UniProtKB - Q9Y291 (RT33_HUMAN)
28S ribosomal protein S33, mitochondrial
MRPS33
Functioni
GO - Molecular functioni
- structural constituent of ribosome Source: UniProtKB
GO - Biological processi
- translation Source: UniProtKB
Keywordsi
Molecular function | Ribonucleoprotein, Ribosomal protein |
Enzyme and pathway databases
PathwayCommonsi | Q9Y291 |
Reactomei | R-HSA-5368286, Mitochondrial translation initiation R-HSA-5389840, Mitochondrial translation elongation R-HSA-5419276, Mitochondrial translation termination |
SignaLinki | Q9Y291 |
SIGNORi | Q9Y291 |
Names & Taxonomyi
Protein namesi | Recommended name: 28S ribosomal protein S33, mitochondrialShort name: MRP-S33 Short name: S33mt Alternative name(s): Mitochondrial small ribosomal subunit protein mS331 Publication |
Gene namesi | Name:MRPS33 ORF Names:CGI-139, PTD003 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:16634, MRPS33 |
MIMi | 611993, gene |
neXtProti | NX_Q9Y291 |
VEuPathDBi | HostDB:ENSG00000090263 |
Subcellular locationi
Mitochondrion
- Mitochondrion 1 Publication
Mitochondrion
- mitochondrial inner membrane Source: Reactome
- mitochondrial small ribosomal subunit Source: UniProtKB
- mitochondrion Source: GO_Central
Keywords - Cellular componenti
MitochondrionPathology & Biotechi
Organism-specific databases
DisGeNETi | 51650 |
OpenTargetsi | ENSG00000090263 |
PharmGKBi | PA31020 |
Miscellaneous databases
Pharosi | Q9Y291, Tdark |
Genetic variation databases
BioMutai | MRPS33 |
DMDMi | 24212388 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Initiator methioninei | RemovedCombined sources | |||
ChainiPRO_0000087727 | 2 – 106 | 28S ribosomal protein S33, mitochondrialAdd BLAST | 105 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 2 | N-acetylserineCombined sources | 1 |
Keywords - PTMi
AcetylationProteomic databases
EPDi | Q9Y291 |
jPOSTi | Q9Y291 |
MassIVEi | Q9Y291 |
MaxQBi | Q9Y291 |
PaxDbi | Q9Y291 |
PeptideAtlasi | Q9Y291 |
PRIDEi | Q9Y291 |
ProteomicsDBi | 85701 |
TopDownProteomicsi | Q9Y291 |
PTM databases
iPTMneti | Q9Y291 |
PhosphoSitePlusi | Q9Y291 |
Expressioni
Gene expression databases
Bgeei | ENSG00000090263, Expressed in skeletal muscle tissue and 239 other tissues |
ExpressionAtlasi | Q9Y291, baseline and differential |
Genevisiblei | Q9Y291, HS |
Organism-specific databases
HPAi | ENSG00000090263, Low tissue specificity |
Interactioni
Subunit structurei
Component of the mitochondrial small ribosomal subunit (mt-SSU). Mature mammalian 55S mitochondrial ribosomes consist of a small (28S) and a large (39S) subunit. The 28S small subunit contains a 12S ribosomal RNA (12S mt-rRNA) and 30 different proteins. The 39S large subunit contains a 16S rRNA (16S mt-rRNA), a copy of mitochondrial valine transfer RNA (mt-tRNA(Val)), which plays an integral structural role, and 52 different proteins.
1 PublicationProtein-protein interaction databases
BioGRIDi | 119658, 144 interactors |
ComplexPortali | CPX-5225, 28S mitochondrial small ribosomal subunit |
CORUMi | Q9Y291 |
IntActi | Q9Y291, 40 interactors |
MINTi | Q9Y291 |
STRINGi | 9606.ENSP00000376732 |
Miscellaneous databases
RNActi | Q9Y291, protein |
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 82 – 106 | DisorderedSequence analysisAdd BLAST | 25 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 88 – 106 | Basic residuesSequence analysisAdd BLAST | 19 |
Sequence similaritiesi
Phylogenomic databases
eggNOGi | KOG4104, Eukaryota |
GeneTreei | ENSGT00390000011401 |
InParanoidi | Q9Y291 |
OMAi | VYDWYPP |
OrthoDBi | 1612570at2759 |
PhylomeDBi | Q9Y291 |
TreeFami | TF313928 |
Family and domain databases
InterProi | View protein in InterPro IPR013219, Ribosomal_S27/S33_mit |
PANTHERi | PTHR13362, PTHR13362, 1 hit |
Pfami | View protein in Pfam PF08293, MRP-S33, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All
10 20 30 40 50
MSSLSEYAFR MSRLSARLFG EVTRPTNSKS MKVVKLFSEL PLAKKKETYD
60 70 80 90 100
WYPNHHTYAE LMQTLRFLGL YRDEHQDFMD EQKRLKKLRG KEKPKKGEGK
RAAKRK
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketC9JBY7 | C9JBY7_HUMAN | 28S ribosomal protein S33, mitochon... | MRPS33 | 96 | Annotation score: |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF151897 mRNA Translation: AAD34134.1 AF078858 mRNA Translation: AAD44490.1 AC006006 Genomic DNA Translation: AAD43190.1 BC015462 mRNA Translation: AAH15462.1 |
CCDSi | CCDS5864.1 |
RefSeqi | NP_057155.1, NM_016071.3 NP_444263.1, NM_053035.2 |
Genome annotation databases
Ensembli | ENST00000324787; ENSP00000320567; ENSG00000090263 ENST00000393008; ENSP00000376732; ENSG00000090263 ENST00000469351; ENSP00000417287; ENSG00000090263 ENST00000496958; ENSP00000418451; ENSG00000090263 |
GeneIDi | 51650 |
KEGGi | hsa:51650 |
MANE-Selecti | ENST00000324787.10; ENSP00000320567.5; NM_053035.3; NP_444263.1 |
UCSCi | uc003vwd.5, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF151897 mRNA Translation: AAD34134.1 AF078858 mRNA Translation: AAD44490.1 AC006006 Genomic DNA Translation: AAD43190.1 BC015462 mRNA Translation: AAH15462.1 |
CCDSi | CCDS5864.1 |
RefSeqi | NP_057155.1, NM_016071.3 NP_444263.1, NM_053035.2 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
3J9M | electron microscopy | 3.50 | AZ | 1-106 | [»] | |
6NU2 | electron microscopy | 3.90 | AZ | 5-91 | [»] | |
6NU3 | electron microscopy | 4.40 | AZ | 1-106 | [»] | |
6RW4 | electron microscopy | 2.97 | Z | 1-106 | [»] | |
6RW5 | electron microscopy | 3.14 | Z | 1-106 | [»] | |
6VLZ | electron microscopy | 2.97 | AZ | 1-106 | [»] | |
6VMI | electron microscopy | 2.96 | AZ | 1-106 | [»] | |
6ZM5 | electron microscopy | 2.89 | AZ | 1-106 | [»] | |
6ZM6 | electron microscopy | 2.59 | AZ | 1-106 | [»] | |
6ZS9 | electron microscopy | 4.00 | AZ | 1-106 | [»] | |
6ZSA | electron microscopy | 4.00 | AZ | 1-106 | [»] | |
6ZSB | electron microscopy | 4.50 | AZ | 1-106 | [»] | |
6ZSC | electron microscopy | 3.50 | AZ | 1-106 | [»] | |
6ZSD | electron microscopy | 3.70 | AZ | 1-106 | [»] | |
6ZSE | electron microscopy | 5.00 | AZ | 1-106 | [»] | |
6ZSG | electron microscopy | 4.00 | AZ | 1-106 | [»] | |
7A5F | electron microscopy | 4.40 | Z6 | 1-106 | [»] | |
7A5G | electron microscopy | 4.33 | Z6 | 1-106 | [»] | |
7A5I | electron microscopy | 3.70 | Z6 | 1-106 | [»] | |
7A5K | electron microscopy | 3.70 | Z6 | 1-106 | [»] | |
7L08 | electron microscopy | 3.49 | AZ | 1-106 | [»] | |
7OG4 | electron microscopy | 3.80 | AZ | 1-106 | [»] | |
SMRi | Q9Y291 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 119658, 144 interactors |
ComplexPortali | CPX-5225, 28S mitochondrial small ribosomal subunit |
CORUMi | Q9Y291 |
IntActi | Q9Y291, 40 interactors |
MINTi | Q9Y291 |
STRINGi | 9606.ENSP00000376732 |
PTM databases
iPTMneti | Q9Y291 |
PhosphoSitePlusi | Q9Y291 |
Genetic variation databases
BioMutai | MRPS33 |
DMDMi | 24212388 |
Proteomic databases
EPDi | Q9Y291 |
jPOSTi | Q9Y291 |
MassIVEi | Q9Y291 |
MaxQBi | Q9Y291 |
PaxDbi | Q9Y291 |
PeptideAtlasi | Q9Y291 |
PRIDEi | Q9Y291 |
ProteomicsDBi | 85701 |
TopDownProteomicsi | Q9Y291 |
Protocols and materials databases
Antibodypediai | 32470, 116 antibodies from 20 providers |
DNASUi | 51650 |
Genome annotation databases
Ensembli | ENST00000324787; ENSP00000320567; ENSG00000090263 ENST00000393008; ENSP00000376732; ENSG00000090263 ENST00000469351; ENSP00000417287; ENSG00000090263 ENST00000496958; ENSP00000418451; ENSG00000090263 |
GeneIDi | 51650 |
KEGGi | hsa:51650 |
MANE-Selecti | ENST00000324787.10; ENSP00000320567.5; NM_053035.3; NP_444263.1 |
UCSCi | uc003vwd.5, human |
Organism-specific databases
CTDi | 51650 |
DisGeNETi | 51650 |
GeneCardsi | MRPS33 |
HGNCi | HGNC:16634, MRPS33 |
HPAi | ENSG00000090263, Low tissue specificity |
MIMi | 611993, gene |
neXtProti | NX_Q9Y291 |
OpenTargetsi | ENSG00000090263 |
PharmGKBi | PA31020 |
VEuPathDBi | HostDB:ENSG00000090263 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG4104, Eukaryota |
GeneTreei | ENSGT00390000011401 |
InParanoidi | Q9Y291 |
OMAi | VYDWYPP |
OrthoDBi | 1612570at2759 |
PhylomeDBi | Q9Y291 |
TreeFami | TF313928 |
Enzyme and pathway databases
PathwayCommonsi | Q9Y291 |
Reactomei | R-HSA-5368286, Mitochondrial translation initiation R-HSA-5389840, Mitochondrial translation elongation R-HSA-5419276, Mitochondrial translation termination |
SignaLinki | Q9Y291 |
SIGNORi | Q9Y291 |
Miscellaneous databases
BioGRID-ORCSi | 51650, 139 hits in 1014 CRISPR screens |
ChiTaRSi | MRPS33, human |
GeneWikii | MRPS33 |
GenomeRNAii | 51650 |
Pharosi | Q9Y291, Tdark |
PROi | PR:Q9Y291 |
RNActi | Q9Y291, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000090263, Expressed in skeletal muscle tissue and 239 other tissues |
ExpressionAtlasi | Q9Y291, baseline and differential |
Genevisiblei | Q9Y291, HS |
Family and domain databases
InterProi | View protein in InterPro IPR013219, Ribosomal_S27/S33_mit |
PANTHERi | PTHR13362, PTHR13362, 1 hit |
Pfami | View protein in Pfam PF08293, MRP-S33, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | RT33_HUMAN | |
Accessioni | Q9Y291Primary (citable) accession number: Q9Y291 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | October 19, 2002 |
Last sequence update: | November 1, 1999 | |
Last modified: | February 23, 2022 | |
This is version 141 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- Ribosomal proteins
Ribosomal proteins families and list of entries - Human chromosome 7
Human chromosome 7: entries, gene names and cross-references to MIM - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families