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Protein

C->U-editing enzyme APOBEC-2

Gene

APOBEC2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Probable C to U editing enzyme whose physiological substrate is not yet known. Does not display detectable apoB mRNA editing. Has a low intrinsic cytidine deaminase activity. May play a role in the epigenetic regulation of gene expression through the process of active DNA demethylation.2 Publications

Catalytic activityi

Cytosine(6666) in apolipoprotein B mRNA + H2O = uracil(6666) in apolipoprotein B mRNA + NH3.1 Publication

Cofactori

Zn2+1 PublicationNote: Binds 1 Zn2+ ion per subunit.1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi60Zinc; catalytic1 Publication1
Metal bindingi98Zinc; catalytic1 Publication1
Active sitei100Proton donor1 Publication1
Metal bindingi128Zinc; catalytic1 Publication1
Metal bindingi131Zinc; catalytic1 Publication1

GO - Molecular functioni

  • cytidine deaminase activity Source: MGI
  • identical protein binding Source: IntAct
  • RNA binding Source: GO_Central
  • zinc ion binding Source: InterPro

GO - Biological processi

Keywordsi

Molecular functionHydrolase
Biological processmRNA processing
LigandMetal-binding, Zinc

Enzyme and pathway databases

ReactomeiR-HSA-72200 mRNA Editing: C to U Conversion
R-HSA-75094 Formation of the Editosome

Names & Taxonomyi

Protein namesi
Recommended name:
C->U-editing enzyme APOBEC-2 (EC:3.5.4.361 Publication)
Alternative name(s):
mRNA(cytosine(6666)) deaminase 2
Gene namesi
Name:APOBEC2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 6

Organism-specific databases

EuPathDBiHostDB:ENSG00000124701.5
HGNCiHGNC:605 APOBEC2
MIMi604797 gene
neXtProtiNX_Q9Y235

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Pathology & Biotechi

Organism-specific databases

DisGeNETi10930
OpenTargetsiENSG00000124701
PharmGKBiPA24890

Polymorphism and mutation databases

BioMutaiAPOBEC2
DMDMi23396446

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001717491 – 224C->U-editing enzyme APOBEC-2Add BLAST224

Proteomic databases

PaxDbiQ9Y235
PeptideAtlasiQ9Y235
PRIDEiQ9Y235
ProteomicsDBi85628

PTM databases

iPTMnetiQ9Y235
PhosphoSitePlusiQ9Y235

Expressioni

Tissue specificityi

Expressed exclusively in heart and skeletal muscle.

Gene expression databases

BgeeiENSG00000124701 Expressed in 134 organ(s), highest expression level in skeletal muscle tissue of rectus abdominis
CleanExiHS_APOBEC2
GenevisibleiQ9Y235 HS

Organism-specific databases

HPAiHPA014252
HPA017957

Interactioni

Subunit structurei

Homotetramer.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
itself2EBI-15616888,EBI-15616888

GO - Molecular functioni

Protein-protein interaction databases

BioGridi116133, 1 interactor
DIPiDIP-60263N
STRINGi9606.ENSP00000244669

Structurei

Secondary structure

1224
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliQ9Y235
SMRiQ9Y235
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ9Y235

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini64 – 169CMP/dCMP-type deaminasePROSITE-ProRule annotationAdd BLAST106

Sequence similaritiesi

Phylogenomic databases

eggNOGiENOG410IX13 Eukaryota
ENOG4111K4B LUCA
GeneTreeiENSGT00530000062933
HOGENOMiHOG000033754
HOVERGENiHBG107155
KOiK18772
OMAiDEHAGAH
OrthoDBiEOG091G0JNJ
PhylomeDBiQ9Y235
TreeFamiTF331356

Family and domain databases

InterProiView protein in InterPro
IPR013158 APOBEC_N
IPR002125 CMP_dCMP_dom
IPR016193 Cytidine_deaminase-like
PfamiView protein in Pfam
PF08210 APOBEC_N, 1 hit
SUPFAMiSSF53927 SSF53927, 1 hit
PROSITEiView protein in PROSITE
PS51747 CYT_DCMP_DEAMINASES_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q9Y235-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAQKEEAAVA TEAASQNGED LENLDDPEKL KELIELPPFE IVTGERLPAN
60 70 80 90 100
FFKFQFRNVE YSSGRNKTFL CYVVEAQGKG GQVQASRGYL EDEHAAAHAE
110 120 130 140 150
EAFFNTILPA FDPALRYNVT WYVSSSPCAA CADRIIKTLS KTKNLRLLIL
160 170 180 190 200
VGRLFMWEEP EIQAALKKLK EAGCKLRIMK PQDFEYVWQN FVEQEEGESK
210 220
AFQPWEDIQE NFLYYEEKLA DILK
Length:224
Mass (Da):25,703
Last modified:November 1, 1999 - v1
Checksum:iCA0905AFAA8C8FA1
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_024406136I → T1 PublicationCorresponds to variant dbSNP:rs2076472Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF161698 mRNA Translation: AAD45360.1
AK223461 mRNA Translation: BAD97181.1
AK313288 mRNA Translation: BAG36096.1
AL031778 Genomic DNA No translation available.
CH471081 Genomic DNA Translation: EAX04009.1
BC047767 mRNA Translation: AAH47767.1
BC069688 mRNA Translation: AAH69688.1
BC069764 mRNA Translation: AAH69764.1
CCDSiCCDS4848.1
RefSeqiNP_006780.1, NM_006789.3
UniGeneiHs.555915

Genome annotation databases

EnsembliENST00000244669; ENSP00000244669; ENSG00000124701
GeneIDi10930
KEGGihsa:10930
UCSCiuc003opl.4 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF161698 mRNA Translation: AAD45360.1
AK223461 mRNA Translation: BAD97181.1
AK313288 mRNA Translation: BAG36096.1
AL031778 Genomic DNA No translation available.
CH471081 Genomic DNA Translation: EAX04009.1
BC047767 mRNA Translation: AAH47767.1
BC069688 mRNA Translation: AAH69688.1
BC069764 mRNA Translation: AAH69764.1
CCDSiCCDS4848.1
RefSeqiNP_006780.1, NM_006789.3
UniGeneiHs.555915

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2NYTX-ray2.50A/B/C/D41-224[»]
ProteinModelPortaliQ9Y235
SMRiQ9Y235
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi116133, 1 interactor
DIPiDIP-60263N
STRINGi9606.ENSP00000244669

PTM databases

iPTMnetiQ9Y235
PhosphoSitePlusiQ9Y235

Polymorphism and mutation databases

BioMutaiAPOBEC2
DMDMi23396446

Proteomic databases

PaxDbiQ9Y235
PeptideAtlasiQ9Y235
PRIDEiQ9Y235
ProteomicsDBi85628

Protocols and materials databases

DNASUi10930
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000244669; ENSP00000244669; ENSG00000124701
GeneIDi10930
KEGGihsa:10930
UCSCiuc003opl.4 human

Organism-specific databases

CTDi10930
DisGeNETi10930
EuPathDBiHostDB:ENSG00000124701.5
GeneCardsiAPOBEC2
HGNCiHGNC:605 APOBEC2
HPAiHPA014252
HPA017957
MIMi604797 gene
neXtProtiNX_Q9Y235
OpenTargetsiENSG00000124701
PharmGKBiPA24890
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IX13 Eukaryota
ENOG4111K4B LUCA
GeneTreeiENSGT00530000062933
HOGENOMiHOG000033754
HOVERGENiHBG107155
KOiK18772
OMAiDEHAGAH
OrthoDBiEOG091G0JNJ
PhylomeDBiQ9Y235
TreeFamiTF331356

Enzyme and pathway databases

ReactomeiR-HSA-72200 mRNA Editing: C to U Conversion
R-HSA-75094 Formation of the Editosome

Miscellaneous databases

EvolutionaryTraceiQ9Y235
GeneWikiiAPOBEC2
GenomeRNAii10930
PROiPR:Q9Y235
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000124701 Expressed in 134 organ(s), highest expression level in skeletal muscle tissue of rectus abdominis
CleanExiHS_APOBEC2
GenevisibleiQ9Y235 HS

Family and domain databases

InterProiView protein in InterPro
IPR013158 APOBEC_N
IPR002125 CMP_dCMP_dom
IPR016193 Cytidine_deaminase-like
PfamiView protein in Pfam
PF08210 APOBEC_N, 1 hit
SUPFAMiSSF53927 SSF53927, 1 hit
PROSITEiView protein in PROSITE
PS51747 CYT_DCMP_DEAMINASES_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiABEC2_HUMAN
AccessioniPrimary (citable) accession number: Q9Y235
Secondary accession number(s): B2R899
, Q53F28, Q5TGU5, Q5TGU6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 19, 2002
Last sequence update: November 1, 1999
Last modified: November 7, 2018
This is version 133 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
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Main funding by: National Institutes of Health

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