁱ	10317
KEGGⁱ	hsa:10317
UCSCⁱ	uc002yyb.3 human

Organism-specific databases

CTDⁱ	10317
DisGeNETⁱ	10317
EuPathDBⁱ	HostDB:ENSG00000183778.17
GeneCardsⁱ	B3GALT5
HGNCⁱ	HGNC:920 B3GALT5
HPAⁱ	HPA054092 HPA054684
MIMⁱ	604066 gene
neXtProtⁱ	NX_Q9Y2C3
OpenTargetsⁱ	ENSG00000183778
PharmGKBⁱ	PA25213
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG2287 Eukaryota ENOG410ZZ1B LUCA
GeneTreeⁱ	ENSGT00760000118879
HOVERGENⁱ	HBG094868
InParanoidⁱ	Q9Y2C3
KOⁱ	K03877
PhylomeDBⁱ	Q9Y2C3
TreeFamⁱ	TF318639

Enzyme and pathway databases

UniPathwayⁱ	UPA00378
BioCycⁱ	MetaCyc:MONOMER-20081

Miscellaneous databases

ChiTaRSⁱ	B3GALT5 human
GeneWikiⁱ	B3GALT5
GenomeRNAiⁱ	10317
Protein Ontology More...PROⁱ	PR:Q9Y2C3
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000183778 Expressed in 112 organ(s), highest expression level in palpebral conjunctiva
CleanExⁱ	HS_B3GALT5
ExpressionAtlasⁱ	Q9Y2C3 baseline and differential
Genevisibleⁱ	Q9Y2C3 HS

Family and domain databases

InterProⁱ	View protein in InterPro IPR002659 Glyco_trans_31
PANTHERⁱ	PTHR11214 PTHR11214, 1 hit
Pfamⁱ	View protein in Pfam PF01762 Galactosyl_T, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	B3GT5_HUMAN
Accessionⁱ	Q9Y2C3Primary (citable) accession number: Q9Y2C3 Secondary accession number(s): A8KA86 Q9P1X7
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	February 21, 2001
	Last sequence update:	November 1, 1999
	Last modified:	September 12, 2018
	This is version 141 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - Q9Y2C3 (B3GT5_HUMAN)

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Beta-1,3-galactosyltransferase 5

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section describes the metabolic pathway(s) associated with a protein.<p><a href='/help/pathway' target='_top'>More...</a></p>Pathwayi: protein glycosylation

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

Protein family/group databases

Chemistry databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Golgi apparatus

Endoplasmic reticulum

Golgi apparatus

Other locations

Topology

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Chemistry databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Phylogenomic databases

Family and domain databases

Computationally mapped potential isoform sequencesi

Experimental Info

Natural variant

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross_references_section">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

Sequence databases

3D structure databases

Protein-protein interaction databases

Chemistry databases

Protein family/group databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

UniProt is an ELIXIR core data resource

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Functionⁱ

Pathwayⁱ: protein glycosylation

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Computationally mapped potential isoform sequencesⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Web resourcesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ