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Protein

Beta-1,3-galactosyltransferase 5

Gene

B3GALT5

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Catalyzes the transfer of Gal to GlcNAc-based acceptors with a preference for the core3 O-linked glycan GlcNAc(beta1,3)GalNAc structure. Can use glycolipid LC3Cer as an efficient acceptor.

Pathwayi: protein glycosylation

This protein is involved in the pathway protein glycosylation, which is part of Protein modification.
View all proteins of this organism that are known to be involved in the pathway protein glycosylation and in Protein modification.

GO - Molecular functioni

  • UDP-galactose:beta-N-acetylglucosamine beta-1,3-galactosyltransferase activity Source: ProtInc

GO - Biological processi

Keywordsi

Molecular functionGlycosyltransferase, Transferase

Enzyme and pathway databases

BioCyciMetaCyc:MONOMER-20081
UniPathwayi
UPA00378

Protein family/group databases

CAZyiGT31 Glycosyltransferase Family 31

Chemistry databases

SwissLipidsiSLP:000000792
SLP:000000844

Names & Taxonomyi

Protein namesi
Recommended name:
Beta-1,3-galactosyltransferase 5 (EC:2.4.1.-)
Short name:
Beta-1,3-GalTase 5
Short name:
Beta3Gal-T5
Short name:
Beta3GalT5
Short name:
b3Gal-T5
Alternative name(s):
Beta-3-Gx-T5
UDP-Gal:beta-GlcNAc beta-1,3-galactosyltransferase 5
UDP-galactose:beta-N-acetylglucosamine beta-1,3-galactosyltransferase 5
Gene namesi
Name:B3GALT5
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 21

Organism-specific databases

EuPathDBiHostDB:ENSG00000183778.17
HGNCiHGNC:920 B3GALT5
MIMi604066 gene
neXtProtiNX_Q9Y2C3

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 7CytoplasmicSequence analysis7
Transmembranei8 – 28Helical; Signal-anchor for type II membrane proteinSequence analysisAdd BLAST21
Topological domaini29 – 310LumenalSequence analysisAdd BLAST282

Keywords - Cellular componenti

Golgi apparatus, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi10317
OpenTargetsiENSG00000183778
PharmGKBiPA25213

Chemistry databases

ChEMBLiCHEMBL2321635

Polymorphism and mutation databases

BioMutaiB3GALT5
DMDMi13123995

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002191641 – 310Beta-1,3-galactosyltransferase 5Add BLAST310

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi130N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi174N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi231N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ9Y2C3
PeptideAtlasiQ9Y2C3
PRIDEiQ9Y2C3
ProteomicsDBi85724

PTM databases

iPTMnetiQ9Y2C3
PhosphoSitePlusiQ9Y2C3

Expressioni

Tissue specificityi

Expressed in stomach, jejunum, colon, pancreas, small intestine, testis and gastrointestinal and pancreatic cancer cell lines. Hardly detected in lung, liver, adrenal gland and peripheral blood leukocytes.

Gene expression databases

BgeeiENSG00000183778 Expressed in 112 organ(s), highest expression level in palpebral conjunctiva
CleanExiHS_B3GALT5
ExpressionAtlasiQ9Y2C3 baseline and differential
GenevisibleiQ9Y2C3 HS

Organism-specific databases

HPAiHPA054092
HPA054684

Interactioni

Protein-protein interaction databases

BioGridi115601, 21 interactors
IntActiQ9Y2C3, 2 interactors
STRINGi9606.ENSP00000343318

Structurei

3D structure databases

ProteinModelPortaliQ9Y2C3
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the glycosyltransferase 31 family.Curated

Keywords - Domaini

Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG2287 Eukaryota
ENOG410ZZ1B LUCA
GeneTreeiENSGT00760000118879
HOVERGENiHBG094868
InParanoidiQ9Y2C3
KOiK03877
PhylomeDBiQ9Y2C3
TreeFamiTF318639

Family and domain databases

InterProiView protein in InterPro
IPR002659 Glyco_trans_31
PANTHERiPTHR11214 PTHR11214, 1 hit
PfamiView protein in Pfam
PF01762 Galactosyl_T, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.iShow all

Q9Y2C3-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAFPKMRLMY ICLLVLGALC LYFSMYSLNP FKEQSFVYKK DGNFLKLPDT
60 70 80 90 100
DCRQTPPFLV LLVTSSHKQL AERMAIRQTW GKERMVKGKQ LKTFFLLGTT
110 120 130 140 150
SSAAETKEVD QESQRHGDII QKDFLDVYYN LTLKTMMGIE WVHRFCPQAA
160 170 180 190 200
FVMKTDSDMF INVDYLTELL LKKNRTTRFF TGFLKLNEFP IRQPFSKWFV
210 220 230 240 250
SKSEYPWDRY PPFCSGTGYV FSGDVASQVY NVSKSVPYIK LEDVFVGLCL
260 270 280 290 300
ERLNIRLEEL HSQPTFFPGG LRFSVCLFRR IVACHFIKPR TLLDYWQALE
310
NSRGEDCPPV
Length:310
Mass (Da):36,189
Last modified:November 1, 1999 - v1
Checksum:i4DD7A19E3E648AA9
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A0A0MS93A0A0A0MS93_HUMAN
Hexosyltransferase
B3GALT5
314Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti23F → Y in CAB91547 (Ref. 3) Curated1
Sequence conflicti26Y → N in CAB91547 (Ref. 3) Curated1
Sequence conflicti293 – 297LDYWQ → WTTGR in BAA94498 (Ref. 9) Curated5

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_04934727S → R. Corresponds to variant dbSNP:rs12627708Ensembl.1
Natural variantiVAR_02046085M → T5 PublicationsCorresponds to variant dbSNP:rs3746887Ensembl.1
Natural variantiVAR_033536144R → H. Corresponds to variant dbSNP:rs734411Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB020337 mRNA Translation: BAA77664.1
AF145784 Genomic DNA Translation: AAF07880.1
AJ006078 Genomic DNA Translation: CAB91547.1
AY372061 mRNA Translation: AAR08910.1
AK292951 mRNA Translation: BAF85640.1
AL163280 Genomic DNA Translation: CAB90446.1
CH471079 Genomic DNA Translation: EAX09629.1
CH471079 Genomic DNA Translation: EAX09630.1
CH471079 Genomic DNA Translation: EAX09631.1
CH471079 Genomic DNA Translation: EAX09632.1
BC104862 mRNA Translation: AAI04863.1
BC104864 mRNA Translation: AAI04865.1
AB041413 Genomic DNA Translation: BAA94498.1
AB041416 Genomic DNA Translation: BAA94501.1
CCDSiCCDS13667.1
RefSeqiNP_001265579.1, NM_001278650.1
NP_006048.1, NM_006057.2
NP_149360.1, NM_033170.2
NP_149361.1, NM_033171.2
NP_149362.2, NM_033172.2
XP_016883716.1, XM_017028227.1
XP_016883717.1, XM_017028228.1
XP_016883718.1, XM_017028229.1
XP_016883719.1, XM_017028230.1
XP_016883720.1, XM_017028231.1
XP_016883721.1, XM_017028232.1
XP_016883722.1, XM_017028233.1
XP_016883723.1, XM_017028234.1
XP_016883724.1, XM_017028235.1
XP_016883725.1, XM_017028236.1
XP_016883726.1, XM_017028237.1
XP_016883727.1, XM_017028238.1
XP_016883728.1, XM_017028239.1
XP_016883729.1, XM_017028240.1
XP_016883730.1, XM_017028241.1
UniGeneiHs.733638

Genome annotation databases

EnsembliENST00000343118; ENSP00000343318; ENSG00000183778
ENST00000380618; ENSP00000369992; ENSG00000183778
ENST00000380620; ENSP00000369994; ENSG00000183778
ENST00000615480; ENSP00000480285; ENSG00000183778
GeneIDi10317
KEGGihsa:10317
UCSCiuc002yyb.3 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Cross-referencesi

Web resourcesi

Functional Glycomics Gateway - GTase

Beta-1,3-galactosyltransferase 5

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB020337 mRNA Translation: BAA77664.1
AF145784 Genomic DNA Translation: AAF07880.1
AJ006078 Genomic DNA Translation: CAB91547.1
AY372061 mRNA Translation: AAR08910.1
AK292951 mRNA Translation: BAF85640.1
AL163280 Genomic DNA Translation: CAB90446.1
CH471079 Genomic DNA Translation: EAX09629.1
CH471079 Genomic DNA Translation: EAX09630.1
CH471079 Genomic DNA Translation: EAX09631.1
CH471079 Genomic DNA Translation: EAX09632.1
BC104862 mRNA Translation: AAI04863.1
BC104864 mRNA Translation: AAI04865.1
AB041413 Genomic DNA Translation: BAA94498.1
AB041416 Genomic DNA Translation: BAA94501.1
CCDSiCCDS13667.1
RefSeqiNP_001265579.1, NM_001278650.1
NP_006048.1, NM_006057.2
NP_149360.1, NM_033170.2
NP_149361.1, NM_033171.2
NP_149362.2, NM_033172.2
XP_016883716.1, XM_017028227.1
XP_016883717.1, XM_017028228.1
XP_016883718.1, XM_017028229.1
XP_016883719.1, XM_017028230.1
XP_016883720.1, XM_017028231.1
XP_016883721.1, XM_017028232.1
XP_016883722.1, XM_017028233.1
XP_016883723.1, XM_017028234.1
XP_016883724.1, XM_017028235.1
XP_016883725.1, XM_017028236.1
XP_016883726.1, XM_017028237.1
XP_016883727.1, XM_017028238.1
XP_016883728.1, XM_017028239.1
XP_016883729.1, XM_017028240.1
XP_016883730.1, XM_017028241.1
UniGeneiHs.733638

3D structure databases

ProteinModelPortaliQ9Y2C3
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi115601, 21 interactors
IntActiQ9Y2C3, 2 interactors
STRINGi9606.ENSP00000343318

Chemistry databases

ChEMBLiCHEMBL2321635
SwissLipidsiSLP:000000792
SLP:000000844

Protein family/group databases

CAZyiGT31 Glycosyltransferase Family 31

PTM databases

iPTMnetiQ9Y2C3
PhosphoSitePlusiQ9Y2C3

Polymorphism and mutation databases

BioMutaiB3GALT5
DMDMi13123995

Proteomic databases

PaxDbiQ9Y2C3
PeptideAtlasiQ9Y2C3
PRIDEiQ9Y2C3
ProteomicsDBi85724

Protocols and materials databases

DNASUi10317
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000343118; ENSP00000343318; ENSG00000183778
ENST00000380618; ENSP00000369992; ENSG00000183778
ENST00000380620; ENSP00000369994; ENSG00000183778
ENST00000615480; ENSP00000480285; ENSG00000183778
GeneIDi10317
KEGGihsa:10317
UCSCiuc002yyb.3 human

Organism-specific databases

CTDi10317
DisGeNETi10317
EuPathDBiHostDB:ENSG00000183778.17
GeneCardsiB3GALT5
HGNCiHGNC:920 B3GALT5
HPAiHPA054092
HPA054684
MIMi604066 gene
neXtProtiNX_Q9Y2C3
OpenTargetsiENSG00000183778
PharmGKBiPA25213
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG2287 Eukaryota
ENOG410ZZ1B LUCA
GeneTreeiENSGT00760000118879
HOVERGENiHBG094868
InParanoidiQ9Y2C3
KOiK03877
PhylomeDBiQ9Y2C3
TreeFamiTF318639

Enzyme and pathway databases

UniPathwayi
UPA00378

BioCyciMetaCyc:MONOMER-20081

Miscellaneous databases

ChiTaRSiB3GALT5 human
GeneWikiiB3GALT5
GenomeRNAii10317
PROiPR:Q9Y2C3
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000183778 Expressed in 112 organ(s), highest expression level in palpebral conjunctiva
CleanExiHS_B3GALT5
ExpressionAtlasiQ9Y2C3 baseline and differential
GenevisibleiQ9Y2C3 HS

Family and domain databases

InterProiView protein in InterPro
IPR002659 Glyco_trans_31
PANTHERiPTHR11214 PTHR11214, 1 hit
PfamiView protein in Pfam
PF01762 Galactosyl_T, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiB3GT5_HUMAN
AccessioniPrimary (citable) accession number: Q9Y2C3
Secondary accession number(s): A8KA86
, D3DSI3, Q2M3L5, Q53Z19, Q9NY96, Q9P1X6, Q9P1X7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 21, 2001
Last sequence update: November 1, 1999
Last modified: September 12, 2018
This is version 141 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health

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