UniProtKB - Q9Y271 (CLTR1_HUMAN)
Protein
Cysteinyl leukotriene receptor 1
Gene
CYSLTR1
Organism
Homo sapiens (Human)
Status
Functioni
Receptor for cysteinyl leukotrienes mediating bronchoconstriction of individuals with and without asthma. Stimulation by LTD4 results in the contraction and proliferation of smooth muscle, edema, eosinophil migration and damage to the mucus layer in the lung. This response is mediated via a G-protein that activates a phosphatidylinositol-calcium second messenger system. The rank order of affinities for the leukotrienes is LTD4 >> LTE4 = LTC4 >> LTB4.
Miscellaneous
Selective antagonists, such as montelukast (Singulair), zafirlukast (Accolate) and pranlukast (Onon), are used in the treatment of the asthma crisis.
GO - Molecular functioni
- cysteinyl leukotriene receptor activity Source: GO_Central
- G protein-coupled peptide receptor activity Source: GO_Central
- leukotriene receptor activity Source: ProtInc
GO - Biological processi
- calcium ion transport Source: Ensembl
- cell surface receptor signaling pathway Source: Ensembl
- chemotaxis Source: Ensembl
- defense response Source: ProtInc
- G protein-coupled receptor signaling pathway Source: Reactome
- inflammatory response to antigenic stimulus Source: Ensembl
- neuropeptide signaling pathway Source: GO_Central
- positive regulation of cytosolic calcium ion concentration Source: ProtInc
- respiratory gaseous exchange by respiratory system Source: ProtInc
Keywordsi
Molecular function | G-protein coupled receptor, Receptor, Transducer |
Enzyme and pathway databases
PathwayCommonsi | Q9Y271 |
Reactomei | R-HSA-391906, Leukotriene receptors R-HSA-416476, G alpha (q) signalling events R-HSA-9664535, LTC4-CYSLTR mediated IL4 production R-HSA-9679191, Potential therapeutics for SARS |
SIGNORi | Q9Y271 |
Protein family/group databases
TCDBi | 9.A.14.13.2, the g-protein-coupled receptor (gpcr) family |
Chemistry databases
SwissLipidsi | SLP:000001582 |
Names & Taxonomyi
Protein namesi | Recommended name: Cysteinyl leukotriene receptor 1Short name: CysLTR1 Alternative name(s): Cysteinyl leukotriene D4 receptor Short name: LTD4 receptor G-protein coupled receptor HG55 HMTMF81 |
Gene namesi | Name:CYSLTR1 Synonyms:CYSLT1 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
EuPathDBi | HostDB:ENSG00000173198.5 |
HGNCi | HGNC:17451, CYSLTR1 |
MIMi | 300201, gene |
neXtProti | NX_Q9Y271 |
Subcellular locationi
Plasma membrane
Plasma Membrane
- integral component of plasma membrane Source: GO_Central
- plasma membrane Source: Reactome
Other locations
- membrane Source: ProtInc
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 1 – 28 | ExtracellularSequence analysisAdd BLAST | 28 | |
Transmembranei | 29 – 49 | Helical; Name=1Sequence analysisAdd BLAST | 21 | |
Topological domaini | 50 – 57 | CytoplasmicSequence analysis | 8 | |
Transmembranei | 58 – 78 | Helical; Name=2Sequence analysisAdd BLAST | 21 | |
Topological domaini | 79 – 106 | ExtracellularSequence analysisAdd BLAST | 28 | |
Transmembranei | 107 – 127 | Helical; Name=3Sequence analysisAdd BLAST | 21 | |
Topological domaini | 128 – 141 | CytoplasmicSequence analysisAdd BLAST | 14 | |
Transmembranei | 142 – 162 | Helical; Name=4Sequence analysisAdd BLAST | 21 | |
Topological domaini | 163 – 193 | ExtracellularSequence analysisAdd BLAST | 31 | |
Transmembranei | 194 – 214 | Helical; Name=5Sequence analysisAdd BLAST | 21 | |
Topological domaini | 215 – 230 | CytoplasmicSequence analysisAdd BLAST | 16 | |
Transmembranei | 231 – 251 | Helical; Name=6Sequence analysisAdd BLAST | 21 | |
Topological domaini | 252 – 276 | ExtracellularSequence analysisAdd BLAST | 25 | |
Transmembranei | 277 – 297 | Helical; Name=7Sequence analysisAdd BLAST | 21 | |
Topological domaini | 298 – 337 | CytoplasmicSequence analysisAdd BLAST | 40 |
Keywords - Cellular componenti
Cell membrane, MembranePathology & Biotechi
Organism-specific databases
DisGeNETi | 10800 |
OpenTargetsi | ENSG00000173198 |
PharmGKBi | PA38453 |
Miscellaneous databases
Pharosi | Q9Y271, Tclin |
Chemistry databases
ChEMBLi | CHEMBL1798 |
DrugBanki | DB00587, Cinalukast DB08855, Leukotriene C4 DB11858, Leukotriene D4 DB00471, Montelukast DB00716, Nedocromil DB01411, Pranlukast DB00549, Zafirlukast |
DrugCentrali | Q9Y271 |
GuidetoPHARMACOLOGYi | 269 |
Polymorphism and mutation databases
BioMutai | CYSLTR1 |
DMDMi | 20138087 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000069299 | 1 – 337 | Cysteinyl leukotriene receptor 1Add BLAST | 337 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Glycosylationi | 6 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Disulfide bondi | 96 ↔ 173 | PROSITE-ProRule annotation | ||
Glycosylationi | 169 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 180 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 262 | N-linked (GlcNAc...) asparagineSequence analysis | 1 |
Keywords - PTMi
Disulfide bond, GlycoproteinProteomic databases
jPOSTi | Q9Y271 |
PaxDbi | Q9Y271 |
PeptideAtlasi | Q9Y271 |
PRIDEi | Q9Y271 |
ProteomicsDBi | 85673 |
PTM databases
GlyGeni | Q9Y271, 4 sites |
iPTMneti | Q9Y271 |
PhosphoSitePlusi | Q9Y271 |
Expressioni
Tissue specificityi
Widely expressed, with highest levels in spleen and peripheral blood leukocytes. Lower expression in several tissues, such as lung (mostly in smooth muscle bundles and alveolar macrophages), placenta, small intestine, pancreas, colon and heart.
Gene expression databases
Bgeei | ENSG00000173198, Expressed in bone marrow and 165 other tissues |
Genevisiblei | Q9Y271, HS |
Organism-specific databases
HPAi | ENSG00000173198, Tissue enhanced (blood, esophagus) |
Interactioni
Binary interactionsi
Q9Y271
With | #Exp. | IntAct |
---|---|---|
CYSLTR2 [Q9NS75] | 2 | EBI-9347754,EBI-3843579 |
Protein-protein interaction databases
BioGRIDi | 116014, 1 interactor |
IntActi | Q9Y271, 1 interactor |
STRINGi | 9606.ENSP00000478492 |
Chemistry databases
BindingDBi | Q9Y271 |
Miscellaneous databases
RNActi | Q9Y271, protein |
Structurei
Secondary structure
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details3D structure databases
SMRi | Q9Y271 |
ModBasei | Search... |
PDBe-KBi | Search... |
Family & Domainsi
Sequence similaritiesi
Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation
Keywords - Domaini
Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | ENOG502QUJU, Eukaryota |
GeneTreei | ENSGT01010000222255 |
HOGENOMi | CLU_009579_8_2_1 |
InParanoidi | Q9Y271 |
OMAi | PQDNQAK |
OrthoDBi | 390511at2759 |
PhylomeDBi | Q9Y271 |
TreeFami | TF350009 |
Family and domain databases
InterProi | View protein in InterPro IPR013310, CLT1_recept IPR004071, Cyst_leuk_rcpt IPR000276, GPCR_Rhodpsn IPR017452, GPCR_Rhodpsn_7TM |
Pfami | View protein in Pfam PF00001, 7tm_1, 1 hit |
PRINTSi | PR01902, CYSLT1RECPTR PR01533, CYSLTRECPTR PR00237, GPCRRHODOPSN |
PROSITEi | View protein in PROSITE PS50262, G_PROTEIN_RECEP_F1_2, 1 hit |
i Sequence
Sequence statusi: Complete.
Q9Y271-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MDETGNLTVS SATCHDTIDD FRNQVYSTLY SMISVVGFFG NGFVLYVLIK
60 70 80 90 100
TYHKKSAFQV YMINLAVADL LCVCTLPLRV VYYVHKGIWL FGDFLCRLST
110 120 130 140 150
YALYVNLYCS IFFMTAMSFF RCIAIVFPVQ NINLVTQKKA RFVCVGIWIF
160 170 180 190 200
VILTSSPFLM AKPQKDEKNN TKCFEPPQDN QTKNHVLVLH YVSLFVGFII
210 220 230 240 250
PFVIIIVCYT MIILTLLKKS MKKNLSSHKK AIGMIMVVTA AFLVSFMPYH
260 270 280 290 300
IQRTIHLHFL HNETKPCDSV LRMQKSVVIT LSLAASNCCF DPLLYFFSGG
310 320 330
NFRKRLSTFR KHSLSSVTYV PRKKASLPEK GEEICKV
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 272 | R → T in AAH35750 (PubMed:15489334).Curated | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF119711 mRNA Translation: AAD42285.1 AF133266 mRNA Translation: AAD42778.1 AY242130 Genomic DNA Translation: AAO92297.1 AK313643 mRNA Translation: BAG36401.1 AL445202 Genomic DNA No translation available. CH471104 Genomic DNA Translation: EAW98598.1 CH471104 Genomic DNA Translation: EAW98599.1 BC035750 mRNA Translation: AAH35750.1 |
CCDSi | CCDS14439.1 |
RefSeqi | NP_001269115.1, NM_001282186.1 NP_001269116.1, NM_001282187.1 NP_001269117.1, NM_001282188.1 NP_006630.1, NM_006639.3 |
Genome annotation databases
Ensembli | ENST00000373304; ENSP00000362401; ENSG00000173198 ENST00000614798; ENSP00000478492; ENSG00000173198 |
GeneIDi | 10800 |
KEGGi | hsa:10800 |
UCSCi | uc004edb.5, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF119711 mRNA Translation: AAD42285.1 AF133266 mRNA Translation: AAD42778.1 AY242130 Genomic DNA Translation: AAO92297.1 AK313643 mRNA Translation: BAG36401.1 AL445202 Genomic DNA No translation available. CH471104 Genomic DNA Translation: EAW98598.1 CH471104 Genomic DNA Translation: EAW98599.1 BC035750 mRNA Translation: AAH35750.1 |
CCDSi | CCDS14439.1 |
RefSeqi | NP_001269115.1, NM_001282186.1 NP_001269116.1, NM_001282187.1 NP_001269117.1, NM_001282188.1 NP_006630.1, NM_006639.3 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
6RZ4 | X-ray | 2.70 | A | 1-311 | [»] | |
6RZ5 | X-ray | 2.53 | A/B | 1-311 | [»] | |
SMRi | Q9Y271 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 116014, 1 interactor |
IntActi | Q9Y271, 1 interactor |
STRINGi | 9606.ENSP00000478492 |
Chemistry databases
BindingDBi | Q9Y271 |
ChEMBLi | CHEMBL1798 |
DrugBanki | DB00587, Cinalukast DB08855, Leukotriene C4 DB11858, Leukotriene D4 DB00471, Montelukast DB00716, Nedocromil DB01411, Pranlukast DB00549, Zafirlukast |
DrugCentrali | Q9Y271 |
GuidetoPHARMACOLOGYi | 269 |
SwissLipidsi | SLP:000001582 |
Protein family/group databases
TCDBi | 9.A.14.13.2, the g-protein-coupled receptor (gpcr) family |
GPCRDBi | Search... |
PTM databases
GlyGeni | Q9Y271, 4 sites |
iPTMneti | Q9Y271 |
PhosphoSitePlusi | Q9Y271 |
Polymorphism and mutation databases
BioMutai | CYSLTR1 |
DMDMi | 20138087 |
Proteomic databases
jPOSTi | Q9Y271 |
PaxDbi | Q9Y271 |
PeptideAtlasi | Q9Y271 |
PRIDEi | Q9Y271 |
ProteomicsDBi | 85673 |
Protocols and materials databases
Antibodypediai | 548, 308 antibodies |
DNASUi | 10800 |
Genome annotation databases
Ensembli | ENST00000373304; ENSP00000362401; ENSG00000173198 ENST00000614798; ENSP00000478492; ENSG00000173198 |
GeneIDi | 10800 |
KEGGi | hsa:10800 |
UCSCi | uc004edb.5, human |
Organism-specific databases
CTDi | 10800 |
DisGeNETi | 10800 |
EuPathDBi | HostDB:ENSG00000173198.5 |
GeneCardsi | CYSLTR1 |
HGNCi | HGNC:17451, CYSLTR1 |
HPAi | ENSG00000173198, Tissue enhanced (blood, esophagus) |
MIMi | 300201, gene |
neXtProti | NX_Q9Y271 |
OpenTargetsi | ENSG00000173198 |
PharmGKBi | PA38453 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | ENOG502QUJU, Eukaryota |
GeneTreei | ENSGT01010000222255 |
HOGENOMi | CLU_009579_8_2_1 |
InParanoidi | Q9Y271 |
OMAi | PQDNQAK |
OrthoDBi | 390511at2759 |
PhylomeDBi | Q9Y271 |
TreeFami | TF350009 |
Enzyme and pathway databases
PathwayCommonsi | Q9Y271 |
Reactomei | R-HSA-391906, Leukotriene receptors R-HSA-416476, G alpha (q) signalling events R-HSA-9664535, LTC4-CYSLTR mediated IL4 production R-HSA-9679191, Potential therapeutics for SARS |
SIGNORi | Q9Y271 |
Miscellaneous databases
BioGRID-ORCSi | 10800, 5 hits in 470 CRISPR screens |
ChiTaRSi | CYSLTR1, human |
GeneWikii | Cysteinyl_leukotriene_receptor_1 |
GenomeRNAii | 10800 |
Pharosi | Q9Y271, Tclin |
PROi | PR:Q9Y271 |
RNActi | Q9Y271, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000173198, Expressed in bone marrow and 165 other tissues |
Genevisiblei | Q9Y271, HS |
Family and domain databases
InterProi | View protein in InterPro IPR013310, CLT1_recept IPR004071, Cyst_leuk_rcpt IPR000276, GPCR_Rhodpsn IPR017452, GPCR_Rhodpsn_7TM |
Pfami | View protein in Pfam PF00001, 7tm_1, 1 hit |
PRINTSi | PR01902, CYSLT1RECPTR PR01533, CYSLTRECPTR PR00237, GPCRRHODOPSN |
PROSITEi | View protein in PROSITE PS50262, G_PROTEIN_RECEP_F1_2, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | CLTR1_HUMAN | |
Accessioni | Q9Y271Primary (citable) accession number: Q9Y271 Secondary accession number(s): B2R954 Q8IV19 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | February 11, 2002 |
Last sequence update: | November 1, 1999 | |
Last modified: | December 2, 2020 | |
This is version 165 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families - Human chromosome X
Human chromosome X: entries, gene names and cross-references to MIM - 7-transmembrane G-linked receptors
List of 7-transmembrane G-linked receptor entries