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Entry version 219 (25 May 2022)
Sequence version 1 (01 Nov 1999)
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Protein

RAC-gamma serine/threonine-protein kinase

Gene

AKT3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

AKT3 is one of 3 closely related serine/threonine-protein kinases (AKT1, AKT2 and AKT3) called the AKT kinase, and which regulate many processes including metabolism, proliferation, cell survival, growth and angiogenesis. This is mediated through serine and/or threonine phosphorylation of a range of downstream substrates. Over 100 substrate candidates have been reported so far, but for most of them, no isoform specificity has been reported. AKT3 is the least studied AKT isoform. It plays an important role in brain development and is crucial for the viability of malignant glioma cells. AKT3 isoform may also be the key molecule in up-regulation and down-regulation of MMP13 via IL13. Required for the coordination of mitochondrial biogenesis with growth factor-induced increases in cellular energy demands. Down-regulation by RNA interference reduces the expression of the phosphorylated form of BAD, resulting in the induction of caspase-dependent apoptosis.

2 Publications

Caution

In light of strong homologies in the primary amino acid sequence, the 3 AKT kinases were long surmised to play redundant and overlapping roles. More recent studies has brought into question the redundancy within AKT kinase isoforms and instead pointed to isoform specific functions in different cellular events and diseases. AKT1 is more specifically involved in cellular survival pathways, by inhibiting apoptotic processes; whereas AKT2 is more specific for the insulin receptor signaling pathway. Moreover, while AKT1 and AKT2 are often implicated in many aspects of cellular transformation, the 2 isoforms act in a complementary opposing manner. The role of AKT3 is less clear, though it appears to be predominantly expressed in brain.Curated

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes regulatory mechanisms for enzymes, transporters or microbial transcription factors, and reports the components which regulate (by activation or inhibition) the reaction.<p><a href='/help/activity_regulation' target='_top'>More...</a></p>Activity regulationi

Two specific sites, one in the kinase domain (Thr-305) and the other in the C-terminal regulatory region (Ser-472), need to be phosphorylated for its full activation (By similarity). IGF-1 leads to the activation of AKT3, which may play a role in regulating cell survival.By similarity

<p>This subsection of the 'Function' section describes biophysical and chemical properties, such as maximal absorption, kinetic parameters, pH dependence, redox potentials and temperature dependence.<p><a href='/help/biophysicochemical_properties' target='_top'>More...</a></p>Kineticsi

  1. KM=87.9 µM for ATP (for purified and in vitro activated AKT3)1 Publication
  2. KM=12.4 µM for peptide substrate (for purified and in vitro activated AKT3)1 Publication
  3. KM=118.7 µM for ATP (for recombinant myristoylated AKT3 expressed and immunoprecipitated from Rat-1 cells)1 Publication
  4. KM=2.3 µM for peptide substrate (for recombinant myristoylated AKT3 expressed and immunoprecipitated from Rat-1 cells)1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei177ATPPROSITE-ProRule annotation1
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei271Proton acceptorPROSITE-ProRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi154 – 162ATPPROSITE-ProRule annotation9

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionKinase, Serine/threonine-protein kinase, Transferase
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

BRENDA Comprehensive Enzyme Information System

More...
BRENDAi
2.7.11.1, 2681

Pathway Commons web resource for biological pathway data

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PathwayCommonsi
Q9Y243

Reactome - a knowledgebase of biological pathways and processes

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Reactomei
R-HSA-111447, Activation of BAD and translocation to mitochondria
R-HSA-1257604, PIP3 activates AKT signaling
R-HSA-1358803, Downregulation of ERBB2:ERBB3 signaling
R-HSA-198323, AKT phosphorylates targets in the cytosol
R-HSA-198693, AKT phosphorylates targets in the nucleus
R-HSA-199418, Negative regulation of the PI3K/AKT network
R-HSA-211163, AKT-mediated inactivation of FOXO1A
R-HSA-389357, CD28 dependent PI3K/Akt signaling
R-HSA-389513, CTLA4 inhibitory signaling
R-HSA-392451, G beta:gamma signalling through PI3Kgamma
R-HSA-5218920, VEGFR2 mediated vascular permeability
R-HSA-5628897, TP53 Regulates Metabolic Genes
R-HSA-5674400, Constitutive Signaling by AKT1 E17K in Cancer
R-HSA-6804757, Regulation of TP53 Degradation
R-HSA-6804758, Regulation of TP53 Activity through Acetylation
R-HSA-6804759, Regulation of TP53 Activity through Association with Co-factors
R-HSA-69202, Cyclin E associated events during G1/S transition
R-HSA-69656, Cyclin A:Cdk2-associated events at S phase entry
R-HSA-8876198, RAB GEFs exchange GTP for GDP on RABs
R-HSA-8941332, RUNX2 regulates genes involved in cell migration
R-HSA-8948751, Regulation of PTEN stability and activity
R-HSA-9607240, FLT3 Signaling
R-HSA-9614399, Regulation of localization of FOXO transcription factors
R-HSA-9634638, Estrogen-dependent nuclear events downstream of ESR-membrane signaling

SABIO-RK: Biochemical Reaction Kinetics Database

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SABIO-RKi
Q9Y243

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...
SignaLinki
Q9Y243

SIGNOR Signaling Network Open Resource

More...
SIGNORi
Q9Y243

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
RAC-gamma serine/threonine-protein kinase (EC:2.7.11.1)
Alternative name(s):
Protein kinase Akt-3
Protein kinase B gamma
Short name:
PKB gamma
RAC-PK-gamma
STK-2
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:AKT3
Synonyms:PKBG
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 1

Organism-specific databases

Human Gene Nomenclature Database

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HGNCi
HGNC:393, AKT3

Online Mendelian Inheritance in Man (OMIM)

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MIMi
611223, gene

neXtProt; the human protein knowledge platform

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neXtProti
NX_Q9Y243

Eukaryotic Pathogen, Vector and Host Database Resources

More...
VEuPathDBi
HostDB:ENSG00000117020

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Cytoplasm, Membrane, Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the 'Pathology and Biotech' section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

AKT3 is a key modulator of several tumors like melanoma, glioma and ovarian cancer. Active AKT3 increases progressively during melanoma tumor progression with highest levels present in advanced-stage metastatic melanomas. Promotes melanoma tumorigenesis by decreasing apoptosis. Plays a key role in the genesis of ovarian cancers through modulation of G2/M phase transition. With AKT2, plays a pivotal role in the biology of glioblastoma.
Megalencephaly-polymicrogyria-polydactyly-hydrocephalus syndrome 2 (MPPH2)4 Publications
The disease is caused by variants affecting the gene represented in this entry.
Disease descriptionA syndrome characterized by megalencephaly, hydrocephalus, and polymicrogyria; polydactyly may also be seen. There is considerable phenotypic similarity between this disorder and the megalencephaly-capillary malformation syndrome.
Related information in OMIM
Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_06583017E → K in MPPH2 and melanoma; results in activation of AKT. 3 PublicationsCorresponds to variant dbSNP:rs397514606EnsemblClinVar.1
Natural variantiVAR_069260229N → S in MPPH2. 2 PublicationsCorresponds to variant dbSNP:rs397514605EnsemblClinVar.1
Natural variantiVAR_069261465R → W in MPPH2; disease phenotype overlaps with megalencephaly-capillary malformation syndrome. 1 PublicationCorresponds to variant dbSNP:rs587776935EnsemblClinVar.1

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology%5Fand%5Fbiotech%5Fsection">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi305T → A: No activation after pervanadate treatment. 1 Publication1
Mutagenesisi305T → D: 2-fold increase of phosphorylation steady state level, no activation after pervanadate treatment. 1 Publication1
Mutagenesisi447T → A: No effect. 1 Publication1
Mutagenesisi447T → D: No effect. 1 Publication1
Mutagenesisi472S → A: 67% decrease of activity after pervanadate treatment. 1 Publication1
Mutagenesisi472S → D: 1.4-fold increase of phosphorylation steady state level, 50% decrease of activity after pervanadate treatment. 1 Publication1

Keywords - Diseasei

Disease variant

Organism-specific databases

DisGeNET

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DisGeNETi
10000

GeneReviews a resource of expert-authored, peer-reviewed disease descriptions.

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GeneReviewsi
AKT3

MalaCards human disease database

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MalaCardsi
AKT3
MIMi615937, phenotype

Open Targets

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OpenTargetsi
ENSG00000117020

Orphanet; a database dedicated to information on rare diseases and orphan drugs

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Orphaneti
99802, Hemimegalencephaly
83473, Megalencephaly-polymicrogyria-postaxial polydactyly-hydrocephalus syndrome

The Pharmacogenetics and Pharmacogenomics Knowledge Base

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PharmGKBi
PA24686

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

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Pharosi
Q9Y243, Tchem

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

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ChEMBLi
CHEMBL4816

DrugCentral

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DrugCentrali
Q9Y243

IUPHAR/BPS Guide to PHARMACOLOGY

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GuidetoPHARMACOLOGYi
2286

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

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BioMutai
AKT3

Domain mapping of disease mutations (DMDM)

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DMDMi
12643943

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section indicates that the initiator methionine is cleaved from the mature protein.<p><a href='/help/init_met' target='_top'>More...</a></p>Initiator methionineiRemovedCombined sources
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000856112 – 479RAC-gamma serine/threonine-protein kinaseAdd BLAST478

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei2N-acetylserineCombined sources1
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi59 ↔ 76By similarity
Disulfide bondi293 ↔ 307By similarity
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi302O-linked (GlcNAc) threonineBy similarity1
Modified residuei305Phosphothreonine; by PDPK11 Publication1
Glycosylationi309O-linked (GlcNAc) threonineBy similarity1
Modified residuei447PhosphothreonineCombined sources1
Modified residuei472Phosphoserine; by PKC/PRKCZ1 Publication1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Phosphorylation on Thr-305 and Ser-472 is required for full activity.By similarity
Ubiquitinated. When fully phosphorylated and translocated into the nucleus, undergoes 'Lys-48'-polyubiquitination catalyzed by TTC3, leading to its degradation by the proteasome.3 Publications
O-GlcNAcylation at Thr-302 and Thr-309 inhibits activating phosphorylation at Thr-305 via disrupting the interaction between AKT and PDK1.By similarity

Keywords - PTMi

Acetylation, Disulfide bond, Glycoprotein, Phosphoprotein, Ubl conjugation

Proteomic databases

Encyclopedia of Proteome Dynamics

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EPDi
Q9Y243

jPOST - Japan Proteome Standard Repository/Database

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jPOSTi
Q9Y243

MassIVE - Mass Spectrometry Interactive Virtual Environment

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MassIVEi
Q9Y243

MaxQB - The MaxQuant DataBase

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MaxQBi
Q9Y243

PaxDb, a database of protein abundance averages across all three domains of life

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PaxDbi
Q9Y243

PeptideAtlas

More...
PeptideAtlasi
Q9Y243

PRoteomics IDEntifications database

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PRIDEi
Q9Y243

ProteomicsDB: a multi-organism proteome resource

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ProteomicsDBi
85641 [Q9Y243-1]
85642 [Q9Y243-2]

PTM databases

GlyGen: Computational and Informatics Resources for Glycoscience

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GlyGeni
Q9Y243, 3 sites, 1 O-linked glycan (1 site)

iPTMnet integrated resource for PTMs in systems biology context

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iPTMneti
Q9Y243

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q9Y243

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

In adult tissues, it is highly expressed in brain, lung and kidney, but weakly in heart, testis and liver. In fetal tissues, it is highly expressed in heart, liver and brain and not at all in kidney.

Gene expression databases

Bgee dataBase for Gene Expression Evolution

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Bgeei
ENSG00000117020, Expressed in neocortex and 245 other tissues

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
Q9Y243, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
Q9Y243, HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
ENSG00000117020, Tissue enhanced (brain)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts (via PH domain) with TCL1A; this enhances AKT3 phosphorylation and activation.

Interacts with TRAF6.

Interacts with KCTD20 (By similarity).

Interacts with BTBD10 (By similarity).

By similarity3 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

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Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

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BioGRIDi
115318, 59 interactors

Database of interacting proteins

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DIPi
DIP-32584N

Protein interaction database and analysis system

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IntActi
Q9Y243, 47 interactors

Molecular INTeraction database

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MINTi
Q9Y243

STRING: functional protein association networks

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STRINGi
9606.ENSP00000263826

Chemistry databases

BindingDB database of measured binding affinities

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BindingDBi
Q9Y243

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q9Y243, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1479
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

AlphaFold Protein Structure Database

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AlphaFoldDBi
Q9Y243

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
Q9Y243

Database of comparative protein structure models

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ModBasei
Search...

Protein Data Bank in Europe - Knowledge Base

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PDBe-KBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini5 – 107PHPROSITE-ProRule annotationAdd BLAST103
Domaini148 – 405Protein kinasePROSITE-ProRule annotationAdd BLAST258
Domaini406 – 479AGC-kinase C-terminalPROSITE-ProRule annotationAdd BLAST74

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni458 – 479DisorderedSequence analysisAdd BLAST22

<p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

Binding of the PH domain to the phosphatidylinositol 3-kinase alpha (PI3K) results in its targeting to the plasma membrane.

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
KOG0690, Eukaryota

Ensembl GeneTree

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GeneTreei
ENSGT00940000157060

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

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HOGENOMi
CLU_000288_11_0_1

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
Q9Y243

Identification of Orthologs from Complete Genome Data

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OMAi
XLGGGPD

Database of Orthologous Groups

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OrthoDBi
787710at2759

Database for complete collections of gene phylogenies

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PhylomeDBi
Q9Y243

TreeFam database of animal gene trees

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TreeFami
TF102004

Family and domain databases

Conserved Domains Database

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CDDi
cd01241, PH_PKB, 1 hit
cd05593, STKc_PKB_gamma, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

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Gene3Di
2.30.29.30, 1 hit

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR000961, AGC-kinase_C
IPR034675, Akt3
IPR011009, Kinase-like_dom_sf
IPR011993, PH-like_dom_sf
IPR001849, PH_domain
IPR039026, PH_PKB
IPR017892, Pkinase_C
IPR000719, Prot_kinase_dom
IPR017441, Protein_kinase_ATP_BS
IPR039029, RAC_gamma-like
IPR008271, Ser/Thr_kinase_AS

The PANTHER Classification System

More...
PANTHERi
PTHR24351:SF199, PTHR24351:SF199, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00169, PH, 1 hit
PF00069, Pkinase, 1 hit
PF00433, Pkinase_C, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00233, PH, 1 hit
SM00133, S_TK_X, 1 hit
SM00220, S_TKc, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF56112, SSF56112, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51285, AGC_KINASE_CTER, 1 hit
PS50003, PH_DOMAIN, 1 hit
PS00107, PROTEIN_KINASE_ATP, 1 hit
PS50011, PROTEIN_KINASE_DOM, 1 hit
PS00108, PROTEIN_KINASE_ST, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 11 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q9Y243-1) [UniParc]FASTAAdd to basket
Also known as: PKB gamma

This isoform has been chosen as the <p><strong>What is the canonical sequence?</strong><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MSDVTIVKEG WVQKRGEYIK NWRPRYFLLK TDGSFIGYKE KPQDVDLPYP
60 70 80 90 100
LNNFSVAKCQ LMKTERPKPN TFIIRCLQWT TVIERTFHVD TPEEREEWTE
110 120 130 140 150
AIQAVADRLQ RQEEERMNCS PTSQIDNIGE EEMDASTTHH KRKTMNDFDY
160 170 180 190 200
LKLLGKGTFG KVILVREKAS GKYYAMKILK KEVIIAKDEV AHTLTESRVL
210 220 230 240 250
KNTRHPFLTS LKYSFQTKDR LCFVMEYVNG GELFFHLSRE RVFSEDRTRF
260 270 280 290 300
YGAEIVSALD YLHSGKIVYR DLKLENLMLD KDGHIKITDF GLCKEGITDA
310 320 330 340 350
ATMKTFCGTP EYLAPEVLED NDYGRAVDWW GLGVVMYEMM CGRLPFYNQD
360 370 380 390 400
HEKLFELILM EDIKFPRTLS SDAKSLLSGL LIKDPNKRLG GGPDDAKEIM
410 420 430 440 450
RHSFFSGVNW QDVYDKKLVP PFKPQVTSET DTRYFDEEFT AQTITITPPE
460 470
KYDEDGMDCM DNERRPHFPQ FSYSASGRE
Length:479
Mass (Da):55,775
Last modified:November 1, 1999 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iF08BDDE6502E78FB
GO
Isoform 2 (identifier: Q9Y243-2) [UniParc]FASTAAdd to basket
Also known as: PKB gamma 1

The sequence of this isoform differs from the canonical sequence as follows:
     452-479: YDEDGMDCMDNERRPHFPQFSYSASGRE → CQQSDCGMLGNWKK

Show »
Length:465
Mass (Da):54,032
Checksum:i592EF88B6937D1E0
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 11 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A5F9ZHU3A0A5F9ZHU3_HUMAN
Non-specific serine/threonine prote...
AKT3
418Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A5F9ZGY0A0A5F9ZGY0_HUMAN
Non-specific serine/threonine prote...
AKT3
398Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A5K1VW74A0A5K1VW74_HUMAN
Non-specific serine/threonine prote...
AKT3
456Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A7P0T8T9A0A7P0T8T9_HUMAN
Non-specific serine/threonine prote...
AKT3
437Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A7P0TB32A0A7P0TB32_HUMAN
RAC-gamma serine/threonine-protein ...
AKT3
295Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A7P0TBJ6A0A7P0TBJ6_HUMAN
RAC-gamma serine/threonine-protein ...
AKT3
247Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F8VS91F8VS91_HUMAN
RAC-gamma serine/threonine-protein ...
AKT3
139Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A5F9ZGZ4A0A5F9ZGZ4_HUMAN
RAC-gamma serine/threonine-protein ...
AKT3
71Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A5F9ZHA9A0A5F9ZHA9_HUMAN
RAC-gamma serine/threonine-protein ...
AKT3
94Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A7P0TB29A0A7P0TB29_HUMAN
RAC-gamma serine/threonine-protein ...
AKT3
100Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
There is more potential isoformShow all

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti279L → R in AAI21155 (PubMed:15489334).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_06583017E → K in MPPH2 and melanoma; results in activation of AKT. 3 PublicationsCorresponds to variant dbSNP:rs397514606EnsemblClinVar.1
Natural variantiVAR_040358171G → R in a glioblastoma multiforme sample; somatic mutation. 1 PublicationCorresponds to variant dbSNP:rs1402272180Ensembl.1
Natural variantiVAR_069260229N → S in MPPH2. 2 PublicationsCorresponds to variant dbSNP:rs397514605EnsemblClinVar.1
Natural variantiVAR_069261465R → W in MPPH2; disease phenotype overlaps with megalencephaly-capillary malformation syndrome. 1 PublicationCorresponds to variant dbSNP:rs587776935EnsemblClinVar.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_004947452 – 479YDEDG…ASGRE → CQQSDCGMLGNWKK in isoform 2. 3 PublicationsAdd BLAST28

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF124141 mRNA Translation: AAD29089.1
AF135794 mRNA Translation: AAD24196.1
AF085234 mRNA Translation: AAL40392.1
AJ245709 mRNA Translation: CAB53537.1
AL117525 mRNA Translation: CAB55977.1 Different termination.
AY005799 mRNA Translation: AAF91073.1
AC096539 Genomic DNA No translation available.
AL591721 Genomic DNA No translation available.
AL592151 Genomic DNA No translation available.
AL662889 Genomic DNA No translation available.
CH471148 Genomic DNA Translation: EAW77093.1
CH471148 Genomic DNA Translation: EAW77094.1
BC121154 mRNA Translation: AAI21155.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS31076.1 [Q9Y243-2]
CCDS31077.1 [Q9Y243-1]

Protein sequence database of the Protein Information Resource

More...
PIRi
A59380
T17287

NCBI Reference Sequences

More...
RefSeqi
NP_001193658.1, NM_001206729.1 [Q9Y243-2]
NP_005456.1, NM_005465.4 [Q9Y243-1]
NP_859029.1, NM_181690.2 [Q9Y243-2]
XP_005273051.1, XM_005272994.4
XP_005273052.1, XM_005272995.2

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000263826.12; ENSP00000263826.5; ENSG00000117020.19
ENST00000336199.9; ENSP00000336943.5; ENSG00000117020.19 [Q9Y243-2]
ENST00000366540.5; ENSP00000355498.1; ENSG00000117020.19 [Q9Y243-2]
ENST00000613395.4; ENSP00000479922.1; ENSG00000275199.4 [Q9Y243-2]
ENST00000619536.4; ENSP00000483054.1; ENSG00000275199.4 [Q9Y243-2]
ENST00000621586.3; ENSP00000479081.1; ENSG00000275199.4
ENST00000673466.1; ENSP00000500582.1; ENSG00000117020.19
ENST00000680118.1; ENSP00000505276.1; ENSG00000117020.19

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
10000

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:10000

Matched Annotation from NCBI and EMBL-EBI (MANE) - Phase one

More...
MANE-Selecti
ENST00000673466.1; ENSP00000500582.1; NM_005465.7; NP_005456.1

UCSC genome browser

More...
UCSCi
uc001hzz.2, human [Q9Y243-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross%5Freferences%5Fsection">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF124141 mRNA Translation: AAD29089.1
AF135794 mRNA Translation: AAD24196.1
AF085234 mRNA Translation: AAL40392.1
AJ245709 mRNA Translation: CAB53537.1
AL117525 mRNA Translation: CAB55977.1 Different termination.
AY005799 mRNA Translation: AAF91073.1
AC096539 Genomic DNA No translation available.
AL591721 Genomic DNA No translation available.
AL592151 Genomic DNA No translation available.
AL662889 Genomic DNA No translation available.
CH471148 Genomic DNA Translation: EAW77093.1
CH471148 Genomic DNA Translation: EAW77094.1
BC121154 mRNA Translation: AAI21155.1
CCDSiCCDS31076.1 [Q9Y243-2]
CCDS31077.1 [Q9Y243-1]
PIRiA59380
T17287
RefSeqiNP_001193658.1, NM_001206729.1 [Q9Y243-2]
NP_005456.1, NM_005465.4 [Q9Y243-1]
NP_859029.1, NM_181690.2 [Q9Y243-2]
XP_005273051.1, XM_005272994.4
XP_005273052.1, XM_005272995.2

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...
PDBei

Protein Data Bank RCSB

More...
RCSB PDBi

Protein Data Bank Japan

More...
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2X18X-ray1.46A/B/C/D/E/F/G/H1-118[»]
AlphaFoldDBiQ9Y243
SMRiQ9Y243
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi115318, 59 interactors
DIPiDIP-32584N
IntActiQ9Y243, 47 interactors
MINTiQ9Y243
STRINGi9606.ENSP00000263826

Chemistry databases

BindingDBiQ9Y243
ChEMBLiCHEMBL4816
DrugCentraliQ9Y243
GuidetoPHARMACOLOGYi2286

PTM databases

GlyGeniQ9Y243, 3 sites, 1 O-linked glycan (1 site)
iPTMnetiQ9Y243
PhosphoSitePlusiQ9Y243

Genetic variation databases

BioMutaiAKT3
DMDMi12643943

Proteomic databases

EPDiQ9Y243
jPOSTiQ9Y243
MassIVEiQ9Y243
MaxQBiQ9Y243
PaxDbiQ9Y243
PeptideAtlasiQ9Y243
PRIDEiQ9Y243
ProteomicsDBi85641 [Q9Y243-1]
85642 [Q9Y243-2]

Protocols and materials databases

ABCD curated depository of sequenced antibodies

More...
ABCDi
Q9Y243, 3 sequenced antibodies

Antibodypedia a portal for validated antibodies

More...
Antibodypediai
3402, 1156 antibodies from 46 providers

The CPTC Antibody Portal

More...
CPTCi
Q9Y243, 7 antibodies

The DNASU plasmid repository

More...
DNASUi
10000

Genome annotation databases

EnsembliENST00000263826.12; ENSP00000263826.5; ENSG00000117020.19
ENST00000336199.9; ENSP00000336943.5; ENSG00000117020.19 [Q9Y243-2]
ENST00000366540.5; ENSP00000355498.1; ENSG00000117020.19 [Q9Y243-2]
ENST00000613395.4; ENSP00000479922.1; ENSG00000275199.4 [Q9Y243-2]
ENST00000619536.4; ENSP00000483054.1; ENSG00000275199.4 [Q9Y243-2]
ENST00000621586.3; ENSP00000479081.1; ENSG00000275199.4
ENST00000673466.1; ENSP00000500582.1; ENSG00000117020.19
ENST00000680118.1; ENSP00000505276.1; ENSG00000117020.19
GeneIDi10000
KEGGihsa:10000
MANE-SelectiENST00000673466.1; ENSP00000500582.1; NM_005465.7; NP_005456.1
UCSCiuc001hzz.2, human [Q9Y243-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
10000
DisGeNETi10000

GeneCards: human genes, protein and diseases

More...
GeneCardsi
AKT3
GeneReviewsiAKT3
HGNCiHGNC:393, AKT3
HPAiENSG00000117020, Tissue enhanced (brain)
MalaCardsiAKT3
MIMi611223, gene
615937, phenotype
neXtProtiNX_Q9Y243
OpenTargetsiENSG00000117020
Orphaneti99802, Hemimegalencephaly
83473, Megalencephaly-polymicrogyria-postaxial polydactyly-hydrocephalus syndrome
PharmGKBiPA24686
VEuPathDBiHostDB:ENSG00000117020

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG0690, Eukaryota
GeneTreeiENSGT00940000157060
HOGENOMiCLU_000288_11_0_1
InParanoidiQ9Y243
OMAiXLGGGPD
OrthoDBi787710at2759
PhylomeDBiQ9Y243
TreeFamiTF102004

Enzyme and pathway databases

BRENDAi2.7.11.1, 2681
PathwayCommonsiQ9Y243
ReactomeiR-HSA-111447, Activation of BAD and translocation to mitochondria
R-HSA-1257604, PIP3 activates AKT signaling
R-HSA-1358803, Downregulation of ERBB2:ERBB3 signaling
R-HSA-198323, AKT phosphorylates targets in the cytosol
R-HSA-198693, AKT phosphorylates targets in the nucleus
R-HSA-199418, Negative regulation of the PI3K/AKT network
R-HSA-211163, AKT-mediated inactivation of FOXO1A
R-HSA-389357, CD28 dependent PI3K/Akt signaling
R-HSA-389513, CTLA4 inhibitory signaling
R-HSA-392451, G beta:gamma signalling through PI3Kgamma
R-HSA-5218920, VEGFR2 mediated vascular permeability
R-HSA-5628897, TP53 Regulates Metabolic Genes
R-HSA-5674400, Constitutive Signaling by AKT1 E17K in Cancer
R-HSA-6804757, Regulation of TP53 Degradation
R-HSA-6804758, Regulation of TP53 Activity through Acetylation
R-HSA-6804759, Regulation of TP53 Activity through Association with Co-factors
R-HSA-69202, Cyclin E associated events during G1/S transition
R-HSA-69656, Cyclin A:Cdk2-associated events at S phase entry
R-HSA-8876198, RAB GEFs exchange GTP for GDP on RABs
R-HSA-8941332, RUNX2 regulates genes involved in cell migration
R-HSA-8948751, Regulation of PTEN stability and activity
R-HSA-9607240, FLT3 Signaling
R-HSA-9614399, Regulation of localization of FOXO transcription factors
R-HSA-9634638, Estrogen-dependent nuclear events downstream of ESR-membrane signaling
SABIO-RKiQ9Y243
SignaLinkiQ9Y243
SIGNORiQ9Y243

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...
BioGRID-ORCSi
10000, 12 hits in 1117 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
AKT3, human

The Gene Wiki collection of pages on human genes and proteins

More...
GeneWikii
AKT3

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
10000
PharosiQ9Y243, Tchem

Protein Ontology

More...
PROi
PR:Q9Y243
RNActiQ9Y243, protein

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000117020, Expressed in neocortex and 245 other tissues
ExpressionAtlasiQ9Y243, baseline and differential
GenevisibleiQ9Y243, HS

Family and domain databases

CDDicd01241, PH_PKB, 1 hit
cd05593, STKc_PKB_gamma, 1 hit
Gene3Di2.30.29.30, 1 hit
InterProiView protein in InterPro
IPR000961, AGC-kinase_C
IPR034675, Akt3
IPR011009, Kinase-like_dom_sf
IPR011993, PH-like_dom_sf
IPR001849, PH_domain
IPR039026, PH_PKB
IPR017892, Pkinase_C
IPR000719, Prot_kinase_dom
IPR017441, Protein_kinase_ATP_BS
IPR039029, RAC_gamma-like
IPR008271, Ser/Thr_kinase_AS
PANTHERiPTHR24351:SF199, PTHR24351:SF199, 1 hit
PfamiView protein in Pfam
PF00169, PH, 1 hit
PF00069, Pkinase, 1 hit
PF00433, Pkinase_C, 1 hit
SMARTiView protein in SMART
SM00233, PH, 1 hit
SM00133, S_TK_X, 1 hit
SM00220, S_TKc, 1 hit
SUPFAMiSSF56112, SSF56112, 1 hit
PROSITEiView protein in PROSITE
PS51285, AGC_KINASE_CTER, 1 hit
PS50003, PH_DOMAIN, 1 hit
PS00107, PROTEIN_KINASE_ATP, 1 hit
PS50011, PROTEIN_KINASE_DOM, 1 hit
PS00108, PROTEIN_KINASE_ST, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiAKT3_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9Y243
Secondary accession number(s): Q0VAA6
, Q5VTI1, Q5VTI2, Q96QV3, Q9UFP5
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: November 1, 1999
Last modified: May 25, 2022
This is version 219 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Reference proteome

Documents

  1. Human and mouse protein kinases
    Human and mouse protein kinases: classification and index
  2. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  3. Human entries with genetic variants
    List of human entries with genetic variants
  4. Human variants curated from literature reports
    Index of human variants curated from literature reports
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  7. SIMILARITY comments
    Index of protein domains and families
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