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Protein

Endoplasmic reticulum-Golgi intermediate compartment protein 3

Gene

ERGIC3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Possible role in transport between endoplasmic reticulum and Golgi.By similarity

GO - Biological processi

Keywordsi

Biological processER-Golgi transport, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Endoplasmic reticulum-Golgi intermediate compartment protein 3
Alternative name(s):
Serologically defined breast cancer antigen NY-BR-84
Gene namesi
Name:ERGIC3
Synonyms:C20orf47, ERV46, SDBCAG84
ORF Names:CGI-54, PRO0989
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 20

Organism-specific databases

EuPathDBiHostDB:ENSG00000125991.18
HGNCiHGNC:15927 ERGIC3
neXtProtiNX_Q9Y282

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 25CytoplasmicSequence analysisAdd BLAST25
Transmembranei26 – 46HelicalSequence analysisAdd BLAST21
Topological domaini47 – 341LumenalSequence analysisAdd BLAST295
Transmembranei342 – 362HelicalSequence analysisAdd BLAST21
Topological domaini363 – 383CytoplasmicSequence analysisAdd BLAST21

Keywords - Cellular componenti

Endoplasmic reticulum, Golgi apparatus, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi51614
OpenTargetsiENSG00000125991
PharmGKBiPA38050

Polymorphism and mutation databases

BioMutaiERGIC3
DMDMi37999823

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000976401 – 383Endoplasmic reticulum-Golgi intermediate compartment protein 3Add BLAST383

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1N-acetylmethionineCombined sources1
Modified residuei116PhosphoserineCombined sources1
Glycosylationi241N-linked (GlcNAc...) asparagine1 Publication1
Glycosylationi266N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Acetylation, Glycoprotein, Phosphoprotein

Proteomic databases

EPDiQ9Y282
PaxDbiQ9Y282
PeptideAtlasiQ9Y282
PRIDEiQ9Y282
ProteomicsDBi85687
85688 [Q9Y282-2]
85689 [Q9Y282-3]

PTM databases

iPTMnetiQ9Y282
PhosphoSitePlusiQ9Y282
SwissPalmiQ9Y282

Expressioni

Gene expression databases

BgeeiENSG00000125991 Expressed in 233 organ(s), highest expression level in testis
CleanExiHS_ERGIC3
ExpressionAtlasiQ9Y282 baseline and differential
GenevisibleiQ9Y282 HS

Organism-specific databases

HPAiHPA015242
HPA015968

Interactioni

Subunit structurei

Interacts with ERGIC1/ERGIC32.1 Publication

Protein-protein interaction databases

BioGridi119638, 70 interactors
IntActiQ9Y282, 199 interactors
MINTiQ9Y282
STRINGi9606.ENSP00000349970

Structurei

3D structure databases

ProteinModelPortaliQ9Y282
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the ERGIC family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG2667 Eukaryota
ENOG410XP7X LUCA
GeneTreeiENSGT00530000063113
HOGENOMiHOG000210954
HOVERGENiHBG105706
InParanoidiQ9Y282
KOiK20367
PhylomeDBiQ9Y282
TreeFamiTF300739

Family and domain databases

InterProiView protein in InterPro
IPR012936 Erv_C
IPR039542 Erv_N
PfamiView protein in Pfam
PF07970 COPIIcoated_ERV, 1 hit
PF13850 ERGIC_N, 1 hit

Sequences (3+)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 7 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q9Y282-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MEALGKLKQF DAYPKTLEDF RVKTCGGATV TIVSGLLMLL LFLSELQYYL
60 70 80 90 100
TTEVHPELYV DKSRGDKLKI NIDVLFPHMP CAYLSIDAMD VAGEQQLDVE
110 120 130 140 150
HNLFKQRLDK DGIPVSSEAE RHELGKVEVT VFDPDSLDPD RCESCYGAEA
160 170 180 190 200
EDIKCCNTCE DVREAYRRRG WAFKNPDTIE QCRREGFSQK MQEQKNEGCQ
210 220 230 240 250
VYGFLEVNKV AGNFHFAPGK SFQQSHVHVH DLQSFGLDNI NMTHYIQHLS
260 270 280 290 300
FGEDYPGIVN PLDHTNVTAP QASMMFQYFV KVVPTVYMKV DGEVLRTNQF
310 320 330 340 350
SVTRHEKVAN GLLGDQGLPG VFVLYELSPM MVKLTEKHRS FTHFLTGVCA
360 370 380
IIGGMFTVAG LIDSLIYHSA RAIQKKIDLG KTT
Length:383
Mass (Da):43,222
Last modified:November 1, 1999 - v1
Checksum:i8370FB3067AD95CE
GO
Isoform 2 (identifier: Q9Y282-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     229-230: VH → GE
     231-383: Missing.

Note: No experimental confirmation available.
Show »
Length:230
Mass (Da):26,155
Checksum:i11727EE72A9A2587
GO
Isoform 3 (identifier: Q9Y282-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     229-229: V → VHAVEI

Show »
Length:388
Mass (Da):43,772
Checksum:i54AE001D4A66DAF4
GO

Computationally mapped potential isoform sequencesi

There are 7 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H0Y5K5H0Y5K5_HUMAN
Endoplasmic reticulum-Golgi interme...
ERGIC3
397Annotation score:
A6PVJ2A6PVJ2_HUMAN
ERGIC and golgi 3
ERGIC3 RP3-477O4.12-011
118Annotation score:
H0Y621H0Y621_HUMAN
Endoplasmic reticulum-Golgi interme...
ERGIC3
326Annotation score:
H0Y802H0Y802_HUMAN
Endoplasmic reticulum-Golgi interme...
ERGIC3
130Annotation score:
H0Y6Z0H0Y6Z0_HUMAN
Endoplasmic reticulum-Golgi interme...
ERGIC3
157Annotation score:
A0A0C4DH46A0A0C4DH46_HUMAN
Endoplasmic reticulum-Golgi interme...
ERGIC3
123Annotation score:
A0A1W2PPS8A0A1W2PPS8_HUMAN
Endoplasmic reticulum-Golgi interme...
ERGIC3
198Annotation score:

Sequence cautioni

The sequence AAF71038 differs from that shown. Reason: Erroneous initiation.Curated
The sequence AAG48265 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti239N → D in BAC11054 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_048939113I → L. Corresponds to variant dbSNP:rs35505616Ensembl.1
Natural variantiVAR_036553297T → K in a colorectal cancer sample; somatic mutation. 1 Publication1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_008652229 – 230VH → GE in isoform 2. 1 Publication2
Alternative sequenceiVSP_019208229V → VHAVEI in isoform 3. 1 Publication1
Alternative sequenceiVSP_008653231 – 383Missing in isoform 2. 1 PublicationAdd BLAST153

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF308298 mRNA Translation: AAG48265.1 Different initiation.
AF151812 mRNA Translation: AAD34049.1
AK074550 mRNA Translation: BAC11054.1
AF077030 mRNA Translation: AAD27763.1
AL121586 Genomic DNA Translation: CAB89412.1
AL121586 Genomic DNA Translation: CAI42842.1
BC009765 mRNA Translation: AAH09765.1
BC014014 mRNA Translation: AAH14014.1
AF116614 mRNA Translation: AAF71038.1 Different initiation.
CCDSiCCDS13257.1 [Q9Y282-1]
CCDS13258.1 [Q9Y282-3]
RefSeqiNP_057050.1, NM_015966.2 [Q9Y282-1]
NP_938408.1, NM_198398.1 [Q9Y282-3]
UniGeneiHs.472558

Genome annotation databases

EnsembliENST00000348547; ENSP00000341358; ENSG00000125991 [Q9Y282-1]
ENST00000357394; ENSP00000349970; ENSG00000125991 [Q9Y282-3]
GeneIDi51614
KEGGihsa:51614
UCSCiuc002xcs.4 human [Q9Y282-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF308298 mRNA Translation: AAG48265.1 Different initiation.
AF151812 mRNA Translation: AAD34049.1
AK074550 mRNA Translation: BAC11054.1
AF077030 mRNA Translation: AAD27763.1
AL121586 Genomic DNA Translation: CAB89412.1
AL121586 Genomic DNA Translation: CAI42842.1
BC009765 mRNA Translation: AAH09765.1
BC014014 mRNA Translation: AAH14014.1
AF116614 mRNA Translation: AAF71038.1 Different initiation.
CCDSiCCDS13257.1 [Q9Y282-1]
CCDS13258.1 [Q9Y282-3]
RefSeqiNP_057050.1, NM_015966.2 [Q9Y282-1]
NP_938408.1, NM_198398.1 [Q9Y282-3]
UniGeneiHs.472558

3D structure databases

ProteinModelPortaliQ9Y282
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi119638, 70 interactors
IntActiQ9Y282, 199 interactors
MINTiQ9Y282
STRINGi9606.ENSP00000349970

PTM databases

iPTMnetiQ9Y282
PhosphoSitePlusiQ9Y282
SwissPalmiQ9Y282

Polymorphism and mutation databases

BioMutaiERGIC3
DMDMi37999823

Proteomic databases

EPDiQ9Y282
PaxDbiQ9Y282
PeptideAtlasiQ9Y282
PRIDEiQ9Y282
ProteomicsDBi85687
85688 [Q9Y282-2]
85689 [Q9Y282-3]

Protocols and materials databases

DNASUi51614
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000348547; ENSP00000341358; ENSG00000125991 [Q9Y282-1]
ENST00000357394; ENSP00000349970; ENSG00000125991 [Q9Y282-3]
GeneIDi51614
KEGGihsa:51614
UCSCiuc002xcs.4 human [Q9Y282-1]

Organism-specific databases

CTDi51614
DisGeNETi51614
EuPathDBiHostDB:ENSG00000125991.18
GeneCardsiERGIC3
HGNCiHGNC:15927 ERGIC3
HPAiHPA015242
HPA015968
neXtProtiNX_Q9Y282
OpenTargetsiENSG00000125991
PharmGKBiPA38050
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG2667 Eukaryota
ENOG410XP7X LUCA
GeneTreeiENSGT00530000063113
HOGENOMiHOG000210954
HOVERGENiHBG105706
InParanoidiQ9Y282
KOiK20367
PhylomeDBiQ9Y282
TreeFamiTF300739

Miscellaneous databases

ChiTaRSiERGIC3 human
GeneWikiiERGIC3
GenomeRNAii51614
PROiPR:Q9Y282

Gene expression databases

BgeeiENSG00000125991 Expressed in 233 organ(s), highest expression level in testis
CleanExiHS_ERGIC3
ExpressionAtlasiQ9Y282 baseline and differential
GenevisibleiQ9Y282 HS

Family and domain databases

InterProiView protein in InterPro
IPR012936 Erv_C
IPR039542 Erv_N
PfamiView protein in Pfam
PF07970 COPIIcoated_ERV, 1 hit
PF13850 ERGIC_N, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiERGI3_HUMAN
AccessioniPrimary (citable) accession number: Q9Y282
Secondary accession number(s): Q5JWS3
, Q6ZWP7, Q9H276, Q9P1L3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 24, 2003
Last sequence update: November 1, 1999
Last modified: October 10, 2018
This is version 135 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  2. SIMILARITY comments
    Index of protein domains and families
  3. Human chromosome 20
    Human chromosome 20: entries, gene names and cross-references to MIM
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
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