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Protein

cAMP-dependent protein kinase inhibitor gamma

Gene

PKIG

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Extremely potent competitive inhibitor of cAMP-dependent protein kinase activity, this protein interacts with the catalytic subunit of the enzyme after the cAMP-induced dissociation of its regulatory chains.By similarity

GO - Molecular functioni

  • cAMP-dependent protein kinase inhibitor activity Source: GO_Central

GO - Biological processi

Keywordsi

Molecular functionProtein kinase inhibitor

Names & Taxonomyi

Protein namesi
Recommended name:
cAMP-dependent protein kinase inhibitor gamma
Short name:
PKI-gamma
Gene namesi
Name:PKIG
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 20

Organism-specific databases

EuPathDBiHostDB:ENSG00000168734.13
HGNCiHGNC:9019 PKIG
MIMi604932 gene
neXtProtiNX_Q9Y2B9

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000168734
PharmGKBiPA33351

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001545421 – 76cAMP-dependent protein kinase inhibitor gammaAdd BLAST76

Proteomic databases

EPDiQ9Y2B9
MaxQBiQ9Y2B9
PaxDbiQ9Y2B9
PeptideAtlasiQ9Y2B9
PRIDEiQ9Y2B9
ProteomicsDBi85722

PTM databases

iPTMnetiQ9Y2B9
PhosphoSitePlusiQ9Y2B9

Expressioni

Tissue specificityi

Ubiquitous.

Gene expression databases

BgeeiENSG00000168734 Expressed in 227 organ(s), highest expression level in lower esophagus
CleanExiHS_PKIG
ExpressionAtlasiQ9Y2B9 baseline and differential
GenevisibleiQ9Y2B9 HS

Organism-specific databases

HPAiHPA042703
HPA063690

Interactioni

Protein-protein interaction databases

BioGridi116314, 9 interactors
IntActiQ9Y2B9, 2 interactors
STRINGi9606.ENSP00000338067

Structurei

3D structure databases

ProteinModelPortaliQ9Y2B9
SMRiQ9Y2B9
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the PKI family.Curated

Phylogenomic databases

eggNOGiENOG410J1ME Eukaryota
ENOG410ZDGT LUCA
GeneTreeiENSGT00390000002707
HOGENOMiHOG000059641
HOVERGENiHBG104492
InParanoidiQ9Y2B9
OMAiTDFISCD
OrthoDBiEOG091G13WE
PhylomeDBiQ9Y2B9
TreeFamiTF330809

Family and domain databases

InterProiView protein in InterPro
IPR004171 cAMP_dep_PKI
PANTHERiPTHR15416 PTHR15416, 1 hit
PfamiView protein in Pfam
PF02827 PKI, 1 hit
PIRSFiPIRSF001667 PKI, 1 hit
ProDomiView protein in ProDom or Entries sharing at least one domain
PD010366 cAMP_dep_PKI, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

Q9Y2B9-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MMEVESSYSD FISCDRTGRR NAVPDIQGDS EAVSVRKLAG DMGELALEGA
60 70
EGQVEGSAPD KEAGNQPQSS DGTTSS
Length:76
Mass (Da):7,910
Last modified:November 1, 1999 - v1
Checksum:iF01B4C73ED2CC6EE
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q5H937Q5H937_HUMAN
cAMP-dependent protein kinase inhib...
PKIG
64Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB019517 mRNA Translation: BAA77336.1
AF182032 mRNA Translation: AAD55445.1
Z97053 Genomic DNA No translation available.
CCDSiCCDS13334.1
RefSeqiNP_001268373.1, NM_001281444.1
NP_001268374.1, NM_001281445.1
NP_008997.1, NM_007066.4
NP_861520.1, NM_181804.2
NP_861521.1, NM_181805.2
XP_016883103.1, XM_017027614.1
XP_016883104.1, XM_017027615.1
XP_016883105.1, XM_017027616.1
UniGeneiHs.472831

Genome annotation databases

EnsembliENST00000349959; ENSP00000338067; ENSG00000168734
ENST00000372886; ENSP00000361977; ENSG00000168734
ENST00000372889; ENSP00000361980; ENSG00000168734
ENST00000372891; ENSP00000361981; ENSG00000168734
ENST00000372892; ENSP00000361983; ENSG00000168734
ENST00000372894; ENSP00000361985; ENSG00000168734
GeneIDi11142
KEGGihsa:11142
UCSCiuc002xmg.5 human

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB019517 mRNA Translation: BAA77336.1
AF182032 mRNA Translation: AAD55445.1
Z97053 Genomic DNA No translation available.
CCDSiCCDS13334.1
RefSeqiNP_001268373.1, NM_001281444.1
NP_001268374.1, NM_001281445.1
NP_008997.1, NM_007066.4
NP_861520.1, NM_181804.2
NP_861521.1, NM_181805.2
XP_016883103.1, XM_017027614.1
XP_016883104.1, XM_017027615.1
XP_016883105.1, XM_017027616.1
UniGeneiHs.472831

3D structure databases

ProteinModelPortaliQ9Y2B9
SMRiQ9Y2B9
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi116314, 9 interactors
IntActiQ9Y2B9, 2 interactors
STRINGi9606.ENSP00000338067

PTM databases

iPTMnetiQ9Y2B9
PhosphoSitePlusiQ9Y2B9

Proteomic databases

EPDiQ9Y2B9
MaxQBiQ9Y2B9
PaxDbiQ9Y2B9
PeptideAtlasiQ9Y2B9
PRIDEiQ9Y2B9
ProteomicsDBi85722

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000349959; ENSP00000338067; ENSG00000168734
ENST00000372886; ENSP00000361977; ENSG00000168734
ENST00000372889; ENSP00000361980; ENSG00000168734
ENST00000372891; ENSP00000361981; ENSG00000168734
ENST00000372892; ENSP00000361983; ENSG00000168734
ENST00000372894; ENSP00000361985; ENSG00000168734
GeneIDi11142
KEGGihsa:11142
UCSCiuc002xmg.5 human

Organism-specific databases

CTDi11142
EuPathDBiHostDB:ENSG00000168734.13
GeneCardsiPKIG
HGNCiHGNC:9019 PKIG
HPAiHPA042703
HPA063690
MIMi604932 gene
neXtProtiNX_Q9Y2B9
OpenTargetsiENSG00000168734
PharmGKBiPA33351
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410J1ME Eukaryota
ENOG410ZDGT LUCA
GeneTreeiENSGT00390000002707
HOGENOMiHOG000059641
HOVERGENiHBG104492
InParanoidiQ9Y2B9
OMAiTDFISCD
OrthoDBiEOG091G13WE
PhylomeDBiQ9Y2B9
TreeFamiTF330809

Miscellaneous databases

ChiTaRSiPKIG human
GeneWikiiPKIG
GenomeRNAii11142
PROiPR:Q9Y2B9
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000168734 Expressed in 227 organ(s), highest expression level in lower esophagus
CleanExiHS_PKIG
ExpressionAtlasiQ9Y2B9 baseline and differential
GenevisibleiQ9Y2B9 HS

Family and domain databases

InterProiView protein in InterPro
IPR004171 cAMP_dep_PKI
PANTHERiPTHR15416 PTHR15416, 1 hit
PfamiView protein in Pfam
PF02827 PKI, 1 hit
PIRSFiPIRSF001667 PKI, 1 hit
ProDomiView protein in ProDom or Entries sharing at least one domain
PD010366 cAMP_dep_PKI, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiIPKG_HUMAN
AccessioniPrimary (citable) accession number: Q9Y2B9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: November 1, 1999
Last modified: September 12, 2018
This is version 135 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. Human chromosome 20
    Human chromosome 20: entries, gene names and cross-references to MIM
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