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Protein

Developmentally-regulated GTP-binding protein 1

Gene

DRG1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Critical regulator of cell growth under specific conditions. Implicated in differentiation and cell cycle arrest.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi71 – 78GTPPROSITE-ProRule annotation8
Nucleotide bindingi117 – 121GTPPROSITE-ProRule annotation5
Nucleotide bindingi248 – 251GTPPROSITE-ProRule annotation4

GO - Molecular functioni

  • GTP binding Source: UniProtKB-KW
  • identical protein binding Source: IntAct
  • transcription factor binding Source: ProtInc

GO - Biological processi

  • multicellular organism development Source: ProtInc
  • transcription, DNA-templated Source: ProtInc

Keywordsi

LigandGTP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Developmentally-regulated GTP-binding protein 1
Short name:
DRG-1
Alternative name(s):
Neural precursor cell expressed developmentally down-regulated protein 3
Short name:
NEDD-3
Gene namesi
Name:DRG1
Synonyms:NEDD3
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 22

Organism-specific databases

EuPathDBiHostDB:ENSG00000185721.11
HGNCiHGNC:3029 DRG1
MIMi603952 gene
neXtProtiNX_Q9Y295

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Organism-specific databases

DisGeNETi4733
OpenTargetsiENSG00000185721
PharmGKBiPA27483

Polymorphism and mutation databases

BioMutaiDRG1
DMDMi6685390

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedCombined sources
ChainiPRO_00002054242 – 367Developmentally-regulated GTP-binding protein 1Add BLAST366

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylserineCombined sources1
Modified residuei100Phosphothreonine; by STK161 Publication1

Post-translational modificationi

Sumoylated by UBE2I in response to MEKK1-mediated stimuli.1 Publication

Keywords - PTMi

Acetylation, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDiQ9Y295
MaxQBiQ9Y295
PaxDbiQ9Y295
PeptideAtlasiQ9Y295
PRIDEiQ9Y295
ProteomicsDBi85703

PTM databases

iPTMnetiQ9Y295
PhosphoSitePlusiQ9Y295
SwissPalmiQ9Y295

Expressioni

Tissue specificityi

High levels in skeletal muscle, heart, and kidney. Intermediate levels in liver, placenta and brain. Low levels in colon, thymus, spleen, small intestine, lung and leukocytes.1 Publication

Inductioni

By androgens.

Gene expression databases

BgeeiENSG00000185721
CleanExiHS_DRG1
ExpressionAtlasiQ9Y295 baseline and differential
GenevisibleiQ9Y295 HS

Organism-specific databases

HPAiHPA001218

Interactioni

Subunit structurei

Interacts (via its C-terminal) with TAL1. Interacts with ZC3H15; the interaction forms a polysomal DRG1-DFRP1/ZC3H15 complex which provides protein stability to DRG1 possibly by blocking poly-ubiquitination. Interacts with STK16; the interaction phosphorylates STK16 (By similarity).By similarity

Binary interactionsi

Show more details

GO - Molecular functioni

  • identical protein binding Source: IntAct
  • transcription factor binding Source: ProtInc

Protein-protein interaction databases

BioGridi110810, 60 interactors
IntActiQ9Y295, 47 interactors
MINTiQ9Y295
STRINGi9606.ENSP00000329715

Structurei

Secondary structure

1367
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi291 – 296Combined sources6
Beta strandi305 – 307Combined sources3
Beta strandi309 – 312Combined sources4
Helixi318 – 325Combined sources8
Turni330 – 332Combined sources3
Beta strandi333 – 340Combined sources8
Beta strandi343 – 350Combined sources8
Beta strandi358 – 362Combined sources5
Beta strandi364 – 366Combined sources3

3D structure databases

ProteinModelPortaliQ9Y295
SMRiQ9Y295
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ9Y295

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini65 – 290OBG-type GPROSITE-ProRule annotationAdd BLAST226

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni2 – 16Required for interaction with STK16Add BLAST15

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi47 – 56Poly-Gly10

Sequence similaritiesi

Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG1487 Eukaryota
COG1163 LUCA
GeneTreeiENSGT00550000075013
HOGENOMiHOG000112078
HOVERGENiHBG000948
InParanoidiQ9Y295
OMAiSAKHPGQ
OrthoDBiEOG091G0A12
PhylomeDBiQ9Y295
TreeFamiTF105677

Family and domain databases

Gene3Di3.10.20.30, 1 hit
InterProiView protein in InterPro
IPR012675 Beta-grasp_dom_sf
IPR031167 G_OBG
IPR031662 GTP-binding_2
IPR006074 GTP1-OBG_CS
IPR006073 GTP_binding_domain
IPR027417 P-loop_NTPase
IPR005225 Small_GTP-bd_dom
IPR004095 TGS
IPR012676 TGS-like
PfamiView protein in Pfam
PF01926 MMR_HSR1, 1 hit
PF16897 MMR_HSR1_Xtn, 1 hit
PF02824 TGS, 1 hit
PRINTSiPR00326 GTP1OBG
SUPFAMiSSF52540 SSF52540, 1 hit
SSF81271 SSF81271, 1 hit
TIGRFAMsiTIGR00231 small_GTP, 1 hit
PROSITEiView protein in PROSITE
PS51710 G_OBG, 1 hit
PS00905 GTP1_OBG, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9Y295-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSSTLAKIAE IEAEMARTQK NKATAHHLGL LKARLAKLRR ELITPKGGGG
60 70 80 90 100
GGPGEGFDVA KTGDARIGFV GFPSVGKSTL LSNLAGVYSE VAAYEFTTLT
110 120 130 140 150
TVPGVIRYKG AKIQLLDLPG IIEGAKDGKG RGRQVIAVAR TCNLILIVLD
160 170 180 190 200
VLKPLGHKKI IENELEGFGI RLNSKPPNIG FKKKDKGGIN LTATCPQSEL
210 220 230 240 250
DAETVKSILA EYKIHNADVT LRSDATADDL IDVVEGNRVY IPCIYVLNKI
260 270 280 290 300
DQISIEELDI IYKVPHCVPI SAHHRWNFDD LLEKIWDYLK LVRIYTKPKG
310 320 330 340 350
QLPDYTSPVV LPYSRTTVED FCMKIHKNLI KEFKYALVWG LSVKHNPQKV
360
GKDHTLEDED VIQIVKK
Length:367
Mass (Da):40,542
Last modified:November 1, 1999 - v1
Checksum:i4A177EA7C8E23005
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti91V → A in AAH20803 (PubMed:15489334).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF078103 mRNA Translation: AAD12240.1
AJ005940 mRNA Translation: CAA06775.1
CR542059 mRNA Translation: CAG46856.1
CR456488 mRNA Translation: CAG30374.1
BT007237 mRNA Translation: AAP35901.1
AK315659 mRNA Translation: BAG38025.1
AL096701 Genomic DNA No translation available.
AL096702 Genomic DNA No translation available.
CH471095 Genomic DNA Translation: EAW59976.1
BC019285 mRNA Translation: AAH19285.1
BC020803 mRNA Translation: AAH20803.1
CCDSiCCDS13897.1
RefSeqiNP_004138.1, NM_004147.3
UniGeneiHs.115242

Genome annotation databases

EnsembliENST00000331457; ENSP00000329715; ENSG00000185721
GeneIDi4733
KEGGihsa:4733
UCSCiuc003aku.4 human

Similar proteinsi

Entry informationi

Entry nameiDRG1_HUMAN
AccessioniPrimary (citable) accession number: Q9Y295
Secondary accession number(s): B2RDS8
, Q6FGP8, Q8WW69, Q9UGF2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: November 1, 1999
Last modified: July 18, 2018
This is version 173 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 22
    Human chromosome 22: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families

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