UniProtKB - Q9Y263 (PLAP_HUMAN)
Phospholipase A-2-activating protein
PLAA
Functioni
Plays a role in protein ubiquitination, sorting and degradation through its association with VCP (PubMed:27753622).
Involved in ubiquitin-mediated membrane proteins trafficking to late endosomes in an ESCRT-dependent manner, and hence plays a role in synaptic vesicle recycling (By similarity).
May play a role in macroautophagy, regulating for instance the clearance of damaged lysosomes (PubMed:27753622).
Plays a role in cerebellar Purkinje cell development (By similarity).
Positively regulates cytosolic and calcium-independent phospholipase A2 activities in a tumor necrosis factor alpha (TNF-alpha)- or lipopolysaccharide (LPS)-dependent manner, and hence prostaglandin E2 biosynthesis (PubMed:18291623, PubMed:28007986).
By similarity3 PublicationsGO - Molecular functioni
- phospholipase A2 activator activity Source: ProtInc
- ubiquitin binding Source: GO_Central
GO - Biological processi
- cellular response to lipopolysaccharide Source: UniProtKB
- inflammatory response Source: Ensembl
- macroautophagy Source: UniProtKB
- negative regulation of protein K63-linked ubiquitination Source: UniProtKB
- nervous system development Source: UniProtKB-KW
- phospholipid metabolic process Source: ProtInc
- positive regulation of dendrite extension Source: UniProtKB
- positive regulation of neuron migration Source: UniProtKB
- positive regulation of phospholipase A2 activity Source: UniProtKB
- positive regulation of synaptic vesicle recycling Source: UniProtKB
- prostaglandin metabolic process Source: UniProtKB
- proteasome-mediated ubiquitin-dependent protein catabolic process Source: GO_Central
- signal transduction Source: ProtInc
- ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway Source: UniProtKB
- ubiquitin recycling Source: GO_Central
Keywordsi
Molecular function | Developmental protein |
Biological process | Neurogenesis |
Enzyme and pathway databases
PathwayCommonsi | Q9Y263 |
SignaLinki | Q9Y263 |
Names & Taxonomyi
Protein namesi | Recommended name: Phospholipase A-2-activating proteinShort name: PLA2P Short name: PLAP |
Gene namesi | Name:PLAA Synonyms:PLAP |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:9043, PLAA |
MIMi | 603873, gene |
neXtProti | NX_Q9Y263 |
VEuPathDBi | HostDB:ENSG00000137055 |
Subcellular locationi
Extracellular region or secreted
- extracellular exosome Source: UniProtKB
Nucleus
- nucleus Source: UniProtKB
Other locations
Keywords - Cellular componenti
Cell junction, Cytoplasm, Nucleus, SynapsePathology & Biotechi
Involvement in diseasei
Neurodevelopmental disorder with progressive microcephaly, spasticity, and brain anomalies (NDMSBA)2 Publications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_079276 | 23 | G → V in NDMSBA. 1 PublicationCorresponds to variant dbSNP:rs747956857EnsemblClinVar. | 1 | |
Natural variantiVAR_079277 | 752 | L → F in NDMSBA; no effect on protein stability; no effect on subcellular localization; decreased function in positive regulation of cytosolic phospholipase A2 activity; in patient cells homozygous for the mutation. 1 PublicationCorresponds to variant dbSNP:rs1114167457EnsemblClinVar. | 1 |
Keywords - Diseasei
Disease variant, Mental retardationOrganism-specific databases
DisGeNETi | 9373 |
MalaCardsi | PLAA |
MIMi | 617527, phenotype |
OpenTargetsi | ENSG00000137055 |
Orphaneti | 521426, PLAA-associated neurodevelopmental disorder |
PharmGKBi | PA33370 |
Miscellaneous databases
Pharosi | Q9Y263, Tchem |
Chemistry databases
ChEMBLi | CHEMBL6114 |
Genetic variation databases
BioMutai | PLAA |
DMDMi | 108935868 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000051130 | 1 – 795 | Phospholipase A-2-activating proteinAdd BLAST | 795 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 50 | PhosphoserineCombined sources | 1 | |
Modified residuei | 529 | N6-acetyllysineCombined sources | 1 |
Keywords - PTMi
Acetylation, PhosphoproteinProteomic databases
EPDi | Q9Y263 |
jPOSTi | Q9Y263 |
MassIVEi | Q9Y263 |
MaxQBi | Q9Y263 |
PaxDbi | Q9Y263 |
PeptideAtlasi | Q9Y263 |
PRIDEi | Q9Y263 |
ProteomicsDBi | 85667 |
PTM databases
GlyGeni | Q9Y263, 1 site, 1 O-linked glycan (1 site) |
iPTMneti | Q9Y263 |
MetOSitei | Q9Y263 |
PhosphoSitePlusi | Q9Y263 |
Expressioni
Inductioni
Gene expression databases
Bgeei | ENSG00000137055, Expressed in testis and 223 other tissues |
ExpressionAtlasi | Q9Y263, baseline and differential |
Genevisiblei | Q9Y263, HS |
Organism-specific databases
HPAi | ENSG00000137055, Low tissue specificity |
Interactioni
Subunit structurei
Binary interactionsi
Q9Y263
GO - Molecular functioni
- ubiquitin binding Source: GO_Central
Protein-protein interaction databases
BioGRIDi | 114774, 75 interactors |
IntActi | Q9Y263, 29 interactors |
MINTi | Q9Y263 |
STRINGi | 9606.ENSP00000380460 |
Chemistry databases
BindingDBi | Q9Y263 |
Miscellaneous databases
RNActi | Q9Y263, protein |
Structurei
Secondary structure
3D structure databases
AlphaFoldDBi | Q9Y263 |
BMRBi | Q9Y263 |
SMRi | Q9Y263 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | Q9Y263 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Repeati | 17 – 56 | WD 1Add BLAST | 40 | |
Repeati | 63 – 107 | WD 2Add BLAST | 45 | |
Repeati | 110 – 148 | WD 3Add BLAST | 39 | |
Repeati | 149 – 188 | WD 4Add BLAST | 40 | |
Repeati | 190 – 227 | WD 5Add BLAST | 38 | |
Repeati | 229 – 268 | WD 6Add BLAST | 40 | |
Repeati | 270 – 307 | WD 7Add BLAST | 38 | |
Domaini | 366 – 465 | PFUPROSITE-ProRule annotationAdd BLAST | 100 | |
Domaini | 533 – 794 | PULPROSITE-ProRule annotationAdd BLAST | 262 | |
Repeati | 546 – 588 | ARM 1Add BLAST | 43 | |
Repeati | 589 – 620 | ARM 2Add BLAST | 32 | |
Repeati | 621 – 669 | ARM 3Add BLAST | 49 | |
Repeati | 670 – 715 | ARM 4Add BLAST | 46 | |
Repeati | 716 – 755 | ARM 5Add BLAST | 40 | |
Repeati | 756 – 795 | ARM 6Add BLAST | 40 |
Domaini
Sequence similaritiesi
Keywords - Domaini
Repeat, WD repeatPhylogenomic databases
eggNOGi | KOG0301, Eukaryota |
GeneTreei | ENSGT00550000074944 |
HOGENOMi | CLU_011791_2_0_1 |
InParanoidi | Q9Y263 |
OMAi | HNVCALD |
OrthoDBi | 1274776at2759 |
PhylomeDBi | Q9Y263 |
TreeFami | TF105944 |
Family and domain databases
Gene3Di | 1.25.10.10, 1 hit 2.130.10.10, 1 hit 3.10.20.870, 1 hit |
IDEALi | IID00228 |
InterProi | View protein in InterPro IPR011989, ARM-like IPR016024, ARM-type_fold IPR015155, PFU IPR038122, PFU_sf IPR013535, PUL_dom IPR015943, WD40/YVTN_repeat-like_dom_sf IPR001680, WD40_repeat IPR036322, WD40_repeat_dom_sf |
Pfami | View protein in Pfam PF09070, PFU, 1 hit PF08324, PUL, 1 hit PF00400, WD40, 6 hits |
SMARTi | View protein in SMART SM00320, WD40, 7 hits |
SUPFAMi | SSF48371, SSF48371, 1 hit SSF50978, SSF50978, 1 hit |
PROSITEi | View protein in PROSITE PS51394, PFU, 1 hit PS51396, PUL, 1 hit PS50082, WD_REPEATS_2, 3 hits PS50294, WD_REPEATS_REGION, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 4 potential isoforms that are computationally mapped.Show allAlign All
10 20 30 40 50
MTSGATRYRL SCSLRGHELD VRGLVCCAYP PGAFVSVSRD RTTRLWAPDS
60 70 80 90 100
PNRSFTEMHC MSGHSNFVSC VCIIPSSDIY PHGLIATGGN DHNICIFSLD
110 120 130 140 150
SPMPLYILKG HKNTVCSLSS GKFGTLLSGS WDTTAKVWLN DKCMMTLQGH
160 170 180 190 200
TAAVWAVKIL PEQGLMLTGS ADKTVKLWKA GRCERTFSGH EDCVRGLAIL
210 220 230 240 250
SETEFLSCAN DASIRRWQIT GECLEVYYGH TNYIYSISVF PNCRDFVTTA
260 270 280 290 300
EDRSLRIWKH GECAQTIRLP AQSIWCCCVL DNGDIVVGAS DGIIRVFTES
310 320 330 340 350
EDRTASAEEI KAFEKELSHA TIDSKTGDLG DINAEQLPGR EHLNEPGTRE
360 370 380 390 400
GQTRLIRDGE KVEAYQWSVS EGRWIKIGDV VGSSGANQQT SGKVLYEGKE
410 420 430 440 450
FDYVFSIDVN EGGPSYKLPY NTSDDPWLTA YNFLQKNDLN PMFLDQVAKF
460 470 480 490 500
IIDNTKGQML GLGNPSFSDP FTGGGRYVPG SSGSSNTLPT ADPFTGAGRY
510 520 530 540 550
VPGSASMGTT MAGVDPFTGN SAYRSAASKT MNIYFPKKEA VTFDQANPTQ
560 570 580 590 600
ILGKLKELNG TAPEEKKLTE DDLILLEKIL SLICNSSSEK PTVQQLQILW
610 620 630 640 650
KAINCPEDIV FPALDILRLS IKHPSVNENF CNEKEGAQFS SHLINLLNPK
660 670 680 690 700
GKPANQLLAL RTFCNCFVGQ AGQKLMMSQR ESLMSHAIEL KSGSNKNIHI
710 720 730 740 750
ALATLALNYS VCFHKDHNIE GKAQCLSLIS TILEVVQDLE ATFRLLVALG
760 770 780 790
TLISDDSNAV QLAKSLGVDS QIKKYSSVSE PAKVSECCRF ILNLL
Computationally mapped potential isoform sequencesi
There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketE5RIM3 | E5RIM3_HUMAN | Phospholipase A-2-activating protei... | PLAA | 609 | Annotation score: | ||
H0YBW4 | H0YBW4_HUMAN | Phospholipase A-2-activating protei... | PLAA | 290 | Annotation score: | ||
H0YAU9 | H0YAU9_HUMAN | Phospholipase A-2-activating protei... | PLAA | 244 | Annotation score: | ||
H0YC16 | H0YC16_HUMAN | Phospholipase A-2-activating protei... | PLAA | 136 | Annotation score: |
Sequence cautioni
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 14 | L → F in AAD42075 (PubMed:10644453).Curated | 1 | |
Sequence conflicti | 57 | E → D in AAD42075 (PubMed:10644453).Curated | 1 | |
Sequence conflicti | 86 | A → F in AAD42075 (PubMed:10644453).Curated | 1 | |
Sequence conflicti | 97 | F → L in AAD42075 (PubMed:10644453).Curated | 1 | |
Sequence conflicti | 172 | D → G in BAA91803 (PubMed:14702039).Curated | 1 | |
Sequence conflicti | 363 | E → K in BAD97264 (Ref. 6) Curated | 1 | |
Sequence conflicti | 422 | T → A in AAD42075 (PubMed:10644453).Curated | 1 | |
Sequence conflicti | 520 | N → S in BAA92105 (PubMed:14702039).Curated | 1 | |
Sequence conflicti | 531 | M → L in AAD42075 (PubMed:10644453).Curated | 1 | |
Sequence conflicti | 541 | V → L in AAD42075 (PubMed:10644453).Curated | 1 | |
Sequence conflicti | 746 | L → P in AAD42075 (PubMed:10644453).Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_079276 | 23 | G → V in NDMSBA. 1 PublicationCorresponds to variant dbSNP:rs747956857EnsemblClinVar. | 1 | |
Natural variantiVAR_079277 | 752 | L → F in NDMSBA; no effect on protein stability; no effect on subcellular localization; decreased function in positive regulation of cytosolic phospholipase A2 activity; in patient cells homozygous for the mutation. 1 PublicationCorresponds to variant dbSNP:rs1114167457EnsemblClinVar. | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK001642 mRNA Translation: BAA91803.1 AK002143 mRNA Translation: BAA92105.1 Sequence problems. AL133608 mRNA Translation: CAB63739.1 AL356133 Genomic DNA No translation available. BC032551 mRNA Translation: AAH32551.1 AF145020 mRNA Translation: AAD42075.1 Sequence problems. AK223544 mRNA Translation: BAD97264.1 Different initiation. AJ238243 mRNA Translation: CAB42881.1 Different initiation. AF083395 mRNA Translation: AAD03030.1 Different initiation. |
CCDSi | CCDS35000.1 |
PIRi | T43447 |
RefSeqi | NP_001026859.1, NM_001031689.2 |
Genome annotation databases
Ensembli | ENST00000397292.8; ENSP00000380460.3; ENSG00000137055.15 |
GeneIDi | 9373 |
KEGGi | hsa:9373 |
MANE-Selecti | ENST00000397292.8; ENSP00000380460.3; NM_001031689.3; NP_001026859.1 |
UCSCi | uc003zqd.4, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK001642 mRNA Translation: BAA91803.1 AK002143 mRNA Translation: BAA92105.1 Sequence problems. AL133608 mRNA Translation: CAB63739.1 AL356133 Genomic DNA No translation available. BC032551 mRNA Translation: AAH32551.1 AF145020 mRNA Translation: AAD42075.1 Sequence problems. AK223544 mRNA Translation: BAD97264.1 Different initiation. AJ238243 mRNA Translation: CAB42881.1 Different initiation. AF083395 mRNA Translation: AAD03030.1 Different initiation. |
CCDSi | CCDS35000.1 |
PIRi | T43447 |
RefSeqi | NP_001026859.1, NM_001031689.2 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
2K89 | NMR | - | A | 386-465 | [»] | |
2K8A | NMR | - | A | 386-465 | [»] | |
2K8B | NMR | - | B | 386-465 | [»] | |
2K8C | NMR | - | B | 386-465 | [»] | |
3EBB | X-ray | 1.90 | A/B/C/D | 511-795 | [»] | |
AlphaFoldDBi | Q9Y263 | |||||
BMRBi | Q9Y263 | |||||
SMRi | Q9Y263 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 114774, 75 interactors |
IntActi | Q9Y263, 29 interactors |
MINTi | Q9Y263 |
STRINGi | 9606.ENSP00000380460 |
Chemistry databases
BindingDBi | Q9Y263 |
ChEMBLi | CHEMBL6114 |
PTM databases
GlyGeni | Q9Y263, 1 site, 1 O-linked glycan (1 site) |
iPTMneti | Q9Y263 |
MetOSitei | Q9Y263 |
PhosphoSitePlusi | Q9Y263 |
Genetic variation databases
BioMutai | PLAA |
DMDMi | 108935868 |
Proteomic databases
EPDi | Q9Y263 |
jPOSTi | Q9Y263 |
MassIVEi | Q9Y263 |
MaxQBi | Q9Y263 |
PaxDbi | Q9Y263 |
PeptideAtlasi | Q9Y263 |
PRIDEi | Q9Y263 |
ProteomicsDBi | 85667 |
Protocols and materials databases
Antibodypediai | 3560, 426 antibodies from 29 providers |
DNASUi | 9373 |
Genome annotation databases
Ensembli | ENST00000397292.8; ENSP00000380460.3; ENSG00000137055.15 |
GeneIDi | 9373 |
KEGGi | hsa:9373 |
MANE-Selecti | ENST00000397292.8; ENSP00000380460.3; NM_001031689.3; NP_001026859.1 |
UCSCi | uc003zqd.4, human |
Organism-specific databases
CTDi | 9373 |
DisGeNETi | 9373 |
GeneCardsi | PLAA |
HGNCi | HGNC:9043, PLAA |
HPAi | ENSG00000137055, Low tissue specificity |
MalaCardsi | PLAA |
MIMi | 603873, gene 617527, phenotype |
neXtProti | NX_Q9Y263 |
OpenTargetsi | ENSG00000137055 |
Orphaneti | 521426, PLAA-associated neurodevelopmental disorder |
PharmGKBi | PA33370 |
VEuPathDBi | HostDB:ENSG00000137055 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG0301, Eukaryota |
GeneTreei | ENSGT00550000074944 |
HOGENOMi | CLU_011791_2_0_1 |
InParanoidi | Q9Y263 |
OMAi | HNVCALD |
OrthoDBi | 1274776at2759 |
PhylomeDBi | Q9Y263 |
TreeFami | TF105944 |
Enzyme and pathway databases
PathwayCommonsi | Q9Y263 |
SignaLinki | Q9Y263 |
Miscellaneous databases
BioGRID-ORCSi | 9373, 21 hits in 1075 CRISPR screens |
ChiTaRSi | PLAA, human |
EvolutionaryTracei | Q9Y263 |
GeneWikii | PLAA_(gene) |
GenomeRNAii | 9373 |
Pharosi | Q9Y263, Tchem |
PROi | PR:Q9Y263 |
RNActi | Q9Y263, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000137055, Expressed in testis and 223 other tissues |
ExpressionAtlasi | Q9Y263, baseline and differential |
Genevisiblei | Q9Y263, HS |
Family and domain databases
Gene3Di | 1.25.10.10, 1 hit 2.130.10.10, 1 hit 3.10.20.870, 1 hit |
IDEALi | IID00228 |
InterProi | View protein in InterPro IPR011989, ARM-like IPR016024, ARM-type_fold IPR015155, PFU IPR038122, PFU_sf IPR013535, PUL_dom IPR015943, WD40/YVTN_repeat-like_dom_sf IPR001680, WD40_repeat IPR036322, WD40_repeat_dom_sf |
Pfami | View protein in Pfam PF09070, PFU, 1 hit PF08324, PUL, 1 hit PF00400, WD40, 6 hits |
SMARTi | View protein in SMART SM00320, WD40, 7 hits |
SUPFAMi | SSF48371, SSF48371, 1 hit SSF50978, SSF50978, 1 hit |
PROSITEi | View protein in PROSITE PS51394, PFU, 1 hit PS51396, PUL, 1 hit PS50082, WD_REPEATS_2, 3 hits PS50294, WD_REPEATS_REGION, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | PLAP_HUMAN | |
Accessioni | Q9Y263Primary (citable) accession number: Q9Y263 Secondary accession number(s): Q53EU5 Q9Y5L1 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | January 11, 2001 |
Last sequence update: | June 13, 2006 | |
Last modified: | May 25, 2022 | |
This is version 190 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- Human chromosome 9
Human chromosome 9: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families