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UniProtKB - Q9Y263 (PLAP_HUMAN)

Entry version 190 (25 May 2022)
Sequence version 2 (13 Jun 2006)
Previous versions | rss
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Protein

Phospholipase A-2-activating protein

Gene

PLAA

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Plays a role in protein ubiquitination, sorting and degradation through its association with VCP (PubMed:27753622).

Involved in ubiquitin-mediated membrane proteins trafficking to late endosomes in an ESCRT-dependent manner, and hence plays a role in synaptic vesicle recycling (By similarity).

May play a role in macroautophagy, regulating for instance the clearance of damaged lysosomes (PubMed:27753622).

Plays a role in cerebellar Purkinje cell development (By similarity).

Positively regulates cytosolic and calcium-independent phospholipase A2 activities in a tumor necrosis factor alpha (TNF-alpha)- or lipopolysaccharide (LPS)-dependent manner, and hence prostaglandin E2 biosynthesis (PubMed:18291623, PubMed:28007986).

By similarity3 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDevelopmental protein
Biological processNeurogenesis

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		Q9Y263

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...SignaLinki		Q9Y263

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Phospholipase A-2-activating protein
Short name:
PLA2P
Short name:
PLAP
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:PLAA
Synonyms:PLAP
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 9

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:9043, PLAA

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		603873, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_Q9Y263

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSG00000137055

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Cell junction, Cytoplasm, Nucleus, Synapse

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the 'Pathology and Biotech' section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Neurodevelopmental disorder with progressive microcephaly, spasticity, and brain anomalies (NDMSBA)2 Publications
The disease is caused by variants affecting the gene represented in this entry.
Disease descriptionAn autosomal recessive neurodevelopmental disorder characterized by progressive microcephaly, spastic quadriparesis, global developmental delay, profound mental retardation and severely impaired or absent motor function. More variable features include seizures and optic atrophy.
Related information in OMIM
Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_07927623G → V in NDMSBA. 1 PublicationCorresponds to variant dbSNP:rs747956857EnsemblClinVar.1
Natural variantiVAR_079277752L → F in NDMSBA; no effect on protein stability; no effect on subcellular localization; decreased function in positive regulation of cytosolic phospholipase A2 activity; in patient cells homozygous for the mutation. 1 PublicationCorresponds to variant dbSNP:rs1114167457EnsemblClinVar.1

Keywords - Diseasei

Disease variant, Mental retardation

Organism-specific databases

DisGeNET

More...DisGeNETi		9373

MalaCards human disease database

More...MalaCardsi		PLAA
MIMi617527, phenotype

Open Targets

More...OpenTargetsi		ENSG00000137055

Orphanet; a database dedicated to information on rare diseases and orphan drugs

More...Orphaneti		521426, PLAA-associated neurodevelopmental disorder

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA33370

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		Q9Y263, Tchem

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...ChEMBLi		CHEMBL6114

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		PLAA

Domain mapping of disease mutations (DMDM)

More...DMDMi		108935868

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000511301 – 795Phospholipase A-2-activating proteinAdd BLAST795

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei50PhosphoserineCombined sources1
Modified residuei529N6-acetyllysineCombined sources1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		Q9Y263

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		Q9Y263

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		Q9Y263

MaxQB - The MaxQuant DataBase

More...MaxQBi		Q9Y263

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q9Y263

PeptideAtlas

More...PeptideAtlasi		Q9Y263

PRoteomics IDEntifications database

More...PRIDEi		Q9Y263

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		85667

PTM databases

GlyGen: Computational and Informatics Resources for Glycoscience

More...GlyGeni		Q9Y263, 1 site, 1 O-linked glycan (1 site)

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q9Y263

MetOSite database of methionine sulfoxide sites

More...MetOSitei		Q9Y263

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q9Y263

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section reports the experimentally proven effects of inducers and repressors (usually chemical compounds or environmental factors) on the level of protein (or mRNA) expression (up-regulation, down-regulation, constitutive expression).<p><a href='/help/induction' target='_top'>More...</a></p>Inductioni

Up-regulated by tumor necrosis factor alpha (TNF-alpha) (at protein level) (PubMed:18291623).1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000137055, Expressed in testis and 223 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		Q9Y263, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q9Y263, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000137055, Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with ubiquitin (PubMed:19423704).

Interacts with UBXN6, VCP and YOD1; may form a complex involved in macroautophagy (PubMed:27753622, PubMed:19887378).

3 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details

GO - Molecular functioni

Complete GO annotation on QuickGO ...

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		114774, 75 interactors

Protein interaction database and analysis system

More...IntActi		Q9Y263, 29 interactors

Molecular INTeraction database

More...MINTi		Q9Y263

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000380460

Chemistry databases

BindingDB database of measured binding affinities

More...BindingDBi		Q9Y263

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		Q9Y263, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1795
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

AlphaFold Protein Structure Database

More...AlphaFoldDBi		Q9Y263

Biological Magnetic Resonance Data Bank

More...BMRBi		Q9Y263

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q9Y263

Database of comparative protein structure models

More...ModBasei		Search...

Protein Data Bank in Europe - Knowledge Base

More...PDBe-KBi		Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...EvolutionaryTracei		Q9Y263

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati17 – 56WD 1Add BLAST40
Repeati63 – 107WD 2Add BLAST45
Repeati110 – 148WD 3Add BLAST39
Repeati149 – 188WD 4Add BLAST40
Repeati190 – 227WD 5Add BLAST38
Repeati229 – 268WD 6Add BLAST40
Repeati270 – 307WD 7Add BLAST38
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini366 – 465PFUPROSITE-ProRule annotationAdd BLAST100
Domaini533 – 794PULPROSITE-ProRule annotationAdd BLAST262
Repeati546 – 588ARM 1Add BLAST43
Repeati589 – 620ARM 2Add BLAST32
Repeati621 – 669ARM 3Add BLAST49
Repeati670 – 715ARM 4Add BLAST46
Repeati716 – 755ARM 5Add BLAST40
Repeati756 – 795ARM 6Add BLAST40

<p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The PUL domain is composed of 6 armadillo-like repeats and mediates the interaction with VCP C-terminus.1 Publication
The PFU domain mediates interaction with ubiquitin.1 Publication

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the WD repeat PLAP family.Curated

Keywords - Domaini

Repeat, WD repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG0301, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00550000074944

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_011791_2_0_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q9Y263

Identification of Orthologs from Complete Genome Data

More...OMAi		HNVCALD

Database of Orthologous Groups

More...OrthoDBi		1274776at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q9Y263

TreeFam database of animal gene trees

More...TreeFami		TF105944

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		1.25.10.10, 1 hit
2.130.10.10, 1 hit
3.10.20.870, 1 hit

Intrinsically Disordered proteins with Extensive Annotations and Literature

More...IDEALi		IID00228

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR011989, ARM-like
IPR016024, ARM-type_fold
IPR015155, PFU
IPR038122, PFU_sf
IPR013535, PUL_dom
IPR015943, WD40/YVTN_repeat-like_dom_sf
IPR001680, WD40_repeat
IPR036322, WD40_repeat_dom_sf

Pfam protein domain database

More...Pfami		View protein in Pfam
PF09070, PFU, 1 hit
PF08324, PUL, 1 hit
PF00400, WD40, 6 hits

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00320, WD40, 7 hits

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF48371, SSF48371, 1 hit
SSF50978, SSF50978, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS51394, PFU, 1 hit
PS51396, PUL, 1 hit
PS50082, WD_REPEATS_2, 3 hits
PS50294, WD_REPEATS_REGION, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 4 potential isoforms that are computationally mapped.Show allAlign All

Q9Y263-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MTSGATRYRL SCSLRGHELD VRGLVCCAYP PGAFVSVSRD RTTRLWAPDS 
        60         70         80         90        100
PNRSFTEMHC MSGHSNFVSC VCIIPSSDIY PHGLIATGGN DHNICIFSLD 
       110        120        130        140        150
SPMPLYILKG HKNTVCSLSS GKFGTLLSGS WDTTAKVWLN DKCMMTLQGH 
       160        170        180        190        200
TAAVWAVKIL PEQGLMLTGS ADKTVKLWKA GRCERTFSGH EDCVRGLAIL 
       210        220        230        240        250
SETEFLSCAN DASIRRWQIT GECLEVYYGH TNYIYSISVF PNCRDFVTTA 
       260        270        280        290        300
EDRSLRIWKH GECAQTIRLP AQSIWCCCVL DNGDIVVGAS DGIIRVFTES 
       310        320        330        340        350
EDRTASAEEI KAFEKELSHA TIDSKTGDLG DINAEQLPGR EHLNEPGTRE 
       360        370        380        390        400
GQTRLIRDGE KVEAYQWSVS EGRWIKIGDV VGSSGANQQT SGKVLYEGKE 
       410        420        430        440        450
FDYVFSIDVN EGGPSYKLPY NTSDDPWLTA YNFLQKNDLN PMFLDQVAKF 
       460        470        480        490        500
IIDNTKGQML GLGNPSFSDP FTGGGRYVPG SSGSSNTLPT ADPFTGAGRY 
       510        520        530        540        550
VPGSASMGTT MAGVDPFTGN SAYRSAASKT MNIYFPKKEA VTFDQANPTQ 
       560        570        580        590        600
ILGKLKELNG TAPEEKKLTE DDLILLEKIL SLICNSSSEK PTVQQLQILW 
       610        620        630        640        650
KAINCPEDIV FPALDILRLS IKHPSVNENF CNEKEGAQFS SHLINLLNPK 
       660        670        680        690        700
GKPANQLLAL RTFCNCFVGQ AGQKLMMSQR ESLMSHAIEL KSGSNKNIHI 
       710        720        730        740        750
ALATLALNYS VCFHKDHNIE GKAQCLSLIS TILEVVQDLE ATFRLLVALG 
       760        770        780        790 
TLISDDSNAV QLAKSLGVDS QIKKYSSVSE PAKVSECCRF ILNLL
Length:795
Mass (Da):87,157
Last modified:June 13, 2006 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iD6E7330AC9891637
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E5RIM3E5RIM3_HUMAN
Phospholipase A-2-activating protei...
PLAA
609Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0YBW4H0YBW4_HUMAN
Phospholipase A-2-activating protei...
PLAA
290Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0YAU9H0YAU9_HUMAN
Phospholipase A-2-activating protei...
PLAA
244Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0YC16H0YC16_HUMAN
Phospholipase A-2-activating protei...
PLAA
136Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAD03030 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated
The sequence AAD42075 differs from that shown. Reason: Frameshift.Curated
The sequence AAD42075 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated
The sequence BAA92105 differs from that shown. Reason: Erroneous termination. Truncated C-terminus.Curated
The sequence BAD97264 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated
The sequence CAB42881 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti14L → F in AAD42075 (PubMed:10644453).Curated1
Sequence conflicti57E → D in AAD42075 (PubMed:10644453).Curated1
Sequence conflicti86A → F in AAD42075 (PubMed:10644453).Curated1
Sequence conflicti97F → L in AAD42075 (PubMed:10644453).Curated1
Sequence conflicti172D → G in BAA91803 (PubMed:14702039).Curated1
Sequence conflicti363E → K in BAD97264 (Ref. 6) Curated1
Sequence conflicti422T → A in AAD42075 (PubMed:10644453).Curated1
Sequence conflicti520N → S in BAA92105 (PubMed:14702039).Curated1
Sequence conflicti531M → L in AAD42075 (PubMed:10644453).Curated1
Sequence conflicti541V → L in AAD42075 (PubMed:10644453).Curated1
Sequence conflicti746L → P in AAD42075 (PubMed:10644453).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_07927623G → V in NDMSBA. 1 PublicationCorresponds to variant dbSNP:rs747956857EnsemblClinVar.1
Natural variantiVAR_079277752L → F in NDMSBA; no effect on protein stability; no effect on subcellular localization; decreased function in positive regulation of cytosolic phospholipase A2 activity; in patient cells homozygous for the mutation. 1 PublicationCorresponds to variant dbSNP:rs1114167457EnsemblClinVar.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AK001642 mRNA Translation: BAA91803.1
AK002143 mRNA Translation: BAA92105.1 Sequence problems.
AL133608 mRNA Translation: CAB63739.1
AL356133 Genomic DNA No translation available.
BC032551 mRNA Translation: AAH32551.1
AF145020 mRNA Translation: AAD42075.1 Sequence problems.
AK223544 mRNA Translation: BAD97264.1 Different initiation.
AJ238243 mRNA Translation: CAB42881.1 Different initiation.
AF083395 mRNA Translation: AAD03030.1 Different initiation.

The Consensus CDS (CCDS) project

More...CCDSi		CCDS35000.1

Protein sequence database of the Protein Information Resource

More...PIRi		T43447

NCBI Reference Sequences

More...RefSeqi		NP_001026859.1, NM_001031689.2

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000397292.8; ENSP00000380460.3; ENSG00000137055.15

Database of genes from NCBI RefSeq genomes

More...GeneIDi		9373

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:9373

Matched Annotation from NCBI and EMBL-EBI (MANE) - Phase one

More...MANE-Selecti		ENST00000397292.8; ENSP00000380460.3; NM_001031689.3; NP_001026859.1

UCSC genome browser

More...UCSCi		uc003zqd.4, human

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK001642 mRNA Translation: BAA91803.1
AK002143 mRNA Translation: BAA92105.1 Sequence problems.
AL133608 mRNA Translation: CAB63739.1
AL356133 Genomic DNA No translation available.
BC032551 mRNA Translation: AAH32551.1
AF145020 mRNA Translation: AAD42075.1 Sequence problems.
AK223544 mRNA Translation: BAD97264.1 Different initiation.
AJ238243 mRNA Translation: CAB42881.1 Different initiation.
AF083395 mRNA Translation: AAD03030.1 Different initiation.
CCDSiCCDS35000.1
PIRiT43447
RefSeqiNP_001026859.1, NM_001031689.2

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...PDBei

Protein Data Bank RCSB

More...RCSB PDBi

Protein Data Bank Japan

More...PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2K89NMR-A386-465[»]
2K8ANMR-A386-465[»]
2K8BNMR-B386-465[»]
2K8CNMR-B386-465[»]
3EBBX-ray1.90A/B/C/D511-795[»]
AlphaFoldDBiQ9Y263
BMRBiQ9Y263
SMRiQ9Y263
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi114774, 75 interactors
IntActiQ9Y263, 29 interactors
MINTiQ9Y263
STRINGi9606.ENSP00000380460

Chemistry databases

BindingDBiQ9Y263
ChEMBLiCHEMBL6114

PTM databases

GlyGeniQ9Y263, 1 site, 1 O-linked glycan (1 site)
iPTMnetiQ9Y263
MetOSiteiQ9Y263
PhosphoSitePlusiQ9Y263

Genetic variation databases

BioMutaiPLAA
DMDMi108935868

Proteomic databases

EPDiQ9Y263
jPOSTiQ9Y263
MassIVEiQ9Y263
MaxQBiQ9Y263
PaxDbiQ9Y263
PeptideAtlasiQ9Y263
PRIDEiQ9Y263
ProteomicsDBi85667

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		3560, 426 antibodies from 29 providers

The DNASU plasmid repository

More...DNASUi		9373

Genome annotation databases

EnsembliENST00000397292.8; ENSP00000380460.3; ENSG00000137055.15
GeneIDi9373
KEGGihsa:9373
MANE-SelectiENST00000397292.8; ENSP00000380460.3; NM_001031689.3; NP_001026859.1
UCSCiuc003zqd.4, human

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		9373
DisGeNETi9373

GeneCards: human genes, protein and diseases

More...GeneCardsi		PLAA
HGNCiHGNC:9043, PLAA
HPAiENSG00000137055, Low tissue specificity
MalaCardsiPLAA
MIMi603873, gene
617527, phenotype
neXtProtiNX_Q9Y263
OpenTargetsiENSG00000137055
Orphaneti521426, PLAA-associated neurodevelopmental disorder
PharmGKBiPA33370
VEuPathDBiHostDB:ENSG00000137055

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG0301, Eukaryota
GeneTreeiENSGT00550000074944
HOGENOMiCLU_011791_2_0_1
InParanoidiQ9Y263
OMAiHNVCALD
OrthoDBi1274776at2759
PhylomeDBiQ9Y263
TreeFamiTF105944

Enzyme and pathway databases

PathwayCommonsiQ9Y263
SignaLinkiQ9Y263

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		9373, 21 hits in 1075 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		PLAA, human
EvolutionaryTraceiQ9Y263

The Gene Wiki collection of pages on human genes and proteins

More...GeneWikii		PLAA_(gene)

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		9373
PharosiQ9Y263, Tchem

Protein Ontology

More...PROi		PR:Q9Y263
RNActiQ9Y263, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000137055, Expressed in testis and 223 other tissues
ExpressionAtlasiQ9Y263, baseline and differential
GenevisibleiQ9Y263, HS

Family and domain databases

Gene3Di1.25.10.10, 1 hit
2.130.10.10, 1 hit
3.10.20.870, 1 hit
IDEALiIID00228
InterProiView protein in InterPro
IPR011989, ARM-like
IPR016024, ARM-type_fold
IPR015155, PFU
IPR038122, PFU_sf
IPR013535, PUL_dom
IPR015943, WD40/YVTN_repeat-like_dom_sf
IPR001680, WD40_repeat
IPR036322, WD40_repeat_dom_sf
PfamiView protein in Pfam
PF09070, PFU, 1 hit
PF08324, PUL, 1 hit
PF00400, WD40, 6 hits
SMARTiView protein in SMART
SM00320, WD40, 7 hits
SUPFAMiSSF48371, SSF48371, 1 hit
SSF50978, SSF50978, 1 hit
PROSITEiView protein in PROSITE
PS51394, PFU, 1 hit
PS51396, PUL, 1 hit
PS50082, WD_REPEATS_2, 3 hits
PS50294, WD_REPEATS_REGION, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiPLAP_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9Y263
Secondary accession number(s): Q53EU5
, Q5VY33, Q9NUL8, Q9NVE9, Q9UF53, Q9Y5L1
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 11, 2001
Last sequence update: June 13, 2006
Last modified: May 25, 2022
This is version 190 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Reference proteome

Documents

  1. Human chromosome 9
    Human chromosome 9: entries, gene names and cross-references to MIM
  2. Human entries with genetic variants
    List of human entries with genetic variants
  3. Human variants curated from literature reports
    Index of human variants curated from literature reports
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families
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