UniProtKB - Q9Y282 (ERGI3_HUMAN)
Protein
Endoplasmic reticulum-Golgi intermediate compartment protein 3
Gene
ERGIC3
Organism
Homo sapiens (Human)
Status
Functioni
Possible role in transport between endoplasmic reticulum and Golgi.By similarity
GO - Biological processi
- endoplasmic reticulum to Golgi vesicle-mediated transport Source: GO_Central
- retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum Source: GO_Central
Keywordsi
Biological process | ER-Golgi transport, Transport |
Enzyme and pathway databases
PathwayCommonsi | Q9Y282 |
SIGNORi | Q9Y282 |
Names & Taxonomyi
Protein namesi | Recommended name: Endoplasmic reticulum-Golgi intermediate compartment protein 3Alternative name(s): Serologically defined breast cancer antigen NY-BR-84 |
Gene namesi | Name:ERGIC3 Synonyms:C20orf47, ERV46, SDBCAG84 ORF Names:CGI-54, PRO0989 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:15927, ERGIC3 |
neXtProti | NX_Q9Y282 |
VEuPathDBi | HostDB:ENSG00000125991.18 |
Subcellular locationi
Golgi apparatus
- cis-Golgi network membrane 1 Publication; Multi-pass membrane protein 1 Publication
Endoplasmic reticulum
- Endoplasmic reticulum membrane 1 Publication; Multi-pass membrane protein 1 Publication
Other locations
- Endoplasmic reticulum-Golgi intermediate compartment membrane 1 Publication; Multi-pass membrane protein 1 Publication
Note: Cycles between the endoplasmic reticulum and the Golgi.
Endoplasmic reticulum
- endoplasmic reticulum Source: GO_Central
- integral component of endoplasmic reticulum membrane Source: GO_Central
Golgi apparatus
- integral component of Golgi membrane Source: GO_Central
Other locations
- COPII-coated ER to Golgi transport vesicle Source: GO_Central
- endoplasmic reticulum-Golgi intermediate compartment membrane Source: UniProtKB-SubCell
- membrane Source: UniProtKB
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 1 – 25 | CytoplasmicSequence analysisAdd BLAST | 25 | |
Transmembranei | 26 – 46 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 47 – 341 | LumenalSequence analysisAdd BLAST | 295 | |
Transmembranei | 342 – 362 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 363 – 383 | CytoplasmicSequence analysisAdd BLAST | 21 |
Keywords - Cellular componenti
Endoplasmic reticulum, Golgi apparatus, MembranePathology & Biotechi
Organism-specific databases
DisGeNETi | 51614 |
OpenTargetsi | ENSG00000125991 |
PharmGKBi | PA38050 |
Miscellaneous databases
Pharosi | Q9Y282, Tbio |
Genetic variation databases
BioMutai | ERGIC3 |
DMDMi | 37999823 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000097640 | 1 – 383 | Endoplasmic reticulum-Golgi intermediate compartment protein 3Add BLAST | 383 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 1 | N-acetylmethionineCombined sources | 1 | |
Modified residuei | 116 | PhosphoserineCombined sources | 1 | |
Glycosylationi | 241 | N-linked (GlcNAc...) asparagine1 Publication | 1 | |
Glycosylationi | 266 | N-linked (GlcNAc...) asparagineSequence analysis | 1 |
Keywords - PTMi
Acetylation, Glycoprotein, PhosphoproteinProteomic databases
EPDi | Q9Y282 |
jPOSTi | Q9Y282 |
MassIVEi | Q9Y282 |
PaxDbi | Q9Y282 |
PeptideAtlasi | Q9Y282 |
PRIDEi | Q9Y282 |
ProteomicsDBi | 85687 [Q9Y282-1] 85688 [Q9Y282-2] 85689 [Q9Y282-3] |
PTM databases
GlyGeni | Q9Y282, 3 sites, 1 O-linked glycan (1 site) |
iPTMneti | Q9Y282 |
PhosphoSitePlusi | Q9Y282 |
SwissPalmi | Q9Y282 |
Expressioni
Gene expression databases
Bgeei | ENSG00000125991, Expressed in testis and 245 other tissues |
ExpressionAtlasi | Q9Y282, baseline and differential |
Genevisiblei | Q9Y282, HS |
Organism-specific databases
HPAi | ENSG00000125991, Low tissue specificity |
Interactioni
Subunit structurei
Interacts with ERGIC1/ERGIC32.
1 PublicationBinary interactionsi
Q9Y282
Protein-protein interaction databases
BioGRIDi | 119638, 278 interactors |
IntActi | Q9Y282, 257 interactors |
MINTi | Q9Y282 |
STRINGi | 9606.ENSP00000349970 |
Miscellaneous databases
RNActi | Q9Y282, protein |
Family & Domainsi
Sequence similaritiesi
Belongs to the ERGIC family.Curated
Keywords - Domaini
Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG2667, Eukaryota |
GeneTreei | ENSGT00530000063113 |
InParanoidi | Q9Y282 |
OrthoDBi | 1318747at2759 |
PhylomeDBi | Q9Y282 |
TreeFami | TF300739 |
Family and domain databases
InterProi | View protein in InterPro IPR012936, Erv_C IPR039542, Erv_N |
Pfami | View protein in Pfam PF07970, COPIIcoated_ERV, 1 hit PF13850, ERGIC_N, 1 hit |
s (3+)i Sequence
Sequence statusi: Complete.
This entry describes 3 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 3 described isoforms and 7 potential isoforms that are computationally mapped.Show allAlign All
Isoform 1 (identifier: Q9Y282-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MEALGKLKQF DAYPKTLEDF RVKTCGGATV TIVSGLLMLL LFLSELQYYL
60 70 80 90 100
TTEVHPELYV DKSRGDKLKI NIDVLFPHMP CAYLSIDAMD VAGEQQLDVE
110 120 130 140 150
HNLFKQRLDK DGIPVSSEAE RHELGKVEVT VFDPDSLDPD RCESCYGAEA
160 170 180 190 200
EDIKCCNTCE DVREAYRRRG WAFKNPDTIE QCRREGFSQK MQEQKNEGCQ
210 220 230 240 250
VYGFLEVNKV AGNFHFAPGK SFQQSHVHVH DLQSFGLDNI NMTHYIQHLS
260 270 280 290 300
FGEDYPGIVN PLDHTNVTAP QASMMFQYFV KVVPTVYMKV DGEVLRTNQF
310 320 330 340 350
SVTRHEKVAN GLLGDQGLPG VFVLYELSPM MVKLTEKHRS FTHFLTGVCA
360 370 380
IIGGMFTVAG LIDSLIYHSA RAIQKKIDLG KTT
Computationally mapped potential isoform sequencesi
There are 7 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketH0Y5K5 | H0Y5K5_HUMAN | Endoplasmic reticulum-Golgi interme... | ERGIC3 | 397 | Annotation score: | ||
H0Y621 | H0Y621_HUMAN | Endoplasmic reticulum-Golgi interme... | ERGIC3 | 326 | Annotation score: | ||
H0Y6Z0 | H0Y6Z0_HUMAN | Endoplasmic reticulum-Golgi interme... | ERGIC3 | 157 | Annotation score: | ||
A6PVJ2 | A6PVJ2_HUMAN | ERGIC and golgi 3 | ERGIC3 RP3-477O4.12-011 | 118 | Annotation score: | ||
H0Y802 | H0Y802_HUMAN | Endoplasmic reticulum-Golgi interme... | ERGIC3 | 130 | Annotation score: | ||
A0A0C4DH46 | A0A0C4DH46_HUMAN | Endoplasmic reticulum-Golgi interme... | ERGIC3 | 123 | Annotation score: | ||
A0A1W2PPS8 | A0A1W2PPS8_HUMAN | Endoplasmic reticulum-Golgi interme... | ERGIC3 | 198 | Annotation score: |
Sequence cautioni
The sequence AAF71038 differs from that shown. Reason: Erroneous initiation.Curated
The sequence AAG48265 differs from that shown. Reason: Erroneous initiation.Curated
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 239 | N → D in BAC11054 (PubMed:14702039).Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_048939 | 113 | I → L. Corresponds to variant dbSNP:rs35505616Ensembl. | 1 | |
Natural variantiVAR_036553 | 297 | T → K in a colorectal cancer sample; somatic mutation. 1 Publication | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_008652 | 229 – 230 | VH → GE in isoform 2. 1 Publication | 2 | |
Alternative sequenceiVSP_019208 | 229 | V → VHAVEI in isoform 3. 1 Publication | 1 | |
Alternative sequenceiVSP_008653 | 231 – 383 | Missing in isoform 2. 1 PublicationAdd BLAST | 153 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF308298 mRNA Translation: AAG48265.1 Different initiation. AF151812 mRNA Translation: AAD34049.1 AK074550 mRNA Translation: BAC11054.1 AF077030 mRNA Translation: AAD27763.1 AL121586 Genomic DNA Translation: CAB89412.1 AL121586 Genomic DNA Translation: CAI42842.1 BC009765 mRNA Translation: AAH09765.1 BC014014 mRNA Translation: AAH14014.1 AF116614 mRNA Translation: AAF71038.1 Different initiation. |
CCDSi | CCDS13257.1 [Q9Y282-1] CCDS13258.1 [Q9Y282-3] |
RefSeqi | NP_057050.1, NM_015966.2 [Q9Y282-1] NP_938408.1, NM_198398.1 [Q9Y282-3] |
Genome annotation databases
Ensembli | ENST00000348547; ENSP00000341358; ENSG00000125991 [Q9Y282-1] ENST00000357394; ENSP00000349970; ENSG00000125991 [Q9Y282-3] |
GeneIDi | 51614 |
KEGGi | hsa:51614 |
UCSCi | uc002xcs.4, human [Q9Y282-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF308298 mRNA Translation: AAG48265.1 Different initiation. AF151812 mRNA Translation: AAD34049.1 AK074550 mRNA Translation: BAC11054.1 AF077030 mRNA Translation: AAD27763.1 AL121586 Genomic DNA Translation: CAB89412.1 AL121586 Genomic DNA Translation: CAI42842.1 BC009765 mRNA Translation: AAH09765.1 BC014014 mRNA Translation: AAH14014.1 AF116614 mRNA Translation: AAF71038.1 Different initiation. |
CCDSi | CCDS13257.1 [Q9Y282-1] CCDS13258.1 [Q9Y282-3] |
RefSeqi | NP_057050.1, NM_015966.2 [Q9Y282-1] NP_938408.1, NM_198398.1 [Q9Y282-3] |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
BioGRIDi | 119638, 278 interactors |
IntActi | Q9Y282, 257 interactors |
MINTi | Q9Y282 |
STRINGi | 9606.ENSP00000349970 |
PTM databases
GlyGeni | Q9Y282, 3 sites, 1 O-linked glycan (1 site) |
iPTMneti | Q9Y282 |
PhosphoSitePlusi | Q9Y282 |
SwissPalmi | Q9Y282 |
Genetic variation databases
BioMutai | ERGIC3 |
DMDMi | 37999823 |
Proteomic databases
EPDi | Q9Y282 |
jPOSTi | Q9Y282 |
MassIVEi | Q9Y282 |
PaxDbi | Q9Y282 |
PeptideAtlasi | Q9Y282 |
PRIDEi | Q9Y282 |
ProteomicsDBi | 85687 [Q9Y282-1] 85688 [Q9Y282-2] 85689 [Q9Y282-3] |
Protocols and materials databases
Antibodypediai | 3001, 240 antibodies |
DNASUi | 51614 |
Genome annotation databases
Ensembli | ENST00000348547; ENSP00000341358; ENSG00000125991 [Q9Y282-1] ENST00000357394; ENSP00000349970; ENSG00000125991 [Q9Y282-3] |
GeneIDi | 51614 |
KEGGi | hsa:51614 |
UCSCi | uc002xcs.4, human [Q9Y282-1] |
Organism-specific databases
CTDi | 51614 |
DisGeNETi | 51614 |
GeneCardsi | ERGIC3 |
HGNCi | HGNC:15927, ERGIC3 |
HPAi | ENSG00000125991, Low tissue specificity |
neXtProti | NX_Q9Y282 |
OpenTargetsi | ENSG00000125991 |
PharmGKBi | PA38050 |
VEuPathDBi | HostDB:ENSG00000125991.18 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG2667, Eukaryota |
GeneTreei | ENSGT00530000063113 |
InParanoidi | Q9Y282 |
OrthoDBi | 1318747at2759 |
PhylomeDBi | Q9Y282 |
TreeFami | TF300739 |
Enzyme and pathway databases
PathwayCommonsi | Q9Y282 |
SIGNORi | Q9Y282 |
Miscellaneous databases
BioGRID-ORCSi | 51614, 22 hits in 872 CRISPR screens |
ChiTaRSi | ERGIC3, human |
GeneWikii | ERGIC3 |
GenomeRNAii | 51614 |
Pharosi | Q9Y282, Tbio |
PROi | PR:Q9Y282 |
RNActi | Q9Y282, protein |
Gene expression databases
Bgeei | ENSG00000125991, Expressed in testis and 245 other tissues |
ExpressionAtlasi | Q9Y282, baseline and differential |
Genevisiblei | Q9Y282, HS |
Family and domain databases
InterProi | View protein in InterPro IPR012936, Erv_C IPR039542, Erv_N |
Pfami | View protein in Pfam PF07970, COPIIcoated_ERV, 1 hit PF13850, ERGIC_N, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | ERGI3_HUMAN | |
Accessioni | Q9Y282Primary (citable) accession number: Q9Y282 Secondary accession number(s): Q5JWS3 Q9P1L3 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | October 24, 2003 |
Last sequence update: | November 1, 1999 | |
Last modified: | February 10, 2021 | |
This is version 151 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human chromosome 20
Human chromosome 20: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - SIMILARITY comments
Index of protein domains and families