UniProtKB - Q9Y247 (FA50B_HUMAN)
Protein
Protein FAM50B
Gene
FAM50B
Organism
Homo sapiens (Human)
Status
Functioni
GO - Biological processi
- chromatin organization Source: GO_Central
Enzyme and pathway databases
PathwayCommonsi | Q9Y247 |
Names & Taxonomyi
Protein namesi | Recommended name: Protein FAM50BAlternative name(s): Protein XAP-5-like |
Gene namesi | Name:FAM50B Synonyms:X5L |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:18789, FAM50B |
MIMi | 614686, gene |
neXtProti | NX_Q9Y247 |
VEuPathDBi | HostDB:ENSG00000145945.5 |
Subcellular locationi
Nucleus
- nucleus Source: GO_Central
Pathology & Biotechi
Organism-specific databases
DisGeNETi | 26240 |
OpenTargetsi | ENSG00000145945 |
PharmGKBi | PA134912073 |
Miscellaneous databases
Pharosi | Q9Y247, Tdark |
Genetic variation databases
BioMutai | FAM50B |
DMDMi | 48474710 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Initiator methioninei | RemovedCombined sources | |||
ChainiPRO_0000068286 | 2 – 325 | Protein FAM50BAdd BLAST | 324 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 2 | N-acetylalanineCombined sources | 1 |
Keywords - PTMi
AcetylationProteomic databases
EPDi | Q9Y247 |
jPOSTi | Q9Y247 |
MassIVEi | Q9Y247 |
MaxQBi | Q9Y247 |
PaxDbi | Q9Y247 |
PeptideAtlasi | Q9Y247 |
PRIDEi | Q9Y247 |
ProteomicsDBi | 85644 |
PTM databases
iPTMneti | Q9Y247 |
PhosphoSitePlusi | Q9Y247 |
Expressioni
Tissue specificityi
Widely expressed. Mostly abundant in testis and adult and fetal brain.
Inductioni
Imprinted. Promoter methylation of the maternal allele may restrict expression to the paternal allele in placenta.1 Publication
Gene expression databases
Bgeei | ENSG00000145945, Expressed in prefrontal cortex and 218 other tissues |
ExpressionAtlasi | Q9Y247, baseline and differential |
Genevisiblei | Q9Y247, HS |
Organism-specific databases
HPAi | ENSG00000145945, Low tissue specificity |
Interactioni
Binary interactionsi
Hide detailsQ9Y247
Protein-protein interaction databases
BioGRIDi | 117631, 53 interactors |
IntActi | Q9Y247, 52 interactors |
MINTi | Q9Y247 |
STRINGi | 9606.ENSP00000369627 |
Miscellaneous databases
RNActi | Q9Y247, protein |
Family & Domainsi
Sequence similaritiesi
Belongs to the FAM50 family.Curated
Phylogenomic databases
eggNOGi | KOG2894, Eukaryota |
GeneTreei | ENSGT00390000004735 |
HOGENOMi | CLU_037985_1_1_1 |
InParanoidi | Q9Y247 |
OMAi | KVKREEM |
OrthoDBi | 1061864at2759 |
PhylomeDBi | Q9Y247 |
TreeFami | TF314738 |
Family and domain databases
InterProi | View protein in InterPro IPR007005, XAP5 |
PANTHERi | PTHR12722, PTHR12722, 1 hit |
Pfami | View protein in Pfam PF04921, XAP5, 1 hit |
i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
Q9Y247-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MAQYKGTMRE AGRAMHLLKK RERQREQMEV LKQRIAEETI LKSQVDKRFS
60 70 80 90 100
AHYDAVEAEL KSSTVGLVTL NDMKARQEAL VRERERQLAK RQHLEEQRLQ
110 120 130 140 150
QERQREQEQR RERKRKISCL SFALDDLDDQ ADAAEARRAG NLGKNPDVDT
160 170 180 190 200
SFLPDRDREE EENRLREELR QEWEAQREKV KDEEMEVTFS YWDGSGHRRT
210 220 230 240 250
VRVRKGNTVQ QFLKKALQGL RKDFLELRSA GVEQLMFIKE DLILPHYHTF
260 270 280 290 300
YDFIIARARG KSGPLFSFDV HDDVRLLSDA TMEKDESHAG KVVLRSWYEK
310 320
NKHIFPASRW EAYDPEKKWD KYTIR
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | Y18504 Genomic DNA Translation: CAB46273.1 Y18503 mRNA Translation: CAB46272.1 AL391422 Genomic DNA No translation available. CH471087 Genomic DNA Translation: EAW55142.1 BC001261 mRNA Translation: AAH01261.1 |
CCDSi | CCDS4487.1 |
RefSeqi | NP_036267.1, NM_012135.2 XP_016866218.1, XM_017010729.1 |
Genome annotation databases
Ensembli | ENST00000380274; ENSP00000369627; ENSG00000145945 ENST00000648326; ENSP00000496837; ENSG00000145945 |
GeneIDi | 26240 |
KEGGi | hsa:26240 |
UCSCi | uc003mvu.4, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | Y18504 Genomic DNA Translation: CAB46273.1 Y18503 mRNA Translation: CAB46272.1 AL391422 Genomic DNA No translation available. CH471087 Genomic DNA Translation: EAW55142.1 BC001261 mRNA Translation: AAH01261.1 |
CCDSi | CCDS4487.1 |
RefSeqi | NP_036267.1, NM_012135.2 XP_016866218.1, XM_017010729.1 |
3D structure databases
SMRi | Q9Y247 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 117631, 53 interactors |
IntActi | Q9Y247, 52 interactors |
MINTi | Q9Y247 |
STRINGi | 9606.ENSP00000369627 |
PTM databases
iPTMneti | Q9Y247 |
PhosphoSitePlusi | Q9Y247 |
Genetic variation databases
BioMutai | FAM50B |
DMDMi | 48474710 |
Proteomic databases
EPDi | Q9Y247 |
jPOSTi | Q9Y247 |
MassIVEi | Q9Y247 |
MaxQBi | Q9Y247 |
PaxDbi | Q9Y247 |
PeptideAtlasi | Q9Y247 |
PRIDEi | Q9Y247 |
ProteomicsDBi | 85644 |
Protocols and materials databases
Antibodypediai | 24439, 63 antibodies |
DNASUi | 26240 |
Genome annotation databases
Ensembli | ENST00000380274; ENSP00000369627; ENSG00000145945 ENST00000648326; ENSP00000496837; ENSG00000145945 |
GeneIDi | 26240 |
KEGGi | hsa:26240 |
UCSCi | uc003mvu.4, human |
Organism-specific databases
CTDi | 26240 |
DisGeNETi | 26240 |
GeneCardsi | FAM50B |
HGNCi | HGNC:18789, FAM50B |
HPAi | ENSG00000145945, Low tissue specificity |
MIMi | 614686, gene |
neXtProti | NX_Q9Y247 |
OpenTargetsi | ENSG00000145945 |
PharmGKBi | PA134912073 |
VEuPathDBi | HostDB:ENSG00000145945.5 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG2894, Eukaryota |
GeneTreei | ENSGT00390000004735 |
HOGENOMi | CLU_037985_1_1_1 |
InParanoidi | Q9Y247 |
OMAi | KVKREEM |
OrthoDBi | 1061864at2759 |
PhylomeDBi | Q9Y247 |
TreeFami | TF314738 |
Enzyme and pathway databases
PathwayCommonsi | Q9Y247 |
Miscellaneous databases
BioGRID-ORCSi | 26240, 5 hits in 868 CRISPR screens |
GenomeRNAii | 26240 |
Pharosi | Q9Y247, Tdark |
PROi | PR:Q9Y247 |
RNActi | Q9Y247, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000145945, Expressed in prefrontal cortex and 218 other tissues |
ExpressionAtlasi | Q9Y247, baseline and differential |
Genevisiblei | Q9Y247, HS |
Family and domain databases
InterProi | View protein in InterPro IPR007005, XAP5 |
PANTHERi | PTHR12722, PTHR12722, 1 hit |
Pfami | View protein in Pfam PF04921, XAP5, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | FA50B_HUMAN | |
Accessioni | Q9Y247Primary (citable) accession number: Q9Y247 Secondary accession number(s): Q5T2L6 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | October 10, 2003 |
Last sequence update: | November 1, 1999 | |
Last modified: | February 10, 2021 | |
This is version 130 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families - Human chromosome 6
Human chromosome 6: entries, gene names and cross-references to MIM