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Entry version 165 (13 Nov 2019)
Sequence version 1 (01 Nov 1999)
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Protein

Peptidyl-prolyl cis-trans isomerase NIMA-interacting 4

Gene

PIN4

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Isoform 1 is involved as a ribosomal RNA processing factor in ribosome biogenesis. Binds to tightly bent AT-rich stretches of double-stranded DNA.1 Publication
Isoform 2 binds to double-stranded DNA.1 Publication

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDNA-binding, Isomerase, Rotamase

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Peptidyl-prolyl cis-trans isomerase NIMA-interacting 4 (EC:5.2.1.8)
Alternative name(s):
Parvulin-14
Short name:
Par14
Short name:
hPar14
Parvulin-17
Short name:
Par17
Short name:
hPar17
Peptidyl-prolyl cis-trans isomerase Pin4
Short name:
PPIase Pin4
Peptidyl-prolyl cis/trans isomerase EPVH
Short name:
hEPVH
Rotamase Pin4
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:PIN4
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome X

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:8992 PIN4

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
300252 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q9Y237

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton, Mitochondrion, Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi19S → A: Abolishes phosphorylation and reduces strongly nuclear localization. 1 Publication1
Mutagenesisi19S → E: Does not abolish nuclear localization and reduces DNA-binding ability. 1 Publication1

Organism-specific databases

DisGeNET

More...
DisGeNETi
5303

Open Targets

More...
OpenTargetsi
ENSG00000102309

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA33324

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q9Y237

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...
ChEMBLi
CHEMBL4923

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
PIN4

Domain mapping of disease mutations (DMDM)

More...
DMDMi
20139299

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001934381 – 131Peptidyl-prolyl cis-trans isomerase NIMA-interacting 4Add BLAST131

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei19Phosphoserine; by CK21 Publication1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Phosphorylated. Isoform 1 phosphorylation occurs both in the nucleus and the cytoplasm. Isoform 1 phosphorylation at Ser-19 does not affect its PPIase activity but is required for nuclear localization, and the dephosphorylation is a prerequisite for the binding to DNA. The unphosphorylated isoform 1 associates with the pre-rRNP complexes in the nucleus.2 Publications
Isoform 2 is sumoylated with SUMO2 and SUMO3.1 Publication

Keywords - PTMi

Phosphoprotein, Ubl conjugation

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q9Y237

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q9Y237

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
Q9Y237

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q9Y237

PeptideAtlas

More...
PeptideAtlasi
Q9Y237

PRoteomics IDEntifications database

More...
PRIDEi
Q9Y237

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
25719
85631 [Q9Y237-1]
85632 [Q9Y237-2]

Consortium for Top Down Proteomics

More...
TopDownProteomicsi
Q9Y237-1 [Q9Y237-1]
Q9Y237-2 [Q9Y237-2]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q9Y237

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q9Y237

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Isoform 2 is much more stable than isoform 1 (at protein level). Ubiquitous. Isoform 1 and isoform 2 are expressed in kidney, liver, blood vessel, brain, mammary gland, skeletal muscle, small intestine and submandibularis. Isoform 1 transcripts are much more abundant than isoform 2 in each tissue analyzed.3 Publications

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000102309 Expressed in 237 organ(s), highest expression level in endometrium

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q9Y237 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q9Y237 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA054483
HPA064504

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Isoform 1 is found in pre-ribosomal ribonucleoprotein (pre-rRNP) complexes.

By similarity

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
111320, 38 interactors

CORUM comprehensive resource of mammalian protein complexes

More...
CORUMi
Q9Y237

Database of interacting proteins

More...
DIPi
DIP-50838N

Protein interaction database and analysis system

More...
IntActi
Q9Y237, 18 interactors

Molecular INTeraction database

More...
MINTi
Q9Y237

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000362773

Chemistry databases

BindingDB database of measured binding affinities

More...
BindingDBi
Q9Y237

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1131
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q9Y237

Database of comparative protein structure models

More...
ModBasei
Search...

Protein Data Bank in Europe - Knowledge Base

More...
PDBe-KBi
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...
EvolutionaryTracei
Q9Y237

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini35 – 129PpiCPROSITE-ProRule annotationAdd BLAST95

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 41Necessary for association with the pre-rRNP complexesAdd BLAST41
Regioni1 – 25Necessary for nuclear localization and DNA-bindingAdd BLAST25

<p>This subsection of the ‘Family and domains’ section provides general information on the biological role of a domain. The term ‘domain’ is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The PPIase domain enhances mitochondrial targeting.

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG3258 Eukaryota
COG0760 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00510000047029

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q9Y237

KEGG Orthology (KO)

More...
KOi
K09579

Identification of Orthologs from Complete Genome Data

More...
OMAi
LGWKTKG

Database of Orthologous Groups

More...
OrthoDBi
1413648at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q9Y237

TreeFam database of animal gene trees

More...
TreeFami
TF101102

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR000297 PPIase_PpiC

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50198 PPIC_PPIASE_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 3 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative promoter usage. AlignAdd to basket

This entry has 3 described isoforms and 6 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q9Y237-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MPPKGKSGSG KAGKGGAASG SDSADKKAQG PKGGGNAVKV RHILCEKHGK
60 70 80 90 100
IMEAMEKLKS GMRFNEVAAQ YSEDKARQGG DLGWMTRGSM VGPFQEAAFA
110 120 130
LPVSGMDKPV FTDPPVKTKF GYHIIMVEGR K
Length:131
Mass (Da):13,810
Last modified:November 1, 1999 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i787C15BDB0701258
GO
Isoform 2 (identifier: Q9Y237-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-1: M → MPMAGLLKGLVRQLERFSVQQQASKM

Note: The first 25 amino acids are sufficient for mitochondrial targeting.2 Publications
Show »
Length:156
Mass (Da):16,608
Checksum:i8D4668D3ADB24740
GO
Isoform 3 (identifier: Q9Y237-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-1: M → MPMAGLLKGLVRQLERFSVQQQASKM
     80-131: GDLGWMTRGS...YHIIMVEGRK → IPSLQQHAGHHRDLRSTLISLVSYLQTTP

Note: No experimental confirmation available.
Show »
Length:133
Mass (Da):14,179
Checksum:iB217F63257D92D65
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 6 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H0Y8P6H0Y8P6_HUMAN
Peptidyl-prolyl cis-trans isomerase...
PIN4
108Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
J3KMW3J3KMW3_HUMAN
Peptidyl-prolyl cis-trans isomerase...
PIN4
86Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0Y4T6H0Y4T6_HUMAN
Peptidyl-prolyl cis-trans isomerase...
PIN4
84Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0Y610H0Y610_HUMAN
Peptidyl-prolyl cis-trans isomerase...
PIN4
95Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
D6RFY5D6RFY5_HUMAN
Peptidyl-prolyl cis-trans isomerase...
PIN4
81Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A494C021A0A494C021_HUMAN
Peptidyl-prolyl cis-trans isomerase...
PIN4
117Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAH05234 differs from that shown. Reason: Erroneous initiation.Curated
The sequence AAH70288 differs from that shown. Reason: Erroneous initiation.Curated
The sequence AAI04654 differs from that shown. Reason: Erroneous initiation.Curated
The sequence AAI11395 differs from that shown. Reason: Erroneous initiation. Extended N-terminus.Curated
The sequence BAG54532 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Isoform 2 (identifier: Q9Y237-2)
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural varianti16R → Q2 PublicationsCorresponds to variant dbSNP:rs6525589Ensembl.1
Natural varianti18S → R2 PublicationsCorresponds to variant dbSNP:rs7058353Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0377541M → MPMAGLLKGLVRQLERFSVQ QQASKM in isoform 2 and isoform 3. 2 Publications1
Alternative sequenceiVSP_04612280 – 131GDLGW…VEGRK → IPSLQQHAGHHRDLRSTLIS LVSYLQTTP in isoform 3. 1 PublicationAdd BLAST52

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF143096 mRNA Translation: AAD27893.1
AB009690 mRNA Translation: BAA82320.1
AL135749 Genomic DNA No translation available.
BX119917 Genomic DNA No translation available.
BC005234 mRNA Translation: AAH05234.2 Different initiation.
BC070288 mRNA Translation: AAH70288.1 Different initiation.
BC093700 mRNA Translation: AAH93700.1
BC104653 mRNA Translation: AAI04654.1 Different initiation.
BC111394 mRNA Translation: AAI11395.1 Different initiation.
BC112281 mRNA Translation: AAI12282.1
AM420633 Genomic DNA Translation: CAM12362.1
AK127605 mRNA Translation: BAG54532.1 Different initiation.

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS14417.1 [Q9Y237-1]
CCDS55447.1 [Q9Y237-3]

NCBI Reference Sequences

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RefSeqi
NP_001164218.1, NM_001170747.1 [Q9Y237-3]
NP_006214.2, NM_006223.3 [Q9Y237-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENST00000373669; ENSP00000362773; ENSG00000102309 [Q9Y237-1]
ENST00000423432; ENSP00000409154; ENSG00000102309 [Q9Y237-3]
ENST00000664196; ENSP00000499466; ENSG00000102309 [Q9Y237-2]

Database of genes from NCBI RefSeq genomes

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GeneIDi
5303

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:5303

UCSC genome browser

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UCSCi
uc004eam.4 human [Q9Y237-1]

Keywords - Coding sequence diversityi

Alternative promoter usage, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF143096 mRNA Translation: AAD27893.1
AB009690 mRNA Translation: BAA82320.1
AL135749 Genomic DNA No translation available.
BX119917 Genomic DNA No translation available.
BC005234 mRNA Translation: AAH05234.2 Different initiation.
BC070288 mRNA Translation: AAH70288.1 Different initiation.
BC093700 mRNA Translation: AAH93700.1
BC104653 mRNA Translation: AAI04654.1 Different initiation.
BC111394 mRNA Translation: AAI11395.1 Different initiation.
BC112281 mRNA Translation: AAI12282.1
AM420633 Genomic DNA Translation: CAM12362.1
AK127605 mRNA Translation: BAG54532.1 Different initiation.
CCDSiCCDS14417.1 [Q9Y237-1]
CCDS55447.1 [Q9Y237-3]
RefSeqiNP_001164218.1, NM_001170747.1 [Q9Y237-3]
NP_006214.2, NM_006223.3 [Q9Y237-1]

3D structure databases

Select the link destinations:

Protein Data Bank Europe

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PDBei

Protein Data Bank RCSB

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RCSB PDBi

Protein Data Bank Japan

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PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1EQ3NMR-A36-131[»]
1FJDNMR-A28-131[»]
3UI4X-ray0.80A36-131[»]
3UI5X-ray1.40A36-131[»]
3UI6X-ray0.89A36-131[»]
SMRiQ9Y237
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGridi111320, 38 interactors
CORUMiQ9Y237
DIPiDIP-50838N
IntActiQ9Y237, 18 interactors
MINTiQ9Y237
STRINGi9606.ENSP00000362773

Chemistry databases

BindingDBiQ9Y237
ChEMBLiCHEMBL4923

PTM databases

iPTMnetiQ9Y237
PhosphoSitePlusiQ9Y237

Polymorphism and mutation databases

BioMutaiPIN4
DMDMi20139299

Proteomic databases

EPDiQ9Y237
jPOSTiQ9Y237
MassIVEiQ9Y237
PaxDbiQ9Y237
PeptideAtlasiQ9Y237
PRIDEiQ9Y237
ProteomicsDBi25719
85631 [Q9Y237-1]
85632 [Q9Y237-2]
TopDownProteomicsiQ9Y237-1 [Q9Y237-1]
Q9Y237-2 [Q9Y237-2]

Protocols and materials databases

The DNASU plasmid repository

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DNASUi
5303

Genome annotation databases

EnsembliENST00000373669; ENSP00000362773; ENSG00000102309 [Q9Y237-1]
ENST00000423432; ENSP00000409154; ENSG00000102309 [Q9Y237-3]
ENST00000664196; ENSP00000499466; ENSG00000102309 [Q9Y237-2]
GeneIDi5303
KEGGihsa:5303
UCSCiuc004eam.4 human [Q9Y237-1]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
5303
DisGeNETi5303

GeneCards: human genes, protein and diseases

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GeneCardsi
PIN4
HGNCiHGNC:8992 PIN4
HPAiHPA054483
HPA064504
MIMi300252 gene
neXtProtiNX_Q9Y237
OpenTargetsiENSG00000102309
PharmGKBiPA33324

GenAtlas: human gene database

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GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG3258 Eukaryota
COG0760 LUCA
GeneTreeiENSGT00510000047029
InParanoidiQ9Y237
KOiK09579
OMAiLGWKTKG
OrthoDBi1413648at2759
PhylomeDBiQ9Y237
TreeFamiTF101102

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
PIN4 human
EvolutionaryTraceiQ9Y237

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
PIN4

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
5303
PharosiQ9Y237

Protein Ontology

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PROi
PR:Q9Y237

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
Search...

Gene expression databases

BgeeiENSG00000102309 Expressed in 237 organ(s), highest expression level in endometrium
ExpressionAtlasiQ9Y237 baseline and differential
GenevisibleiQ9Y237 HS

Family and domain databases

InterProiView protein in InterPro
IPR000297 PPIase_PpiC
PROSITEiView protein in PROSITE
PS50198 PPIC_PPIASE_2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiPIN4_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9Y237
Secondary accession number(s): A8E0G6
, B3KXM0, F5H1P5, Q0D2H3, Q3MHV0, Q52M21, Q5HYW6, Q6IRW4
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 23, 2002
Last sequence update: November 1, 1999
Last modified: November 13, 2019
This is version 165 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome X
    Human chromosome X: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
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