UniProtKB - Q9Y264 (ANGP4_HUMAN)
Protein
Angiopoietin-4
Gene
ANGPT4
Organism
Homo sapiens (Human)
Status
Functioni
Binds to TEK/TIE2, modulating ANGPT1 signaling. Can induce tyrosine phosphorylation of TEK/TIE2. Promotes endothelial cell survival, migration and angiogenesis.1 Publication
GO - Molecular functioni
- receptor tyrosine kinase binding Source: UniProtKB
- signaling receptor binding Source: GO_Central
- transmembrane receptor protein tyrosine kinase activator activity Source: UniProtKB
GO - Biological processi
- angiogenesis Source: GO_Central
- cellular response to hypoxia Source: UniProtKB
- leukocyte migration Source: Reactome
- negative regulation of angiogenesis Source: UniProtKB
- negative regulation of apoptotic process Source: UniProtKB
- negative regulation of blood vessel endothelial cell migration Source: UniProtKB
- Notch signaling pathway Source: Ensembl
- positive regulation of angiogenesis Source: UniProtKB
- positive regulation of blood vessel endothelial cell migration Source: UniProtKB
- positive regulation of endothelial cell migration Source: UniProtKB
- positive regulation of peptidyl-tyrosine phosphorylation Source: UniProtKB
- signal transduction Source: GO_Central
Keywordsi
Biological process | Angiogenesis |
Enzyme and pathway databases
PathwayCommonsi | Q9Y264 |
Reactomei | R-HSA-210993, Tie2 Signaling |
SignaLinki | Q9Y264 |
SIGNORi | Q9Y264 |
Names & Taxonomyi
Protein namesi | Recommended name: Angiopoietin-4Short name: ANG-4 Alternative name(s): Angiopoietin-3 Short name: ANG-3 |
Gene namesi | Name:ANGPT4 Synonyms:ANG3, ANG4 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:487, ANGPT4 |
MIMi | 603705, gene |
neXtProti | NX_Q9Y264 |
VEuPathDBi | HostDB:ENSG00000101280.7 |
Subcellular locationi
Extracellular region or secreted
- Secreted Curated
Extracellular region or secreted
- collagen-containing extracellular matrix Source: GO_Central
- extracellular region Source: Reactome
- extracellular space Source: UniProtKB
Keywords - Cellular componenti
SecretedPathology & Biotechi
Organism-specific databases
DisGeNETi | 51378 |
OpenTargetsi | ENSG00000101280 |
PharmGKBi | PA24793 |
Miscellaneous databases
Pharosi | Q9Y264, Tbio |
Genetic variation databases
BioMutai | ANGPT4 |
DMDMi | 17433288 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 24 | Sequence analysisAdd BLAST | 24 | |
ChainiPRO_0000009116 | 25 – 503 | Angiopoietin-4Add BLAST | 479 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Glycosylationi | 96 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 126 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 140 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 158 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 247 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 274 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Disulfide bondi | 291 ↔ 320 | PROSITE-ProRule annotation | ||
Glycosylationi | 311 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 337 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 427 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Disulfide bondi | 444 ↔ 457 | PROSITE-ProRule annotation |
Keywords - PTMi
Disulfide bond, GlycoproteinProteomic databases
EPDi | Q9Y264 |
PaxDbi | Q9Y264 |
PeptideAtlasi | Q9Y264 |
PRIDEi | Q9Y264 |
ProteomicsDBi | 5905 85668 [Q9Y264-1] |
PTM databases
GlyGeni | Q9Y264, 9 sites |
iPTMneti | Q9Y264 |
PhosphoSitePlusi | Q9Y264 |
Expressioni
Tissue specificityi
Highly expressed in the lung with much lower levels found in other tissues.
Gene expression databases
Bgeei | ENSG00000101280, Expressed in subcutaneous adipose tissue and 76 other tissues |
Genevisiblei | Q9Y264, HS |
Organism-specific databases
HPAi | ENSG00000101280, Tissue enhanced (adipose tissue, breast, cervix, uterine) |
Interactioni
Subunit structurei
Homodimer; disulfide-linked.
Interacts with TEK/TIE2.
1 PublicationGO - Molecular functioni
- receptor tyrosine kinase binding Source: UniProtKB
- signaling receptor binding Source: GO_Central
Protein-protein interaction databases
BioGRIDi | 119510, 4 interactors |
IntActi | Q9Y264, 2 interactors |
STRINGi | 9606.ENSP00000371347 |
Miscellaneous databases
RNActi | Q9Y264, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 282 – 502 | Fibrinogen C-terminalPROSITE-ProRule annotationAdd BLAST | 221 |
Coiled coil
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Coiled coili | 84 – 238 | Sequence analysisAdd BLAST | 155 |
Keywords - Domaini
Coiled coil, SignalPhylogenomic databases
eggNOGi | KOG2579, Eukaryota |
GeneTreei | ENSGT00940000160129 |
HOGENOMi | CLU_038628_3_1_1 |
InParanoidi | Q9Y264 |
OMAi | TRMMLRP |
OrthoDBi | 357340at2759 |
PhylomeDBi | Q9Y264 |
TreeFami | TF336658 |
Family and domain databases
CDDi | cd00087, FReD, 1 hit |
Gene3Di | 3.90.215.10, 1 hit 4.10.530.10, 1 hit |
InterProi | View protein in InterPro IPR028845, Ang-4 IPR036056, Fibrinogen-like_C IPR014716, Fibrinogen_a/b/g_C_1 IPR014715, Fibrinogen_a/b/g_C_2 IPR002181, Fibrinogen_a/b/g_C_dom IPR020837, Fibrinogen_CS |
PANTHERi | PTHR19143:SF31, PTHR19143:SF31, 1 hit |
Pfami | View protein in Pfam PF00147, Fibrinogen_C, 1 hit |
SMARTi | View protein in SMART SM00186, FBG, 1 hit |
SUPFAMi | SSF56496, SSF56496, 1 hit |
PROSITEi | View protein in PROSITE PS00514, FIBRINOGEN_C_1, 1 hit PS51406, FIBRINOGEN_C_2, 1 hit |
s (2)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basketIsoform 1 (identifier: Q9Y264-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MLSQLAMLQG SLLLVVATMS VAQQTRQEAD RGCETLVVQH GHCSYTFLLP
60 70 80 90 100
KSEPCPPGPE VSRDSNTLQR ESLANPLHLG KLPTQQVKQL EQALQNNTQW
110 120 130 140 150
LKKLERAIKT ILRSKLEQVQ QQMAQNQTAP MLELGTSLLN QTTAQIRKLT
160 170 180 190 200
DMEAQLLNQT SRMDAQMPET FLSTNKLENQ LLLQRQKLQQ LQGQNSALEK
210 220 230 240 250
RLQALETKQQ EELASILSKK AKLLNTLSRQ SAALTNIERG LRGVRHNSSL
260 270 280 290 300
LQDQQHSLRQ LLVLLRHLVQ ERANASAPAF IMAGEQVFQD CAEIQRSGAS
310 320 330 340 350
ASGVYTIQVS NATKPRKVFC DLQSSGGRWT LIQRRENGTV NFQRNWKDYK
360 370 380 390 400
QGFGDPAGEH WLGNEVVHQL TRRAAYSLRV ELQDWEGHEA YAQYEHFHLG
410 420 430 440 450
SENQLYRLSV VGYSGSAGRQ SSLVLQNTSF STLDSDNDHC LCKCAQVMSG
460 470 480 490 500
GWWFDACGLS NLNGVYYHAP DNKYKMDGIR WHYFKGPSYS LRASRMMIRP
LDI
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_049070 | 395 | E → K. Corresponds to variant dbSNP:rs869171Ensembl. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_055091 | 408 – 503 | LSVVG…RPLDI → VVV in isoform 2. 1 PublicationAdd BLAST | 96 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF074332 mRNA Translation: AAD31728.1 AF113708 mRNA Translation: AAD21587.1 AK304756 mRNA Translation: BAG65511.1 AL050325 Genomic DNA No translation available. AL161939 Genomic DNA No translation available. BC111976 mRNA Translation: AAI11977.1 BC111978 mRNA Translation: AAI11979.1 |
CCDSi | CCDS13009.1 [Q9Y264-1] |
RefSeqi | NP_001309738.1, NM_001322809.1 [Q9Y264-2] NP_057069.1, NM_015985.3 [Q9Y264-1] |
Genome annotation databases
Ensembli | ENST00000381922; ENSP00000371347; ENSG00000101280 [Q9Y264-1] |
GeneIDi | 51378 |
KEGGi | hsa:51378 |
UCSCi | uc002wei.4, human [Q9Y264-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF074332 mRNA Translation: AAD31728.1 AF113708 mRNA Translation: AAD21587.1 AK304756 mRNA Translation: BAG65511.1 AL050325 Genomic DNA No translation available. AL161939 Genomic DNA No translation available. BC111976 mRNA Translation: AAI11977.1 BC111978 mRNA Translation: AAI11979.1 |
CCDSi | CCDS13009.1 [Q9Y264-1] |
RefSeqi | NP_001309738.1, NM_001322809.1 [Q9Y264-2] NP_057069.1, NM_015985.3 [Q9Y264-1] |
3D structure databases
SMRi | Q9Y264 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 119510, 4 interactors |
IntActi | Q9Y264, 2 interactors |
STRINGi | 9606.ENSP00000371347 |
PTM databases
GlyGeni | Q9Y264, 9 sites |
iPTMneti | Q9Y264 |
PhosphoSitePlusi | Q9Y264 |
Genetic variation databases
BioMutai | ANGPT4 |
DMDMi | 17433288 |
Proteomic databases
EPDi | Q9Y264 |
PaxDbi | Q9Y264 |
PeptideAtlasi | Q9Y264 |
PRIDEi | Q9Y264 |
ProteomicsDBi | 5905 85668 [Q9Y264-1] |
Protocols and materials databases
ABCDi | Q9Y264, 10 sequenced antibodies |
Antibodypediai | 23019, 273 antibodies |
DNASUi | 51378 |
Genome annotation databases
Ensembli | ENST00000381922; ENSP00000371347; ENSG00000101280 [Q9Y264-1] |
GeneIDi | 51378 |
KEGGi | hsa:51378 |
UCSCi | uc002wei.4, human [Q9Y264-1] |
Organism-specific databases
CTDi | 51378 |
DisGeNETi | 51378 |
GeneCardsi | ANGPT4 |
HGNCi | HGNC:487, ANGPT4 |
HPAi | ENSG00000101280, Tissue enhanced (adipose tissue, breast, cervix, uterine) |
MIMi | 603705, gene |
neXtProti | NX_Q9Y264 |
OpenTargetsi | ENSG00000101280 |
PharmGKBi | PA24793 |
VEuPathDBi | HostDB:ENSG00000101280.7 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG2579, Eukaryota |
GeneTreei | ENSGT00940000160129 |
HOGENOMi | CLU_038628_3_1_1 |
InParanoidi | Q9Y264 |
OMAi | TRMMLRP |
OrthoDBi | 357340at2759 |
PhylomeDBi | Q9Y264 |
TreeFami | TF336658 |
Enzyme and pathway databases
PathwayCommonsi | Q9Y264 |
Reactomei | R-HSA-210993, Tie2 Signaling |
SignaLinki | Q9Y264 |
SIGNORi | Q9Y264 |
Miscellaneous databases
BioGRID-ORCSi | 51378, 4 hits in 870 CRISPR screens |
ChiTaRSi | ANGPT4, human |
GeneWikii | ANGPT4 |
GenomeRNAii | 51378 |
Pharosi | Q9Y264, Tbio |
PROi | PR:Q9Y264 |
RNActi | Q9Y264, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000101280, Expressed in subcutaneous adipose tissue and 76 other tissues |
Genevisiblei | Q9Y264, HS |
Family and domain databases
CDDi | cd00087, FReD, 1 hit |
Gene3Di | 3.90.215.10, 1 hit 4.10.530.10, 1 hit |
InterProi | View protein in InterPro IPR028845, Ang-4 IPR036056, Fibrinogen-like_C IPR014716, Fibrinogen_a/b/g_C_1 IPR014715, Fibrinogen_a/b/g_C_2 IPR002181, Fibrinogen_a/b/g_C_dom IPR020837, Fibrinogen_CS |
PANTHERi | PTHR19143:SF31, PTHR19143:SF31, 1 hit |
Pfami | View protein in Pfam PF00147, Fibrinogen_C, 1 hit |
SMARTi | View protein in SMART SM00186, FBG, 1 hit |
SUPFAMi | SSF56496, SSF56496, 1 hit |
PROSITEi | View protein in PROSITE PS00514, FIBRINOGEN_C_1, 1 hit PS51406, FIBRINOGEN_C_2, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | ANGP4_HUMAN | |
Accessioni | Q9Y264Primary (citable) accession number: Q9Y264 Secondary accession number(s): B4E3J9, Q5TFF4, Q9H4Z4 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | August 29, 2001 |
Last sequence update: | November 1, 1999 | |
Last modified: | February 10, 2021 | |
This is version 155 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human chromosome 20
Human chromosome 20: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot