Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

UniProtKB - Q9Y282 (ERGI3_HUMAN)

Entry version 148 (12 Aug 2020)
Sequence version 1 (01 Nov 1999)
Previous versions | rss
Help videoAdd a publicationFeedback
Protein

Endoplasmic reticulum-Golgi intermediate compartment protein 3

Gene

ERGIC3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Possible role in transport between endoplasmic reticulum and Golgi.By similarity

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processER-Golgi transport, Transport

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		Q9Y282

SIGNOR Signaling Network Open Resource

More...SIGNORi		Q9Y282

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Endoplasmic reticulum-Golgi intermediate compartment protein 3
Alternative name(s):
Serologically defined breast cancer antigen NY-BR-84
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:ERGIC3
Synonyms:C20orf47, ERV46, SDBCAG84
ORF Names:CGI-54, PRO0989
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 20

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...EuPathDBi		HostDB:ENSG00000125991.18

Human Gene Nomenclature Database

More...HGNCi		HGNC:15927, ERGIC3

neXtProt; the human protein knowledge platform

More...neXtProti		NX_Q9Y282

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini1 – 25CytoplasmicSequence analysisAdd BLAST25
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei26 – 46HelicalSequence analysisAdd BLAST21
Topological domaini47 – 341LumenalSequence analysisAdd BLAST295
Transmembranei342 – 362HelicalSequence analysisAdd BLAST21
Topological domaini363 – 383CytoplasmicSequence analysisAdd BLAST21

Keywords - Cellular componenti

Endoplasmic reticulum, Golgi apparatus, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...DisGeNETi		51614

Open Targets

More...OpenTargetsi		ENSG00000125991

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA38050

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		Q9Y282, Tbio

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		ERGIC3

Domain mapping of disease mutations (DMDM)

More...DMDMi		37999823

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000976401 – 383Endoplasmic reticulum-Golgi intermediate compartment protein 3Add BLAST383

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei1N-acetylmethionineCombined sources1
Modified residuei116PhosphoserineCombined sources1
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi241N-linked (GlcNAc...) asparagine1 Publication1
Glycosylationi266N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Acetylation, Glycoprotein, Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		Q9Y282

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		Q9Y282

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		Q9Y282

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q9Y282

PeptideAtlas

More...PeptideAtlasi		Q9Y282

PRoteomics IDEntifications database

More...PRIDEi		Q9Y282

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		85687 [Q9Y282-1]
85688 [Q9Y282-2]
85689 [Q9Y282-3]

PTM databases

GlyGen: Computational and Informatics Resources for Glycoscience

More...GlyGeni		Q9Y282, 3 sites, 1 O-linked glycan (1 site)

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q9Y282

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q9Y282

SwissPalm database of S-palmitoylation events

More...SwissPalmi		Q9Y282

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000125991, Expressed in testis and 245 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		Q9Y282, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q9Y282, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000125991, Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with ERGIC1/ERGIC32.

1 Publication

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Q9Y282
With#Exp.IntAct
ABHD16A [O95870]3EBI-781551,EBI-348517
AGPAT4 [Q9NRZ5]3EBI-781551,EBI-1754287
AGTRAP - isoform 2 [Q6RW13-2]3EBI-781551,EBI-11522760
AIG1 - isoform 2 [Q9NVV5-2]3EBI-781551,EBI-11957045
ALG10 [Q5BKT4]3EBI-781551,EBI-13064220
AOC2 [O75106]3EBI-781551,EBI-17685278
APOC3 [P02656]3EBI-781551,EBI-1220113
APOD [P05090]3EBI-781551,EBI-715495
APOL2 [Q9BQE5]3EBI-781551,EBI-4290634
AQP10 [Q96PS8]3EBI-781551,EBI-12820279
AQP2 [P41181]3EBI-781551,EBI-12701138
AQP3 [Q92482]3EBI-781551,EBI-2808854
ASGR1 [P07306]3EBI-781551,EBI-1172335
ATP6V0C [P27449]3EBI-781551,EBI-721179
BCL2L1 [Q07817]3EBI-781551,EBI-78035
BCL2L2 [Q92843]3EBI-781551,EBI-707714
BET1 [O15155]3EBI-781551,EBI-749204
BIK [Q13323]3EBI-781551,EBI-700794
BNIP3 [Q12983]3EBI-781551,EBI-749464
BTN2A2 [Q8WVV5]3EBI-781551,EBI-8648738
C12orf10 [Q9HB07]3EBI-781551,EBI-709754
C16orf58 [Q96GQ5]3EBI-781551,EBI-8636004
C2 [P06681]3EBI-781551,EBI-2835920
C2CD2L [O14523]3EBI-781551,EBI-12822627
C4orf3 - isoform 2 [Q8WVX3-2]3EBI-781551,EBI-12003442
CCDC167 [Q9P0B6]3EBI-781551,EBI-9083477
CD207 [Q9UJ71]3EBI-781551,EBI-2873235
CD302 [Q8IX05]3EBI-781551,EBI-14259393
CD81 [P60033]3EBI-781551,EBI-712921
CDIPT [O14735]3EBI-781551,EBI-358858
CDS2 [O95674]3EBI-781551,EBI-3913685
CFHR5 [Q9BXR6]3EBI-781551,EBI-11579371
CIAO2A [Q9H5X1]3EBI-781551,EBI-752069
CLDN19 - isoform 2 [Q8N6F1-2]3EBI-781551,EBI-12256978
CLDN8 [P56748]3EBI-781551,EBI-10215641
CLDND2 [Q8NHS1]3EBI-781551,EBI-11959453
CMTM5 - isoform 2 [Q96DZ9-2]3EBI-781551,EBI-11522780
CNIH1 [O95406]3EBI-781551,EBI-12172273
CNIH3 [Q8TBE1]3EBI-781551,EBI-12208021
COL4A5 - isoform 2 [P29400-2]3EBI-781551,EBI-12211159
COX20 [Q5RI15]3EBI-781551,EBI-2834035
CTXN3 [Q4LDR2]3EBI-781551,EBI-12019274
CXorf66 [Q5JRM2]3EBI-781551,EBI-12823659
CYB561 [P49447]3EBI-781551,EBI-8646596
CYB561D2 [O14569]3EBI-781551,EBI-717654
CYBC1 [Q9BQA9]3EBI-781551,EBI-2680384
CYP4F2 [P78329]3EBI-781551,EBI-1752413
DEFB103B [P81534]3EBI-781551,EBI-12074168
EBP [Q15125]3EBI-781551,EBI-3915253
EHHADH [Q08426]3EBI-781551,EBI-2339219
EMC6 [Q9BV81]3EBI-781551,EBI-2820492
EMP1 [P54849]3EBI-781551,EBI-4319440
EMP3 [P54852]3EBI-781551,EBI-3907816
ENTPD3 - isoform 2 [O75355-2]3EBI-781551,EBI-12279764
EXTL1 [Q92935]3EBI-781551,EBI-1760167
FA2H [Q7L5A8]3EBI-781551,EBI-11337888
FAM3C [Q92520]3EBI-781551,EBI-2876774
FAXDC2 [Q96IV6]3EBI-781551,EBI-12142299
FETUB [Q9UGM5]3EBI-781551,EBI-13049494
FIS1 [Q9Y3D6]3EBI-781551,EBI-3385283
FKBP8 [Q14318]3EBI-781551,EBI-724839
FXYD2 - isoform 2 [P54710-2]3EBI-781551,EBI-13084584
FXYD3 - isoform 3 [Q14802-3]3EBI-781551,EBI-12175685
FXYD6 [Q9H0Q3]3EBI-781551,EBI-713304
GAST [P01350]3EBI-781551,EBI-3436637
GIMAP1 [Q8WWP7]3EBI-781551,EBI-11991950
GIMAP5 [Q96F15]3EBI-781551,EBI-6166686
GJB2 [P29033]3EBI-781551,EBI-3905204
GPM6B - isoform 3 [Q13491-3]3EBI-781551,EBI-11992640
GPR151 [Q8TDV0]3EBI-781551,EBI-11955647
GYPA [P02724]3EBI-781551,EBI-702665
HHATL [Q9HCP6]3EBI-781551,EBI-5916693
HMOX1 [P09601]3EBI-781551,EBI-2806151
HMOX2 [P30519]3EBI-781551,EBI-712096
IFITM3 [Q01628]3EBI-781551,EBI-7932862
IGFBP5 [P24593]3EBI-781551,EBI-720480
ITGAM [P11215]3EBI-781551,EBI-2568251
JAGN1 [Q8N5M9]3EBI-781551,EBI-10266796
KCNK1 [O00180]3EBI-781551,EBI-3914675
LHFPL5 [Q8TAF8]3EBI-781551,EBI-2820517
LPAR3 [Q9UBY5]3EBI-781551,EBI-12033434
LPCAT2 [Q7L5N7]3EBI-781551,EBI-4280011
MARCHF2 [Q9P0N8]3EBI-781551,EBI-10317612
MARCHF5 [Q9NX47]3EBI-781551,EBI-2341610
MFF - isoform 5 [Q9GZY8-5]3EBI-781551,EBI-11956541
MFSD6 [Q6ZSS7]3EBI-781551,EBI-2858252
MIP [P30301]3EBI-781551,EBI-8449636
MS4A13 [Q5J8X5]3EBI-781551,EBI-12070086
MYADM [Q96S97]3EBI-781551,EBI-13301517
NDRG4 - isoform 2 [Q9ULP0-2]3EBI-781551,EBI-11978907
NDUFB6 [O95139]3EBI-781551,EBI-1053340
NEU1 [Q99519]3EBI-781551,EBI-721517
NINJ2 [Q9NZG7]3EBI-781551,EBI-10317425
NKG7 [Q16617]3EBI-781551,EBI-3919611
NRAC [Q8N912]3EBI-781551,EBI-12051377
NRG4 [Q8WWG1]3EBI-781551,EBI-8637292
NRM [Q8IXM6]3EBI-781551,EBI-10262547
NSG1 [P42857]3EBI-781551,EBI-6380741
ORMDL1 [Q9P0S3]3EBI-781551,EBI-1054848
ORMDL3 [Q8N138]3EBI-781551,EBI-721750
PAQR5 [Q9NXK6]3EBI-781551,EBI-10316423
PAQR7 [Q86WK9]3EBI-781551,EBI-10694587
PEX11G [Q96HA9]3EBI-781551,EBI-17284886
PEX16 [Q9Y5Y5]3EBI-781551,EBI-981985
PGAP2 - isoform 5 [Q9UHJ9-5]3EBI-781551,EBI-12092917
PLLP [Q9Y342]3EBI-781551,EBI-3919291
PLP1 - isoform DM-20 [P60201-2]3EBI-781551,EBI-12188331
PLPP4 [Q5VZY2]3EBI-781551,EBI-10485931
PMP22 [Q01453]3EBI-781551,EBI-2845982
POMGNT1 [Q8WZA1]3EBI-781551,EBI-3912424
PPGB [Q59EV6]3EBI-781551,EBI-14210385
RFT1 [Q96AA3]3EBI-781551,EBI-6269616
RHAG [Q02094]3EBI-781551,EBI-14772355
RTP2 [Q5QGT7]3EBI-781551,EBI-10244780
SCARB2 [Q14108]3EBI-781551,EBI-1564650
SCD [O00767]3EBI-781551,EBI-2684237
SEC22B [O75396]3EBI-781551,EBI-1058865
SEC23A [Q15436]3EBI-781551,EBI-81088
SELENOK [Q9Y6D0]3EBI-781551,EBI-9679163
SERP2 [Q8N6R1]3EBI-781551,EBI-749270
SFXN5 [Q8TD22]3EBI-781551,EBI-17274136
SLC13A3 [Q8WWT9]3EBI-781551,EBI-12938720
SLC1A1 [P43005]3EBI-781551,EBI-745376
SLC30A8 [Q8IWU4]3EBI-781551,EBI-10262251
SLC35A1 [P78382]3EBI-781551,EBI-12870360
SLC35A4 [Q96G79]3EBI-781551,EBI-12363689
SLC35B2 [Q8TB61]3EBI-781551,EBI-1054782
SLC35B4 [Q969S0]3EBI-781551,EBI-10281213
SLC38A7 [Q9NVC3]3EBI-781551,EBI-10314552
SLC41A1 [Q8IVJ1]3EBI-781551,EBI-12266234
SLC41A2 [Q96JW4]3EBI-781551,EBI-10290130
SLC49A3 - isoform 2 [Q6UXD7-2]3EBI-781551,EBI-17682849
SMAGP [Q0VAQ4]3EBI-781551,EBI-10226799
SMCO4 [Q9NRQ5]3EBI-781551,EBI-8640191
SMIM1 [B2RUZ4]3EBI-781551,EBI-12188413
SMIM3 [Q9BZL3]3EBI-781551,EBI-741850
SNORC [Q6UX34]3EBI-781551,EBI-11957067
SPN [P16150]3EBI-781551,EBI-10049055
STATH [P02808]3EBI-781551,EBI-738687
STX12 [Q86Y82]3EBI-781551,EBI-2691717
STX1B [P61266]3EBI-781551,EBI-9071709
STX3 [Q13277]3EBI-781551,EBI-1394295
STX8 [Q9UNK0]3EBI-781551,EBI-727240
SYNGR1 - isoform 1B [O43759-2]3EBI-781551,EBI-12187159
SYNJ2BP [P57105]3EBI-781551,EBI-1049004
SYS1 [Q8N2H4]3EBI-781551,EBI-13075176
TAP1 [Q03518]3EBI-781551,EBI-747259
TECR [Q9NZ01]3EBI-781551,EBI-2877718
TF [P02787]3EBI-781551,EBI-714319
THBD [P07204]3EBI-781551,EBI-941422
TM4SF4 [P48230]3EBI-781551,EBI-8650934
TMEM100 [Q9NV29]3EBI-781551,EBI-8644968
TMEM107 [Q6UX40]3EBI-781551,EBI-12845616
TMEM109 [Q9BVC6]3EBI-781551,EBI-1057733
TMEM120B [A0PK00]3EBI-781551,EBI-10171534
TMEM128 - isoform 2 [Q5BJH2-2]3EBI-781551,EBI-10694905
TMEM141 [Q96I45]3EBI-781551,EBI-17681263
TMEM14A [Q9Y6G1]3EBI-781551,EBI-2800360
TMEM14B [Q9NUH8]3EBI-781551,EBI-8638294
TMEM179B [Q7Z7N9]3EBI-781551,EBI-11724423
TMEM203 [Q969S6]3EBI-781551,EBI-12274070
TMEM218 [A2RU14]3EBI-781551,EBI-10173151
TMEM222 [Q9H0R3]3EBI-781551,EBI-347385
TMEM229B [Q8NBD8]3EBI-781551,EBI-12195227
TMEM243 [Q9BU79]3EBI-781551,EBI-12887458
TMEM42 [Q69YG0]3EBI-781551,EBI-12038591
TMEM60 [Q9H2L4]3EBI-781551,EBI-2852148
TMEM65 [Q6PI78]3EBI-781551,EBI-6656213
TMEM86A [Q8N2M4]3EBI-781551,EBI-12015604
TMEM86B [Q8N661]3EBI-781551,EBI-2548832
TMEM97 [Q5BJF2]3EBI-781551,EBI-12111910
TMUB2 [Q71RG4]3EBI-781551,EBI-2820477
TNFRSF10C [O14798]3EBI-781551,EBI-717441
TOMM6 [Q96B49]3EBI-781551,EBI-10826510
TRAM1L1 [Q8N609]3EBI-781551,EBI-11996766
TRIM32 [Q13049]3EBI-781551,EBI-742790
TSPAN33 [Q86UF1]3EBI-781551,EBI-12045841
TSPO2 [Q5TGU0]3EBI-781551,EBI-12195249
TTMP [Q5BVD1]3EBI-781551,EBI-10243654
TUSC5 [A5PKU2]3EBI-781551,EBI-11988865
UBE2J1 [Q9Y385]3EBI-781551,EBI-988826
UBIAD1 [Q9Y5Z9]3EBI-781551,EBI-2819725
UNC50 [Q53HI1]3EBI-781551,EBI-7601760
UNC93B1 [Q9H1C4]3EBI-781551,EBI-4401271
VAMP1 - isoform 2 [P23763-3]3EBI-781551,EBI-12097582
VAMP2 [P63027]3EBI-781551,EBI-520113
VAMP3 [Q15836]3EBI-781551,EBI-722343
VAMP4 [O75379]3EBI-781551,EBI-744953
VAMP5 [O95183]3EBI-781551,EBI-10191195
VKORC1 [Q9BQB6]3EBI-781551,EBI-6256462
VKORC1L1 [Q8N0U8]3EBI-781551,EBI-11337915
VMP1 [Q96GC9]3EBI-781551,EBI-2800296
VSTM1 - isoform 3 [Q6UX27-3]3EBI-781551,EBI-12190699
VTI1B [Q9UEU0]3EBI-781551,EBI-723716
YIF1A [O95070]3EBI-781551,EBI-2799703
YIPF1 [Q9Y548]3EBI-781551,EBI-7850136
YIPF2 [Q9BWQ6]3EBI-781551,EBI-751204
YIPF4 [Q9BSR8]3EBI-781551,EBI-751253
YIPF6 [Q96EC8]3EBI-781551,EBI-751210
ZDHHC15 [Q96MV8]3EBI-781551,EBI-12837904
ZDHHC21 [Q8IVQ6]3EBI-781551,EBI-2849773
ZFPL1 [O95159]3EBI-781551,EBI-718439
Q96FB23EBI-781551,EBI-2857623

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		119638, 80 interactors

Protein interaction database and analysis system

More...IntActi		Q9Y282, 257 interactors

Molecular INTeraction database

More...MINTi		Q9Y282

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000349970

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		Q9Y282, protein

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the ERGIC family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG2667, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00530000063113

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q9Y282

KEGG Orthology (KO)

More...KOi		K20367

Database of Orthologous Groups

More...OrthoDBi		1318747at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q9Y282

TreeFam database of animal gene trees

More...TreeFami		TF300739

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR012936, Erv_C
IPR039542, Erv_N

Pfam protein domain database

More...Pfami		View protein in Pfam
PF07970, COPIIcoated_ERV, 1 hit
PF13850, ERGIC_N, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 3 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 7 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q9Y282-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MEALGKLKQF DAYPKTLEDF RVKTCGGATV TIVSGLLMLL LFLSELQYYL 
        60         70         80         90        100
TTEVHPELYV DKSRGDKLKI NIDVLFPHMP CAYLSIDAMD VAGEQQLDVE 
       110        120        130        140        150
HNLFKQRLDK DGIPVSSEAE RHELGKVEVT VFDPDSLDPD RCESCYGAEA 
       160        170        180        190        200
EDIKCCNTCE DVREAYRRRG WAFKNPDTIE QCRREGFSQK MQEQKNEGCQ 
       210        220        230        240        250
VYGFLEVNKV AGNFHFAPGK SFQQSHVHVH DLQSFGLDNI NMTHYIQHLS 
       260        270        280        290        300
FGEDYPGIVN PLDHTNVTAP QASMMFQYFV KVVPTVYMKV DGEVLRTNQF 
       310        320        330        340        350
SVTRHEKVAN GLLGDQGLPG VFVLYELSPM MVKLTEKHRS FTHFLTGVCA 
       360        370        380 
IIGGMFTVAG LIDSLIYHSA RAIQKKIDLG KTT
Length:383
Mass (Da):43,222
Last modified:November 1, 1999 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i8370FB3067AD95CE
GO
Isoform 2 (identifier: Q9Y282-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     229-230: VH → GE
     231-383: Missing.

Show »
Length:230
Mass (Da):26,155
Checksum:i11727EE72A9A2587
GO
Isoform 3 (identifier: Q9Y282-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     229-229: V → VHAVEI

Show »
Length:388
Mass (Da):43,772
Checksum:i54AE001D4A66DAF4
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 7 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H0Y5K5H0Y5K5_HUMAN
Endoplasmic reticulum-Golgi interme...
ERGIC3
397Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0Y621H0Y621_HUMAN
Endoplasmic reticulum-Golgi interme...
ERGIC3
326Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0Y6Z0H0Y6Z0_HUMAN
Endoplasmic reticulum-Golgi interme...
ERGIC3
157Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0Y802H0Y802_HUMAN
Endoplasmic reticulum-Golgi interme...
ERGIC3
130Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0C4DH46A0A0C4DH46_HUMAN
Endoplasmic reticulum-Golgi interme...
ERGIC3
123Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A6PVJ2A6PVJ2_HUMAN
ERGIC and golgi 3
ERGIC3 RP3-477O4.12-011
118Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A1W2PPS8A0A1W2PPS8_HUMAN
Endoplasmic reticulum-Golgi interme...
ERGIC3
198Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAF71038 differs from that shown. Reason: Erroneous initiation.Curated
The sequence AAG48265 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti239N → D in BAC11054 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_048939113I → L. Corresponds to variant dbSNP:rs35505616Ensembl.1
Natural variantiVAR_036553297T → K in a colorectal cancer sample; somatic mutation. 1 Publication1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_008652229 – 230VH → GE in isoform 2. 1 Publication2
Alternative sequenceiVSP_019208229V → VHAVEI in isoform 3. 1 Publication1
Alternative sequenceiVSP_008653231 – 383Missing in isoform 2. 1 PublicationAdd BLAST153

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AF308298 mRNA Translation: AAG48265.1 Different initiation.
AF151812 mRNA Translation: AAD34049.1
AK074550 mRNA Translation: BAC11054.1
AF077030 mRNA Translation: AAD27763.1
AL121586 Genomic DNA Translation: CAB89412.1
AL121586 Genomic DNA Translation: CAI42842.1
BC009765 mRNA Translation: AAH09765.1
BC014014 mRNA Translation: AAH14014.1
AF116614 mRNA Translation: AAF71038.1 Different initiation.

The Consensus CDS (CCDS) project

More...CCDSi		CCDS13257.1 [Q9Y282-1]
CCDS13258.1 [Q9Y282-3]

NCBI Reference Sequences

More...RefSeqi		NP_057050.1, NM_015966.2 [Q9Y282-1]
NP_938408.1, NM_198398.1 [Q9Y282-3]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000348547; ENSP00000341358; ENSG00000125991 [Q9Y282-1]
ENST00000357394; ENSP00000349970; ENSG00000125991 [Q9Y282-3]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		51614

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:51614

UCSC genome browser

More...UCSCi		uc002xcs.4, human [Q9Y282-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF308298 mRNA Translation: AAG48265.1 Different initiation.
AF151812 mRNA Translation: AAD34049.1
AK074550 mRNA Translation: BAC11054.1
AF077030 mRNA Translation: AAD27763.1
AL121586 Genomic DNA Translation: CAB89412.1
AL121586 Genomic DNA Translation: CAI42842.1
BC009765 mRNA Translation: AAH09765.1
BC014014 mRNA Translation: AAH14014.1
AF116614 mRNA Translation: AAF71038.1 Different initiation.
CCDSiCCDS13257.1 [Q9Y282-1]
CCDS13258.1 [Q9Y282-3]
RefSeqiNP_057050.1, NM_015966.2 [Q9Y282-1]
NP_938408.1, NM_198398.1 [Q9Y282-3]

3D structure databases

Database of comparative protein structure models

More...ModBasei		Search...

SWISS-MODEL Interactive Workspace

More...SWISS-MODEL-Workspacei		Submit a new modelling project...

Protein-protein interaction databases

BioGRIDi119638, 80 interactors
IntActiQ9Y282, 257 interactors
MINTiQ9Y282
STRINGi9606.ENSP00000349970

PTM databases

GlyGeniQ9Y282, 3 sites, 1 O-linked glycan (1 site)
iPTMnetiQ9Y282
PhosphoSitePlusiQ9Y282
SwissPalmiQ9Y282

Polymorphism and mutation databases

BioMutaiERGIC3
DMDMi37999823

Proteomic databases

EPDiQ9Y282
jPOSTiQ9Y282
MassIVEiQ9Y282
PaxDbiQ9Y282
PeptideAtlasiQ9Y282
PRIDEiQ9Y282
ProteomicsDBi85687 [Q9Y282-1]
85688 [Q9Y282-2]
85689 [Q9Y282-3]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		3001, 240 antibodies

The DNASU plasmid repository

More...DNASUi		51614

Genome annotation databases

EnsembliENST00000348547; ENSP00000341358; ENSG00000125991 [Q9Y282-1]
ENST00000357394; ENSP00000349970; ENSG00000125991 [Q9Y282-3]
GeneIDi51614
KEGGihsa:51614
UCSCiuc002xcs.4, human [Q9Y282-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		51614
DisGeNETi51614
EuPathDBiHostDB:ENSG00000125991.18

GeneCards: human genes, protein and diseases

More...GeneCardsi		ERGIC3
HGNCiHGNC:15927, ERGIC3
HPAiENSG00000125991, Low tissue specificity
neXtProtiNX_Q9Y282
OpenTargetsiENSG00000125991
PharmGKBiPA38050

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG2667, Eukaryota
GeneTreeiENSGT00530000063113
InParanoidiQ9Y282
KOiK20367
OrthoDBi1318747at2759
PhylomeDBiQ9Y282
TreeFamiTF300739

Enzyme and pathway databases

PathwayCommonsiQ9Y282
SIGNORiQ9Y282

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		51614, 21 hits in 869 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		ERGIC3, human

The Gene Wiki collection of pages on human genes and proteins

More...GeneWikii		ERGIC3

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		51614
PharosiQ9Y282, Tbio

Protein Ontology

More...PROi		PR:Q9Y282
RNActiQ9Y282, protein

Gene expression databases

BgeeiENSG00000125991, Expressed in testis and 245 other tissues
ExpressionAtlasiQ9Y282, baseline and differential
GenevisibleiQ9Y282, HS

Family and domain databases

InterProiView protein in InterPro
IPR012936, Erv_C
IPR039542, Erv_N
PfamiView protein in Pfam
PF07970, COPIIcoated_ERV, 1 hit
PF13850, ERGIC_N, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiERGI3_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9Y282
Secondary accession number(s): Q5JWS3
, Q6ZWP7, Q9H276, Q9P1L3
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 24, 2003
Last sequence update: November 1, 1999
Last modified: August 12, 2020
This is version 148 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human chromosome 20
    Human chromosome 20: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again