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Entry version 172 (16 Oct 2019)
Sequence version 1 (01 Nov 1999)
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Protein

Nck-associated protein 1

Gene

NCKAP1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Part of the WAVE complex that regulates lamellipodia formation. The WAVE complex regulates actin filament reorganization via its interaction with the Arp2/3 complex. Actin remodeling activity is regulated by RAC1. As component of the WAVE1 complex, required for BDNF-NTRK2 endocytic trafficking and signaling from early endosomes.By similarity

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processHost-virus interaction

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-2029482 Regulation of actin dynamics for phagocytic cup formation
R-HSA-4420097 VEGFA-VEGFR2 Pathway
R-HSA-5663213 RHO GTPases Activate WASPs and WAVEs

SIGNOR Signaling Network Open Resource

More...
SIGNORi
Q9Y2A7

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Nck-associated protein 1
Short name:
NAP 1
Alternative name(s):
Membrane-associated protein HEM-2
p125Nap1
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:NCKAP1
Synonyms:HEM2, KIAA0587, NAP1
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 2

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:7666 NCKAP1

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
604891 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q9Y2A7

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei995 – 1015HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Cell membrane, Cell projection, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
10787

Open Targets

More...
OpenTargetsi
ENSG00000061676

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA31468

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q9Y2A7

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
NCKAP1

Domain mapping of disease mutations (DMDM)

More...
DMDMi
12643947

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section indicates that the initiator methionine is cleaved from the mature protein.<p><a href='/help/init_met' target='_top'>More...</a></p>Initiator methionineiRemovedCombined sources
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002161722 – 1128Nck-associated protein 1Add BLAST1127

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei2N-acetylserineCombined sources1

Keywords - PTMi

Acetylation

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q9Y2A7

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q9Y2A7

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
Q9Y2A7

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q9Y2A7

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q9Y2A7

PeptideAtlas

More...
PeptideAtlasi
Q9Y2A7

PRoteomics IDEntifications database

More...
PRIDEi
Q9Y2A7

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
85712 [Q9Y2A7-1]
85713 [Q9Y2A7-2]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q9Y2A7

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q9Y2A7

SwissPalm database of S-palmitoylation events

More...
SwissPalmi
Q9Y2A7

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed in all tissues examined except peripheral blood leukocytes, with highest expression in brain, heart, and skeletal muscle.

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000061676 Expressed in 244 organ(s), highest expression level in cerebral cortex

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
Q9Y2A7 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA020449

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Component of the WAVE1 complex composed of ABI2, CYFIP1 or CYFIP2, BRK1, NCKAP1 and WASF1/WAVE1. Within the complex, a heterodimer containing NCKAP1 and CYFIP1 interacts with a heterotrimer formed by WAVE1, ABI2 and BRK1.

Component of the WAVE2 complex composed of ABI1, CYFIP1/SRA1, NCKAP1/NAP1 and WASF2/WAVE2. CYFIP2 binds to activated RAC1 which causes the complex to dissociate, releasing activated WASF1. The complex can also be activated by NCK1. Associates preferentially with the first SH3 domain of NCK.

Interacts with NYAP1, NYAP2 and MYO16 (By similarity).

By similarity

(Microbial infection) Interacts with human cytomegalovirus protein UL135.

1 Publication

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
116003, 66 interactors

CORUM comprehensive resource of mammalian protein complexes

More...
CORUMi
Q9Y2A7

Database of interacting proteins

More...
DIPi
DIP-31119N

Protein interaction database and analysis system

More...
IntActi
Q9Y2A7, 50 interactors

Molecular INTeraction database

More...
MINTi
Q9Y2A7

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000354251

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

11128
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
Q9Y2A7

Database of comparative protein structure models

More...
ModBasei
Search...

Protein Data Bank in Europe - Knowledge Base

More...
PDBe-KBi
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...
EvolutionaryTracei
Q9Y2A7

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the HEM-1/HEM-2 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1917 Eukaryota
ENOG410XPQI LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00390000016619

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

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HOGENOMi
HOG000231880

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
Q9Y2A7

KEGG Orthology (KO)

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KOi
K05750

Identification of Orthologs from Complete Genome Data

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OMAi
VGMVMYN

Database of Orthologous Groups

More...
OrthoDBi
138196at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q9Y2A7

TreeFam database of animal gene trees

More...
TreeFami
TF313683

Family and domain databases

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR019137 Nck-associated_protein-1

The PANTHER Classification System

More...
PANTHERi
PTHR12093 PTHR12093, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF09735 Nckap1, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
Isoform 1 (identifier: Q9Y2A7-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MSRSVLQPSQ QKLAEKLTIL NDRGVGMLTR LYNIKKACGD PKAKPSYLID
60 70 80 90 100
KNLESAVKFI VRKFPAVETR NNNQQLAQLQ KEKSEILKNL ALYYFTFVDV
110 120 130 140 150
MEFKDHVCEL LNTIDVCQVF FDITVNFDLT KNYLDLIITY TTLMILLSRI
160 170 180 190 200
EERKAIIGLY NYAHEMTHGA SDREYPRLGQ MIVDYENPLK KMMEEFVPHS
210 220 230 240 250
KSLSDALISL QMVYPRRNLS ADQWRNAQLL SLISAPSTML NPAQSDTMPC
260 270 280 290 300
EYLSLDAMEK WIIFGFILCH GILNTDATAL NLWKLALQSS SCLSLFRDEV
310 320 330 340 350
FHIHKAAEDL FVNIRGYNKR INDIRECKEA AVSHAGSMHR ERRKFLRSAL
360 370 380 390 400
KELATVLSDQ PGLLGPKALF VFMALSFARD EIIWLLRHAD NMPKKSADDF
410 420 430 440 450
IDKHIAELIF YMEELRAHVR KYGPVMQRYY VQYLSGFDAV VLNELVQNLS
460 470 480 490 500
VCPEDESIIM SSFVNTMTSL SVKQVEDGEV FDFRGMRLDW FRLQAYTSVS
510 520 530 540 550
KASLGLADHR ELGKMMNTII FHTKMVDSLV EMLVETSDLS IFCFYSRAFE
560 570 580 590 600
KMFQQCLELP SQSRYSIAFP LLCTHFMSCT HELCPEERHH IGDRSLSLCN
610 620 630 640 650
MFLDEMAKQA RNLITDICTE QCTLSDQLLP KHCAKTISQA VNKKSKKQTG
660 670 680 690 700
KKGEPEREKP GVESMRKNRL VVTNLDKLHT ALSELCFSIN YVPNMVVWEH
710 720 730 740 750
TFTPREYLTS HLEIRFTKSI VGMTMYNQAT QEIAKPSELL TSVRAYMTVL
760 770 780 790 800
QSIENYVQID ITRVFNNVLL QQTQHLDSHG EPTITSLYTN WYLETLLRQV
810 820 830 840 850
SNGHIAYFPA MKAFVNLPTE NELTFNAEEY SDISEMRSLS ELLGPYGMKF
860 870 880 890 900
LSESLMWHIS SQVAELKKLV VENVDVLTQM RTSFDKPDQM AALFKRLSSV
910 920 930 940 950
DSVLKRMTII GVILSFRSLA QEALRDVLSY HIPFLVSSIE DFKDHIPRET
960 970 980 990 1000
DMKVAMNVYE LSSAAGLPCE IDPALVVALS SQKSENISPE EEYKIACLLM
1010 1020 1030 1040 1050
VFVAVSLPTL ASNVMSQYSP AIEGHCNNIH CLAKAINQIA AALFTIHKGS
1060 1070 1080 1090 1100
IEDRLKEFLA LASSSLLKIG QETDKTTTRN RESVYLLLDM IVQESPFLTM
1110 1120
DLLESCFPYV LLRNAYHAVY KQSVTSSA
Length:1,128
Mass (Da):128,790
Last modified:November 1, 1999 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i12D32BAC7080CB5A
GO
Isoform 2 (identifier: Q9Y2A7-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     36-36: K → KQGQVWK

Show »
Length:1,134
Mass (Da):129,517
Checksum:i71019B9B0BCA760D
GO

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence BAA25513 differs from that shown. Reason: Erroneous initiation. Extended N-terminus.Curated

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_03655836K → KQGQVWK in isoform 2. 1 Publication1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AB014509 mRNA Translation: BAA77295.1
AB011159 mRNA Translation: BAA25513.2 Different initiation.
AK292914 mRNA Translation: BAF85603.1
BT007033 mRNA Translation: AAP35681.1
AC108514 Genomic DNA Translation: AAX93118.1
AC064871 Genomic DNA Translation: AAY24196.1
BC015025 mRNA Translation: AAH15025.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS2287.1 [Q9Y2A7-1]
CCDS2288.1 [Q9Y2A7-2]

NCBI Reference Sequences

More...
RefSeqi
NP_038464.1, NM_013436.4 [Q9Y2A7-1]
NP_995314.1, NM_205842.2 [Q9Y2A7-2]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000360982; ENSP00000354251; ENSG00000061676 [Q9Y2A7-2]
ENST00000361354; ENSP00000355348; ENSG00000061676 [Q9Y2A7-1]

Database of genes from NCBI RefSeq genomes

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GeneIDi
10787

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:10787

UCSC genome browser

More...
UCSCi
uc002upb.5 human [Q9Y2A7-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB014509 mRNA Translation: BAA77295.1
AB011159 mRNA Translation: BAA25513.2 Different initiation.
AK292914 mRNA Translation: BAF85603.1
BT007033 mRNA Translation: AAP35681.1
AC108514 Genomic DNA Translation: AAX93118.1
AC064871 Genomic DNA Translation: AAY24196.1
BC015025 mRNA Translation: AAH15025.1
CCDSiCCDS2287.1 [Q9Y2A7-1]
CCDS2288.1 [Q9Y2A7-2]
RefSeqiNP_038464.1, NM_013436.4 [Q9Y2A7-1]
NP_995314.1, NM_205842.2 [Q9Y2A7-2]

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...
PDBei

Protein Data Bank RCSB

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RCSB PDBi

Protein Data Bank Japan

More...
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3P8CX-ray2.29B1-1128[»]
4N78X-ray2.43B1-1128[»]
SMRiQ9Y2A7
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGridi116003, 66 interactors
CORUMiQ9Y2A7
DIPiDIP-31119N
IntActiQ9Y2A7, 50 interactors
MINTiQ9Y2A7
STRINGi9606.ENSP00000354251

PTM databases

iPTMnetiQ9Y2A7
PhosphoSitePlusiQ9Y2A7
SwissPalmiQ9Y2A7

Polymorphism and mutation databases

BioMutaiNCKAP1
DMDMi12643947

Proteomic databases

EPDiQ9Y2A7
jPOSTiQ9Y2A7
MassIVEiQ9Y2A7
MaxQBiQ9Y2A7
PaxDbiQ9Y2A7
PeptideAtlasiQ9Y2A7
PRIDEiQ9Y2A7
ProteomicsDBi85712 [Q9Y2A7-1]
85713 [Q9Y2A7-2]

Protocols and materials databases

The DNASU plasmid repository

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DNASUi
10787

Genome annotation databases

EnsembliENST00000360982; ENSP00000354251; ENSG00000061676 [Q9Y2A7-2]
ENST00000361354; ENSP00000355348; ENSG00000061676 [Q9Y2A7-1]
GeneIDi10787
KEGGihsa:10787
UCSCiuc002upb.5 human [Q9Y2A7-1]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
10787
DisGeNETi10787

GeneCards: human genes, protein and diseases

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GeneCardsi
NCKAP1
HGNCiHGNC:7666 NCKAP1
HPAiHPA020449
MIMi604891 gene
neXtProtiNX_Q9Y2A7
OpenTargetsiENSG00000061676
PharmGKBiPA31468

Human Unidentified Gene-Encoded large proteins database

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HUGEi
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GenAtlas: human gene database

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GenAtlasi
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Phylogenomic databases

eggNOGiKOG1917 Eukaryota
ENOG410XPQI LUCA
GeneTreeiENSGT00390000016619
HOGENOMiHOG000231880
InParanoidiQ9Y2A7
KOiK05750
OMAiVGMVMYN
OrthoDBi138196at2759
PhylomeDBiQ9Y2A7
TreeFamiTF313683

Enzyme and pathway databases

ReactomeiR-HSA-2029482 Regulation of actin dynamics for phagocytic cup formation
R-HSA-4420097 VEGFA-VEGFR2 Pathway
R-HSA-5663213 RHO GTPases Activate WASPs and WAVEs
SIGNORiQ9Y2A7

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
NCKAP1 human
EvolutionaryTraceiQ9Y2A7

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
NCKAP1

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
10787
PharosiQ9Y2A7

Protein Ontology

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PROi
PR:Q9Y2A7

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
Search...

Gene expression databases

BgeeiENSG00000061676 Expressed in 244 organ(s), highest expression level in cerebral cortex
GenevisibleiQ9Y2A7 HS

Family and domain databases

InterProiView protein in InterPro
IPR019137 Nck-associated_protein-1
PANTHERiPTHR12093 PTHR12093, 1 hit
PfamiView protein in Pfam
PF09735 Nckap1, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiNCKP1_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9Y2A7
Secondary accession number(s): O60329
, Q53QN5, Q53S94, Q53Y35
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 11, 2001
Last sequence update: November 1, 1999
Last modified: October 16, 2019
This is version 172 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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