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Protein

Cysteinyl leukotriene receptor 1

Gene

CYSLTR1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Receptor for cysteinyl leukotrienes mediating bronchoconstriction of individuals with and without asthma. Stimulation by LTD4 results in the contraction and proliferation of smooth muscle, edema, eosinophil migration and damage to the mucus layer in the lung. This response is mediated via a G-protein that activates a phosphatidylinositol-calcium second messenger system. The rank order of affinities for the leukotrienes is LTD4 >> LTE4 = LTC4 >> LTB4.

Miscellaneous

Selective antagonists, such as montelukast (Singulair), zafirlukast (Accolate) and pranlukast (Onon), are used in the treatment of the asthma crisis.

GO - Molecular functioni

  • G-protein coupled peptide receptor activity Source: GO_Central
  • leukotriene receptor activity Source: ProtInc

GO - Biological processi

Keywordsi

Molecular functionG-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

ReactomeiR-HSA-391906 Leukotriene receptors
R-HSA-416476 G alpha (q) signalling events

Protein family/group databases

TCDBi9.A.14.13.2 the g-protein-coupled receptor (gpcr) family

Chemistry databases

SwissLipidsiSLP:000001582

Names & Taxonomyi

Protein namesi
Recommended name:
Cysteinyl leukotriene receptor 1
Short name:
CysLTR1
Alternative name(s):
Cysteinyl leukotriene D4 receptor
Short name:
LTD4 receptor
G-protein coupled receptor HG55
HMTMF81
Gene namesi
Name:CYSLTR1
Synonyms:CYSLT1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome X

Organism-specific databases

EuPathDBiHostDB:ENSG00000173198.5
HGNCiHGNC:17451 CYSLTR1
MIMi300201 gene
neXtProtiNX_Q9Y271

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 28ExtracellularSequence analysisAdd BLAST28
Transmembranei29 – 49Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini50 – 57CytoplasmicSequence analysis8
Transmembranei58 – 78Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini79 – 106ExtracellularSequence analysisAdd BLAST28
Transmembranei107 – 127Helical; Name=3Sequence analysisAdd BLAST21
Topological domaini128 – 141CytoplasmicSequence analysisAdd BLAST14
Transmembranei142 – 162Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini163 – 193ExtracellularSequence analysisAdd BLAST31
Transmembranei194 – 214Helical; Name=5Sequence analysisAdd BLAST21
Topological domaini215 – 230CytoplasmicSequence analysisAdd BLAST16
Transmembranei231 – 251Helical; Name=6Sequence analysisAdd BLAST21
Topological domaini252 – 276ExtracellularSequence analysisAdd BLAST25
Transmembranei277 – 297Helical; Name=7Sequence analysisAdd BLAST21
Topological domaini298 – 337CytoplasmicSequence analysisAdd BLAST40

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi10800
OpenTargetsiENSG00000173198
PharmGKBiPA38453

Chemistry databases

ChEMBLiCHEMBL1798
DrugBankiDB00587 Cinalukast
DB00471 Montelukast
DB00716 Nedocromil
DB01411 Pranlukast
DB00549 Zafirlukast
GuidetoPHARMACOLOGYi269

Polymorphism and mutation databases

DMDMi20138087

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000692991 – 337Cysteinyl leukotriene receptor 1Add BLAST337

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi6N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi96 ↔ 173PROSITE-ProRule annotation
Glycosylationi169N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi180N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi262N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

EPDiQ9Y271
PaxDbiQ9Y271
PeptideAtlasiQ9Y271
PRIDEiQ9Y271
ProteomicsDBi85673

PTM databases

iPTMnetiQ9Y271
PhosphoSitePlusiQ9Y271

Expressioni

Tissue specificityi

Widely expressed, with highest levels in spleen and peripheral blood leukocytes. Lower expression in several tissues, such as lung (mostly in smooth muscle bundles and alveolar macrophages), placenta, small intestine, pancreas, colon and heart.

Gene expression databases

BgeeiENSG00000173198
CleanExiHS_CYSLTR1
GenevisibleiQ9Y271 HS

Organism-specific databases

HPAiHPA010546

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
CYSLTR2Q9NS752EBI-9347754,EBI-3843579

Protein-protein interaction databases

BioGridi116014, 1 interactor
IntActiQ9Y271, 1 interactor
STRINGi9606.ENSP00000362401

Chemistry databases

BindingDBiQ9Y271

Structurei

3D structure databases

ProteinModelPortaliQ9Y271
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IKK2 Eukaryota
ENOG410XRU6 LUCA
GeneTreeiENSGT00920000148939
HOGENOMiHOG000236328
HOVERGENiHBG099611
InParanoidiQ9Y271
KOiK04322
OMAiPQDNQAK
OrthoDBiEOG091G0FE0
PhylomeDBiQ9Y271
TreeFamiTF350009

Family and domain databases

InterProiView protein in InterPro
IPR013310 CLT1_recept
IPR004071 Cyst_leuk_rcpt
IPR000276 GPCR_Rhodpsn
IPR017452 GPCR_Rhodpsn_7TM
PfamiView protein in Pfam
PF00001 7tm_1, 1 hit
PRINTSiPR01902 CYSLT1RECPTR
PR01533 CYSLTRECPTR
PR00237 GPCRRHODOPSN
PROSITEiView protein in PROSITE
PS50262 G_PROTEIN_RECEP_F1_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q9Y271-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDETGNLTVS SATCHDTIDD FRNQVYSTLY SMISVVGFFG NGFVLYVLIK
60 70 80 90 100
TYHKKSAFQV YMINLAVADL LCVCTLPLRV VYYVHKGIWL FGDFLCRLST
110 120 130 140 150
YALYVNLYCS IFFMTAMSFF RCIAIVFPVQ NINLVTQKKA RFVCVGIWIF
160 170 180 190 200
VILTSSPFLM AKPQKDEKNN TKCFEPPQDN QTKNHVLVLH YVSLFVGFII
210 220 230 240 250
PFVIIIVCYT MIILTLLKKS MKKNLSSHKK AIGMIMVVTA AFLVSFMPYH
260 270 280 290 300
IQRTIHLHFL HNETKPCDSV LRMQKSVVIT LSLAASNCCF DPLLYFFSGG
310 320 330
NFRKRLSTFR KHSLSSVTYV PRKKASLPEK GEEICKV
Length:337
Mass (Da):38,541
Last modified:November 1, 1999 - v1
Checksum:iB9B53940F895F245
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti272R → T in AAH35750 (PubMed:15489334).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF119711 mRNA Translation: AAD42285.1
AF133266 mRNA Translation: AAD42778.1
AY242130 Genomic DNA Translation: AAO92297.1
AK313643 mRNA Translation: BAG36401.1
AL445202 Genomic DNA No translation available.
CH471104 Genomic DNA Translation: EAW98598.1
CH471104 Genomic DNA Translation: EAW98599.1
BC035750 mRNA Translation: AAH35750.1
CCDSiCCDS14439.1
RefSeqiNP_001269115.1, NM_001282186.1
NP_001269116.1, NM_001282187.1
NP_001269117.1, NM_001282188.1
NP_006630.1, NM_006639.3
UniGeneiHs.733809

Genome annotation databases

EnsembliENST00000373304; ENSP00000362401; ENSG00000173198
ENST00000614798; ENSP00000478492; ENSG00000173198
GeneIDi10800
KEGGihsa:10800
UCSCiuc004edb.5 human

Similar proteinsi

Entry informationi

Entry nameiCLTR1_HUMAN
AccessioniPrimary (citable) accession number: Q9Y271
Secondary accession number(s): B2R954
, D3DTE4, Q5JS94, Q8IV19
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 11, 2002
Last sequence update: November 1, 1999
Last modified: June 20, 2018
This is version 146 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome X
    Human chromosome X: entries, gene names and cross-references to MIM
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. SIMILARITY comments
    Index of protein domains and families

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