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UniProtKB - Q9Y296 (TPPC4_HUMAN)

Entry version 172 (12 Aug 2020)
Sequence version 1 (01 Nov 1999)
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Protein

Trafficking protein particle complex subunit 4

Gene

TRAPPC4

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Core component of the TRAPP complexes which has a function of guanine nucleotide exchange factor activity for Rab1 GTPase (Probable). Plays a role in vesicular transport from endoplasmic reticulum to Golgi and autophagy (PubMed:31794024). May play a role in dendrite postsynaptic membrane trafficking (By similarity).By similarity1 Publication1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processER-Golgi transport, Transport

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		Q9Y296

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-HSA-204005, COPII-mediated vesicle transport
R-HSA-3000170, Syndecan interactions
R-HSA-8876198, RAB GEFs exchange GTP for GDP on RABs

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Trafficking protein particle complex subunit 4Curated
Alternative name(s):
Hematopoietic stem/progenitor cell protein 172
SynbindinBy similarity
TRS23 homolog
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:TRAPPC4Imported
Synonyms:SBDNBy similarity
ORF Names:CGI-104, HSPC172, PTD009
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 11

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:19943, TRAPPC4

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		610971, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_Q9Y296

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell junction, Cell membrane, Endoplasmic reticulum, Golgi apparatus, Membrane, Postsynaptic cell membrane, Synapse

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the 'Pathology and Biotech' section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Neurodevelopmental disorder with epilepsy, spasticity, and brain atrophy (NEDESBA)1 Publication
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionAn autosomal recessive disorder characterized by severely impaired global development apparent soon after birth, early-onset seizures, lack of psychomotor development, spastic quadriparesis, progressive cortical and cerebellar atrophy, and dysmorphic features, including microcephaly. Death in childhood may occur.
Related information in OMIM

Organism-specific databases

DisGeNET

More...DisGeNETi		51399
MIMi618741, phenotype

Open Targets

More...OpenTargetsi		ENSG00000196655

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA134906910

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		Q9Y296, Tbio

Chemistry databases

Drug and drug target database

More...DrugBanki		DB08342, S-palmitoyl-L-cysteine

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		TRAPPC4

Domain mapping of disease mutations (DMDM)

More...DMDMi		20178121

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002115691 – 219Trafficking protein particle complex subunit 4Add BLAST219

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		Q9Y296

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		Q9Y296

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		Q9Y296

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q9Y296

PeptideAtlas

More...PeptideAtlasi		Q9Y296

PRoteomics IDEntifications database

More...PRIDEi		Q9Y296

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		4601
85704 [Q9Y296-1]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q9Y296

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q9Y296

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000196655, Expressed in right testis and 236 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		Q9Y296, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q9Y296, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000196655, Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Component of the multisubunit TRAPP (transport protein particle) complex, which includes at least TRAPPC2, TRAPPC2L, TRAPPC3, TRAPPC3L, TRAPPC4, TRAPPC5, TRAPPC8, TRAPPC9, TRAPPC10, TRAPPC11 and TRAPPC12 (Probable).

Interacts with SDC2 (By similarity).

By similarity1 Publication

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		119523, 47 interactors

ComplexPortal: manually curated resource of macromolecular complexes

More...ComplexPortali		CPX-4749, TRAPP II complex
CPX-4750, TRAPP III complex

CORUM comprehensive resource of mammalian protein complexes

More...CORUMi		Q9Y296

Database of interacting proteins

More...DIPi		DIP-37871N

Protein interaction database and analysis system

More...IntActi		Q9Y296, 29 interactors

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000436005

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		Q9Y296, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1219
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q9Y296

Database of comparative protein structure models

More...ModBasei		Search...

Protein Data Bank in Europe - Knowledge Base

More...PDBe-KBi		Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...EvolutionaryTracei		Q9Y296

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the TRAPP small subunits family. TRAPPC4 subfamily.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG3369, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00940000153761

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q9Y296

KEGG Orthology (KO)

More...KOi		K20303

Identification of Orthologs from Complete Genome Data

More...OMAi		GQRDGIN

Database of Orthologous Groups

More...OrthoDBi		1504863at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q9Y296

TreeFam database of animal gene trees

More...TreeFami		TF314561

Family and domain databases

Database of protein disorder

More...DisProti		DP00562

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR011012, Longin-like_dom_sf
IPR007233, TRAPPC

The PANTHER Classification System

More...PANTHERi		PTHR23249, PTHR23249, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF04099, Sybindin, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM01399, Sybindin, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF64356, SSF64356, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 6 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q9Y296-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MAIFSVYVVN KAGGLIYQLD SYAPRAEAEK TFSYPLDLLL KLHDERVLVA 
        60         70         80         90        100
FGQRDGIRVG HAVLAINGMD VNGRYTADGK EVLEYLGNPA NYPVSIRFGR 
       110        120        130        140        150
PRLTSNEKLM LASMFHSLFA IGSQLSPEQG SSGIEMLETD TFKLHCYQTL 
       160        170        180        190        200
TGIKFVVLAD PRQAGIDSLL RKIYEIYSDF ALKNPFYSLE MPIRCELFDQ 
       210 
NLKLALEVAE KAGTFGPGS
Length:219
Mass (Da):24,340
Last modified:November 1, 1999 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iC6ADE525B7CFB731
GO
Isoform 2 (identifier: Q9Y296-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     81-134: Missing.

Show »
Length:165
Mass (Da):18,446
Checksum:i9ED57477C1259464
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 6 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E9PQE8E9PQE8_HUMAN
Trafficking protein particle comple...
TRAPPC4
176Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E9PKS9E9PKS9_HUMAN
Trafficking protein particle comple...
TRAPPC4
126Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
J3KP27J3KP27_HUMAN
Trafficking protein particle comple...
TRAPPC4
181Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E9PN70E9PN70_HUMAN
Trafficking protein particle comple...
TRAPPC4
257Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
G5EA23G5EA23_HUMAN
Trafficking protein particle comple...
TRAPPC4 hCG_38438
126Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
G3V1A0G3V1A0_HUMAN
Trafficking protein particle comple...
TRAPPC4 hCG_38438
117Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_05239778D → A. Corresponds to variant dbSNP:rs11640Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_05634881 – 134Missing in isoform 2. 1 PublicationAdd BLAST54

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AF105025 mRNA Translation: AAF21897.1
AF078862 mRNA Translation: AAD44494.1
AF161520 mRNA Translation: AAF29135.1
AF151862 mRNA Translation: AAD34099.1
AK290520 mRNA Translation: BAF83209.1
AK297422 mRNA Translation: BAG59853.1
AP003392 Genomic DNA No translation available.
CH471065 Genomic DNA Translation: EAW67430.1
BC010866 mRNA Translation: AAH10866.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS81633.1 [Q9Y296-2]
CCDS8407.1 [Q9Y296-1]

NCBI Reference Sequences

More...RefSeqi		NP_001305415.1, NM_001318486.1
NP_001305417.1, NM_001318488.1
NP_001305418.1, NM_001318489.1 [Q9Y296-2]
NP_001305419.1, NM_001318490.1
NP_001305421.1, NM_001318492.1
NP_001305423.1, NM_001318494.1
NP_057230.1, NM_016146.5 [Q9Y296-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000434101; ENSP00000405033; ENSG00000196655 [Q9Y296-2]
ENST00000533632; ENSP00000436005; ENSG00000196655 [Q9Y296-1]
ENST00000629243; ENSP00000487467; ENSG00000280495 [Q9Y296-1]
ENST00000629713; ENSP00000486496; ENSG00000280495 [Q9Y296-2]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		51399

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:51399

UCSC genome browser

More...UCSCi		uc010ryo.4, human [Q9Y296-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF105025 mRNA Translation: AAF21897.1
AF078862 mRNA Translation: AAD44494.1
AF161520 mRNA Translation: AAF29135.1
AF151862 mRNA Translation: AAD34099.1
AK290520 mRNA Translation: BAF83209.1
AK297422 mRNA Translation: BAG59853.1
AP003392 Genomic DNA No translation available.
CH471065 Genomic DNA Translation: EAW67430.1
BC010866 mRNA Translation: AAH10866.1
CCDSiCCDS81633.1 [Q9Y296-2]
CCDS8407.1 [Q9Y296-1]
RefSeqiNP_001305415.1, NM_001318486.1
NP_001305417.1, NM_001318488.1
NP_001305418.1, NM_001318489.1 [Q9Y296-2]
NP_001305419.1, NM_001318490.1
NP_001305421.1, NM_001318492.1
NP_001305423.1, NM_001318494.1
NP_057230.1, NM_016146.5 [Q9Y296-1]

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...PDBei

Protein Data Bank RCSB

More...RCSB PDBi

Protein Data Bank Japan

More...PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2J3TX-ray2.40D1-219[»]
2JSNNMR-A19-106[»]
2ZMVX-ray2.80A/B1-219[»]
SMRiQ9Y296
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi119523, 47 interactors
ComplexPortaliCPX-4749, TRAPP II complex
CPX-4750, TRAPP III complex
CORUMiQ9Y296
DIPiDIP-37871N
IntActiQ9Y296, 29 interactors
STRINGi9606.ENSP00000436005

Chemistry databases

DrugBankiDB08342, S-palmitoyl-L-cysteine

PTM databases

iPTMnetiQ9Y296
PhosphoSitePlusiQ9Y296

Polymorphism and mutation databases

BioMutaiTRAPPC4
DMDMi20178121

Proteomic databases

EPDiQ9Y296
jPOSTiQ9Y296
MassIVEiQ9Y296
PaxDbiQ9Y296
PeptideAtlasiQ9Y296
PRIDEiQ9Y296
ProteomicsDBi4601
85704 [Q9Y296-1]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		32564, 286 antibodies

The DNASU plasmid repository

More...DNASUi		51399

Genome annotation databases

EnsembliENST00000434101; ENSP00000405033; ENSG00000196655 [Q9Y296-2]
ENST00000533632; ENSP00000436005; ENSG00000196655 [Q9Y296-1]
ENST00000629243; ENSP00000487467; ENSG00000280495 [Q9Y296-1]
ENST00000629713; ENSP00000486496; ENSG00000280495 [Q9Y296-2]
GeneIDi51399
KEGGihsa:51399
UCSCiuc010ryo.4, human [Q9Y296-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		51399
DisGeNETi51399

GeneCards: human genes, protein and diseases

More...GeneCardsi		TRAPPC4
HGNCiHGNC:19943, TRAPPC4
HPAiENSG00000196655, Low tissue specificity
MIMi610971, gene
618741, phenotype
neXtProtiNX_Q9Y296
OpenTargetsiENSG00000196655
PharmGKBiPA134906910

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG3369, Eukaryota
GeneTreeiENSGT00940000153761
InParanoidiQ9Y296
KOiK20303
OMAiGQRDGIN
OrthoDBi1504863at2759
PhylomeDBiQ9Y296
TreeFamiTF314561

Enzyme and pathway databases

PathwayCommonsiQ9Y296
ReactomeiR-HSA-204005, COPII-mediated vesicle transport
R-HSA-3000170, Syndecan interactions
R-HSA-8876198, RAB GEFs exchange GTP for GDP on RABs

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		51399, 441 hits in 871 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		TRAPPC4, human
EvolutionaryTraceiQ9Y296

The Gene Wiki collection of pages on human genes and proteins

More...GeneWikii		TRAPPC4

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		51399
PharosiQ9Y296, Tbio

Protein Ontology

More...PROi		PR:Q9Y296
RNActiQ9Y296, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000196655, Expressed in right testis and 236 other tissues
ExpressionAtlasiQ9Y296, baseline and differential
GenevisibleiQ9Y296, HS

Family and domain databases

DisProtiDP00562
InterProiView protein in InterPro
IPR011012, Longin-like_dom_sf
IPR007233, TRAPPC
PANTHERiPTHR23249, PTHR23249, 1 hit
PfamiView protein in Pfam
PF04099, Sybindin, 1 hit
SMARTiView protein in SMART
SM01399, Sybindin, 1 hit
SUPFAMiSSF64356, SSF64356, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiTPPC4_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9Y296
Secondary accession number(s): A8K3A5, B4DME1
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 16, 2002
Last sequence update: November 1, 1999
Last modified: August 12, 2020
This is version 172 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Reference proteome

Documents

  1. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families
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