FOXA2

Functionⁱ

Transcription factor that is involved in embryonic development, establishment of tissue-specific gene expression and regulation of gene expression in differentiated tissues. Is thought to act as a 'pioneer' factor opening the compacted chromatin for other proteins through interactions with nucleosomal core histones and thereby replacing linker histones at target enhancer and/or promoter sites. Binds DNA with the consensus sequence 5'-[AC]A[AT]T[AG]TT[GT][AG][CT]T[CT]-3' (By similarity). In embryonic development is required for notochord formation. Involved in the development of multiple endoderm-derived organ systems such as the liver, pancreas and lungs; FOXA1 and FOXA2 seem to have at least in part redundant roles. Originally described as a transcription activator for a number of liver genes such as AFP, albumin, tyrosine aminotransferase, PEPCK, etc. Interacts with the cis-acting regulatory regions of these genes. Involved in glucose homeostasis; regulates the expression of genes important for glucose sensing in pancreatic beta-cells and glucose homeostasis. Involved in regulation of fat metabolism. Binds to fibrinogen beta promoter and is involved in IL6-induced fibrinogen beta transcriptional activation.By similarity

Regions

Feature key	Position(s)	DescriptionActions	Graphical view	Length
DNA bindingⁱ	159 – 252	Fork-headPROSITE-ProRule annotationAdd BLAST		94

GO - Molecular functionⁱ

DNA binding
Source: UniProtKB
Inferred from direct assayⁱ
- 9931457
DNA-binding transcription factor activity
Source: UniProtKB
Inferred from direct assayⁱ
- 9931457
protein domain specific binding Source: InterPro
RNA polymerase II proximal promoter sequence-specific DNA binding
Source: BHF-UCL
Inferred from direct assayⁱ
- 12642491
RNA polymerase II transcription factor activity, sequence-specific DNA binding Source: NTNU_SB
transcription factor binding Source: InterPro
transcription regulatory region DNA binding
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 15737987

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

adult locomotory behavior Source: ParkinsonsUK-UCL
anatomical structure morphogenesis Source: GO_Central
cell fate specification Source: ParkinsonsUK-UCL
chromatin organization Source: UniProtKB-KW
dopaminergic neuron differentiation
Source: ParkinsonsUK-UCL
Inferred from genetic interactionⁱ
- 19951692
endocrine pancreas development
Source: BHF-UCL
Inferred from direct assayⁱ
- 12124776
negative regulation of detection of glucose Source: BHF-UCL
negative regulation of DNA-binding transcription factor activity
Source: BHF-UCL
Inferred from mutant phenotypeⁱ
- 12642491
negative regulation of epithelial to mesenchymal transition
Source: BHF-UCL
Inferred from mutant phenotypeⁱ
- 20160041
negative regulation of glucokinase activity Source: BHF-UCL
negative regulation of transcription from RNA polymerase II promoter by glucose Source: BHF-UCL
positive regulation of cell-cell adhesion mediated by cadherin
Source: BHF-UCL
Inferred by curatorⁱ
- 20160041
positive regulation of embryonic development Source: UniProtKB
positive regulation of gastrulation Source: UniProtKB
positive regulation of transcription, DNA-templated
Source: UniProtKB
Inferred from direct assayⁱ
- 9931457
positive regulation of transcription by RNA polymerase II
Source: BHF-UCL
Inferred from direct assayⁱ
- 12124776
- 20160041
positive regulation of transcription from RNA polymerase II promoter by glucose Source: BHF-UCL
primitive streak formation Source: UniProtKB
regulation of blood coagulation
Source: UniProtKB
Inferred from direct assayⁱ
- 12911579
regulation of insulin secretion involved in cellular response to glucose stimulus Source: BHF-UCL
regulation of transcription by RNA polymerase II
Source: BHF-UCL
Inferred from direct assayⁱ
- 12911579
response to interleukin-6
Source: UniProtKB
Traceable author statementⁱ
- 15737987
transcription, DNA-templated Source: UniProtKB-KW

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Activator, Chromatin regulator, Developmental protein, DNA-binding
Biological process	Transcription, Transcription regulation

Enzyme and pathway databases

Reactomeⁱ	R-HSA-210745 Regulation of gene expression in beta cells
SignaLinkⁱ	Q9Y261
SIGNORⁱ	Q9Y261

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Hepatocyte nuclear factor 3-beta Short name: HNF-3-beta Short name: HNF-3B Alternative name(s): Forkhead box protein A2 Transcription factor 3B Short name: TCF-3B
Gene namesⁱ	Name:FOXA2 Synonyms:HNF3B, TCF3B
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 20

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000125798.14
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:5022 FOXA2
MIMⁱ	600288 gene
neXtProtⁱ	NX_Q9Y261

Keywords - Cellular componentⁱ

Cytoplasm, Nucleus

Pathology & Biotechⁱ

Organism-specific databases

DisGeNET More...DisGeNETⁱ	3170
Open Targets More...OpenTargetsⁱ	ENSG00000125798
PharmGKBⁱ	PA201091

Polymorphism and mutation databases

BioMutaⁱ	FOXA2
DMDMⁱ	8134491

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000091795	1 – 457	Hepatocyte nuclear factor 3-betaAdd BLAST		457

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Modified residueⁱ	156	PhosphothreonineBy similarity	1
Modified residueⁱ	212	PhosphoserineBy similarity	1
Modified residueⁱ	283	PhosphoserineBy similarity	1
Modified residueⁱ	301	PhosphothreonineBy similarity	1
Modified residueⁱ	303	PhosphoserineCombined sources	1
Modified residueⁱ	306	PhosphoserineBy similarity	1
Modified residueⁱ	307	PhosphoserineBy similarity	1
Modified residueⁱ	309	PhosphoserineCombined sources	1
Modified residueⁱ	436	PhosphoserineBy similarity	1
Modified residueⁱ	457	PhosphoserineBy similarity	1

Post-translational modificationⁱ

Phosphorylation on Thr-156 abolishes binding to target promoters and subsequent transcription activation upon insulin stimulation.By similarity

Keywords - PTMⁱ

Phosphoprotein

Proteomic databases

PaxDbⁱ	Q9Y261
PeptideAtlas More...PeptideAtlasⁱ	Q9Y261
PRIDEⁱ	Q9Y261
ProteomicsDBⁱ	85664 85665 [Q9Y261-2]

PTM databases

iPTMnetⁱ	Q9Y261
PhosphoSitePlusⁱ	Q9Y261

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSG00000125798 Expressed in 72 organ(s), highest expression level in endometrium
CleanExⁱ	HS_FOXA2
ExpressionAtlasⁱ	Q9Y261 baseline and differential
Genevisibleⁱ	Q9Y261 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	CAB001388 HPA066846

HPAⁱ

CAB001388
HPA066846

Interactionⁱ

Subunit structureⁱ

Binds DNA as a monomer. Binds TLE1 (By similarity). Interacts with FOXA1 and FOXA3. Interacts with PRKDC.By similarity2 Publications

GO - Molecular functionⁱ

protein domain specific binding Source: InterPro
transcription factor binding Source: InterPro

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGridⁱ	109412, 18 interactors
IntActⁱ	Q9Y261, 10 interactors
Molecular INTeraction database More...MINTⁱ	Q9Y261
STRINGⁱ	9606.ENSP00000315955

Structureⁱ

Secondary structure

Legend: HelixTurnBeta strandPDB Structure known for this area

Feature key	Position(s)	DescriptionActions	Length
Helixⁱ	164 – 173	Combined sources	10
Beta strandⁱ	178 – 180	Combined sources	3
Helixⁱ	182 – 192	Combined sources	11
Helixⁱ	194 – 197	Combined sources	4
Helixⁱ	200 – 213	Combined sources	14
Beta strandⁱ	217 – 220	Combined sources	4
Beta strandⁱ	224 – 226	Combined sources	3
Beta strandⁱ	232 – 235	Combined sources	4

Show more details

3D structure databases

ProteinModelPortalⁱ	Q9Y261
SMRⁱ	Q9Y261
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Region

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Regionⁱ	14 – 93	Transactivation domain 1By similarityAdd BLAST		80
Regionⁱ	361 – 457	Transactivation domain 2By similarityAdd BLAST		97

Motif

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Motifⁱ	106 – 113	Nuclear localization signalBy similarity		8

Phylogenomic databases

eggNOGⁱ	KOG3563 Eukaryota COG5025 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00760000118904
HOGENOMⁱ	HOG000231817
HOVERGENⁱ	HBG006621
InParanoidⁱ	Q9Y261
KEGG Orthology (KO) More...KOⁱ	K08035
OMAⁱ	QEHKRGG
PhylomeDBⁱ	Q9Y261
TreeFamⁱ	TF316127

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd00059 FH, 1 hit
Gene3Dⁱ	1.10.10.10, 1 hit
InterProⁱ	View protein in InterPro IPR013638 Fork-head_N IPR001766 Fork_head_dom IPR018533 Forkhead_box_C IPR018122 TF_fork_head_CS_1 IPR030456 TF_fork_head_CS_2 IPR036388 WH-like_DNA-bd_sf IPR036390 WH_DNA-bd_sf
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00250 Forkhead, 1 hit PF08430 Forkhead_N, 1 hit PF09354 HNF_C, 1 hit
PRINTSⁱ	PR00053 FORKHEAD
SMARTⁱ	View protein in SMART SM00339 FH, 1 hit
SUPFAMⁱ	SSF46785 SSF46785, 1 hit
PROSITEⁱ	View protein in PROSITE PS00657 FORK_HEAD_1, 1 hit PS00658 FORK_HEAD_2, 1 hit PS50039 FORK_HEAD_3, 1 hit

Sequences (2)ⁱ

Sequence statusⁱ: Complete.

This entry describes 2 isoformsⁱ produced by alternative splicing. Align Add to basket

Isoform 1 (identifier: Q9Y261-1) [UniParc]FASTA Add to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MLGAVKMEGH EPSDWSSYYA EPEGYSSVSN MNAGLGMNGM NTYMSMSAAA 
        60         70         80         90        100
MGSGSGNMSA GSMNMSSYVG AGMSPSLAGM SPGAGAMAGM GGSAGAAGVA 
       110        120        130        140        150
GMGPHLSPSL SPLGGQAAGA MGGLAPYANM NSMSPMYGQA GLSRARDPKT 
       160        170        180        190        200
YRRSYTHAKP PYSYISLITM AIQQSPNKML TLSEIYQWIM DLFPFYRQNQ 
       210        220        230        240        250
QRWQNSIRHS LSFNDCFLKV PRSPDKPGKG SFWTLHPDSG NMFENGCYLR 
       260        270        280        290        300
RQKRFKCEKQ LALKEAAGAA GSGKKAAAGA QASQAQLGEA AGPASETPAG 
       310        320        330        340        350
TESPHSSASP CQEHKRGGLG ELKGTPAAAL SPPEPAPSPG QQQQAAAHLL 
       360        370        380        390        400
GPPHHPGLPP EAHLKPEHHY AFNHPFSINN LMSSEQQHHH SHHHHQPHKM 
       410        420        430        440        450
DLKAYEQVMH YPGYGSPMPG SLAMGPVTNK TGLDASPLAA DTSYYQGVYS 

RPIMNSS

Length:457

Mass (Da):48,306

Last modified:November 1, 1999 - v1

Checksum:ⁱ61DDE4C75C70680A

GO

Isoform 2 (identifier: Q9Y261-2) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
1-1: M → MHSASSM

« Hide

        10         20         30         40         50
MHSASSMLGA VKMEGHEPSD WSSYYAEPEG YSSVSNMNAG LGMNGMNTYM 
        60         70         80         90        100
SMSAAAMGSG SGNMSAGSMN MSSYVGAGMS PSLAGMSPGA GAMAGMGGSA 
       110        120        130        140        150
GAAGVAGMGP HLSPSLSPLG GQAAGAMGGL APYANMNSMS PMYGQAGLSR 
       160        170        180        190        200
ARDPKTYRRS YTHAKPPYSY ISLITMAIQQ SPNKMLTLSE IYQWIMDLFP 
       210        220        230        240        250
FYRQNQQRWQ NSIRHSLSFN DCFLKVPRSP DKPGKGSFWT LHPDSGNMFE 
       260        270        280        290        300
NGCYLRRQKR FKCEKQLALK EAAGAAGSGK KAAAGAQASQ AQLGEAAGPA 
       310        320        330        340        350
SETPAGTESP HSSASPCQEH KRGGLGELKG TPAAALSPPE PAPSPGQQQQ 
       360        370        380        390        400
AAAHLLGPPH HPGLPPEAHL KPEHHYAFNH PFSINNLMSS EQQHHHSHHH 
       410        420        430        440        450
HQPHKMDLKA YEQVMHYPGY GSPMPGSLAM GPVTNKTGLD ASPLAADTSY 
       460 
YQGVYSRPIM NSS

Show »

Length:463

Mass (Da):48,907

Checksum:ⁱ726495A18CAE1677

GO

Sequence cautionⁱ

The sequence AAH11780 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Natural variant

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Natural variantⁱVAR_008858	328	A → V in Japanese subjects with maturity-onset diabetes of the young; unknown pathological significance. 1 PublicationCorresponds to variant dbSNP:rs199796119Ensembl.		1

Alternative sequence

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Alternative sequenceⁱVSP_041212	1	M → MHSASSM in isoform 2. 1 Publication		1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AB028021 mRNA Translation: BAA78106.1 AF147787 Genomic DNA Translation: AAD41081.1 AF176110 Genomic DNA Translation: AAD51978.1 AL121722 Genomic DNA No translation available. BC006545 mRNA Translation: AAH06545.2 BC011780 mRNA Translation: AAH11780.1 Different initiation. BC019288 mRNA Translation: AAH19288.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS13147.1 [Q9Y261-1] CCDS46585.1 [Q9Y261-2]
NCBI Reference Sequences More...RefSeqⁱ	NP_068556.2, NM_021784.4 [Q9Y261-2] NP_710141.1, NM_153675.2 [Q9Y261-1]
UniGeneⁱ	Hs.155651

Genome annotation databases

Ensemblⁱ	ENST00000377115; ENSP00000366319; ENSG00000125798 [Q9Y261-1] ENST00000419308; ENSP00000400341; ENSG00000125798 [Q9Y261-2]
GeneIDⁱ	3170
KEGGⁱ	hsa:3170
UCSC genome browser More...UCSCⁱ	uc002wsm.4 human [Q9Y261-1]

Keywords - Coding sequence diversityⁱ

Alternative splicing, Polymorphism

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
Q9Y261	Forkhead box A2		HUMAN		463	UniRef100_Q9Y261
Isoform 2 of Hepatocyte nuclear factor 3-beta		HUMAN		463

Protein	Similar proteins		Species	Score	Length	Source
Q9Y261	Hepatocyte nuclear factor 3-beta		RAT		458	UniRef90_Q9Y261
Forkhead box A2		HUMAN		463
Forkhead box A2		CANLF		468
hepatocyte nuclear factor 3-beta isoform X1		MESAU		466
Uncharacterized protein		NEOLE		466
+118

Protein	Similar proteins		Species	Score	Length	Source
Q9Y261	Hepatocyte nuclear factor 3-beta		MOUSE		459	UniRef50_P35583
Hepatocyte nuclear factor 3-alpha		HUMAN		472
Hepatocyte nuclear factor 3-alpha		RAT		466
Uncharacterized protein		RABIT		471
Forkhead box A1		OTOGA		449
+285

Cross-referencesⁱ

Web resourcesⁱ

Wikipedia

Hepatocyte nuclear factors entry

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AB028021 mRNA Translation: BAA78106.1 AF147787 Genomic DNA Translation: AAD41081.1 AF176110 Genomic DNA Translation: AAD51978.1 AL121722 Genomic DNA No translation available. BC006545 mRNA Translation: AAH06545.2 BC011780 mRNA Translation: AAH11780.1 Different initiation. BC019288 mRNA Translation: AAH19288.1
CCDSⁱ	CCDS13147.1 [Q9Y261-1] CCDS46585.1 [Q9Y261-2]
RefSeqⁱ	NP_068556.2, NM_021784.4 [Q9Y261-2] NP_710141.1, NM_153675.2 [Q9Y261-1]
UniGeneⁱ	Hs.155651

3D structure databases

Select the link destinations: Protein Data Bank Europe More...PDBeⁱ Protein Data Bank RCSB More...RCSB PDBⁱ Protein Data Bank Japan More...PDBjⁱ Links Updated	PDB entry	Method	Resolution (Å)	Chain	Positions	PDBsum
	5X07	X-ray	2.80	C/F/I/L	157-258	[»]
ProteinModelPortalⁱ	Q9Y261
SMRⁱ	Q9Y261
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	109412, 18 interactors
IntActⁱ	Q9Y261, 10 interactors
MINTⁱ	Q9Y261
STRINGⁱ	9606.ENSP00000315955

PTM databases

iPTMnetⁱ	Q9Y261
PhosphoSitePlusⁱ	Q9Y261

Polymorphism and mutation databases

BioMutaⁱ	FOXA2
DMDMⁱ	8134491

Proteomic databases

PaxDbⁱ	Q9Y261
PeptideAtlasⁱ	Q9Y261
PRIDEⁱ	Q9Y261
ProteomicsDBⁱ	85664 85665 [Q9Y261-2]

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	3170
Structural Biology Knowledgebase	Search...

Genome annotation databases

Ensemblⁱ	ENST00000377115; ENSP00000366319; ENSG00000125798 [Q9Y261-1] ENST00000419308; ENSP00000400341; ENSG00000125798 [Q9Y261-2]
GeneIDⁱ	3170
KEGGⁱ	hsa:3170
UCSCⁱ	uc002wsm.4 human [Q9Y261-1]

Organism-specific databases

CTDⁱ	3170
DisGeNETⁱ	3170
EuPathDBⁱ	HostDB:ENSG00000125798.14
GeneCardsⁱ	FOXA2
HGNCⁱ	HGNC:5022 FOXA2
HPAⁱ	CAB001388 HPA066846
MIMⁱ	600288 gene
neXtProtⁱ	NX_Q9Y261
OpenTargetsⁱ	ENSG00000125798
PharmGKBⁱ	PA201091
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG3563 Eukaryota COG5025 LUCA
GeneTreeⁱ	ENSGT00760000118904
HOGENOMⁱ	HOG000231817
HOVERGENⁱ	HBG006621
InParanoidⁱ	Q9Y261
KOⁱ	K08035
OMAⁱ	QEHKRGG
PhylomeDBⁱ	Q9Y261
TreeFamⁱ	TF316127

Enzyme and pathway databases

Reactomeⁱ	R-HSA-210745 Regulation of gene expression in beta cells
SignaLinkⁱ	Q9Y261
SIGNORⁱ	Q9Y261

Miscellaneous databases

ChiTaRSⁱ	FOXA2 human
GeneWikiⁱ	FOXA2
GenomeRNAiⁱ	3170
Protein Ontology More...PROⁱ	PR:Q9Y261
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000125798 Expressed in 72 organ(s), highest expression level in endometrium
CleanExⁱ	HS_FOXA2
ExpressionAtlasⁱ	Q9Y261 baseline and differential
Genevisibleⁱ	Q9Y261 HS

Family and domain databases

CDDⁱ	cd00059 FH, 1 hit
Gene3Dⁱ	1.10.10.10, 1 hit
InterProⁱ	View protein in InterPro IPR013638 Fork-head_N IPR001766 Fork_head_dom IPR018533 Forkhead_box_C IPR018122 TF_fork_head_CS_1 IPR030456 TF_fork_head_CS_2 IPR036388 WH-like_DNA-bd_sf IPR036390 WH_DNA-bd_sf
Pfamⁱ	View protein in Pfam PF00250 Forkhead, 1 hit PF08430 Forkhead_N, 1 hit PF09354 HNF_C, 1 hit
PRINTSⁱ	PR00053 FORKHEAD
SMARTⁱ	View protein in SMART SM00339 FH, 1 hit
SUPFAMⁱ	SSF46785 SSF46785, 1 hit
PROSITEⁱ	View protein in PROSITE PS00657 FORK_HEAD_1, 1 hit PS00658 FORK_HEAD_2, 1 hit PS50039 FORK_HEAD_3, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	FOXA2_HUMAN
Accessionⁱ	Q9Y261Primary (citable) accession number: Q9Y261 Secondary accession number(s): Q8WUW4, Q96DF7
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	May 30, 2000
	Last sequence update:	November 1, 1999
	Last modified:	September 12, 2018
	This is version 182 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

3D-structure, Complete proteome, Reference proteome

Documents

PDB cross-references
Index of Protein Data Bank (PDB) cross-references
Human chromosome 20
Human chromosome 20: entries, gene names and cross-references to MIM
Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations
Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

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UniProtKB - Q9Y261 (FOXA2_HUMAN)

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Hepatocyte nuclear factor 3-beta

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Regions

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Nucleus

Other locations

Nucleus

Other locations

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Motif

Phylogenomic databases

Family and domain databases

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

Natural variant

Alternative sequence

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross_references_section">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

UniProt is an ELIXIR core data resource

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence cautionⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Web resourcesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ