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Protein

28S ribosomal protein S33, mitochondrial

Gene

MRPS33

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  • structural constituent of ribosome Source: UniProtKB

GO - Biological processi

Keywordsi

Molecular functionRibonucleoprotein, Ribosomal protein

Enzyme and pathway databases

ReactomeiR-HSA-5368286 Mitochondrial translation initiation
R-HSA-5389840 Mitochondrial translation elongation
R-HSA-5419276 Mitochondrial translation termination

Names & Taxonomyi

Protein namesi
Recommended name:
28S ribosomal protein S33, mitochondrial
Short name:
MRP-S33
Short name:
S33mt
Alternative name(s):
Mitochondrial small ribosomal subunit protein mS331 Publication
Gene namesi
Name:MRPS33
ORF Names:CGI-139, PTD003
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 7

Organism-specific databases

EuPathDBiHostDB:ENSG00000090263.15
HGNCiHGNC:16634 MRPS33
MIMi611993 gene
neXtProtiNX_Q9Y291

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Mitochondrion

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000090263
PharmGKBiPA31020

Polymorphism and mutation databases

BioMutaiMRPS33
DMDMi24212388

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedCombined sources
ChainiPRO_00000877272 – 10628S ribosomal protein S33, mitochondrialAdd BLAST105

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylserineCombined sources1

Keywords - PTMi

Acetylation

Proteomic databases

EPDiQ9Y291
MaxQBiQ9Y291
PaxDbiQ9Y291
PeptideAtlasiQ9Y291
PRIDEiQ9Y291
ProteomicsDBi85701
TopDownProteomicsiQ9Y291

PTM databases

iPTMnetiQ9Y291
PhosphoSitePlusiQ9Y291

Expressioni

Gene expression databases

BgeeiENSG00000090263 Expressed in 226 organ(s), highest expression level in mucosa of transverse colon
CleanExiHS_MRPS33
ExpressionAtlasiQ9Y291 baseline and differential
GenevisibleiQ9Y291 HS

Organism-specific databases

HPAiHPA030425

Interactioni

Subunit structurei

Component of the mitochondrial small ribosomal subunit (mt-SSU). Mature mammalian 55S mitochondrial ribosomes consist of a small (28S) and a large (39S) subunit. The 28S small subunit contains a 12S ribosomal RNA (12S mt-rRNA) and 30 different proteins. The 39S large subunit contains a 16S rRNA (16S mt-rRNA), a copy of mitochondrial valine transfer RNA (mt-tRNA(Val)), which plays an integral structural role, and 52 different proteins.1 Publication

Protein-protein interaction databases

BioGridi119658, 36 interactors
CORUMiQ9Y291
IntActiQ9Y291, 13 interactors
MINTiQ9Y291
STRINGi9606.ENSP00000320567

Structurei

3D structure databases

ProteinModelPortaliQ9Y291
SMRiQ9Y291
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG4104 Eukaryota
ENOG4111X83 LUCA
GeneTreeiENSGT00390000011401
HOVERGENiHBG036129
InParanoidiQ9Y291
KOiK17411
OMAiKEVYDWY
OrthoDBiEOG091G0Y05
PhylomeDBiQ9Y291
TreeFamiTF313928

Family and domain databases

InterProiView protein in InterPro
IPR013219 Ribosomal_S27/S33_mit
PANTHERiPTHR13362 PTHR13362, 1 hit
PfamiView protein in Pfam
PF08293 MRP-S33, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

Q9Y291-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSSLSEYAFR MSRLSARLFG EVTRPTNSKS MKVVKLFSEL PLAKKKETYD
60 70 80 90 100
WYPNHHTYAE LMQTLRFLGL YRDEHQDFMD EQKRLKKLRG KEKPKKGEGK

RAAKRK
Length:106
Mass (Da):12,629
Last modified:November 1, 1999 - v1
Checksum:iE755EDAFB6AF6A46
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
C9JBY7C9JBY7_HUMAN
28S ribosomal protein S33, mitochon...
MRPS33
96Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF151897 mRNA Translation: AAD34134.1
AF078858 mRNA Translation: AAD44490.1
AC006006 Genomic DNA Translation: AAD43190.1
BC015462 mRNA Translation: AAH15462.1
CCDSiCCDS5864.1
RefSeqiNP_057155.1, NM_016071.3
NP_444263.1, NM_053035.2
UniGeneiHs.416207

Genome annotation databases

EnsembliENST00000324787; ENSP00000320567; ENSG00000090263
ENST00000393008; ENSP00000376732; ENSG00000090263
ENST00000469351; ENSP00000417287; ENSG00000090263
ENST00000496958; ENSP00000418451; ENSG00000090263
GeneIDi51650
KEGGihsa:51650
UCSCiuc003vwd.5 human

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF151897 mRNA Translation: AAD34134.1
AF078858 mRNA Translation: AAD44490.1
AC006006 Genomic DNA Translation: AAD43190.1
BC015462 mRNA Translation: AAH15462.1
CCDSiCCDS5864.1
RefSeqiNP_057155.1, NM_016071.3
NP_444263.1, NM_053035.2
UniGeneiHs.416207

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3J9Melectron microscopy3.50AZ1-106[»]
ProteinModelPortaliQ9Y291
SMRiQ9Y291
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi119658, 36 interactors
CORUMiQ9Y291
IntActiQ9Y291, 13 interactors
MINTiQ9Y291
STRINGi9606.ENSP00000320567

PTM databases

iPTMnetiQ9Y291
PhosphoSitePlusiQ9Y291

Polymorphism and mutation databases

BioMutaiMRPS33
DMDMi24212388

Proteomic databases

EPDiQ9Y291
MaxQBiQ9Y291
PaxDbiQ9Y291
PeptideAtlasiQ9Y291
PRIDEiQ9Y291
ProteomicsDBi85701
TopDownProteomicsiQ9Y291

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000324787; ENSP00000320567; ENSG00000090263
ENST00000393008; ENSP00000376732; ENSG00000090263
ENST00000469351; ENSP00000417287; ENSG00000090263
ENST00000496958; ENSP00000418451; ENSG00000090263
GeneIDi51650
KEGGihsa:51650
UCSCiuc003vwd.5 human

Organism-specific databases

CTDi51650
EuPathDBiHostDB:ENSG00000090263.15
GeneCardsiMRPS33
HGNCiHGNC:16634 MRPS33
HPAiHPA030425
MIMi611993 gene
neXtProtiNX_Q9Y291
OpenTargetsiENSG00000090263
PharmGKBiPA31020
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG4104 Eukaryota
ENOG4111X83 LUCA
GeneTreeiENSGT00390000011401
HOVERGENiHBG036129
InParanoidiQ9Y291
KOiK17411
OMAiKEVYDWY
OrthoDBiEOG091G0Y05
PhylomeDBiQ9Y291
TreeFamiTF313928

Enzyme and pathway databases

ReactomeiR-HSA-5368286 Mitochondrial translation initiation
R-HSA-5389840 Mitochondrial translation elongation
R-HSA-5419276 Mitochondrial translation termination

Miscellaneous databases

ChiTaRSiMRPS33 human
GeneWikiiMRPS33
GenomeRNAii51650
PROiPR:Q9Y291
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000090263 Expressed in 226 organ(s), highest expression level in mucosa of transverse colon
CleanExiHS_MRPS33
ExpressionAtlasiQ9Y291 baseline and differential
GenevisibleiQ9Y291 HS

Family and domain databases

InterProiView protein in InterPro
IPR013219 Ribosomal_S27/S33_mit
PANTHERiPTHR13362 PTHR13362, 1 hit
PfamiView protein in Pfam
PF08293 MRP-S33, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiRT33_HUMAN
AccessioniPrimary (citable) accession number: Q9Y291
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 19, 2002
Last sequence update: November 1, 1999
Last modified: November 7, 2018
This is version 122 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Ribosomal proteins
    Ribosomal proteins families and list of entries
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  5. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
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