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Protein

DNA replication complex GINS protein PSF2

Gene

GINS2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

The GINS complex plays an essential role in the initiation of DNA replication, and progression of DNA replication forks. GINS complex seems to bind preferentially to single-stranded DNA.1 Publication

GO - Biological processi

Keywordsi

Biological processDNA replication

Enzyme and pathway databases

ReactomeiR-HSA-176974 Unwinding of DNA

Names & Taxonomyi

Protein namesi
Recommended name:
DNA replication complex GINS protein PSF2
Alternative name(s):
GINS complex subunit 2
Gene namesi
Name:GINS2
Synonyms:PSF2
ORF Names:CGI-122, DC5, HSPC037
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 16

Organism-specific databases

EuPathDBiHostDB:ENSG00000131153.8
HGNCiHGNC:24575 GINS2
MIMi610609 gene
neXtProtiNX_Q9Y248

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi51659
OpenTargetsiENSG00000131153
PharmGKBiPA145008313

Polymorphism and mutation databases

BioMutaiGINS2
DMDMi37999822

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001948131 – 185DNA replication complex GINS protein PSF2Add BLAST185

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1N-acetylmethionineCombined sources1
Cross-linki109Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei180PhosphothreonineCombined sources1
Modified residuei182PhosphoserineCombined sources1

Keywords - PTMi

Acetylation, Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDiQ9Y248
MaxQBiQ9Y248
PaxDbiQ9Y248
PeptideAtlasiQ9Y248
PRIDEiQ9Y248
ProteomicsDBi85645

PTM databases

iPTMnetiQ9Y248
PhosphoSitePlusiQ9Y248
SwissPalmiQ9Y248

Expressioni

Gene expression databases

BgeeiENSG00000131153 Expressed in 155 organ(s), highest expression level in oocyte
CleanExiHS_GINS2
ExpressionAtlasiQ9Y248 baseline and differential
GenevisibleiQ9Y248 HS

Organism-specific databases

HPAiHPA057285

Interactioni

Subunit structurei

Component of the GINS complex which is a heterotetramer of GINS1, GINS2, GINS3 and GINS4. Forms a stable subcomplex with GINS3. GINS complex interacts with DNA primase in vitro.4 Publications

Binary interactionsi

Protein-protein interaction databases

BioGridi119664, 36 interactors
CORUMiQ9Y248
DIPiDIP-29332N
IntActiQ9Y248, 5 interactors
MINTiQ9Y248
STRINGi9606.ENSP00000253462

Structurei

Secondary structure

1185
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliQ9Y248
SMRiQ9Y248
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ9Y248

Family & Domainsi

Sequence similaritiesi

Belongs to the GINS2/PSF2 family.Curated

Phylogenomic databases

eggNOGiKOG4071 Eukaryota
COG5093 LUCA
GeneTreeiENSGT00390000007838
HOGENOMiHOG000246603
HOVERGENiHBG044983
InParanoidiQ9Y248
KOiK10733
OMAiIRMSKLR
OrthoDBiEOG091G0NTM
PhylomeDBiQ9Y248
TreeFamiTF314359

Family and domain databases

InterProiView protein in InterPro
IPR021151 GINS_A
IPR036224 GINS_bundle-like_dom_sf
IPR007257 GINS_Psf2
PANTHERiPTHR12772 PTHR12772, 1 hit
PfamiView protein in Pfam
PF05916 Sld5, 1 hit
PIRSFiPIRSF028998 GINS_Psf2_subgr, 1 hit
SUPFAMiSSF158573 SSF158573, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

Q9Y248-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MDAAEVEFLA EKELVTIIPN FSLDKIYLIG GDLGPFNPGL PVEVPLWLAI
60 70 80 90 100
NLKQRQKCRL LPPEWMDVEK LEKMRDHERK EETFTPMPSP YYMELTKLLL
110 120 130 140 150
NHASDNIPKA DEIRTLVKDM WDTRIAKLRV SADSFVRQQE AHAKLDNLTL
160 170 180
MEINTSGTFL TQALNHMYKL RTNLQPLEST QSQDF
Length:185
Mass (Da):21,428
Last modified:November 1, 1999 - v1
Checksum:i4F6A18B1ED76F93C
GO

Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
M0R043M0R043_HUMAN
DNA replication complex GINS protei...
GINS2
69Annotation score:
M0QXS3M0QXS3_HUMAN
DNA replication complex GINS protei...
GINS2
51Annotation score:

Mass spectrometryi

Molecular mass is 98373±13 Da from positions 1 - 185. Determined by ESI. This is the measured mass for the GINS complex.1 Publication

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF125098 mRNA Translation: AAD39915.1
AF151880 mRNA Translation: AAD34117.1
AF201939 mRNA Translation: AAF86875.1
AK001275 mRNA Translation: BAA91595.1
CR457186 mRNA Translation: CAG33467.1
CH471114 Genomic DNA Translation: EAW95443.1
CH471114 Genomic DNA Translation: EAW95444.1
BC003186 mRNA Translation: AAH03186.1
BC010164 mRNA Translation: AAH10164.1
BC062444 mRNA Translation: AAH62444.1
CCDSiCCDS10953.1
RefSeqiNP_057179.1, NM_016095.2
UniGeneiHs.433180

Genome annotation databases

EnsembliENST00000253462; ENSP00000253462; ENSG00000131153
GeneIDi51659
KEGGihsa:51659
UCSCiuc002fja.4 human

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF125098 mRNA Translation: AAD39915.1
AF151880 mRNA Translation: AAD34117.1
AF201939 mRNA Translation: AAF86875.1
AK001275 mRNA Translation: BAA91595.1
CR457186 mRNA Translation: CAG33467.1
CH471114 Genomic DNA Translation: EAW95443.1
CH471114 Genomic DNA Translation: EAW95444.1
BC003186 mRNA Translation: AAH03186.1
BC010164 mRNA Translation: AAH10164.1
BC062444 mRNA Translation: AAH62444.1
CCDSiCCDS10953.1
RefSeqiNP_057179.1, NM_016095.2
UniGeneiHs.433180

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2E9XX-ray2.30B/F1-185[»]
2EHOX-ray3.00C/G/K1-185[»]
2Q9QX-ray2.36A/E1-185[»]
ProteinModelPortaliQ9Y248
SMRiQ9Y248
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi119664, 36 interactors
CORUMiQ9Y248
DIPiDIP-29332N
IntActiQ9Y248, 5 interactors
MINTiQ9Y248
STRINGi9606.ENSP00000253462

PTM databases

iPTMnetiQ9Y248
PhosphoSitePlusiQ9Y248
SwissPalmiQ9Y248

Polymorphism and mutation databases

BioMutaiGINS2
DMDMi37999822

Proteomic databases

EPDiQ9Y248
MaxQBiQ9Y248
PaxDbiQ9Y248
PeptideAtlasiQ9Y248
PRIDEiQ9Y248
ProteomicsDBi85645

Protocols and materials databases

DNASUi51659
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000253462; ENSP00000253462; ENSG00000131153
GeneIDi51659
KEGGihsa:51659
UCSCiuc002fja.4 human

Organism-specific databases

CTDi51659
DisGeNETi51659
EuPathDBiHostDB:ENSG00000131153.8
GeneCardsiGINS2
HGNCiHGNC:24575 GINS2
HPAiHPA057285
MIMi610609 gene
neXtProtiNX_Q9Y248
OpenTargetsiENSG00000131153
PharmGKBiPA145008313
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG4071 Eukaryota
COG5093 LUCA
GeneTreeiENSGT00390000007838
HOGENOMiHOG000246603
HOVERGENiHBG044983
InParanoidiQ9Y248
KOiK10733
OMAiIRMSKLR
OrthoDBiEOG091G0NTM
PhylomeDBiQ9Y248
TreeFamiTF314359

Enzyme and pathway databases

ReactomeiR-HSA-176974 Unwinding of DNA

Miscellaneous databases

ChiTaRSiGINS2 human
EvolutionaryTraceiQ9Y248
GeneWikiiGINS2
GenomeRNAii51659
PROiPR:Q9Y248
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000131153 Expressed in 155 organ(s), highest expression level in oocyte
CleanExiHS_GINS2
ExpressionAtlasiQ9Y248 baseline and differential
GenevisibleiQ9Y248 HS

Family and domain databases

InterProiView protein in InterPro
IPR021151 GINS_A
IPR036224 GINS_bundle-like_dom_sf
IPR007257 GINS_Psf2
PANTHERiPTHR12772 PTHR12772, 1 hit
PfamiView protein in Pfam
PF05916 Sld5, 1 hit
PIRSFiPIRSF028998 GINS_Psf2_subgr, 1 hit
SUPFAMiSSF158573 SSF158573, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiPSF2_HUMAN
AccessioniPrimary (citable) accession number: Q9Y248
Secondary accession number(s): D3DUM5, Q6IAG9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 24, 2003
Last sequence update: November 1, 1999
Last modified: November 7, 2018
This is version 144 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 16
    Human chromosome 16: entries, gene names and cross-references to MIM
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
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Main funding by: National Institutes of Health

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