UniProtKB - Q9Y296 (TPPC4_HUMAN)
Trafficking protein particle complex subunit 4
TRAPPC4
Functioni
GO - Biological processi
- autophagy Source: UniProtKB
- COPII vesicle coating Source: Reactome
- dendrite development Source: UniProtKB
- endoplasmic reticulum to Golgi vesicle-mediated transport Source: UniProtKB
Keywordsi
Biological process | ER-Golgi transport, Transport |
Enzyme and pathway databases
PathwayCommonsi | Q9Y296 |
Reactomei | R-HSA-204005, COPII-mediated vesicle transport R-HSA-3000170, Syndecan interactions R-HSA-8876198, RAB GEFs exchange GTP for GDP on RABs |
Names & Taxonomyi
Protein namesi | Recommended name: Trafficking protein particle complex subunit 4CuratedAlternative name(s): Hematopoietic stem/progenitor cell protein 172 SynbindinBy similarity TRS23 homolog |
Gene namesi | ORF Names:CGI-104, HSPC172, PTD009 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:19943, TRAPPC4 |
MIMi | 610971, gene |
neXtProti | NX_Q9Y296 |
VEuPathDBi | HostDB:ENSG00000196655.9 |
Subcellular locationi
Golgi apparatus
- Golgi apparatus membrane By similarity
Endoplasmic reticulum
- Endoplasmic reticulum By similarity
Plasma membrane
- postsynaptic cell membrane By similarity
Other locations
- Vesicle By similarity
Note: Associated with postsynaptic membranes and in intracellular cisterns and vesicles (Golgi).By similarity
Cytosol
- cytosol Source: Reactome
Endoplasmic reticulum
- endoplasmic reticulum Source: UniProtKB-SubCell
Golgi apparatus
- Golgi membrane Source: UniProtKB-SubCell
- Golgi stack Source: UniProtKB
Plasma Membrane
- postsynaptic membrane Source: UniProtKB-SubCell
Other locations
- dendrite Source: UniProtKB
- synapse Source: UniProtKB
- synaptic vesicle Source: UniProtKB
- TRAPP complex Source: UniProtKB
Keywords - Cellular componenti
Cell junction, Cell membrane, Endoplasmic reticulum, Golgi apparatus, Membrane, Postsynaptic cell membrane, SynapsePathology & Biotechi
Involvement in diseasei
Neurodevelopmental disorder with epilepsy, spasticity, and brain atrophy (NEDESBA)1 Publication
Organism-specific databases
DisGeNETi | 51399 |
MalaCardsi | TRAPPC4 |
MIMi | 618741, phenotype |
OpenTargetsi | ENSG00000196655 |
Orphaneti | 528084, Non-specific syndromic intellectual disability |
PharmGKBi | PA134906910 |
Miscellaneous databases
Pharosi | Q9Y296, Tbio |
Chemistry databases
DrugBanki | DB08342, S-palmitoyl-L-cysteine |
Genetic variation databases
BioMutai | TRAPPC4 |
DMDMi | 20178121 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000211569 | 1 – 219 | Trafficking protein particle complex subunit 4Add BLAST | 219 |
Proteomic databases
EPDi | Q9Y296 |
jPOSTi | Q9Y296 |
MassIVEi | Q9Y296 |
PaxDbi | Q9Y296 |
PeptideAtlasi | Q9Y296 |
PRIDEi | Q9Y296 |
ProteomicsDBi | 4601 85704 [Q9Y296-1] |
PTM databases
iPTMneti | Q9Y296 |
PhosphoSitePlusi | Q9Y296 |
Expressioni
Gene expression databases
Bgeei | ENSG00000196655, Expressed in right testis and 236 other tissues |
ExpressionAtlasi | Q9Y296, baseline and differential |
Genevisiblei | Q9Y296, HS |
Organism-specific databases
HPAi | ENSG00000196655, Low tissue specificity |
Interactioni
Subunit structurei
Component of the multisubunit TRAPP (transport protein particle) complex, which includes at least TRAPPC2, TRAPPC2L, TRAPPC3, TRAPPC3L, TRAPPC4, TRAPPC5, TRAPPC8, TRAPPC9, TRAPPC10, TRAPPC11 and TRAPPC12 (Probable).
Interacts with SDC2 (By similarity).
By similarity1 PublicationBinary interactionsi
Hide detailsQ9Y296
With | #Exp. | IntAct |
---|---|---|
MAPK1 [P28482] | 3 | EBI-722888,EBI-959949 |
Trappc5 [Q9CQA1] from Mus musculus. | 2 | EBI-722888,EBI-1172213 |
Protein-protein interaction databases
BioGRIDi | 119523, 50 interactors |
ComplexPortali | CPX-4749, TRAPP II complex CPX-4750, TRAPP III complex |
CORUMi | Q9Y296 |
DIPi | DIP-37871N |
IntActi | Q9Y296, 29 interactors |
STRINGi | 9606.ENSP00000436005 |
Miscellaneous databases
RNActi | Q9Y296, protein |
Structurei
Secondary structure
3D structure databases
BMRBi | Q9Y296 |
SMRi | Q9Y296 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | Q9Y296 |
Family & Domainsi
Sequence similaritiesi
Phylogenomic databases
eggNOGi | KOG3369, Eukaryota |
GeneTreei | ENSGT00940000153761 |
InParanoidi | Q9Y296 |
OMAi | GQRDGIN |
OrthoDBi | 1504863at2759 |
PhylomeDBi | Q9Y296 |
TreeFami | TF314561 |
Family and domain databases
DisProti | DP00562 |
InterProi | View protein in InterPro IPR011012, Longin-like_dom_sf IPR007233, TRAPPC |
PANTHERi | PTHR23249, PTHR23249, 1 hit |
Pfami | View protein in Pfam PF04099, Sybindin, 1 hit |
SMARTi | View protein in SMART SM01399, Sybindin, 1 hit |
SUPFAMi | SSF64356, SSF64356, 1 hit |
s (2+)i Sequence
Sequence statusi: Complete.
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 2 described isoforms and 6 potential isoforms that are computationally mapped.Show allAlign All
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MAIFSVYVVN KAGGLIYQLD SYAPRAEAEK TFSYPLDLLL KLHDERVLVA
60 70 80 90 100
FGQRDGIRVG HAVLAINGMD VNGRYTADGK EVLEYLGNPA NYPVSIRFGR
110 120 130 140 150
PRLTSNEKLM LASMFHSLFA IGSQLSPEQG SSGIEMLETD TFKLHCYQTL
160 170 180 190 200
TGIKFVVLAD PRQAGIDSLL RKIYEIYSDF ALKNPFYSLE MPIRCELFDQ
210
NLKLALEVAE KAGTFGPGS
Computationally mapped potential isoform sequencesi
There are 6 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketE9PN70 | E9PN70_HUMAN | Trafficking protein particle comple... | TRAPPC4 | 257 | Annotation score: | ||
E9PKS9 | E9PKS9_HUMAN | Trafficking protein particle comple... | TRAPPC4 | 126 | Annotation score: | ||
E9PQE8 | E9PQE8_HUMAN | Trafficking protein particle comple... | TRAPPC4 | 176 | Annotation score: | ||
J3KP27 | J3KP27_HUMAN | Trafficking protein particle comple... | TRAPPC4 | 181 | Annotation score: | ||
G3V1A0 | G3V1A0_HUMAN | Trafficking protein particle comple... | TRAPPC4 hCG_38438 | 117 | Annotation score: | ||
G5EA23 | G5EA23_HUMAN | Trafficking protein particle comple... | TRAPPC4 hCG_38438 | 126 | Annotation score: |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_052397 | 78 | D → A. Corresponds to variant dbSNP:rs11640Ensembl. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_056348 | 81 – 134 | Missing in isoform 2. 1 PublicationAdd BLAST | 54 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF105025 mRNA Translation: AAF21897.1 AF078862 mRNA Translation: AAD44494.1 AF161520 mRNA Translation: AAF29135.1 AF151862 mRNA Translation: AAD34099.1 AK290520 mRNA Translation: BAF83209.1 AK297422 mRNA Translation: BAG59853.1 AP003392 Genomic DNA No translation available. CH471065 Genomic DNA Translation: EAW67430.1 BC010866 mRNA Translation: AAH10866.1 |
CCDSi | CCDS81633.1 [Q9Y296-2] CCDS8407.1 [Q9Y296-1] |
RefSeqi | NP_001305415.1, NM_001318486.1 NP_001305417.1, NM_001318488.1 NP_001305418.1, NM_001318489.1 [Q9Y296-2] NP_001305419.1, NM_001318490.1 NP_001305421.1, NM_001318492.1 NP_001305423.1, NM_001318494.1 NP_057230.1, NM_016146.5 [Q9Y296-1] |
Genome annotation databases
Ensembli | ENST00000434101; ENSP00000405033; ENSG00000196655 [Q9Y296-2] ENST00000533632; ENSP00000436005; ENSG00000196655 [Q9Y296-1] ENST00000629243; ENSP00000487467; ENSG00000280495 [Q9Y296-1] ENST00000629713; ENSP00000486496; ENSG00000280495 [Q9Y296-2] |
GeneIDi | 51399 |
KEGGi | hsa:51399 |
UCSCi | uc010ryo.4, human [Q9Y296-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF105025 mRNA Translation: AAF21897.1 AF078862 mRNA Translation: AAD44494.1 AF161520 mRNA Translation: AAF29135.1 AF151862 mRNA Translation: AAD34099.1 AK290520 mRNA Translation: BAF83209.1 AK297422 mRNA Translation: BAG59853.1 AP003392 Genomic DNA No translation available. CH471065 Genomic DNA Translation: EAW67430.1 BC010866 mRNA Translation: AAH10866.1 |
CCDSi | CCDS81633.1 [Q9Y296-2] CCDS8407.1 [Q9Y296-1] |
RefSeqi | NP_001305415.1, NM_001318486.1 NP_001305417.1, NM_001318488.1 NP_001305418.1, NM_001318489.1 [Q9Y296-2] NP_001305419.1, NM_001318490.1 NP_001305421.1, NM_001318492.1 NP_001305423.1, NM_001318494.1 NP_057230.1, NM_016146.5 [Q9Y296-1] |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
2J3T | X-ray | 2.40 | D | 1-219 | [»] | |
2JSN | NMR | - | A | 19-106 | [»] | |
2ZMV | X-ray | 2.80 | A/B | 1-219 | [»] | |
BMRBi | Q9Y296 | |||||
SMRi | Q9Y296 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 119523, 50 interactors |
ComplexPortali | CPX-4749, TRAPP II complex CPX-4750, TRAPP III complex |
CORUMi | Q9Y296 |
DIPi | DIP-37871N |
IntActi | Q9Y296, 29 interactors |
STRINGi | 9606.ENSP00000436005 |
Chemistry databases
DrugBanki | DB08342, S-palmitoyl-L-cysteine |
PTM databases
iPTMneti | Q9Y296 |
PhosphoSitePlusi | Q9Y296 |
Genetic variation databases
BioMutai | TRAPPC4 |
DMDMi | 20178121 |
Proteomic databases
EPDi | Q9Y296 |
jPOSTi | Q9Y296 |
MassIVEi | Q9Y296 |
PaxDbi | Q9Y296 |
PeptideAtlasi | Q9Y296 |
PRIDEi | Q9Y296 |
ProteomicsDBi | 4601 85704 [Q9Y296-1] |
Protocols and materials databases
Antibodypediai | 32564, 288 antibodies |
DNASUi | 51399 |
Genome annotation databases
Ensembli | ENST00000434101; ENSP00000405033; ENSG00000196655 [Q9Y296-2] ENST00000533632; ENSP00000436005; ENSG00000196655 [Q9Y296-1] ENST00000629243; ENSP00000487467; ENSG00000280495 [Q9Y296-1] ENST00000629713; ENSP00000486496; ENSG00000280495 [Q9Y296-2] |
GeneIDi | 51399 |
KEGGi | hsa:51399 |
UCSCi | uc010ryo.4, human [Q9Y296-1] |
Organism-specific databases
CTDi | 51399 |
DisGeNETi | 51399 |
GeneCardsi | TRAPPC4 |
HGNCi | HGNC:19943, TRAPPC4 |
HPAi | ENSG00000196655, Low tissue specificity |
MalaCardsi | TRAPPC4 |
MIMi | 610971, gene 618741, phenotype |
neXtProti | NX_Q9Y296 |
OpenTargetsi | ENSG00000196655 |
Orphaneti | 528084, Non-specific syndromic intellectual disability |
PharmGKBi | PA134906910 |
VEuPathDBi | HostDB:ENSG00000196655.9 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG3369, Eukaryota |
GeneTreei | ENSGT00940000153761 |
InParanoidi | Q9Y296 |
OMAi | GQRDGIN |
OrthoDBi | 1504863at2759 |
PhylomeDBi | Q9Y296 |
TreeFami | TF314561 |
Enzyme and pathway databases
PathwayCommonsi | Q9Y296 |
Reactomei | R-HSA-204005, COPII-mediated vesicle transport R-HSA-3000170, Syndecan interactions R-HSA-8876198, RAB GEFs exchange GTP for GDP on RABs |
Miscellaneous databases
BioGRID-ORCSi | 51399, 459 hits in 997 CRISPR screens |
ChiTaRSi | TRAPPC4, human |
EvolutionaryTracei | Q9Y296 |
GeneWikii | TRAPPC4 |
GenomeRNAii | 51399 |
Pharosi | Q9Y296, Tbio |
PROi | PR:Q9Y296 |
RNActi | Q9Y296, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000196655, Expressed in right testis and 236 other tissues |
ExpressionAtlasi | Q9Y296, baseline and differential |
Genevisiblei | Q9Y296, HS |
Family and domain databases
DisProti | DP00562 |
InterProi | View protein in InterPro IPR011012, Longin-like_dom_sf IPR007233, TRAPPC |
PANTHERi | PTHR23249, PTHR23249, 1 hit |
Pfami | View protein in Pfam PF04099, Sybindin, 1 hit |
SMARTi | View protein in SMART SM01399, Sybindin, 1 hit |
SUPFAMi | SSF64356, SSF64356, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | TPPC4_HUMAN | |
Accessioni | Q9Y296Primary (citable) accession number: Q9Y296 Secondary accession number(s): A8K3A5, B4DME1 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | April 16, 2002 |
Last sequence update: | November 1, 1999 | |
Last modified: | April 7, 2021 | |
This is version 176 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- Human chromosome 11
Human chromosome 11: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families