UniProtKB - Q9Y253 (POLH_HUMAN)
DNA polymerase eta
POLH
Functioni
Catalytic activityi
- EC:2.7.7.71 Publication
Cofactori
Activity regulationi
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Metal bindingi | 13 | Magnesium 1 or manganese 1Combined sources1 Publication | 1 | |
Metal bindingi | 13 | Magnesium 2 or manganese 2Combined sources1 Publication | 1 | |
Metal bindingi | 14 | Magnesium 1 or manganese 1; via carbonyl oxygenCombined sources1 Publication | 1 | |
Binding sitei | 61 | dNTP1 Publication | 1 | |
Metal bindingi | 115 | Magnesium 1 or manganese 1Combined sources1 Publication | 1 | |
Metal bindingi | 115 | Magnesium 2 or manganese 2Combined sources1 Publication | 1 | |
Metal bindingi | 116 | Magnesium 2 or manganese 2Combined sources1 Publication | 1 | |
Metal bindingi | 635 | ZincCombined sources1 Publication | 1 | |
Metal bindingi | 638 | ZincCombined sources1 Publication | 1 | |
Metal bindingi | 650 | Zinc; via tele nitrogenCombined sources1 Publication | 1 | |
Metal bindingi | 654 | Zinc; via tele nitrogenCombined sources1 Publication | 1 |
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 628 – 662 | UBZ3-typePROSITE-ProRule annotationAdd BLAST | 35 |
GO - Molecular functioni
- damaged DNA binding Source: ProtInc
- DNA-directed DNA polymerase activity Source: GO_Central
- metal ion binding Source: UniProtKB-KW
GO - Biological processi
- cellular response to UV-C Source: Ensembl
- DNA repair Source: ProtInc
- DNA replication Source: UniProtKB-KW
- DNA synthesis involved in DNA repair Source: UniProtKB
- error-free translesion synthesis Source: Reactome
- error-prone translesion synthesis Source: GO_Central
- pyrimidine dimer repair Source: Ensembl
- regulation of DNA repair Source: ProtInc
- response to radiation Source: GO_Central
- response to UV-C Source: UniProtKB
- translesion synthesis Source: Reactome
Keywordsi
Molecular function | DNA-binding, DNA-directed DNA polymerase, Mutator protein, Nucleotidyltransferase, Transferase |
Biological process | DNA damage, DNA repair, DNA replication, DNA synthesis |
Ligand | Magnesium, Metal-binding, Schiff base, Zinc |
Enzyme and pathway databases
BRENDAi | 2.7.7.7, 2681 |
PathwayCommonsi | Q9Y253 |
Reactomei | R-HSA-110320, Translesion Synthesis by POLH R-HSA-5656169, Termination of translesion DNA synthesis R-HSA-5685942, HDR through Homologous Recombination (HRR) |
SABIO-RKi | Q9Y253 |
SIGNORi | Q9Y253 |
Names & Taxonomyi
Protein namesi | Recommended name: DNA polymerase eta (EC:2.7.7.71 Publication)Alternative name(s): RAD30 homolog A Xeroderma pigmentosum variant type protein |
Gene namesi | Name:POLH Synonyms:RAD30, RAD30A, XPV |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
EuPathDBi | HostDB:ENSG00000170734.11 |
HGNCi | HGNC:9181, POLH |
MIMi | 603968, gene |
neXtProti | NX_Q9Y253 |
Subcellular locationi
Nucleus
- Nucleus 4 Publications
Note: Binding to ubiquitinated PCNA mediates colocalization to replication foci during DNA replication and persists at sites of stalled replication forks following UV irradiation (PubMed:12606586, PubMed:16357261, PubMed:24553286). After UV irradiation, recruited to DNA damage sites within 1 hour, to a maximum of about 80%; this recruitment may not be not restricted to cells active in DNA replication (PubMed:22801543). Colocalizes with TRAIP to nuclear foci (PubMed:24553286).4 Publications
Cytosol
- cytosol Source: HPA
Nucleus
- nucleoplasm Source: HPA
- nucleus Source: GO_Central
Other locations
- replication fork Source: GO_Central
- site of double-strand break Source: GO_Central
Keywords - Cellular componenti
NucleusPathology & Biotechi
Involvement in diseasei
Xeroderma pigmentosum variant type (XPV)6 Publications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_070835 | 37 | Missing in XPV. 1 Publication | 1 | |
Natural variantiVAR_021226 | 75 | Missing in XPV; impairs translesion synthesis. 2 Publications | 1 | |
Natural variantiVAR_070836 | 93 | R → P in XPV. 1 PublicationCorresponds to variant dbSNP:rs756931657Ensembl. | 1 | |
Natural variantiVAR_021227 | 111 | R → H in XPV. Corresponds to variant dbSNP:rs758423288Ensembl. | 1 | |
Natural variantiVAR_021228 | 122 | T → P in XPV. 1 PublicationCorresponds to variant dbSNP:rs1561900151Ensembl. | 1 | |
Natural variantiVAR_021230 | 263 | G → V in XPV; impairs translesion synthesis. 1 PublicationCorresponds to variant dbSNP:rs1413703153Ensembl. | 1 | |
Natural variantiVAR_070837 | 266 | V → D in XPV. 1 Publication | 1 | |
Natural variantiVAR_070838 | 295 | G → R in XPV. 1 Publication | 1 | |
Natural variantiVAR_021232 | 361 | R → S in XPV. 1 Publication | 1 | |
Natural variantiVAR_021234 | 535 | K → E in XPV. 1 PublicationCorresponds to variant dbSNP:rs56307355EnsemblClinVar. | 1 | |
Natural variantiVAR_021236 | 589 | K → T in XPV. 1 PublicationCorresponds to variant dbSNP:rs121908565EnsemblClinVar. | 1 | |
Natural variantiVAR_070839 | 692 | T → A in XPV. 1 PublicationCorresponds to variant dbSNP:rs199562456Ensembl. | 1 |
Mutagenesis
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Mutagenesisi | 52 | Y → A or F: Reduces DNA polymerase activity. 1 Publication | 1 | |
Mutagenesisi | 52 | Y → E: Reduces DNA polymerase activity. Increases fidelity of replication and reduces translesion bypass. 1 Publication | 1 | |
Mutagenesisi | 61 | R → A: Reduces enzymatic activity by two-thirds. 1 Publication | 1 | |
Mutagenesisi | 62 | S → G: Increased DNA polymerase activity and translesion bypass compared to wild-type. 1 Publication | 1 | |
Mutagenesisi | 68 | A → S or V: Severe reduction in thymine dimer translesion bypass. 1 Publication | 1 | |
Mutagenesisi | 324 – 326 | NFP → AAA: Reduces binding to chromatin and to monoubiquitinated PCNA. Abolishes binding to monoubiquitinated PCNA; when associated with 705-E--H-713 Del. 1 Publication | 3 | |
Mutagenesisi | 638 | C → A: Reduces cell resistance to UV-induced DNA damage. 1 Publication | 1 | |
Mutagenesisi | 652 | D → A: Abolishes ubiquitin binding and localization to nuclear foci after UV-induced DNA damage but does not affect catalytic activity. 1 Publication | 1 | |
Mutagenesisi | 705 – 713 | Missing : Reduces cell resistance to UV-induced DNA damage. Reduces binding to chromatin and to monoubiquitinated PCNA. Abolishes binding to monoubiquitinated PCNA; when associated with 324-A--A-326. 2 Publications | 9 |
Keywords - Diseasei
Disease mutation, Xeroderma pigmentosumOrganism-specific databases
DisGeNETi | 5429 |
GeneReviewsi | POLH |
MalaCardsi | POLH |
MIMi | 278750, phenotype |
OpenTargetsi | ENSG00000170734 |
Orphaneti | 90342, Xeroderma pigmentosum variant |
PharmGKBi | PA279 |
Miscellaneous databases
Pharosi | Q9Y253, Tbio |
Chemistry databases
ChEMBLi | CHEMBL5542 |
Polymorphism and mutation databases
BioMutai | POLH |
DMDMi | 59798441 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000173986 | 1 – 713 | DNA polymerase etaAdd BLAST | 713 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Cross-linki | 682 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)1 Publication | ||
Cross-linki | 686 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)1 Publication | ||
Cross-linki | 694 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)1 Publication | ||
Cross-linki | 709 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)1 Publication |
Post-translational modificationi
Keywords - PTMi
Isopeptide bond, Ubl conjugationProteomic databases
EPDi | Q9Y253 |
jPOSTi | Q9Y253 |
MassIVEi | Q9Y253 |
PaxDbi | Q9Y253 |
PeptideAtlasi | Q9Y253 |
PRIDEi | Q9Y253 |
ProteomicsDBi | 85655 [Q9Y253-1] 85656 [Q9Y253-2] |
PTM databases
iPTMneti | Q9Y253 |
PhosphoSitePlusi | Q9Y253 |
Expressioni
Gene expression databases
Bgeei | ENSG00000170734, Expressed in buccal mucosa cell and 247 other tissues |
ExpressionAtlasi | Q9Y253, baseline and differential |
Genevisiblei | Q9Y253, HS |
Organism-specific databases
HPAi | ENSG00000170734, Low tissue specificity |
Interactioni
Subunit structurei
Interacts with REV1 (By similarity).
Interacts with monoubiquitinated PCNA, but not unmodified PCNA (PubMed:15149598).
Interacts with POLI; this interaction targets POLI to the replication machinery (PubMed:12606586).
Interacts with PALB2 and BRCA2; the interactions are direct and are required to sustain the recruitment of POLH at blocked replication forks and to stimulate POLH-dependent DNA synthesis on D loop substrates (PubMed:24485656).
Interacts (via C-terminus) with TRAIP (PubMed:24553286).
Interacts with ubiquitin (PubMed:16357261).
Interacts with POLDIP2 (PubMed:20554254).
By similarity6 PublicationsBinary interactionsi
Hide detailsQ9Y253
With | #Exp. | IntAct |
---|---|---|
BRCA2 [P51587] | 6 | EBI-2827270,EBI-79792 |
PALB2 [Q86YC2] | 7 | EBI-2827270,EBI-1222653 |
PCNA [Q6FI35] | 3 | EBI-2827270,EBI-8469539 |
UBC [P0CG48] | 4 | EBI-2827270,EBI-3390054 |
Protein-protein interaction databases
BioGRIDi | 111425, 44 interactors |
CORUMi | Q9Y253 |
IntActi | Q9Y253, 23 interactors |
MINTi | Q9Y253 |
STRINGi | 9606.ENSP00000361310 |
Chemistry databases
BindingDBi | Q9Y253 |
Miscellaneous databases
RNActi | Q9Y253, protein |
Structurei
Secondary structure
3D structure databases
BMRBi | Q9Y253 |
SMRi | Q9Y253 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | Q9Y253 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 9 – 259 | UmuCPROSITE-ProRule annotationAdd BLAST | 251 |
Motif
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Motifi | 701 – 708 | PIP-box2 Publications | 8 |
Domaini
Sequence similaritiesi
Zinc finger
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 628 – 662 | UBZ3-typePROSITE-ProRule annotationAdd BLAST | 35 |
Keywords - Domaini
Zinc-fingerPhylogenomic databases
eggNOGi | KOG2095, Eukaryota |
GeneTreei | ENSGT00940000157048 |
HOGENOMi | CLU_012348_7_2_1 |
InParanoidi | Q9Y253 |
OMAi | DYHFAME |
OrthoDBi | 20162at2759 |
PhylomeDBi | Q9Y253 |
TreeFami | TF103010 |
Family and domain databases
Gene3Di | 3.30.1490.100, 1 hit 3.30.70.270, 1 hit |
IDEALi | IID00108 |
InterProi | View protein in InterPro IPR043502, DNA/RNA_pol_sf IPR036775, DNA_pol_Y-fam_lit_finger_sf IPR017961, DNA_pol_Y-fam_little_finger IPR043128, Rev_trsase/Diguanyl_cyclase IPR041298, UBZ3 IPR001126, UmuC |
Pfami | View protein in Pfam PF00817, IMS, 1 hit PF11799, IMS_C, 1 hit PF18439, zf_UBZ, 1 hit |
SUPFAMi | SSF100879, SSF100879, 1 hit SSF56672, SSF56672, 1 hit |
PROSITEi | View protein in PROSITE PS50173, UMUC, 1 hit PS51907, ZF_UBZ3, 1 hit |
s (2+)i Sequence
Sequence statusi: Complete.
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 2 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MATGQDRVVA LVDMDCFFVQ VEQRQNPHLR NKPCAVVQYK SWKGGGIIAV
60 70 80 90 100
SYEARAFGVT RSMWADDAKK LCPDLLLAQV RESRGKANLT KYREASVEVM
110 120 130 140 150
EIMSRFAVIE RASIDEAYVD LTSAVQERLQ KLQGQPISAD LLPSTYIEGL
160 170 180 190 200
PQGPTTAEET VQKEGMRKQG LFQWLDSLQI DNLTSPDLQL TVGAVIVEEM
210 220 230 240 250
RAAIERETGF QCSAGISHNK VLAKLACGLN KPNRQTLVSH GSVPQLFSQM
260 270 280 290 300
PIRKIRSLGG KLGASVIEIL GIEYMGELTQ FTESQLQSHF GEKNGSWLYA
310 320 330 340 350
MCRGIEHDPV KPRQLPKTIG CSKNFPGKTA LATREQVQWW LLQLAQELEE
360 370 380 390 400
RLTKDRNDND RVATQLVVSI RVQGDKRLSS LRRCCALTRY DAHKMSHDAF
410 420 430 440 450
TVIKNCNTSG IQTEWSPPLT MLFLCATKFS ASAPSSSTDI TSFLSSDPSS
460 470 480 490 500
LPKVPVTSSE AKTQGSGPAV TATKKATTSL ESFFQKAAER QKVKEASLSS
510 520 530 540 550
LTAPTQAPMS NSPSKPSLPF QTSQSTGTEP FFKQKSLLLK QKQLNNSSVS
560 570 580 590 600
SPQQNPWSNC KALPNSLPTE YPGCVPVCEG VSKLEESSKA TPAEMDLAHN
610 620 630 640 650
SQSMHASSAS KSVLEVTQKA TPNPSLLAAE DQVPCEKCGS LVPVWDMPEH
660 670 680 690 700
MDYHFALELQ KSFLQPHSSN PQVVSAVSHQ GKRNPKSPLA CTNKRPRPEG
710
MQTLESFFKP LTH
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketQ5JTF2 | Q5JTF2_HUMAN | DNA polymerase eta | POLH | 71 | Annotation score: |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_070835 | 37 | Missing in XPV. 1 Publication | 1 | |
Natural variantiVAR_021226 | 75 | Missing in XPV; impairs translesion synthesis. 2 Publications | 1 | |
Natural variantiVAR_070836 | 93 | R → P in XPV. 1 PublicationCorresponds to variant dbSNP:rs756931657Ensembl. | 1 | |
Natural variantiVAR_021227 | 111 | R → H in XPV. Corresponds to variant dbSNP:rs758423288Ensembl. | 1 | |
Natural variantiVAR_021228 | 122 | T → P in XPV. 1 PublicationCorresponds to variant dbSNP:rs1561900151Ensembl. | 1 | |
Natural variantiVAR_036220 | 153 | G → D in a breast cancer sample; somatic mutation. 1 PublicationCorresponds to variant dbSNP:rs367709714Ensembl. | 1 | |
Natural variantiVAR_021229 | 209 | G → V1 PublicationCorresponds to variant dbSNP:rs2307456EnsemblClinVar. | 1 | |
Natural variantiVAR_021230 | 263 | G → V in XPV; impairs translesion synthesis. 1 PublicationCorresponds to variant dbSNP:rs1413703153Ensembl. | 1 | |
Natural variantiVAR_070837 | 266 | V → D in XPV. 1 Publication | 1 | |
Natural variantiVAR_070838 | 295 | G → R in XPV. 1 Publication | 1 | |
Natural variantiVAR_021231 | 334 | R → W1 PublicationCorresponds to variant dbSNP:rs9333548Ensembl. | 1 | |
Natural variantiVAR_021232 | 361 | R → S in XPV. 1 Publication | 1 | |
Natural variantiVAR_021233 | 478 | T → M1 PublicationCorresponds to variant dbSNP:rs9296419EnsemblClinVar. | 1 | |
Natural variantiVAR_021234 | 535 | K → E in XPV. 1 PublicationCorresponds to variant dbSNP:rs56307355EnsemblClinVar. | 1 | |
Natural variantiVAR_021235 | 584 | L → P1 PublicationCorresponds to variant dbSNP:rs9333554EnsemblClinVar. | 1 | |
Natural variantiVAR_021236 | 589 | K → T in XPV. 1 PublicationCorresponds to variant dbSNP:rs121908565EnsemblClinVar. | 1 | |
Natural variantiVAR_021237 | 595 | M → V1 PublicationCorresponds to variant dbSNP:rs9333555EnsemblClinVar. | 1 | |
Natural variantiVAR_021238 | 647 | M → L1 PublicationCorresponds to variant dbSNP:rs6941583EnsemblClinVar. | 1 | |
Natural variantiVAR_070839 | 692 | T → A in XPV. 1 PublicationCorresponds to variant dbSNP:rs199562456Ensembl. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_012799 | 415 – 713 | Missing in isoform 2. 1 PublicationAdd BLAST | 299 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AB024313 mRNA Translation: BAA81666.1 AF158185 mRNA Translation: AAD43810.1 AB038008 Genomic DNA Translation: BAB18601.1 AY388614 Genomic DNA Translation: AAQ81300.1 AL353602 Genomic DNA No translation available. AL355802 Genomic DNA No translation available. BC015742 mRNA Translation: AAH15742.1 |
CCDSi | CCDS4902.1 [Q9Y253-1] CCDS78147.1 [Q9Y253-2] |
RefSeqi | NP_001278899.1, NM_001291970.1 [Q9Y253-2] NP_006493.1, NM_006502.2 [Q9Y253-1] |
Genome annotation databases
Ensembli | ENST00000372226; ENSP00000361300; ENSG00000170734 [Q9Y253-2] ENST00000372236; ENSP00000361310; ENSG00000170734 [Q9Y253-1] |
GeneIDi | 5429 |
KEGGi | hsa:5429 |
UCSCi | uc003ovq.5, human [Q9Y253-1] |
Keywords - Coding sequence diversityi
Alternative splicing, PolymorphismSimilar proteinsi
Cross-referencesi
Web resourcesi
Atlas of Genetics and Cytogenetics in Oncology and Haematology |
NIEHS-SNPs |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AB024313 mRNA Translation: BAA81666.1 AF158185 mRNA Translation: AAD43810.1 AB038008 Genomic DNA Translation: BAB18601.1 AY388614 Genomic DNA Translation: AAQ81300.1 AL353602 Genomic DNA No translation available. AL355802 Genomic DNA No translation available. BC015742 mRNA Translation: AAH15742.1 |
CCDSi | CCDS4902.1 [Q9Y253-1] CCDS78147.1 [Q9Y253-2] |
RefSeqi | NP_001278899.1, NM_001291970.1 [Q9Y253-2] NP_006493.1, NM_006502.2 [Q9Y253-1] |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
2I5O | NMR | - | A | 628-662 | [»] | |
2LSK | NMR | - | B | 524-539 | [»] | |
3JAA | electron microscopy | 22.00 | A | 1-432 | [»] | |
3MR2 | X-ray | 1.83 | A | 1-432 | [»] | |
3MR3 | X-ray | 1.75 | A | 1-432 | [»] | |
3MR5 | X-ray | 1.80 | A | 1-432 | [»] | |
3MR6 | X-ray | 1.90 | A | 1-432 | [»] | |
3SI8 | X-ray | 2.15 | A | 1-432 | [»] | |
3TQ1 | X-ray | 2.56 | A | 1-432 | [»] | |
3WUP | X-ray | 1.60 | A | 630-665 | [»] | |
4DL2 | X-ray | 2.15 | A | 1-432 | [»] | |
4DL3 | X-ray | 2.10 | A | 1-432 | [»] | |
4DL4 | X-ray | 2.00 | A | 1-432 | [»] | |
4DL5 | X-ray | 2.92 | A | 1-432 | [»] | |
4DL6 | X-ray | 2.50 | A | 1-432 | [»] | |
4DL7 | X-ray | 1.97 | A | 1-432 | [»] | |
4ECQ | X-ray | 1.50 | A | 1-432 | [»] | |
4ECR | X-ray | 1.89 | A | 1-432 | [»] | |
4ECS | X-ray | 1.95 | A | 1-432 | [»] | |
4ECT | X-ray | 1.80 | A | 1-432 | [»] | |
4ECU | X-ray | 1.95 | A | 1-432 | [»] | |
4ECV | X-ray | 1.52 | A | 1-432 | [»] | |
4ECW | X-ray | 1.90 | A | 1-432 | [»] | |
4ECX | X-ray | 1.74 | A | 1-432 | [»] | |
4ECY | X-ray | 1.94 | A | 1-432 | [»] | |
4ECZ | X-ray | 1.83 | A | 1-432 | [»] | |
4ED0 | X-ray | 1.65 | A | 1-432 | [»] | |
4ED1 | X-ray | 1.81 | A | 1-432 | [»] | |
4ED2 | X-ray | 1.71 | A | 1-432 | [»] | |
4ED3 | X-ray | 1.79 | A | 1-432 | [»] | |
4ED6 | X-ray | 2.21 | A | 1-432 | [»] | |
4ED7 | X-ray | 1.72 | A | 1-432 | [»] | |
4ED8 | X-ray | 1.52 | A | 1-432 | [»] | |
4EEY | X-ray | 2.32 | A | 1-432 | [»] | |
4J9K | X-ray | 2.03 | A | 1-432 | [»] | |
4J9L | X-ray | 1.85 | A | 1-432 | [»] | |
4J9M | X-ray | 2.25 | A | 1-432 | [»] | |
4J9N | X-ray | 1.96 | A | 1-432 | [»] | |
4J9O | X-ray | 2.60 | A | 1-432 | [»] | |
4J9P | X-ray | 2.30 | A | 1-432 | [»] | |
4J9Q | X-ray | 1.96 | A | 1-432 | [»] | |
4J9R | X-ray | 2.35 | A | 1-432 | [»] | |
4J9S | X-ray | 1.95 | A | 1-432 | [»] | |
4O3N | X-ray | 1.58 | A | 1-432 | [»] | |
4O3O | X-ray | 1.70 | A | 1-432 | [»] | |
4O3P | X-ray | 1.72 | A | 1-432 | [»] | |
4O3Q | X-ray | 1.72 | A | 1-432 | [»] | |
4O3R | X-ray | 1.62 | A | 1-432 | [»] | |
4O3S | X-ray | 1.72 | A | 1-432 | [»] | |
4Q8E | X-ray | 1.55 | A | 1-432 | [»] | |
4Q8F | X-ray | 2.80 | A | 1-432 | [»] | |
4RNM | X-ray | 2.14 | A | 1-432 | [»] | |
4RNN | X-ray | 1.81 | A | 1-432 | [»] | |
4RNO | X-ray | 2.82 | A | 1-432 | [»] | |
4RU9 | X-ray | 2.65 | A | 1-432 | [»] | |
4YP3 | X-ray | 1.89 | A | 1-432 | [»] | |
4YQW | X-ray | 2.06 | A | 1-432 | [»] | |
4YR0 | X-ray | 1.78 | A | 1-432 | [»] | |
4YR2 | X-ray | 1.95 | A | 1-432 | [»] | |
4YR3 | X-ray | 2.00 | A | 1-432 | [»] | |
5DG7 | X-ray | 2.26 | A | 1-432 | [»] | |
5DG8 | X-ray | 2.12 | A | 1-432 | [»] | |
5DG9 | X-ray | 2.15 | A | 1-432 | [»] | |
5DGA | X-ray | 2.30 | A | 1-432 | [»] | |
5DGB | X-ray | 1.79 | A | 1-432 | [»] | |
5DLF | X-ray | 1.97 | A | 1-432 | [»] | |
5DLG | X-ray | 2.35 | A | 1-432 | [»] | |
5DQG | X-ray | 2.29 | A | 1-432 | [»] | |
5DQH | X-ray | 1.99 | A | 1-432 | [»] | |
5DQI | X-ray | 2.30 | A | 1-432 | [»] | |
5EWE | X-ray | 1.66 | A | 1-432 | [»] | |
5EWF | X-ray | 1.78 | A | 1-432 | [»] | |
5EWG | X-ray | 1.75 | A | 1-432 | [»] | |
5F9L | X-ray | 2.59 | A | 1-432 | [»] | |
5F9N | X-ray | 2.23 | A | 1-432 | [»] | |
5JUM | X-ray | 2.60 | A | 1-432 | [»] | |
5KFA | X-ray | 1.51 | A | 1-432 | [»] | |
5KFB | X-ray | 1.55 | A | 1-432 | [»] | |
5KFC | X-ray | 1.50 | A | 1-432 | [»] | |
5KFD | X-ray | 1.65 | A | 1-432 | [»] | |
5KFE | X-ray | 1.55 | A | 1-432 | [»] | |
5KFF | X-ray | 1.70 | A | 1-432 | [»] | |
5KFG | X-ray | 1.55 | A | 1-432 | [»] | |
5KFH | X-ray | 1.72 | A | 1-432 | [»] | |
5KFI | X-ray | 1.65 | A | 1-432 | [»] | |
5KFJ | X-ray | 1.70 | A | 1-432 | [»] | |
5KFK | X-ray | 1.70 | A | 1-432 | [»] | |
5KFL | X-ray | 1.65 | A | 1-432 | [»] | |
5KFM | X-ray | 1.60 | A | 1-432 | [»] | |
5KFN | X-ray | 1.45 | A | 1-432 | [»] | |
5KFO | X-ray | 1.52 | A | 1-432 | [»] | |
5KFP | X-ray | 1.70 | A | 1-432 | [»] | |
5KFQ | X-ray | 1.55 | A | 1-432 | [»] | |
5KFR | X-ray | 1.75 | A | 1-432 | [»] | |
5KFS | X-ray | 1.46 | A | 1-432 | [»] | |
5KFT | X-ray | 1.52 | A | 1-432 | [»] | |
5KFU | X-ray | 1.55 | A | 1-432 | [»] | |
5KFV | X-ray | 1.60 | A | 1-432 | [»] | |
5KFW | X-ray | 1.62 | A | 1-432 | [»] | |
5KFX | X-ray | 1.52 | A | 1-432 | [»] | |
5KFY | X-ray | 1.70 | A | 1-432 | [»] | |
5KFZ | X-ray | 1.44 | A | 1-432 | [»] | |
5KG0 | X-ray | 1.60 | A | 1-432 | [»] | |
5KG1 | X-ray | 1.62 | A | 1-432 | [»] | |
5KG2 | X-ray | 1.60 | A | 1-432 | [»] | |
5KG3 | X-ray | 1.70 | A | 1-432 | [»] | |
5KG4 | X-ray | 1.60 | A | 1-432 | [»] | |
5KG5 | X-ray | 1.60 | A | 1-432 | [»] | |
5KG6 | X-ray | 1.55 | A | 1-432 | [»] | |
5KG7 | X-ray | 1.75 | A | 1-432 | [»] | |
5L1I | X-ray | 2.78 | A | 1-432 | [»] | |
5L1J | X-ray | 1.94 | A | 1-432 | [»] | |
5L1K | X-ray | 1.82 | A | 1-432 | [»] | |
5L1L | X-ray | 1.62 | A | 1-432 | [»] | |
5L9X | X-ray | 1.90 | A | 1-432 | [»] | |
6D0M | X-ray | 1.83 | A | 1-432 | [»] | |
6D0Z | X-ray | 1.75 | A | 1-432 | [»] | |
6M7O | X-ray | 3.00 | A | 1-432 | [»] | |
6M7P | X-ray | 1.75 | A | 1-432 | [»] | |
6M7T | X-ray | 2.80 | A | 1-432 | [»] | |
6M7U | X-ray | 3.40 | A | 1-432 | [»] | |
6M7V | X-ray | 3.06 | A | 1-432 | [»] | |
6MP3 | X-ray | 1.91 | A | 1-432 | [»] | |
6MQ8 | X-ray | 1.97 | A | 3-432 | [»] | |
6MXO | X-ray | 2.04 | A | 3-435 | [»] | |
6PL7 | X-ray | 2.50 | A | 1-432 | [»] | |
6PL8 | X-ray | 2.17 | A | 1-432 | [»] | |
6PLC | X-ray | 2.50 | A | 1-432 | [»] | |
6PZ3 | X-ray | 2.40 | A | 1-432 | [»] | |
6Q02 | X-ray | 2.09 | A | 1-432 | [»] | |
6UI2 | X-ray | 2.35 | A | 1-432 | [»] | |
BMRBi | Q9Y253 | |||||
SMRi | Q9Y253 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 111425, 44 interactors |
CORUMi | Q9Y253 |
IntActi | Q9Y253, 23 interactors |
MINTi | Q9Y253 |
STRINGi | 9606.ENSP00000361310 |
Chemistry databases
BindingDBi | Q9Y253 |
ChEMBLi | CHEMBL5542 |
PTM databases
iPTMneti | Q9Y253 |
PhosphoSitePlusi | Q9Y253 |
Polymorphism and mutation databases
BioMutai | POLH |
DMDMi | 59798441 |
Proteomic databases
EPDi | Q9Y253 |
jPOSTi | Q9Y253 |
MassIVEi | Q9Y253 |
PaxDbi | Q9Y253 |
PeptideAtlasi | Q9Y253 |
PRIDEi | Q9Y253 |
ProteomicsDBi | 85655 [Q9Y253-1] 85656 [Q9Y253-2] |
Protocols and materials databases
Antibodypediai | 1879, 191 antibodies |
Genome annotation databases
Ensembli | ENST00000372226; ENSP00000361300; ENSG00000170734 [Q9Y253-2] ENST00000372236; ENSP00000361310; ENSG00000170734 [Q9Y253-1] |
GeneIDi | 5429 |
KEGGi | hsa:5429 |
UCSCi | uc003ovq.5, human [Q9Y253-1] |
Organism-specific databases
CTDi | 5429 |
DisGeNETi | 5429 |
EuPathDBi | HostDB:ENSG00000170734.11 |
GeneCardsi | POLH |
GeneReviewsi | POLH |
HGNCi | HGNC:9181, POLH |
HPAi | ENSG00000170734, Low tissue specificity |
MalaCardsi | POLH |
MIMi | 278750, phenotype 603968, gene |
neXtProti | NX_Q9Y253 |
OpenTargetsi | ENSG00000170734 |
Orphaneti | 90342, Xeroderma pigmentosum variant |
PharmGKBi | PA279 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG2095, Eukaryota |
GeneTreei | ENSGT00940000157048 |
HOGENOMi | CLU_012348_7_2_1 |
InParanoidi | Q9Y253 |
OMAi | DYHFAME |
OrthoDBi | 20162at2759 |
PhylomeDBi | Q9Y253 |
TreeFami | TF103010 |
Enzyme and pathway databases
BRENDAi | 2.7.7.7, 2681 |
PathwayCommonsi | Q9Y253 |
Reactomei | R-HSA-110320, Translesion Synthesis by POLH R-HSA-5656169, Termination of translesion DNA synthesis R-HSA-5685942, HDR through Homologous Recombination (HRR) |
SABIO-RKi | Q9Y253 |
SIGNORi | Q9Y253 |
Miscellaneous databases
BioGRID-ORCSi | 5429, 9 hits in 848 CRISPR screens |
ChiTaRSi | POLH, human |
EvolutionaryTracei | Q9Y253 |
GeneWikii | DNA_polymerase_eta |
GenomeRNAii | 5429 |
Pharosi | Q9Y253, Tbio |
PROi | PR:Q9Y253 |
RNActi | Q9Y253, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000170734, Expressed in buccal mucosa cell and 247 other tissues |
ExpressionAtlasi | Q9Y253, baseline and differential |
Genevisiblei | Q9Y253, HS |
Family and domain databases
Gene3Di | 3.30.1490.100, 1 hit 3.30.70.270, 1 hit |
IDEALi | IID00108 |
InterProi | View protein in InterPro IPR043502, DNA/RNA_pol_sf IPR036775, DNA_pol_Y-fam_lit_finger_sf IPR017961, DNA_pol_Y-fam_little_finger IPR043128, Rev_trsase/Diguanyl_cyclase IPR041298, UBZ3 IPR001126, UmuC |
Pfami | View protein in Pfam PF00817, IMS, 1 hit PF11799, IMS_C, 1 hit PF18439, zf_UBZ, 1 hit |
SUPFAMi | SSF100879, SSF100879, 1 hit SSF56672, SSF56672, 1 hit |
PROSITEi | View protein in PROSITE PS50173, UMUC, 1 hit PS51907, ZF_UBZ3, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | POLH_HUMAN | |
Accessioni | Q9Y253Primary (citable) accession number: Q9Y253 Secondary accession number(s): Q7L8E3, Q96BC4, Q9BX13 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | February 15, 2005 |
Last sequence update: | November 1, 1999 | |
Last modified: | December 2, 2020 | |
This is version 177 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Direct protein sequencing, Reference proteomeDocuments
- Human chromosome 6
Human chromosome 6: entries, gene names and cross-references to MIM - Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families - Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations