MRPS33

Functionⁱ

GO - Molecular functionⁱ

structural constituent of ribosome
Source: UniProtKB
Non-traceable author statementⁱ
- 11279123

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

mitochondrial translational elongation Source: Reactome
mitochondrial translational termination Source: Reactome
translation
Source: UniProtKB
Non-traceable author statementⁱ
- 11279123

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Ribonucleoprotein, Ribosomal protein

Molecular function

Ribonucleoprotein, Ribosomal protein

Enzyme and pathway databases

Reactomeⁱ	R-HSA-5368286 Mitochondrial translation initiation R-HSA-5389840 Mitochondrial translation elongation R-HSA-5419276 Mitochondrial translation termination

Reactomeⁱ

R-HSA-5368286 Mitochondrial translation initiation
R-HSA-5389840 Mitochondrial translation elongation
R-HSA-5419276 Mitochondrial translation termination

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: 28S ribosomal protein S33, mitochondrial Short name: MRP-S33 Short name: S33mt Alternative name(s): Mitochondrial small ribosomal subunit protein mS331 Publication
Gene namesⁱ	Name:MRPS33 ORF Names:CGI-139, PTD003
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 7

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000090263.15
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:16634 MRPS33
MIMⁱ	611993 gene
neXtProtⁱ	NX_Q9Y291

Keywords - Cellular componentⁱ

Mitochondrion

Pathology & Biotechⁱ

Organism-specific databases

Open Targets More...OpenTargetsⁱ	ENSG00000090263
PharmGKBⁱ	PA31020

Polymorphism and mutation databases

BioMutaⁱ	MRPS33
DMDMⁱ	24212388

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Initiator methionineⁱ		RemovedCombined sources
ChainⁱPRO_0000087727	2 – 106	28S ribosomal protein S33, mitochondrialAdd BLAST		105

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Modified residueⁱ	2	N-acetylserineCombined sources		1

Keywords - PTMⁱ

Acetylation

Proteomic databases

EPDⁱ	Q9Y291
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	Q9Y291
PaxDbⁱ	Q9Y291
PeptideAtlas More...PeptideAtlasⁱ	Q9Y291
PRIDEⁱ	Q9Y291
ProteomicsDBⁱ	85701
TopDownProteomicsⁱ	Q9Y291

PTM databases

iPTMnetⁱ	Q9Y291
PhosphoSitePlusⁱ	Q9Y291

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSG00000090263 Expressed in 226 organ(s), highest expression level in mucosa of transverse colon
CleanExⁱ	HS_MRPS33
ExpressionAtlasⁱ	Q9Y291 baseline and differential
Genevisibleⁱ	Q9Y291 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA030425

HPAⁱ

HPA030425

Interactionⁱ

Subunit structureⁱ

Component of the mitochondrial small ribosomal subunit (mt-SSU). Mature mammalian 55S mitochondrial ribosomes consist of a small (28S) and a large (39S) subunit. The 28S small subunit contains a 12S ribosomal RNA (12S mt-rRNA) and 30 different proteins. The 39S large subunit contains a 16S rRNA (16S mt-rRNA), a copy of mitochondrial valine transfer RNA (mt-tRNA(Val)), which plays an integral structural role, and 52 different proteins.1 Publication

Protein-protein interaction databases

BioGridⁱ	119658, 36 interactors
CORUMⁱ	Q9Y291
IntActⁱ	Q9Y291, 13 interactors
Molecular INTeraction database More...MINTⁱ	Q9Y291
STRINGⁱ	9606.ENSP00000320567

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q9Y291
SMRⁱ	Q9Y291
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Sequence similaritiesⁱ

Belongs to the mitochondrion-specific ribosomal protein mS33 family.Curated

Phylogenomic databases

eggNOGⁱ	KOG4104 Eukaryota ENOG4111X83 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00390000011401
HOVERGENⁱ	HBG036129
InParanoidⁱ	Q9Y291
KEGG Orthology (KO) More...KOⁱ	K17411
OMAⁱ	KEVYDWY
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0Y05
PhylomeDBⁱ	Q9Y291
TreeFamⁱ	TF313928

Family and domain databases

InterProⁱ	View protein in InterPro IPR013219 Ribosomal_S27/S33_mit
PANTHERⁱ	PTHR13362 PTHR13362, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF08293 MRP-S33, 1 hit

Sequence (1+)ⁱ

Sequence statusⁱ: Complete.

Sequence processingⁱ: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show all Align All

Q9Y291-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MSSLSEYAFR MSRLSARLFG EVTRPTNSKS MKVVKLFSEL PLAKKKETYD 
        60         70         80         90        100
WYPNHHTYAE LMQTLRFLGL YRDEHQDFMD EQKRLKKLRG KEKPKKGEGK 

RAAKRK

Length:106

Mass (Da):12,629

Last modified:November 1, 1999 - v1

Checksum:ⁱE755EDAFB6AF6A46

GO

Computationally mapped potential isoform sequencesⁱ

There is 1 potential isoform mapped to this entry.BLAST Align Show all Add to basket

	Entry	Entry name		Protein names	Gene names	Length	Annotation

	C9JBY7	C9JBY7_HUMAN		28S ribosomal protein S33, mitochon... 28S ribosomal protein S33, mitochondrial	MRPS33	96	Annotation score:

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AF151897 mRNA Translation: AAD34134.1 AF078858 mRNA Translation: AAD44490.1 AC006006 Genomic DNA Translation: AAD43190.1 BC015462 mRNA Translation: AAH15462.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS5864.1
NCBI Reference Sequences More...RefSeqⁱ	NP_057155.1, NM_016071.3 NP_444263.1, NM_053035.2
UniGeneⁱ	Hs.416207

Genome annotation databases

Ensemblⁱ	ENST00000324787; ENSP00000320567; ENSG00000090263 ENST00000393008; ENSP00000376732; ENSG00000090263 ENST00000469351; ENSP00000417287; ENSG00000090263 ENST00000496958; ENSP00000418451; ENSG00000090263
GeneIDⁱ	51650
KEGGⁱ	hsa:51650
UCSC genome browser More...UCSCⁱ	uc003vwd.5 human

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
Q9Y291	Mitochondrial ribosomal protein S33		HUMAN		106	UniRef100_Q9Y291
MRPS33 isoform 1		PANTR		106
Uncharacterized protein		PANPA		106
Mitochondrial ribosomal protein S33		GORGO		106
28S ribosomal protein S33, mitochondrial		HUMAN		96
+1

Protein	Similar proteins		Species	Score	Length	Source
Q9Y291	Mitochondrial ribosomal protein S33		HUMAN		106	UniRef90_Q9Y291
MRPS33 isoform 1		PANTR		106
Uncharacterized protein		PANPA		106
Mitochondrial ribosomal protein S33		GORGO		106
28S ribosomal protein S33, mitochondrial		MACMU		106
+17

Protein	Similar proteins		Species	Score	Length	Source
Q9Y291	Mitochondrial ribosomal protein S33		HUMAN		106	UniRef50_Q9Y291
MRPS33 isoform 1		PANTR		106
Uncharacterized protein		PANPA		106
Mitochondrial ribosomal protein S33		GORGO		106
Uncharacterized protein		NOMLE		106
+82

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AF151897 mRNA Translation: AAD34134.1 AF078858 mRNA Translation: AAD44490.1 AC006006 Genomic DNA Translation: AAD43190.1 BC015462 mRNA Translation: AAH15462.1
CCDSⁱ	CCDS5864.1
RefSeqⁱ	NP_057155.1, NM_016071.3 NP_444263.1, NM_053035.2
UniGeneⁱ	Hs.416207

3D structure databases

Select the link destinations: Protein Data Bank Europe More...PDBeⁱ Protein Data Bank RCSB More...RCSB PDBⁱ Protein Data Bank Japan More...PDBjⁱ Links Updated	PDB entry	Method	Resolution (Å)	Chain	Positions	PDBsum
	3J9M	electron microscopy	3.50	AZ	1-106	[»]
ProteinModelPortalⁱ	Q9Y291
SMRⁱ	Q9Y291
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	119658, 36 interactors
CORUMⁱ	Q9Y291
IntActⁱ	Q9Y291, 13 interactors
MINTⁱ	Q9Y291
STRINGⁱ	9606.ENSP00000320567

PTM databases

iPTMnetⁱ	Q9Y291
PhosphoSitePlusⁱ	Q9Y291

Polymorphism and mutation databases

BioMutaⁱ	MRPS33
DMDMⁱ	24212388

Proteomic databases

EPDⁱ	Q9Y291
MaxQBⁱ	Q9Y291
PaxDbⁱ	Q9Y291
PeptideAtlasⁱ	Q9Y291
PRIDEⁱ	Q9Y291
ProteomicsDBⁱ	85701
TopDownProteomicsⁱ	Q9Y291

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENST00000324787; ENSP00000320567; ENSG00000090263 ENST00000393008; ENSP00000376732; ENSG00000090263 ENST00000469351; ENSP00000417287; ENSG00000090263 ENST00000496958; ENSP00000418451; ENSG00000090263
GeneIDⁱ	51650
KEGGⁱ	hsa:51650
UCSCⁱ	uc003vwd.5 human

Organism-specific databases

CTDⁱ	51650
EuPathDBⁱ	HostDB:ENSG00000090263.15
GeneCardsⁱ	MRPS33
HGNCⁱ	HGNC:16634 MRPS33
HPAⁱ	HPA030425
MIMⁱ	611993 gene
neXtProtⁱ	NX_Q9Y291
OpenTargetsⁱ	ENSG00000090263
PharmGKBⁱ	PA31020
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG4104 Eukaryota ENOG4111X83 LUCA
GeneTreeⁱ	ENSGT00390000011401
HOVERGENⁱ	HBG036129
InParanoidⁱ	Q9Y291
KOⁱ	K17411
OMAⁱ	KEVYDWY
OrthoDBⁱ	EOG091G0Y05
PhylomeDBⁱ	Q9Y291
TreeFamⁱ	TF313928

Enzyme and pathway databases

Reactomeⁱ	R-HSA-5368286 Mitochondrial translation initiation R-HSA-5389840 Mitochondrial translation elongation R-HSA-5419276 Mitochondrial translation termination

Reactomeⁱ

R-HSA-5368286 Mitochondrial translation initiation
R-HSA-5389840 Mitochondrial translation elongation
R-HSA-5419276 Mitochondrial translation termination

Miscellaneous databases

ChiTaRSⁱ	MRPS33 human
GeneWikiⁱ	MRPS33
GenomeRNAiⁱ	51650
Protein Ontology More...PROⁱ	PR:Q9Y291
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000090263 Expressed in 226 organ(s), highest expression level in mucosa of transverse colon
CleanExⁱ	HS_MRPS33
ExpressionAtlasⁱ	Q9Y291 baseline and differential
Genevisibleⁱ	Q9Y291 HS

Family and domain databases

InterProⁱ	View protein in InterPro IPR013219 Ribosomal_S27/S33_mit
PANTHERⁱ	PTHR13362 PTHR13362, 1 hit
Pfamⁱ	View protein in Pfam PF08293 MRP-S33, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	RT33_HUMAN
Accessionⁱ	Q9Y291Primary (citable) accession number: Q9Y291
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	October 19, 2002
	Last sequence update:	November 1, 1999
	Last modified:	November 7, 2018
	This is version 122 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

3D-structure, Complete proteome, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
Ribosomal proteins
Ribosomal proteins families and list of entries
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
PDB cross-references
Index of Protein Data Bank (PDB) cross-references
Human chromosome 7
Human chromosome 7: entries, gene names and cross-references to MIM

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UniProtKB - Q9Y291 (RT33_HUMAN)

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28S ribosomal protein S33, mitochondrial

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Mitochondrion

Mitochondrion

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

Family and domain databases

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ