UniProtKB - Q9Y282 (ERGI3_HUMAN)

BLAST

>sp|Q9Y282|ERGI3_HUMAN Endoplasmic reticulum-Golgi intermediate compartment protein 3 OS=Homo sapiens OX=9606 GN=ERGIC3 PE=1 SV=1
MEALGKLKQFDAYPKTLEDFRVKTCGGATVTIVSGLLMLLLFLSELQYYLTTEVHPELYV
DKSRGDKLKINIDVLFPHMPCAYLSIDAMDVAGEQQLDVEHNLFKQRLDKDGIPVSSEAE
RHELGKVEVTVFDPDSLDPDRCESCYGAEAEDIKCCNTCEDVREAYRRRGWAFKNPDTIE
QCRREGFSQKMQEQKNEGCQVYGFLEVNKVAGNFHFAPGKSFQQSHVHVHDLQSFGLDNI
NMTHYIQHLSFGEDYPGIVNPLDHTNVTAPQASMMFQYFVKVVPTVYMKVDGEVLRTNQF
SVTRHEKVANGLLGDQGLPGVFVLYELSPMMVKLTEKHRSFTHFLTGVCAIIGGMFTVAG
LIDSLIYHSARAIQKKIDLGKTT

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History
Entry version 134 (12 Sep 2018)
Sequence version 1 (01 Nov 1999)
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Protein

Endoplasmic reticulum-Golgi intermediate compartment protein 3

Gene

ERGIC3

Organism

Homo sapiens (Human)

Status

Reviewed-Annotation score: -Experimental evidence at protein levelⁱ

Functionⁱ

Possible role in transport between endoplasmic reticulum and Golgi.By similarity

GO - Biological processⁱ

vesicle-mediated transport Source: UniProtKB-KW

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Biological process	ER-Golgi transport, Transport

Biological process

ER-Golgi transport, Transport

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Endoplasmic reticulum-Golgi intermediate compartment protein 3 Alternative name(s): Serologically defined breast cancer antigen NY-BR-84
Gene namesⁱ	Name:ERGIC3 Synonyms:C20orf47, ERV46, SDBCAG84 ORF Names:CGI-54, PRO0989
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 20

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000125991.18
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:15927 ERGIC3
neXtProtⁱ	NX_Q9Y282

Topology

Feature key	Position(s)	DescriptionActions	Length
Topological domainⁱ	1 – 25	CytoplasmicSequence analysisAdd BLAST	25
Transmembraneⁱ	26 – 46	HelicalSequence analysisAdd BLAST	21
Topological domainⁱ	47 – 341	LumenalSequence analysisAdd BLAST	295
Transmembraneⁱ	342 – 362	HelicalSequence analysisAdd BLAST	21
Topological domainⁱ	363 – 383	CytoplasmicSequence analysisAdd BLAST	21

Keywords - Cellular componentⁱ

Endoplasmic reticulum, Golgi apparatus, Membrane

Pathology & Biotechⁱ

Organism-specific databases

DisGeNET More...DisGeNETⁱ	51614
Open Targets More...OpenTargetsⁱ	ENSG00000125991
PharmGKBⁱ	PA38050

Polymorphism and mutation databases

BioMutaⁱ	ERGIC3
DMDMⁱ	37999823

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000097640	1 – 383	Endoplasmic reticulum-Golgi intermediate compartment protein 3Add BLAST		383

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Modified residueⁱ	1	N-acetylmethionineCombined sources	1
Modified residueⁱ	116	PhosphoserineCombined sources	1
Glycosylationⁱ	241	N-linked (GlcNAc...) asparagine1 Publication	1
Glycosylationⁱ	266	N-linked (GlcNAc...) asparagineSequence analysis	1

Keywords - PTMⁱ

Acetylation, Glycoprotein, Phosphoprotein

Proteomic databases

EPDⁱ	Q9Y282
PaxDbⁱ	Q9Y282
PeptideAtlas More...PeptideAtlasⁱ	Q9Y282
PRIDEⁱ	Q9Y282
ProteomicsDBⁱ	85687 85688 [Q9Y282-2] 85689 [Q9Y282-3]

PTM databases

iPTMnetⁱ	Q9Y282
PhosphoSitePlusⁱ	Q9Y282
SwissPalmⁱ	Q9Y282

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSG00000125991 Expressed in 233 organ(s), highest expression level in testis
CleanExⁱ	HS_ERGIC3
ExpressionAtlasⁱ	Q9Y282 baseline and differential
Genevisibleⁱ	Q9Y282 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA015242 HPA015968

HPAⁱ

HPA015242
HPA015968

Interactionⁱ

Subunit structureⁱ

Interacts with ERGIC1/ERGIC32.1 Publication

Protein-protein interaction databases

BioGridⁱ	119638, 70 interactors
IntActⁱ	Q9Y282, 199 interactors
Molecular INTeraction database More...MINTⁱ	Q9Y282
STRINGⁱ	9606.ENSP00000349970

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q9Y282
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Sequence similaritiesⁱ

Belongs to the ERGIC family.Curated

Keywords - Domainⁱ

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGⁱ	KOG2667 Eukaryota ENOG410XP7X LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00530000063113
HOGENOMⁱ	HOG000210954
HOVERGENⁱ	HBG105706
InParanoidⁱ	Q9Y282
KEGG Orthology (KO) More...KOⁱ	K20367
PhylomeDBⁱ	Q9Y282
TreeFamⁱ	TF300739

Family and domain databases

InterProⁱ	View protein in InterPro IPR012936 Erv_C
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF07970 COPIIcoated_ERV, 1 hit

Sequences (3+)ⁱ

Sequence statusⁱ: Complete.

This entry describes 3 isoformsⁱ produced by alternative splicing. Align Add to basket

This entry has 3 described isoforms and 7 potential isoforms that are computationally mapped.ⁱShow all

Isoform 1 (identifier: Q9Y282-1) [UniParc]FASTA Add to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MEALGKLKQF DAYPKTLEDF RVKTCGGATV TIVSGLLMLL LFLSELQYYL 
        60         70         80         90        100
TTEVHPELYV DKSRGDKLKI NIDVLFPHMP CAYLSIDAMD VAGEQQLDVE 
       110        120        130        140        150
HNLFKQRLDK DGIPVSSEAE RHELGKVEVT VFDPDSLDPD RCESCYGAEA 
       160        170        180        190        200
EDIKCCNTCE DVREAYRRRG WAFKNPDTIE QCRREGFSQK MQEQKNEGCQ 
       210        220        230        240        250
VYGFLEVNKV AGNFHFAPGK SFQQSHVHVH DLQSFGLDNI NMTHYIQHLS 
       260        270        280        290        300
FGEDYPGIVN PLDHTNVTAP QASMMFQYFV KVVPTVYMKV DGEVLRTNQF 
       310        320        330        340        350
SVTRHEKVAN GLLGDQGLPG VFVLYELSPM MVKLTEKHRS FTHFLTGVCA 
       360        370        380 
IIGGMFTVAG LIDSLIYHSA RAIQKKIDLG KTT

Length:383

Mass (Da):43,222

Last modified:November 1, 1999 - v1

Checksum:ⁱ8370FB3067AD95CE

Isoform 2 (identifier: Q9Y282-2) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
229-230: VH → GE
231-383: Missing.

« Hide

        10         20         30         40         50
MEALGKLKQF DAYPKTLEDF RVKTCGGATV TIVSGLLMLL LFLSELQYYL 
        60         70         80         90        100
TTEVHPELYV DKSRGDKLKI NIDVLFPHMP CAYLSIDAMD VAGEQQLDVE 
       110        120        130        140        150
HNLFKQRLDK DGIPVSSEAE RHELGKVEVT VFDPDSLDPD RCESCYGAEA 
       160        170        180        190        200
EDIKCCNTCE DVREAYRRRG WAFKNPDTIE QCRREGFSQK MQEQKNEGCQ 
       210        220        230
VYGFLEVNKV AGNFHFAPGK SFQQSHVHGE

Note: No experimental confirmation available.

Show »

Length:230

Mass (Da):26,155

Checksum:ⁱ11727EE72A9A2587

Isoform 3 (identifier: Q9Y282-3) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
229-229: V → VHAVEI

« Hide

        10         20         30         40         50
MEALGKLKQF DAYPKTLEDF RVKTCGGATV TIVSGLLMLL LFLSELQYYL 
        60         70         80         90        100
TTEVHPELYV DKSRGDKLKI NIDVLFPHMP CAYLSIDAMD VAGEQQLDVE 
       110        120        130        140        150
HNLFKQRLDK DGIPVSSEAE RHELGKVEVT VFDPDSLDPD RCESCYGAEA 
       160        170        180        190        200
EDIKCCNTCE DVREAYRRRG WAFKNPDTIE QCRREGFSQK MQEQKNEGCQ 
       210        220        230        240        250
VYGFLEVNKV AGNFHFAPGK SFQQSHVHVH AVEIHDLQSF GLDNINMTHY 
       260        270        280        290        300
IQHLSFGEDY PGIVNPLDHT NVTAPQASMM FQYFVKVVPT VYMKVDGEVL 
       310        320        330        340        350
RTNQFSVTRH EKVANGLLGD QGLPGVFVLY ELSPMMVKLT EKHRSFTHFL 
       360        370        380 
TGVCAIIGGM FTVAGLIDSL IYHSARAIQK KIDLGKTT

Show »

Length:388

Mass (Da):43,772

Checksum:ⁱ54AE001D4A66DAF4

Computationally mapped potential isoform sequencesⁱ

There are 7 potential isoforms mapped to this entry.BLAST Align Show all Add to basket

Entry	Entry name	Protein names	Gene names	Length	Annotation
H0Y5K5	H0Y5K5_HUMAN	Endoplasmic reticulum-Golgi interme... Endoplasmic reticulum-Golgi intermediate compartment protein 3	ERGIC3	397	Annotation score:
H0Y802	H0Y802_HUMAN	Endoplasmic reticulum-Golgi interme... Endoplasmic reticulum-Golgi intermediate compartment protein 3	ERGIC3	130	Annotation score:
H0Y621	H0Y621_HUMAN	Endoplasmic reticulum-Golgi interme... Endoplasmic reticulum-Golgi intermediate compartment protein 3	ERGIC3	326	Annotation score:
A6PVJ2	A6PVJ2_HUMAN	ERGIC and golgi 3 ERGIC and golgi 3 (Endoplasmic reticulum-Golgi intermediate compartment protein 3)	ERGIC3 RP3-477O4.12-011	118	Annotation score:
H0Y6Z0	H0Y6Z0_HUMAN	Endoplasmic reticulum-Golgi interme... Endoplasmic reticulum-Golgi intermediate compartment protein 3	ERGIC3	157	Annotation score:
A0A0C4DH46	A0A0C4DH46_HUMAN	Endoplasmic reticulum-Golgi interme... Endoplasmic reticulum-Golgi intermediate compartment protein 3	ERGIC3	123	Annotation score:
A0A1W2PPS8	A0A1W2PPS8_HUMAN	Endoplasmic reticulum-Golgi interme... Endoplasmic reticulum-Golgi intermediate compartment protein 3	ERGIC3	198	Annotation score:

Sequence cautionⁱ

The sequence AAF71038 differs from that shown. Reason: Erroneous initiation.Curated

The sequence AAG48265 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Sequence conflictⁱ	239	N → D in BAC11054 (PubMed:14702039).Curated		1

Natural variant

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Natural variantⁱVAR_048939	113	I → L. Corresponds to variant dbSNP:rs35505616Ensembl.		1
Natural variantⁱVAR_036553	297	T → K in a colorectal cancer sample; somatic mutation. 1 Publication		1

Alternative sequence

Feature key	Position(s)	DescriptionActions	Length
Alternative sequenceⁱVSP_008652	229 – 230	VH → GE in isoform 2. 1 Publication	2
Alternative sequenceⁱVSP_019208	229	V → VHAVEI in isoform 3. 1 Publication	1
Alternative sequenceⁱVSP_008653	231 – 383	Missing in isoform 2. 1 PublicationAdd BLAST	153

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AF308298 mRNA Translation: AAG48265.1 Different initiation. AF151812 mRNA Translation: AAD34049.1 AK074550 mRNA Translation: BAC11054.1 AF077030 mRNA Translation: AAD27763.1 AL121586 Genomic DNA Translation: CAB89412.1 AL121586 Genomic DNA Translation: CAI42842.1 BC009765 mRNA Translation: AAH09765.1 BC014014 mRNA Translation: AAH14014.1 AF116614 mRNA Translation: AAF71038.1 Different initiation.
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS13257.1 [Q9Y282-1] CCDS13258.1 [Q9Y282-3]
NCBI Reference Sequences More...RefSeqⁱ	NP_057050.1, NM_015966.2 [Q9Y282-1] NP_938408.1, NM_198398.1 [Q9Y282-3]
UniGeneⁱ	Hs.472558

Genome annotation databases

Ensemblⁱ	ENST00000348547; ENSP00000341358; ENSG00000125991 [Q9Y282-1] ENST00000357394; ENSP00000349970; ENSG00000125991 [Q9Y282-3]
GeneIDⁱ	51614
KEGGⁱ	hsa:51614
UCSC genome browser More...UCSCⁱ	uc002xcs.4 human [Q9Y282-1]

Keywords - Coding sequence diversityⁱ

Alternative splicing, Polymorphism

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
Q9Y282	ERGIC and golgi 3, isoform CRA_a		HUMAN		383	UniRef100_Q9Y282
ERGIC and golgi 3		MACMU		383
ERGIC and golgi 3		PANTR		383
ERGIC and golgi 3		COLAP		383
ERGIC3 isoform 1		PONAB		383
+8
Q9Y282-3	ERGIC and golgi 3, isoform 1 (Predicted)		PAPAN		388	UniRef100_B0CM80
ERGIC and golgi 3		PANTR		388
Endoplasmic reticulum-Golgi intermediate compartment protein 3 isoform a		MACMU		388
ERGIC and golgi 3		COLAP		388
ERGIC3 isoform 2		PONAB		388
+7

Protein	Similar proteins		Species	Score	Length	Source
Q9Y282	Endoplasmic reticulum-Golgi intermediate compartment protein 3		BOVIN		383	UniRef90_Q9Y282
Endoplasmic reticulum-Golgi intermediate compartment protein 3		MOUSE		383
Endoplasmic reticulum-Golgi intermediate compartment protein 3		PONAB		383
Endoplasmic reticulum-Golgi intermediate compartment protein 3		MACFA		382
ERGIC and golgi 3, isoform CRA_a		HUMAN		383
+217
Q9Y282-2	Isoform 3 of Endoplasmic reticulum-Golgi intermediate compartment protein 3		BOVIN		283	UniRef90_Q9Y282-2
ERGIC and golgi 3		MYOLU		231
Isoform 2 of Endoplasmic reticulum-Golgi intermediate compartment protein 3		BOVIN		231

Protein	Similar proteins		Species	Score	Length	Source
Q9Y282	Endoplasmic reticulum-Golgi intermediate compartment protein 3		PONAB		383	UniRef50_Q9Y282
Endoplasmic reticulum-Golgi intermediate compartment protein 3		MOUSE		383
Endoplasmic reticulum-Golgi intermediate compartment protein 3		BOVIN		383
Endoplasmic reticulum-Golgi intermediate compartment protein 3		MACFA		382
Endoplasmic reticulum-Golgi intermediate compartment protein 3		XENLA		389
+692
Q9Y282-2	Isoform 3 of Endoplasmic reticulum-Golgi intermediate compartment protein 3		BOVIN		283	UniRef50_Q9Y282-2
ERGIC and golgi 3		MYOLU		231
Endoplasmic reticulum-Golgi intermediate compartment protein 3-like		Asian bonytongue		332
Endoplasmic reticulum-Golgi intermediate compartment protein 3 (Fragment)		ANAPL		300
Chromosome undetermined SCAF13964, whole genome shotgun sequence		TETNG		299
+15

Entry informationⁱ

Entry nameⁱ	ERGI3_HUMAN
Accessionⁱ	Q9Y282Primary (citable) accession number: Q9Y282 Secondary accession number(s): Q5JWS3 , Q6ZWP7, Q9H276, Q9P1L3
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	October 24, 2003
	Last sequence update:	November 1, 1999
	Last modified:	September 12, 2018
	This is version 134 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

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UniParc

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UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - Q9Y282 (ERGI3_HUMAN)

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Endoplasmic reticulum-Golgi intermediate compartment protein 3

ERGIC3

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Endoplasmic reticulum

Golgi apparatus

Other locations

Endoplasmic reticulum

Golgi apparatus

Other locations

Topology

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Phylogenomic databases

Family and domain databases

Computationally mapped potential isoform sequencesi

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

Experimental Info

Natural variant

Alternative sequence

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

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Functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Computationally mapped potential isoform sequencesⁱ

Sequence cautionⁱ

Keywords - Coding sequence diversityⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ