UniProtKB - Q9Y242 (TCF19_HUMAN)
Protein
Transcription factor 19
Gene
TCF19
Organism
Homo sapiens (Human)
Status
Functioni
Potential trans-activating factor that could play an important role in the transcription of genes required for the later stages of cell cycle progression.
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 296 – 339 | PHD-typeAdd BLAST | 44 |
GO - Molecular functioni
- DNA-binding transcription factor activity Source: InterPro
- metal ion binding Source: UniProtKB-KW
GO - Biological processi
- regulation of gene expression Source: GO_Central
Keywordsi
Biological process | Transcription, Transcription regulation |
Ligand | Metal-binding, Zinc |
Enzyme and pathway databases
PathwayCommonsi | Q9Y242 |
Names & Taxonomyi
Protein namesi | Recommended name: Transcription factor 19Short name: TCF-19 Alternative name(s): Transcription factor SC1 |
Gene namesi | Name:TCF19 Synonyms:SC1 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
EuPathDBi | HostDB:ENSG00000137310.11 |
HGNCi | HGNC:11629, TCF19 |
MIMi | 600912, gene |
neXtProti | NX_Q9Y242 |
Subcellular locationi
Keywords - Cellular componenti
NucleusPathology & Biotechi
Organism-specific databases
DisGeNETi | 6941 |
OpenTargetsi | ENSG00000137310 |
PharmGKBi | PA36384 |
Miscellaneous databases
Pharosi | Q9Y242, Tbio |
Polymorphism and mutation databases
BioMutai | TCF19 |
DMDMi | 126302606 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000059327 | 1 – 345 | Transcription factor 19Add BLAST | 345 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 78 | PhosphoserineCombined sources | 1 |
Keywords - PTMi
PhosphoproteinProteomic databases
jPOSTi | Q9Y242 |
MassIVEi | Q9Y242 |
MaxQBi | Q9Y242 |
PaxDbi | Q9Y242 |
PeptideAtlasi | Q9Y242 |
PRIDEi | Q9Y242 |
ProteomicsDBi | 85640 |
PTM databases
iPTMneti | Q9Y242 |
PhosphoSitePlusi | Q9Y242 |
Expressioni
Developmental stagei
Growth regulated.
Gene expression databases
Bgeei | ENSG00000137310, Expressed in ventricular zone and 153 other tissues |
ExpressionAtlasi | Q9Y242, baseline and differential |
Genevisiblei | Q9Y242, HS |
Organism-specific databases
HPAi | ENSG00000137310, Tissue enhanced (lymphoid) |
Interactioni
Binary interactionsi
Hide detailsQ9Y242
Protein-protein interaction databases
BioGRIDi | 112801, 29 interactors |
IntActi | Q9Y242, 24 interactors |
MINTi | Q9Y242 |
STRINGi | 9606.ENSP00000365433 |
Miscellaneous databases
RNActi | Q9Y242, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 31 – 88 | FHAPROSITE-ProRule annotationAdd BLAST | 58 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 187 – 300 | Pro-richAdd BLAST | 114 |
Zinc finger
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 296 – 339 | PHD-typeAdd BLAST | 44 |
Keywords - Domaini
Zinc-fingerPhylogenomic databases
eggNOGi | ENOG502RHCY, Eukaryota |
GeneTreei | ENSGT00390000015391 |
HOGENOMi | CLU_041089_0_0_1 |
InParanoidi | Q9Y242 |
OMAi | SGAGCTY |
OrthoDBi | 1106192at2759 |
PhylomeDBi | Q9Y242 |
TreeFami | TF334697 |
Family and domain databases
CDDi | cd00060, FHA, 1 hit cd15609, PHD_TCF19, 1 hit |
Gene3Di | 3.30.40.10, 1 hit |
InterProi | View protein in InterPro IPR000253, FHA_dom IPR008984, SMAD_FHA_dom_sf IPR042803, TCF19 IPR039095, TCF19_PHD IPR019786, Zinc_finger_PHD-type_CS IPR011011, Znf_FYVE_PHD IPR001965, Znf_PHD IPR013083, Znf_RING/FYVE/PHD |
PANTHERi | PTHR15464, PTHR15464, 2 hits |
Pfami | View protein in Pfam PF00498, FHA, 1 hit |
SMARTi | View protein in SMART SM00240, FHA, 1 hit SM00249, PHD, 1 hit |
SUPFAMi | SSF49879, SSF49879, 1 hit SSF57903, SSF57903, 1 hit |
PROSITEi | View protein in PROSITE PS50006, FHA_DOMAIN, 1 hit PS01359, ZF_PHD_1, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show allAlign All
Q9Y242-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MLPCFQLLRI GGGRGGDLYT FHPPAGAGCT YRLGHRADLC DVALRPQQEP
60 70 80 90 100
GLISGIHAEL HAEPRGDDWR VSLEDHSSQG TLVNNVRLPR GHRLELSDGD
110 120 130 140 150
LLTFGPEGPP GTSPSEFYFM FQQVRVKPQD FAAITIPRSR GEARVGAGFR
160 170 180 190 200
PMLPSQGAPQ RPLSTFSPAP KATLILNSIG SLSKLRPQPL TFSPSWGGPK
210 220 230 240 250
SLPVPAPPGE MGTTPSAPPQ RNRRKSVHRV LAELDDESEP PENPPPVLME
260 270 280 290 300
PRKKLRVDKA PLTPTGNRRG RPRKYPVSAP MAPPAVGGGE PCAAPCCCLP
310 320 330 340
QEETVAWVQC DGCDVWFHVA CVGCSIQAAR EADFRCPGCR AGIQT
Computationally mapped potential isoform sequencesi
There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketD2IYK5 | D2IYK5_HUMAN | TCF19 | TCF19 hCG_25998 | 345 | Annotation score: | ||
A0A0G2JIJ7 | A0A0G2JIJ7_HUMAN | TCF19 | TCF19 | 345 | Annotation score: | ||
H0YFN0 | H0YFN0_HUMAN | Transcription factor 19 | TCF19 | 217 | Annotation score: |
Sequence cautioni
The sequence AAB60363 differs from that shown. Reason: Frameshift.Curated
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 27 | A → V in AAB60363 (Ref. 3) Curated | 1 | |
Sequence conflicti | 123 | Q → N in AAB19475 (PubMed:1868030).Curated | 1 | |
Sequence conflicti | 193 | S → T in AAB19475 (PubMed:1868030).Curated | 1 | |
Sequence conflicti | 268 | R → A in AAB60363 (Ref. 3) Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_051604 | 109 | P → S1 PublicationCorresponds to variant dbSNP:rs7750641Ensembl. | 1 | |
Natural variantiVAR_017741 | 211 | M → V8 PublicationsCorresponds to variant dbSNP:rs2073721Ensembl. | 1 | |
Natural variantiVAR_017742 | 241 | P → L3 PublicationsCorresponds to variant dbSNP:rs2073724Ensembl. | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | S53374 mRNA Translation: AAB19475.2 Frameshift. AB029516 Genomic DNA Translation: BAA82324.1 AB029517 Genomic DNA Translation: BAA82325.1 AB029518 Genomic DNA Translation: BAA82326.1 AB029519 Genomic DNA Translation: BAA82327.1 U25826 Genomic DNA Translation: AAB60363.1 Frameshift. BA000025 Genomic DNA Translation: BAB63312.1 AB088113 Genomic DNA Translation: BAC54945.1 AB103619 Genomic DNA Translation: BAF31280.1 AB202105 Genomic DNA Translation: BAE78629.1 BT007247 mRNA Translation: AAP35911.1 AL662833 Genomic DNA No translation available. AL662844 Genomic DNA No translation available. AL773544 Genomic DNA No translation available. BX088580 Genomic DNA No translation available. CR759815 Genomic DNA No translation available. CR388229 Genomic DNA No translation available. CR753819 Genomic DNA No translation available. CR847794 Genomic DNA No translation available. CH471081 Genomic DNA Translation: EAX03363.1 BC002493 mRNA Translation: AAH02493.1 BC033086 mRNA Translation: AAH33086.1 BC044632 mRNA Translation: AAH44632.1 |
CCDSi | CCDS43446.1 |
PIRi | A61188 |
RefSeqi | NP_001070979.1, NM_001077511.1 NP_001305837.1, NM_001318908.1 NP_009040.2, NM_007109.2 |
Genome annotation databases
Ensembli | ENST00000376255; ENSP00000365431; ENSG00000137310 ENST00000376257; ENSP00000365433; ENSG00000137310 |
GeneIDi | 6941 |
KEGGi | hsa:6941 |
UCSCi | uc003nss.4, human |
Keywords - Coding sequence diversityi
PolymorphismSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | S53374 mRNA Translation: AAB19475.2 Frameshift. AB029516 Genomic DNA Translation: BAA82324.1 AB029517 Genomic DNA Translation: BAA82325.1 AB029518 Genomic DNA Translation: BAA82326.1 AB029519 Genomic DNA Translation: BAA82327.1 U25826 Genomic DNA Translation: AAB60363.1 Frameshift. BA000025 Genomic DNA Translation: BAB63312.1 AB088113 Genomic DNA Translation: BAC54945.1 AB103619 Genomic DNA Translation: BAF31280.1 AB202105 Genomic DNA Translation: BAE78629.1 BT007247 mRNA Translation: AAP35911.1 AL662833 Genomic DNA No translation available. AL662844 Genomic DNA No translation available. AL773544 Genomic DNA No translation available. BX088580 Genomic DNA No translation available. CR759815 Genomic DNA No translation available. CR388229 Genomic DNA No translation available. CR753819 Genomic DNA No translation available. CR847794 Genomic DNA No translation available. CH471081 Genomic DNA Translation: EAX03363.1 BC002493 mRNA Translation: AAH02493.1 BC033086 mRNA Translation: AAH33086.1 BC044632 mRNA Translation: AAH44632.1 |
CCDSi | CCDS43446.1 |
PIRi | A61188 |
RefSeqi | NP_001070979.1, NM_001077511.1 NP_001305837.1, NM_001318908.1 NP_009040.2, NM_007109.2 |
3D structure databases
SMRi | Q9Y242 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 112801, 29 interactors |
IntActi | Q9Y242, 24 interactors |
MINTi | Q9Y242 |
STRINGi | 9606.ENSP00000365433 |
PTM databases
iPTMneti | Q9Y242 |
PhosphoSitePlusi | Q9Y242 |
Polymorphism and mutation databases
BioMutai | TCF19 |
DMDMi | 126302606 |
Proteomic databases
jPOSTi | Q9Y242 |
MassIVEi | Q9Y242 |
MaxQBi | Q9Y242 |
PaxDbi | Q9Y242 |
PeptideAtlasi | Q9Y242 |
PRIDEi | Q9Y242 |
ProteomicsDBi | 85640 |
Protocols and materials databases
Antibodypediai | 26851, 212 antibodies |
DNASUi | 6941 |
Genome annotation databases
Ensembli | ENST00000376255; ENSP00000365431; ENSG00000137310 ENST00000376257; ENSP00000365433; ENSG00000137310 |
GeneIDi | 6941 |
KEGGi | hsa:6941 |
UCSCi | uc003nss.4, human |
Organism-specific databases
CTDi | 6941 |
DisGeNETi | 6941 |
EuPathDBi | HostDB:ENSG00000137310.11 |
GeneCardsi | TCF19 |
HGNCi | HGNC:11629, TCF19 |
HPAi | ENSG00000137310, Tissue enhanced (lymphoid) |
MIMi | 600912, gene |
neXtProti | NX_Q9Y242 |
OpenTargetsi | ENSG00000137310 |
PharmGKBi | PA36384 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | ENOG502RHCY, Eukaryota |
GeneTreei | ENSGT00390000015391 |
HOGENOMi | CLU_041089_0_0_1 |
InParanoidi | Q9Y242 |
OMAi | SGAGCTY |
OrthoDBi | 1106192at2759 |
PhylomeDBi | Q9Y242 |
TreeFami | TF334697 |
Enzyme and pathway databases
PathwayCommonsi | Q9Y242 |
Miscellaneous databases
BioGRID-ORCSi | 6941, 2 hits in 850 CRISPR screens |
ChiTaRSi | TCF19, human |
GeneWikii | TCF19 |
GenomeRNAii | 6941 |
Pharosi | Q9Y242, Tbio |
PROi | PR:Q9Y242 |
RNActi | Q9Y242, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000137310, Expressed in ventricular zone and 153 other tissues |
ExpressionAtlasi | Q9Y242, baseline and differential |
Genevisiblei | Q9Y242, HS |
Family and domain databases
CDDi | cd00060, FHA, 1 hit cd15609, PHD_TCF19, 1 hit |
Gene3Di | 3.30.40.10, 1 hit |
InterProi | View protein in InterPro IPR000253, FHA_dom IPR008984, SMAD_FHA_dom_sf IPR042803, TCF19 IPR039095, TCF19_PHD IPR019786, Zinc_finger_PHD-type_CS IPR011011, Znf_FYVE_PHD IPR001965, Znf_PHD IPR013083, Znf_RING/FYVE/PHD |
PANTHERi | PTHR15464, PTHR15464, 2 hits |
Pfami | View protein in Pfam PF00498, FHA, 1 hit |
SMARTi | View protein in SMART SM00240, FHA, 1 hit SM00249, PHD, 1 hit |
SUPFAMi | SSF49879, SSF49879, 1 hit SSF57903, SSF57903, 1 hit |
PROSITEi | View protein in PROSITE PS50006, FHA_DOMAIN, 1 hit PS01359, ZF_PHD_1, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | TCF19_HUMAN | |
Accessioni | Q9Y242Primary (citable) accession number: Q9Y242 Secondary accession number(s): A6NCT8 Q9UBH7 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | February 16, 2004 |
Last sequence update: | February 20, 2007 | |
Last modified: | December 2, 2020 | |
This is version 167 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human chromosome 6
Human chromosome 6: entries, gene names and cross-references to MIM - Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations