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Protein

Choline/ethanolamine kinase

Gene

CHKB

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Has a key role in phospholipid biosynthesis. Catalyzes the first step in phosphatidylethanolamine biosynthesis. Phosphorylates ethanolamine, and can also act on choline (in vitro). Has higher activity with ethanolamine. May not significantly contribute to in vivo phosphatidylcholine biosynthesis.1 Publication

Miscellaneous

This protein is produced by a bicistronic gene which also produces the CPT1B protein from a non-overlapping reading frame.

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the ‘Function’ section describes biophysical and chemical properties, such as maximal absorption, kinetic parameters, pH dependence, redox potentials and temperature dependence.<p><a href='/help/biophysicochemical_properties' target='_top'>More...</a></p>Kineticsi

  1. KM=0.57 mM for choline1 Publication
  2. KM=2.9 mM for ethanolamine1 Publication

    <p>This subsection of the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section describes the metabolic pathway(s) associated with a protein.<p><a href='/help/pathway' target='_top'>More...</a></p>Pathwayi: phosphatidylethanolamine biosynthesis

    This protein is involved in step 1 of the subpathway that synthesizes phosphatidylethanolamine from ethanolamine.
    Proteins known to be involved in the 3 steps of the subpathway in this organism are:
    1. Ethanolamine kinase 1 (ETNK1), Ethanolamine kinase 2 (ETNK2), Choline/ethanolamine kinase (CHKB), Choline kinase alpha (CHKA)
    2. Ethanolamine-phosphate cytidylyltransferase (PCYT2)
    3. Choline/ethanolaminephosphotransferase 1 (CEPT1), Ethanolaminephosphotransferase 1 (SELENOI)
    This subpathway is part of the pathway phosphatidylethanolamine biosynthesis, which is itself part of Phospholipid metabolism.
    View all proteins of this organism that are known to be involved in the subpathway that synthesizes phosphatidylethanolamine from ethanolamine, the pathway phosphatidylethanolamine biosynthesis and in Phospholipid metabolism.

    Sites

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the ‘Function’ section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei104ATP1
    Binding sitei244ATPBy similarity1
    Binding sitei264ATP1

    Regions

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the ‘Function’ section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi75 – 81ATPBy similarity7
    Nucleotide bindingi146 – 152ATP7

    <p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

    • ATP binding Source: UniProtKB-KW
    • choline kinase activity Source: UniProtKB
    • ethanolamine kinase activity Source: UniProtKB

    GO - Biological processi

    <p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

    Molecular functionKinase, Transferase
    Biological processLipid biosynthesis, Lipid metabolism, Phospholipid biosynthesis, Phospholipid metabolism
    LigandATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BRENDA Comprehensive Enzyme Information System

    More...
    BRENDAi
    2.7.1.32 2681

    Reactome - a knowledgebase of biological pathways and processes

    More...
    Reactomei
    R-HSA-1483191 Synthesis of PC
    R-HSA-1483213 Synthesis of PE

    SABIO-RK: Biochemical Reaction Kinetics Database

    More...
    SABIO-RKi
    Q9Y259

    UniPathway: a resource for the exploration and annotation of metabolic pathways

    More...
    UniPathwayi
    UPA00558;UER00741

    Chemistry databases

    SwissLipids knowledge resource for lipid biology

    More...
    SwissLipidsi
    SLP:000001747 [Q9Y259-1]

    <p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
    Recommended name:
    Choline/ethanolamine kinase
    Alternative name(s):
    Choline kinase beta (EC:2.7.1.32)
    Short name:
    CK
    Short name:
    CKB
    Choline kinase-like protein
    Ethanolamine kinase (EC:2.7.1.82)
    Short name:
    EK
    Ethanolamine kinase beta
    Short name:
    EKB
    choline/ethanolamine kinase beta
    Short name:
    CKEKB
    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
    Name:CHKB
    Synonyms:CHETK, CHKL
    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
    • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 22

    Organism-specific databases

    Eukaryotic Pathogen Database Resources

    More...
    EuPathDBi
    HostDB:ENSG00000100288.19

    Human Gene Nomenclature Database

    More...
    HGNCi
    HGNC:1938 CHKB

    Online Mendelian Inheritance in Man (OMIM)

    More...
    MIMi
    612395 gene

    neXtProt; the human protein knowledge platform

    More...
    neXtProti
    NX_Q9Y259

    <p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

    Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

    <p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

    Organism-specific databases

    DisGeNET

    More...
    DisGeNETi
    1120

    GeneReviews a resource of expert-authored, peer-reviewed disease descriptions.

    More...
    GeneReviewsi
    CHKB

    MalaCards human disease database

    More...
    MalaCardsi
    CHKB

    Open Targets

    More...
    OpenTargetsi
    ENSG00000100288

    Orphanet; a database dedicated to information on rare diseases and orphan drugs

    More...
    Orphaneti
    280671 Megaconial congenital muscular dystrophy

    The Pharmacogenetics and Pharmacogenomics Knowledge Base

    More...
    PharmGKBi
    PA26469

    Chemistry databases

    ChEMBL database of bioactive drug-like small molecules

    More...
    ChEMBLi
    CHEMBL3112385

    Drug and drug target database

    More...
    DrugBanki
    DB00122 Choline

    Polymorphism and mutation databases

    BioMuta curated single-nucleotide variation and disease association database

    More...
    BioMutai
    CHKB

    Domain mapping of disease mutations (DMDM)

    More...
    DMDMi
    6685604

    <p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

    Molecule processing

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section indicates that the initiator methionine is cleaved from the mature protein.<p><a href='/help/init_met' target='_top'>More...</a></p>Initiator methionineiRemovedCombined sources1 Publication
    <p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002062222 – 395Choline/ethanolamine kinaseAdd BLAST394

    Amino acid modifications

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei2N-acetylalanineCombined sources1 Publication1

    Keywords - PTMi

    Acetylation

    Proteomic databases

    Encyclopedia of Proteome Dynamics

    More...
    EPDi
    Q9Y259

    PaxDb, a database of protein abundance averages across all three domains of life

    More...
    PaxDbi
    Q9Y259

    PeptideAtlas

    More...
    PeptideAtlasi
    Q9Y259

    PRoteomics IDEntifications database

    More...
    PRIDEi
    Q9Y259

    ProteomicsDB human proteome resource

    More...
    ProteomicsDBi
    85662
    85663 [Q9Y259-2]

    PTM databases

    iPTMnet integrated resource for PTMs in systems biology context

    More...
    iPTMneti
    Q9Y259

    Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

    More...
    PhosphoSitePlusi
    Q9Y259

    <p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

    Gene expression databases

    Bgee dataBase for Gene Expression Evolution

    More...
    Bgeei
    ENSG00000100288 Expressed in 90 organ(s), highest expression level in pituitary gland

    CleanEx database of gene expression profiles

    More...
    CleanExi
    HS_CHKB

    ExpressionAtlas, Differential and Baseline Expression

    More...
    ExpressionAtlasi
    Q9Y259 baseline and differential

    Genevisible search portal to normalized and curated expression data from Genevestigator

    More...
    Genevisiblei
    Q9Y259 HS

    Organism-specific databases

    Human Protein Atlas

    More...
    HPAi
    HPA018797

    <p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

    <p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

    Homodimer, and heterodimer with CHKA.1 Publication

    Protein-protein interaction databases

    The Biological General Repository for Interaction Datasets (BioGrid)

    More...
    BioGridi
    107544, 1 interactor

    Protein interaction database and analysis system

    More...
    IntActi
    Q9Y259, 1 interactor

    STRING: functional protein association networks

    More...
    STRINGi
    9606.ENSP00000384400

    Chemistry databases

    BindingDB database of measured binding affinities

    More...
    BindingDBi
    Q9Y259

    <p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

    Secondary structure

    1395
    Legend: HelixTurnBeta strandPDB Structure known for this area
    Show more details

    3D structure databases

    Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

    More...
    ProteinModelPortali
    Q9Y259

    SWISS-MODEL Repository - a database of annotated 3D protein structure models

    More...
    SMRi
    Q9Y259

    Database of comparative protein structure models

    More...
    ModBasei
    Search...

    MobiDB: a database of protein disorder and mobility annotations

    More...
    MobiDBi
    Search...

    Miscellaneous databases

    Relative evolutionary importance of amino acids within a protein sequence

    More...
    EvolutionaryTracei
    Q9Y259

    <p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

    Region

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni77 – 79Substrate bindingBy similarity3

    <p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

    Belongs to the choline/ethanolamine kinase family.Curated

    Phylogenomic databases

    evolutionary genealogy of genes: Non-supervised Orthologous Groups

    More...
    eggNOGi
    KOG2686 Eukaryota
    COG0510 LUCA

    Ensembl GeneTree

    More...
    GeneTreei
    ENSGT00940000153842

    The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

    More...
    HOGENOMi
    HOG000041274

    The HOVERGEN Database of Homologous Vertebrate Genes

    More...
    HOVERGENi
    HBG050943

    InParanoid: Eukaryotic Ortholog Groups

    More...
    InParanoidi
    Q9Y259

    KEGG Orthology (KO)

    More...
    KOi
    K14156

    Identification of Orthologs from Complete Genome Data

    More...
    OMAi
    MVMPFNK

    Database of Orthologous Groups

    More...
    OrthoDBi
    EOG091G06UK

    Database for complete collections of gene phylogenies

    More...
    PhylomeDBi
    Q9Y259

    TreeFam database of animal gene trees

    More...
    TreeFami
    TF313549

    Family and domain databases

    Integrated resource of protein families, domains and functional sites

    More...
    InterProi
    View protein in InterPro
    IPR026712 Cho/Etha_kinase
    IPR011009 Kinase-like_dom_sf

    The PANTHER Classification System

    More...
    PANTHERi
    PTHR22603:SF35 PTHR22603:SF35, 1 hit

    Superfamily database of structural and functional annotation

    More...
    SUPFAMi
    SSF56112 SSF56112, 1 hit

    <p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2)i

    <p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

    <p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

    This entry describes 2 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
    Isoform 1 (identifier: Q9Y259-1) [UniParc]FASTAAdd to basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide
            10         20         30         40         50
    MAAEATAVAG SGAVGGCLAK DGLQQSKCPD TTPKRRRASS LSRDAERRAY
    60 70 80 90 100
    QWCREYLGGA WRRVQPEELR VYPVSGGLSN LLFRCSLPDH LPSVGEEPRE
    110 120 130 140 150
    VLLRLYGAIL QGVDSLVLES VMFAILAERS LGPQLYGVFP EGRLEQYIPS
    160 170 180 190 200
    RPLKTQELRE PVLSAAIATK MAQFHGMEMP FTKEPHWLFG TMERYLKQIQ
    210 220 230 240 250
    DLPPTGLPEM NLLEMYSLKD EMGNLRKLLE STPSPVVFCH NDIQEGNILL
    260 270 280 290 300
    LSEPENADSL MLVDFEYSSY NYRGFDIGNH FCEWVYDYTH EEWPFYKARP
    310 320 330 340 350
    TDYPTQEQQL HFIRHYLAEA KKGETLSQEE QRKLEEDLLV EVSRYALASH
    360 370 380 390
    FFWGLWSILQ ASMSTIEFGY LDYAQSRFQF YFQQKGQLTS VHSSS
    Length:395
    Mass (Da):45,271
    Last modified:January 23, 2007 - v3
    <p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i18367468B22FB9CE
    GO
    Isoform 2 (identifier: Q9Y259-2) [UniParc]FASTAAdd to basket

    The sequence of this isoform differs from the canonical sequence as follows:
         75-127: SGGLSNLLFR...LESVMFAILA → RWEVRGQPLR...WPGGGRGRGR
         128-395: Missing.

    Show »
    Length:127
    Mass (Da):13,506
    Checksum:i1C3DBAB66A5D1637
    GO

    <p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

    The sequence AAB03342 differs from that shown. Reason: Erroneous gene model prediction.Curated

    Alternative sequence

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting. The information stored in this subsection is used to automatically construct alternative protein sequence(s) for display.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_03424875 – 127SGGLS…FAILA → RWEVRGQPLRCADRGQGSAA GPSGCSMFSPPSCARAWGGA GPAWPGGGRGRGR in isoform 2. CuratedAdd BLAST53
    Alternative sequenceiVSP_034249128 – 395Missing in isoform 2. CuratedAdd BLAST268

    Sequence databases

    Select the link destinations:

    EMBL nucleotide sequence database

    More...
    EMBLi

    GenBank nucleotide sequence database

    More...
    GenBanki

    DNA Data Bank of Japan; a nucleotide sequence database

    More...
    DDBJi
    Links Updated
    AB029885 Genomic DNA Translation: BAA82511.1
    AB029886 mRNA Translation: BAA82512.1
    AL096780 mRNA Translation: CAB46629.1
    AL096781 mRNA Translation: CAB46630.1
    CR456419 mRNA Translation: CAG30305.1
    AK314324 mRNA Translation: BAG36972.1
    U62317 Genomic DNA Translation: AAB03342.2 Sequence problems.
    CH471138 Genomic DNA Translation: EAW73573.1
    BC082263 mRNA Translation: AAH82263.1
    BC101488 mRNA Translation: AAI01489.1
    BC113521 mRNA Translation: AAI13522.2

    The Consensus CDS (CCDS) project

    More...
    CCDSi
    CCDS14099.1 [Q9Y259-1]

    NCBI Reference Sequences

    More...
    RefSeqi
    NP_005189.2, NM_005198.4 [Q9Y259-1]

    UniGene gene-oriented nucleotide sequence clusters

    More...
    UniGenei
    Hs.654827

    Genome annotation databases

    Ensembl eukaryotic genome annotation project

    More...
    Ensembli
    ENST00000406938; ENSP00000384400; ENSG00000100288 [Q9Y259-1]

    Database of genes from NCBI RefSeq genomes

    More...
    GeneIDi
    1120

    KEGG: Kyoto Encyclopedia of Genes and Genomes

    More...
    KEGGi
    hsa:1120

    UCSC genome browser

    More...
    UCSCi
    uc003bmv.4 human [Q9Y259-1]

    Keywords - Coding sequence diversityi

    Alternative splicing

    <p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

    <p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBLi
    GenBanki
    DDBJi
    Links Updated
    AB029885 Genomic DNA Translation: BAA82511.1
    AB029886 mRNA Translation: BAA82512.1
    AL096780 mRNA Translation: CAB46629.1
    AL096781 mRNA Translation: CAB46630.1
    CR456419 mRNA Translation: CAG30305.1
    AK314324 mRNA Translation: BAG36972.1
    U62317 Genomic DNA Translation: AAB03342.2 Sequence problems.
    CH471138 Genomic DNA Translation: EAW73573.1
    BC082263 mRNA Translation: AAH82263.1
    BC101488 mRNA Translation: AAI01489.1
    BC113521 mRNA Translation: AAI13522.2
    CCDSiCCDS14099.1 [Q9Y259-1]
    RefSeqiNP_005189.2, NM_005198.4 [Q9Y259-1]
    UniGeneiHs.654827

    3D structure databases

    Select the link destinations:

    Protein Data Bank Europe

    More...
    PDBei

    Protein Data Bank RCSB

    More...
    RCSB PDBi

    Protein Data Bank Japan

    More...
    PDBji
    Links Updated
    PDB entryMethodResolution (Å)ChainPositionsPDBsum
    2IG7X-ray1.80A/B14-395[»]
    3FEGX-ray1.30A35-395[»]
    3LQ3X-ray1.42A14-395[»]
    ProteinModelPortaliQ9Y259
    SMRiQ9Y259
    ModBaseiSearch...
    MobiDBiSearch...

    Protein-protein interaction databases

    BioGridi107544, 1 interactor
    IntActiQ9Y259, 1 interactor
    STRINGi9606.ENSP00000384400

    Chemistry databases

    BindingDBiQ9Y259
    ChEMBLiCHEMBL3112385
    DrugBankiDB00122 Choline
    SwissLipidsiSLP:000001747 [Q9Y259-1]

    PTM databases

    iPTMnetiQ9Y259
    PhosphoSitePlusiQ9Y259

    Polymorphism and mutation databases

    BioMutaiCHKB
    DMDMi6685604

    Proteomic databases

    EPDiQ9Y259
    PaxDbiQ9Y259
    PeptideAtlasiQ9Y259
    PRIDEiQ9Y259
    ProteomicsDBi85662
    85663 [Q9Y259-2]

    Protocols and materials databases

    The DNASU plasmid repository

    More...
    DNASUi
    1120
    Structural Biology KnowledgebaseSearch...

    Genome annotation databases

    EnsembliENST00000406938; ENSP00000384400; ENSG00000100288 [Q9Y259-1]
    GeneIDi1120
    KEGGihsa:1120
    UCSCiuc003bmv.4 human [Q9Y259-1]

    Organism-specific databases

    Comparative Toxicogenomics Database

    More...
    CTDi
    1120
    DisGeNETi1120
    EuPathDBiHostDB:ENSG00000100288.19

    GeneCards: human genes, protein and diseases

    More...
    GeneCardsi
    CHKB
    GeneReviewsiCHKB
    HGNCiHGNC:1938 CHKB
    HPAiHPA018797
    MalaCardsiCHKB
    MIMi612395 gene
    neXtProtiNX_Q9Y259
    OpenTargetsiENSG00000100288
    Orphaneti280671 Megaconial congenital muscular dystrophy
    PharmGKBiPA26469

    GenAtlas: human gene database

    More...
    GenAtlasi
    Search...

    Phylogenomic databases

    eggNOGiKOG2686 Eukaryota
    COG0510 LUCA
    GeneTreeiENSGT00940000153842
    HOGENOMiHOG000041274
    HOVERGENiHBG050943
    InParanoidiQ9Y259
    KOiK14156
    OMAiMVMPFNK
    OrthoDBiEOG091G06UK
    PhylomeDBiQ9Y259
    TreeFamiTF313549

    Enzyme and pathway databases

    UniPathwayi
    UPA00558;UER00741

    BRENDAi2.7.1.32 2681
    ReactomeiR-HSA-1483191 Synthesis of PC
    R-HSA-1483213 Synthesis of PE
    SABIO-RKiQ9Y259

    Miscellaneous databases

    EvolutionaryTraceiQ9Y259

    The Gene Wiki collection of pages on human genes and proteins

    More...
    GeneWikii
    CHKB_(gene)

    Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

    More...
    GenomeRNAii
    1120

    Protein Ontology

    More...
    PROi
    PR:Q9Y259

    The Stanford Online Universal Resource for Clones and ESTs

    More...
    SOURCEi
    Search...

    Gene expression databases

    BgeeiENSG00000100288 Expressed in 90 organ(s), highest expression level in pituitary gland
    CleanExiHS_CHKB
    ExpressionAtlasiQ9Y259 baseline and differential
    GenevisibleiQ9Y259 HS

    Family and domain databases

    InterProiView protein in InterPro
    IPR026712 Cho/Etha_kinase
    IPR011009 Kinase-like_dom_sf
    PANTHERiPTHR22603:SF35 PTHR22603:SF35, 1 hit
    SUPFAMiSSF56112 SSF56112, 1 hit

    ProtoNet; Automatic hierarchical classification of proteins

    More...
    ProtoNeti
    Search...

    <p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

    <p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiCHKB_HUMAN
    <p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9Y259
    Secondary accession number(s): A0PJM6, Q13388
    <p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 30, 2000
    Last sequence update: January 23, 2007
    Last modified: December 5, 2018
    This is version 150 of the entry and version 3 of the sequence. See complete history.
    <p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    <p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    2. SIMILARITY comments
      Index of protein domains and families
    3. Human chromosome 22
      Human chromosome 22: entries, gene names and cross-references to MIM
    4. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    5. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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