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Protein

Trafficking protein particle complex subunit 4

Gene

TRAPPC4

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May play a role in vesicular transport from endoplasmic reticulum to Golgi.

GO - Molecular functioni

  • Rab guanyl-nucleotide exchange factor activity Source: GO_Central

GO - Biological processi

  • COPII vesicle coating Source: Reactome
  • dendrite development Source: UniProtKB
  • ER to Golgi vesicle-mediated transport Source: GO_Central

Keywordsi

Biological processER-Golgi transport, Transport

Enzyme and pathway databases

ReactomeiR-HSA-204005 COPII-mediated vesicle transport
R-HSA-3000170 Syndecan interactions
R-HSA-8876198 RAB GEFs exchange GTP for GDP on RABs

Names & Taxonomyi

Protein namesi
Recommended name:
Trafficking protein particle complex subunit 4
Alternative name(s):
Hematopoietic stem/progenitor cell protein 172
Synbindin
TRS23 homolog
Gene namesi
Name:TRAPPC4
Synonyms:SBDN
ORF Names:CGI-104, HSPC172, PTD009
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 11

Organism-specific databases

EuPathDBiHostDB:ENSG00000196655.9
HGNCiHGNC:19943 TRAPPC4
MIMi610971 gene
neXtProtiNX_Q9Y296

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Endoplasmic reticulum, Golgi apparatus

Pathology & Biotechi

Organism-specific databases

DisGeNETi51399
OpenTargetsiENSG00000196655
PharmGKBiPA134906910

Chemistry databases

DrugBankiDB08342 S-PALMITOYL-L-CYSTEINE

Polymorphism and mutation databases

BioMutaiTRAPPC4
DMDMi20178121

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002115691 – 219Trafficking protein particle complex subunit 4Add BLAST219

Proteomic databases

EPDiQ9Y296
PaxDbiQ9Y296
PeptideAtlasiQ9Y296
PRIDEiQ9Y296
ProteomicsDBi85704

PTM databases

iPTMnetiQ9Y296
PhosphoSitePlusiQ9Y296

Expressioni

Gene expression databases

BgeeiENSG00000196655 Expressed in 226 organ(s), highest expression level in right testis
CleanExiHS_TRAPPC4
ExpressionAtlasiQ9Y296 baseline and differential
GenevisibleiQ9Y296 HS

Organism-specific databases

HPAiHPA039752
HPA041371

Interactioni

Subunit structurei

Component of the multisubunit TRAPP (transport protein particle) complex, which includes at least TRAPPC2, TRAPPC2L, TRAPPC3, TRAPPC3L, TRAPPC4, TRAPPC5, TRAPPC8, TRAPPC9, TRAPPC10, TRAPPC11 and TRAPPC12. Interacts with SDC2 (By similarity).By similarity

Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

BioGridi119523, 45 interactors
CORUMiQ9Y296
DIPiDIP-37871N
IntActiQ9Y296, 12 interactors
STRINGi9606.ENSP00000436005

Structurei

Secondary structure

1219
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

DisProtiDP00562
ProteinModelPortaliQ9Y296
SMRiQ9Y296
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ9Y296

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG3369 Eukaryota
COG5122 LUCA
GeneTreeiENSGT00510000047061
HOGENOMiHOG000165618
HOVERGENiHBG054226
InParanoidiQ9Y296
KOiK20303
OMAiGQRDGIN
PhylomeDBiQ9Y296
TreeFamiTF314561

Family and domain databases

InterProiView protein in InterPro
IPR011012 Longin-like_dom_sf
IPR007233 TRAPPC
PANTHERiPTHR23249 PTHR23249, 1 hit
PfamiView protein in Pfam
PF04099 Sybindin, 1 hit
SMARTiView protein in SMART
SM01399 Sybindin, 1 hit
SUPFAMiSSF64356 SSF64356, 1 hit

Sequences (2+)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 6 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q9Y296-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MAIFSVYVVN KAGGLIYQLD SYAPRAEAEK TFSYPLDLLL KLHDERVLVA
60 70 80 90 100
FGQRDGIRVG HAVLAINGMD VNGRYTADGK EVLEYLGNPA NYPVSIRFGR
110 120 130 140 150
PRLTSNEKLM LASMFHSLFA IGSQLSPEQG SSGIEMLETD TFKLHCYQTL
160 170 180 190 200
TGIKFVVLAD PRQAGIDSLL RKIYEIYSDF ALKNPFYSLE MPIRCELFDQ
210
NLKLALEVAE KAGTFGPGS
Length:219
Mass (Da):24,340
Last modified:November 1, 1999 - v1
Checksum:iC6ADE525B7CFB731
GO
Isoform 2 (identifier: Q9Y296-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     81-134: Missing.

Note: No experimental confirmation available.
Show »
Length:165
Mass (Da):18,446
Checksum:i9ED57477C1259464
GO

Computationally mapped potential isoform sequencesi

There are 6 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E9PKS9E9PKS9_HUMAN
Trafficking protein particle comple...
TRAPPC4
126Annotation score:
E9PQE8E9PQE8_HUMAN
Trafficking protein particle comple...
TRAPPC4
176Annotation score:
J3KP27J3KP27_HUMAN
Trafficking protein particle comple...
TRAPPC4
181Annotation score:
E9PN70E9PN70_HUMAN
Trafficking protein particle comple...
TRAPPC4
257Annotation score:
G5EA23G5EA23_HUMAN
HCG38438, isoform CRA_a
TRAPPC4 hCG_38438
126Annotation score:
G3V1A0G3V1A0_HUMAN
HCG38438, isoform CRA_b
TRAPPC4 hCG_38438
117Annotation score:

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_05239778D → A. Corresponds to variant dbSNP:rs11640Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_05634881 – 134Missing in isoform 2. 1 PublicationAdd BLAST54

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF105025 mRNA Translation: AAF21897.1
AF078862 mRNA Translation: AAD44494.1
AF161520 mRNA Translation: AAF29135.1
AF151862 mRNA Translation: AAD34099.1
AK290520 mRNA Translation: BAF83209.1
AK297422 mRNA Translation: BAG59853.1
AP003392 Genomic DNA No translation available.
CH471065 Genomic DNA Translation: EAW67430.1
BC010866 mRNA Translation: AAH10866.1
CCDSiCCDS81633.1 [Q9Y296-2]
CCDS8407.1 [Q9Y296-1]
RefSeqiNP_001305415.1, NM_001318486.1
NP_001305417.1, NM_001318488.1
NP_001305418.1, NM_001318489.1 [Q9Y296-2]
NP_001305419.1, NM_001318490.1
NP_001305421.1, NM_001318492.1
NP_001305423.1, NM_001318494.1
NP_057230.1, NM_016146.5 [Q9Y296-1]
UniGeneiHs.132760

Genome annotation databases

EnsembliENST00000434101; ENSP00000405033; ENSG00000196655 [Q9Y296-2]
ENST00000533632; ENSP00000436005; ENSG00000196655 [Q9Y296-1]
ENST00000629243; ENSP00000487467; ENSG00000280495 [Q9Y296-1]
ENST00000629713; ENSP00000486496; ENSG00000280495 [Q9Y296-2]
GeneIDi51399
KEGGihsa:51399
UCSCiuc010ryo.4 human [Q9Y296-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF105025 mRNA Translation: AAF21897.1
AF078862 mRNA Translation: AAD44494.1
AF161520 mRNA Translation: AAF29135.1
AF151862 mRNA Translation: AAD34099.1
AK290520 mRNA Translation: BAF83209.1
AK297422 mRNA Translation: BAG59853.1
AP003392 Genomic DNA No translation available.
CH471065 Genomic DNA Translation: EAW67430.1
BC010866 mRNA Translation: AAH10866.1
CCDSiCCDS81633.1 [Q9Y296-2]
CCDS8407.1 [Q9Y296-1]
RefSeqiNP_001305415.1, NM_001318486.1
NP_001305417.1, NM_001318488.1
NP_001305418.1, NM_001318489.1 [Q9Y296-2]
NP_001305419.1, NM_001318490.1
NP_001305421.1, NM_001318492.1
NP_001305423.1, NM_001318494.1
NP_057230.1, NM_016146.5 [Q9Y296-1]
UniGeneiHs.132760

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2J3TX-ray2.40D1-219[»]
2JSNNMR-A19-106[»]
2ZMVX-ray2.80A/B1-219[»]
DisProtiDP00562
ProteinModelPortaliQ9Y296
SMRiQ9Y296
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi119523, 45 interactors
CORUMiQ9Y296
DIPiDIP-37871N
IntActiQ9Y296, 12 interactors
STRINGi9606.ENSP00000436005

Chemistry databases

DrugBankiDB08342 S-PALMITOYL-L-CYSTEINE

PTM databases

iPTMnetiQ9Y296
PhosphoSitePlusiQ9Y296

Polymorphism and mutation databases

BioMutaiTRAPPC4
DMDMi20178121

Proteomic databases

EPDiQ9Y296
PaxDbiQ9Y296
PeptideAtlasiQ9Y296
PRIDEiQ9Y296
ProteomicsDBi85704

Protocols and materials databases

DNASUi51399
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000434101; ENSP00000405033; ENSG00000196655 [Q9Y296-2]
ENST00000533632; ENSP00000436005; ENSG00000196655 [Q9Y296-1]
ENST00000629243; ENSP00000487467; ENSG00000280495 [Q9Y296-1]
ENST00000629713; ENSP00000486496; ENSG00000280495 [Q9Y296-2]
GeneIDi51399
KEGGihsa:51399
UCSCiuc010ryo.4 human [Q9Y296-1]

Organism-specific databases

CTDi51399
DisGeNETi51399
EuPathDBiHostDB:ENSG00000196655.9
GeneCardsiTRAPPC4
HGNCiHGNC:19943 TRAPPC4
HPAiHPA039752
HPA041371
MIMi610971 gene
neXtProtiNX_Q9Y296
OpenTargetsiENSG00000196655
PharmGKBiPA134906910
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3369 Eukaryota
COG5122 LUCA
GeneTreeiENSGT00510000047061
HOGENOMiHOG000165618
HOVERGENiHBG054226
InParanoidiQ9Y296
KOiK20303
OMAiGQRDGIN
PhylomeDBiQ9Y296
TreeFamiTF314561

Enzyme and pathway databases

ReactomeiR-HSA-204005 COPII-mediated vesicle transport
R-HSA-3000170 Syndecan interactions
R-HSA-8876198 RAB GEFs exchange GTP for GDP on RABs

Miscellaneous databases

ChiTaRSiTRAPPC4 human
EvolutionaryTraceiQ9Y296
GeneWikiiTRAPPC4
GenomeRNAii51399
PROiPR:Q9Y296
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000196655 Expressed in 226 organ(s), highest expression level in right testis
CleanExiHS_TRAPPC4
ExpressionAtlasiQ9Y296 baseline and differential
GenevisibleiQ9Y296 HS

Family and domain databases

InterProiView protein in InterPro
IPR011012 Longin-like_dom_sf
IPR007233 TRAPPC
PANTHERiPTHR23249 PTHR23249, 1 hit
PfamiView protein in Pfam
PF04099 Sybindin, 1 hit
SMARTiView protein in SMART
SM01399 Sybindin, 1 hit
SUPFAMiSSF64356 SSF64356, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiTPPC4_HUMAN
AccessioniPrimary (citable) accession number: Q9Y296
Secondary accession number(s): A8K3A5, B4DME1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 16, 2002
Last sequence update: November 1, 1999
Last modified: November 7, 2018
This is version 160 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
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