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Protein

Transcription factor 19

Gene

TCF19

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Potential trans-activating factor that could play an important role in the transcription of genes required for the later stages of cell cycle progression.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri296 – 339PHD-typeAdd BLAST44

GO - Molecular functioni

  • DNA-binding transcription factor activity Source: ProtInc
  • metal ion binding Source: UniProtKB-KW

GO - Biological processi

Keywordsi

Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Transcription factor 19
Short name:
TCF-19
Alternative name(s):
Transcription factor SC1
Gene namesi
Name:TCF19
Synonyms:SC1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 6

Organism-specific databases

EuPathDBiHostDB:ENSG00000137310.11
HGNCiHGNC:11629 TCF19
MIMi600912 gene
neXtProtiNX_Q9Y242

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi6941
OpenTargetsiENSG00000137310
PharmGKBiPA36384

Polymorphism and mutation databases

BioMutaiTCF19
DMDMi126302606

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000593271 – 345Transcription factor 19Add BLAST345

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei78PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ9Y242
PaxDbiQ9Y242
PeptideAtlasiQ9Y242
PRIDEiQ9Y242
ProteomicsDBi85640

PTM databases

iPTMnetiQ9Y242
PhosphoSitePlusiQ9Y242

Expressioni

Developmental stagei

Growth regulated.

Gene expression databases

BgeeiENSG00000137310 Expressed in 130 organ(s), highest expression level in mucosa of transverse colon
ExpressionAtlasiQ9Y242 baseline and differential
GenevisibleiQ9Y242 HS

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
GOLGA2Q083793EBI-7413767,EBI-618309

Protein-protein interaction databases

BioGridi112801, 13 interactors
IntActiQ9Y242, 16 interactors
MINTiQ9Y242
STRINGi9606.ENSP00000365431

Structurei

3D structure databases

ProteinModelPortaliQ9Y242
SMRiQ9Y242
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini31 – 88FHAPROSITE-ProRule annotationAdd BLAST58

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi187 – 300Pro-richAdd BLAST114

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri296 – 339PHD-typeAdd BLAST44

Keywords - Domaini

Zinc-finger

Phylogenomic databases

eggNOGiENOG410IXZZ Eukaryota
ENOG4111J5W LUCA
GeneTreeiENSGT00390000015391
HOVERGENiHBG054343
InParanoidiQ9Y242
OMAiADFHCGC
OrthoDBiEOG091G05D2
PhylomeDBiQ9Y242
TreeFamiTF334697

Family and domain databases

CDDicd00060 FHA, 1 hit
cd15609 PHD_TCF19, 1 hit
Gene3Di3.30.40.10, 1 hit
InterProiView protein in InterPro
IPR000253 FHA_dom
IPR008984 SMAD_FHA_dom_sf
IPR039095 TCF19_PHD
IPR019786 Zinc_finger_PHD-type_CS
IPR011011 Znf_FYVE_PHD
IPR001965 Znf_PHD
IPR013083 Znf_RING/FYVE/PHD
PfamiView protein in Pfam
PF00498 FHA, 1 hit
SMARTiView protein in SMART
SM00240 FHA, 1 hit
SM00249 PHD, 1 hit
SUPFAMiSSF49879 SSF49879, 1 hit
SSF57903 SSF57903, 1 hit
PROSITEiView protein in PROSITE
PS50006 FHA_DOMAIN, 1 hit
PS01359 ZF_PHD_1, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show allAlign All

Q9Y242-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MLPCFQLLRI GGGRGGDLYT FHPPAGAGCT YRLGHRADLC DVALRPQQEP
60 70 80 90 100
GLISGIHAEL HAEPRGDDWR VSLEDHSSQG TLVNNVRLPR GHRLELSDGD
110 120 130 140 150
LLTFGPEGPP GTSPSEFYFM FQQVRVKPQD FAAITIPRSR GEARVGAGFR
160 170 180 190 200
PMLPSQGAPQ RPLSTFSPAP KATLILNSIG SLSKLRPQPL TFSPSWGGPK
210 220 230 240 250
SLPVPAPPGE MGTTPSAPPQ RNRRKSVHRV LAELDDESEP PENPPPVLME
260 270 280 290 300
PRKKLRVDKA PLTPTGNRRG RPRKYPVSAP MAPPAVGGGE PCAAPCCCLP
310 320 330 340
QEETVAWVQC DGCDVWFHVA CVGCSIQAAR EADFRCPGCR AGIQT
Length:345
Mass (Da):37,184
Last modified:February 20, 2007 - v2
Checksum:iB5730936A842B83A
GO

Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
D2IYK5D2IYK5_HUMAN
TCF19
TCF19 hCG_25998
345Annotation score:
A0A0G2JIJ7A0A0G2JIJ7_HUMAN
TCF19
TCF19
345Annotation score:
H0YFN0H0YFN0_HUMAN
Transcription factor 19
TCF19
217Annotation score:

Sequence cautioni

The sequence AAB60363 differs from that shown. Reason: Frameshift at positions 288, 290 and 291.Curated
The sequence AAB60363 differs from that shown. Reason: Frameshift at position 288.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti27A → V in AAB60363 (Ref. 3) Curated1
Sequence conflicti123Q → N in AAB19475 (PubMed:1868030).Curated1
Sequence conflicti193S → T in AAB19475 (PubMed:1868030).Curated1
Sequence conflicti268R → A in AAB60363 (Ref. 3) Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_051604109P → S1 PublicationCorresponds to variant dbSNP:rs7750641Ensembl.1
Natural variantiVAR_017741211M → V8 PublicationsCorresponds to variant dbSNP:rs2073721Ensembl.1
Natural variantiVAR_017742241P → L3 PublicationsCorresponds to variant dbSNP:rs2073724Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
S53374 mRNA Translation: AAB19475.2 Frameshift.
AB029516 Genomic DNA Translation: BAA82324.1
AB029517 Genomic DNA Translation: BAA82325.1
AB029518 Genomic DNA Translation: BAA82326.1
AB029519 Genomic DNA Translation: BAA82327.1
U25826 Genomic DNA Translation: AAB60363.1 Frameshift.
BA000025 Genomic DNA Translation: BAB63312.1
AB088113 Genomic DNA Translation: BAC54945.1
AB103619 Genomic DNA Translation: BAF31280.1
AB202105 Genomic DNA Translation: BAE78629.1
BT007247 mRNA Translation: AAP35911.1
AL662833 Genomic DNA No translation available.
AL662844 Genomic DNA No translation available.
AL773544 Genomic DNA No translation available.
BX088580 Genomic DNA No translation available.
CR759815 Genomic DNA No translation available.
CR388229 Genomic DNA No translation available.
CR753819 Genomic DNA No translation available.
CR847794 Genomic DNA No translation available.
CH471081 Genomic DNA Translation: EAX03363.1
BC002493 mRNA Translation: AAH02493.1
BC033086 mRNA Translation: AAH33086.1
BC044632 mRNA Translation: AAH44632.1
CCDSiCCDS43446.1
PIRiA61188
RefSeqiNP_001070979.1, NM_001077511.1
NP_001305837.1, NM_001318908.1
NP_009040.2, NM_007109.2
UniGeneiHs.584807

Genome annotation databases

EnsembliENST00000376255; ENSP00000365431; ENSG00000137310
ENST00000376257; ENSP00000365433; ENSG00000137310
GeneIDi6941
KEGGihsa:6941
UCSCiuc003nss.4 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
S53374 mRNA Translation: AAB19475.2 Frameshift.
AB029516 Genomic DNA Translation: BAA82324.1
AB029517 Genomic DNA Translation: BAA82325.1
AB029518 Genomic DNA Translation: BAA82326.1
AB029519 Genomic DNA Translation: BAA82327.1
U25826 Genomic DNA Translation: AAB60363.1 Frameshift.
BA000025 Genomic DNA Translation: BAB63312.1
AB088113 Genomic DNA Translation: BAC54945.1
AB103619 Genomic DNA Translation: BAF31280.1
AB202105 Genomic DNA Translation: BAE78629.1
BT007247 mRNA Translation: AAP35911.1
AL662833 Genomic DNA No translation available.
AL662844 Genomic DNA No translation available.
AL773544 Genomic DNA No translation available.
BX088580 Genomic DNA No translation available.
CR759815 Genomic DNA No translation available.
CR388229 Genomic DNA No translation available.
CR753819 Genomic DNA No translation available.
CR847794 Genomic DNA No translation available.
CH471081 Genomic DNA Translation: EAX03363.1
BC002493 mRNA Translation: AAH02493.1
BC033086 mRNA Translation: AAH33086.1
BC044632 mRNA Translation: AAH44632.1
CCDSiCCDS43446.1
PIRiA61188
RefSeqiNP_001070979.1, NM_001077511.1
NP_001305837.1, NM_001318908.1
NP_009040.2, NM_007109.2
UniGeneiHs.584807

3D structure databases

ProteinModelPortaliQ9Y242
SMRiQ9Y242
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi112801, 13 interactors
IntActiQ9Y242, 16 interactors
MINTiQ9Y242
STRINGi9606.ENSP00000365431

PTM databases

iPTMnetiQ9Y242
PhosphoSitePlusiQ9Y242

Polymorphism and mutation databases

BioMutaiTCF19
DMDMi126302606

Proteomic databases

MaxQBiQ9Y242
PaxDbiQ9Y242
PeptideAtlasiQ9Y242
PRIDEiQ9Y242
ProteomicsDBi85640

Protocols and materials databases

DNASUi6941
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000376255; ENSP00000365431; ENSG00000137310
ENST00000376257; ENSP00000365433; ENSG00000137310
GeneIDi6941
KEGGihsa:6941
UCSCiuc003nss.4 human

Organism-specific databases

CTDi6941
DisGeNETi6941
EuPathDBiHostDB:ENSG00000137310.11
GeneCardsiTCF19
H-InvDBiHIX0005713
HGNCiHGNC:11629 TCF19
MIMi600912 gene
neXtProtiNX_Q9Y242
OpenTargetsiENSG00000137310
PharmGKBiPA36384
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IXZZ Eukaryota
ENOG4111J5W LUCA
GeneTreeiENSGT00390000015391
HOVERGENiHBG054343
InParanoidiQ9Y242
OMAiADFHCGC
OrthoDBiEOG091G05D2
PhylomeDBiQ9Y242
TreeFamiTF334697

Miscellaneous databases

ChiTaRSiTCF19 human
GeneWikiiTCF19
GenomeRNAii6941
PROiPR:Q9Y242
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000137310 Expressed in 130 organ(s), highest expression level in mucosa of transverse colon
ExpressionAtlasiQ9Y242 baseline and differential
GenevisibleiQ9Y242 HS

Family and domain databases

CDDicd00060 FHA, 1 hit
cd15609 PHD_TCF19, 1 hit
Gene3Di3.30.40.10, 1 hit
InterProiView protein in InterPro
IPR000253 FHA_dom
IPR008984 SMAD_FHA_dom_sf
IPR039095 TCF19_PHD
IPR019786 Zinc_finger_PHD-type_CS
IPR011011 Znf_FYVE_PHD
IPR001965 Znf_PHD
IPR013083 Znf_RING/FYVE/PHD
PfamiView protein in Pfam
PF00498 FHA, 1 hit
SMARTiView protein in SMART
SM00240 FHA, 1 hit
SM00249 PHD, 1 hit
SUPFAMiSSF49879 SSF49879, 1 hit
SSF57903 SSF57903, 1 hit
PROSITEiView protein in PROSITE
PS50006 FHA_DOMAIN, 1 hit
PS01359 ZF_PHD_1, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiTCF19_HUMAN
AccessioniPrimary (citable) accession number: Q9Y242
Secondary accession number(s): A6NCT8
, B0UY11, Q0EFA8, Q13176, Q15967, Q5SQ89, Q5STD6, Q5STF5, Q9BUM2, Q9UBH7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 16, 2004
Last sequence update: February 20, 2007
Last modified: November 7, 2018
This is version 151 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  2. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
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Main funding by: National Institutes of Health

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