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Protein

Zinc finger protein 443

Gene

ZNF443

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

May be involved in transcriptional regulation.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri134 – 159C2H2-type 1; degeneratePROSITE-ProRule annotationAdd BLAST26
Zinc fingeri169 – 191C2H2-type 2; degeneratePROSITE-ProRule annotationAdd BLAST23
Zinc fingeri197 – 219C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri225 – 247C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri253 – 275C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri281 – 303C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri309 – 331C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri337 – 359C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri365 – 387C2H2-type 9PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri393 – 415C2H2-type 10PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri421 – 443C2H2-type 11PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri449 – 471C2H2-type 12PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri477 – 498C2H2-type 13; degeneratePROSITE-ProRule annotationAdd BLAST22
Zinc fingeri504 – 526C2H2-type 14PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri532 – 554C2H2-type 15PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri560 – 582C2H2-type 16PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri588 – 610C2H2-type 17PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri616 – 638C2H2-type 18PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri649 – 671C2H2-type 19PROSITE-ProRule annotationAdd BLAST23

GO - Molecular functioni

GO - Biological processi

  • apoptotic process Source: ProtInc
  • transcription, DNA-templated Source: UniProtKB-KW

Keywordsi

Molecular functionDNA-binding
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

Enzyme and pathway databases

ReactomeiR-HSA-212436 Generic Transcription Pathway

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein 443
Alternative name(s):
Krueppel-type zinc finger protein ZK1
Gene namesi
Name:ZNF443
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

EuPathDBiHostDB:ENSG00000180855.15
HGNCiHGNC:20878 ZNF443
MIMi606697 gene
neXtProtiNX_Q9Y2A4

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi10224
OpenTargetsiENSG00000180855
PharmGKBiPA134968382

Polymorphism and mutation databases

BioMutaiZNF443
DMDMi296453041

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000475921 – 671Zinc finger protein 443Add BLAST671

Proteomic databases

EPDiQ9Y2A4
MaxQBiQ9Y2A4
PaxDbiQ9Y2A4
PeptideAtlasiQ9Y2A4
PRIDEiQ9Y2A4
ProteomicsDBi85711

PTM databases

iPTMnetiQ9Y2A4
PhosphoSitePlusiQ9Y2A4

Expressioni

Inductioni

Induced following exposure to ionizing radiation.

Gene expression databases

BgeeiENSG00000180855
CleanExiHS_ZNF443
ExpressionAtlasiQ9Y2A4 baseline and differential
GenevisibleiQ9Y2A4 HS

Organism-specific databases

HPAiHPA003150
HPA018683

Interactioni

Protein-protein interaction databases

BioGridi115518, 1 interactor
IntActiQ9Y2A4, 1 interactor
STRINGi9606.ENSP00000301547

Structurei

3D structure databases

ProteinModelPortaliQ9Y2A4
SMRiQ9Y2A4
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini4 – 86KRABPROSITE-ProRule annotationAdd BLAST83

Sequence similaritiesi

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri134 – 159C2H2-type 1; degeneratePROSITE-ProRule annotationAdd BLAST26
Zinc fingeri169 – 191C2H2-type 2; degeneratePROSITE-ProRule annotationAdd BLAST23
Zinc fingeri197 – 219C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri225 – 247C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri253 – 275C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri281 – 303C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri309 – 331C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri337 – 359C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri365 – 387C2H2-type 9PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri393 – 415C2H2-type 10PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri421 – 443C2H2-type 11PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri449 – 471C2H2-type 12PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri477 – 498C2H2-type 13; degeneratePROSITE-ProRule annotationAdd BLAST22
Zinc fingeri504 – 526C2H2-type 14PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri532 – 554C2H2-type 15PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri560 – 582C2H2-type 16PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri588 – 610C2H2-type 17PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri616 – 638C2H2-type 18PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri649 – 671C2H2-type 19PROSITE-ProRule annotationAdd BLAST23

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721 Eukaryota
COG5048 LUCA
GeneTreeiENSGT00760000119089
HOVERGENiHBG018163
InParanoidiQ9Y2A4
KOiK09228
OMAiDSSSCLI
OrthoDBiEOG091G02KC
PhylomeDBiQ9Y2A4
TreeFamiTF343410

Family and domain databases

CDDicd07765 KRAB_A-box, 1 hit
InterProiView protein in InterPro
IPR001909 KRAB
IPR036051 KRAB_dom_sf
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type
PfamiView protein in Pfam
PF01352 KRAB, 1 hit
SMARTiView protein in SMART
SM00349 KRAB, 1 hit
SM00355 ZnF_C2H2, 19 hits
SUPFAMiSSF109640 SSF109640, 1 hit
SSF57667 SSF57667, 10 hits
PROSITEiView protein in PROSITE
PS50805 KRAB, 1 hit
PS00028 ZINC_FINGER_C2H2_1, 16 hits
PS50157 ZINC_FINGER_C2H2_2, 18 hits

Sequencei

Sequence statusi: Complete.

Q9Y2A4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MASVALEDVA VNFTREEWAL LGPCQKNLYK DVMQETIRNL DCVVMKWKDQ
60 70 80 90 100
NIEDQYRYPR KNLRCRMLER FVESKDGTQC GETSSQIQDS IVTKNTLPGV
110 120 130 140 150
GPCESSMRGE KVMGHSSLNC YIRVGAGHKP HEYHECGEKP DTHKQRGKAF
160 170 180 190 200
SYHNSFQTHE RLHTGKKPYD CKECGKSFSS LGNLQRHMAV QRGDGPYKCK
210 220 230 240 250
LCGKAFFWPS LLHMHERTHT GEKPYECKQC SKAFSFYSSY LRHERTHTGE
260 270 280 290 300
KPYECKQCSK AFPFYSSYLR HERTHTGEKP YKCKQCSKAF PDSSSCLIHE
310 320 330 340 350
RTHTGEKPYT CKQCGKAFSV SGSLQRHETT HSAEKPYACQ QCGKAFHHLG
360 370 380 390 400
SFQRHMIRHT GNGPHKCKIC GKGFDCPSSL QSHERTHTGE KPYECKQCGK
410 420 430 440 450
ALSHRSSFRS HMIMHTGDGP HKCKVCGKAF VYPSVFQRHE RTHTAEKPYK
460 470 480 490 500
CKQCGKAYRI SSSLRRHETT HTGEKPYKCK LGKACIDFCS FQNHKTTHTG
510 520 530 540 550
EKPYECKECG KAFSRFRYLS RHKRTHTGEK PYECKTCRKA FGHYDNLKVH
560 570 580 590 600
ERIHSGEKPY ECKECGKAFS WLTCFLRHER IHMREKSYEC PQCGKAFTHS
610 620 630 640 650
RFLQGHEKTH TGENPYECKE CGKAFASLSS LHRHKKTHWK KTHTGENPYE
660 670
CKECGKAFAS LSSLHRHKKT H
Length:671
Mass (Da):77,516
Last modified:May 18, 2010 - v2
Checksum:iA715F816ADFD9A19
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti72V → I in BAA75543 (PubMed:9731181).Curated1
Sequence conflicti72V → I in AAH32753 (PubMed:15489334).Curated1
Sequence conflicti480K → T in BAA75543 (PubMed:9731181).Curated1
Sequence conflicti480K → T in AAH32753 (PubMed:15489334).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_061947111K → I. Corresponds to variant dbSNP:rs28599549Ensembl.1
Natural variantiVAR_059917111K → N. Corresponds to variant dbSNP:rs4239550Ensembl.1
Natural variantiVAR_061948397Q → H. Corresponds to variant dbSNP:rs35699767Ensembl.1
Natural variantiVAR_059918485C → F2 PublicationsCorresponds to variant dbSNP:rs10422063Ensembl.1
Natural variantiVAR_057420591P → Q. Corresponds to variant dbSNP:rs7256321Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB011414 mRNA Translation: BAA75543.1
AC008758 Genomic DNA No translation available.
BC032753 mRNA Translation: AAH32753.1
CCDSiCCDS32918.1
PIRiJE0288
RefSeqiNP_005806.2, NM_005815.4
UniGeneiHs.636894
Hs.720755

Genome annotation databases

EnsembliENST00000301547; ENSP00000301547; ENSG00000180855
GeneIDi10224
KEGGihsa:10224
UCSCiuc002mtu.4 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiZN443_HUMAN
AccessioniPrimary (citable) accession number: Q9Y2A4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 9, 2003
Last sequence update: May 18, 2010
Last modified: June 20, 2018
This is version 146 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

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