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Protein

Type 2 lactosamine alpha-2,3-sialyltransferase

Gene

ST3GAL6

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Involved in the synthesis of sialyl-paragloboside, a precursor of sialyl-Lewis X determinant. Has a alpha-2,3-sialyltransferase activity toward Gal-beta1,4-GlcNAc structure on glycoproteins and glycolipids. Has a restricted substrate specificity, it utilizes Gal-beta1,4-GlcNAc on glycoproteins, and neolactotetraosylceramide and neolactohexaosylceramide, but not lactotetraosylceramide, lactosylceramide or asialo-GM1.

GO - Molecular functioni

  • beta-galactoside (CMP) alpha-2,3-sialyltransferase activity Source: Reactome
  • beta-galactoside alpha-2,3-sialyltransferase activity Source: UniProtKB
  • sialyltransferase activity Source: GO_Central

GO - Biological processi

Keywordsi

Molecular functionGlycosyltransferase, Transferase

Enzyme and pathway databases

BioCyciMetaCyc:ENSG00000064225-MONOMER
BRENDAi2.4.99.10 2681
2.4.99.6 2681
ReactomeiR-HSA-1912420 Pre-NOTCH Processing in Golgi
R-HSA-2022854 Keratan sulfate biosynthesis
R-HSA-4085001 Sialic acid metabolism

Protein family/group databases

CAZyiGT29 Glycosyltransferase Family 29

Names & Taxonomyi

Protein namesi
Recommended name:
Type 2 lactosamine alpha-2,3-sialyltransferase (EC:2.4.99.-)
Alternative name(s):
CMP-NeuAc:beta-galactoside alpha-2,3-sialyltransferase VI
ST3Gal VI
Short name:
ST3GalVI
Sialyltransferase 10
Gene namesi
Name:ST3GAL6
Synonyms:SIAT10
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 3

Organism-specific databases

EuPathDBiHostDB:ENSG00000064225.12
HGNCiHGNC:18080 ST3GAL6
MIMi607156 gene
neXtProtiNX_Q9Y274

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 4CytoplasmicSequence analysis4
Transmembranei5 – 25Helical; Signal-anchor for type II membrane proteinSequence analysisAdd BLAST21
Topological domaini26 – 331LumenalSequence analysisAdd BLAST306

Keywords - Cellular componenti

Golgi apparatus, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi10402
OpenTargetsiENSG00000064225
PharmGKBiPA134958548

Polymorphism and mutation databases

DMDMi54039605

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001493051 – 331Type 2 lactosamine alpha-2,3-sialyltransferaseAdd BLAST331

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi129N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi181N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi282N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi295N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi308N-linked (GlcNAc...) asparagine1 Publication1
Glycosylationi327N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

EPDiQ9Y274
PaxDbiQ9Y274
PeptideAtlasiQ9Y274
PRIDEiQ9Y274
ProteomicsDBi85676

PTM databases

GlyConnecti1868
iPTMnetiQ9Y274
PhosphoSitePlusiQ9Y274

Expressioni

Tissue specificityi

Ubiquitous.

Gene expression databases

BgeeiENSG00000064225 Expressed in 215 organ(s), highest expression level in testis
CleanExiHS_ST3GAL6
ExpressionAtlasiQ9Y274 baseline and differential
GenevisibleiQ9Y274 HS

Organism-specific databases

HPAiHPA018792

Interactioni

Protein-protein interaction databases

BioGridi115674, 9 interactors
STRINGi9606.ENSP00000377717

Structurei

3D structure databases

ProteinModelPortaliQ9Y274
SMRiQ9Y274
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the glycosyltransferase 29 family.Curated

Keywords - Domaini

Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG2692 Eukaryota
ENOG410XT8P LUCA
GeneTreeiENSGT00760000119095
HOGENOMiHOG000000682
HOVERGENiHBG056676
InParanoidiQ9Y274
KOiK03792
PhylomeDBiQ9Y274
TreeFamiTF354325

Family and domain databases

Gene3Di3.90.1480.20, 1 hit
InterProiView protein in InterPro
IPR001675 Glyco_trans_29
IPR038578 GT29-like_sf
IPR012163 Sialyl_trans
PfamiView protein in Pfam
PF00777 Glyco_transf_29, 1 hit
PIRSFiPIRSF005557 Sialyl_trans, 1 hit

Sequences (2+)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 11 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q9Y274-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MRGYLVAIFL SAVFLYYVLH CILWGTNVYW VAPVEMKRRN KIQPCLSKPA
60 70 80 90 100
FASLLRFHQF HPFLCAADFR KIASLYGSDK FDLPYGMRTS AEYFRLALSK
110 120 130 140 150
LQSCDLFDEF DNIPCKKCVV VGNGGVLKNK TLGEKIDSYD VIIRMNNGPV
160 170 180 190 200
LGHEEEVGRR TTFRLFYPES VFSDPIHNDP NTTVILTAFK PHDLRWLLEL
210 220 230 240 250
LMGDKINTNG FWKKPALNLI YKPYQIRILD PFIIRTAAYE LLHFPKVFPK
260 270 280 290 300
NQKPKHPTTG IIAITLAFYI CHEVHLAGFK YNFSDLKSPL HYYGNATMSL
310 320 330
MNKNAYHNVT AEQLFLKDII EKNLVINLTQ D
Length:331
Mass (Da):38,214
Last modified:November 1, 1999 - v1
Checksum:iDD2B3D88D3D0A055
GO
Isoform 2 (identifier: Q9Y274-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-86: Missing.
     112-144: NIPCKKCVVVGNGGVLKNKTLGEKIDSYDVIIR → K

Show »
Length:213
Mass (Da):24,782
Checksum:i6AC0FDF802B3D8AF
GO

Computationally mapped potential isoform sequencesi

There are 11 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A087WXB8A0A087WXB8_HUMAN
ST3 beta-galactoside alpha-2,3-sial...
ST3GAL6 hCG_18894
384Annotation score:
C9J0E2C9J0E2_HUMAN
Type 2 lactosamine alpha-2,3-sialyl...
ST3GAL6
231Annotation score:
C9J480C9J480_HUMAN
Type 2 lactosamine alpha-2,3-sialyl...
ST3GAL6
262Annotation score:
C9IZL6C9IZL6_HUMAN
Type 2 lactosamine alpha-2,3-sialyl...
ST3GAL6
218Annotation score:
C9J9Y4C9J9Y4_HUMAN
Type 2 lactosamine alpha-2,3-sialyl...
ST3GAL6
165Annotation score:
C9JWJ3C9JWJ3_HUMAN
Type 2 lactosamine alpha-2,3-sialyl...
ST3GAL6
157Annotation score:
C9JXM2C9JXM2_HUMAN
Type 2 lactosamine alpha-2,3-sialyl...
ST3GAL6
121Annotation score:
C9JMW7C9JMW7_HUMAN
Type 2 lactosamine alpha-2,3-sialyl...
ST3GAL6
146Annotation score:
C9JWI9C9JWI9_HUMAN
Type 2 lactosamine alpha-2,3-sialyl...
ST3GAL6
101Annotation score:
F2Z2F4F2Z2F4_HUMAN
Type 2 lactosamine alpha-2,3-sialyl...
ST3GAL6
90Annotation score:
There is more potential isoformShow all

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti271C → S in BAG50993 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_049227311A → T. Corresponds to variant dbSNP:rs28489284Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0470091 – 86Missing in isoform 2. 1 PublicationAdd BLAST86
Alternative sequenceiVSP_047010112 – 144NIPCK…DVIIR → K in isoform 2. 1 PublicationAdd BLAST33

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB022918 mRNA Translation: BAA77609.1
AF119391 mRNA Translation: AAD39131.1
AK315111 mRNA Translation: BAG37569.1
AK001922 mRNA Translation: BAG50993.1
AC106728 Genomic DNA No translation available.
CH471052 Genomic DNA Translation: EAW79849.1
CH471052 Genomic DNA Translation: EAW79850.1
CH471052 Genomic DNA Translation: EAW79852.1
BC023312 mRNA Translation: AAH23312.1
CCDSiCCDS2933.1 [Q9Y274-1]
CCDS59452.1 [Q9Y274-2]
RefSeqiNP_001258074.1, NM_001271145.1
NP_001258075.1, NM_001271146.1 [Q9Y274-1]
NP_001258076.1, NM_001271147.1 [Q9Y274-2]
NP_001310281.1, NM_001323352.1 [Q9Y274-1]
NP_001310294.1, NM_001323365.1 [Q9Y274-1]
NP_001310297.1, NM_001323368.1 [Q9Y274-1]
NP_006091.1, NM_006100.3 [Q9Y274-1]
UniGeneiHs.148716

Genome annotation databases

EnsembliENST00000265261; ENSP00000265261; ENSG00000064225 [Q9Y274-2]
ENST00000394162; ENSP00000377717; ENSG00000064225 [Q9Y274-1]
ENST00000483910; ENSP00000417376; ENSG00000064225 [Q9Y274-1]
GeneIDi10402
KEGGihsa:10402
UCSCiuc003dsz.5 human [Q9Y274-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Cross-referencesi

Web resourcesi

Functional Glycomics Gateway - GTase

ST3Gal VI

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB022918 mRNA Translation: BAA77609.1
AF119391 mRNA Translation: AAD39131.1
AK315111 mRNA Translation: BAG37569.1
AK001922 mRNA Translation: BAG50993.1
AC106728 Genomic DNA No translation available.
CH471052 Genomic DNA Translation: EAW79849.1
CH471052 Genomic DNA Translation: EAW79850.1
CH471052 Genomic DNA Translation: EAW79852.1
BC023312 mRNA Translation: AAH23312.1
CCDSiCCDS2933.1 [Q9Y274-1]
CCDS59452.1 [Q9Y274-2]
RefSeqiNP_001258074.1, NM_001271145.1
NP_001258075.1, NM_001271146.1 [Q9Y274-1]
NP_001258076.1, NM_001271147.1 [Q9Y274-2]
NP_001310281.1, NM_001323352.1 [Q9Y274-1]
NP_001310294.1, NM_001323365.1 [Q9Y274-1]
NP_001310297.1, NM_001323368.1 [Q9Y274-1]
NP_006091.1, NM_006100.3 [Q9Y274-1]
UniGeneiHs.148716

3D structure databases

ProteinModelPortaliQ9Y274
SMRiQ9Y274
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi115674, 9 interactors
STRINGi9606.ENSP00000377717

Protein family/group databases

CAZyiGT29 Glycosyltransferase Family 29

PTM databases

GlyConnecti1868
iPTMnetiQ9Y274
PhosphoSitePlusiQ9Y274

Polymorphism and mutation databases

DMDMi54039605

Proteomic databases

EPDiQ9Y274
PaxDbiQ9Y274
PeptideAtlasiQ9Y274
PRIDEiQ9Y274
ProteomicsDBi85676

Protocols and materials databases

DNASUi10402
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000265261; ENSP00000265261; ENSG00000064225 [Q9Y274-2]
ENST00000394162; ENSP00000377717; ENSG00000064225 [Q9Y274-1]
ENST00000483910; ENSP00000417376; ENSG00000064225 [Q9Y274-1]
GeneIDi10402
KEGGihsa:10402
UCSCiuc003dsz.5 human [Q9Y274-1]

Organism-specific databases

CTDi10402
DisGeNETi10402
EuPathDBiHostDB:ENSG00000064225.12
GeneCardsiST3GAL6
HGNCiHGNC:18080 ST3GAL6
HPAiHPA018792
MIMi607156 gene
neXtProtiNX_Q9Y274
OpenTargetsiENSG00000064225
PharmGKBiPA134958548
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG2692 Eukaryota
ENOG410XT8P LUCA
GeneTreeiENSGT00760000119095
HOGENOMiHOG000000682
HOVERGENiHBG056676
InParanoidiQ9Y274
KOiK03792
PhylomeDBiQ9Y274
TreeFamiTF354325

Enzyme and pathway databases

BioCyciMetaCyc:ENSG00000064225-MONOMER
BRENDAi2.4.99.10 2681
2.4.99.6 2681
ReactomeiR-HSA-1912420 Pre-NOTCH Processing in Golgi
R-HSA-2022854 Keratan sulfate biosynthesis
R-HSA-4085001 Sialic acid metabolism

Miscellaneous databases

GenomeRNAii10402
PROiPR:Q9Y274
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000064225 Expressed in 215 organ(s), highest expression level in testis
CleanExiHS_ST3GAL6
ExpressionAtlasiQ9Y274 baseline and differential
GenevisibleiQ9Y274 HS

Family and domain databases

Gene3Di3.90.1480.20, 1 hit
InterProiView protein in InterPro
IPR001675 Glyco_trans_29
IPR038578 GT29-like_sf
IPR012163 Sialyl_trans
PfamiView protein in Pfam
PF00777 Glyco_transf_29, 1 hit
PIRSFiPIRSF005557 Sialyl_trans, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiSIA10_HUMAN
AccessioniPrimary (citable) accession number: Q9Y274
Secondary accession number(s): B2RCH2
, B3KMI1, D3DN39, F8W6U0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 5, 2004
Last sequence update: November 1, 1999
Last modified: November 7, 2018
This is version 137 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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