UniProtKB - Q9Y243 (AKT3_HUMAN)
RAC-gamma serine/threonine-protein kinase
AKT3
Functioni
Caution
Catalytic activityi
Activity regulationi
Kineticsi
- KM=87.9 µM for ATP (for purified and in vitro activated AKT3)1 Publication
- KM=12.4 µM for peptide substrate (for purified and in vitro activated AKT3)1 Publication
- KM=118.7 µM for ATP (for recombinant myristoylated AKT3 expressed and immunoprecipitated from Rat-1 cells)1 Publication
- KM=2.3 µM for peptide substrate (for recombinant myristoylated AKT3 expressed and immunoprecipitated from Rat-1 cells)1 Publication
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Binding sitei | 177 | ATPPROSITE-ProRule annotation | 1 | |
Active sitei | 271 | Proton acceptorPROSITE-ProRule annotation | 1 |
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Nucleotide bindingi | 154 – 162 | ATPPROSITE-ProRule annotation | 9 |
GO - Molecular functioni
- ATP binding Source: UniProtKB
- protein kinase activity Source: ProtInc
- protein serine/threonine kinase activity Source: UniProtKB
GO - Biological processi
- brain morphogenesis Source: Ensembl
- homeostasis of number of cells within a tissue Source: Ensembl
- intracellular signal transduction Source: GO_Central
- mitochondrial genome maintenance Source: UniProtKB
- negative regulation of cellular senescence Source: BHF-UCL
- peptidyl-serine phosphorylation Source: GO_Central
- positive regulation of artery morphogenesis Source: Ensembl
- positive regulation of blood vessel endothelial cell migration Source: BHF-UCL
- positive regulation of cell migration involved in sprouting angiogenesis Source: BHF-UCL
- positive regulation of cell size Source: Ensembl
- positive regulation of endothelial cell proliferation Source: BHF-UCL
- positive regulation of TOR signaling Source: Ensembl
- positive regulation of vascular endothelial cell proliferation Source: BHF-UCL
- protein phosphorylation Source: ProtInc
- signal transduction Source: UniProtKB
Keywordsi
Molecular function | Kinase, Serine/threonine-protein kinase, Transferase |
Ligand | ATP-binding, Nucleotide-binding |
Enzyme and pathway databases
BRENDAi | 2.7.11.1, 2681 |
PathwayCommonsi | Q9Y243 |
Reactomei | R-HSA-111447, Activation of BAD and translocation to mitochondria R-HSA-1257604, PIP3 activates AKT signaling R-HSA-1358803, Downregulation of ERBB2:ERBB3 signaling R-HSA-198323, AKT phosphorylates targets in the cytosol R-HSA-198693, AKT phosphorylates targets in the nucleus R-HSA-199418, Negative regulation of the PI3K/AKT network R-HSA-211163, AKT-mediated inactivation of FOXO1A R-HSA-389357, CD28 dependent PI3K/Akt signaling R-HSA-389513, CTLA4 inhibitory signaling R-HSA-392451, G beta:gamma signalling through PI3Kgamma R-HSA-5218920, VEGFR2 mediated vascular permeability R-HSA-5628897, TP53 Regulates Metabolic Genes R-HSA-5674400, Constitutive Signaling by AKT1 E17K in Cancer R-HSA-6804757, Regulation of TP53 Degradation R-HSA-6804758, Regulation of TP53 Activity through Acetylation R-HSA-6804759, Regulation of TP53 Activity through Association with Co-factors R-HSA-69202, Cyclin E associated events during G1/S transition R-HSA-69656, Cyclin A:Cdk2-associated events at S phase entry R-HSA-8876198, RAB GEFs exchange GTP for GDP on RABs R-HSA-8941332, RUNX2 regulates genes involved in cell migration R-HSA-8948751, Regulation of PTEN stability and activity R-HSA-9614399, Regulation of localization of FOXO transcription factors R-HSA-9634638, Estrogen-dependent nuclear events downstream of ESR-membrane signaling |
SABIO-RKi | Q9Y243 |
SignaLinki | Q9Y243 |
SIGNORi | Q9Y243 |
Names & Taxonomyi
Protein namesi | Recommended name: RAC-gamma serine/threonine-protein kinase (EC:2.7.11.1)Alternative name(s): Protein kinase Akt-3 Protein kinase B gamma Short name: PKB gamma RAC-PK-gamma STK-2 |
Gene namesi | Name:AKT3 Synonyms:PKBG |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
EuPathDBi | HostDB:ENSG00000117020.16 |
HGNCi | HGNC:393, AKT3 |
MIMi | 611223, gene |
neXtProti | NX_Q9Y243 |
Subcellular locationi
Nucleus
- Nucleus 1 Publication
Other locations
- Cytoplasm 1 Publication
- Membrane 1 Publication; Peripheral membrane protein 1 Publication
Note: Membrane-associated after cell stimulation leading to its translocation.
Keywords - Cellular componenti
Cytoplasm, Membrane, NucleusPathology & Biotechi
Involvement in diseasei
Megalencephaly-polymicrogyria-polydactyly-hydrocephalus syndrome 2 (MPPH2)4 Publications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_065830 | 17 | E → K in MPPH2 and melanoma; results in activation of AKT. 3 PublicationsCorresponds to variant dbSNP:rs397514606EnsemblClinVar. | 1 | |
Natural variantiVAR_069260 | 229 | N → S in MPPH2. 2 PublicationsCorresponds to variant dbSNP:rs397514605EnsemblClinVar. | 1 | |
Natural variantiVAR_069261 | 465 | R → W in MPPH2; disease phenotype overlaps with megalencephaly-capillary malformation syndrome. 1 PublicationCorresponds to variant dbSNP:rs587776935EnsemblClinVar. | 1 |
Mutagenesis
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Mutagenesisi | 305 | T → A: No activation after pervanadate treatment. 1 Publication | 1 | |
Mutagenesisi | 305 | T → D: 2-fold increase of phosphorylation steady state level, no activation after pervanadate treatment. 1 Publication | 1 | |
Mutagenesisi | 447 | T → A: No effect. 1 Publication | 1 | |
Mutagenesisi | 447 | T → D: No effect. 1 Publication | 1 | |
Mutagenesisi | 472 | S → A: 67% decrease of activity after pervanadate treatment. 1 Publication | 1 | |
Mutagenesisi | 472 | S → D: 1.4-fold increase of phosphorylation steady state level, 50% decrease of activity after pervanadate treatment. 1 Publication | 1 |
Keywords - Diseasei
Disease mutationOrganism-specific databases
DisGeNETi | 10000 |
GeneReviewsi | AKT3 |
MalaCardsi | AKT3 |
MIMi | 615937, phenotype |
OpenTargetsi | ENSG00000117020 |
Orphaneti | 99802, Hemimegalencephaly 83473, Megalencephaly-polymicrogyria-postaxial polydactyly-hydrocephalus syndrome |
PharmGKBi | PA24686 |
Miscellaneous databases
Pharosi | Q9Y243, Tchem |
Chemistry databases
ChEMBLi | CHEMBL4816 |
DrugCentrali | Q9Y243 |
GuidetoPHARMACOLOGYi | 2286 |
Polymorphism and mutation databases
BioMutai | AKT3 |
DMDMi | 12643943 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Initiator methioninei | RemovedCombined sources | |||
ChainiPRO_0000085611 | 2 – 479 | RAC-gamma serine/threonine-protein kinaseAdd BLAST | 478 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 2 | N-acetylserineCombined sources | 1 | |
Disulfide bondi | 59 ↔ 76 | By similarity | ||
Disulfide bondi | 293 ↔ 307 | By similarity | ||
Glycosylationi | 302 | O-linked (GlcNAc) threonineBy similarity | 1 | |
Modified residuei | 305 | Phosphothreonine; by PDPK11 Publication | 1 | |
Glycosylationi | 309 | O-linked (GlcNAc) threonineBy similarity | 1 | |
Modified residuei | 447 | PhosphothreonineCombined sources | 1 | |
Modified residuei | 472 | Phosphoserine; by PKC/PRKCZ1 Publication | 1 |
Post-translational modificationi
Keywords - PTMi
Acetylation, Disulfide bond, Glycoprotein, Phosphoprotein, Ubl conjugationProteomic databases
EPDi | Q9Y243 |
jPOSTi | Q9Y243 |
MassIVEi | Q9Y243 |
PaxDbi | Q9Y243 |
PeptideAtlasi | Q9Y243 |
PRIDEi | Q9Y243 |
ProteomicsDBi | 85641 [Q9Y243-1] 85642 [Q9Y243-2] |
PTM databases
GlyGeni | Q9Y243, 2 sites |
iPTMneti | Q9Y243 |
PhosphoSitePlusi | Q9Y243 |
Expressioni
Tissue specificityi
Gene expression databases
Bgeei | ENSG00000117020, Expressed in neocortex and 244 other tissues |
ExpressionAtlasi | Q9Y243, baseline and differential |
Genevisiblei | Q9Y243, HS |
Organism-specific databases
HPAi | ENSG00000117020, Low tissue specificity |
Interactioni
Subunit structurei
Interacts (via PH domain) with TCL1A; this enhances AKT3 phosphorylation and activation.
Interacts with TRAF6.
Interacts with KCTD20 (By similarity).
Interacts with BTBD10 (By similarity).
By similarity3 PublicationsBinary interactionsi
Hide detailsQ9Y243
With | #Exp. | IntAct |
---|---|---|
CASP3 [P42574] | 2 | EBI-296115,EBI-524064 |
CDC37 [Q16543] | 2 | EBI-296115,EBI-295634 |
TTC3 [P53804] | 2 | EBI-296115,EBI-2681313 |
Protein-protein interaction databases
BioGRIDi | 115318, 53 interactors |
DIPi | DIP-32584N |
IntActi | Q9Y243, 40 interactors |
MINTi | Q9Y243 |
STRINGi | 9606.ENSP00000263826 |
Chemistry databases
BindingDBi | Q9Y243 |
Miscellaneous databases
RNActi | Q9Y243, protein |
Structurei
Secondary structure
3D structure databases
SMRi | Q9Y243 |
ModBasei | Search... |
PDBe-KBi | Search... |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 5 – 107 | PHPROSITE-ProRule annotationAdd BLAST | 103 | |
Domaini | 148 – 405 | Protein kinasePROSITE-ProRule annotationAdd BLAST | 258 | |
Domaini | 406 – 479 | AGC-kinase C-terminalPROSITE-ProRule annotationAdd BLAST | 74 |
Domaini
Sequence similaritiesi
Phylogenomic databases
eggNOGi | KOG0690, Eukaryota |
GeneTreei | ENSGT00940000157060 |
HOGENOMi | CLU_000288_11_0_1 |
InParanoidi | Q9Y243 |
OMAi | CQIMSVD |
OrthoDBi | 787710at2759 |
PhylomeDBi | Q9Y243 |
TreeFami | TF102004 |
Family and domain databases
CDDi | cd01241, PH_PKB, 1 hit cd05593, STKc_PKB_gamma, 1 hit |
Gene3Di | 2.30.29.30, 1 hit |
InterProi | View protein in InterPro IPR000961, AGC-kinase_C IPR034675, Akt3 IPR011009, Kinase-like_dom_sf IPR011993, PH-like_dom_sf IPR001849, PH_domain IPR039026, PH_PKB IPR017892, Pkinase_C IPR000719, Prot_kinase_dom IPR017441, Protein_kinase_ATP_BS IPR039029, RAC_gamma-like IPR008271, Ser/Thr_kinase_AS |
PANTHERi | PTHR24351:SF199, PTHR24351:SF199, 1 hit |
Pfami | View protein in Pfam PF00169, PH, 1 hit PF00069, Pkinase, 1 hit PF00433, Pkinase_C, 1 hit |
SMARTi | View protein in SMART SM00233, PH, 1 hit SM00133, S_TK_X, 1 hit SM00220, S_TKc, 1 hit |
SUPFAMi | SSF56112, SSF56112, 1 hit |
PROSITEi | View protein in PROSITE PS51285, AGC_KINASE_CTER, 1 hit PS50003, PH_DOMAIN, 1 hit PS00107, PROTEIN_KINASE_ATP, 1 hit PS50011, PROTEIN_KINASE_DOM, 1 hit PS00108, PROTEIN_KINASE_ST, 1 hit |
s (2+)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 2 described isoforms and 6 potential isoforms that are computationally mapped.Show allAlign All
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MSDVTIVKEG WVQKRGEYIK NWRPRYFLLK TDGSFIGYKE KPQDVDLPYP
60 70 80 90 100
LNNFSVAKCQ LMKTERPKPN TFIIRCLQWT TVIERTFHVD TPEEREEWTE
110 120 130 140 150
AIQAVADRLQ RQEEERMNCS PTSQIDNIGE EEMDASTTHH KRKTMNDFDY
160 170 180 190 200
LKLLGKGTFG KVILVREKAS GKYYAMKILK KEVIIAKDEV AHTLTESRVL
210 220 230 240 250
KNTRHPFLTS LKYSFQTKDR LCFVMEYVNG GELFFHLSRE RVFSEDRTRF
260 270 280 290 300
YGAEIVSALD YLHSGKIVYR DLKLENLMLD KDGHIKITDF GLCKEGITDA
310 320 330 340 350
ATMKTFCGTP EYLAPEVLED NDYGRAVDWW GLGVVMYEMM CGRLPFYNQD
360 370 380 390 400
HEKLFELILM EDIKFPRTLS SDAKSLLSGL LIKDPNKRLG GGPDDAKEIM
410 420 430 440 450
RHSFFSGVNW QDVYDKKLVP PFKPQVTSET DTRYFDEEFT AQTITITPPE
460 470
KYDEDGMDCM DNERRPHFPQ FSYSASGRE
Computationally mapped potential isoform sequencesi
There are 6 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketA0A5F9ZHU3 | A0A5F9ZHU3_HUMAN | Non-specific serine/threonine prote... | AKT3 | 418 | Annotation score: | ||
A0A5K1VW74 | A0A5K1VW74_HUMAN | Non-specific serine/threonine prote... | AKT3 | 456 | Annotation score: | ||
A0A5F9ZGY0 | A0A5F9ZGY0_HUMAN | Non-specific serine/threonine prote... | AKT3 | 398 | Annotation score: | ||
F8VS91 | F8VS91_HUMAN | RAC-gamma serine/threonine-protein ... | AKT3 | 139 | Annotation score: | ||
A0A5F9ZGZ4 | A0A5F9ZGZ4_HUMAN | RAC-gamma serine/threonine-protein ... | AKT3 | 71 | Annotation score: | ||
A0A5F9ZHA9 | A0A5F9ZHA9_HUMAN | RAC-gamma serine/threonine-protein ... | AKT3 | 94 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 279 | L → R in AAI21155 (PubMed:15489334).Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_065830 | 17 | E → K in MPPH2 and melanoma; results in activation of AKT. 3 PublicationsCorresponds to variant dbSNP:rs397514606EnsemblClinVar. | 1 | |
Natural variantiVAR_040358 | 171 | G → R in a glioblastoma multiforme sample; somatic mutation. 1 PublicationCorresponds to variant dbSNP:rs1402272180Ensembl. | 1 | |
Natural variantiVAR_069260 | 229 | N → S in MPPH2. 2 PublicationsCorresponds to variant dbSNP:rs397514605EnsemblClinVar. | 1 | |
Natural variantiVAR_069261 | 465 | R → W in MPPH2; disease phenotype overlaps with megalencephaly-capillary malformation syndrome. 1 PublicationCorresponds to variant dbSNP:rs587776935EnsemblClinVar. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_004947 | 452 – 479 | YDEDG…ASGRE → CQQSDCGMLGNWKK in isoform 2. 3 PublicationsAdd BLAST | 28 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF124141 mRNA Translation: AAD29089.1 AF135794 mRNA Translation: AAD24196.1 AF085234 mRNA Translation: AAL40392.1 AJ245709 mRNA Translation: CAB53537.1 AL117525 mRNA Translation: CAB55977.1 Different termination. AY005799 mRNA Translation: AAF91073.1 AC096539 Genomic DNA No translation available. AL591721 Genomic DNA No translation available. AL592151 Genomic DNA No translation available. AL662889 Genomic DNA No translation available. CH471148 Genomic DNA Translation: EAW77093.1 CH471148 Genomic DNA Translation: EAW77094.1 BC121154 mRNA Translation: AAI21155.1 |
CCDSi | CCDS31076.1 [Q9Y243-2] CCDS31077.1 [Q9Y243-1] |
PIRi | A59380 T17287 |
RefSeqi | NP_001193658.1, NM_001206729.1 [Q9Y243-2] NP_005456.1, NM_005465.4 [Q9Y243-1] NP_859029.1, NM_181690.2 [Q9Y243-2] XP_005273051.1, XM_005272994.4 XP_005273052.1, XM_005272995.2 |
Genome annotation databases
Ensembli | ENST00000263826; ENSP00000263826; ENSG00000117020 [Q9Y243-1] ENST00000336199; ENSP00000336943; ENSG00000117020 [Q9Y243-2] ENST00000366540; ENSP00000355498; ENSG00000117020 [Q9Y243-2] ENST00000613395; ENSP00000479922; ENSG00000275199 [Q9Y243-2] ENST00000619536; ENSP00000483054; ENSG00000275199 [Q9Y243-2] ENST00000621586; ENSP00000479081; ENSG00000275199 [Q9Y243-1] ENST00000673466; ENSP00000500582; ENSG00000117020 [Q9Y243-1] |
GeneIDi | 10000 |
KEGGi | hsa:10000 |
UCSCi | uc001hzz.2, human [Q9Y243-1] |
Keywords - Coding sequence diversityi
Alternative splicing, PolymorphismSimilar proteinsi
Cross-referencesi
Web resourcesi
Atlas of Genetics and Cytogenetics in Oncology and Haematology |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF124141 mRNA Translation: AAD29089.1 AF135794 mRNA Translation: AAD24196.1 AF085234 mRNA Translation: AAL40392.1 AJ245709 mRNA Translation: CAB53537.1 AL117525 mRNA Translation: CAB55977.1 Different termination. AY005799 mRNA Translation: AAF91073.1 AC096539 Genomic DNA No translation available. AL591721 Genomic DNA No translation available. AL592151 Genomic DNA No translation available. AL662889 Genomic DNA No translation available. CH471148 Genomic DNA Translation: EAW77093.1 CH471148 Genomic DNA Translation: EAW77094.1 BC121154 mRNA Translation: AAI21155.1 |
CCDSi | CCDS31076.1 [Q9Y243-2] CCDS31077.1 [Q9Y243-1] |
PIRi | A59380 T17287 |
RefSeqi | NP_001193658.1, NM_001206729.1 [Q9Y243-2] NP_005456.1, NM_005465.4 [Q9Y243-1] NP_859029.1, NM_181690.2 [Q9Y243-2] XP_005273051.1, XM_005272994.4 XP_005273052.1, XM_005272995.2 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
2X18 | X-ray | 1.46 | A/B/C/D/E/F/G/H | 1-118 | [»] | |
SMRi | Q9Y243 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 115318, 53 interactors |
DIPi | DIP-32584N |
IntActi | Q9Y243, 40 interactors |
MINTi | Q9Y243 |
STRINGi | 9606.ENSP00000263826 |
Chemistry databases
BindingDBi | Q9Y243 |
ChEMBLi | CHEMBL4816 |
DrugCentrali | Q9Y243 |
GuidetoPHARMACOLOGYi | 2286 |
PTM databases
GlyGeni | Q9Y243, 2 sites |
iPTMneti | Q9Y243 |
PhosphoSitePlusi | Q9Y243 |
Polymorphism and mutation databases
BioMutai | AKT3 |
DMDMi | 12643943 |
Proteomic databases
EPDi | Q9Y243 |
jPOSTi | Q9Y243 |
MassIVEi | Q9Y243 |
PaxDbi | Q9Y243 |
PeptideAtlasi | Q9Y243 |
PRIDEi | Q9Y243 |
ProteomicsDBi | 85641 [Q9Y243-1] 85642 [Q9Y243-2] |
Protocols and materials databases
ABCDi | Q9Y243, 3 sequenced antibodies |
Antibodypediai | 3402, 1116 antibodies |
CPTCi | Q9Y243, 7 antibodies |
DNASUi | 10000 |
Genome annotation databases
Organism-specific databases
CTDi | 10000 |
DisGeNETi | 10000 |
EuPathDBi | HostDB:ENSG00000117020.16 |
GeneCardsi | AKT3 |
GeneReviewsi | AKT3 |
HGNCi | HGNC:393, AKT3 |
HPAi | ENSG00000117020, Low tissue specificity |
MalaCardsi | AKT3 |
MIMi | 611223, gene 615937, phenotype |
neXtProti | NX_Q9Y243 |
OpenTargetsi | ENSG00000117020 |
Orphaneti | 99802, Hemimegalencephaly 83473, Megalencephaly-polymicrogyria-postaxial polydactyly-hydrocephalus syndrome |
PharmGKBi | PA24686 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG0690, Eukaryota |
GeneTreei | ENSGT00940000157060 |
HOGENOMi | CLU_000288_11_0_1 |
InParanoidi | Q9Y243 |
OMAi | CQIMSVD |
OrthoDBi | 787710at2759 |
PhylomeDBi | Q9Y243 |
TreeFami | TF102004 |
Enzyme and pathway databases
BRENDAi | 2.7.11.1, 2681 |
PathwayCommonsi | Q9Y243 |
Reactomei | R-HSA-111447, Activation of BAD and translocation to mitochondria R-HSA-1257604, PIP3 activates AKT signaling R-HSA-1358803, Downregulation of ERBB2:ERBB3 signaling R-HSA-198323, AKT phosphorylates targets in the cytosol R-HSA-198693, AKT phosphorylates targets in the nucleus R-HSA-199418, Negative regulation of the PI3K/AKT network R-HSA-211163, AKT-mediated inactivation of FOXO1A R-HSA-389357, CD28 dependent PI3K/Akt signaling R-HSA-389513, CTLA4 inhibitory signaling R-HSA-392451, G beta:gamma signalling through PI3Kgamma R-HSA-5218920, VEGFR2 mediated vascular permeability R-HSA-5628897, TP53 Regulates Metabolic Genes R-HSA-5674400, Constitutive Signaling by AKT1 E17K in Cancer R-HSA-6804757, Regulation of TP53 Degradation R-HSA-6804758, Regulation of TP53 Activity through Acetylation R-HSA-6804759, Regulation of TP53 Activity through Association with Co-factors R-HSA-69202, Cyclin E associated events during G1/S transition R-HSA-69656, Cyclin A:Cdk2-associated events at S phase entry R-HSA-8876198, RAB GEFs exchange GTP for GDP on RABs R-HSA-8941332, RUNX2 regulates genes involved in cell migration R-HSA-8948751, Regulation of PTEN stability and activity R-HSA-9614399, Regulation of localization of FOXO transcription factors R-HSA-9634638, Estrogen-dependent nuclear events downstream of ESR-membrane signaling |
SABIO-RKi | Q9Y243 |
SignaLinki | Q9Y243 |
SIGNORi | Q9Y243 |
Miscellaneous databases
BioGRID-ORCSi | 10000, 4 hits in 875 CRISPR screens |
ChiTaRSi | AKT3, human |
GeneWikii | AKT3 |
GenomeRNAii | 10000 |
Pharosi | Q9Y243, Tchem |
PROi | PR:Q9Y243 |
RNActi | Q9Y243, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000117020, Expressed in neocortex and 244 other tissues |
ExpressionAtlasi | Q9Y243, baseline and differential |
Genevisiblei | Q9Y243, HS |
Family and domain databases
CDDi | cd01241, PH_PKB, 1 hit cd05593, STKc_PKB_gamma, 1 hit |
Gene3Di | 2.30.29.30, 1 hit |
InterProi | View protein in InterPro IPR000961, AGC-kinase_C IPR034675, Akt3 IPR011009, Kinase-like_dom_sf IPR011993, PH-like_dom_sf IPR001849, PH_domain IPR039026, PH_PKB IPR017892, Pkinase_C IPR000719, Prot_kinase_dom IPR017441, Protein_kinase_ATP_BS IPR039029, RAC_gamma-like IPR008271, Ser/Thr_kinase_AS |
PANTHERi | PTHR24351:SF199, PTHR24351:SF199, 1 hit |
Pfami | View protein in Pfam PF00169, PH, 1 hit PF00069, Pkinase, 1 hit PF00433, Pkinase_C, 1 hit |
SMARTi | View protein in SMART SM00233, PH, 1 hit SM00133, S_TK_X, 1 hit SM00220, S_TKc, 1 hit |
SUPFAMi | SSF56112, SSF56112, 1 hit |
PROSITEi | View protein in PROSITE PS51285, AGC_KINASE_CTER, 1 hit PS50003, PH_DOMAIN, 1 hit PS00107, PROTEIN_KINASE_ATP, 1 hit PS50011, PROTEIN_KINASE_DOM, 1 hit PS00108, PROTEIN_KINASE_ST, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | AKT3_HUMAN | |
Accessioni | Q9Y243Primary (citable) accession number: Q9Y243 Secondary accession number(s): Q0VAA6 Q9UFP5 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | December 1, 2000 |
Last sequence update: | November 1, 1999 | |
Last modified: | December 2, 2020 | |
This is version 213 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families - Human chromosome 1
Human chromosome 1: entries, gene names and cross-references to MIM - Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations - Human and mouse protein kinases
Human and mouse protein kinases: classification and index