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Entry version 154 (18 Sep 2019)
Sequence version 1 (01 Nov 1999)
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Protein

E3 ubiquitin-protein ligase RNF6

Gene

RNF6

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

E3 ubiquitin-protein ligase mediating 'Lys-48'-linked polyubiquitination of LIMK1 and its subsequent targeting to the proteasome for degradation. Negatively regulates axonal outgrowth through regulation of the LIMK1 turnover. Mediates 'Lys-6' and 'Lys-27'-linked polyubiquitination of AR/androgen receptor thereby modulating its transcriptional activity. May also bind DNA and function as a transcriptional regulator.1 Publication

Miscellaneous

Required for prostate tumor cell growth.

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

  • S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine. EC:2.3.2.27

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section describes the metabolic pathway(s) associated with a protein.<p><a href='/help/pathway' target='_top'>More...</a></p>Pathwayi: protein ubiquitination

This protein is involved in the pathway protein ubiquitination, which is part of Protein modification.
View all proteins of this organism that are known to be involved in the pathway protein ubiquitination and in Protein modification.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section specifies the position(s) and type(s) of zinc fingers within the protein.<p><a href='/help/zn_fing' target='_top'>More...</a></p>Zinc fingeri632 – 673RING-typePROSITE-ProRule annotationAdd BLAST42

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionTransferase
Biological processUbl conjugation pathway
LigandMetal-binding, Zinc

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-983168 Antigen processing: Ubiquitination & Proteasome degradation

UniPathway: a resource for the exploration and annotation of metabolic pathways

More...
UniPathwayi
UPA00143

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
E3 ubiquitin-protein ligase RNF6 (EC:2.3.2.27)
Alternative name(s):
RING-type E3 ubiquitin transferase RNF6Curated
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:RNF6
Synonyms:SPG2
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 13

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:10069 RNF6

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
604242 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q9Y252

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell projection, Cytoplasm, Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Esophageal cancer (ESCR)1 Publication
The disease may be caused by mutations affecting the gene represented in this entry.
Disease descriptionA malignancy of the esophagus. The most common types are esophageal squamous cell carcinoma and adenocarcinoma. Cancer of the esophagus remains a devastating disease because it is usually not detected until it has progressed to an advanced incurable stage.
Related information in OMIM

Organism-specific databases

DisGeNET

More...
DisGeNETi
6049

MalaCards human disease database

More...
MalaCardsi
RNF6
MIMi133239 phenotype

Open Targets

More...
OpenTargetsi
ENSG00000127870

Orphanet; a database dedicated to information on rare diseases and orphan drugs

More...
Orphaneti
99977 Squamous cell carcinoma of the esophagus

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA34443

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
RNF6

Domain mapping of disease mutations (DMDM)

More...
DMDMi
13124536

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000560471 – 685E3 ubiquitin-protein ligase RNF6Add BLAST685

Proteomic databases

Encyclopedia of Proteome Dynamics

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EPDi
Q9Y252

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q9Y252

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
Q9Y252

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q9Y252

PeptideAtlas

More...
PeptideAtlasi
Q9Y252

PRoteomics IDEntifications database

More...
PRIDEi
Q9Y252

ProteomicsDB human proteome resource

More...
ProteomicsDBi
85654 [Q9Y252-1]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q9Y252

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

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PhosphoSitePlusi
Q9Y252

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Weakly expressed in peripheral blood, spleen, prostate, testis and ovary. According to PubMed:18368307, it is preferentially expressed in testis and ovary and hardly detected in other tissues.2 Publications

<p>This subsection of the ‘Expression’ section provides information on the expression of the gene product at various stages of a cell, tissue or organism development. By default, the information is derived from experiments at the mRNA level, unless specified ‘at the protein level’.<p><a href='/help/developmental_stage' target='_top'>More...</a></p>Developmental stagei

Expressed in embryo and adult testis.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000127870 Expressed in 235 organ(s), highest expression level in caudate nucleus

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
Q9Y252 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
Q9Y252 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA039343
HPA040048

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with LIMK1 (By similarity).

Interacts with AR.

By similarity1 Publication

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

WithEntry#Exp.IntActNotes
ARP1027510EBI-2341483,EBI-608057

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
111976, 63 interactors

Protein interaction database and analysis system

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IntActi
Q9Y252, 7 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000371000

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
Q9Y252

Database of comparative protein structure models

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ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni607 – 685Required for polyubiquitinationBy similarityAdd BLAST79

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi292 – 424Arg-richAdd BLAST133
Compositional biasi598 – 601Poly-Asp4

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the RNF12 family.Curated

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri632 – 673RING-typePROSITE-ProRule annotationAdd BLAST42

Keywords - Domaini

Zinc-finger

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG0800 Eukaryota
ENOG41121N2 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000158530

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000273881

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q9Y252

KEGG Orthology (KO)

More...
KOi
K22753

Identification of Orthologs from Complete Genome Data

More...
OMAi
HVWENGA

Database of Orthologous Groups

More...
OrthoDBi
1487241at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q9Y252

TreeFam database of animal gene trees

More...
TreeFami
TF325756

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
3.30.40.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR001841 Znf_RING
IPR013083 Znf_RING/FYVE/PHD

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF13639 zf-RING_2, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00184 RING, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50089 ZF_RING_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 3 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
Isoform 1 (identifier: Q9Y252-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MNQSRSRSDG GSEETLPQDH NHHENERRWQ QERLHREEAY YQFINELNDE
60 70 80 90 100
DYRLMRDHNL LGTPGEITSE ELQQRLDGVK EQLASQPDLR DGTNYRDSEV
110 120 130 140 150
PRESSHEDSL LEWLNTFRRT GNATRSGQNG NQTWRAVSRT NPNNGEFRFS
160 170 180 190 200
LEIHVNHENR GFEIHGEDYT DIPLSDSNRD HTANRQQRST SPVARRTRSQ
210 220 230 240 250
TSVNFNGSSS NIPRTRLASR GQNPAEGSFS TLGRLRNGIG GAAGIPRANA
260 270 280 290 300
SRTNFSSHTN QSGGSELRQR EGQRFGAAHV WENGARSNVT VRNTNQRLEP
310 320 330 340 350
IRLRSTSNSR SRSPIQRQSG TVYHNSQRES RPVQQTTRRS VRRRGRTRVF
360 370 380 390 400
LEQDRERERR GTAYTPFSNS RLVSRITVEE GEESSRSSTA VRRHPTITLD
410 420 430 440 450
LQVRRIRPGE NRDRDSIANR TRSRVGLAEN TVTIESNSGG FRRTISRLER
460 470 480 490 500
SGIRTYVSTI TVPLRRISEN ELVEPSSVAL RSILRQIMTG FGELSSLMEA
510 520 530 540 550
DSESELQRNG QHLPDMHSEL SNLGTDNNRS QHREGSSQDR QAQGDSTEMH
560 570 580 590 600
GENETTQPHT RNSDSRGGRQ LRNPNNLVET GTLPILRLAH FFLLNESDDD
610 620 630 640 650
DRIRGLTKEQ IDNLSTRHYE HNSIDSELGK ICSVCISDYV TGNKLRQLPC
660 670 680
MHEFHIHCID RWLSENCTCP ICRQPVLGSN IANNG
Length:685
Mass (Da):78,091
Last modified:November 1, 1999 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i344584773F2E5EFC
GO
Isoform 2 (identifier: Q9Y252-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-15: MNQSRSRSDGGSEET → MQLEVDKMGTKLGEL
     16-371: Missing.

Note: No experimental confirmation available.
Show »
Length:329
Mass (Da):37,094
Checksum:i03CCF8BF21E456F6
GO
Isoform 3 (identifier: Q9Y252-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     137-142: VSRTNP → ALPDTS
     143-685: Missing.

Show »
Length:142
Mass (Da):16,680
Checksum:i6ED5C036833DD1DD
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_03446548N → S1 PublicationCorresponds to variant dbSNP:rs3910433Ensembl.1
Natural variantiVAR_063490102R → K Found in an esophageal cancer sample; esophageal squamous cell carcinoma; somatic mutation. 1 PublicationCorresponds to variant dbSNP:rs121434522EnsemblClinVar.1
Natural variantiVAR_063491164I → T1 PublicationCorresponds to variant dbSNP:rs61760897Ensembl.1
Natural variantiVAR_052094203V → E. Corresponds to variant dbSNP:rs7990167Ensembl.1
Natural variantiVAR_063492242A → T Found in an esophageal cancer sample; esophageal squamous cell carcinoma; somatic mutation. 1 PublicationCorresponds to variant dbSNP:rs121434523EnsemblClinVar.1
Natural variantiVAR_063493244G → D Found in an esophageal cancer sample; esophageal squamous cell carcinoma; somatic mutation. 1 PublicationCorresponds to variant dbSNP:rs121434524EnsemblClinVar.1
Natural variantiVAR_063494572R → Q1 PublicationCorresponds to variant dbSNP:rs138379662Ensembl.1
Natural variantiVAR_052095623S → N1 PublicationCorresponds to variant dbSNP:rs17083436Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0554241 – 15MNQSR…GSEET → MQLEVDKMGTKLGEL in isoform 2. 1 PublicationAdd BLAST15
Alternative sequenceiVSP_05542516 – 371Missing in isoform 2. 1 PublicationAdd BLAST356
Alternative sequenceiVSP_055426137 – 142VSRTNP → ALPDTS in isoform 3. 1 Publication6
Alternative sequenceiVSP_055427143 – 685Missing in isoform 3. 1 PublicationAdd BLAST543

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AJ010347 mRNA Translation: CAB40414.1
AJ010346 mRNA Translation: CAB40413.1
AF293342 mRNA Translation: AAK00848.1
AY009109 mRNA Translation: AAG49400.1
AK293272 mRNA Translation: BAG56801.1
AK312435 mRNA Translation: BAG35344.1
AL138966 Genomic DNA No translation available.
CH471075 Genomic DNA Translation: EAX08380.1
BC034688 mRNA Translation: AAH34688.1
AL133621 mRNA Translation: CAB63747.1

The Consensus CDS (CCDS) project

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CCDSi
CCDS9316.1 [Q9Y252-1]

Protein sequence database of the Protein Information Resource

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PIRi
T43459

NCBI Reference Sequences

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RefSeqi
NP_005968.1, NM_005977.3 [Q9Y252-1]
NP_898864.1, NM_183043.2 [Q9Y252-1]
NP_898865.1, NM_183044.2 [Q9Y252-1]
NP_898866.1, NM_183045.1 [Q9Y252-3]
XP_005266542.1, XM_005266485.2 [Q9Y252-1]
XP_005266543.1, XM_005266486.2 [Q9Y252-1]
XP_011533479.1, XM_011535177.2 [Q9Y252-1]
XP_011533480.1, XM_011535178.1 [Q9Y252-3]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000346166; ENSP00000342121; ENSG00000127870 [Q9Y252-1]
ENST00000381570; ENSP00000370982; ENSG00000127870 [Q9Y252-1]
ENST00000381588; ENSP00000371000; ENSG00000127870 [Q9Y252-1]

Database of genes from NCBI RefSeq genomes

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GeneIDi
6049

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:6049

UCSC genome browser

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UCSCi
uc001uqo.4 human [Q9Y252-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ010347 mRNA Translation: CAB40414.1
AJ010346 mRNA Translation: CAB40413.1
AF293342 mRNA Translation: AAK00848.1
AY009109 mRNA Translation: AAG49400.1
AK293272 mRNA Translation: BAG56801.1
AK312435 mRNA Translation: BAG35344.1
AL138966 Genomic DNA No translation available.
CH471075 Genomic DNA Translation: EAX08380.1
BC034688 mRNA Translation: AAH34688.1
AL133621 mRNA Translation: CAB63747.1
CCDSiCCDS9316.1 [Q9Y252-1]
PIRiT43459
RefSeqiNP_005968.1, NM_005977.3 [Q9Y252-1]
NP_898864.1, NM_183043.2 [Q9Y252-1]
NP_898865.1, NM_183044.2 [Q9Y252-1]
NP_898866.1, NM_183045.1 [Q9Y252-3]
XP_005266542.1, XM_005266485.2 [Q9Y252-1]
XP_005266543.1, XM_005266486.2 [Q9Y252-1]
XP_011533479.1, XM_011535177.2 [Q9Y252-1]
XP_011533480.1, XM_011535178.1 [Q9Y252-3]

3D structure databases

SMRiQ9Y252
ModBaseiSearch...

Protein-protein interaction databases

BioGridi111976, 63 interactors
IntActiQ9Y252, 7 interactors
STRINGi9606.ENSP00000371000

PTM databases

iPTMnetiQ9Y252
PhosphoSitePlusiQ9Y252

Polymorphism and mutation databases

BioMutaiRNF6
DMDMi13124536

Proteomic databases

EPDiQ9Y252
jPOSTiQ9Y252
MassIVEiQ9Y252
PaxDbiQ9Y252
PeptideAtlasiQ9Y252
PRIDEiQ9Y252
ProteomicsDBi85654 [Q9Y252-1]

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
6049
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000346166; ENSP00000342121; ENSG00000127870 [Q9Y252-1]
ENST00000381570; ENSP00000370982; ENSG00000127870 [Q9Y252-1]
ENST00000381588; ENSP00000371000; ENSG00000127870 [Q9Y252-1]
GeneIDi6049
KEGGihsa:6049
UCSCiuc001uqo.4 human [Q9Y252-1]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
6049
DisGeNETi6049

GeneCards: human genes, protein and diseases

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GeneCardsi
RNF6
HGNCiHGNC:10069 RNF6
HPAiHPA039343
HPA040048
MalaCardsiRNF6
MIMi133239 phenotype
604242 gene
neXtProtiNX_Q9Y252
OpenTargetsiENSG00000127870
Orphaneti99977 Squamous cell carcinoma of the esophagus
PharmGKBiPA34443

GenAtlas: human gene database

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GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG0800 Eukaryota
ENOG41121N2 LUCA
GeneTreeiENSGT00940000158530
HOGENOMiHOG000273881
InParanoidiQ9Y252
KOiK22753
OMAiHVWENGA
OrthoDBi1487241at2759
PhylomeDBiQ9Y252
TreeFamiTF325756

Enzyme and pathway databases

UniPathwayiUPA00143
ReactomeiR-HSA-983168 Antigen processing: Ubiquitination & Proteasome degradation

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
RNF6 human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
6049

Pharos

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Pharosi
Q9Y252

Protein Ontology

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PROi
PR:Q9Y252

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
Search...

Gene expression databases

BgeeiENSG00000127870 Expressed in 235 organ(s), highest expression level in caudate nucleus
ExpressionAtlasiQ9Y252 baseline and differential
GenevisibleiQ9Y252 HS

Family and domain databases

Gene3Di3.30.40.10, 1 hit
InterProiView protein in InterPro
IPR001841 Znf_RING
IPR013083 Znf_RING/FYVE/PHD
PfamiView protein in Pfam
PF13639 zf-RING_2, 1 hit
SMARTiView protein in SMART
SM00184 RING, 1 hit
PROSITEiView protein in PROSITE
PS50089 ZF_RING_2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiRNF6_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9Y252
Secondary accession number(s): B4DDP0
, Q5W0H0, Q9BZP5, Q9UF41
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 21, 2001
Last sequence update: November 1, 1999
Last modified: September 18, 2019
This is version 154 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 13
    Human chromosome 13: entries, gene names and cross-references to MIM
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  6. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
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