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Protein

C-C motif chemokine 26

Gene

CCL26

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Chemoattractant for eosinophils and basophils (PubMed:10415065, PubMed:10488147). Acts as a ligand for C-C chemokine receptor CCR3 which triggers Ca2+ mobilization in eosinophils (PubMed:10415065, PubMed:10488147, PubMed:11425309).3 Publications

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionCytokine
Biological processChemotaxis, Inflammatory response

Names & Taxonomyi

Protein namesi
Recommended name:
C-C motif chemokine 26
Alternative name(s):
CC chemokine IMAC
Eotaxin-3
Macrophage inflammatory protein 4-alpha
Short name:
MIP-4-alpha
Small-inducible cytokine A26
Thymic stroma chemokine-1
Short name:
TSC-1
Gene namesi
Name:CCL26
Synonyms:SCYA26
ORF Names:UNQ216/PRO242
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 7

Organism-specific databases

EuPathDBiHostDB:ENSG00000006606.8
HGNCiHGNC:10625 CCL26
MIMi604697 gene
neXtProtiNX_Q9Y258

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

DisGeNETi10344
OpenTargetsiENSG00000006606
PharmGKBiPA35557

Polymorphism and mutation databases

BioMutaiCCL26
DMDMi6685990

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 231 PublicationAdd BLAST23
ChainiPRO_000000523824 – 94C-C motif chemokine 26Add BLAST71

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi33 ↔ 57
Disulfide bondi34 ↔ 73

Keywords - PTMi

Disulfide bond

Proteomic databases

PaxDbiQ9Y258
PeptideAtlasiQ9Y258
PRIDEiQ9Y258
ProteomicsDBi85661

PTM databases

iPTMnetiQ9Y258
PhosphoSitePlusiQ9Y258

Expressioni

Tissue specificityi

Ubiquitously expressed at low levels in various tissues including heart and ovary.2 Publications

Gene expression databases

BgeeiENSG00000006606 Expressed in 89 organ(s), highest expression level in adenohypophysis
CleanExiHS_CCL26
GenevisibleiQ9Y258 HS

Interactioni

Subunit structurei

Monomer.1 Publication

Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

BioGridi115626, 19 interactors
DIPiDIP-5877N
IntActiQ9Y258, 23 interactors
MINTiQ9Y258
STRINGi9606.ENSP00000005180

Structurei

Secondary structure

194
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

DisProtiDP00696
ProteinModelPortaliQ9Y258
SMRiQ9Y258
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ9Y258

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410JIGC Eukaryota
ENOG41115YQ LUCA
GeneTreeiENSGT00900000140870
HOGENOMiHOG000036685
HOVERGENiHBG017871
InParanoidiQ9Y258
KOiK21096
OMAiCSQQAVI
OrthoDBiEOG091G14Y2
PhylomeDBiQ9Y258
TreeFamiTF334888

Family and domain databases

InterProiView protein in InterPro
IPR000827 Chemokine_CC_CS
IPR001811 Chemokine_IL8-like_dom
IPR036048 Interleukin_8-like_sf
PfamiView protein in Pfam
PF00048 IL8, 1 hit
SMARTiView protein in SMART
SM00199 SCY, 1 hit
SUPFAMiSSF54117 SSF54117, 1 hit
PROSITEiView protein in PROSITE
PS00472 SMALL_CYTOKINES_CC, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9Y258-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MMGLSLASAV LLASLLSLHL GTATRGSDIS KTCCFQYSHK PLPWTWVRSY
60 70 80 90
EFTSNSCSQR AVIFTTKRGK KVCTHPRKKW VQKYISLLKT PKQL
Length:94
Mass (Da):10,648
Last modified:November 1, 1999 - v1
Checksum:i8525B1E4BDD39A5F
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_02919218L → R. Corresponds to variant dbSNP:rs11465333Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF124601 mRNA Translation: AAD22197.1
AB016542 mRNA Translation: BAA36704.1
AB010447 mRNA Translation: BAA84579.1
AF096296 mRNA Translation: AAF09265.1
AF142434 mRNA Translation: AAD46495.1
EF064763 Genomic DNA Translation: ABK41946.1
AY358893 mRNA Translation: AAQ89252.1
AC005102 Genomic DNA Translation: AAD15411.1
CH471220 Genomic DNA Translation: EAW71771.1
BC069394 mRNA Translation: AAH69394.1
BC093773 mRNA Translation: AAH93773.1
BC101665 mRNA Translation: AAI01666.1
CCDSiCCDS5578.1
RefSeqiNP_006063.1, NM_006072.4
XP_016867161.1, XM_017011672.1
UniGeneiHs.131342

Genome annotation databases

EnsembliENST00000005180; ENSP00000005180; ENSG00000006606
ENST00000394905; ENSP00000378365; ENSG00000006606
GeneIDi10344
KEGGihsa:10344
UCSCiuc003udt.2 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Cross-referencesi

Web resourcesi

Wikipedia

CCL26 entry

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF124601 mRNA Translation: AAD22197.1
AB016542 mRNA Translation: BAA36704.1
AB010447 mRNA Translation: BAA84579.1
AF096296 mRNA Translation: AAF09265.1
AF142434 mRNA Translation: AAD46495.1
EF064763 Genomic DNA Translation: ABK41946.1
AY358893 mRNA Translation: AAQ89252.1
AC005102 Genomic DNA Translation: AAD15411.1
CH471220 Genomic DNA Translation: EAW71771.1
BC069394 mRNA Translation: AAH69394.1
BC093773 mRNA Translation: AAH93773.1
BC101665 mRNA Translation: AAI01666.1
CCDSiCCDS5578.1
RefSeqiNP_006063.1, NM_006072.4
XP_016867161.1, XM_017011672.1
UniGeneiHs.131342

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1G2SNMR-A24-94[»]
1G2TNMR-A24-94[»]
DisProtiDP00696
ProteinModelPortaliQ9Y258
SMRiQ9Y258
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi115626, 19 interactors
DIPiDIP-5877N
IntActiQ9Y258, 23 interactors
MINTiQ9Y258
STRINGi9606.ENSP00000005180

PTM databases

iPTMnetiQ9Y258
PhosphoSitePlusiQ9Y258

Polymorphism and mutation databases

BioMutaiCCL26
DMDMi6685990

Proteomic databases

PaxDbiQ9Y258
PeptideAtlasiQ9Y258
PRIDEiQ9Y258
ProteomicsDBi85661

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000005180; ENSP00000005180; ENSG00000006606
ENST00000394905; ENSP00000378365; ENSG00000006606
GeneIDi10344
KEGGihsa:10344
UCSCiuc003udt.2 human

Organism-specific databases

CTDi10344
DisGeNETi10344
EuPathDBiHostDB:ENSG00000006606.8
GeneCardsiCCL26
HGNCiHGNC:10625 CCL26
MIMi604697 gene
neXtProtiNX_Q9Y258
OpenTargetsiENSG00000006606
PharmGKBiPA35557
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410JIGC Eukaryota
ENOG41115YQ LUCA
GeneTreeiENSGT00900000140870
HOGENOMiHOG000036685
HOVERGENiHBG017871
InParanoidiQ9Y258
KOiK21096
OMAiCSQQAVI
OrthoDBiEOG091G14Y2
PhylomeDBiQ9Y258
TreeFamiTF334888

Miscellaneous databases

EvolutionaryTraceiQ9Y258
GenomeRNAii10344
PROiPR:Q9Y258
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000006606 Expressed in 89 organ(s), highest expression level in adenohypophysis
CleanExiHS_CCL26
GenevisibleiQ9Y258 HS

Family and domain databases

InterProiView protein in InterPro
IPR000827 Chemokine_CC_CS
IPR001811 Chemokine_IL8-like_dom
IPR036048 Interleukin_8-like_sf
PfamiView protein in Pfam
PF00048 IL8, 1 hit
SMARTiView protein in SMART
SM00199 SCY, 1 hit
SUPFAMiSSF54117 SSF54117, 1 hit
PROSITEiView protein in PROSITE
PS00472 SMALL_CYTOKINES_CC, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiCCL26_HUMAN
AccessioniPrimary (citable) accession number: Q9Y258
Secondary accession number(s): A0N0Q5, Q52LV8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: November 1, 1999
Last modified: September 12, 2018
This is version 158 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families
  3. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
  4. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
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Main funding by: National Institutes of Health

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