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Protein

Sodium-dependent multivitamin transporter

Gene

SLC5A6

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Transports pantothenate, biotin and lipoate in the presence of sodium.

GO - Molecular functioni

  • sodium-dependent multivitamin transmembrane transporter activity Source: GO_Central

GO - Biological processi

Keywordsi

Biological processIon transport, Sodium transport, Symport, Transport
LigandBiotin, Sodium

Enzyme and pathway databases

ReactomeiR-HSA-196780 Biotin transport and metabolism
R-HSA-199220 Vitamin B5 (pantothenate) metabolism
R-HSA-425397 Transport of vitamins, nucleosides, and related molecules

Protein family/group databases

TCDBi2.A.21.5.7 the solute:sodium symporter (sss) family

Names & Taxonomyi

Protein namesi
Recommended name:
Sodium-dependent multivitamin transporter
Short name:
Na(+)-dependent multivitamin transporter
Alternative name(s):
Solute carrier family 5 member 6
Gene namesi
Name:SLC5A6
Synonyms:SMVT
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 2

Organism-specific databases

EuPathDBiHostDB:ENSG00000138074.14
HGNCiHGNC:11041 SLC5A6
MIMi604024 gene
neXtProtiNX_Q9Y289

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei24 – 44HelicalSequence analysisAdd BLAST21
Transmembranei68 – 88HelicalSequence analysisAdd BLAST21
Transmembranei101 – 121HelicalSequence analysisAdd BLAST21
Transmembranei143 – 163HelicalSequence analysisAdd BLAST21
Transmembranei176 – 196HelicalSequence analysisAdd BLAST21
Transmembranei199 – 219HelicalSequence analysisAdd BLAST21
Transmembranei256 – 276HelicalSequence analysisAdd BLAST21
Transmembranei297 – 317HelicalSequence analysisAdd BLAST21
Transmembranei336 – 356HelicalSequence analysisAdd BLAST21
Transmembranei396 – 416HelicalSequence analysisAdd BLAST21
Transmembranei428 – 448HelicalSequence analysisAdd BLAST21
Transmembranei456 – 476HelicalSequence analysisAdd BLAST21
Transmembranei528 – 548HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi8884
OpenTargetsiENSG00000138074
PharmGKBiPA379

Chemistry databases

DrugBankiDB00121 Biotin
DB08872 gabapentin enacarbil
DB00166 Lipoic Acid

Polymorphism and mutation databases

BioMutaiSLC5A6
DMDMi229462745

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001053861 – 635Sodium-dependent multivitamin transporterAdd BLAST635

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi138N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi489N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi498N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

EPDiQ9Y289
MaxQBiQ9Y289
PaxDbiQ9Y289
PeptideAtlasiQ9Y289
PRIDEiQ9Y289
ProteomicsDBi85700

PTM databases

iPTMnetiQ9Y289
PhosphoSitePlusiQ9Y289
SwissPalmiQ9Y289

Expressioni

Gene expression databases

BgeeiENSG00000138074 Expressed in 182 organ(s), highest expression level in right lobe of liver
CleanExiHS_SLC5A6
ExpressionAtlasiQ9Y289 baseline and differential
GenevisibleiQ9Y289 HS

Organism-specific databases

HPAiHPA036958

Interactioni

Protein-protein interaction databases

BioGridi114403, 7 interactors
IntActiQ9Y289, 2 interactors
STRINGi9606.ENSP00000310208

Structurei

3D structure databases

ProteinModelPortaliQ9Y289
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG2349 Eukaryota
COG0591 LUCA
GeneTreeiENSGT00760000118955
HOGENOMiHOG000261662
HOVERGENiHBG057280
InParanoidiQ9Y289
KOiK14386
OMAiQAVFLWP
OrthoDBiEOG091G07OC
PhylomeDBiQ9Y289
TreeFamiTF316728

Family and domain databases

Gene3Di1.20.1730.10, 1 hit
InterProiView protein in InterPro
IPR038377 Na/Glc_symporter_sf
IPR001734 Na/solute_symporter
IPR018212 Na/solute_symporter_CS
PfamiView protein in Pfam
PF00474 SSF, 1 hit
TIGRFAMsiTIGR00813 sss, 1 hit
PROSITEiView protein in PROSITE
PS00456 NA_SOLUT_SYMP_1, 1 hit
PS50283 NA_SOLUT_SYMP_3, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 9 potential isoforms that are computationally mapped.Show allAlign All

Q9Y289-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSVGVSTSAP LSPTSGTSVG MSTFSIMDYV VFVLLLVLSL AIGLYHACRG
60 70 80 90 100
WGRHTVGELL MADRKMGCLP VALSLLATFQ SAVAILGVPS EIYRFGTQYW
110 120 130 140 150
FLGCCYFLGL LIPAHIFIPV FYRLHLTSAY EYLELRFNKT VRVCGTVTFI
160 170 180 190 200
FQMVIYMGVV LYAPSLALNA VTGFDLWLSV LALGIVCTVY TALGGLKAVI
210 220 230 240 250
WTDVFQTLVM FLGQLAVIIV GSAKVGGLGR VWAVASQHGR ISGFELDPDP
260 270 280 290 300
FVRHTFWTLA FGGVFMMLSL YGVNQAQVQR YLSSRTEKAA VLSCYAVFPF
310 320 330 340 350
QQVSLCVGCL IGLVMFAYYQ EYPMSIQQAQ AAPDQFVLYF VMDLLKGLPG
360 370 380 390 400
LPGLFIACLF SGSLSTISSA FNSLATVTME DLIRPWFPEF SEARAIMLSR
410 420 430 440 450
GLAFGYGLLC LGMAYISSQM GPVLQAAISI FGMVGGPLLG LFCLGMFFPC
460 470 480 490 500
ANPPGAVVGL LAGLVMAFWI GIGSIVTSMG SSMPPSPSNG SSFSLPTNLT
510 520 530 540 550
VATVTTLMPL TTFSKPTGLQ RFYSLSYLWY SAHNSTTVIV VGLIVSLLTG
560 570 580 590 600
RMRGRSLNPA TIYPVLPKLL SLLPLSCQKR LHCRSYGQDH LDTGLFPEKP
610 620 630
RNGVLGDSRD KEAMALDGTA YQGSSSTCIL QETSL
Length:635
Mass (Da):68,642
Last modified:May 5, 2009 - v2
Checksum:i52A6E40DB337134F
GO

Computationally mapped potential isoform sequencesi

There are 9 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E7EW78E7EW78_HUMAN
Sodium-dependent multivitamin trans...
SLC5A6
147Annotation score:
E7ENG0E7ENG0_HUMAN
Sodium-dependent multivitamin trans...
SLC5A6
133Annotation score:
E7ENN0E7ENN0_HUMAN
Sodium-dependent multivitamin trans...
SLC5A6
153Annotation score:
E7EMX0E7EMX0_HUMAN
Sodium-dependent multivitamin trans...
SLC5A6
193Annotation score:
E7ERE1E7ERE1_HUMAN
Sodium-dependent multivitamin trans...
SLC5A6
115Annotation score:
E7EW41E7EW41_HUMAN
Sodium-dependent multivitamin trans...
SLC5A6
78Annotation score:
E7EXC0E7EXC0_HUMAN
Sodium-dependent multivitamin trans...
SLC5A6
38Annotation score:
E7EP02E7EP02_HUMAN
Sodium-dependent multivitamin trans...
SLC5A6
58Annotation score:
Q9HD19Q9HD19_HUMAN
Sodium-dependent multivitamin trans...
SLC5A6 SMVT
27Annotation score:

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_052491481S → F4 PublicationsCorresponds to variant dbSNP:rs1395Ensembl.1
Natural variantiVAR_052492492S → N. Corresponds to variant dbSNP:rs1064845Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF116241 Genomic DNA Translation: AAD37502.1
AF069307 mRNA Translation: AAD31727.1
AF081571 mRNA Translation: AAD37481.1
AK314545 mRNA Translation: BAG37132.1
AC013403 Genomic DNA Translation: AAX93172.1
CH471053 Genomic DNA Translation: EAX00620.1
CH471053 Genomic DNA Translation: EAX00621.1
CH471053 Genomic DNA Translation: EAX00622.1
BC012806 mRNA Translation: AAH12806.1
BC015631 mRNA Translation: AAH15631.1
CCDSiCCDS1740.1
RefSeqiNP_066918.2, NM_021095.2
XP_006712191.1, XM_006712128.1
XP_006712192.1, XM_006712129.1
XP_006712193.1, XM_006712130.1
UniGeneiHs.435735

Genome annotation databases

EnsembliENST00000310574; ENSP00000310208; ENSG00000138074
ENST00000408041; ENSP00000384853; ENSG00000138074
GeneIDi8884
KEGGihsa:8884
UCSCiuc002rjd.4 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF116241 Genomic DNA Translation: AAD37502.1
AF069307 mRNA Translation: AAD31727.1
AF081571 mRNA Translation: AAD37481.1
AK314545 mRNA Translation: BAG37132.1
AC013403 Genomic DNA Translation: AAX93172.1
CH471053 Genomic DNA Translation: EAX00620.1
CH471053 Genomic DNA Translation: EAX00621.1
CH471053 Genomic DNA Translation: EAX00622.1
BC012806 mRNA Translation: AAH12806.1
BC015631 mRNA Translation: AAH15631.1
CCDSiCCDS1740.1
RefSeqiNP_066918.2, NM_021095.2
XP_006712191.1, XM_006712128.1
XP_006712192.1, XM_006712129.1
XP_006712193.1, XM_006712130.1
UniGeneiHs.435735

3D structure databases

ProteinModelPortaliQ9Y289
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi114403, 7 interactors
IntActiQ9Y289, 2 interactors
STRINGi9606.ENSP00000310208

Chemistry databases

DrugBankiDB00121 Biotin
DB08872 gabapentin enacarbil
DB00166 Lipoic Acid

Protein family/group databases

TCDBi2.A.21.5.7 the solute:sodium symporter (sss) family

PTM databases

iPTMnetiQ9Y289
PhosphoSitePlusiQ9Y289
SwissPalmiQ9Y289

Polymorphism and mutation databases

BioMutaiSLC5A6
DMDMi229462745

Proteomic databases

EPDiQ9Y289
MaxQBiQ9Y289
PaxDbiQ9Y289
PeptideAtlasiQ9Y289
PRIDEiQ9Y289
ProteomicsDBi85700

Protocols and materials databases

DNASUi8884
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000310574; ENSP00000310208; ENSG00000138074
ENST00000408041; ENSP00000384853; ENSG00000138074
GeneIDi8884
KEGGihsa:8884
UCSCiuc002rjd.4 human

Organism-specific databases

CTDi8884
DisGeNETi8884
EuPathDBiHostDB:ENSG00000138074.14
GeneCardsiSLC5A6
HGNCiHGNC:11041 SLC5A6
HPAiHPA036958
MIMi604024 gene
neXtProtiNX_Q9Y289
OpenTargetsiENSG00000138074
PharmGKBiPA379
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG2349 Eukaryota
COG0591 LUCA
GeneTreeiENSGT00760000118955
HOGENOMiHOG000261662
HOVERGENiHBG057280
InParanoidiQ9Y289
KOiK14386
OMAiQAVFLWP
OrthoDBiEOG091G07OC
PhylomeDBiQ9Y289
TreeFamiTF316728

Enzyme and pathway databases

ReactomeiR-HSA-196780 Biotin transport and metabolism
R-HSA-199220 Vitamin B5 (pantothenate) metabolism
R-HSA-425397 Transport of vitamins, nucleosides, and related molecules

Miscellaneous databases

ChiTaRSiSLC5A6 human
GeneWikiiSLC5A6
GenomeRNAii8884
PROiPR:Q9Y289
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000138074 Expressed in 182 organ(s), highest expression level in right lobe of liver
CleanExiHS_SLC5A6
ExpressionAtlasiQ9Y289 baseline and differential
GenevisibleiQ9Y289 HS

Family and domain databases

Gene3Di1.20.1730.10, 1 hit
InterProiView protein in InterPro
IPR038377 Na/Glc_symporter_sf
IPR001734 Na/solute_symporter
IPR018212 Na/solute_symporter_CS
PfamiView protein in Pfam
PF00474 SSF, 1 hit
TIGRFAMsiTIGR00813 sss, 1 hit
PROSITEiView protein in PROSITE
PS00456 NA_SOLUT_SYMP_1, 1 hit
PS50283 NA_SOLUT_SYMP_3, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiSC5A6_HUMAN
AccessioniPrimary (citable) accession number: Q9Y289
Secondary accession number(s): B2RB85, D6W549, Q969Y5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 24, 2001
Last sequence update: May 5, 2009
Last modified: November 7, 2018
This is version 144 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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