Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Voltage-dependent anion-selective channel protein 3

Gene

VDAC3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Forms a channel through the mitochondrial outer membrane that allows diffusion of small hydrophilic molecules.By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi242 – 244NADBy similarity3
Nucleotide bindingi260 – 264NADBy similarity5

GO - Molecular functioni

  • nucleotide binding Source: UniProtKB-KW
  • porin activity Source: UniProtKB-KW
  • voltage-gated anion channel activity Source: UniProtKB

GO - Biological processi

Keywordsi

Molecular functionPorin
Biological processIon transport, Transport
LigandNAD, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-HSA-5689880 Ub-specific processing proteases
R-HSA-8949215 Mitochondrial calcium ion transport

Names & Taxonomyi

Protein namesi
Recommended name:
Voltage-dependent anion-selective channel protein 3
Short name:
VDAC-3
Short name:
hVDAC3
Alternative name(s):
Outer mitochondrial membrane protein porin 3
Gene namesi
Name:VDAC3
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 8

Organism-specific databases

EuPathDBiHostDB:ENSG00000078668.13
HGNCiHGNC:12674 VDAC3
MIMi610029 gene
neXtProtiNX_Q9Y277

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei26 – 35Beta strandedBy similarity10
Transmembranei39 – 47Beta strandedBy similarity9
Transmembranei54 – 64Beta strandedBy similarityAdd BLAST11
Transmembranei69 – 76Beta strandedBy similarity8
Transmembranei80 – 89Beta strandedBy similarity10
Transmembranei95 – 104Beta strandedBy similarity10
Transmembranei111 – 120Beta strandedBy similarity10
Transmembranei123 – 130Beta strandedBy similarity8
Transmembranei137 – 145Beta strandedBy similarity9
Transmembranei150 – 158Beta strandedBy similarity9
Transmembranei163 – 175Beta strandedBy similarityAdd BLAST13
Transmembranei178 – 185Beta strandedBy similarity8
Transmembranei189 – 198Beta strandedBy similarity10
Transmembranei202 – 211Beta strandedBy similarity10
Transmembranei218 – 227Beta strandedBy similarity10
Transmembranei231 – 238Beta strandedBy similarity8
Transmembranei242 – 251Beta strandedBy similarity10
Transmembranei254 – 263Beta strandedBy similarity10
Transmembranei273 – 282Beta strandedBy similarity10

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion outer membrane

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000078668
PharmGKBiPA37297

Chemistry databases

DrugBankiDB01375 Aluminium monostearate
DB06098 PRLX 93936

Polymorphism and mutation databases

BioMutaiVDAC3
DMDMi12643945

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedCombined sources
ChainiPRO_00000505122 – 283Voltage-dependent anion-selective channel protein 3Add BLAST282

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylcysteineCombined sources1
Modified residuei4PhosphothreonineCombined sources1
Modified residuei12N6-acetyllysineBy similarity1
Modified residuei15N6-acetyllysineBy similarity1
Modified residuei20N6-acetyllysineCombined sources1
Cross-linki53Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)1 Publication
Cross-linki61Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)1 Publication
Modified residuei90N6-acetyllysineCombined sources1
Cross-linki109Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)1 Publication
Cross-linki110Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)1 Publication
Cross-linki163Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)1 Publication
Modified residuei241PhosphoserineBy similarity1
Modified residuei266N6-acetyllysine; alternateBy similarity1
Cross-linki266Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin); alternate1 Publication
Cross-linki274Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)1 Publication

Post-translational modificationi

Ubiquitinated by PRKN during mitophagy, leading to its degradation and enhancement of mitophagy. Deubiquitinated by USP30.1 Publication

Keywords - PTMi

Acetylation, Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDiQ9Y277
PaxDbiQ9Y277
PeptideAtlasiQ9Y277
PRIDEiQ9Y277
ProteomicsDBi85680
85681 [Q9Y277-2]

2D gel databases

UCD-2DPAGEiQ9Y277

PTM databases

iPTMnetiQ9Y277
PhosphoSitePlusiQ9Y277
SwissPalmiQ9Y277

Expressioni

Tissue specificityi

Widely expressed. Highest in testis.

Gene expression databases

BgeeiENSG00000078668
CleanExiHS_VDAC3
ExpressionAtlasiQ9Y277 baseline and differential
GenevisibleiQ9Y277 HS

Organism-specific databases

HPAiHPA026864

Interactioni

Protein-protein interaction databases

BioGridi113262, 115 interactors
IntActiQ9Y277, 17 interactors
MINTiQ9Y277
STRINGi9606.ENSP00000428845

Structurei

3D structure databases

ProteinModelPortaliQ9Y277
SMRiQ9Y277
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domaini

Consists mainly of a membrane-spanning beta-barrel formed by 19 beta-strands.By similarity

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane beta strand

Phylogenomic databases

eggNOGiKOG3126 Eukaryota
ENOG410ZBK1 LUCA
GeneTreeiENSGT00390000011336
HOGENOMiHOG000188277
HOVERGENiHBG054036
InParanoidiQ9Y277
KOiK15041
OMAiWAVLGYE
OrthoDBiEOG091G0F0O
PhylomeDBiQ9Y277
TreeFamiTF315091

Family and domain databases

Gene3Di2.40.160.10, 1 hit
InterProiView protein in InterPro
IPR023614 Porin_dom_sf
IPR001925 Porin_Euk
IPR027246 Porin_Euk/Tom40
IPR030271 VDAC3
PANTHERiPTHR11743:SF28 PTHR11743:SF28, 1 hit
PfamiView protein in Pfam
PF01459 Porin_3, 1 hit
PRINTSiPR00185 EUKARYTPORIN
PROSITEiView protein in PROSITE
PS00558 EUKARYOTIC_PORIN, 1 hit

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9Y277-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MCNTPTYCDL GKAAKDVFNK GYGFGMVKID LKTKSCSGVE FSTSGHAYTD
60 70 80 90 100
TGKASGNLET KYKVCNYGLT FTQKWNTDNT LGTEISWENK LAEGLKLTLD
110 120 130 140 150
TIFVPNTGKK SGKLKASYKR DCFSVGSNVD IDFSGPTIYG WAVLAFEGWL
160 170 180 190 200
AGYQMSFDTA KSKLSQNNFA LGYKAADFQL HTHVNDGTEF GGSIYQKVNE
210 220 230 240 250
KIETSINLAW TAGSNNTRFG IAAKYMLDCR TSLSAKVNNA SLIGLGYTQT
260 270 280
LRPGVKLTLS ALIDGKNFSA GGHKVGLGFE LEA
Length:283
Mass (Da):30,659
Last modified:November 1, 1999 - v1
Checksum:iE03CBCEDA72A9783
GO
Isoform 2 (identifier: Q9Y277-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     39-39: V → VM

Show »
Length:284
Mass (Da):30,790
Checksum:i7AD0EBC72F3C1112
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_00507939V → VM in isoform 2. Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U90943 mRNA Translation: AAB93872.1
AF038962 mRNA Translation: AAC39876.1
BC056870 mRNA Translation: AAH56870.1
AH008073 Genomic DNA Translation: AAD49610.1
CCDSiCCDS47850.1 [Q9Y277-2]
CCDS6131.1 [Q9Y277-1]
RefSeqiNP_001129166.1, NM_001135694.2 [Q9Y277-2]
NP_005653.3, NM_005662.6 [Q9Y277-1]
UniGeneiHs.699301

Genome annotation databases

EnsembliENST00000022615; ENSP00000022615; ENSG00000078668 [Q9Y277-1]
ENST00000521158; ENSP00000428845; ENSG00000078668 [Q9Y277-2]
GeneIDi7419
KEGGihsa:7419
UCSCiuc003xpc.4 human [Q9Y277-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiVDAC3_HUMAN
AccessioniPrimary (citable) accession number: Q9Y277
Secondary accession number(s): Q9UIS0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: November 1, 1999
Last modified: June 20, 2018
This is version 162 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 8
    Human chromosome 8: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health