FAM50B

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Protein FAM50B Alternative name(s): Protein XAP-5-like
Gene namesⁱ	Name:FAM50B Synonyms:X5L
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 6

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000145945.5
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:18789 FAM50B
MIMⁱ	614686 gene
neXtProtⁱ	NX_Q9Y247

Subcellular locationⁱ

GO - Cellular component

Pathology & Biotechⁱ

Organism-specific databases

DisGeNET More...DisGeNETⁱ	26240
Open Targets More...OpenTargetsⁱ	ENSG00000145945
PharmGKBⁱ	PA134912073

Polymorphism and mutation databases

BioMutaⁱ	FAM50B
DMDMⁱ	48474710

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Initiator methionineⁱ		RemovedCombined sources
ChainⁱPRO_0000068286	2 – 325	Protein FAM50BAdd BLAST		324

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Modified residueⁱ	2	N-acetylalanineCombined sources		1

Keywords - PTMⁱ

Acetylation

Proteomic databases

EPDⁱ	Q9Y247
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	Q9Y247
PaxDbⁱ	Q9Y247
PeptideAtlas More...PeptideAtlasⁱ	Q9Y247
PRIDEⁱ	Q9Y247
ProteomicsDBⁱ	85644

PTM databases

iPTMnetⁱ	Q9Y247
PhosphoSitePlusⁱ	Q9Y247

Expressionⁱ

Tissue specificityⁱ

Widely expressed. Mostly abundant in testis and adult and fetal brain.

Inductionⁱ

Imprinted. Promoter methylation of the maternal allele may restrict expression to the paternal allele in placenta.1 Publication

Gene expression databases

Bgeeⁱ	ENSG00000145945 Expressed in 205 organ(s), highest expression level in nucleus accumbens
CleanExⁱ	HS_FAM50B
ExpressionAtlasⁱ	Q9Y247 baseline and differential
Genevisibleⁱ	Q9Y247 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA064111 HPA067817

HPAⁱ

HPA064111
HPA067817

Interactionⁱ

Binary interactionsⁱ

With	Entry	#Exp.	IntAct
ACTN2	P35609	3	EBI-742802,EBI-77797
CARD9	Q9H257	3	EBI-742802,EBI-751319
CCDC57	Q2TAC2	3	EBI-742802,EBI-2808286
GFAP	P14136	3	EBI-742802,EBI-744302
GOLGA2	Q08379	3	EBI-742802,EBI-618309
IKZF1	Q13422	4	EBI-742802,EBI-745305
LDOC1	O95751	4	EBI-742802,EBI-740738
TFIP11	Q9UBB9	3	EBI-742802,EBI-1105213
TRIM37	O94972	3	EBI-742802,EBI-741602

Protein-protein interaction databases

BioGridⁱ	117631, 16 interactors
IntActⁱ	Q9Y247, 49 interactors
Molecular INTeraction database More...MINTⁱ	Q9Y247
STRINGⁱ	9606.ENSP00000369625

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q9Y247
SMRⁱ	Q9Y247
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Sequence similaritiesⁱ

Belongs to the FAM50 family.Curated

Phylogenomic databases

eggNOGⁱ	KOG2894 Eukaryota ENOG410XNXM LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00390000004735
HOGENOMⁱ	HOG000283611
HOVERGENⁱ	HBG000678
InParanoidⁱ	Q9Y247
KEGG Orthology (KO) More...KOⁱ	K13119
OMAⁱ	YKGTMRE
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0KZY
PhylomeDBⁱ	Q9Y247
TreeFamⁱ	TF314738

Family and domain databases

InterProⁱ	View protein in InterPro IPR007005 XAP5
PANTHERⁱ	PTHR12722 PTHR12722, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF04921 XAP5, 1 hit

Sequenceⁱ

Sequence statusⁱ: Complete.

Sequence processingⁱ: The displayed sequence is further processed into a mature form.

Q9Y247-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MAQYKGTMRE AGRAMHLLKK RERQREQMEV LKQRIAEETI LKSQVDKRFS 
        60         70         80         90        100
AHYDAVEAEL KSSTVGLVTL NDMKARQEAL VRERERQLAK RQHLEEQRLQ 
       110        120        130        140        150
QERQREQEQR RERKRKISCL SFALDDLDDQ ADAAEARRAG NLGKNPDVDT 
       160        170        180        190        200
SFLPDRDREE EENRLREELR QEWEAQREKV KDEEMEVTFS YWDGSGHRRT 
       210        220        230        240        250
VRVRKGNTVQ QFLKKALQGL RKDFLELRSA GVEQLMFIKE DLILPHYHTF 
       260        270        280        290        300
YDFIIARARG KSGPLFSFDV HDDVRLLSDA TMEKDESHAG KVVLRSWYEK 
       310        320 
NKHIFPASRW EAYDPEKKWD KYTIR

Length:325

Mass (Da):38,709

Last modified:November 1, 1999 - v1

Checksum:ⁱ9F0653C3D7236997

GO

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	Y18504 Genomic DNA Translation: CAB46273.1 Y18503 mRNA Translation: CAB46272.1 AL391422 Genomic DNA No translation available. CH471087 Genomic DNA Translation: EAW55142.1 BC001261 mRNA Translation: AAH01261.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS4487.1
NCBI Reference Sequences More...RefSeqⁱ	NP_036267.1, NM_012135.2 XP_016866218.1, XM_017010729.1
UniGeneⁱ	Hs.140944 Hs.662301

Genome annotation databases

Ensemblⁱ	ENST00000380272; ENSP00000369625; ENSG00000145945 ENST00000380274; ENSP00000369627; ENSG00000145945
GeneIDⁱ	26240
KEGGⁱ	hsa:26240
UCSC genome browser More...UCSCⁱ	uc003mvu.4 human

Protein	Similar proteins		Species	Score	Length	Source
Q9Y247	Family with sequence similarity 50, member B, isoform CRA_a		HUMAN		325	UniRef100_Q9Y247

Protein	Similar proteins		Species	Score	Length	Source
Q9Y247	Protein FAM50B		MACFA		325	UniRef90_Q9Y247
Family with sequence similarity 50, member B, isoform CRA_a		HUMAN		325
Family with sequence similarity 50, member B		PANTR		342
Family with sequence similarity 50 member B		PONAB		341
Family with sequence similarity 50 member B		CALJA		328
+18

Protein	Similar proteins		Species	Score	Length	Source
Q9Y247	Protein FAM50B		MACFA		325	UniRef50_Q9Y247
Family with sequence similarity 50, member B, isoform CRA_a		HUMAN		325
Family with sequence similarity 50, member B		PANTR		342
Family with sequence similarity 50 member B		PONAB		341
Uncharacterized protein		AOTNA		328
+48

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	Y18504 Genomic DNA Translation: CAB46273.1 Y18503 mRNA Translation: CAB46272.1 AL391422 Genomic DNA No translation available. CH471087 Genomic DNA Translation: EAW55142.1 BC001261 mRNA Translation: AAH01261.1
CCDSⁱ	CCDS4487.1
RefSeqⁱ	NP_036267.1, NM_012135.2 XP_016866218.1, XM_017010729.1
UniGeneⁱ	Hs.140944 Hs.662301

3D structure databases

ProteinModelPortalⁱ	Q9Y247
SMRⁱ	Q9Y247
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	117631, 16 interactors
IntActⁱ	Q9Y247, 49 interactors
MINTⁱ	Q9Y247
STRINGⁱ	9606.ENSP00000369625

PTM databases

iPTMnetⁱ	Q9Y247
PhosphoSitePlusⁱ	Q9Y247

Polymorphism and mutation databases

BioMutaⁱ	FAM50B
DMDMⁱ	48474710

Proteomic databases

EPDⁱ	Q9Y247
MaxQBⁱ	Q9Y247
PaxDbⁱ	Q9Y247
PeptideAtlasⁱ	Q9Y247
PRIDEⁱ	Q9Y247
ProteomicsDBⁱ	85644

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	26240
Structural Biology Knowledgebase	Search...

Genome annotation databases

Ensemblⁱ	ENST00000380272; ENSP00000369625; ENSG00000145945 ENST00000380274; ENSP00000369627; ENSG00000145945
GeneIDⁱ	26240
KEGGⁱ	hsa:26240
UCSCⁱ	uc003mvu.4 human

Organism-specific databases

CTDⁱ	26240
DisGeNETⁱ	26240
EuPathDBⁱ	HostDB:ENSG00000145945.5
GeneCardsⁱ	FAM50B
HGNCⁱ	HGNC:18789 FAM50B
HPAⁱ	HPA064111 HPA067817
MIMⁱ	614686 gene
neXtProtⁱ	NX_Q9Y247
OpenTargetsⁱ	ENSG00000145945
PharmGKBⁱ	PA134912073
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG2894 Eukaryota ENOG410XNXM LUCA
GeneTreeⁱ	ENSGT00390000004735
HOGENOMⁱ	HOG000283611
HOVERGENⁱ	HBG000678
InParanoidⁱ	Q9Y247
KOⁱ	K13119
OMAⁱ	YKGTMRE
OrthoDBⁱ	EOG091G0KZY
PhylomeDBⁱ	Q9Y247
TreeFamⁱ	TF314738

Miscellaneous databases

GenomeRNAiⁱ	26240
Protein Ontology More...PROⁱ	PR:Q9Y247
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000145945 Expressed in 205 organ(s), highest expression level in nucleus accumbens
CleanExⁱ	HS_FAM50B
ExpressionAtlasⁱ	Q9Y247 baseline and differential
Genevisibleⁱ	Q9Y247 HS

Family and domain databases

InterProⁱ	View protein in InterPro IPR007005 XAP5
PANTHERⁱ	PTHR12722 PTHR12722, 1 hit
Pfamⁱ	View protein in Pfam PF04921 XAP5, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	FA50B_HUMAN
Accessionⁱ	Q9Y247Primary (citable) accession number: Q9Y247 Secondary accession number(s): Q5T2L6
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	October 10, 2003
	Last sequence update:	November 1, 1999
	Last modified:	September 12, 2018
	This is version 114 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

Human chromosome 6
Human chromosome 6: entries, gene names and cross-references to MIM
SIMILARITY comments
Index of protein domains and families
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - Q9Y247 (FA50B_HUMAN)

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Protein FAM50B

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<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted

Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

Family and domain databases

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

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Names & Taxonomyⁱ

Subcellular locationⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ