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Protein

Solute carrier family 22 member 14

Gene

SLC22A14

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

GO - Biological processi

  • organic cation transport Source: UniProtKB
  • sodium-independent organic anion transport Source: GO_Central

Protein family/group databases

TCDBi2.A.1.19.22 the major facilitator superfamily (mfs)

Names & Taxonomyi

Protein namesi
Recommended name:
Solute carrier family 22 member 14
Alternative name(s):
Organic cation transporter-like 4
Short name:
ORCTL-4
Gene namesi
Name:SLC22A14
Synonyms:OCTL2, ORCTL4
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 3

Organism-specific databases

EuPathDBiHostDB:ENSG00000144671.10
HGNCiHGNC:8495 SLC22A14
MIMi604048 gene
neXtProtiNX_Q9Y267

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 70CytoplasmicSequence analysisAdd BLAST70
Transmembranei71 – 91HelicalSequence analysisAdd BLAST21
Topological domaini92 – 184ExtracellularSequence analysisAdd BLAST93
Transmembranei185 – 205HelicalSequence analysisAdd BLAST21
Topological domaini206 – 210CytoplasmicSequence analysis5
Transmembranei211 – 231HelicalSequence analysisAdd BLAST21
Topological domaini232 – 235ExtracellularSequence analysis4
Transmembranei236 – 256HelicalSequence analysisAdd BLAST21
Topological domaini257 – 270CytoplasmicSequence analysisAdd BLAST14
Transmembranei271 – 291HelicalSequence analysisAdd BLAST21
Topological domaini292 – 297ExtracellularSequence analysis6
Transmembranei298 – 318HelicalSequence analysisAdd BLAST21
Topological domaini319 – 379CytoplasmicSequence analysisAdd BLAST61
Transmembranei380 – 400HelicalSequence analysisAdd BLAST21
Topological domaini401 – 408ExtracellularSequence analysis8
Transmembranei409 – 431HelicalSequence analysisAdd BLAST23
Topological domaini432 – 437CytoplasmicSequence analysis6
Transmembranei438 – 458HelicalSequence analysisAdd BLAST21
Topological domaini459 – 488ExtracellularSequence analysisAdd BLAST30
Transmembranei489 – 509HelicalSequence analysisAdd BLAST21
Topological domaini510 – 512CytoplasmicSequence analysis3
Transmembranei513 – 533HelicalSequence analysisAdd BLAST21
Topological domaini534 – 538ExtracellularSequence analysis5
Transmembranei539 – 559HelicalSequence analysisAdd BLAST21
Topological domaini560 – 594CytoplasmicSequence analysisAdd BLAST35

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi9389
OpenTargetsiENSG00000144671
PharmGKBiPA32815

Polymorphism and mutation databases

BioMutaiSLC22A14
DMDMi313104317

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002307841 – 594Solute carrier family 22 member 14Add BLAST594

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi99N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi117N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi125N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi150N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ9Y267
PeptideAtlasiQ9Y267
PRIDEiQ9Y267
ProteomicsDBi85672

PTM databases

iPTMnetiQ9Y267
PhosphoSitePlusiQ9Y267

Expressioni

Tissue specificityi

Ubiquitous.1 Publication

Gene expression databases

BgeeiENSG00000144671
CleanExiHS_SLC22A14
ExpressionAtlasiQ9Y267 baseline and differential
GenevisibleiQ9Y267 HS

Interactioni

Protein-protein interaction databases

IntActiQ9Y267, 1 interactor
STRINGi9606.ENSP00000273173

Structurei

3D structure databases

ProteinModelPortaliQ9Y267
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IRHZ Eukaryota
ENOG410XQIT LUCA
GeneTreeiENSGT00760000118852
HOGENOMiHOG000234569
HOVERGENiHBG108434
InParanoidiQ9Y267
KOiK08210
OMAiRLCCIFL
OrthoDBiEOG091G07EF
PhylomeDBiQ9Y267
TreeFamiTF315847

Family and domain databases

CDDicd06174 MFS, 1 hit
InterProiView protein in InterPro
IPR020846 MFS_dom
IPR005828 MFS_sugar_transport-like
IPR036259 MFS_trans_sf
PfamiView protein in Pfam
PF00083 Sugar_tr, 1 hit
SUPFAMiSSF103473 SSF103473, 1 hit
PROSITEiView protein in PROSITE
PS50850 MFS, 1 hit

Sequencei

Sequence statusi: Complete.

Q9Y267-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAGEENFKEE LRSQDASRNL NQHEVAGHPH SWSLEMLLRR LRAVHTKQDD
60 70 80 90 100
KFANLLDAVG EFGTFQQRLV ALTFIPSIMS AFFMFADHFV FTAQKPYCNT
110 120 130 140 150
SWILAVGPHL SKAEQLNLTI PQAPNGSFLT CFMYLPVPWN LDSIIQFGLN
160 170 180 190 200
DTDTCQDGWI YPDAKKRSLI NEFDLVCGME TKKDTAQIMF MAGLPIGSLI
210 220 230 240 250
FRLITDKMGR YPAILLSLLG LIIFGFGTAF MNSFHLYLFF RFGISQSVVG
260 270 280 290 300
YAISSISLAT EWLVGEHRAH AIILGHCFFA VGAVLLTGIA YSLPHWQLLF
310 320 330 340 350
LVGGILVIPF ISYIWILPES PRWLMMKGKV KEAKQVLCYA ASVNKKTIPS
360 370 380 390 400
NLLDELQLPR KKVTRASVLD FCKNRQLCKV TLVMSCVWFT VSYTYFTLSL
410 420 430 440 450
RMRELGVSVH FRHVVPSIME VPARLCCIFL LQQIGRKWSL AVTLLQAIIW
460 470 480 490 500
CLLLLFLPEG EDGLRLKWPR CPATELKSMT ILVLMLREFS LAATVTVFFL
510 520 530 540 550
YTAELLPTVL RATGLGLVSL ASVAGAILSL TIISQTPSLL PIFLCCVLAI
560 570 580 590
VAFSLSSLLP ETRDQPLSES LNHSSQIRNK VKDMKTKETS SDDV
Length:594
Mass (Da):66,684
Last modified:November 30, 2010 - v4
Checksum:i7EA290B06222B681
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti282G → W in BAA76351 (PubMed:10072596).Curated1
Sequence conflicti282G → W in BAA77626 (PubMed:10231028).Curated1
Sequence conflicti470R → H in BAG37720 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_055108108P → H. Corresponds to variant dbSNP:rs9847584Ensembl.1
Natural variantiVAR_055109112K → E. Corresponds to variant dbSNP:rs2073714Ensembl.1
Natural variantiVAR_055110144I → T2 PublicationsCorresponds to variant dbSNP:rs194685Ensembl.1
Natural variantiVAR_055111245S → L. Corresponds to variant dbSNP:rs1078846Ensembl.1
Natural variantiVAR_055112284V → M5 PublicationsCorresponds to variant dbSNP:rs818818Ensembl.1
Natural variantiVAR_055113292S → G5 PublicationsCorresponds to variant dbSNP:rs818817Ensembl.1
Natural variantiVAR_055114466L → P. Corresponds to variant dbSNP:rs34256819Ensembl.1
Natural variantiVAR_055115512A → V. Corresponds to variant dbSNP:rs2070492Ensembl.1
Natural variantiVAR_055116560P → R2 PublicationsCorresponds to variant dbSNP:rs240033Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB011082 mRNA Translation: BAA76351.1
AB026898 Genomic DNA Translation: BAA77626.1
AK315317 mRNA Translation: BAG37720.1
AP006193 Genomic DNA No translation available.
CH471055 Genomic DNA Translation: EAW64529.1
BC075070 mRNA Translation: AAH75070.1
BC075071 mRNA Translation: AAH75071.1
BC126482 mRNA Translation: AAI26483.1
BC130543 mRNA Translation: AAI30544.1
CCDSiCCDS2677.1
RefSeqiNP_001306962.1, NM_001320033.1
NP_004794.2, NM_004803.4
XP_005265642.1, XM_005265585.4
XP_011532547.1, XM_011534245.2
UniGeneiHs.165559

Genome annotation databases

EnsembliENST00000273173; ENSP00000273173; ENSG00000144671
ENST00000448498; ENSP00000396283; ENSG00000144671
GeneIDi9389
KEGGihsa:9389
UCSCiuc003cib.3 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiS22AE_HUMAN
AccessioniPrimary (citable) accession number: Q9Y267
Secondary accession number(s): A0AVS9
, A1L4H6, B2RCX3, Q6DJT3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 4, 2006
Last sequence update: November 30, 2010
Last modified: June 20, 2018
This is version 125 of the entry and version 4 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

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