CYSLTR1

Functionⁱ

Receptor for cysteinyl leukotrienes mediating bronchoconstriction of individuals with and without asthma. Stimulation by LTD4 results in the contraction and proliferation of smooth muscle, edema, eosinophil migration and damage to the mucus layer in the lung. This response is mediated via a G-protein that activates a phosphatidylinositol-calcium second messenger system. The rank order of affinities for the leukotrienes is LTD4 >> LTE4 = LTC4 >> LTB4.

Miscellaneous

Selective antagonists, such as montelukast (Singulair), zafirlukast (Accolate) and pranlukast (Onon), are used in the treatment of the asthma crisis.

GO - Molecular functionⁱ

galanin receptor activity
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
G protein-coupled peptide receptor activity
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
leukotriene receptor activity
Source: ProtInc
Traceable author statementⁱ
- 10391245

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

calcium ion transport Source: Ensembl
cell surface receptor signaling pathway Source: Ensembl
chemotaxis Source: Ensembl
defense response
Source: ProtInc
Traceable author statementⁱ
- 10391245
G protein-coupled receptor signaling pathway Source: Reactome
inflammatory response to antigenic stimulus Source: Ensembl
neuropeptide signaling pathway
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
positive regulation of cytosolic calcium ion concentration
Source: ProtInc
Traceable author statementⁱ
- 10391245
respiratory gaseous exchange
Source: ProtInc
Traceable author statementⁱ
- 10391245

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	G-protein coupled receptor, Receptor, Transducer

Molecular function

G-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

Reactomeⁱ	R-HSA-391906 Leukotriene receptors R-HSA-416476 G alpha (q) signalling events

Reactomeⁱ

R-HSA-391906 Leukotriene receptors
R-HSA-416476 G alpha (q) signalling events

Protein family/group databases

TCDBⁱ

9.A.14.13.2 the g-protein-coupled receptor (gpcr) family

Chemistry databases

SwissLipidsⁱ	SLP:000001582

SwissLipidsⁱ

SLP:000001582

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Cysteinyl leukotriene receptor 1 Short name: CysLTR1 Alternative name(s): Cysteinyl leukotriene D4 receptor Short name: LTD4 receptor G-protein coupled receptor HG55 HMTMF81
Gene namesⁱ	Name:CYSLTR1 Synonyms:CYSLT1
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome X

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000173198.5
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:17451 CYSLTR1
MIMⁱ	300201 gene
neXtProtⁱ	NX_Q9Y271

Topology

Feature key	Position(s)	DescriptionActions	Length
Topological domainⁱ	1 – 28	ExtracellularSequence analysisAdd BLAST	28
Transmembraneⁱ	29 – 49	Helical; Name=1Sequence analysisAdd BLAST	21
Topological domainⁱ	50 – 57	CytoplasmicSequence analysis	8
Transmembraneⁱ	58 – 78	Helical; Name=2Sequence analysisAdd BLAST	21
Topological domainⁱ	79 – 106	ExtracellularSequence analysisAdd BLAST	28
Transmembraneⁱ	107 – 127	Helical; Name=3Sequence analysisAdd BLAST	21
Topological domainⁱ	128 – 141	CytoplasmicSequence analysisAdd BLAST	14
Transmembraneⁱ	142 – 162	Helical; Name=4Sequence analysisAdd BLAST	21
Topological domainⁱ	163 – 193	ExtracellularSequence analysisAdd BLAST	31
Transmembraneⁱ	194 – 214	Helical; Name=5Sequence analysisAdd BLAST	21
Topological domainⁱ	215 – 230	CytoplasmicSequence analysisAdd BLAST	16
Transmembraneⁱ	231 – 251	Helical; Name=6Sequence analysisAdd BLAST	21
Topological domainⁱ	252 – 276	ExtracellularSequence analysisAdd BLAST	25
Transmembraneⁱ	277 – 297	Helical; Name=7Sequence analysisAdd BLAST	21
Topological domainⁱ	298 – 337	CytoplasmicSequence analysisAdd BLAST	40

Keywords - Cellular componentⁱ

Cell membrane, Membrane

Pathology & Biotechⁱ

Organism-specific databases

DisGeNET More...DisGeNETⁱ	10800
Open Targets More...OpenTargetsⁱ	ENSG00000173198
PharmGKBⁱ	PA38453

Chemistry databases

ChEMBLⁱ	CHEMBL1798
Drug and drug target database More...DrugBankⁱ	DB00587 Cinalukast DB00471 Montelukast DB00716 Nedocromil DB01411 Pranlukast DB00549 Zafirlukast
IUPHAR/BPS Guide to PHARMACOLOGY More...GuidetoPHARMACOLOGYⁱ	269

Polymorphism and mutation databases

DMDMⁱ	20138087

DMDMⁱ

20138087

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000069299	1 – 337	Cysteinyl leukotriene receptor 1Add BLAST		337

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Glycosylationⁱ	6	N-linked (GlcNAc...) asparagineSequence analysis	1
Disulfide bondⁱ	96 ↔ 173	PROSITE-ProRule annotation
Glycosylationⁱ	169	N-linked (GlcNAc...) asparagineSequence analysis	1
Glycosylationⁱ	180	N-linked (GlcNAc...) asparagineSequence analysis	1
Glycosylationⁱ	262	N-linked (GlcNAc...) asparagineSequence analysis	1

Keywords - PTMⁱ

Disulfide bond, Glycoprotein

Proteomic databases

EPDⁱ	Q9Y271
PaxDbⁱ	Q9Y271
PeptideAtlas More...PeptideAtlasⁱ	Q9Y271
PRIDEⁱ	Q9Y271
ProteomicsDBⁱ	85673

PTM databases

iPTMnetⁱ	Q9Y271
PhosphoSitePlusⁱ	Q9Y271

Expressionⁱ

Tissue specificityⁱ

Widely expressed, with highest levels in spleen and peripheral blood leukocytes. Lower expression in several tissues, such as lung (mostly in smooth muscle bundles and alveolar macrophages), placenta, small intestine, pancreas, colon and heart.

Gene expression databases

Bgeeⁱ	ENSG00000173198 Expressed in 145 organ(s), highest expression level in bone marrow
CleanExⁱ	HS_CYSLTR1
Genevisibleⁱ	Q9Y271 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA010546

HPAⁱ

HPA010546

Interactionⁱ

Binary interactionsⁱ

With	Entry	#Exp.	IntAct	Notes
CYSLTR2	Q9NS75	2	EBI-9347754,EBI-3843579

With

Entry

#Exp.

IntAct

Notes

CYSLTR2

Q9NS75

2

EBI-9347754,EBI-3843579

Protein-protein interaction databases

BioGridⁱ	116014, 1 interactor
IntActⁱ	Q9Y271, 1 interactor
STRINGⁱ	9606.ENSP00000362401

Chemistry databases

BindingDBⁱ

Q9Y271

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q9Y271
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Sequence similaritiesⁱ

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domainⁱ

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGⁱ	ENOG410IKK2 Eukaryota ENOG410XRU6 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00920000148939
HOGENOMⁱ	HOG000236328
HOVERGENⁱ	HBG099611
InParanoidⁱ	Q9Y271
KEGG Orthology (KO) More...KOⁱ	K04322
OMAⁱ	PQDNQAK
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0FE0
PhylomeDBⁱ	Q9Y271
TreeFamⁱ	TF350009

Family and domain databases

InterProⁱ	View protein in InterPro IPR013310 CLT1_recept IPR004071 Cyst_leuk_rcpt IPR000276 GPCR_Rhodpsn IPR017452 GPCR_Rhodpsn_7TM
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00001 7tm_1, 1 hit
PRINTSⁱ	PR01902 CYSLT1RECPTR PR01533 CYSLTRECPTR PR00237 GPCRRHODOPSN
PROSITEⁱ	View protein in PROSITE PS50262 G_PROTEIN_RECEP_F1_2, 1 hit

Sequenceⁱ

Sequence statusⁱ: Complete.

Q9Y271-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MDETGNLTVS SATCHDTIDD FRNQVYSTLY SMISVVGFFG NGFVLYVLIK 
        60         70         80         90        100
TYHKKSAFQV YMINLAVADL LCVCTLPLRV VYYVHKGIWL FGDFLCRLST 
       110        120        130        140        150
YALYVNLYCS IFFMTAMSFF RCIAIVFPVQ NINLVTQKKA RFVCVGIWIF 
       160        170        180        190        200
VILTSSPFLM AKPQKDEKNN TKCFEPPQDN QTKNHVLVLH YVSLFVGFII 
       210        220        230        240        250
PFVIIIVCYT MIILTLLKKS MKKNLSSHKK AIGMIMVVTA AFLVSFMPYH 
       260        270        280        290        300
IQRTIHLHFL HNETKPCDSV LRMQKSVVIT LSLAASNCCF DPLLYFFSGG 
       310        320        330 
NFRKRLSTFR KHSLSSVTYV PRKKASLPEK GEEICKV

Length:337

Mass (Da):38,541

Last modified:November 1, 1999 - v1

Checksum:ⁱB9B53940F895F245

GO

Experimental Info

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Sequence conflictⁱ	272	R → T in AAH35750 (PubMed:15489334).Curated		1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AF119711 mRNA Translation: AAD42285.1 AF133266 mRNA Translation: AAD42778.1 AY242130 Genomic DNA Translation: AAO92297.1 AK313643 mRNA Translation: BAG36401.1 AL445202 Genomic DNA No translation available. CH471104 Genomic DNA Translation: EAW98598.1 CH471104 Genomic DNA Translation: EAW98599.1 BC035750 mRNA Translation: AAH35750.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS14439.1
NCBI Reference Sequences More...RefSeqⁱ	NP_001269115.1, NM_001282186.1 NP_001269116.1, NM_001282187.1 NP_001269117.1, NM_001282188.1 NP_006630.1, NM_006639.3
UniGeneⁱ	Hs.733809

Genome annotation databases

Ensemblⁱ	ENST00000373304; ENSP00000362401; ENSG00000173198 ENST00000614798; ENSP00000478492; ENSG00000173198
GeneIDⁱ	10800
KEGGⁱ	hsa:10800
UCSC genome browser More...UCSCⁱ	uc004edb.5 human

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
Q9Y271	Cysteinyl leukotriene receptor 1 splice variant IV (Fragment)		HUMAN		22	UniRef100_Q9Y271
Cysteinyl leukotriene receptor 1 (Fragment)		MACMU		79
Cysteinyl leukotriene receptor 1 splice variant V (Fragment)		HUMAN		23

Protein	Similar proteins		Species	Score	Length	Source
Q9Y271	Cysteinyl leukotriene receptor 1 splice variant IV (Fragment)		HUMAN		22	UniRef90_Q9Y271
Cysteinyl leukotriene receptor 1 (Fragment)		MACMU		79
Uncharacterized protein		RABIT		342
Cysteinyl leukotriene receptor 1		TUPCH		340
LOW QUALITY PROTEIN: cysteinyl leukotriene receptor 1		Enhydra lutris kenyoni		340
+86

Protein	Similar proteins		Species	Score	Length	Source
Q9Y271	Cysteinyl leukotriene receptor 1		MOUSE		352	UniRef50_Q9Y271
Cysteinyl leukotriene receptor 1		RAT		339
Cysteinyl leukotriene receptor 1 splice variant IV (Fragment)		HUMAN		22
Cysteinyl leukotriene receptor 1 (Fragment)		MACMU		79
Uncharacterized protein		RABIT		342
+209

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AF119711 mRNA Translation: AAD42285.1 AF133266 mRNA Translation: AAD42778.1 AY242130 Genomic DNA Translation: AAO92297.1 AK313643 mRNA Translation: BAG36401.1 AL445202 Genomic DNA No translation available. CH471104 Genomic DNA Translation: EAW98598.1 CH471104 Genomic DNA Translation: EAW98599.1 BC035750 mRNA Translation: AAH35750.1
CCDSⁱ	CCDS14439.1
RefSeqⁱ	NP_001269115.1, NM_001282186.1 NP_001269116.1, NM_001282187.1 NP_001269117.1, NM_001282188.1 NP_006630.1, NM_006639.3
UniGeneⁱ	Hs.733809

3D structure databases

ProteinModelPortalⁱ	Q9Y271
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	116014, 1 interactor
IntActⁱ	Q9Y271, 1 interactor
STRINGⁱ	9606.ENSP00000362401

Chemistry databases

BindingDBⁱ	Q9Y271
ChEMBLⁱ	CHEMBL1798
DrugBankⁱ	DB00587 Cinalukast DB00471 Montelukast DB00716 Nedocromil DB01411 Pranlukast DB00549 Zafirlukast
GuidetoPHARMACOLOGYⁱ	269
SwissLipidsⁱ	SLP:000001582

Protein family/group databases

TCDBⁱ	9.A.14.13.2 the g-protein-coupled receptor (gpcr) family
GPCRDBⁱ	Search...

PTM databases

iPTMnetⁱ	Q9Y271
PhosphoSitePlusⁱ	Q9Y271

Polymorphism and mutation databases

DMDMⁱ	20138087

DMDMⁱ

20138087

Proteomic databases

EPDⁱ	Q9Y271
PaxDbⁱ	Q9Y271
PeptideAtlasⁱ	Q9Y271
PRIDEⁱ	Q9Y271
ProteomicsDBⁱ	85673

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	10800
Structural Biology Knowledgebase	Search...

Genome annotation databases

Ensemblⁱ	ENST00000373304; ENSP00000362401; ENSG00000173198 ENST00000614798; ENSP00000478492; ENSG00000173198
GeneIDⁱ	10800
KEGGⁱ	hsa:10800
UCSCⁱ	uc004edb.5 human

Organism-specific databases

CTDⁱ	10800
DisGeNETⁱ	10800
EuPathDBⁱ	HostDB:ENSG00000173198.5
GeneCardsⁱ	CYSLTR1
HGNCⁱ	HGNC:17451 CYSLTR1
HPAⁱ	HPA010546
MIMⁱ	300201 gene
neXtProtⁱ	NX_Q9Y271
OpenTargetsⁱ	ENSG00000173198
PharmGKBⁱ	PA38453
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	ENOG410IKK2 Eukaryota ENOG410XRU6 LUCA
GeneTreeⁱ	ENSGT00920000148939
HOGENOMⁱ	HOG000236328
HOVERGENⁱ	HBG099611
InParanoidⁱ	Q9Y271
KOⁱ	K04322
OMAⁱ	PQDNQAK
OrthoDBⁱ	EOG091G0FE0
PhylomeDBⁱ	Q9Y271
TreeFamⁱ	TF350009

Enzyme and pathway databases

Reactomeⁱ	R-HSA-391906 Leukotriene receptors R-HSA-416476 G alpha (q) signalling events

Reactomeⁱ

R-HSA-391906 Leukotriene receptors
R-HSA-416476 G alpha (q) signalling events

Miscellaneous databases

GeneWikiⁱ	Cysteinyl_leukotriene_receptor_1
GenomeRNAiⁱ	10800
Protein Ontology More...PROⁱ	PR:Q9Y271
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000173198 Expressed in 145 organ(s), highest expression level in bone marrow
CleanExⁱ	HS_CYSLTR1
Genevisibleⁱ	Q9Y271 HS

Family and domain databases

InterProⁱ	View protein in InterPro IPR013310 CLT1_recept IPR004071 Cyst_leuk_rcpt IPR000276 GPCR_Rhodpsn IPR017452 GPCR_Rhodpsn_7TM
Pfamⁱ	View protein in Pfam PF00001 7tm_1, 1 hit
PRINTSⁱ	PR01902 CYSLT1RECPTR PR01533 CYSLTRECPTR PR00237 GPCRRHODOPSN
PROSITEⁱ	View protein in PROSITE PS50262 G_PROTEIN_RECEP_F1_2, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	CLTR1_HUMAN
Accessionⁱ	Q9Y271Primary (citable) accession number: Q9Y271 Secondary accession number(s): B2R954 , D3DTE4, Q5JS94, Q8IV19
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	February 11, 2002
	Last sequence update:	November 1, 1999
	Last modified:	November 7, 2018
	This is version 148 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
Human chromosome X
Human chromosome X: entries, gene names and cross-references to MIM
7-transmembrane G-linked receptors
List of 7-transmembrane G-linked receptor entries

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UniProtKB - Q9Y271 (CLTR1_HUMAN)

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Cysteinyl leukotriene receptor 1

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Miscellaneous

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

Protein family/group databases

Chemistry databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Plasma membrane

Plasma Membrane

Other locations

Topology

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Chemistry databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

Chemistry databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Phylogenomic databases

Family and domain databases

Experimental Info

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

Chemistry databases

Protein family/group databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ