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Protein

Protein canopy homolog 2

Gene

CNPY2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Positive regulator of neurite outgrowth by stabilizing myosin regulatory light chain (MRLC). It prevents MIR-mediated MRLC ubiquitination and its subsequent proteasomal degradation.

GO - Biological processi

  • enzyme linked receptor protein signaling pathway Source: GO_Central
  • negative regulation of gene expression Source: BHF-UCL
  • positive regulation of low-density lipoprotein particle receptor biosynthetic process Source: BHF-UCL
  • regulation of low-density lipoprotein particle clearance Source: BHF-UCL
  • tissue development Source: GO_Central

Names & Taxonomyi

Protein namesi
Recommended name:
Protein canopy homolog 2
Alternative name(s):
MIR-interacting saposin-like protein
Putative secreted protein Zsig9
Transmembrane protein 4
Gene namesi
Name:CNPY2
Synonyms:MSAP, TMEM4, ZSIG9
ORF Names:UNQ1943/PRO4426
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 12

Organism-specific databases

EuPathDBiHostDB:ENSG00000257727.5
HGNCiHGNC:13529 CNPY2
MIMi605861 gene
neXtProtiNX_Q9Y2B0

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Endoplasmic reticulum

Pathology & Biotechi

Organism-specific databases

DisGeNETi10330
OpenTargetsiENSG00000257727
PharmGKBiPA162382584

Polymorphism and mutation databases

BioMutaiCNPY2
DMDMi50401205

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 20Sequence analysisAdd BLAST20
ChainiPRO_000003166621 – 182Protein canopy homolog 2Add BLAST162

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi28 ↔ 171PROSITE-ProRule annotation
Disulfide bondi31 ↔ 164PROSITE-ProRule annotation
Disulfide bondi86 ↔ 137PROSITE-ProRule annotation
Modified residuei115PhosphoserineBy similarity1

Keywords - PTMi

Disulfide bond, Phosphoprotein

Proteomic databases

EPDiQ9Y2B0
PaxDbiQ9Y2B0
PeptideAtlasiQ9Y2B0
PRIDEiQ9Y2B0
ProteomicsDBi85715
85716 [Q9Y2B0-2]
TopDownProteomicsiQ9Y2B0-1 [Q9Y2B0-1]
Q9Y2B0-2 [Q9Y2B0-2]

PTM databases

iPTMnetiQ9Y2B0
PhosphoSitePlusiQ9Y2B0

Expressioni

Tissue specificityi

Expressed in different tissues. Highest levels are detected in adult placenta, liver and pancreas.1 Publication

Gene expression databases

BgeeiENSG00000257727
CleanExiHS_CNPY2
ExpressionAtlasiQ9Y2B0 baseline and differential
GenevisibleiQ9Y2B0 HS

Organism-specific databases

HPAiHPA038465
HPA038466

Interactioni

Subunit structurei

Interacts with MYLIP/MIR.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
MYLIPQ8WY643EBI-1054195,EBI-6952711

Protein-protein interaction databases

BioGridi115613, 17 interactors
DIPiDIP-50705N
IntActiQ9Y2B0, 7 interactors
MINTiQ9Y2B0
STRINGi9606.ENSP00000273308

Structurei

3D structure databases

ProteinModelPortaliQ9Y2B0
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini24 – 175Saposin B-typePROSITE-ProRule annotationAdd BLAST152

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi179 – 182Prevents secretion from ERPROSITE-ProRule annotation4

Sequence similaritiesi

Belongs to the canopy family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiKOG3782 Eukaryota
ENOG4111XSQ LUCA
GeneTreeiENSGT00390000009749
HOGENOMiHOG000233996
HOVERGENiHBG052514
InParanoidiQ9Y2B0
OrthoDBiEOG091G0HOQ
PhylomeDBiQ9Y2B0
TreeFamiTF318578

Family and domain databases

InterProiView protein in InterPro
IPR021852 DUF3456
IPR008139 SaposinB_dom
PfamiView protein in Pfam
PF11938 DUF3456, 1 hit
PROSITEiView protein in PROSITE
PS00014 ER_TARGET, 1 hit
PS50015 SAP_B, 1 hit

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9Y2B0-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MKGWGWLALL LGALLGTAWA RRSQDLHCGA CRALVDELEW EIAQVDPKKT
60 70 80 90 100
IQMGSFRINP DGSQSVVEVP YARSEAHLTE LLEEICDRMK EYGEQIDPST
110 120 130 140 150
HRKNYVRVVG RNGESSELDL QGIRIDSDIS GTLKFACESI VEEYEDELIE
160 170 180
FFSREADNVK DKLCSKRTDL CDHALHISHD EL
Length:182
Mass (Da):20,652
Last modified:November 1, 1999 - v1
Checksum:iBE726D302490733F
GO
Isoform 2 (identifier: Q9Y2B0-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     70-84: PYARSEAHLTELLEE → TVTVPPNKVAHSGFG
     85-182: Missing.

Show »
Length:84
Mass (Da):9,117
Checksum:iDCA2B08EC77EF1F0
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_01088470 – 84PYARS…ELLEE → TVTVPPNKVAHSGFG in isoform 2. 2 PublicationsAdd BLAST15
Alternative sequenceiVSP_01088585 – 182Missing in isoform 2. 2 PublicationsAdd BLAST98

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB015631 mRNA Translation: BAA76498.1
AY032624 mRNA Translation: AAK38148.1
AF186113 mRNA Translation: AAF01431.1
AY359102 mRNA Translation: AAQ89460.1
AK312921 mRNA Translation: BAG35766.1
CH471054 Genomic DNA Translation: EAW96926.1
BC001027 mRNA Translation: AAH01027.1
BC065015 mRNA Translation: AAH65015.1
CCDSiCCDS8914.1 [Q9Y2B0-1]
RefSeqiNP_001177920.1, NM_001190991.2 [Q9Y2B0-2]
NP_055070.1, NM_014255.6 [Q9Y2B0-1]
UniGeneiHs.8752

Genome annotation databases

EnsembliENST00000273308; ENSP00000273308; ENSG00000257727 [Q9Y2B0-1]
GeneIDi10330
KEGGihsa:10330
UCSCiuc001sku.3 human [Q9Y2B0-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiCNPY2_HUMAN
AccessioniPrimary (citable) accession number: Q9Y2B0
Secondary accession number(s): B2R7B9, Q9UHE9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 19, 2004
Last sequence update: November 1, 1999
Last modified: June 20, 2018
This is version 140 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

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